From d58a23d827dd5e191ae35bdc72d0a3edfc2b3e29 Mon Sep 17 00:00:00 2001 From: Cornelius Roemer Date: Wed, 25 Sep 2024 22:51:58 +0200 Subject: [PATCH] Fix json2 --- data/nextstrain/sars-cov-2/BA.2.86/tree.json | 2 +- data/nextstrain/sars-cov-2/BA.2.86/tree.json.bak | 1 + data/nextstrain/sars-cov-2/BA.2/tree.json | 2 +- data/nextstrain/sars-cov-2/BA.2/tree.json.bak | 1 + data/nextstrain/sars-cov-2/XBB/tree.json | 2 +- data/nextstrain/sars-cov-2/XBB/tree.json.bak | 1 + data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json | 2 +- data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json.bak | 1 + data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json | 2 +- data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json.bak | 1 + 10 files changed, 10 insertions(+), 5 deletions(-) create mode 100644 data/nextstrain/sars-cov-2/BA.2.86/tree.json.bak create mode 100644 data/nextstrain/sars-cov-2/BA.2/tree.json.bak create mode 100644 data/nextstrain/sars-cov-2/XBB/tree.json.bak create mode 100644 data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json.bak create mode 100644 data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json.bak diff --git a/data/nextstrain/sars-cov-2/BA.2.86/tree.json b/data/nextstrain/sars-cov-2/BA.2.86/tree.json index 234a5c45..dba82acc 100644 --- a/data/nextstrain/sars-cov-2/BA.2.86/tree.json +++ b/data/nextstrain/sars-cov-2/BA.2.86/tree.json @@ -1 +1 @@ -{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{"nuc":["T21C","A897C","T3431G","G7842A","T8293C","A8393G","T11042G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12789C","C13339T","A15756T","G18492A","T21622C","C21624G","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21711C","T21941G","C22032T","A22033C","G22034A","T22208C","A22295C","A22353C","G22556A","C22577G","C22629A","A22770G","C22895G","A22896T","A22898G","G22910A","T22916C","G22917T","A22942T","A23005T","A23012G","A23013C","C23018T","C23019T","A23040G","A23222G","T23271C","T23423C","G23604A","T24378C","T24990C","T25207C","C26529G","G26610A","T26681C","T26833C","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28958C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["H3D","A30T","V104A"],"N":["E31-","R32-","S33-","K229Q"],"ORF1a":["D211A","L1056V","S2526N","T2710A","F3593V","S3675-","G3676-","F3677-","I4175T"],"ORF9b":["E27-","N28-","A29-"],"S":["T21R","L24-","P25-","P26-","A27S","L50S","F127V","S157F","G158R","F216L","N245H","D264A","V332I","H339D","T356K","K403R","H445V","S446G","D450N","W452L","K460N","K481N","K484A","P486F","Q493R","K554E","V570A","S621P","R681H","F939S","L1143P"]},"labels":{"aa":"M: H3D, A30T, V104A; N: E31-, R32-, S33-, K229Q; ORF1a: D211A, L1056V, S2526N, T2710A, F3593V, S3675-, G3676-, F3677-, I4175T; ORF9b: E27-, N28-, A29-; S: T21R, L24-, P25-, P26-, A27S, L50S, F127V, S157F, G158R, F216L, N245H, D264A, V332I, H339D, T356K, K403R, H445V, S446G, D450N, W452L, K460N, K481N, K484A, P486F, Q493R, K554E, V570A, S621P, R681H, F939S, L1143P","clade":"Omicron","spike_mutations":"T21R, L24-, P25-, P26-, A27S, L50S, F127V, S157F, G158R, F216L, N245H, D264A, V332I, H339D, T356K, K403R, H445V, S446G, D450N, W452L, K460N, K481N, K484A, P486F, Q493R, K554E, V570A, S621P, R681H, F939S, L1143P"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-5.175650596618652}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAA","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAA"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAC","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAC"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAF"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAB","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAB"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAE","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAE"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAD","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAD"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.87846565246582}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAG","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAG"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAJ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAJ"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.570775508880615}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAL","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAL"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAH","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAH"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.748638153076172}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAK","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAK"},"ace2_binding":{"value":"1.15166"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.3037714005953052"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAM","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAM"},"ace2_binding":{"value":"0.75567"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAN","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAN"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.081246852874756}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAR","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAR"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.453131198883057}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAQ","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAQ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAP","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAP"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.001843452453613}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAS","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAS"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.453028202056885}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAT","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"XAT"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.875851631164551}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAV","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAV"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.725754261016846}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":83,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XAW"},"ace2_binding":{"value":"0.91409"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.274687314409391"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E154-","S155-","F157S","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E154-, S155-, F157S, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E154-, S155-, F157S, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAU","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAU"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.1733574867248535}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAZ","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"XAZ"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBA"},"ace2_binding":{"value":"0.20215999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":4},"immune_escape":{"value":"0.29808642936638835"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E154-","S155-","F157S","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBD"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XBE"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.568921089172363}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBG","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"XBG"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBH"},"ace2_binding":{"value":"0.37244999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBM","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"XBM"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBN","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBN"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBP","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBP"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBQ"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBT"},"ace2_binding":{"value":"0.64255"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5037920175803539"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBS"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBR"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBV"},"ace2_binding":{"value":"0.32919999999999994"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBU","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBU"},"ace2_binding":{"value":"0.74825"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBW"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBY","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBY"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"XCB"},"ace2_binding":{"value":"1.41968"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XCA"},"ace2_binding":{"value":"0.74825"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XBZ","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBZ"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCC","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XCC"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCE"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XCD"},"ace2_binding":{"value":"0.95377"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XCG"},"ace2_binding":{"value":"1.16254"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCJ"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCK","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCK"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCM","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCM"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"XCN"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCL","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XCL"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCP","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCP"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCR","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XCR"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCQ","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCQ"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCS","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XCS"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCU","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCU"},"ace2_binding":{"value":"0.8835"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E154-","S155-","F157S","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCV"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCW","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XCW"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCZ","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"XCZ"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XCY","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XCY"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XDB","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XDB"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XDC","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XDC"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XDE"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XDF"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDJ","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XDJ"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XDH"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XDG"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDN","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XDN"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDL","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XDL"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDM","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"XDM"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDS","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDS"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"XDT"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDU","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XDU"},"ace2_binding":{"value":"0.63761"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.9475349114594978"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDY","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XDY"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDW"},"ace2_binding":{"value":"1.15919"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XDZ","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDZ"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XE","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":48},"Nextclade_pango":{"value":"XE"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.6930429935455322}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEA","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XEA"},"ace2_binding":{"value":"1.41162"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2268340125514634"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEB","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XEB"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XED"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XED"},"qc.overallScore":{"value":17.361},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEE","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XEE"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.013909816741943}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XEG"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEG"},"qc.overallScore":{"value":950.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEF","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"XEF"},"ace2_binding":{"value":"-1.12538"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEF"},"qc.overallScore":{"value":34.028},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7268345560655398"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XG"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":9},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XH","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XH"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XK","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":45},"Nextclade_pango":{"value":"XK"},"ace2_binding":{"value":"-3.62446"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XJ","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XJ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XM","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":46},"Nextclade_pango":{"value":"XM"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-31"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.1486592292785645}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XL","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XL"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XP","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XP"},"ace2_binding":{"value":"0.023200000000000068"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3616394203564539"},"placement_prior":{"value":-3.0015511512756348}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XN","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XN"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.342913627624512}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XR","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XR"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XQ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XQ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.572272300720215}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XV","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XV"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.516026020050049}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XT","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XT"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.084201812744141}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XW","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XW"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XU","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XU"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.814977645874023}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XZ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XZ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.090515613555908}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XY"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBK.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBK"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XCH.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCH"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XCT.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"XCT"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"XDA.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XDA"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"XEC.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC.1"},"qc.overallScore":{"value":29.34},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XEC"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"qc.overallScore":{"value":34.028},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XCF"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDP"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDP.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDP.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDP.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDR"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.1","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDR.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.1"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDR.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.2","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDR.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBL.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"placement_prior":{"value":-5.099145412445068}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"XDQ"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.099145412445068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"placement_prior":{"value":-4.498189449310303}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDQ.2"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"XDQ.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"placement_prior":{"value":-4.299689292907715}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XDQ.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.299689292907715}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDQ.1.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ.2"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBJ.4"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBJ.3"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"internal_63f4","node_attrs":{"div":37,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBJ.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBJ.1.1"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XDD"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDD.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDD.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDD.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDD.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDD.1.1.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.5","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.5"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"XDK.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDK.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDK.4.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}},{"name":"XDK.4","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"XDK.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":61,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.1.1"},"ace2_binding":{"value":"1.0469899999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"NODE_0000033","node_attrs":{"div":62,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDK.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}},{"name":"XDK.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.10"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.3351006507873535}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.4"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.3"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.6"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.5"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.9","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.9"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBF.1.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}},{"name":"XBF.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.7"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBF.7.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.8.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}},{"name":"XBF.8","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.8"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E154-","S155-","F157S","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XAY"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XAY.3"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.390021324157715}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.967257976531982}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XAY.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.967257976531982}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XAY.2.3"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.997220993041992}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XAY.2.1"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XAY.2.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.697917938232422}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":61,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XAY.1"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":63,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1.2"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000046","node_attrs":{"div":64,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1.3"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":65,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GL.3"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XAY.1.1.1"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":66,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"placement_prior":{"value":-5.682618141174316}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.2","node_attrs":{"div":72,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GL.2"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}},{"name":"GL.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GL.1"},"ace2_binding":{"value":"0.6888599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752889267417711"},"placement_prior":{"value":-4.494447231292725}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDV"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDV.1.10"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.10"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1.11"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.4","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDV.1.5"},"ace2_binding":{"value":"0.14808999999999992"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5359962252743784"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1.8"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XDV.1.2.1"},"ace2_binding":{"value":"0.26874999999999993"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2.1"},"qc.overallScore":{"value":6.25},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.8051577060608006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}}]},{"name":"NODE_0000052","node_attrs":{"div":61,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.7"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"XDV.1.7.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7.1"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000053","node_attrs":{"div":60,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.9.1"},"ace2_binding":{"value":"0.20783000000000001"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5422010449483097"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":69,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E154-","S155-","F157S","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"XBC"},"ace2_binding":{"value":"0.6871599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-09-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":69,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":74,"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.2"},"ace2_binding":{"value":"0.6871599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.2.1"},"ace2_binding":{"value":"0.58838"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.44507236664312827"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000057","node_attrs":{"div":71,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":71,"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"XBC.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":72,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.5","node_attrs":{"div":76,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.1.5"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"XBC.1.4","node_attrs":{"div":77,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XBC.1.4"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"NODE_0000059","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.1.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"XBC.1.2.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":79,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.1.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":80,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.1.1"},"ace2_binding":{"value":"0.11213999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.48837241784414276"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.1.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":77,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XBC.1.7.1"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7","node_attrs":{"div":77,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.7"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.2","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.7.2"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.1.3"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":79,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.3.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":80,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"KD.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.1","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"KD.1"},"ace2_binding":{"value":"0.7857899999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.4","node_attrs":{"div":84,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"KD.4"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}},{"name":"KD.3","node_attrs":{"div":82,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"KD.3"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":85,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":85,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.6"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.2"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":88,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.4"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":89,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBC.1.6.5"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":86,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":89,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GT.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":88,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":90,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"JT.1"},"ace2_binding":{"value":"0.47217000000000003"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7550301657183831"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":88,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.6.6"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":87,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":87,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.3"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":90,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":93,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HW.1.1"},"ace2_binding":{"value":"0.63844"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.7420325830319254"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HW.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.2","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HW.1.2"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1.3","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HW.1.3"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBB"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.223729610443115}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.390652656555176}},"branch_attrs":{"mutations":{"nuc":["C14178T","-29759G"]}}},{"name":"XBB.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T14574C","-29759G"]}}},{"name":"XBB.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.9"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"placement_prior":{"value":-4.663937568664551}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.4"},"ace2_binding":{"value":"0.3064099999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"placement_prior":{"value":-4.663937568664551}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.4.1"},"ace2_binding":{"value":"0.26627999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0810114368008295"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"internal_ORF1a_G82D","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.418038845062256}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.6.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.6.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C14178T","C14362T","C22792A","C25539T"]}}},{"name":"NODE_0000077","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.8.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.8.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"placement_prior":{"value":-4.484416961669922}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.484416961669922}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.3.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.830880165100098}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.3.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-4.122152805328369}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.122152805328369}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.12"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.178323268890381}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.636689186096191}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.256889343261719}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.545111656188965}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"internal_619ad3bd","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"placement_prior":{"value":-5.454404830932617}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.11"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.454404830932617}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.11.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000082","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.7.1"},"ace2_binding":{"value":"1.65097"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-4.833042144775391}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.10"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000084","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.6.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.6.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GH.1"},"ace2_binding":{"value":"0.35217"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.6.1"},"ace2_binding":{"value":"0.35217"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":34,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.2.3.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.14"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.20"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.2.3.18"},"ace2_binding":{"value":"0.0750199999999999"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2567103717994188"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.21"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.22"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.5"},"ace2_binding":{"value":"0.84876"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-12"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.456076622009277}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.9"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GZ.1"},"ace2_binding":{"value":"0.92117"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.4"},"ace2_binding":{"value":"0.92117"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JA.1"},"ace2_binding":{"value":"0.13359999999999994"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.13"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JU.1"},"ace2_binding":{"value":"0.84789"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0527558336884004"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.12"},"ace2_binding":{"value":"0.90647"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-4.90196418762207}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.16"},"ace2_binding":{"value":"0.84876"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.17"},"ace2_binding":{"value":"0.89912"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0248043607383275"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JS.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"JS.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JS.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.15"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.19"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JY.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JY.1.1"},"ace2_binding":{"value":"0.88039"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}},{"name":"JY.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JY.1"},"ace2_binding":{"value":"0.88039"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.972652912139893}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.6"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GM.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GM.3.1"},"ace2_binding":{"value":"0.89932"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736186906064397"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.8"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"HG.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HG.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}},{"name":"HG.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HG.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.11"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GS.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.295290470123291}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GS.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000102","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GS.2"},"ace2_binding":{"value":"0.7709600000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0079043361863298"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GS.8"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.607783794403076}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GS.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.7"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GS.7"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GS.7.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GS.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GS.4"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GS.4.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}},{"name":"GS.4.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GS.4.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.6","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HH.5"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.8.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.8","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.8"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000111","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.1.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HH.2.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.10"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GE.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GE.1.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GE.1.4"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GE.1.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-4.00916051864624}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GE.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GE.1.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GE.1.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GE.1.2.2"},"ace2_binding":{"value":"0.70075"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.986824739722089"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":45,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GE.1.2.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":49,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KT.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":50,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"KT.1.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KT.1.2"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GJ.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"placement_prior":{"value":-4.2036452293396}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.6"},"ace2_binding":{"value":"0.13359999999999994"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GJ.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.5"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GJ.5.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GJ.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-02"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GJ.1.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GJ.1.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.8"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.7"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GJ.1.2.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GJ.1.2.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.5"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.4524970054626465}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.1"},"ace2_binding":{"value":"0.89912"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0248043607383275"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JE.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":47,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JE.1.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":48,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JE.1.1.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KH.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_XBB1_out","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.063088417053223}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.063088417053223}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.10"},"ace2_binding":{"value":"1.13558"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.3"},"ace2_binding":{"value":"0.49564"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-5.383153915405273}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-5.09111213684082}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.33"},"ace2_binding":{"value":"1.0545"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.49"},"ace2_binding":{"value":"0.89405"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.542330265045166}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.20"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.48"},"ace2_binding":{"value":"-0.9722600000000003"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-7.0218706130981445}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.1.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.19.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GW.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GW.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GW.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.19.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":41,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GW.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GW.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000141","node_attrs":{"div":46,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GW.5"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.2"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":48,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.3"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GW.5.3.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":48,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.1"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":54,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GW.5.1.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KE.2"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KE.3"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}},{"name":"KE.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"KE.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.1298351287841797}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.21"},"ace2_binding":{"value":"0.86729"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.27"},"ace2_binding":{"value":"0.2602599999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.29"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.36"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.40"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.393089294433594}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"XBB.1.7","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.919648170471191}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"internal_32defdcb","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"placement_prior":{"value":-4.727026462554932}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.13"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.727026462554932}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.13.1"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000147","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XBB.1.12.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}},{"name":"XBB.1.12","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.12"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000148","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.14"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.14.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.15"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.15.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.37.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.37"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"placement_prior":{"value":-4.930384159088135}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.38"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.930384159088135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.38.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.0709428787231445}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"placement_prior":{"value":-5.253978729248047}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.43"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.253978729248047}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.43.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"placement_prior":{"value":-5.3449578285217285}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.44"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3449578285217285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.44.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"placement_prior":{"value":-5.039181232452393}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.45"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.039181232452393}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.45.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000155","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.31"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.31.1"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.31.2"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.4.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-25"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.4","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.34.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.34","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HB.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.34.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.9296627044677734}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.30"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.751845836639404}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.39"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.072850704193115}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"placement_prior":{"value":-5.253643989562988}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.32"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.253643989562988}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.32.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"placement_prior":{"value":-4.567584037780762}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.28"},"ace2_binding":{"value":"1.05231"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"placement_prior":{"value":-4.83050012588501}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FW.2"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.068525314331055}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"FW.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FW.3"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.28.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-4.83050012588501}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"placement_prior":{"value":-5.344550132751465}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FW.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF6:3-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.344550132751465}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FW.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FW.1.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF6:3-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FW.1.1.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.11"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FP.4","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.11.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FP.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":38,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FP.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FP.2.1.1"},"ace2_binding":{"value":"0.7388600000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FP.2.1.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"NODE_0000170","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.9296627044677734}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.35"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.46"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.47"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.47.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.24.1"},"ace2_binding":{"value":"1.05408"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000173","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.24.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"XBB.1.24.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.24.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.18"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"placement_prior":{"value":-4.357847690582275}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.18.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.357847690582275}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FE.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FE.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FE.1.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FE.1.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"internal_8af9e862","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FE.1.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000179","node_attrs":{"div":40,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HE.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HE.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"placement_prior":{"value":-6.729740619659424}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.41.2"},"ace2_binding":{"value":"1.6066099999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1099290580037755"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"XBB.1.41","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41"},"ace2_binding":{"value":"1.65784"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-6.729740619659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41.3"},"ace2_binding":{"value":"1.65784"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"JW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JW.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JW.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JW.1.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-5.805068492889404}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.805068492889404}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-5.6849284172058105}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.6"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":40,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"JC.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JC.5"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JC.5.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.2"},"ace2_binding":{"value":"1.43418"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.3"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.4"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.17"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.17.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"NODE_0000188","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GA.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.17.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GA.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.10"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"GA.10.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.10","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.6.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}},{"name":"GA.6","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.8.1"},"ace2_binding":{"value":"0.96117"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000194","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.2.1.1"},"ace2_binding":{"value":"0.80721"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000195","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.7"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.7.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}},{"name":"GA.7.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.7.1"},"ace2_binding":{"value":"0.90647"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}}]},{"name":"NODE_0000196","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.4"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.4.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.4.3"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":46,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GA.4.1"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"GA.4.1.1"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"GA.4.1.3"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"GA.4.1.2"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-3.7878472805023193}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7878472805023193}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.110"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.110"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.23"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.43"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.45"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.58"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.57"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.87"},"ace2_binding":{"value":"0.93509"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.87"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"placement_prior":{"value":-3.8739588260650635}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GF.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8739588260650635}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":31,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-2.2756154537200928}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.10"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.101"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.101"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.104"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.104"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.082764148712158}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.105"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.105"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.5.108"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.108"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.109"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.109"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.960801124572754}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.645129442214966}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.18"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7350516319274902}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.002415180206299}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.8490023612976074}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.29"},"ace2_binding":{"value":"0.41404999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.31"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8875601291656494}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.282256126403809}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.35"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.062932968139648}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.33"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6394481658935547}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.36"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.254404544830322}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.40"},"ace2_binding":{"value":"0.95377"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.19888973236084}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.51"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.52"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.847869634628296}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.54"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.59"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.106851100921631}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.62"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.189829349517822}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.63"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.750345468521118}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.66"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.64"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.1698079109191895}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.67"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7678160667419434}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.69"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.2668538093566895}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.75"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.79"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65611457824707}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.80"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.80"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.274653434753418}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.85"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.85"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.9143218994140625}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.82"},"ace2_binding":{"value":"0.91194"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.82"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.97"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.97"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.98"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.98"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.99"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.99"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"NODE_0000202","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"placement_prior":{"value":-4.359124660491943}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.174046039581299}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.359124660491943}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EM.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"placement_prior":{"value":-4.762969017028809}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GG.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.809885501861572}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.38"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.762969017028809}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"placement_prior":{"value":-3.9225881099700928}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HJ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9225881099700928}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"placement_prior":{"value":-4.109567165374756}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HM.1"},"ace2_binding":{"value":"0.29094"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1023732112409157"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.30"},"ace2_binding":{"value":"0.41123000000000004"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-4.109567165374756}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HQ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.92"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"placement_prior":{"value":-4.495350360870361}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HY.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.282760143280029}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.100"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.495350360870361}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"placement_prior":{"value":-3.7284648418426514}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JK.1"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-4.850557327270508}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.3"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-3.7284648418426514}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JZ.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.107"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KM.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-31"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.50"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.71"},"ace2_binding":{"value":"0.48403999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"placement_prior":{"value":-4.277385711669922}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GC.2"},"ace2_binding":{"value":"0.9061"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.03073601411565"},"placement_prior":{"value":-4.989252090454102}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GC.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.21"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.277385711669922}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"placement_prior":{"value":-4.297374248504639}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.86"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.297374248504639}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"placement_prior":{"value":-5.091251373291016}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HA.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.850919246673584}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HA.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.93"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":41,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HD.1"},"ace2_binding":{"value":"0.7416800000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HD.1.1"},"ace2_binding":{"value":"0.73864"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"placement_prior":{"value":-4.26259183883667}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.55"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.26259183883667}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HP.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HP.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HP.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.95"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HS.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HS.1.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.999212265014648}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}},{"name":"HS.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HS.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"placement_prior":{"value":-4.020705223083496}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FG.1"},"ace2_binding":{"value":"1.1186099999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FG.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.511922359466553}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"FG.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FG.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.16"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.020705223083496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"placement_prior":{"value":-4.372507572174072}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FZ.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.47"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.372507572174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FZ.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FZ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FZ.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HZ.3"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.68"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HZ.2"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}},{"name":"HZ.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HZ.1"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HC.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.44"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":39,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.4","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HC.4"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}},{"name":"HC.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HC.3"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HC.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"placement_prior":{"value":-3.5768113136291504}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"EK.1"},"ace2_binding":{"value":"0.9873000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0346353162114479"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EK.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.174570083618164}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EK.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.5768113136291504}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EK.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EK.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EK.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26"},"placement_prior":{"value":-4.580837726593018}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.26"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.580837726593018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EU.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EU.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":36,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EU.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EU.1.1"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EU.1.1.2"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EU.1.1.1"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EU.1.1.3"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"placement_prior":{"value":-4.349014759063721}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"GN.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.842705726623535}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GN.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GN.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.73"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.349014759063721}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":36,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GN.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"GN.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GN.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GN.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GN.1.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GN.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"GN.1.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GN.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.102"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"JD.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JD.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JD.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":42,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JD.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JD.1.2.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JD.1.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-4.970314979553223}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JD.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.970314979553223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":42,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":44,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.8"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KK.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KK.2"},"ace2_binding":{"value":"-1.20635"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2868306565498102"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000244","node_attrs":{"div":43,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-3.328376531600952}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.2"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JD.1.1.4"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.5"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JD.1.1.3"},"ace2_binding":{"value":"-1.1261900000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3046787170970133"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.6"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.7"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":41,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.11"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.7","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.70"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-05-22"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":43,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GK.5.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.5.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.8.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.4"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.3.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.3.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.12"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":44,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.2"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.2"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.3"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.4"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.2.1"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.2.1.1"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":44,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.1.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.4"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.7","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.1.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}},{"name":"GK.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.11"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.11.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"GK.1.2.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.1.6.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.8"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"GK.1.8.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000259","node_attrs":{"div":49,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GK.1.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":51,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.10.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":52,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"KN.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"KN.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KN.1.1"},"ace2_binding":{"value":"-1.1446400000000003"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3541583181563797"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-2.4133341312408447}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.106"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.106"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.20"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.677788496017456}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.25"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.187700271606445}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.27"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.515899658203125}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.32"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.674118757247925}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.37"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.098421096801758}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.56"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.201076984405518}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.61"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.265189170837402}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.60"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.624792575836182}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.65"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8305318355560303}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.72"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.74"},"ace2_binding":{"value":"0.9630099999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0169257119491577"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.76"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.102489471435547}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.78"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.449106693267822}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.83"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.83"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.545154094696045}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.84"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.84"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.255393981933594}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.81"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.81"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.62812614440918}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.89"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.89"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.88"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.88"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.298462867736816}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.90"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.90"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.91"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.91"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.191501617431641}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.94"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.94"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.96"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.96"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.111917018890381}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000263","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FH.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.17"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GR.1"},"ace2_binding":{"value":"0.83085"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.42"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GU.1"},"ace2_binding":{"value":"0.83156"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9838451476656441"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.41"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GV.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.13517951965332}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.48"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"KA.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.103"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GB.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GB.1"},"ace2_binding":{"value":"0.9350799999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.46"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.77"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":43,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HR.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HR.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HR.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"placement_prior":{"value":-3.817796230316162}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HT.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HT.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.310756206512451}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.49"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.817796230316162}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.53"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JB.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JB.1"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JB.1.1"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]},{"name":"NODE_0000274","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JB.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JB.2"},"ace2_binding":{"value":"1.5945"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JB.2.1"},"ace2_binding":{"value":"1.5945"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FT.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.39"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FT.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FT.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FT.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.3.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FT.3.1.1"},"ace2_binding":{"value":"0.74638"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0924169334128189"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.3"},"ace2_binding":{"value":"0.89299"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.15"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FD.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FD.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FD.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}},{"name":"FD.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FD.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}}]},{"name":"NODE_0000283","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FD.5.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}},{"name":"FD.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FD.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.837927341461182}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.25"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.560931205749512}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.26"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"placement_prior":{"value":-4.2507476806640625}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.2507476806640625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.22.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HU.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.22.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"HU.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HU.1"},"ace2_binding":{"value":"0.86018"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.950188045949472"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HU.1.1"},"ace2_binding":{"value":"0.67693"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9788766097021935"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.22.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}},{"name":"FY.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"placement_prior":{"value":-5.388861656188965}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.6.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.6.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.8.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.8.1.1"},"ace2_binding":{"value":"0.8926499999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}},{"name":"FY.8.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.8.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.86080265045166}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.3.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.3.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.4"},"ace2_binding":{"value":"0.80106"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.2"},"ace2_binding":{"value":"0.80106"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"NODE_0000297","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"placement_prior":{"value":-5.027553558349609}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.4.1"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-5.027553558349609}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.1.1"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.1.2"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"placement_prior":{"value":-5.234410285949707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FY.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.234410285949707}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FY.5.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.5.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"FY.5.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.5.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.5.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.5.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"placement_prior":{"value":-5.343003273010254}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.343003273010254}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.1.4.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}},{"name":"FY.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.1.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_6436aedc","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FY.1.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"FY.1.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000305","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FY.1.2.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FY.1.2.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":39,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"placement_prior":{"value":-2.9962706565856934}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16.10","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.10"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.11"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.181058883666992}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-2.9962706565856934}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.12"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.213220119476318}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.14"},"ace2_binding":{"value":"0.7388600000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.16"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.17"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.129993438720703}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.18"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.19"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.20"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.21"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.22"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.469313621520996}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XBB.1.16.24"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.23"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.350697994232178}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.25"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XBB.1.16.27"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.26"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.198868751525879}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XBB.1.16.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.220455169677734}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.8"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.9"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.036108016967773}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000307","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KJ.1"},"ace2_binding":{"value":"0.64385"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.32"},"ace2_binding":{"value":"0.64385"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JM.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JM.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.15"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":40,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"placement_prior":{"value":-4.32681131362915}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.29"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.30"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.31"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.13"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000311","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"HF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HF.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HF.1.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.093987464904785}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"HF.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.6"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"placement_prior":{"value":-3.1121838092803955}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JF.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JF.3"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JF.4"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"JF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JF.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{}}},{"name":"internal_398cc75a","node_attrs":{"div":47,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"JF.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JF.1.1.2"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JF.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}},{"name":"JF.1.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"JF.1.1.1"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"placement_prior":{"value":-3.4112071990966797}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.4"},"ace2_binding":{"value":"2.14642"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FU.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.4112071990966797}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FU.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.3"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}},{"name":"FU.3.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.3.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}}]},{"name":"NODE_0000319","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FU.1.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.4","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.4"},"ace2_binding":{"value":"0.8164899999999998"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.5","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GY.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.6"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.7","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.8"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.9"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GY.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GY.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":46,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GY.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"GY.1.1.1"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.938050270080566}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.23"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.138284683227539}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000327","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"placement_prior":{"value":-4.201934337615967}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.201934337615967}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.9.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XBB.1.9.6"},"ace2_binding":{"value":"1.13558"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.9.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000329","node_attrs":{"div":33,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GD.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GD.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-4.331242084503174}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GD.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.9.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":34,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"placement_prior":{"value":-3.3911843299865723}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.064053058624268}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.234268665313721}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.16"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.301856517791748}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.25"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.497269630432129}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.27","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.27"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.29","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.29"},"ace2_binding":{"value":"0.7904599999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6592278480529785}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.28","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.34","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FL.36"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.37"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.926265716552734}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.40"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.2174906730651855}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.9","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"FL.7","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.511373996734619}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.6","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.3911843299865723}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000331","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.19"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.19.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.24"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"FL.24.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.24.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.26"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.26"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.26.1"},"ace2_binding":{"value":"1.0848"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9957660361777405"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.30"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.30"},"ace2_binding":{"value":"0.90046"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.30.1"},"ace2_binding":{"value":"0.90046"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.31"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.31"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FL.31.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.33"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.33"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.33.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.513132572174072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000337","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.32"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.32"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.32.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.35"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.35"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.35.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.911900520324707}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.39"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.39"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.39.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.5.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.17"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.17.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.17"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.17.2"},"ace2_binding":{"value":"0.97144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.18"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.18"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.18.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.18.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.20"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.20.1"},"ace2_binding":{"value":"0.5920999999999998"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.20.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.20","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.20"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000345","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.21"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.21.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}},{"name":"FL.21.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.21.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.21"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.3","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.10.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"FL.10.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.10.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"FL.10.2"},"ace2_binding":{"value":"0.98073"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1216394663867173"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}}]},{"name":"NODE_0000347","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.23"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.23"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.23.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.23.2"},"ace2_binding":{"value":"0.96117"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.23.2.1"},"ace2_binding":{"value":"0.8835"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.3.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.1"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.13.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.13.2.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":35},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.13.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.3.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.13.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FL.13.4.1"},"ace2_binding":{"value":"0.07635999999999983"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"placement_prior":{"value":-4.673274040222168}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.38"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_24b5ee08","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.15.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000358","node_attrs":{"div":41,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.15.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.15.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000359","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FL.15.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":48,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"FL.15.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000361","node_attrs":{"div":49,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KF.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KF.2"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]}]},{"name":"internal_7f0cfce5","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"placement_prior":{"value":-3.8401038646698}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8401038646698}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6712799072265625}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.2.3.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.2.7.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000366","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.4.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.8"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.455664157867432}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-3.775200128555298}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.4.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.4"},"ace2_binding":{"value":"0.93509"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.7"},"ace2_binding":{"value":"0.97144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.4.1"},"ace2_binding":{"value":"0.48144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0186868047371063"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.1.1"},"ace2_binding":{"value":"0.3348299999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000369","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FL.1.8"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.6"},"ace2_binding":{"value":"0.89211"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9778643306477401"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"placement_prior":{"value":-4.54828405380249}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.54828405380249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000374","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.5.2"},"ace2_binding":{"value":"0.06800999999999986"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000375","node_attrs":{"div":47,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"KC.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"KC.1.1"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"KC.1"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000376","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.5.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.5"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.6"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000377","node_attrs":{"div":46,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HN.4"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.4.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000378","node_attrs":{"div":47,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.4.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"HN.4.1.1"},"ace2_binding":{"value":"0.0007299999999998658"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005141566416802"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000379","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"placement_prior":{"value":-3.123271942138672}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.8","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.8"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"HN.7","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HN.7"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.777099132537842}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"NODE_0000380","node_attrs":{"div":45,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HN.2.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000381","node_attrs":{"div":44,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.3"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.3.1"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000382","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"placement_prior":{"value":-3.6187987327575684}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.13","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.14","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.12","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.7","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.7"},"ace2_binding":{"value":"1.1186099999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6187987327575684}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.9"},"ace2_binding":{"value":"1.20938"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.9.1"},"ace2_binding":{"value":"1.17686"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.10"},"ace2_binding":{"value":"1.17686"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.10.1"},"ace2_binding":{"value":"1.1256300000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"EG.10.1.1"},"ace2_binding":{"value":"1.1256300000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"placement_prior":{"value":-4.0006818771362305}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.6"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000387","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.6.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.6.1.1"},"ace2_binding":{"value":"0.07635999999999983"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.6.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000388","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"placement_prior":{"value":-4.091076374053955}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.091076374053955}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.2.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.2.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.2.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.2.4"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}},{"name":"EG.2.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.2.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.4.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EG.4.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000391","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.5","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.1.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"EG.1.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"placement_prior":{"value":-4.937782287597656}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"internal_cc5f07eb","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.2.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.2.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000395","node_attrs":{"div":46,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"EG.5.2.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EG.5.2.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000396","node_attrs":{"div":42,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"placement_prior":{"value":-3.371582269668579}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.371582269668579}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.10"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.843295574188232}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.12"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.14"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.343207836151123}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.13"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.16"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.17"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.615509510040283}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.19"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.18"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EG.5.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.7"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.310630798339844}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.9"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.4040846824646}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JJ.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.377831935882568}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.11"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JR.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JR.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000400","node_attrs":{"div":49,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JR.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"JR.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JR.1.1.1"},"ace2_binding":{"value":"-0.73257"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-29"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4312755323086508"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000401","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"placement_prior":{"value":-4.454830646514893}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.454830646514893}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000402","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.4"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KB.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"NODE_0000403","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"placement_prior":{"value":-3.3506245613098145}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.3506245613098145}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JG.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JG.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JG.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000404","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JG.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JG.3.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"JG.3.2"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"placement_prior":{"value":-3.8458521366119385}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.4","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3.4"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.12369441986084}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"JG.3.3","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}}]}]},{"name":"NODE_0000405","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"placement_prior":{"value":-3.7382917404174805}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.6"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7382917404174805}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000406","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"placement_prior":{"value":-3.067814826965332}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.1"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-3.067814826965332}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.11"},"ace2_binding":{"value":"0.0887599999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3341105633249508"},"placement_prior":{"value":-5.31048583984375}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.10","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.1.10"},"ace2_binding":{"value":"-0.025979999999999802"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.3","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.3"},"ace2_binding":{"value":"0.21974"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005451981781486"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.5"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.4","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.4"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.8","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.8"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.9"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.7","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.7"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.1"},"ace2_binding":{"value":"0.048559999999999943"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.2"},"ace2_binding":{"value":"-0.38161000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3552393372267753"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000408","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.6"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":52,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"HV.1.6.1"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000410","node_attrs":{"div":53,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"KL.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"KL.1.1"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"KL.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"KL.1"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000411","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.12"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.19","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.19"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.508697986602783}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.18","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.18"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.17","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.17"},"ace2_binding":{"value":"0.13706999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1972306507819483"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.21","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.21"},"ace2_binding":{"value":"0.1481699999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.205901853206978"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HK.22"},"ace2_binding":{"value":"-0.49366"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.310148541751831"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"HK.25"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-27"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HK.28"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.29"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.32","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.32"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.30","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HK.30"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.31","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.31"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.7"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HK.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}},{"name":"HK.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.11"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}},{"name":"HK.11.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.11.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.20"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.20"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.20.1"},"ace2_binding":{"value":"-0.6088199999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2183176254438959"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.24"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.24"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.24.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.23"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.23"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000418","node_attrs":{"div":51,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.23.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"HK.23.1.1"},"ace2_binding":{"value":"-0.48614000000000007"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3534097328298118"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.27"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.27"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000420","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.27.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HK.27.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.27.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.6"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.26"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.26.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.919094562530518}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"HK.26","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.26"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.33"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.34"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.34"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.34.1"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.13"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.13.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.202107906341553}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.13"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000426","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.13.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"HK.13.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.15","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.14","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.14"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.16"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.089319229125977}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.9"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.8.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"clade_nextstrain":{"value":"23H"},"Nextclade_pango":{"value":"HK.3"},"clade_display":{"value":"23H (HK.3)"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.12"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.13"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.741406440734863}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.11","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.11"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.10","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.14","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.14"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.4","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.4"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.3","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.5","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.7","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"HK.3.9","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"clade_nextstrain":{"value":"23H"},"Nextclade_pango":{"value":"HK.3.2"},"clade_display":{"value":"23H (HK.3)"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"HK.3.2.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"HK.3.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.15","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.15"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.830561637878418}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.16","node_attrs":{"div":1,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.16"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.231330394744873}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.19","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.19"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.5045647621154785}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"placement_prior":{"value":-4.282581329345703}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":1,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2.87"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.282581329345703}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"BA.2.87.1"},"ace2_binding":{"value":"0.8217399999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":41},"immune_escape":{"value":"0.6657453429914796"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-4.726780414581299}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":44},"Nextclade_pango":{"value":"BA.3"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-12-14"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-3.8444693088531494}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":46},"Nextclade_pango":{"value":"BA.1"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"placement_prior":{"value":-0.807468593120575}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"placement_prior":{"value":-2.9267306327819824}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":18},"Nextclade_pango":{"value":"B.1.1.7"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"placement_prior":{"value":-1.1350728273391724}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000436","node_attrs":{"div":63,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"placement_prior":{"value":-1.8536394834518433}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":4},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-1.8536394834518433}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000437","node_attrs":{"div":66,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"placement_prior":{"value":-1.5038626194000244}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":2},"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-1.5038626194000244}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":84,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":19},"Nextclade_pango":{"value":"B.1.617.2"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-04-21"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.617.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":2},"placement_prior":{"value":-0.5609392523765564}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E154-","S155-","F157S","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E154-, S155-, F157S, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E154-, S155-, F157S, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"placement_prior":{"value":-3.074878454208374}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"A","node_attrs":{"div":73,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":1},"Nextclade_pango":{"value":"A"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"A"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-2.9458060264587402}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}},{"name":"B","node_attrs":{"div":70,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":0},"Nextclade_pango":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-3.074878454208374}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000439","node_attrs":{"div":1,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.4854967594146729}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.957334518432617}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.11"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.9937210083007812}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.18"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.061908483505249}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.20"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.934056282043457}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.24"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.01261797446067892"},"placement_prior":{"value":-3.048593759536743}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.26"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.5785772800445557}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.27","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.27"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9512088298797607}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.28","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.28"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.956737041473389}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.29"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.246607542037964}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.30","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.30"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.18751859664917}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.32"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.726752996444702}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.4","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.4"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7649905681610107}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.39","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.39"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.42","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.42"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.43"},"ace2_binding":{"value":"0.11284999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"placement_prior":{"value":-4.410691261291504}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.41","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.41"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.730849266052246}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.46"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.784368991851807}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.5","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.5907044410705566}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.48","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.48"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7901194095611572}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.50"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.213822364807129}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.55"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.216464996337891}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.54","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.54"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.137808799743652}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.59","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.59"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.600815773010254}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.58","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.58"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.060970783233643}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.60","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.60"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.61","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.61"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.497117042541504}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.62"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.002424240112305}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.65","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.65"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.866245985031128}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.63","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.63"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.172652721405029}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.64","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.64"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.522981643676758}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.70","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.70"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.473325729370117}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.2.77"},"ace2_binding":{"value":"0.9213199999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3221048136122174"},"placement_prior":{"value":-5.583920955657959}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.8"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3261396884918213}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.82","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.82"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.82"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-5.217201232910156}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BA.2.83"},"ace2_binding":{"value":"1.12534"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.83"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.22071783986880583"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.85"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.85"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.306359767913818}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000440","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"placement_prior":{"value":-3.565204381942749}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.565204381942749}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.2.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000441","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"placement_prior":{"value":-3.137417793273926}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2.23"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.137417793273926}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.23.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"placement_prior":{"value":-3.8251442909240723}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.31"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8251442909240723}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.31.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.869025230407715}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000443","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.8954713344573975}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.33"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.087352752685547}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}},{"name":"BA.2.35","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.35"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-29"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.5710673332214355}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"placement_prior":{"value":-3.801487684249878}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.40"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.801487684249878}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.40.1"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.7480976581573486}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000445","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"placement_prior":{"value":-2.980782985687256}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.56.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.698922157287598}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}},{"name":"BA.2.56","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.56"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-2.980782985687256}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000446","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"placement_prior":{"value":-2.63692569732666}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.10"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.63692569732666}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.685930013656616}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.080471038818359}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.2.10.4"},"ace2_binding":{"value":"0.73328"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3166622371297313"},"placement_prior":{"value":-5.095425605773926}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"placement_prior":{"value":-3.47294282913208}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.47294282913208}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BJ.1"},"ace2_binding":{"value":"0.09519000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.6181860283242497"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000448","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.908718228340149}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.14"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.6936566829681396}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.22"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.2798104286193848}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.34"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.117501735687256}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.36"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.086648941040039}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.47","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.47"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.130222797393799}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.49"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8066632747650146}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.52","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.52"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8890018463134766}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.51","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.51"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.761199712753296}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.6","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.6"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.67008113861084}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.7","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3845059871673584}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.69","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.69"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.045986652374268}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.71","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.71"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7314822673797607}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.72","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.72"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7303617000579834}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.80"},"ace2_binding":{"value":"0.10838000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.80"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.31190394480802347"},"placement_prior":{"value":-5.6476006507873535}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.81"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.81"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.353763580322266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.25"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.25.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.996367931365967}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"NODE_0000450","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.908718228340149}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.45","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.45"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"placement_prior":{"value":-3.7347371578216553}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.53","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.53"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.7460625171661377}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.44"},"ace2_binding":{"value":"0.11284999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"placement_prior":{"value":-4.219630718231201}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"placement_prior":{"value":-3.5669286251068115}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13.1","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.13.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.0240631103515625}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}},{"name":"BA.2.13","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.13"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.5669286251068115}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000453","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"placement_prior":{"value":-2.193769931793213}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9.1","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.9.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.9"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.193769931793213}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.628756284713745}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.9.4"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.2406187057495117}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.9.6"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.5066680908203125}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.9.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3531694412231445}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}}]}]},{"name":"NODE_0000454","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"placement_prior":{"value":-2.485149383544922}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.1285207271575928}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.10","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.10"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.099079132080078}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.485149383544922}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.12"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.11"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7979795932769775}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.13"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.348191738128662}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.14"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.958454132080078}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.15"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8729355335235596}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.18"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.462960243225098}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.17"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8992807865142822}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.19"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-4.70241117477417}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.302166938781738}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.4"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.3.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.8"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.9"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8521692752838135}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.16"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BP.1"},"ace2_binding":{"value":"0.9456899999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.43687237373984505"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"placement_prior":{"value":-4.601692199707031}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.3.21"},"ace2_binding":{"value":"1.06758"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.830438613891602}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DD.1"},"ace2_binding":{"value":"0.9683399999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4733677107846063"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000457","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"placement_prior":{"value":-4.1717400550842285}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BA.2.3.22"},"ace2_binding":{"value":"0.37526000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.42289430257523936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.6"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.009570121765137}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"placement_prior":{"value":-3.9328742027282715}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9328742027282715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000459","node_attrs":{"div":29,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BS.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BS.1"},"ace2_binding":{"value":"0.66194"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-12"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.49181526572268314"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"BS.1.1"},"ace2_binding":{"value":"0.6589000000000002"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.6029918987948071"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"BS.1.2"},"ace2_binding":{"value":"0.66821"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.4975483601650658"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"internal_a315","node_attrs":{"div":26,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BA.2.3.20"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CM.10"},"ace2_binding":{"value":"0.8190299999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7593324873420084"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000461","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.4"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.4"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.4.1"},"ace2_binding":{"value":"0.91683"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7016283989012374"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.6"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.6"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.6.1"},"ace2_binding":{"value":"0.9440299999999998"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8143059671640498"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000463","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.5"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.5.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.5.2"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"CM.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CM.5"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.8"},"ace2_binding":{"value":"0.99403"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7255583352017505"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000465","node_attrs":{"div":30,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.8.1"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CM.8.1.2"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CM.8.1.4"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000466","node_attrs":{"div":31,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CM.8.1.5"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"CM.8.1.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.8.1.3"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"NODE_0000467","node_attrs":{"div":35,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.8.1.1"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FV.1"},"ace2_binding":{"value":"0.28625999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0761544902802131"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.12"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.11"},"ace2_binding":{"value":"0.35566999999999993"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0179803928276123"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.3"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.9"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.2"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.2.1"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000470","node_attrs":{"div":29,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.7"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.7"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000471","node_attrs":{"div":30,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.7.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"CM.7.1.1"},"ace2_binding":{"value":"0.9729599999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9785485534494837"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}},{"name":"CM.7.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.7.1"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000472","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.1293535232543945}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.17"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.112788200378418}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.21"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.37"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.1010122299194336}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.57"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.166472434997559}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.66"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.675938129425049}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.68"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9366536140441895}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.73"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.040555000305176}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.74"},"ace2_binding":{"value":"0.21698000000000003"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.33134042675697756"},"placement_prior":{"value":-3.888690233230591}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.78"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.6647868156433105}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000473","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0962488651275635}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.67"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000474","node_attrs":{"div":6,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"placement_prior":{"value":-4.71979284286499}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79.1","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.79.1"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}},{"name":"BA.2.79","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.79"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"placement_prior":{"value":-4.71979284286499}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000475","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"placement_prior":{"value":-3.6624863147735596}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.76"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-3.6624863147735596}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000476","node_attrs":{"div":6,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.76.2"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.76.1"},"ace2_binding":{"value":"0.18492"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.2640232066165751"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}}]}]},{"name":"NODE_0000477","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-3.4443867206573486}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.38"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.4443867206573486}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"placement_prior":{"value":-4.741133213043213}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.38.3"},"ace2_binding":{"value":"0.08445999999999997"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.07383293656037815"},"placement_prior":{"value":-4.741133213043213}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BH.1"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.370455061085298"},"placement_prior":{"value":-4.580904006958008}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"internal_ab43","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-3.989638090133667}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.38.1"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.08612585067749}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-4.910482883453369}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.38.2"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.38.4"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.449790954589844}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"placement_prior":{"value":-3.7970614433288574}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.12"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7970614433288574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.12.2"},"ace2_binding":{"value":"0.07350000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.062348652344665065"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000482","node_attrs":{"div":5,"clade_nextstrain":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"placement_prior":{"value":-3.0566976070404053}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.12.1"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.0566976070404053}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000483","node_attrs":{"div":7,"clade_nextstrain":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"placement_prior":{"value":-1.82924222946167}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BG.2"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-18"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BG.1"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.3","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BG.3"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.567026138305664}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.4","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BG.4"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.5","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BG.5"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-07-28"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.7","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BG.7"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.6","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BG.6"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-08-01"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}}]}]}]},{"name":"NODE_0000484","node_attrs":{"div":18,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"placement_prior":{"value":-3.860531806945801}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BA.2.75"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-3.860531806945801}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.10"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.499698638916016}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BA.2.75.8"},"ace2_binding":{"value":"1.04854"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.7"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-4.541248321533203}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"placement_prior":{"value":-5.736501216888428}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.9"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.736501216888428}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"CB.1"},"ace2_binding":{"value":"0.81858"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.514633655548096}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.4"},"ace2_binding":{"value":"1.13451"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000487","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.2"},"ace2_binding":{"value":"0.7472099999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.2.1"},"ace2_binding":{"value":"0.7472099999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-3.378986358642578}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.3"},"ace2_binding":{"value":"1.24593"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5588825437629772"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000489","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BR.1"},"ace2_binding":{"value":"0.9449499999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.1.1"},"ace2_binding":{"value":"0.9449499999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.1.2"},"ace2_binding":{"value":"0.12575999999999996"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7451886007636047"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000490","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BR.4"},"ace2_binding":{"value":"1.10514"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5013910005227346"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000491","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.5"},"ace2_binding":{"value":"1.03573"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BR.5.1"},"ace2_binding":{"value":"1.03573"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.1"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.4"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000493","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"placement_prior":{"value":-4.207220554351807}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.5"},"ace2_binding":{"value":"1.16854"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000494","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BL.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.2.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000495","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BL.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.1.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.1.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.1.3"},"ace2_binding":{"value":"1.19193"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.1.4"},"ace2_binding":{"value":"1.3464399999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BL.1.5"},"ace2_binding":{"value":"0.56756"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6011952983295785"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.6"},"ace2_binding":{"value":"1.11979"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5544855553668998"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"placement_prior":{"value":-4.681202411651611}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.6"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.681202411651611}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"placement_prior":{"value":-4.277714252471924}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BY.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.277714252471924}},"branch_attrs":{"mutations":{}}},{"name":"internal_147e","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BY.1.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BY.1.2.1"},"ace2_binding":{"value":"0.41646999999999995"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_1967","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"placement_prior":{"value":-5.0982890129089355}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BY.1.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-5.0982890129089355}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BY.1.1.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BA.2.75.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CA.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CA.2"},"ace2_binding":{"value":"0.41646999999999995"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-4.7165374755859375}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.4","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CA.4"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.7"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.5"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CA.6"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CA.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CA.3.1"},"ace2_binding":{"value":"0.2371799999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}},{"name":"CA.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.3"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"placement_prior":{"value":-4.096994876861572}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.5"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.096994876861572}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.4"},"ace2_binding":{"value":"1.14197"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"placement_prior":{"value":-4.784391403198242}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.6"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.629100799560547}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.5"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.532908916473389}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.2"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.2.1"},"ace2_binding":{"value":"1.14197"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.3.1"},"ace2_binding":{"value":"1.08339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.653690335850791"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.3"},"ace2_binding":{"value":"1.11385"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5060716304521155"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000505","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.10"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.11"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.7","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.8"},"ace2_binding":{"value":"0.5340599999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9193315170816834"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"internal_5f66","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.1"},"ace2_binding":{"value":"1.2021600000000001"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.1.1"},"ace2_binding":{"value":"1.2021600000000001"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000507","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000508","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.5.2"},"ace2_binding":{"value":"1.1331"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7470314258752732"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.5.1"},"ace2_binding":{"value":"1.31233"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7815531080803261"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.1.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.4.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.4.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"NODE_0000510","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"BN.1.4.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"BN.1.4.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}},{"name":"BN.1.4.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.4.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}}]}]},{"name":"NODE_0000511","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"placement_prior":{"value":-5.13617467880249}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.9"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.220160961151123}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000512","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.2.1"},"ace2_binding":{"value":"1.21326"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7326886306518271"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.2.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.8"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000513","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FR.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000514","node_attrs":{"div":31,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FR.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FR.1.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FR.1.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FR.1.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000515","node_attrs":{"div":35,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FR.1.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}},{"name":"FR.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FR.1.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-4.497981071472168}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.4"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"DS.1"},"ace2_binding":{"value":"1.16291"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0513083167390975"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"DS.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"DS.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.10"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.12","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.12"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.1.3.2"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.9"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.8"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EJ.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EJ.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.3","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EJ.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-3.269749402999878}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.1.3.11"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.13"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-08-06"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.880107879638672}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000522","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"placement_prior":{"value":-4.307699680328369}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.307699680328369}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.5"},"ace2_binding":{"value":"1.15852"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"placement_prior":{"value":-5.031914710998535}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BM.6"},"ace2_binding":{"value":"1.15852"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"NODE_0000523","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.2.2"},"ace2_binding":{"value":"1.26994"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5272935807019111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.2.1"},"ace2_binding":{"value":"0.81858"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.2.3"},"ace2_binding":{"value":"0.78817"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.1"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.1.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000527","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"BM.1.1.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BM.1.1.5"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.992039680480957}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.1.1.1"},"ace2_binding":{"value":"0.43724"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CJ.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"internal_ed55","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.1"},"ace2_binding":{"value":"0.87567"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9457248359372292"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000531","node_attrs":{"div":28,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CJ.1.3"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.3.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.3.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000532","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000533","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.1.1.3"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CV.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CV.2"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-06"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000534","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BM.1.1.4"},"ace2_binding":{"value":"0.46466000000000013"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000535","node_attrs":{"div":29,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EP.2"},"ace2_binding":{"value":"0.46466000000000013"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000536","node_attrs":{"div":35,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"EP.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EP.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000537","node_attrs":{"div":39,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"EP.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EP.1.1.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}},{"name":"EP.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EP.1.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.4"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.4.1"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.4.1.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CH.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000541","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"placement_prior":{"value":-5.852805137634277}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CH.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CH.3"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"CH.3.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CH.3.1"},"ace2_binding":{"value":"1.0219999999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CH.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CH.1"},"ace2_binding":{"value":"0.36891999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7685109779549473"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000544","node_attrs":{"div":25,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.27"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.7"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000545","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.18"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":29,"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.21"},"ace2_binding":{"value":"0.08511000000000003"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:59-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9441222497200389"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000546","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000547","node_attrs":{"div":31,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"GQ.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GQ.1"},"ace2_binding":{"value":"0.9334899999999999"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GQ.1.1"},"ace2_binding":{"value":"0.9334899999999999"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000548","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-3.513967990875244}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.10"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.15"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.24"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.26"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.25"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.29"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"internal_ddb1","node_attrs":{"div":29,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"DV.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000550","node_attrs":{"div":31,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.8"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"DV.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.3.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"DV.6"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.6.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}},{"name":"DV.6.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.6.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.7"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"DV.7.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000557","node_attrs":{"div":40,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"DV.7.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"DV.7.1.8"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000558","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.6"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"DV.7.1.7"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.2"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"JV.1"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"JV.2"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000561","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.5"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KG.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"KG.2"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000562","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.4"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.3"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.9"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000563","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.28"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.32"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000564","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.13"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.14"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.9"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000565","node_attrs":{"div":27,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.11"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GP.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GP.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GP.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000566","node_attrs":{"div":27,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-3.320462703704834}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.16"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.20"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.23"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.22"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.30"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.8"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.6"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"NODE_0000567","node_attrs":{"div":30,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.12"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FS.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000568","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.19"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FJ.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000569","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.31"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000570","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"JP.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JP.1"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:62-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JP.1.1"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:62-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.17"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000572","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FK.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-31"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.2.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"FK.1.2.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000574","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FK.1.4.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000576","node_attrs":{"div":37,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"FK.1.1.1"},"ace2_binding":{"value":"0.16085999999999998"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9815994835819151"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FK.1.3.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000579","node_attrs":{"div":43,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"placement_prior":{"value":-4.664889812469482}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.3.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.664889812469482}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JL.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000580","node_attrs":{"div":48,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"LV.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LV.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000581","node_attrs":{"div":50,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"placement_prior":{"value":-4.55715799331665}},"branch_attrs":{"mutations":{"nuc":["C21T","T13339C"]}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-08-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.55715799331665}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"BA.2.86.4"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.5"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000582","node_attrs":{"div":52,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86.6"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"LV.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}}]},{"name":"NODE_0000583","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.7"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-13"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000584","node_attrs":{"div":58,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"MP.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"MP.1"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"MP.1.1"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.6738025507980547"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JQ.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000586","node_attrs":{"div":56,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JQ.2"},"ace2_binding":{"value":"1.15919"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-05"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000587","node_attrs":{"div":60,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JQ.2.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-20"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JQ.2.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JQ.2.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000588","node_attrs":{"div":52,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-5.804113388061523}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.4"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.519156455993652}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000589","node_attrs":{"div":53,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-3.827300786972046}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-3.827300786972046}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.12"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.15","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.15"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.14","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.14"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.18","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.18"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.17","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.17"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.16","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.16"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.19","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.19"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.6"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.381936550140381}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.8","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.8"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.9","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.9"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.700376033782959}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.7","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.7"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"NODE_0000590","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.11"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.11"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.11.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000591","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.13"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.13"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.13.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000592","node_attrs":{"div":56,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","C6525T","C29171T"],"N":["H300Y"],"ORF1a":["P892S","T2087I"]},"labels":{"aa":"N: H300Y; ORF1a: P892S, T2087I"}},"children":[{"name":"JN.3.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.3.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.3.2.1"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]},{"name":"NODE_0000593","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.5"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.5.1"},"ace2_binding":{"value":"0.6465599999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}},{"name":"JN.5","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.5"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000594","node_attrs":{"div":55,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.3","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.3.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"JN.3.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.3.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}}]},{"name":"internal_59b29264","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.3","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.4"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000596","node_attrs":{"div":58,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.2.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.2.2.1"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000597","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-4.352321624755859}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.10"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.503751754760742}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000598","node_attrs":{"div":58,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-2.788231134414673}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-09-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-2.788231134414673}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.10"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.4109206199646}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.12"},"ace2_binding":{"value":"0.26806999999999986"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.2179718017578125}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.17"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.394025802612305}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.19"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.904604911804199}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.21","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.21"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.875519275665283}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.22"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.6741983890533447}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.493799686431885}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.31"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.34"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.491109848022461}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.37"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.408229351043701}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.40"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.050711631774902}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.45"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.297847270965576}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.46"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.232522487640381}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.804265260696411}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.52"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.117598056793213}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.61","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.61"},"ace2_binding":{"value":"0.93036"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.496607246855186"},"placement_prior":{"value":-4.409794807434082}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.62","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.62"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.60","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.60"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.342294692993164}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.66","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"JN.1.66"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"placement_prior":{"value":-4.108686923980713}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.2.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.971951484680176}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.108686923980713}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000600","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.33249568939209}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.20","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.20"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.33249568939209}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.250879764556885}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.23"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"placement_prior":{"value":-5.240912914276123}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"JN.1.23.1"},"ace2_binding":{"value":"2.21099"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.23"},"ace2_binding":{"value":"2.21099"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"placement_prior":{"value":-5.240912914276123}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.24"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"placement_prior":{"value":-5.013424396514893}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.24"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.013424396514893}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.24.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.24.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.323510646820068}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.32"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"placement_prior":{"value":-4.1628737449646}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.32"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.1628737449646}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.32.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.261566638946533}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.38"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"placement_prior":{"value":-4.847131252288818}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.38.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.38"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.847131252288818}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.43"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"placement_prior":{"value":-4.390970706939697}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.43"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.390970706939697}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.43.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.44"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"placement_prior":{"value":-4.742091655731201}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.44"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.742091655731201}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.44.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.850801944732666}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.54"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"placement_prior":{"value":-5.474041938781738}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.54"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.474041938781738}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.54.1"},"ace2_binding":{"value":"0.05681999999999991"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.532734695870142"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.56"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"placement_prior":{"value":-4.913116455078125}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.56"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.913116455078125}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.56.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.56.1"},"ace2_binding":{"value":"0.7602899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5395016697354735"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","-23009G","A23012-"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"placement_prior":{"value":-4.234557628631592}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.234557628631592}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.6.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.4928669929504395}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.59"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"placement_prior":{"value":-4.803600311279297}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.59.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"qc.overallScore":{"value":8.507},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}},{"name":"JN.1.59","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.59"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.803600311279297}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000611","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.63"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"placement_prior":{"value":-5.165487766265869}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.63"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.165487766265869}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.63.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.744463920593262}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"placement_prior":{"value":-6.049203395843506}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.25"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.049203395843506}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"placement_prior":{"value":-6.251752853393555}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.25.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.251752853393555}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LM.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"placement_prior":{"value":-4.3950371742248535}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.29"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3950371742248535}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.29.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MJ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.455280065536499}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.41"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.36"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"placement_prior":{"value":-5.332466125488281}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.36.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.063255786895752}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.36","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.36"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.332466125488281}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.47"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"placement_prior":{"value":-5.005919456481934}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.47"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.005919456481934}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.47.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.47.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.993666172027588}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"placement_prior":{"value":-5.404429912567139}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.51"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.404429912567139}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"placement_prior":{"value":-5.081503391265869}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.51.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.081503391265869}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LJ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"placement_prior":{"value":-4.514355659484863}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.55"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.514355659484863}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"placement_prior":{"value":-5.77592134475708}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.55.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.55.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"NODE_0000623","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"placement_prior":{"value":-4.698468208312988}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":59,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.67"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.698468208312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000624","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.67.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MZ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"placement_prior":{"value":-3.8991429805755615}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.39.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.853466033935547}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"JN.1.39","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.39"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.8991429805755615}},"branch_attrs":{"mutations":{}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"placement_prior":{"value":-4.175995826721191}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.39.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.563828945159912}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.39.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"placement_prior":{"value":-3.966954231262207}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.42"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.966954231262207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.42.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.303705215454102}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"placement_prior":{"value":-5.334356784820557}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.42.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.334356784820557}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"MS.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.50.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.50","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.50"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.50.2"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"ME.1"},"ace2_binding":{"value":"0.27215999999999985"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"placement_prior":{"value":-4.891570091247559}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.53"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.891570091247559}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"placement_prior":{"value":-5.835316181182861}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.53.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.835316181182861}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000633","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LN.1.1"},"ace2_binding":{"value":"0.2595099999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}},{"name":"LN.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"LN.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.65"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.65.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MF.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MF.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"placement_prior":{"value":-4.343825817108154}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.30"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.343825817108154}},"branch_attrs":{"mutations":{}}},{"name":"internal_dafb7842","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"placement_prior":{"value":-5.548880577087402}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.30.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.548880577087402}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"KU.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.693577289581299}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KU.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"placement_prior":{"value":-6.125247478485107}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KU.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KU.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.2","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KU.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.956709861755371}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.35"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.48"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000641","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.48.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"internal_137393d6","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"JN.1.48.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.48.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LD.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_566939b0","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"placement_prior":{"value":-4.3079633712768555}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.58"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3079633712768555}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.40906286239624}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"placement_prior":{"value":-5.875661849975586}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.875661849975586}},"branch_attrs":{"mutations":{}}},{"name":"LR.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LR.2"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}},{"name":"LR.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LR.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.469166278839111}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LR.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"NODE_0000646","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"placement_prior":{"value":-4.500974178314209}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.8"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.500974178314209}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.8.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"internal_edd3fce6","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"placement_prior":{"value":-4.438825607299805}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000648","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KY.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"placement_prior":{"value":-4.780362606048584}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.15"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.780362606048584}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"placement_prior":{"value":-5.424458980560303}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.15.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.424458980560303}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"placement_prior":{"value":-5.752961158752441}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LU.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LU.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2.2","node_attrs":{"div":71,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LU.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"LU.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LU.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LU.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LU.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.396687030792236}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":96},"Nextclade_pango":{"value":"LU.2.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000654","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"placement_prior":{"value":-4.625055313110352}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.28"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.625055313110352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000655","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.28.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"KW.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KW.1.2"},"ace2_binding":{"value":"0.9318500000000001"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3745641202332524"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000657","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KW.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000658","node_attrs":{"div":68,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KW.1.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LG.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"placement_prior":{"value":-4.775076866149902}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.49.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.329537868499756}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.49"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.775076866149902}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"placement_prior":{"value":-5.515918254852295}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.49.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MB.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000662","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MB.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000663","node_attrs":{"div":68,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MB.1.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MV.1"},"ace2_binding":{"value":"0.30217999999999995"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"placement_prior":{"value":-4.533131122589111}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.64"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.533131122589111}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"placement_prior":{"value":-5.344335556030273}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.64.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.344335556030273}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MD.2"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MD.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"placement_prior":{"value":-5.915351390838623}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MD.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.915351390838623}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MD.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MD.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"MD.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"MD.3.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MD.3.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.229307174682617}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.26"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.005617618560791}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000669","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.9326608180999756}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.14"},"ace2_binding":{"value":"1.02389"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.27"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.131450176239014}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.13"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.13.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KS.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KS.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KS.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KS.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KS.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.098633766174316}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.57"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.57"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.57.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.1"},"ace2_binding":{"value":"1.08313"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.566636085510254}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.6906843185424805}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.1756510734558105}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.7.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.7.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000676","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.8"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000677","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MQ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}},{"name":"MQ.2","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MQ.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.7.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LK.1"},"ace2_binding":{"value":"1.04395"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LK.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LK.2.1"},"ace2_binding":{"value":"0.95433"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LK.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"placement_prior":{"value":-3.712366819381714}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.712366819381714}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.77679967880249}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.4"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.743769645690918}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.8"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KQ.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000682","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"placement_prior":{"value":-2.8164637088775635}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.036896228790283}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LL.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KV.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KV.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"placement_prior":{"value":-4.782667636871338}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.782667636871338}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.2"},"ace2_binding":{"value":"1.02389"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000686","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LE.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"placement_prior":{"value":-5.76973295211792}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"LE.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LE.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.76973295211792}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LE.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.145851135253906}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"NODE_0000687","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LE.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.1.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LE.1.3.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"placement_prior":{"value":-3.5281527042388916}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.5281527042388916}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.900146961212158}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.1.8"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000689","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LT.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"placement_prior":{"value":-5.643091678619385}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.643091678619385}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LC.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"placement_prior":{"value":-4.972570896148682}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.972570896148682}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"placement_prior":{"value":-5.62172794342041}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KZ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.62172794342041}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KZ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KZ.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000694","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"placement_prior":{"value":-3.322723865509033}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.10","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1.10"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.8855814933776855}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.391621112823486}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.850395679473877}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1.9"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000695","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.5"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KR.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.5"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000696","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KR.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.4"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.4.1"},"ace2_binding":{"value":"0.2408299999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"qc.overallScore":{"value":11.111},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000697","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KR.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.3","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"KR.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"NODE_0000698","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"placement_prior":{"value":-4.0566229820251465}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.9"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.0566229820251465}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.9.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.607508659362793}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"placement_prior":{"value":-5.146241664886475}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.9.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.146241664886475}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"placement_prior":{"value":-3.996425151824951}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LB.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.996425151824951}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.6","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.9","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LB.1.9"},"ace2_binding":{"value":"0.2408299999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"LB.1.8","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"NODE_0000701","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.3","node_attrs":{"div":67,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.4.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-24"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000702","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.662420749664307}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.7.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.7.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.7.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000704","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.3.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.3.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.472050666809082}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.3.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MH.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000706","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"placement_prior":{"value":-3.9273574352264404}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.16"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-3.9273574352264404}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.16.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.347455024719238}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"placement_prior":{"value":-5.415005207061768}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.16.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.415005207061768}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LA.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LA.2"},"ace2_binding":{"value":"0.04741999999999978"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000709","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"placement_prior":{"value":-4.693892955780029}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.16.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.026412010192871}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.16.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MT.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"NODE_0000711","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"placement_prior":{"value":-4.084128379821777}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.16.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.084128379821777}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LF.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"LF.7"},"ace2_binding":{"value":"0.21767999999999987"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"qc.overallScore":{"value":50.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.817229820305529"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LF.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3.1.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000717","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"placement_prior":{"value":-5.651890277862549}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":61,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.9"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.651890277862549}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000718","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"placement_prior":{"value":-5.674976825714111}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":62,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.9.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.674976825714111}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000719","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000720","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.8.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.8.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}},{"name":"LF.8.1.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LF.8.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"placement_prior":{"value":-4.10247802734375}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.18"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.10247802734375}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.8"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"placement_prior":{"value":-4.954190254211426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.954190254211426}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LS.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"placement_prior":{"value":-5.688791275024414}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.688791275024414}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LH.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LH.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"placement_prior":{"value":-4.828893184661865}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.3"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.828893184661865}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MA.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"placement_prior":{"value":-7.243719577789307}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MA.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.795672416687012}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MA.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MA.1.1.1"},"ace2_binding":{"value":"0.3926199999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"qc.overallScore":{"value":11.111},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}},{"name":"MA.1.1","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MA.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"placement_prior":{"value":-5.446084976196289}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.446084976196289}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LQ.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"placement_prior":{"value":-5.52098274230957}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LQ.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LQ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LQ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LQ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"NODE_0000730","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"placement_prior":{"value":-5.107730865478516}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.18.7"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"MN.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"placement_prior":{"value":-5.1725053787231445}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.1725053787231445}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LY.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LY.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"NODE_0000733","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LZ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LZ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LZ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]},{"name":"NODE_0000735","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LZ.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LZ.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}},{"name":"LZ.2.1","node_attrs":{"div":65,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LZ.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.11"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"placement_prior":{"value":-4.8429436683654785}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.11"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.8429436683654785}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.11.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.5"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.6"},"ace2_binding":{"value":"0.04741999999999978"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.00890588760376}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KP.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000739","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.2"},"ace2_binding":{"value":"0.27333999999999997"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7741516492587035"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.4.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.4.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"KP.4.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"internal_7da46150","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"KP.4.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}},{"name":"KP.4.2.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.4.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]}]}]},{"name":"NODE_0000743","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-02-22"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"MG.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"MU.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"LP.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"internal_bfd296bd","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LP.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000749","node_attrs":{"div":67,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.2","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LP.1.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]}]}]}]},{"name":"NODE_0000750","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2.10","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.10"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.11","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.11"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.616637706756592}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.12","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.12"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.14"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.19"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2.24"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.23"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.9"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2.15"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.15.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.20"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.20.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.20.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.096656799316406}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000754","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.1"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7908990401504723"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.3.4"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"NODE_0000755","node_attrs":{"div":67,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":96},"Nextclade_pango":{"value":"MW.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000756","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"placement_prior":{"value":-3.916172504425049}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.13"},"ace2_binding":{"value":"0.21942999999999988"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.16"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.532754898071289}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.17","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.17"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.18","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.18"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.22"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.321987628936768}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000757","node_attrs":{"div":63,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"KP.3.4.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3.2","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.3.2"},"ace2_binding":{"value":"-1.15242"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5554650921238282"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"KP.3.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.3.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"NODE_0000760","node_attrs":{"div":68,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.3.3.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MR.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.3.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.2","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"ML.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"ML.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"ML.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.4867472648620605}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-09"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.350050449371338}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000764","node_attrs":{"div":70,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"LW.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LW.1.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LW.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.2","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LW.1.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000765","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.1.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.7"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.8"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MY.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MM.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MM.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000768","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.1.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MK.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MK.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"MK.3"},"ace2_binding":{"value":"-1.11924"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7206397516519647"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.3.1.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000770","node_attrs":{"div":67,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.10"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.12"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.14"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.02898645401001}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.16","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.16"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.910944700241089}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.15","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.15"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.3","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.6","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.3801984786987305}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.4","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.5","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.7","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.7"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5369762101413171"},"placement_prior":{"value":-6.544749736785889}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.9"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.347929000854492}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000771","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.11"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.11.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000772","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.13"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.13.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.2.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.050478935241699}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}},{"name":"MC.2","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.8.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}},{"name":"MC.8","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.8"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-3.5445594787597656}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000776","node_attrs":{"div":5,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-4.484652996063232}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.4.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.484652996063232}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000777","node_attrs":{"div":6,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000778","node_attrs":{"div":7,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-2.9143002033233643}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.222130537033081}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.3","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.5","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.7"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.027554035186768}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000779","node_attrs":{"div":10,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"placement_prior":{"value":-2.785705327987671}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.1","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-09-05"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9799063205718994}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-2.785705327987671}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.4.6.3"},"ace2_binding":{"value":"0.71883"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.2","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.4.6.2"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9107766151428223}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000780","node_attrs":{"div":11,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DC.1"},"ace2_binding":{"value":"0.66094"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000781","node_attrs":{"div":7,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-05-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7295260429382324}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.1.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"22A"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.8587093353271484}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.9"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000782","node_attrs":{"div":8,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.4.1.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000783","node_attrs":{"div":9,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BA.4.1.11"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000784","node_attrs":{"div":11,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.4.1.10"},"ace2_binding":{"value":"0.67074"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5308081831240151"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CS.1"},"ace2_binding":{"value":"0.5702799999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.7561969850799493"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000785","node_attrs":{"div":12,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-3.195547103881836}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.195547103881836}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.9"},"ace2_binding":{"value":"0.39901000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.2395057678222656}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"NODE_0000786","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-4.000418663024902}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"ORF1a":["M2096L"]},"labels":{"aa":"ORF1a: M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000787","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"placement_prior":{"value":-2.946962833404541}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.946962833404541}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.5.2","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.5.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.243049144744873}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"NODE_0000788","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"placement_prior":{"value":-2.891695499420166}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.5.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-3.5131309032440186}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"placement_prior":{"value":-3.0766263008117676}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0766263008117676}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000790","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"placement_prior":{"value":-3.1130268573760986}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.6.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9632551670074463}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.6.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.4","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.6.4"},"ace2_binding":{"value":"0.5883099999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000791","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.6.2"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BW.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BW.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BW.1.2"},"ace2_binding":{"value":"0.6570799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000793","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BW.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BW.1.1.1"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BW.1.1.2"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BW.1.1"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000794","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-2.2668097019195557}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"]}},"children":[{"name":"BA.5.1","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.5.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.2668097019195557}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.12"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.4273552894592285}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.11","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.14","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.14"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.96599817276001}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.16"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.954094409942627}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.17"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7746376991271973}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2638373374938965}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.24"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3640358448028564}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.28"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.258039951324463}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.150360584259033}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.30"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.9021801948547363}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.34"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.1470396518707275}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.4","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.6","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.541717767715454}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.7","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.88628888130188}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.8","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6331071853637695}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0000795","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BK.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.15"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DL.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000797","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DH.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000798","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.26"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CU.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.303286075592041}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.1.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.38"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000800","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.1.33"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"EQ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_8226","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.35"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"EB.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_bae4","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"placement_prior":{"value":-3.846775770187378}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.23"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.846775770187378}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"placement_prior":{"value":-3.115823268890381}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DE.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"DE.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0000804","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.430187463760376}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.5.1.18"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000805","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"placement_prior":{"value":-4.06973934173584}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.06973934173584}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BT.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BT.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"placement_prior":{"value":-3.8074188232421875}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.25"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8074188232421875}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"placement_prior":{"value":-5.113685607910156}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"DJ.1"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.113685607910156}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000808","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"placement_prior":{"value":-5.255130290985107}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"DJ.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DJ.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000809","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DJ.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DJ.1.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.5218355655670166}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.27"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7831978797912598}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.29"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CL.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0000813","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"placement_prior":{"value":-4.229829788208008}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0000814","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-2.733313798904419}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0832855701446533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.0474534034729}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.32"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.180713653564453}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000815","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-4.133322715759277}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.20"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.535171985626221}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.36","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.36"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.37"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-3.151113748550415}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.793166160583496}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000818","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.5.10.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000819","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DF.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"DF.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DF.1.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0000820","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-3.7016499042510986}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7016499042510986}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000821","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.677614212036133}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.2.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.677614212036133}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BF.12"},"ace2_binding":{"value":"0.5279"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9531965255737305}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.14"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-3.077155351638794}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"ORF1b":["H1087Y"],"S":["N450D"]},"labels":{"aa":"ORF1b: H1087Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.19","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.17","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.17"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.485513687133789}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.18","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.18"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.091020107269287}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.30"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.33"},"ace2_binding":{"value":"0.6034899999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.5511837005615234}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9146251678466797}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.488147020339966}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000822","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.31"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"placement_prior":{"value":-4.266521453857422}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BF.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.266521453857422}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.31.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.39"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"placement_prior":{"value":-4.000523567199707}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.39.1"},"ace2_binding":{"value":"0.33263"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5959379308450252"},"placement_prior":{"value":-5.37965726852417}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.39"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.000523567199707}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.41"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"placement_prior":{"value":-4.131745338439941}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.41.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.41","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.41"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.131745338439941}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000825","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.462851524353027}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.11.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000826","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"placement_prior":{"value":-5.1659932136535645}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.292901039123535}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.11.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0000827","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.7677369117736816}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7894070148468018}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.28"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2664027214050293}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.35","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.35"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T9727C","C12789T","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"],"S":["N450D"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.36","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.36"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.462024211883545}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000828","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"placement_prior":{"value":-3.4317872524261475}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4317872524261475}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000829","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"placement_prior":{"value":-3.138411521911621}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.10.1"},"ace2_binding":{"value":"0.3218"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.563032084337257"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.138411521911621}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000830","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-3.120866537094116}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.15"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.382185459136963}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.20"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.540201187133789}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000831","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-3.864048957824707}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.27"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3812055587768555}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000832","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.4586398601531982}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.13"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.780573606491089}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.16"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.25"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.29"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.740543842315674}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.34"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-4.685749530792236}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.23"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.741713047027588}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"placement_prior":{"value":-4.337294578552246}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.337294578552246}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.3.1"},"ace2_binding":{"value":"0.48889999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.257171630859375}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000835","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-4.661863803863525}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.24"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000836","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-4.16046142578125}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.16046142578125}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000837","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-2.7555088996887207}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.5.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000838","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.266281604766846}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000839","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-2.605588436126709}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000840","node_attrs":{"div":25,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BF.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-08"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}}]}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.6039862632751465}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.42"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.397184133529663}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.26"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.32"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.257172107696533}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.37"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.416947364807129}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.40"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.287396192550659}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.38"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"placement_prior":{"value":-4.238620281219482}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.38.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.38"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.238620281219482}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.38.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}},{"name":"BF.38.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.38.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}}]},{"name":"NODE_0000844","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.10"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.11","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.12"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.15"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.17"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.18"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.20","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.20"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.21","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.21"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.2"},"ace2_binding":{"value":"0.6393200000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.22","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.22"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9261090755462646}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.26","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.26"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.24","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.24"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.23","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.23"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.092196941375732}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.9"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"BF.7.8","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000845","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.16"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.16.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000846","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.19"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.19"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.19.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0000847","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.5.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000848","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.13"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.13"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.13.1"},"ace2_binding":{"value":"0.6759999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.13.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}}]},{"name":"NODE_0000849","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BF.7.4.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000850","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.4.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.3122618198394775}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.4.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0000851","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.27"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000852","node_attrs":{"div":26,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BF.7.14.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.4","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.325514793395996}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0000853","node_attrs":{"div":27,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000854","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-2.6320736408233643}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.23"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.815145969390869}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.182581424713135}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.40"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.9923183917999268}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000855","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-1.9060567617416382}},"branch_attrs":{"mutations":{"nuc":["C16616A","C27012T","C27513T"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.12"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3895606994628906}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.14","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.14"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.13","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.13"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.6929638385772705}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.19","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7767930030822754}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.22","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4965717792510986}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.29","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.29"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.456769943237305}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.28","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.28"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.146134376525879}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.30","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.30"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.523482322692871}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.34","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.34"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.511476755142212}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.35"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.6543288230895996}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.37"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.394333839416504}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.39"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.5.2.42"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.43"},"ace2_binding":{"value":"0.5642800000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5413273873731987"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.44"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.278106212615967}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.46"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.212985038757324}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.45","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.45"},"ace2_binding":{"value":"0.5131699999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.998797416687012}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.54","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.54"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.164445877075195}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.53","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.53"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.224037170410156}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.52","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.52"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.105970859527588}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.55"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9875283241271973}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.59"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.192619323730469}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.5.2.58","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.58"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.236825942993164}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.57"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.694666862487793}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.62"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.162878036499023}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.61","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.61"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.711515426635742}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.63","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.5.2.63"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.8","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9411776065826416}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.285115718841553}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.32"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.365017890930176}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"placement_prior":{"value":-3.7827541828155518}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.27"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7827541828155518}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CF.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.796359539031982}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"NODE_0000858","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.33"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CE.1"},"ace2_binding":{"value":"0.39901000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3798828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"internal_1651","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"placement_prior":{"value":-4.1625542640686035}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.36"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.1625542640686035}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CT.1"},"ace2_binding":{"value":"0.4564899999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7208595659836455"},"placement_prior":{"value":-5.671617031097412}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"placement_prior":{"value":-4.313873291015625}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.38"},"ace2_binding":{"value":"0.56458"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.30660604695253"},"placement_prior":{"value":-4.313873291015625}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DA.1"},"ace2_binding":{"value":"0.6759999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"placement_prior":{"value":-5.4733147621154785}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000861","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.41"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.635266304016113}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.56"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.0257768630981445}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.47"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DQ.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000863","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"placement_prior":{"value":-3.0985805988311768}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.20"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0985805988311768}},"branch_attrs":{"mutations":{}}},{"name":"BV.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BV.2"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.277459144592285}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}},{"name":"BV.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BV.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}}]},{"name":"NODE_0000864","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"placement_prior":{"value":-3.4673714637756348}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4673714637756348}},"branch_attrs":{"mutations":{}}},{"name":"CN.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CN.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}},{"name":"CN.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"CN.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_6217","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BZ.2"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BZ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CD.1"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.5325236320495605}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CD.2"},"ace2_binding":{"value":"0.5594199999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3253063676642168"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0000867","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.49"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DZ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DZ.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]},{"name":"NODE_0000868","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.059089183807373}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.50"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.723017692565918}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.51","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.51"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.60"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000869","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.7"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CY.2"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CY.1"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.678462505340576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0000870","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-3.246659517288208}},"branch_attrs":{"mutations":{"nuc":["T27012C","T27513C"]}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.743002891540527}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6277518272399902}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000871","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"placement_prior":{"value":-3.8559513092041016}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.26"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8559513092041016}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CG.1"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]}]},{"name":"internal_a7d2","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.16"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BU.1"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.204470634460449}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BU.3"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}},{"name":"BU.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BU.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.25"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DB.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.356487274169922}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DB.2"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DB.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"DB.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}}]},{"name":"internal_93c4","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.18"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CR.2"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.905637264251709}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0000876","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"placement_prior":{"value":-4.66331672668457}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CR.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.66331672668457}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000877","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"placement_prior":{"value":-4.36233377456665}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CR.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CR.1.2"},"ace2_binding":{"value":"0.40216999999999997"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CR.1.3"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000878","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.48"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7050411701202393}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000879","node_attrs":{"div":25,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DY.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DY.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}}]},{"name":"NODE_0000880","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"placement_prior":{"value":-3.8912155628204346}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.5254948139190674}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7626357078552246}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"placement_prior":{"value":-3.2016091346740723}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.2016091346740723}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.3"},"ace2_binding":{"value":"0.38661"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-4.828918933868408}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.2"},"ace2_binding":{"value":"0.6942999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.5295255377787571"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.6","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.885843276977539}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.7","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CP.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.4","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.628321170806885}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.973639488220215}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"internal_7ebe","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CP.8"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"CP.8.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}}]},{"name":"NODE_0000883","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CP.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"CP.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.1.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-5.384389877319336}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.1.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.319447994232178}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}},{"name":"CP.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.1.3"},"ace2_binding":{"value":"0.6003199999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"internal_605c","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"placement_prior":{"value":-4.047678470611572}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.24"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.047678470611572}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.240954875946045}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CK.2"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"placement_prior":{"value":-4.374808311462402}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.2.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.374808311462402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000887","node_attrs":{"div":27,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CK.2.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DG.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0000888","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.068136215209961}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CK.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.068136215209961}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0000889","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.982324123382568}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CK.1.2"},"ace2_binding":{"value":"0.71883"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.998134136199951}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CK.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.711119651794434}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0000890","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.607345104217529}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.4"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.5"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0000891","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CK.1.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CK.1.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.657632827758789}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]},{"name":"NODE_0000892","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"placement_prior":{"value":-4.171703815460205}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"ORF1a":["Q556K"]},"labels":{"aa":"ORF1a: Q556K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.171703815460205}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF7a:72-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7826950550079346}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3075408935546875}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000893","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"placement_prior":{"value":-3.80965518951416}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9212589263916016}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.250945091247559}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}}]},{"name":"NODE_0000894","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{}}},{"name":"BE.3","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2200913429260254}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000895","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.430433750152588}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.10"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.9"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.668551206588745}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000896","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.247138023376465}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-","T28693C"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.13"},"ace2_binding":{"value":"0.5231200000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.5088823627149919"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":1},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.8"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":94},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]},{"name":"NODE_0000897","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-3.7212204933166504}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.12","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.12"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.008347988128662}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0000898","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.290442943572998}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T"],"ORF1a":["M85-"]},"labels":{"aa":"ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.6"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.737891674041748}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.395222187042236}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000899","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.679184913635254}},"branch_attrs":{"mutations":{"nuc":["C13342T"]}},"children":[{"name":"BE.2","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8559343814849854}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G"],"ORF1a":["T882I"]},"labels":{"aa":"ORF1a: T882I"}}},{"name":"NODE_0000900","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{"nuc":["C10188A","C27800T"],"ORF1a":["T3308N"]},"labels":{"aa":"ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000901","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"placement_prior":{"value":-4.281903266906738}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.4.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.614480018615723}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000902","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.4.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000903","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.4.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"CQ.2"},"ace2_binding":{"value":"0.40216999999999997"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"placement_prior":{"value":-3.9200549125671387}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000904","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CQ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CQ.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CQ.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000905","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"placement_prior":{"value":-3.0249295234680176}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"ORF1b":["M1156I"]},"labels":{"aa":"ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0249295234680176}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BE.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000906","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"placement_prior":{"value":-4.295778751373291}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.295778751373291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000907","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.1.2.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"DW.1"},"ace2_binding":{"value":"0.49383999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8224959014481948"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000908","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.4.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.1.4.3"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0000909","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"placement_prior":{"value":-4.36769437789917}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.4.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BE.1.4.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000910","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"placement_prior":{"value":-2.7709972858428955}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.7709972858428955}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000911","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CC.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000912","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"placement_prior":{"value":-4.0404744148254395}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.1.1"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.0404744148254395}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BQ.2"},"ace2_binding":{"value":"0.45205000000000006"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5680790723509552"},"placement_prior":{"value":-4.677975654602051}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000913","node_attrs":{"div":21,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-3.3798208236694336}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.3798208236694336}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.12"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.383481740951538}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.14"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4368515014648438}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.17"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.728248596191406}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.19"},"ace2_binding":{"value":"0.6127800000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7257362514460642"},"placement_prior":{"value":-4.9549241065979}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.20"},"ace2_binding":{"value":"0.5446"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8308113969466171"},"placement_prior":{"value":-4.456951141357422}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.21"},"ace2_binding":{"value":"0.6570799999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.24"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.423928260803223}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.31"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.428604602813721}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.32"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.33"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.945977687835693}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.5"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4588372707366943}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.4"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.7"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.903951168060303}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.6"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9833500385284424}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.9"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.657703399658203}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000914","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.11"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.11.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000915","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.13.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}},{"name":"BQ.1.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.13"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000916","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.29","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.29"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}},{"name":"BQ.1.28","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.28"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}}]},{"name":"NODE_0000917","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"placement_prior":{"value":-4.865876197814941}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.15"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.865876197814941}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"placement_prior":{"value":-4.009592056274414}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.15.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.111164569854736}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}},{"name":"BQ.1.15.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.15.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.30"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"placement_prior":{"value":-4.176229953765869}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.25"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.176229953765869}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.25.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8304200172424316}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000921","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"placement_prior":{"value":-5.710468292236328}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.26"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.710468292236328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000922","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.26.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.26.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000923","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.3.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.3.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.10"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"internal_fdc9","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.2"},"ace2_binding":{"value":"0.6353800000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6853534127590314"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EC.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EC.1.1"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"EC.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EC.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.2.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.687568426132202}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"internal_dbfb","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.2.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FB.2"},"ace2_binding":{"value":"0.5174000000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6925976779449897"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}},{"name":"FB.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FB.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}}]},{"name":"NODE_0000930","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JH.1"},"ace2_binding":{"value":"0.66664"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9874397743924017"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000931","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BQ.1.2.2"},"ace2_binding":{"value":"0.60833"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9373817650831857"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JH.2"},"ace2_binding":{"value":"0.6059300000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"frameShifts":{"value":"ORF7a:83-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":31},"immune_escape":{"value":"1.0821590912755812"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-2.758084297180176}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.16","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.16"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.18","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.18"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.5462334156036377}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.23"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4519829750061035}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.22"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.056916236877441}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.27"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-4.634747505187988}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.8"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.8.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.8.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FF.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000935","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-2.3916101455688477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1.11","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.11"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-3.890984058380127}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-2.3916101455688477}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.12"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-4.536876678466797}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.16"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.6093573570251465}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.17"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.1477370262146}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.19"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.224153995513916}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.20"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.21"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.24"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9906511306762695}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.25"},"ace2_binding":{"value":"0.7449699999999998"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9883317000263399"},"placement_prior":{"value":-4.071465015411377}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.26"},"ace2_binding":{"value":"0.5921799999999998"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8728938682420008"},"placement_prior":{"value":-4.841145992279053}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.30"},"ace2_binding":{"value":"0.60833"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9373817650831857"},"placement_prior":{"value":-4.599907875061035}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.31"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8225269317626953}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.34"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-5.100788593292236}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.36"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.200608253479004}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.37"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.312097549438477}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.42"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.227291584014893}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.41"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9046671390533447}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.40"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9314393997192383}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.45"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6982264518737793}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.47"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.249356746673584}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.44"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.04910135269165}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.50"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.385881423950195}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.51"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.995375394821167}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.55"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.858496189117432}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.57"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.359898567199707}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.58"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.377610206604004}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.56"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.5291290283203125}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.60"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.216671943664551}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.6"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.973461389541626}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.63"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.370896339416504}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.64"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.916772365570068}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.68"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.0179009437561035}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.67"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.056059837341309}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.66"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.271934509277344}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.69"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6361539363861084}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.70"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8411049842834473}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.73"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.75"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.051732686328446"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.76"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.239201068878174}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.77"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.6623735427856445}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.9"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.718957901000977}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"placement_prior":{"value":-5.200210094451904}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.14"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.200210094451904}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"CW.1"},"ace2_binding":{"value":"0.70602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-5.546139240264893}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000937","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"placement_prior":{"value":-3.995506525039673}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.15"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.995506525039673}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"DM.1"},"ace2_binding":{"value":"0.65602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"placement_prior":{"value":-4.960502624511719}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"placement_prior":{"value":-4.099379062652588}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-19"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.099379062652588}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DU.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000939","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.9369025230407715}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.23"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.7810332775115967}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.27"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.529773712158203}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000940","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.500676155090332}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.29"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.79"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.35"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"ET.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000942","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"placement_prior":{"value":-4.477259635925293}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.65"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.477259635925293}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"ES.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.6746344566345215}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000943","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"placement_prior":{"value":-3.848482608795166}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.7"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.848482608795166}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DK.1"},"ace2_binding":{"value":"0.74371"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-4.994816303253174}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"placement_prior":{"value":-4.450067520141602}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.72"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.450067520141602}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FC.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.900752067565918}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000945","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.8"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DP.1"},"ace2_binding":{"value":"0.66913"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9105813557217661"},"placement_prior":{"value":-4.242033958435059}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"placement_prior":{"value":-3.8017337322235107}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8017337322235107}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"CZ.1"},"ace2_binding":{"value":"0.6774299999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9883317000263399"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"CZ.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000947","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"placement_prior":{"value":-3.908764600753784}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.10"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.908764600753784}},"branch_attrs":{"mutations":{}}},{"name":"FA.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FA.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"FA.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"FA.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.795900344848633}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000948","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"placement_prior":{"value":-4.109678745269775}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.22"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.109678745269775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000949","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"ER.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"placement_prior":{"value":-4.9500412940979}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"ER.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ER.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.9500412940979}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000950","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"placement_prior":{"value":-3.677809476852417}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.677809476852417}},"branch_attrs":{"mutations":{}}},{"name":"DR.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DR.2"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.493982315063477}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"DR.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"DR.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.548750877380371}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}}]},{"name":"NODE_0000951","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.46"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000952","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EN.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EN.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EN.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000953","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.6486151218414307}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.48"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.381720066070557}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.49"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.766873836517334}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.78"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"placement_prior":{"value":-4.132527828216553}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.52"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.132527828216553}},"branch_attrs":{"mutations":{}}},{"name":"EA.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EA.2"},"ace2_binding":{"value":"0.34834999999999994"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.880706782961692"},"placement_prior":{"value":-4.9180803298950195}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}},{"name":"EA.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EA.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.47806978225708}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"placement_prior":{"value":-4.497543811798096}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.53"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.497543811798096}},"branch_attrs":{"mutations":{}}},{"name":"FM.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FM.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.829411506652832}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}},{"name":"FM.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FM.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"placement_prior":{"value":-3.49872088432312}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.18"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.49872088432312}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"ED.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6314659118652344}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ED.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.1880316734313965}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ED.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.8974103927612305}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000957","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.166533946990967}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.54"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.59"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000958","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"placement_prior":{"value":-4.4338603019714355}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.28"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.4338603019714355}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EH.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"placement_prior":{"value":-4.000490188598633}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.32"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.000490188598633}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DT.1"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DT.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.651244640350342}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DT.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.224050998687744}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"NODE_0000960","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{"nuc":["T7633C","C22314T","A24129G"],"S":["P251L","N856S"]},"labels":{"aa":"S: P251L, N856S","spike_mutations":"P251L, N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.38"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EW.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EW.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EW.3"},"ace2_binding":{"value":"0.65602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.116559982299805}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.62"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.4302690029144287}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.61"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000963","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.43"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EZ.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"placement_prior":{"value":-3.492278814315796}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.4"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.492278814315796}},"branch_attrs":{"mutations":{}}},{"name":"EE.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.131551265716553}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.184211254119873}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.4"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.840254783630371}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"EE.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.185059070587158}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.5"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.522100448608398}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}}]},{"name":"NODE_0000965","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"placement_prior":{"value":-4.684232711791992}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.74"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.684232711791992}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FN.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000966","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-6.281740188598633}},"branch_attrs":{"mutations":{"nuc":["C22314T","T23716C","A28834G"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000967","node_attrs":{"div":30,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BQ.1.1.39"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FQ.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-17"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000968","node_attrs":{"div":31,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.71"},"ace2_binding":{"value":"0.24659999999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EV.1"},"ace2_binding":{"value":"0.24659999999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0000969","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"placement_prior":{"value":-4.140890598297119}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.13"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.140890598297119}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.071533679962158}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000971","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"placement_prior":{"value":-4.138623237609863}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.22083044052124}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"placement_prior":{"value":-4.127103805541992}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.127103805541992}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000973","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.1.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EY.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000974","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.5"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6995480060577393}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000975","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"DN.3.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-7.322900772094727}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0000976","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"placement_prior":{"value":-4.858262538909912}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.858262538909912}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000977","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"DN.1.1.1"},"ace2_binding":{"value":"2.05606"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8990816968865659"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"DN.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.2"},"ace2_binding":{"value":"0.5626099999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8771384492554943"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.4"},"ace2_binding":{"value":"0.6722600000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8744814686582322"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MAHSNGTITVEELKKLLEEWNLVIGFLFLAWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFVRTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNKLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKDSCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTLVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDSLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNITLIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLFLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTIKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITTTQLPPAYTNSFTRGVYYPDKVFRSSVLHLTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVFIKVCEFQFCNDPFLDVYYHKNNKSWMESESGVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLGRDFPQGFSALEPLVDLPIGINITRFQTLLALNRSYLTPGDSSSGWTAGAADYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNVTNLCPFHEVFNATRFASVYAWNRTRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIKGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKHSGNYDYWYRLFRKSKLKPFERDISTEIYQAGNKPCKGVKGPNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTKSNKKFLPFQQFGRDIVDTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVSVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSRRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLFSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQLELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCTAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGATTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACATTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAGCCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACTTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTACTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTATTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAATAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAACGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCACAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCGCTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACTACAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTTAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTTTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTCAGGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGGGCGTGATTTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTAAATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGATTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATGTTACAAACTTGTGCCCTTTTCATGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGACGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAAAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGCATAGTGGTAATTATGATTACTGGTATAGATTGTTTAGGAAGTCTAAACTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAAAGGTGTTAAAGGTCCTAATTGTTACTTTCCTTTACAATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTAAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGTTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCTCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCGTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTTTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACTTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTATATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCACATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTGCATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTTCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGTGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACAAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{"nuc":["T21C","A897C","T3431G","G7842A","T8293C","A8393G","T11042G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12789C","C13339T","A15756T","G18492A","T21622C","C21624G","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21711C","T21941G","C22032T","A22033C","G22034A","T22208C","A22295C","A22353C","G22556A","C22577G","C22629A","A22770G","C22895G","A22896T","A22898G","G22910A","T22916C","G22917T","A22942T","A23005T","A23012G","A23013C","C23018T","C23019T","A23040G","A23222G","T23271C","T23423C","G23604A","T24378C","T24990C","T25207C","C26529G","G26610A","T26681C","T26833C","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28958C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["H3D","A30T","V104A"],"N":["E31-","R32-","S33-","K229Q"],"ORF1a":["D211A","L1056V","S2526N","T2710A","F3593V","S3675-","G3676-","F3677-","I4175T"],"ORF9b":["E27-","N28-","A29-"],"S":["T21R","L24-","P25-","P26-","A27S","L50S","F127V","S157F","G158R","F216L","N245H","D264A","V332I","H339D","T356K","K403R","H445V","S446G","D450N","W452L","K460N","K481N","K484A","P486F","Q493R","K554E","V570A","S621P","R681H","F939S","L1143P"]},"labels":{"aa":"M: H3D, A30T, V104A; N: E31-, R32-, S33-, K229Q; ORF1a: D211A, L1056V, S2526N, T2710A, F3593V, S3675-, G3676-, F3677-, I4175T; ORF9b: E27-, N28-, A29-; S: T21R, L24-, P25-, P26-, A27S, L50S, F127V, S157F, G158R, F216L, N245H, D264A, V332I, H339D, T356K, K403R, H445V, S446G, D450N, W452L, K460N, K481N, K484A, P486F, Q493R, K554E, V570A, S621P, R681H, F939S, L1143P","clade":"Omicron","spike_mutations":"T21R, L24-, P25-, P26-, A27S, L50S, F127V, S157F, G158R, F216L, N245H, D264A, V332I, H339D, T356K, K403R, H445V, S446G, D450N, W452L, K460N, K481N, K484A, P486F, Q493R, K554E, V570A, S621P, R681H, F939S, L1143P"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-5.175650596618652}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAA","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAA"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAC","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAC"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAF"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAB","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAB"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAE","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAE"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAD","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAD"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.87846565246582}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAG","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAG"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAJ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAJ"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.570775508880615}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAL","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAL"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAH","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAH"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.748638153076172}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAK","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAK"},"ace2_binding":{"value":"1.15166"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.3037714005953052"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAM","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAM"},"ace2_binding":{"value":"0.75567"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAN","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAN"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.081246852874756}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAR","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAR"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.453131198883057}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAQ","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAQ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAP","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAP"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.001843452453613}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAS","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAS"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.453028202056885}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAT","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"XAT"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.875851631164551}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAV","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAV"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.725754261016846}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":83,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XAW"},"ace2_binding":{"value":"0.91409"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.274687314409391"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E154-","S155-","F157S","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E154-, S155-, F157S, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E154-, S155-, F157S, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAU","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAU"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.1733574867248535}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAZ","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"XAZ"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBA"},"ace2_binding":{"value":"0.20215999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":4},"immune_escape":{"value":"0.29808642936638835"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E154-","S155-","F157S","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBD"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XBE"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.568921089172363}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBG","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"XBG"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBH"},"ace2_binding":{"value":"0.37244999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBM","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"XBM"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBN","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBN"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBP","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBP"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBQ"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBT"},"ace2_binding":{"value":"0.64255"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5037920175803539"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBS"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBR"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBV"},"ace2_binding":{"value":"0.32919999999999994"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBU","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBU"},"ace2_binding":{"value":"0.74825"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBW"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBY","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBY"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"XCB"},"ace2_binding":{"value":"1.41968"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XCA"},"ace2_binding":{"value":"0.74825"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XBZ","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBZ"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCC","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XCC"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCE"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XCD"},"ace2_binding":{"value":"0.95377"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XCG"},"ace2_binding":{"value":"1.16254"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCJ"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCK","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCK"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCM","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCM"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"XCN"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCL","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XCL"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCP","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCP"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCR","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XCR"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCQ","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCQ"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCS","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XCS"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCU","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCU"},"ace2_binding":{"value":"0.8835"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E154-","S155-","F157S","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCV"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCW","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XCW"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCZ","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"XCZ"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XCY","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XCY"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XDB","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XDB"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XDC","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XDC"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XDE"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XDF"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDJ","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XDJ"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XDH"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XDG"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDN","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XDN"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDL","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XDL"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDM","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"XDM"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDS","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDS"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"XDT"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDU","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XDU"},"ace2_binding":{"value":"0.63761"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.9475349114594978"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDY","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XDY"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDW"},"ace2_binding":{"value":"1.15919"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XDZ","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDZ"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XE","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":48},"Nextclade_pango":{"value":"XE"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.6930429935455322}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEA","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XEA"},"ace2_binding":{"value":"1.41162"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2268340125514634"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEB","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XEB"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XED"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XED"},"qc.overallScore":{"value":17.361},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEE","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XEE"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.013909816741943}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XEG"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEG"},"qc.overallScore":{"value":950.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEF","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"XEF"},"ace2_binding":{"value":"-1.12538"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEF"},"qc.overallScore":{"value":34.028},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7268345560655398"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XG"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":9},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XH","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XH"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XK","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":45},"Nextclade_pango":{"value":"XK"},"ace2_binding":{"value":"-3.62446"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XJ","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XJ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XM","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":46},"Nextclade_pango":{"value":"XM"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-31"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.1486592292785645}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XL","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XL"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XP","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XP"},"ace2_binding":{"value":"0.023200000000000068"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3616394203564539"},"placement_prior":{"value":-3.0015511512756348}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XN","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XN"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.342913627624512}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XR","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XR"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XQ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XQ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.572272300720215}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XV","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XV"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.516026020050049}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XT","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XT"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.084201812744141}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XW","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XW"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XU","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XU"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.814977645874023}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XZ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XZ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.090515613555908}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XY"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBK.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBK"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XCH.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCH"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XCT.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"XCT"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"XDA.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XDA"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"XEC.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC.1"},"qc.overallScore":{"value":29.34},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XEC"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"qc.overallScore":{"value":34.028},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XCF"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDP"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDP.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDP.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDP.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDR"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.1","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDR.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.1"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDR.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.2","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDR.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBL.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"placement_prior":{"value":-5.099145412445068}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"XDQ"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.099145412445068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"placement_prior":{"value":-4.498189449310303}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDQ.2"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"XDQ.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"placement_prior":{"value":-4.299689292907715}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XDQ.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.299689292907715}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDQ.1.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ.2"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBJ.4"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBJ.3"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"internal_63f4","node_attrs":{"div":37,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBJ.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBJ.1.1"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XDD"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDD.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDD.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDD.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDD.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDD.1.1.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.5","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.5"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"XDK.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDK.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDK.4.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}},{"name":"XDK.4","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"XDK.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":61,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.1.1"},"ace2_binding":{"value":"1.0469899999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"NODE_0000033","node_attrs":{"div":62,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDK.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}},{"name":"XDK.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.10"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.3351006507873535}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.4"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.3"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.6"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.5"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.9","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.9"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBF.1.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}},{"name":"XBF.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.7"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBF.7.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.8.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}},{"name":"XBF.8","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.8"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E154-","S155-","F157S","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XAY"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XAY.3"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.390021324157715}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.967257976531982}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XAY.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.967257976531982}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XAY.2.3"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.997220993041992}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XAY.2.1"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XAY.2.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.697917938232422}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":61,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XAY.1"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":63,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1.2"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000046","node_attrs":{"div":64,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1.3"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":65,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GL.3"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XAY.1.1.1"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":66,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"placement_prior":{"value":-5.682618141174316}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.2","node_attrs":{"div":72,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GL.2"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}},{"name":"GL.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GL.1"},"ace2_binding":{"value":"0.6888599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752889267417711"},"placement_prior":{"value":-4.494447231292725}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDV"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDV.1.10"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.10"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1.11"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.4","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDV.1.5"},"ace2_binding":{"value":"0.14808999999999992"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5359962252743784"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1.8"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XDV.1.2.1"},"ace2_binding":{"value":"0.26874999999999993"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2.1"},"qc.overallScore":{"value":6.25},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.8051577060608006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}}]},{"name":"NODE_0000052","node_attrs":{"div":61,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.7"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"XDV.1.7.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7.1"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000053","node_attrs":{"div":60,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.9.1"},"ace2_binding":{"value":"0.20783000000000001"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5422010449483097"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":69,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E154-","S155-","F157S","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"XBC"},"ace2_binding":{"value":"0.6871599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-09-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":69,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":74,"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.2"},"ace2_binding":{"value":"0.6871599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.2.1"},"ace2_binding":{"value":"0.58838"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.44507236664312827"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000057","node_attrs":{"div":71,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":71,"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"XBC.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":72,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.5","node_attrs":{"div":76,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.1.5"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"XBC.1.4","node_attrs":{"div":77,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XBC.1.4"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"NODE_0000059","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.1.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"XBC.1.2.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":79,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.1.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":80,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.1.1"},"ace2_binding":{"value":"0.11213999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.48837241784414276"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.1.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":77,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XBC.1.7.1"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7","node_attrs":{"div":77,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.7"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.2","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.7.2"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.1.3"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":79,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.3.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":80,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"KD.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.1","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"KD.1"},"ace2_binding":{"value":"0.7857899999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.4","node_attrs":{"div":84,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"KD.4"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}},{"name":"KD.3","node_attrs":{"div":82,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"KD.3"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":85,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":85,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.6"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.2"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":88,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.4"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":89,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBC.1.6.5"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":86,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":89,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GT.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":88,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":90,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"JT.1"},"ace2_binding":{"value":"0.47217000000000003"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7550301657183831"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":88,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.6.6"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":87,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":87,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.3"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":90,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":93,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HW.1.1"},"ace2_binding":{"value":"0.63844"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.7420325830319254"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HW.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.2","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HW.1.2"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1.3","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HW.1.3"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBB"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.223729610443115}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.390652656555176}},"branch_attrs":{"mutations":{"nuc":["C14178T","-29759G"]}}},{"name":"XBB.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T14574C","-29759G"]}}},{"name":"XBB.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.9"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"placement_prior":{"value":-4.663937568664551}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.4"},"ace2_binding":{"value":"0.3064099999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"placement_prior":{"value":-4.663937568664551}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.4.1"},"ace2_binding":{"value":"0.26627999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0810114368008295"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"internal_ORF1a_G82D","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.418038845062256}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.6.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.6.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C14178T","C14362T","C22792A","C25539T"]}}},{"name":"NODE_0000077","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.8.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.8.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"placement_prior":{"value":-4.484416961669922}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.484416961669922}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.3.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.830880165100098}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.3.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-4.122152805328369}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.122152805328369}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.12"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.178323268890381}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.636689186096191}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.256889343261719}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.545111656188965}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"internal_619ad3bd","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"placement_prior":{"value":-5.454404830932617}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.11"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.454404830932617}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.11.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000082","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.7.1"},"ace2_binding":{"value":"1.65097"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-4.833042144775391}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.10"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000084","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.6.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.6.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GH.1"},"ace2_binding":{"value":"0.35217"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.6.1"},"ace2_binding":{"value":"0.35217"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":34,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.2.3.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.14"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.20"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.2.3.18"},"ace2_binding":{"value":"0.0750199999999999"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2567103717994188"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.21"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.22"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.5"},"ace2_binding":{"value":"0.84876"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-12"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.456076622009277}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.9"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GZ.1"},"ace2_binding":{"value":"0.92117"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.4"},"ace2_binding":{"value":"0.92117"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JA.1"},"ace2_binding":{"value":"0.13359999999999994"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.13"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JU.1"},"ace2_binding":{"value":"0.84789"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0527558336884004"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.12"},"ace2_binding":{"value":"0.90647"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-4.90196418762207}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.16"},"ace2_binding":{"value":"0.84876"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.17"},"ace2_binding":{"value":"0.89912"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0248043607383275"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JS.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"JS.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JS.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.15"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.19"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JY.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JY.1.1"},"ace2_binding":{"value":"0.88039"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}},{"name":"JY.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JY.1"},"ace2_binding":{"value":"0.88039"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.972652912139893}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.6"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GM.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GM.3.1"},"ace2_binding":{"value":"0.89932"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736186906064397"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.8"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"HG.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HG.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}},{"name":"HG.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HG.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.11"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GS.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.295290470123291}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GS.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000102","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GS.2"},"ace2_binding":{"value":"0.7709600000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0079043361863298"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GS.8"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.607783794403076}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GS.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.7"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GS.7"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GS.7.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GS.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GS.4"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GS.4.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}},{"name":"GS.4.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GS.4.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.6","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HH.5"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.8.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.8","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.8"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000111","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.1.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HH.2.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.10"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GE.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GE.1.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GE.1.4"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GE.1.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-4.00916051864624}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GE.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GE.1.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GE.1.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GE.1.2.2"},"ace2_binding":{"value":"0.70075"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.986824739722089"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":45,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GE.1.2.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":49,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KT.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":50,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"KT.1.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KT.1.2"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GJ.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"placement_prior":{"value":-4.2036452293396}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.6"},"ace2_binding":{"value":"0.13359999999999994"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GJ.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.5"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GJ.5.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GJ.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-02"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GJ.1.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GJ.1.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.8"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.7"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GJ.1.2.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GJ.1.2.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.5"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.4524970054626465}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.1"},"ace2_binding":{"value":"0.89912"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0248043607383275"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JE.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":47,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JE.1.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":48,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JE.1.1.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KH.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_XBB1_out","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.063088417053223}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.063088417053223}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.10"},"ace2_binding":{"value":"1.13558"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.3"},"ace2_binding":{"value":"0.49564"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-5.383153915405273}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-5.09111213684082}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.33"},"ace2_binding":{"value":"1.0545"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.49"},"ace2_binding":{"value":"0.89405"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.542330265045166}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.20"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.48"},"ace2_binding":{"value":"-0.9722600000000003"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-7.0218706130981445}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.1.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.19.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GW.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GW.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GW.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.19.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":41,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GW.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GW.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000141","node_attrs":{"div":46,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GW.5"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.2"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":48,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.3"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GW.5.3.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":48,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.1"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":54,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GW.5.1.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KE.2"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KE.3"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}},{"name":"KE.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"KE.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.1298351287841797}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.21"},"ace2_binding":{"value":"0.86729"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.27"},"ace2_binding":{"value":"0.2602599999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.29"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.36"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.40"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.393089294433594}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"XBB.1.7","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.919648170471191}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"internal_32defdcb","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"placement_prior":{"value":-4.727026462554932}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.13"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.727026462554932}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.13.1"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000147","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XBB.1.12.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}},{"name":"XBB.1.12","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.12"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000148","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.14"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.14.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.15"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.15.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.37.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.37"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"placement_prior":{"value":-4.930384159088135}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.38"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.930384159088135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.38.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.0709428787231445}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"placement_prior":{"value":-5.253978729248047}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.43"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.253978729248047}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.43.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"placement_prior":{"value":-5.3449578285217285}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.44"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3449578285217285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.44.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"placement_prior":{"value":-5.039181232452393}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.45"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.039181232452393}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.45.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000155","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.31"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.31.1"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.31.2"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.4.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-25"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.4","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.34.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.34","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HB.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.34.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.9296627044677734}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.30"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.751845836639404}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.39"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.072850704193115}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"placement_prior":{"value":-5.253643989562988}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.32"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.253643989562988}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.32.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"placement_prior":{"value":-4.567584037780762}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.28"},"ace2_binding":{"value":"1.05231"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"placement_prior":{"value":-4.83050012588501}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FW.2"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.068525314331055}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"FW.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FW.3"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.28.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-4.83050012588501}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"placement_prior":{"value":-5.344550132751465}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FW.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF6:3-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.344550132751465}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FW.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FW.1.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF6:3-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FW.1.1.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.11"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FP.4","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.11.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FP.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":38,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FP.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FP.2.1.1"},"ace2_binding":{"value":"0.7388600000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FP.2.1.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"NODE_0000170","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.9296627044677734}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.35"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.46"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.47"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.47.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.24.1"},"ace2_binding":{"value":"1.05408"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000173","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.24.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"XBB.1.24.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.24.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.18"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"placement_prior":{"value":-4.357847690582275}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.18.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.357847690582275}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FE.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FE.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FE.1.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FE.1.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"internal_8af9e862","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FE.1.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000179","node_attrs":{"div":40,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HE.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HE.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"placement_prior":{"value":-6.729740619659424}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.41.2"},"ace2_binding":{"value":"1.6066099999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1099290580037755"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"XBB.1.41","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41"},"ace2_binding":{"value":"1.65784"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-6.729740619659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41.3"},"ace2_binding":{"value":"1.65784"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"JW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JW.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JW.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JW.1.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-5.805068492889404}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.805068492889404}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-5.6849284172058105}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.6"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":40,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"JC.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JC.5"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JC.5.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.2"},"ace2_binding":{"value":"1.43418"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.3"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.4"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.17"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.17.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"NODE_0000188","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GA.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.17.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GA.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.10"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"GA.10.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.10","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.6.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}},{"name":"GA.6","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.8.1"},"ace2_binding":{"value":"0.96117"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000194","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.2.1.1"},"ace2_binding":{"value":"0.80721"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000195","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.7"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.7.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}},{"name":"GA.7.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.7.1"},"ace2_binding":{"value":"0.90647"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}}]},{"name":"NODE_0000196","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.4"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.4.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.4.3"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":46,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GA.4.1"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"GA.4.1.1"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"GA.4.1.3"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"GA.4.1.2"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-3.7878472805023193}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7878472805023193}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.110"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.110"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.23"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.43"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.45"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.58"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.57"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.87"},"ace2_binding":{"value":"0.93509"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.87"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"placement_prior":{"value":-3.8739588260650635}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GF.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8739588260650635}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":31,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-2.2756154537200928}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.10"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.101"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.101"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.104"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.104"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.082764148712158}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.105"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.105"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.5.108"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.108"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.109"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.109"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.960801124572754}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.645129442214966}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.18"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7350516319274902}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.002415180206299}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.8490023612976074}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.29"},"ace2_binding":{"value":"0.41404999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.31"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8875601291656494}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.282256126403809}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.35"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.062932968139648}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.33"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6394481658935547}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.36"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.254404544830322}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.40"},"ace2_binding":{"value":"0.95377"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.19888973236084}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.51"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.52"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.847869634628296}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.54"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.59"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.106851100921631}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.62"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.189829349517822}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.63"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.750345468521118}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.66"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.64"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.1698079109191895}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.67"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7678160667419434}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.69"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.2668538093566895}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.75"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.79"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65611457824707}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.80"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.80"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.274653434753418}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.85"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.85"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.9143218994140625}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.82"},"ace2_binding":{"value":"0.91194"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.82"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.97"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.97"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.98"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.98"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.99"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.99"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"NODE_0000202","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"placement_prior":{"value":-4.359124660491943}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.174046039581299}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.359124660491943}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EM.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"placement_prior":{"value":-4.762969017028809}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GG.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.809885501861572}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.38"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.762969017028809}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"placement_prior":{"value":-3.9225881099700928}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HJ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9225881099700928}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"placement_prior":{"value":-4.109567165374756}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HM.1"},"ace2_binding":{"value":"0.29094"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1023732112409157"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.30"},"ace2_binding":{"value":"0.41123000000000004"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-4.109567165374756}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HQ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.92"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"placement_prior":{"value":-4.495350360870361}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HY.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.282760143280029}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.100"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.495350360870361}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"placement_prior":{"value":-3.7284648418426514}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JK.1"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-4.850557327270508}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.3"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-3.7284648418426514}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JZ.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.107"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KM.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-31"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.50"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.71"},"ace2_binding":{"value":"0.48403999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"placement_prior":{"value":-4.277385711669922}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GC.2"},"ace2_binding":{"value":"0.9061"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.03073601411565"},"placement_prior":{"value":-4.989252090454102}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GC.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.21"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.277385711669922}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"placement_prior":{"value":-4.297374248504639}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.86"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.297374248504639}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"placement_prior":{"value":-5.091251373291016}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HA.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.850919246673584}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HA.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.93"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":41,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HD.1"},"ace2_binding":{"value":"0.7416800000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HD.1.1"},"ace2_binding":{"value":"0.73864"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"placement_prior":{"value":-4.26259183883667}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.55"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.26259183883667}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HP.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HP.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HP.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.95"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HS.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HS.1.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.999212265014648}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}},{"name":"HS.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HS.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"placement_prior":{"value":-4.020705223083496}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FG.1"},"ace2_binding":{"value":"1.1186099999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FG.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.511922359466553}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"FG.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FG.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.16"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.020705223083496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"placement_prior":{"value":-4.372507572174072}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FZ.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.47"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.372507572174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FZ.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FZ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FZ.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HZ.3"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.68"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HZ.2"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}},{"name":"HZ.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HZ.1"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HC.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.44"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":39,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.4","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HC.4"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}},{"name":"HC.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HC.3"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HC.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"placement_prior":{"value":-3.5768113136291504}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"EK.1"},"ace2_binding":{"value":"0.9873000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0346353162114479"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EK.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.174570083618164}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EK.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.5768113136291504}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EK.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EK.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EK.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26"},"placement_prior":{"value":-4.580837726593018}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.26"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.580837726593018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EU.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EU.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":36,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EU.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EU.1.1"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EU.1.1.2"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EU.1.1.1"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EU.1.1.3"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"placement_prior":{"value":-4.349014759063721}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"GN.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.842705726623535}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GN.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GN.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.73"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.349014759063721}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":36,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GN.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"GN.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GN.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GN.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GN.1.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GN.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"GN.1.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GN.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.102"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"JD.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JD.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JD.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":42,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JD.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JD.1.2.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JD.1.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-4.970314979553223}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JD.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.970314979553223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":42,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":44,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.8"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KK.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KK.2"},"ace2_binding":{"value":"-1.20635"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2868306565498102"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000244","node_attrs":{"div":43,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-3.328376531600952}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.2"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JD.1.1.4"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.5"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JD.1.1.3"},"ace2_binding":{"value":"-1.1261900000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3046787170970133"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.6"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.7"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":41,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.11"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.7","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.70"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-05-22"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":43,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GK.5.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.5.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.8.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.4"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.3.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.3.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.12"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":44,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.2"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.2"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.3"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.4"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.2.1"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.2.1.1"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":44,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.1.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.4"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.7","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.1.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}},{"name":"GK.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.11"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.11.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"GK.1.2.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.1.6.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.8"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"GK.1.8.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000259","node_attrs":{"div":49,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GK.1.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":51,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.10.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":52,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"KN.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"KN.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KN.1.1"},"ace2_binding":{"value":"-1.1446400000000003"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3541583181563797"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-2.4133341312408447}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.106"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.106"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.20"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.677788496017456}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.25"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.187700271606445}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.27"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.515899658203125}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.32"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.674118757247925}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.37"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.098421096801758}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.56"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.201076984405518}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.61"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.265189170837402}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.60"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.624792575836182}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.65"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8305318355560303}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.72"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.74"},"ace2_binding":{"value":"0.9630099999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0169257119491577"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.76"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.102489471435547}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.78"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.449106693267822}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.83"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.83"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.545154094696045}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.84"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.84"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.255393981933594}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.81"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.81"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.62812614440918}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.89"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.89"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.88"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.88"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.298462867736816}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.90"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.90"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.91"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.91"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.191501617431641}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.94"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.94"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.96"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.96"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.111917018890381}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000263","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FH.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.17"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GR.1"},"ace2_binding":{"value":"0.83085"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.42"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GU.1"},"ace2_binding":{"value":"0.83156"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9838451476656441"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.41"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GV.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.13517951965332}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.48"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"KA.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.103"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GB.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GB.1"},"ace2_binding":{"value":"0.9350799999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.46"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.77"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":43,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HR.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HR.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HR.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"placement_prior":{"value":-3.817796230316162}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HT.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HT.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.310756206512451}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.49"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.817796230316162}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.53"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JB.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JB.1"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JB.1.1"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]},{"name":"NODE_0000274","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JB.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JB.2"},"ace2_binding":{"value":"1.5945"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JB.2.1"},"ace2_binding":{"value":"1.5945"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FT.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.39"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FT.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FT.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FT.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.3.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FT.3.1.1"},"ace2_binding":{"value":"0.74638"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0924169334128189"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.3"},"ace2_binding":{"value":"0.89299"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.15"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FD.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FD.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FD.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}},{"name":"FD.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FD.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}}]},{"name":"NODE_0000283","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FD.5.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}},{"name":"FD.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FD.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.837927341461182}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.25"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.560931205749512}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.26"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"placement_prior":{"value":-4.2507476806640625}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.2507476806640625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.22.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HU.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.22.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"HU.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HU.1"},"ace2_binding":{"value":"0.86018"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.950188045949472"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HU.1.1"},"ace2_binding":{"value":"0.67693"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9788766097021935"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.22.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}},{"name":"FY.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"placement_prior":{"value":-5.388861656188965}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.6.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.6.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.8.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.8.1.1"},"ace2_binding":{"value":"0.8926499999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}},{"name":"FY.8.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.8.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.86080265045166}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.3.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.3.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.4"},"ace2_binding":{"value":"0.80106"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.2"},"ace2_binding":{"value":"0.80106"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"NODE_0000297","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"placement_prior":{"value":-5.027553558349609}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.4.1"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-5.027553558349609}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.1.1"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.1.2"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"placement_prior":{"value":-5.234410285949707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FY.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.234410285949707}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FY.5.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.5.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"FY.5.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.5.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.5.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.5.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"placement_prior":{"value":-5.343003273010254}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.343003273010254}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.1.4.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}},{"name":"FY.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.1.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_6436aedc","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FY.1.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"FY.1.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000305","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FY.1.2.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FY.1.2.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":39,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"placement_prior":{"value":-2.9962706565856934}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16.10","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.10"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.11"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.181058883666992}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-2.9962706565856934}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.12"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.213220119476318}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.14"},"ace2_binding":{"value":"0.7388600000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.16"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.17"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.129993438720703}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.18"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.19"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.20"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.21"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.22"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.469313621520996}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XBB.1.16.24"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.23"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.350697994232178}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.25"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XBB.1.16.27"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.26"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.198868751525879}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XBB.1.16.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.220455169677734}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.8"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.9"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.036108016967773}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000307","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KJ.1"},"ace2_binding":{"value":"0.64385"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.32"},"ace2_binding":{"value":"0.64385"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JM.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JM.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.15"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":40,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"placement_prior":{"value":-4.32681131362915}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.29"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.30"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.31"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.13"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000311","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"HF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HF.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HF.1.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.093987464904785}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"HF.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.6"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"placement_prior":{"value":-3.1121838092803955}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JF.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JF.3"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JF.4"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"JF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JF.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{}}},{"name":"internal_398cc75a","node_attrs":{"div":47,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"JF.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JF.1.1.2"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JF.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}},{"name":"JF.1.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"JF.1.1.1"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"placement_prior":{"value":-3.4112071990966797}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.4"},"ace2_binding":{"value":"2.14642"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FU.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.4112071990966797}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FU.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.3"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}},{"name":"FU.3.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.3.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}}]},{"name":"NODE_0000319","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FU.1.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.4","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.4"},"ace2_binding":{"value":"0.8164899999999998"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.5","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GY.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.6"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.7","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.8"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.9"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GY.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GY.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":46,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GY.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"GY.1.1.1"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.938050270080566}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.23"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.138284683227539}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000327","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"placement_prior":{"value":-4.201934337615967}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.201934337615967}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.9.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XBB.1.9.6"},"ace2_binding":{"value":"1.13558"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.9.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000329","node_attrs":{"div":33,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GD.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GD.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-4.331242084503174}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GD.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.9.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":34,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"placement_prior":{"value":-3.3911843299865723}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.064053058624268}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.234268665313721}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.16"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.301856517791748}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.25"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.497269630432129}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.27","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.27"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.29","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.29"},"ace2_binding":{"value":"0.7904599999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6592278480529785}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.28","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.34","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FL.36"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.37"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.926265716552734}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.40"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.2174906730651855}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.9","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"FL.7","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.511373996734619}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.6","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.3911843299865723}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000331","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.19"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.19.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.24"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"FL.24.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.24.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.26"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.26"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.26.1"},"ace2_binding":{"value":"1.0848"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9957660361777405"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.30"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.30"},"ace2_binding":{"value":"0.90046"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.30.1"},"ace2_binding":{"value":"0.90046"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.31"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.31"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FL.31.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.33"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.33"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.33.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.513132572174072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000337","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.32"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.32"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.32.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.35"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.35"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.35.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.911900520324707}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.39"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.39"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.39.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.5.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.17"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.17.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.17"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.17.2"},"ace2_binding":{"value":"0.97144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.18"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.18"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.18.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.18.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.20"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.20.1"},"ace2_binding":{"value":"0.5920999999999998"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.20.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.20","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.20"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000345","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.21"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.21.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}},{"name":"FL.21.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.21.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.21"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.3","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.10.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"FL.10.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.10.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"FL.10.2"},"ace2_binding":{"value":"0.98073"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1216394663867173"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}}]},{"name":"NODE_0000347","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.23"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.23"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.23.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.23.2"},"ace2_binding":{"value":"0.96117"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.23.2.1"},"ace2_binding":{"value":"0.8835"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.3.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.1"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.13.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.13.2.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":35},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.13.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.3.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.13.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FL.13.4.1"},"ace2_binding":{"value":"0.07635999999999983"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"placement_prior":{"value":-4.673274040222168}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.38"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_24b5ee08","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.15.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000358","node_attrs":{"div":41,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.15.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.15.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000359","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FL.15.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":48,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"FL.15.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000361","node_attrs":{"div":49,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KF.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KF.2"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]}]},{"name":"internal_7f0cfce5","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"placement_prior":{"value":-3.8401038646698}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8401038646698}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6712799072265625}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.2.3.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.2.7.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000366","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.4.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.8"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.455664157867432}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-3.775200128555298}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.4.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.4"},"ace2_binding":{"value":"0.93509"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.7"},"ace2_binding":{"value":"0.97144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.4.1"},"ace2_binding":{"value":"0.48144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0186868047371063"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.1.1"},"ace2_binding":{"value":"0.3348299999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000369","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FL.1.8"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.6"},"ace2_binding":{"value":"0.89211"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9778643306477401"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"placement_prior":{"value":-4.54828405380249}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.54828405380249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000374","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.5.2"},"ace2_binding":{"value":"0.06800999999999986"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000375","node_attrs":{"div":47,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"KC.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"KC.1.1"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"KC.1"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000376","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.5.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.5"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.6"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000377","node_attrs":{"div":46,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HN.4"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.4.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000378","node_attrs":{"div":47,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.4.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"HN.4.1.1"},"ace2_binding":{"value":"0.0007299999999998658"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005141566416802"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000379","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"placement_prior":{"value":-3.123271942138672}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.8","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.8"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"HN.7","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HN.7"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.777099132537842}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"NODE_0000380","node_attrs":{"div":45,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HN.2.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000381","node_attrs":{"div":44,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.3"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.3.1"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000382","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"placement_prior":{"value":-3.6187987327575684}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.13","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.14","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.12","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.7","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.7"},"ace2_binding":{"value":"1.1186099999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6187987327575684}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.9"},"ace2_binding":{"value":"1.20938"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.9.1"},"ace2_binding":{"value":"1.17686"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.10"},"ace2_binding":{"value":"1.17686"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.10.1"},"ace2_binding":{"value":"1.1256300000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"EG.10.1.1"},"ace2_binding":{"value":"1.1256300000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"placement_prior":{"value":-4.0006818771362305}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.6"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000387","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.6.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.6.1.1"},"ace2_binding":{"value":"0.07635999999999983"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.6.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000388","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"placement_prior":{"value":-4.091076374053955}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.091076374053955}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.2.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.2.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.2.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.2.4"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}},{"name":"EG.2.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.2.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.4.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EG.4.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000391","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.5","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.1.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"EG.1.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"placement_prior":{"value":-4.937782287597656}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"internal_cc5f07eb","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.2.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.2.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000395","node_attrs":{"div":46,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"EG.5.2.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EG.5.2.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000396","node_attrs":{"div":42,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"placement_prior":{"value":-3.371582269668579}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.371582269668579}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.10"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.843295574188232}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.12"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.14"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.343207836151123}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.13"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.16"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.17"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.615509510040283}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.19"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.18"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EG.5.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.7"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.310630798339844}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.9"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.4040846824646}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JJ.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.377831935882568}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.11"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JR.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JR.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000400","node_attrs":{"div":49,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JR.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"JR.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JR.1.1.1"},"ace2_binding":{"value":"-0.73257"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-29"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4312755323086508"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000401","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"placement_prior":{"value":-4.454830646514893}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.454830646514893}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000402","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.4"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KB.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"NODE_0000403","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"placement_prior":{"value":-3.3506245613098145}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.3506245613098145}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JG.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JG.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JG.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000404","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JG.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JG.3.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"JG.3.2"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"placement_prior":{"value":-3.8458521366119385}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.4","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3.4"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.12369441986084}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"JG.3.3","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}}]}]},{"name":"NODE_0000405","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"placement_prior":{"value":-3.7382917404174805}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.6"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7382917404174805}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000406","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"placement_prior":{"value":-3.067814826965332}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.1"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-3.067814826965332}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.11"},"ace2_binding":{"value":"0.0887599999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3341105633249508"},"placement_prior":{"value":-5.31048583984375}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.10","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.1.10"},"ace2_binding":{"value":"-0.025979999999999802"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.3","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.3"},"ace2_binding":{"value":"0.21974"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005451981781486"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.5"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.4","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.4"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.8","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.8"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.9"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.7","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.7"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.1"},"ace2_binding":{"value":"0.048559999999999943"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.2"},"ace2_binding":{"value":"-0.38161000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3552393372267753"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000408","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.6"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":52,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"HV.1.6.1"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000410","node_attrs":{"div":53,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"KL.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"KL.1.1"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"KL.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"KL.1"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000411","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.12"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.19","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.19"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.508697986602783}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.18","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.18"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.17","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.17"},"ace2_binding":{"value":"0.13706999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1972306507819483"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.21","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.21"},"ace2_binding":{"value":"0.1481699999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.205901853206978"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HK.22"},"ace2_binding":{"value":"-0.49366"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.310148541751831"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"HK.25"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-27"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HK.28"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.29"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.32","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.32"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.30","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HK.30"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.31","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.31"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.7"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HK.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}},{"name":"HK.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.11"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}},{"name":"HK.11.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.11.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.20"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.20"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.20.1"},"ace2_binding":{"value":"-0.6088199999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2183176254438959"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.24"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.24"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.24.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.23"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.23"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000418","node_attrs":{"div":51,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.23.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"HK.23.1.1"},"ace2_binding":{"value":"-0.48614000000000007"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3534097328298118"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.27"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.27"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000420","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.27.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HK.27.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.27.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.6"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.26"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.26.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.919094562530518}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"HK.26","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.26"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.33"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.34"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.34"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.34.1"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.13"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.13.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.202107906341553}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.13"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000426","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.13.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"HK.13.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.15","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.14","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.14"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.16"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.089319229125977}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.9"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.8.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"clade_nextstrain":{"value":"23H"},"Nextclade_pango":{"value":"HK.3"},"clade_display":{"value":"23H (HK.3)"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.12"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.13"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.741406440734863}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.11","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.11"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.10","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.14","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.14"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.4","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.4"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.3","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.5","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.7","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"HK.3.9","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"clade_nextstrain":{"value":"23H"},"Nextclade_pango":{"value":"HK.3.2"},"clade_display":{"value":"23H (HK.3)"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"HK.3.2.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"HK.3.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.15","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.15"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.830561637878418}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.16","node_attrs":{"div":1,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.16"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.231330394744873}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.19","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.19"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.5045647621154785}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"placement_prior":{"value":-4.282581329345703}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":1,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2.87"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.282581329345703}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"BA.2.87.1"},"ace2_binding":{"value":"0.8217399999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":41},"immune_escape":{"value":"0.6657453429914796"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-4.726780414581299}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":44},"Nextclade_pango":{"value":"BA.3"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-12-14"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-3.8444693088531494}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":46},"Nextclade_pango":{"value":"BA.1"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"placement_prior":{"value":-0.807468593120575}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"placement_prior":{"value":-2.9267306327819824}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":18},"Nextclade_pango":{"value":"B.1.1.7"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"placement_prior":{"value":-1.1350728273391724}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000436","node_attrs":{"div":63,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"placement_prior":{"value":-1.8536394834518433}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":4},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-1.8536394834518433}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000437","node_attrs":{"div":66,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"placement_prior":{"value":-1.5038626194000244}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":2},"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-1.5038626194000244}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":84,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":19},"Nextclade_pango":{"value":"B.1.617.2"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-04-21"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.617.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":2},"placement_prior":{"value":-0.5609392523765564}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E154-","S155-","F157S","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E154-, S155-, F157S, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E154-, S155-, F157S, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"placement_prior":{"value":-3.074878454208374}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"A","node_attrs":{"div":73,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":1},"Nextclade_pango":{"value":"A"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"A"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-2.9458060264587402}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}},{"name":"B","node_attrs":{"div":70,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":0},"Nextclade_pango":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-3.074878454208374}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000439","node_attrs":{"div":1,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.4854967594146729}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.957334518432617}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.11"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.9937210083007812}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.18"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.061908483505249}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.20"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.934056282043457}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.24"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.01261797446067892"},"placement_prior":{"value":-3.048593759536743}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.26"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.5785772800445557}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.27","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.27"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9512088298797607}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.28","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.28"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.956737041473389}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.29"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.246607542037964}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.30","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.30"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.18751859664917}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.32"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.726752996444702}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.4","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.4"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7649905681610107}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.39","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.39"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.42","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.42"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.43"},"ace2_binding":{"value":"0.11284999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"placement_prior":{"value":-4.410691261291504}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.41","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.41"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.730849266052246}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.46"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.784368991851807}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.5","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.5907044410705566}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.48","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.48"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7901194095611572}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.50"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.213822364807129}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.55"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.216464996337891}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.54","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.54"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.137808799743652}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.59","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.59"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.600815773010254}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.58","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.58"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.060970783233643}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.60","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.60"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.61","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.61"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.497117042541504}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.62"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.002424240112305}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.65","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.65"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.866245985031128}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.63","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.63"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.172652721405029}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.64","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.64"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.522981643676758}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.70","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.70"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.473325729370117}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.2.77"},"ace2_binding":{"value":"0.9213199999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3221048136122174"},"placement_prior":{"value":-5.583920955657959}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.8"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3261396884918213}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.82","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.82"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.82"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-5.217201232910156}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BA.2.83"},"ace2_binding":{"value":"1.12534"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.83"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.22071783986880583"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.85"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.85"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.306359767913818}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000440","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"placement_prior":{"value":-3.565204381942749}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.565204381942749}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.2.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000441","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"placement_prior":{"value":-3.137417793273926}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2.23"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.137417793273926}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.23.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"placement_prior":{"value":-3.8251442909240723}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.31"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8251442909240723}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.31.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.869025230407715}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000443","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.8954713344573975}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.33"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.087352752685547}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}},{"name":"BA.2.35","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.35"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-29"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.5710673332214355}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"placement_prior":{"value":-3.801487684249878}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.40"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.801487684249878}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.40.1"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.7480976581573486}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000445","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"placement_prior":{"value":-2.980782985687256}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.56.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.698922157287598}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}},{"name":"BA.2.56","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.56"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-2.980782985687256}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000446","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"placement_prior":{"value":-2.63692569732666}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.10"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.63692569732666}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.685930013656616}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.080471038818359}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.2.10.4"},"ace2_binding":{"value":"0.73328"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3166622371297313"},"placement_prior":{"value":-5.095425605773926}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"placement_prior":{"value":-3.47294282913208}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.47294282913208}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BJ.1"},"ace2_binding":{"value":"0.09519000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.6181860283242497"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000448","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.908718228340149}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.14"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.6936566829681396}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.22"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.2798104286193848}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.34"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.117501735687256}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.36"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.086648941040039}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.47","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.47"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.130222797393799}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.49"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8066632747650146}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.52","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.52"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8890018463134766}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.51","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.51"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.761199712753296}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.6","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.6"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.67008113861084}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.7","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3845059871673584}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.69","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.69"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.045986652374268}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.71","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.71"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7314822673797607}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.72","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.72"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7303617000579834}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.80"},"ace2_binding":{"value":"0.10838000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.80"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.31190394480802347"},"placement_prior":{"value":-5.6476006507873535}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.81"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.81"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.353763580322266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.25"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.25.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.996367931365967}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"NODE_0000450","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.908718228340149}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.45","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.45"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"placement_prior":{"value":-3.7347371578216553}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.53","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.53"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.7460625171661377}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.44"},"ace2_binding":{"value":"0.11284999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"placement_prior":{"value":-4.219630718231201}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"placement_prior":{"value":-3.5669286251068115}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13.1","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.13.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.0240631103515625}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}},{"name":"BA.2.13","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.13"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.5669286251068115}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000453","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"placement_prior":{"value":-2.193769931793213}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9.1","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.9.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.9"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.193769931793213}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.628756284713745}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.9.4"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.2406187057495117}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.9.6"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.5066680908203125}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.9.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3531694412231445}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}}]}]},{"name":"NODE_0000454","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"placement_prior":{"value":-2.485149383544922}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.1285207271575928}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.10","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.10"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.099079132080078}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.485149383544922}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.12"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.11"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7979795932769775}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.13"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.348191738128662}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.14"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.958454132080078}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.15"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8729355335235596}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.18"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.462960243225098}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.17"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8992807865142822}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.19"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-4.70241117477417}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.302166938781738}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.4"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.3.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.8"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.9"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8521692752838135}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.16"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BP.1"},"ace2_binding":{"value":"0.9456899999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.43687237373984505"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"placement_prior":{"value":-4.601692199707031}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.3.21"},"ace2_binding":{"value":"1.06758"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.830438613891602}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DD.1"},"ace2_binding":{"value":"0.9683399999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4733677107846063"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000457","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"placement_prior":{"value":-4.1717400550842285}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BA.2.3.22"},"ace2_binding":{"value":"0.37526000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.42289430257523936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.6"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.009570121765137}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"placement_prior":{"value":-3.9328742027282715}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9328742027282715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000459","node_attrs":{"div":29,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BS.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BS.1"},"ace2_binding":{"value":"0.66194"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-12"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.49181526572268314"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"BS.1.1"},"ace2_binding":{"value":"0.6589000000000002"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.6029918987948071"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"BS.1.2"},"ace2_binding":{"value":"0.66821"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.4975483601650658"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"internal_a315","node_attrs":{"div":26,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BA.2.3.20"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CM.10"},"ace2_binding":{"value":"0.8190299999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7593324873420084"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000461","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.4"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.4"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.4.1"},"ace2_binding":{"value":"0.91683"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7016283989012374"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.6"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.6"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.6.1"},"ace2_binding":{"value":"0.9440299999999998"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8143059671640498"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000463","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.5"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.5.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.5.2"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"CM.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CM.5"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.8"},"ace2_binding":{"value":"0.99403"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7255583352017505"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000465","node_attrs":{"div":30,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.8.1"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CM.8.1.2"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CM.8.1.4"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000466","node_attrs":{"div":31,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CM.8.1.5"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"CM.8.1.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.8.1.3"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"NODE_0000467","node_attrs":{"div":35,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.8.1.1"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FV.1"},"ace2_binding":{"value":"0.28625999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0761544902802131"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.12"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.11"},"ace2_binding":{"value":"0.35566999999999993"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0179803928276123"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.3"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.9"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.2"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.2.1"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000470","node_attrs":{"div":29,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.7"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.7"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000471","node_attrs":{"div":30,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.7.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"CM.7.1.1"},"ace2_binding":{"value":"0.9729599999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9785485534494837"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}},{"name":"CM.7.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.7.1"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000472","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.1293535232543945}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.17"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.112788200378418}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.21"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.37"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.1010122299194336}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.57"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.166472434997559}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.66"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.675938129425049}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.68"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9366536140441895}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.73"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.040555000305176}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.74"},"ace2_binding":{"value":"0.21698000000000003"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.33134042675697756"},"placement_prior":{"value":-3.888690233230591}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.78"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.6647868156433105}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000473","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0962488651275635}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.67"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000474","node_attrs":{"div":6,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"placement_prior":{"value":-4.71979284286499}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79.1","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.79.1"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}},{"name":"BA.2.79","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.79"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"placement_prior":{"value":-4.71979284286499}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000475","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"placement_prior":{"value":-3.6624863147735596}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.76"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-3.6624863147735596}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000476","node_attrs":{"div":6,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.76.2"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.76.1"},"ace2_binding":{"value":"0.18492"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.2640232066165751"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}}]}]},{"name":"NODE_0000477","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-3.4443867206573486}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.38"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.4443867206573486}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"placement_prior":{"value":-4.741133213043213}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.38.3"},"ace2_binding":{"value":"0.08445999999999997"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.07383293656037815"},"placement_prior":{"value":-4.741133213043213}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BH.1"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.370455061085298"},"placement_prior":{"value":-4.580904006958008}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"internal_ab43","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-3.989638090133667}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.38.1"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.08612585067749}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-4.910482883453369}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.38.2"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.38.4"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.449790954589844}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"placement_prior":{"value":-3.7970614433288574}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.12"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7970614433288574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.12.2"},"ace2_binding":{"value":"0.07350000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.062348652344665065"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000482","node_attrs":{"div":5,"clade_nextstrain":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"placement_prior":{"value":-3.0566976070404053}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.12.1"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.0566976070404053}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000483","node_attrs":{"div":7,"clade_nextstrain":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"placement_prior":{"value":-1.82924222946167}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BG.2"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-18"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BG.1"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.3","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BG.3"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.567026138305664}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.4","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BG.4"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.5","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BG.5"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-07-28"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.7","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BG.7"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.6","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BG.6"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-08-01"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}}]}]}]},{"name":"NODE_0000484","node_attrs":{"div":18,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"placement_prior":{"value":-3.860531806945801}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BA.2.75"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-3.860531806945801}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.10"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.499698638916016}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BA.2.75.8"},"ace2_binding":{"value":"1.04854"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.7"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-4.541248321533203}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"placement_prior":{"value":-5.736501216888428}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.9"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.736501216888428}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"CB.1"},"ace2_binding":{"value":"0.81858"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.514633655548096}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.4"},"ace2_binding":{"value":"1.13451"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000487","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.2"},"ace2_binding":{"value":"0.7472099999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.2.1"},"ace2_binding":{"value":"0.7472099999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-3.378986358642578}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.3"},"ace2_binding":{"value":"1.24593"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5588825437629772"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000489","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BR.1"},"ace2_binding":{"value":"0.9449499999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.1.1"},"ace2_binding":{"value":"0.9449499999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.1.2"},"ace2_binding":{"value":"0.12575999999999996"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7451886007636047"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000490","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BR.4"},"ace2_binding":{"value":"1.10514"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5013910005227346"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000491","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.5"},"ace2_binding":{"value":"1.03573"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BR.5.1"},"ace2_binding":{"value":"1.03573"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.1"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.4"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000493","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"placement_prior":{"value":-4.207220554351807}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.5"},"ace2_binding":{"value":"1.16854"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000494","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BL.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.2.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000495","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BL.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.1.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.1.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.1.3"},"ace2_binding":{"value":"1.19193"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.1.4"},"ace2_binding":{"value":"1.3464399999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BL.1.5"},"ace2_binding":{"value":"0.56756"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6011952983295785"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.6"},"ace2_binding":{"value":"1.11979"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5544855553668998"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"placement_prior":{"value":-4.681202411651611}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.6"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.681202411651611}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"placement_prior":{"value":-4.277714252471924}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BY.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.277714252471924}},"branch_attrs":{"mutations":{}}},{"name":"internal_147e","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BY.1.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BY.1.2.1"},"ace2_binding":{"value":"0.41646999999999995"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_1967","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"placement_prior":{"value":-5.0982890129089355}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BY.1.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-5.0982890129089355}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BY.1.1.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BA.2.75.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CA.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CA.2"},"ace2_binding":{"value":"0.41646999999999995"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-4.7165374755859375}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.4","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CA.4"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.7"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.5"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CA.6"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CA.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CA.3.1"},"ace2_binding":{"value":"0.2371799999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}},{"name":"CA.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.3"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"placement_prior":{"value":-4.096994876861572}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.5"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.096994876861572}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.4"},"ace2_binding":{"value":"1.14197"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"placement_prior":{"value":-4.784391403198242}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.6"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.629100799560547}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.5"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.532908916473389}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.2"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.2.1"},"ace2_binding":{"value":"1.14197"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.3.1"},"ace2_binding":{"value":"1.08339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.653690335850791"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.3"},"ace2_binding":{"value":"1.11385"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5060716304521155"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000505","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.10"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.11"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.7","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.8"},"ace2_binding":{"value":"0.5340599999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9193315170816834"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"internal_5f66","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.1"},"ace2_binding":{"value":"1.2021600000000001"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.1.1"},"ace2_binding":{"value":"1.2021600000000001"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000507","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000508","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.5.2"},"ace2_binding":{"value":"1.1331"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7470314258752732"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.5.1"},"ace2_binding":{"value":"1.31233"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7815531080803261"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.1.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.4.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.4.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"NODE_0000510","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"BN.1.4.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"BN.1.4.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}},{"name":"BN.1.4.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.4.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}}]}]},{"name":"NODE_0000511","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"placement_prior":{"value":-5.13617467880249}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.9"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.220160961151123}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000512","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.2.1"},"ace2_binding":{"value":"1.21326"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7326886306518271"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.2.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.8"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000513","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FR.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000514","node_attrs":{"div":31,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FR.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FR.1.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FR.1.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FR.1.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000515","node_attrs":{"div":35,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FR.1.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}},{"name":"FR.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FR.1.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-4.497981071472168}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.4"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"DS.1"},"ace2_binding":{"value":"1.16291"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0513083167390975"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"DS.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"DS.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.10"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.12","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.12"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.1.3.2"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.9"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.8"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EJ.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EJ.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.3","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EJ.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-3.269749402999878}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.1.3.11"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.13"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-08-06"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.880107879638672}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000522","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"placement_prior":{"value":-4.307699680328369}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.307699680328369}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.5"},"ace2_binding":{"value":"1.15852"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"placement_prior":{"value":-5.031914710998535}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BM.6"},"ace2_binding":{"value":"1.15852"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"NODE_0000523","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.2.2"},"ace2_binding":{"value":"1.26994"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5272935807019111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.2.1"},"ace2_binding":{"value":"0.81858"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.2.3"},"ace2_binding":{"value":"0.78817"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.1"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.1.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000527","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"BM.1.1.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BM.1.1.5"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.992039680480957}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.1.1.1"},"ace2_binding":{"value":"0.43724"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CJ.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"internal_ed55","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.1"},"ace2_binding":{"value":"0.87567"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9457248359372292"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000531","node_attrs":{"div":28,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CJ.1.3"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.3.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.3.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000532","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000533","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.1.1.3"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CV.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CV.2"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-06"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000534","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BM.1.1.4"},"ace2_binding":{"value":"0.46466000000000013"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000535","node_attrs":{"div":29,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EP.2"},"ace2_binding":{"value":"0.46466000000000013"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000536","node_attrs":{"div":35,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"EP.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EP.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000537","node_attrs":{"div":39,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"EP.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EP.1.1.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}},{"name":"EP.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EP.1.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.4"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.4.1"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.4.1.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CH.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000541","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"placement_prior":{"value":-5.852805137634277}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CH.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CH.3"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"CH.3.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CH.3.1"},"ace2_binding":{"value":"1.0219999999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CH.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CH.1"},"ace2_binding":{"value":"0.36891999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7685109779549473"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000544","node_attrs":{"div":25,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.27"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.7"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000545","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.18"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":29,"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.21"},"ace2_binding":{"value":"0.08511000000000003"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:59-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9441222497200389"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000546","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000547","node_attrs":{"div":31,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"GQ.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GQ.1"},"ace2_binding":{"value":"0.9334899999999999"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GQ.1.1"},"ace2_binding":{"value":"0.9334899999999999"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000548","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-3.513967990875244}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.10"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.15"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.24"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.26"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.25"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.29"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"internal_ddb1","node_attrs":{"div":29,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"DV.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000550","node_attrs":{"div":31,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.8"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"DV.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.3.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"DV.6"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.6.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}},{"name":"DV.6.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.6.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.7"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"DV.7.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000557","node_attrs":{"div":40,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"DV.7.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"DV.7.1.8"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000558","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.6"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"DV.7.1.7"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.2"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"JV.1"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"JV.2"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000561","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.5"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KG.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"KG.2"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000562","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.4"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.3"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.9"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000563","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.28"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.32"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000564","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.13"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.14"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.9"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000565","node_attrs":{"div":27,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.11"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GP.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GP.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GP.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000566","node_attrs":{"div":27,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-3.320462703704834}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.16"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.20"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.23"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.22"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.30"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.8"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.6"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"NODE_0000567","node_attrs":{"div":30,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.12"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FS.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000568","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.19"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FJ.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000569","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.31"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000570","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"JP.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JP.1"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:62-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JP.1.1"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:62-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.17"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000572","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FK.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-31"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.2.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"FK.1.2.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000574","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FK.1.4.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000576","node_attrs":{"div":37,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"FK.1.1.1"},"ace2_binding":{"value":"0.16085999999999998"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9815994835819151"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FK.1.3.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000579","node_attrs":{"div":43,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"placement_prior":{"value":-4.664889812469482}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.3.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.664889812469482}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JL.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000580","node_attrs":{"div":48,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"LV.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LV.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000581","node_attrs":{"div":50,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"placement_prior":{"value":-4.55715799331665}},"branch_attrs":{"mutations":{"nuc":["C21T","T13339C"]}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-08-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.55715799331665}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"BA.2.86.4"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.5"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000582","node_attrs":{"div":52,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86.6"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"LV.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}}]},{"name":"NODE_0000583","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.7"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-13"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000584","node_attrs":{"div":58,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"MP.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"MP.1"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"MP.1.1"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.6738025507980547"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JQ.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000586","node_attrs":{"div":56,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JQ.2"},"ace2_binding":{"value":"1.15919"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-05"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000587","node_attrs":{"div":60,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JQ.2.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-20"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JQ.2.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JQ.2.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000588","node_attrs":{"div":52,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-5.804113388061523}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.4"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.519156455993652}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000589","node_attrs":{"div":53,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-3.827300786972046}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-3.827300786972046}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.12"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.15","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.15"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.14","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.14"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.18","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.18"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.17","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.17"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.16","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.16"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.19","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.19"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.6"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.381936550140381}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.8","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.8"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.9","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.9"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.700376033782959}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.7","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.7"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"NODE_0000590","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.11"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.11"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.11.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000591","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.13"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.13"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.13.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000592","node_attrs":{"div":56,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","C6525T","C29171T"],"N":["H300Y"],"ORF1a":["P892S","T2087I"]},"labels":{"aa":"N: H300Y; ORF1a: P892S, T2087I"}},"children":[{"name":"JN.3.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.3.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.3.2.1"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]},{"name":"NODE_0000593","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.5"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.5.1"},"ace2_binding":{"value":"0.6465599999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}},{"name":"JN.5","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.5"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000594","node_attrs":{"div":55,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.3","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.3.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"JN.3.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.3.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}}]},{"name":"internal_59b29264","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.3","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.4"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000596","node_attrs":{"div":58,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.2.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.2.2.1"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000597","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-4.352321624755859}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.10"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.503751754760742}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000598","node_attrs":{"div":58,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-2.788231134414673}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-09-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-2.788231134414673}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.10"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.4109206199646}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.12"},"ace2_binding":{"value":"0.26806999999999986"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.2179718017578125}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.17"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.394025802612305}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.19"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.904604911804199}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.21","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.21"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.875519275665283}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.22"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.6741983890533447}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.493799686431885}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.31"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.34"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.491109848022461}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.37"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.408229351043701}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.40"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.050711631774902}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.45"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.297847270965576}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.46"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.232522487640381}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.804265260696411}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.52"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.117598056793213}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.61","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.61"},"ace2_binding":{"value":"0.93036"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.496607246855186"},"placement_prior":{"value":-4.409794807434082}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.62","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.62"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.60","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.60"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.342294692993164}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.66","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"JN.1.66"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"placement_prior":{"value":-4.108686923980713}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.2.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.971951484680176}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.108686923980713}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000600","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.33249568939209}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.20","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.20"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.33249568939209}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.250879764556885}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.23"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"placement_prior":{"value":-5.240912914276123}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"JN.1.23.1"},"ace2_binding":{"value":"2.21099"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.23"},"ace2_binding":{"value":"2.21099"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"placement_prior":{"value":-5.240912914276123}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.24"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"placement_prior":{"value":-5.013424396514893}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.24"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.013424396514893}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.24.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.24.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.323510646820068}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.32"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"placement_prior":{"value":-4.1628737449646}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.32"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.1628737449646}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.32.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.261566638946533}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.38"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"placement_prior":{"value":-4.847131252288818}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.38.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.38"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.847131252288818}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.43"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"placement_prior":{"value":-4.390970706939697}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.43"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.390970706939697}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.43.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.44"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"placement_prior":{"value":-4.742091655731201}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.44"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.742091655731201}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.44.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.850801944732666}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.54"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"placement_prior":{"value":-5.474041938781738}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.54"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.474041938781738}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.54.1"},"ace2_binding":{"value":"0.05681999999999991"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.532734695870142"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.56"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"placement_prior":{"value":-4.913116455078125}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.56"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.913116455078125}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.56.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.56.1"},"ace2_binding":{"value":"0.7602899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5395016697354735"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","-23009G","A23012-"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"placement_prior":{"value":-4.234557628631592}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.234557628631592}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.6.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.4928669929504395}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.59"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"placement_prior":{"value":-4.803600311279297}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.59.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"qc.overallScore":{"value":8.507},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}},{"name":"JN.1.59","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.59"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.803600311279297}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000611","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.63"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"placement_prior":{"value":-5.165487766265869}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.63"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.165487766265869}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.63.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.744463920593262}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"placement_prior":{"value":-6.049203395843506}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.25"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.049203395843506}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"placement_prior":{"value":-6.251752853393555}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.25.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.251752853393555}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LM.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"placement_prior":{"value":-4.3950371742248535}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.29"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3950371742248535}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.29.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MJ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.455280065536499}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.41"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.36"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"placement_prior":{"value":-5.332466125488281}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.36.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.063255786895752}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.36","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.36"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.332466125488281}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.47"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"placement_prior":{"value":-5.005919456481934}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.47"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.005919456481934}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.47.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.47.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.993666172027588}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"placement_prior":{"value":-5.404429912567139}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.51"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.404429912567139}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"placement_prior":{"value":-5.081503391265869}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.51.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.081503391265869}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LJ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"placement_prior":{"value":-4.514355659484863}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.55"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.514355659484863}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"placement_prior":{"value":-5.77592134475708}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.55.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.55.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"NODE_0000623","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"placement_prior":{"value":-4.698468208312988}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":59,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.67"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.698468208312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000624","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.67.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MZ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"placement_prior":{"value":-3.8991429805755615}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.39.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.853466033935547}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"JN.1.39","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.39"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.8991429805755615}},"branch_attrs":{"mutations":{}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"placement_prior":{"value":-4.175995826721191}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.39.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.563828945159912}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.39.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"placement_prior":{"value":-3.966954231262207}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.42"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.966954231262207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.42.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.303705215454102}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"placement_prior":{"value":-5.334356784820557}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.42.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.334356784820557}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"MS.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.50.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.50","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.50"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.50.2"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"ME.1"},"ace2_binding":{"value":"0.27215999999999985"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"placement_prior":{"value":-4.891570091247559}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.53"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.891570091247559}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"placement_prior":{"value":-5.835316181182861}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.53.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.835316181182861}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000633","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LN.1.1"},"ace2_binding":{"value":"0.2595099999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}},{"name":"LN.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"LN.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.65"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.65.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MF.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MF.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"placement_prior":{"value":-4.343825817108154}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.30"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.343825817108154}},"branch_attrs":{"mutations":{}}},{"name":"internal_dafb7842","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"placement_prior":{"value":-5.548880577087402}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.30.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.548880577087402}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"KU.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.693577289581299}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KU.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"placement_prior":{"value":-6.125247478485107}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KU.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KU.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.2","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KU.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.956709861755371}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.35"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.48"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000641","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.48.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"internal_137393d6","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"JN.1.48.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.48.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LD.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_566939b0","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"placement_prior":{"value":-4.3079633712768555}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.58"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3079633712768555}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.40906286239624}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"placement_prior":{"value":-5.875661849975586}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.875661849975586}},"branch_attrs":{"mutations":{}}},{"name":"LR.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LR.2"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}},{"name":"LR.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LR.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.469166278839111}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LR.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"NODE_0000646","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"placement_prior":{"value":-4.500974178314209}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.8"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.500974178314209}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.8.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"internal_edd3fce6","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"placement_prior":{"value":-4.438825607299805}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000648","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KY.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"placement_prior":{"value":-4.780362606048584}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.15"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.780362606048584}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"placement_prior":{"value":-5.424458980560303}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.15.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.424458980560303}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"placement_prior":{"value":-5.752961158752441}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LU.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LU.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2.2","node_attrs":{"div":71,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LU.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"LU.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LU.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LU.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LU.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.396687030792236}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":96},"Nextclade_pango":{"value":"LU.2.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000654","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"placement_prior":{"value":-4.625055313110352}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.28"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.625055313110352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000655","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.28.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"KW.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KW.1.2"},"ace2_binding":{"value":"0.9318500000000001"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3745641202332524"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000657","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KW.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000658","node_attrs":{"div":68,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KW.1.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LG.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"placement_prior":{"value":-4.775076866149902}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.49.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.329537868499756}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.49"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.775076866149902}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"placement_prior":{"value":-5.515918254852295}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.49.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MB.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000662","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MB.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000663","node_attrs":{"div":68,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MB.1.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MV.1"},"ace2_binding":{"value":"0.30217999999999995"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"placement_prior":{"value":-4.533131122589111}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.64"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.533131122589111}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"placement_prior":{"value":-5.344335556030273}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.64.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.344335556030273}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MD.2"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MD.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"placement_prior":{"value":-5.915351390838623}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MD.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.915351390838623}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MD.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MD.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"MD.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"MD.3.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MD.3.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.229307174682617}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.26"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.005617618560791}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000669","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.9326608180999756}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.14"},"ace2_binding":{"value":"1.02389"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.27"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.131450176239014}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.13"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.13.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KS.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KS.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KS.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KS.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KS.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.098633766174316}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.57"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.57"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.57.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.1"},"ace2_binding":{"value":"1.08313"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.566636085510254}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.6906843185424805}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.1756510734558105}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.7.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.7.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000676","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.8"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000677","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MQ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}},{"name":"MQ.2","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MQ.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.7.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LK.1"},"ace2_binding":{"value":"1.04395"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LK.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LK.2.1"},"ace2_binding":{"value":"0.95433"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LK.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"placement_prior":{"value":-3.712366819381714}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.712366819381714}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.77679967880249}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.4"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.743769645690918}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.8"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KQ.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000682","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"placement_prior":{"value":-2.8164637088775635}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.036896228790283}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LL.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KV.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KV.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"placement_prior":{"value":-4.782667636871338}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.782667636871338}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.2"},"ace2_binding":{"value":"1.02389"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000686","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LE.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"placement_prior":{"value":-5.76973295211792}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"LE.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LE.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.76973295211792}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LE.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.145851135253906}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"NODE_0000687","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LE.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.1.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LE.1.3.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"placement_prior":{"value":-3.5281527042388916}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.5281527042388916}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.900146961212158}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.1.8"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000689","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LT.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"placement_prior":{"value":-5.643091678619385}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.643091678619385}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LC.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"placement_prior":{"value":-4.972570896148682}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.972570896148682}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"placement_prior":{"value":-5.62172794342041}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KZ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.62172794342041}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KZ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KZ.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000694","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"placement_prior":{"value":-3.322723865509033}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.10","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1.10"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.8855814933776855}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.391621112823486}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.850395679473877}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1.9"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000695","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.5"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KR.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.5"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000696","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KR.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.4"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.4.1"},"ace2_binding":{"value":"0.2408299999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"qc.overallScore":{"value":11.111},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000697","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KR.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.3","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"KR.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"NODE_0000698","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"placement_prior":{"value":-4.0566229820251465}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.9"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.0566229820251465}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.9.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.607508659362793}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"placement_prior":{"value":-5.146241664886475}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.9.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.146241664886475}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"placement_prior":{"value":-3.996425151824951}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LB.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.996425151824951}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.6","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.9","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LB.1.9"},"ace2_binding":{"value":"0.2408299999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"LB.1.8","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"NODE_0000701","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.3","node_attrs":{"div":67,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.4.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-24"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000702","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.662420749664307}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.7.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.7.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.7.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000704","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.3.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.3.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.472050666809082}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.3.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MH.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000706","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"placement_prior":{"value":-3.9273574352264404}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.16"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-3.9273574352264404}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.16.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.347455024719238}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"placement_prior":{"value":-5.415005207061768}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.16.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.415005207061768}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LA.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LA.2"},"ace2_binding":{"value":"0.04741999999999978"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000709","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"placement_prior":{"value":-4.693892955780029}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.16.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.026412010192871}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.16.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MT.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"NODE_0000711","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"placement_prior":{"value":-4.084128379821777}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.16.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.084128379821777}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LF.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"LF.7"},"ace2_binding":{"value":"0.21767999999999987"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"qc.overallScore":{"value":50.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.817229820305529"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LF.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3.1.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000717","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"placement_prior":{"value":-5.651890277862549}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":61,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.9"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.651890277862549}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000718","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"placement_prior":{"value":-5.674976825714111}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":62,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.9.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.674976825714111}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000719","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000720","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.8.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.8.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}},{"name":"LF.8.1.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LF.8.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"placement_prior":{"value":-4.10247802734375}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.18"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.10247802734375}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.8"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"placement_prior":{"value":-4.954190254211426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.954190254211426}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LS.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"placement_prior":{"value":-5.688791275024414}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.688791275024414}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LH.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LH.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"placement_prior":{"value":-4.828893184661865}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.3"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.828893184661865}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MA.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"placement_prior":{"value":-7.243719577789307}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MA.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.795672416687012}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MA.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MA.1.1.1"},"ace2_binding":{"value":"0.3926199999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"qc.overallScore":{"value":11.111},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}},{"name":"MA.1.1","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MA.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"placement_prior":{"value":-5.446084976196289}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.446084976196289}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LQ.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"placement_prior":{"value":-5.52098274230957}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LQ.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LQ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LQ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LQ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"NODE_0000730","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"placement_prior":{"value":-5.107730865478516}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.18.7"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"MN.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"placement_prior":{"value":-5.1725053787231445}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.1725053787231445}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LY.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LY.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"NODE_0000733","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LZ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LZ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LZ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]},{"name":"NODE_0000735","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LZ.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LZ.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}},{"name":"LZ.2.1","node_attrs":{"div":65,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LZ.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.11"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"placement_prior":{"value":-4.8429436683654785}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.11"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.8429436683654785}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.11.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.5"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.6"},"ace2_binding":{"value":"0.04741999999999978"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.00890588760376}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KP.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000739","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.2"},"ace2_binding":{"value":"0.27333999999999997"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7741516492587035"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.4.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.4.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"KP.4.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"internal_7da46150","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"KP.4.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}},{"name":"KP.4.2.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.4.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]}]}]},{"name":"NODE_0000743","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-02-22"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"MG.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"MU.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"LP.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"internal_bfd296bd","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LP.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000749","node_attrs":{"div":67,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.2","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LP.1.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]}]}]}]},{"name":"NODE_0000750","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2.10","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.10"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.11","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.11"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.616637706756592}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.12","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.12"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.14"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.19"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2.24"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.23"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.9"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2.15"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.15.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.20"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.20.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.20.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.096656799316406}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000754","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.1"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7908990401504723"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.3.4"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"NODE_0000755","node_attrs":{"div":67,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":96},"Nextclade_pango":{"value":"MW.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000756","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"placement_prior":{"value":-3.916172504425049}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.13"},"ace2_binding":{"value":"0.21942999999999988"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.16"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.532754898071289}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.17","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.17"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.18","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.18"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.22"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.321987628936768}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000757","node_attrs":{"div":63,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"KP.3.4.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3.2","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.3.2"},"ace2_binding":{"value":"-1.15242"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5554650921238282"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"KP.3.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.3.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"NODE_0000760","node_attrs":{"div":68,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.3.3.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MR.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.3.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.2","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"ML.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"ML.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"ML.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.4867472648620605}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-09"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.350050449371338}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000764","node_attrs":{"div":70,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"LW.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LW.1.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LW.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.2","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LW.1.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000765","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.1.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.7"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.8"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MY.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MM.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MM.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000768","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.1.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MK.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MK.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"MK.3"},"ace2_binding":{"value":"-1.11924"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7206397516519647"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.3.1.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000770","node_attrs":{"div":67,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.10"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.12"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.14"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.02898645401001}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.16","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.16"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.910944700241089}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.15","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.15"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.3","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.6","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.3801984786987305}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.4","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.5","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.7","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.7"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5369762101413171"},"placement_prior":{"value":-6.544749736785889}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.9"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.347929000854492}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000771","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.11"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.11.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000772","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.13"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.13.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.2.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.050478935241699}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}},{"name":"MC.2","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.8.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}},{"name":"MC.8","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.8"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-3.5445594787597656}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000776","node_attrs":{"div":5,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-4.484652996063232}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.4.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.484652996063232}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000777","node_attrs":{"div":6,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000778","node_attrs":{"div":7,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-2.9143002033233643}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.222130537033081}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.3","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.5","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.7"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.027554035186768}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000779","node_attrs":{"div":10,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"placement_prior":{"value":-2.785705327987671}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.1","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-09-05"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9799063205718994}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-2.785705327987671}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.4.6.3"},"ace2_binding":{"value":"0.71883"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.2","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.4.6.2"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9107766151428223}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000780","node_attrs":{"div":11,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DC.1"},"ace2_binding":{"value":"0.66094"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000781","node_attrs":{"div":7,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-05-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7295260429382324}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.1.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"22A"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.8587093353271484}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.9"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000782","node_attrs":{"div":8,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.4.1.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000783","node_attrs":{"div":9,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BA.4.1.11"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000784","node_attrs":{"div":11,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.4.1.10"},"ace2_binding":{"value":"0.67074"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5308081831240151"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CS.1"},"ace2_binding":{"value":"0.5702799999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.7561969850799493"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000785","node_attrs":{"div":12,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-3.195547103881836}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.195547103881836}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.9"},"ace2_binding":{"value":"0.39901000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.2395057678222656}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"NODE_0000786","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-4.000418663024902}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"ORF1a":["M2096L"]},"labels":{"aa":"ORF1a: M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000787","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"placement_prior":{"value":-2.946962833404541}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.946962833404541}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.5.2","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.5.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.243049144744873}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"NODE_0000788","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"placement_prior":{"value":-2.891695499420166}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.5.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-3.5131309032440186}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"placement_prior":{"value":-3.0766263008117676}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0766263008117676}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000790","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"placement_prior":{"value":-3.1130268573760986}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.6.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9632551670074463}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.6.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.4","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.6.4"},"ace2_binding":{"value":"0.5883099999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000791","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.6.2"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BW.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BW.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BW.1.2"},"ace2_binding":{"value":"0.6570799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000793","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BW.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BW.1.1.1"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BW.1.1.2"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BW.1.1"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000794","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-2.2668097019195557}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"]}},"children":[{"name":"BA.5.1","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.5.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.2668097019195557}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.12"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.4273552894592285}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.11","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.14","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.14"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.96599817276001}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.16"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.954094409942627}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.17"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7746376991271973}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2638373374938965}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.24"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3640358448028564}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.28"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.258039951324463}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.150360584259033}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.30"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.9021801948547363}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.34"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.1470396518707275}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.4","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.6","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.541717767715454}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.7","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.88628888130188}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.8","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6331071853637695}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0000795","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BK.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.15"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DL.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000797","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DH.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000798","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.26"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CU.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.303286075592041}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.1.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.38"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000800","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.1.33"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"EQ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_8226","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.35"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"EB.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_bae4","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"placement_prior":{"value":-3.846775770187378}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.23"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.846775770187378}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"placement_prior":{"value":-3.115823268890381}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DE.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"DE.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0000804","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.430187463760376}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.5.1.18"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000805","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"placement_prior":{"value":-4.06973934173584}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.06973934173584}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BT.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BT.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"placement_prior":{"value":-3.8074188232421875}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.25"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8074188232421875}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"placement_prior":{"value":-5.113685607910156}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"DJ.1"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.113685607910156}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000808","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"placement_prior":{"value":-5.255130290985107}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"DJ.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DJ.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000809","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DJ.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DJ.1.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.5218355655670166}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.27"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7831978797912598}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.29"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CL.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0000813","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"placement_prior":{"value":-4.229829788208008}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0000814","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-2.733313798904419}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0832855701446533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.0474534034729}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.32"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.180713653564453}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000815","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-4.133322715759277}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.20"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.535171985626221}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.36","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.36"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.37"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-3.151113748550415}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.793166160583496}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000818","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.5.10.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000819","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DF.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"DF.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DF.1.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0000820","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-3.7016499042510986}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7016499042510986}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000821","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.677614212036133}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.2.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.677614212036133}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BF.12"},"ace2_binding":{"value":"0.5279"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9531965255737305}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.14"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-3.077155351638794}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"ORF1b":["H1087Y"],"S":["N450D"]},"labels":{"aa":"ORF1b: H1087Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.19","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.17","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.17"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.485513687133789}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.18","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.18"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.091020107269287}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.30"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.33"},"ace2_binding":{"value":"0.6034899999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.5511837005615234}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9146251678466797}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.488147020339966}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000822","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.31"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"placement_prior":{"value":-4.266521453857422}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BF.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.266521453857422}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.31.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.39"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"placement_prior":{"value":-4.000523567199707}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.39.1"},"ace2_binding":{"value":"0.33263"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5959379308450252"},"placement_prior":{"value":-5.37965726852417}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.39"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.000523567199707}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.41"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"placement_prior":{"value":-4.131745338439941}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.41.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.41","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.41"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.131745338439941}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000825","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.462851524353027}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.11.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000826","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"placement_prior":{"value":-5.1659932136535645}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.292901039123535}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.11.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0000827","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.7677369117736816}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7894070148468018}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.28"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2664027214050293}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.35","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.35"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T9727C","C12789T","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"],"S":["N450D"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.36","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.36"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.462024211883545}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000828","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"placement_prior":{"value":-3.4317872524261475}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4317872524261475}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000829","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"placement_prior":{"value":-3.138411521911621}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.10.1"},"ace2_binding":{"value":"0.3218"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.563032084337257"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.138411521911621}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000830","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-3.120866537094116}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.15"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.382185459136963}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.20"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.540201187133789}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000831","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-3.864048957824707}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.27"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3812055587768555}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000832","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.4586398601531982}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.13"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.780573606491089}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.16"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.25"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.29"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.740543842315674}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.34"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-4.685749530792236}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.23"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.741713047027588}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"placement_prior":{"value":-4.337294578552246}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.337294578552246}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.3.1"},"ace2_binding":{"value":"0.48889999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.257171630859375}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000835","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-4.661863803863525}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.24"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000836","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-4.16046142578125}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.16046142578125}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000837","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-2.7555088996887207}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.5.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000838","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.266281604766846}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000839","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-2.605588436126709}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000840","node_attrs":{"div":25,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BF.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-08"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}}]}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.6039862632751465}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.42"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.397184133529663}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.26"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.32"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.257172107696533}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.37"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.416947364807129}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.40"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.287396192550659}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.38"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"placement_prior":{"value":-4.238620281219482}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.38.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.38"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.238620281219482}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.38.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}},{"name":"BF.38.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.38.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}}]},{"name":"NODE_0000844","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.10"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.11","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.12"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.15"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.17"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.18"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.20","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.20"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.21","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.21"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.2"},"ace2_binding":{"value":"0.6393200000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.22","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.22"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9261090755462646}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.26","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.26"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.24","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.24"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.23","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.23"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.092196941375732}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.9"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"BF.7.8","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000845","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.16"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.16.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000846","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.19"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.19"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.19.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0000847","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.5.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000848","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.13"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.13"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.13.1"},"ace2_binding":{"value":"0.6759999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.13.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}}]},{"name":"NODE_0000849","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BF.7.4.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000850","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.4.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.3122618198394775}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.4.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0000851","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.27"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000852","node_attrs":{"div":26,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BF.7.14.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.4","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.325514793395996}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0000853","node_attrs":{"div":27,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000854","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-2.6320736408233643}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.23"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.815145969390869}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.182581424713135}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.40"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.9923183917999268}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000855","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-1.9060567617416382}},"branch_attrs":{"mutations":{"nuc":["C16616A","C27012T","C27513T"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.12"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3895606994628906}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.14","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.14"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.13","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.13"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.6929638385772705}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.19","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7767930030822754}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.22","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4965717792510986}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.29","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.29"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.456769943237305}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.28","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.28"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.146134376525879}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.30","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.30"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.523482322692871}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.34","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.34"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.511476755142212}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.35"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.6543288230895996}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.37"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.394333839416504}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.39"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.5.2.42"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.43"},"ace2_binding":{"value":"0.5642800000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5413273873731987"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.44"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.278106212615967}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.46"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.212985038757324}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.45","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.45"},"ace2_binding":{"value":"0.5131699999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.998797416687012}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.54","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.54"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.164445877075195}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.53","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.53"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.224037170410156}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.52","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.52"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.105970859527588}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.55"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9875283241271973}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.59"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.192619323730469}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.5.2.58","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.58"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.236825942993164}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.57"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.694666862487793}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.62"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.162878036499023}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.61","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.61"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.711515426635742}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.63","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.5.2.63"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.8","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9411776065826416}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.285115718841553}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.32"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.365017890930176}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"placement_prior":{"value":-3.7827541828155518}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.27"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7827541828155518}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CF.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.796359539031982}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"NODE_0000858","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.33"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CE.1"},"ace2_binding":{"value":"0.39901000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3798828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"internal_1651","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"placement_prior":{"value":-4.1625542640686035}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.36"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.1625542640686035}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CT.1"},"ace2_binding":{"value":"0.4564899999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7208595659836455"},"placement_prior":{"value":-5.671617031097412}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"placement_prior":{"value":-4.313873291015625}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.38"},"ace2_binding":{"value":"0.56458"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.30660604695253"},"placement_prior":{"value":-4.313873291015625}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DA.1"},"ace2_binding":{"value":"0.6759999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"placement_prior":{"value":-5.4733147621154785}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000861","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.41"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.635266304016113}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.56"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.0257768630981445}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.47"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DQ.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000863","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"placement_prior":{"value":-3.0985805988311768}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.20"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0985805988311768}},"branch_attrs":{"mutations":{}}},{"name":"BV.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BV.2"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.277459144592285}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}},{"name":"BV.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BV.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}}]},{"name":"NODE_0000864","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"placement_prior":{"value":-3.4673714637756348}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4673714637756348}},"branch_attrs":{"mutations":{}}},{"name":"CN.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CN.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}},{"name":"CN.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"CN.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_6217","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BZ.2"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BZ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CD.1"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.5325236320495605}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CD.2"},"ace2_binding":{"value":"0.5594199999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3253063676642168"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0000867","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.49"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DZ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DZ.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]},{"name":"NODE_0000868","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.059089183807373}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.50"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.723017692565918}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.51","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.51"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.60"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000869","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.7"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CY.2"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CY.1"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.678462505340576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0000870","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-3.246659517288208}},"branch_attrs":{"mutations":{"nuc":["T27012C","T27513C"]}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.743002891540527}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6277518272399902}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000871","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"placement_prior":{"value":-3.8559513092041016}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.26"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8559513092041016}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CG.1"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]}]},{"name":"internal_a7d2","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.16"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BU.1"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.204470634460449}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BU.3"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}},{"name":"BU.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BU.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.25"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DB.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.356487274169922}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DB.2"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DB.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"DB.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}}]},{"name":"internal_93c4","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.18"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CR.2"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.905637264251709}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0000876","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"placement_prior":{"value":-4.66331672668457}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CR.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.66331672668457}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000877","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"placement_prior":{"value":-4.36233377456665}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CR.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CR.1.2"},"ace2_binding":{"value":"0.40216999999999997"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CR.1.3"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000878","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.48"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7050411701202393}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000879","node_attrs":{"div":25,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DY.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DY.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}}]},{"name":"NODE_0000880","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"placement_prior":{"value":-3.8912155628204346}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.5254948139190674}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7626357078552246}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"placement_prior":{"value":-3.2016091346740723}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.2016091346740723}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.3"},"ace2_binding":{"value":"0.38661"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-4.828918933868408}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.2"},"ace2_binding":{"value":"0.6942999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.5295255377787571"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.6","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.885843276977539}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.7","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CP.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.4","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.628321170806885}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.973639488220215}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"internal_7ebe","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CP.8"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"CP.8.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}}]},{"name":"NODE_0000883","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CP.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"CP.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.1.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-5.384389877319336}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.1.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.319447994232178}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}},{"name":"CP.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.1.3"},"ace2_binding":{"value":"0.6003199999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"internal_605c","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"placement_prior":{"value":-4.047678470611572}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.24"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.047678470611572}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.240954875946045}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CK.2"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"placement_prior":{"value":-4.374808311462402}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.2.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.374808311462402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000887","node_attrs":{"div":27,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CK.2.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DG.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0000888","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.068136215209961}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CK.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.068136215209961}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0000889","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.982324123382568}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CK.1.2"},"ace2_binding":{"value":"0.71883"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.998134136199951}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CK.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.711119651794434}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0000890","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.607345104217529}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.4"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.5"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0000891","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CK.1.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CK.1.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.657632827758789}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]},{"name":"NODE_0000892","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"placement_prior":{"value":-4.171703815460205}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"ORF1a":["Q556K"]},"labels":{"aa":"ORF1a: Q556K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.171703815460205}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF7a:72-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7826950550079346}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3075408935546875}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000893","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"placement_prior":{"value":-3.80965518951416}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9212589263916016}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.250945091247559}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}}]},{"name":"NODE_0000894","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{}}},{"name":"BE.3","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2200913429260254}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000895","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.430433750152588}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.10"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.9"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.668551206588745}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000896","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.247138023376465}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-","T28693C"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.13"},"ace2_binding":{"value":"0.5231200000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.5088823627149919"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":1},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.8"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":94},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]},{"name":"NODE_0000897","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-3.7212204933166504}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.12","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.12"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.008347988128662}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0000898","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.290442943572998}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T"],"ORF1a":["M85-"]},"labels":{"aa":"ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.6"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.737891674041748}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.395222187042236}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000899","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.679184913635254}},"branch_attrs":{"mutations":{"nuc":["C13342T"]}},"children":[{"name":"BE.2","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8559343814849854}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G"],"ORF1a":["T882I"]},"labels":{"aa":"ORF1a: T882I"}}},{"name":"NODE_0000900","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{"nuc":["C10188A","C27800T"],"ORF1a":["T3308N"]},"labels":{"aa":"ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000901","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"placement_prior":{"value":-4.281903266906738}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.4.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.614480018615723}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000902","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.4.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000903","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.4.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"CQ.2"},"ace2_binding":{"value":"0.40216999999999997"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"placement_prior":{"value":-3.9200549125671387}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000904","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CQ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CQ.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CQ.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000905","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"placement_prior":{"value":-3.0249295234680176}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"ORF1b":["M1156I"]},"labels":{"aa":"ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0249295234680176}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BE.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000906","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"placement_prior":{"value":-4.295778751373291}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.295778751373291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000907","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.1.2.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"DW.1"},"ace2_binding":{"value":"0.49383999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8224959014481948"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000908","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.4.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.1.4.3"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0000909","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"placement_prior":{"value":-4.36769437789917}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.4.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BE.1.4.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000910","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"placement_prior":{"value":-2.7709972858428955}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.7709972858428955}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000911","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CC.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000912","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"placement_prior":{"value":-4.0404744148254395}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.1.1"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.0404744148254395}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BQ.2"},"ace2_binding":{"value":"0.45205000000000006"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5680790723509552"},"placement_prior":{"value":-4.677975654602051}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000913","node_attrs":{"div":21,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-3.3798208236694336}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.3798208236694336}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.12"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.383481740951538}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.14"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4368515014648438}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.17"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.728248596191406}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.19"},"ace2_binding":{"value":"0.6127800000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7257362514460642"},"placement_prior":{"value":-4.9549241065979}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.20"},"ace2_binding":{"value":"0.5446"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8308113969466171"},"placement_prior":{"value":-4.456951141357422}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.21"},"ace2_binding":{"value":"0.6570799999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.24"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.423928260803223}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.31"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.428604602813721}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.32"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.33"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.945977687835693}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.5"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4588372707366943}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.4"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.7"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.903951168060303}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.6"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9833500385284424}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.9"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.657703399658203}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000914","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.11"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.11.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000915","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.13.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}},{"name":"BQ.1.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.13"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000916","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.29","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.29"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}},{"name":"BQ.1.28","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.28"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}}]},{"name":"NODE_0000917","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"placement_prior":{"value":-4.865876197814941}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.15"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.865876197814941}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"placement_prior":{"value":-4.009592056274414}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.15.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.111164569854736}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}},{"name":"BQ.1.15.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.15.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.30"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"placement_prior":{"value":-4.176229953765869}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.25"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.176229953765869}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.25.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8304200172424316}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000921","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"placement_prior":{"value":-5.710468292236328}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.26"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.710468292236328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000922","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.26.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.26.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000923","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.3.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.3.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.10"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"internal_fdc9","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.2"},"ace2_binding":{"value":"0.6353800000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6853534127590314"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EC.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EC.1.1"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"EC.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EC.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.2.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.687568426132202}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"internal_dbfb","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.2.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FB.2"},"ace2_binding":{"value":"0.5174000000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6925976779449897"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}},{"name":"FB.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FB.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}}]},{"name":"NODE_0000930","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JH.1"},"ace2_binding":{"value":"0.66664"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9874397743924017"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000931","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BQ.1.2.2"},"ace2_binding":{"value":"0.60833"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9373817650831857"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JH.2"},"ace2_binding":{"value":"0.6059300000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"frameShifts":{"value":"ORF7a:83-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":31},"immune_escape":{"value":"1.0821590912755812"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-2.758084297180176}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.16","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.16"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.18","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.18"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.5462334156036377}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.23"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4519829750061035}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.22"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.056916236877441}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.27"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-4.634747505187988}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.8"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.8.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.8.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FF.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000935","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-2.3916101455688477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1.11","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.11"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-3.890984058380127}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-2.3916101455688477}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.12"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-4.536876678466797}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.16"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.6093573570251465}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.17"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.1477370262146}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.19"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.224153995513916}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.20"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.21"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.24"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9906511306762695}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.25"},"ace2_binding":{"value":"0.7449699999999998"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9883317000263399"},"placement_prior":{"value":-4.071465015411377}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.26"},"ace2_binding":{"value":"0.5921799999999998"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8728938682420008"},"placement_prior":{"value":-4.841145992279053}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.30"},"ace2_binding":{"value":"0.60833"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9373817650831857"},"placement_prior":{"value":-4.599907875061035}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.31"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8225269317626953}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.34"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-5.100788593292236}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.36"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.200608253479004}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.37"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.312097549438477}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.42"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.227291584014893}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.41"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9046671390533447}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.40"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9314393997192383}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.45"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6982264518737793}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.47"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.249356746673584}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.44"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.04910135269165}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.50"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.385881423950195}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.51"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.995375394821167}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.55"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.858496189117432}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.57"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.359898567199707}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.58"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.377610206604004}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.56"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.5291290283203125}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.60"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.216671943664551}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.6"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.973461389541626}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.63"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.370896339416504}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.64"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.916772365570068}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.68"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.0179009437561035}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.67"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.056059837341309}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.66"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.271934509277344}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.69"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6361539363861084}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.70"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8411049842834473}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.73"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.75"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.051732686328446"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.76"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.239201068878174}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.77"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.6623735427856445}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.9"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.718957901000977}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"placement_prior":{"value":-5.200210094451904}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.14"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.200210094451904}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"CW.1"},"ace2_binding":{"value":"0.70602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-5.546139240264893}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000937","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"placement_prior":{"value":-3.995506525039673}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.15"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.995506525039673}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"DM.1"},"ace2_binding":{"value":"0.65602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"placement_prior":{"value":-4.960502624511719}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"placement_prior":{"value":-4.099379062652588}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-19"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.099379062652588}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DU.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000939","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.9369025230407715}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.23"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.7810332775115967}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.27"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.529773712158203}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000940","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.500676155090332}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.29"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.79"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.35"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"ET.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000942","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"placement_prior":{"value":-4.477259635925293}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.65"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.477259635925293}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"ES.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.6746344566345215}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000943","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"placement_prior":{"value":-3.848482608795166}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.7"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.848482608795166}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DK.1"},"ace2_binding":{"value":"0.74371"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-4.994816303253174}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"placement_prior":{"value":-4.450067520141602}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.72"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.450067520141602}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FC.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.900752067565918}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000945","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.8"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DP.1"},"ace2_binding":{"value":"0.66913"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9105813557217661"},"placement_prior":{"value":-4.242033958435059}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"placement_prior":{"value":-3.8017337322235107}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8017337322235107}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"CZ.1"},"ace2_binding":{"value":"0.6774299999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9883317000263399"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"CZ.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000947","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"placement_prior":{"value":-3.908764600753784}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.10"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.908764600753784}},"branch_attrs":{"mutations":{}}},{"name":"FA.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FA.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"FA.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"FA.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.795900344848633}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000948","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"placement_prior":{"value":-4.109678745269775}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.22"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.109678745269775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000949","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"ER.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"placement_prior":{"value":-4.9500412940979}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"ER.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ER.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.9500412940979}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000950","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"placement_prior":{"value":-3.677809476852417}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.677809476852417}},"branch_attrs":{"mutations":{}}},{"name":"DR.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DR.2"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.493982315063477}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"DR.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"DR.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.548750877380371}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}}]},{"name":"NODE_0000951","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.46"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000952","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EN.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EN.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EN.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000953","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.6486151218414307}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.48"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.381720066070557}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.49"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.766873836517334}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.78"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"placement_prior":{"value":-4.132527828216553}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.52"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.132527828216553}},"branch_attrs":{"mutations":{}}},{"name":"EA.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EA.2"},"ace2_binding":{"value":"0.34834999999999994"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.880706782961692"},"placement_prior":{"value":-4.9180803298950195}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}},{"name":"EA.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EA.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.47806978225708}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"placement_prior":{"value":-4.497543811798096}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.53"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.497543811798096}},"branch_attrs":{"mutations":{}}},{"name":"FM.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FM.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.829411506652832}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}},{"name":"FM.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FM.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"placement_prior":{"value":-3.49872088432312}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.18"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.49872088432312}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"ED.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6314659118652344}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ED.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.1880316734313965}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ED.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.8974103927612305}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000957","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.166533946990967}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.54"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.59"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000958","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"placement_prior":{"value":-4.4338603019714355}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.28"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.4338603019714355}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EH.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"placement_prior":{"value":-4.000490188598633}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.32"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.000490188598633}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DT.1"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DT.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.651244640350342}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DT.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.224050998687744}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"NODE_0000960","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{"nuc":["T7633C","C22314T","A24129G"],"S":["P251L","N856S"]},"labels":{"aa":"S: P251L, N856S","spike_mutations":"P251L, N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.38"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EW.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EW.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EW.3"},"ace2_binding":{"value":"0.65602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.116559982299805}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.62"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.4302690029144287}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.61"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000963","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.43"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EZ.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"placement_prior":{"value":-3.492278814315796}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.4"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.492278814315796}},"branch_attrs":{"mutations":{}}},{"name":"EE.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.131551265716553}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.184211254119873}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.4"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.840254783630371}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"EE.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.185059070587158}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.5"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.522100448608398}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}}]},{"name":"NODE_0000965","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"placement_prior":{"value":-4.684232711791992}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.74"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.684232711791992}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FN.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000966","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-6.281740188598633}},"branch_attrs":{"mutations":{"nuc":["C22314T","T23716C","A28834G"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000967","node_attrs":{"div":30,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BQ.1.1.39"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FQ.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-17"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000968","node_attrs":{"div":31,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.71"},"ace2_binding":{"value":"0.24659999999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EV.1"},"ace2_binding":{"value":"0.24659999999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0000969","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"placement_prior":{"value":-4.140890598297119}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.13"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.140890598297119}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.071533679962158}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000971","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"placement_prior":{"value":-4.138623237609863}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.22083044052124}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"placement_prior":{"value":-4.127103805541992}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.127103805541992}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000973","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.1.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EY.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000974","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.5"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6995480060577393}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000975","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"DN.3.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-7.322900772094727}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0000976","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"placement_prior":{"value":-4.858262538909912}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.858262538909912}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000977","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"DN.1.1.1"},"ace2_binding":{"value":"2.05606"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8990816968865659"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"DN.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.2"},"ace2_binding":{"value":"0.5626099999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8771384492554943"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.4"},"ace2_binding":{"value":"0.6722600000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8744814686582322"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MAHSNGTITVEELKKLLEEWNLVIGFLFLAWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFVRTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNKLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKDSCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTLVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDSLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNITLIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLFLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTIKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITTTQLPPAYTNSFTRGVYYPDKVFRSSVLHLTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVFIKVCEFQFCNDPFLDVYYHKNNKSWMESESGVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLGRDFPQGFSALEPLVDLPIGINITRFQTLLALNRSYLTPGDSSSGWTAGAADYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNVTNLCPFHEVFNATRFASVYAWNRTRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIKGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKHSGNYDYWYRLFRKSKLKPFERDISTEIYQAGNKPCKGVKGPNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTKSNKKFLPFQQFGRDIVDTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVSVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSRRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLFSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQLELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCTAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGATTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACATTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAGCCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACTTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTACTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTATTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAATAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAACGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCACAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCGCTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACTACAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTTAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTTTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTCAGGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGGGCGTGATTTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTAAATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGATTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATGTTACAAACTTGTGCCCTTTTCATGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGACGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAAAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGCATAGTGGTAATTATGATTACTGGTATAGATTGTTTAGGAAGTCTAAACTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAAAGGTGTTAAAGGTCCTAATTGTTACTTTCCTTTACAATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTAAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGTTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCTCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCGTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTTTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACTTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTATATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCACATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTGCATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTTCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGTGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACAAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/BA.2.86/tree.json.bak b/data/nextstrain/sars-cov-2/BA.2.86/tree.json.bak new file mode 100644 index 00000000..234a5c45 --- /dev/null +++ b/data/nextstrain/sars-cov-2/BA.2.86/tree.json.bak @@ -0,0 +1 @@ +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/BA.2.86/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{"nuc":["T21C","A897C","T3431G","G7842A","T8293C","A8393G","T11042G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12789C","C13339T","A15756T","G18492A","T21622C","C21624G","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21711C","T21941G","C22032T","A22033C","G22034A","T22208C","A22295C","A22353C","G22556A","C22577G","C22629A","A22770G","C22895G","A22896T","A22898G","G22910A","T22916C","G22917T","A22942T","A23005T","A23012G","A23013C","C23018T","C23019T","A23040G","A23222G","T23271C","T23423C","G23604A","T24378C","T24990C","T25207C","C26529G","G26610A","T26681C","T26833C","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28958C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["H3D","A30T","V104A"],"N":["E31-","R32-","S33-","K229Q"],"ORF1a":["D211A","L1056V","S2526N","T2710A","F3593V","S3675-","G3676-","F3677-","I4175T"],"ORF9b":["E27-","N28-","A29-"],"S":["T21R","L24-","P25-","P26-","A27S","L50S","F127V","S157F","G158R","F216L","N245H","D264A","V332I","H339D","T356K","K403R","H445V","S446G","D450N","W452L","K460N","K481N","K484A","P486F","Q493R","K554E","V570A","S621P","R681H","F939S","L1143P"]},"labels":{"aa":"M: H3D, A30T, V104A; N: E31-, R32-, S33-, K229Q; ORF1a: D211A, L1056V, S2526N, T2710A, F3593V, S3675-, G3676-, F3677-, I4175T; ORF9b: E27-, N28-, A29-; S: T21R, L24-, P25-, P26-, A27S, L50S, F127V, S157F, G158R, F216L, N245H, D264A, V332I, H339D, T356K, K403R, H445V, S446G, D450N, W452L, K460N, K481N, K484A, P486F, Q493R, K554E, V570A, S621P, R681H, F939S, L1143P","clade":"Omicron","spike_mutations":"T21R, L24-, P25-, P26-, A27S, L50S, F127V, S157F, G158R, F216L, N245H, D264A, V332I, H339D, T356K, K403R, H445V, S446G, D450N, W452L, K460N, K481N, K484A, P486F, Q493R, K554E, V570A, S621P, R681H, F939S, L1143P"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-5.175650596618652}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAA","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAA"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAC","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAC"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAF"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAB","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAB"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAE","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAE"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAD","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAD"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.87846565246582}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAG","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAG"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAJ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAJ"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.570775508880615}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAL","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAL"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAH","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAH"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.748638153076172}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAK","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAK"},"ace2_binding":{"value":"1.15166"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.3037714005953052"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAM","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAM"},"ace2_binding":{"value":"0.75567"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAN","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAN"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.081246852874756}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAR","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAR"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.453131198883057}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAQ","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XAQ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAP","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XAP"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-07-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.001843452453613}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAS","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XAS"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.453028202056885}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAT","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"XAT"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.875851631164551}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAV","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XAV"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.725754261016846}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":83,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XAW"},"ace2_binding":{"value":"0.91409"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.274687314409391"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E154-","S155-","F157S","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E154-, S155-, F157S, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E154-, S155-, F157S, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAU","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XAU"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.1733574867248535}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAZ","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"XAZ"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBA"},"ace2_binding":{"value":"0.20215999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":4},"immune_escape":{"value":"0.29808642936638835"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E154-","S155-","F157S","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBD"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"XBE"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.568921089172363}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBG","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"XBG"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBH"},"ace2_binding":{"value":"0.37244999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBM","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"XBM"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBN","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBN"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBP","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBP"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBQ"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBT"},"ace2_binding":{"value":"0.64255"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5037920175803539"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBS"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBR"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBV"},"ace2_binding":{"value":"0.32919999999999994"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBU","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBU"},"ace2_binding":{"value":"0.74825"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBW"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBY","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBY"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"XCB"},"ace2_binding":{"value":"1.41968"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XCA"},"ace2_binding":{"value":"0.74825"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XBZ","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBZ"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCC","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XCC"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCE"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XCD"},"ace2_binding":{"value":"0.95377"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XCG"},"ace2_binding":{"value":"1.16254"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCJ"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCK","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCK"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCM","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCM"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"XCN"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCL","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XCL"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCP","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCP"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCR","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XCR"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCQ","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCQ"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCS","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XCS"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCU","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCU"},"ace2_binding":{"value":"0.8835"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E154-","S155-","F157S","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XCV"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCW","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XCW"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCZ","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"XCZ"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XCY","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XCY"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XDB","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XDB"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XDC","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XDC"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XDE"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XDF"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDJ","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XDJ"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XDH"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XDG"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDN","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XDN"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDL","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XDL"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDM","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"XDM"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDS","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDS"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDS"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"XDT"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDU","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XDU"},"ace2_binding":{"value":"0.63761"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.9475349114594978"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDY","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XDY"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDW"},"ace2_binding":{"value":"1.15919"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XDZ","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDZ"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XE","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":48},"Nextclade_pango":{"value":"XE"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.6930429935455322}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEA","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XEA"},"ace2_binding":{"value":"1.41162"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2268340125514634"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEB","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XEB"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XED"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XED"},"qc.overallScore":{"value":17.361},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEE","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XEE"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEE"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.013909816741943}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XEG"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEG"},"qc.overallScore":{"value":950.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEF","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"XEF"},"ace2_binding":{"value":"-1.12538"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEF"},"qc.overallScore":{"value":34.028},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7268345560655398"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XG"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XG"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":9},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XH","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XH"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XK","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":45},"Nextclade_pango":{"value":"XK"},"ace2_binding":{"value":"-3.62446"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XJ","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XJ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XM","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":46},"Nextclade_pango":{"value":"XM"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-31"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XM"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.1486592292785645}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XL","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"XL"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XP","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XP"},"ace2_binding":{"value":"0.023200000000000068"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3616394203564539"},"placement_prior":{"value":-3.0015511512756348}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XN","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XN"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XN"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.342913627624512}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XR","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XR"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XQ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XQ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.572272300720215}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XV","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":47},"Nextclade_pango":{"value":"XV"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.516026020050049}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XT","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XT"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.084201812744141}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XW","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XW"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XW"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XU","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XU"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XU"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.814977645874023}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XZ","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"XZ"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XZ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.090515613555908}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"XY"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBK.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBK"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"XCH.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XCH"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XCT.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"XCT"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"XDA.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XDA"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"XEC.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC.1"},"qc.overallScore":{"value":29.34},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XEC"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"qc.overallScore":{"value":34.028},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XCF"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XCF.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDP"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDP.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDP.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDP.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDR"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.1","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDR.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.1"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDR.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.2","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDR.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBL.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBL.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"placement_prior":{"value":-5.099145412445068}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"XDQ"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.099145412445068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"placement_prior":{"value":-4.498189449310303}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDQ.2"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"XDQ.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"placement_prior":{"value":-4.299689292907715}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"XDQ.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.299689292907715}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"XDQ.1.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ.2"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBJ.4"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBJ.3"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"internal_63f4","node_attrs":{"div":37,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBJ.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBJ.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBJ.1.1"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"XDD"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDD.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDD.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"XDD.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDD.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDD.1.1.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-4.73468542098999}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.5","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.5"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"XDK.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDK.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDK.4.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}},{"name":"XDK.4","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDK.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"XDK.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":61,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.1.1"},"ace2_binding":{"value":"1.0469899999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"NODE_0000033","node_attrs":{"div":62,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDK.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}},{"name":"XDK.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDK.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.10"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.3351006507873535}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.4"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.3"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.6"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.5"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.9","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.9"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBF.1.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}},{"name":"XBF.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.7"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBF.7.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBF.8.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}},{"name":"XBF.8","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBF.8"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E154-","S155-","F157S","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E154-, S155-, F157S, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XAY"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":54,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XAY.3"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.390021324157715}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.967257976531982}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XAY.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.967257976531982}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":58,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XAY.2.3"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.997220993041992}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":59,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XAY.2.1"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XAY.2.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.697917938232422}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":61,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XAY.1"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.2"},"ace2_binding":{"value":"0.6144499999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":63,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1.2"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000046","node_attrs":{"div":64,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XAY.1.1.3"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":65,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GL.3"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XAY.1.1.1"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-6.127554893493652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":66,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"placement_prior":{"value":-5.682618141174316}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.2","node_attrs":{"div":72,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GL.2"},"ace2_binding":{"value":"0.72587"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}},{"name":"GL.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GL.1"},"ace2_binding":{"value":"0.6888599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752889267417711"},"placement_prior":{"value":-4.494447231292725}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"XDV"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDV.1.10"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.10"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1.11"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.4","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"XDV.1.5"},"ace2_binding":{"value":"0.14808999999999992"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5359962252743784"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"XDV.1.8"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"XDV.1.2.1"},"ace2_binding":{"value":"0.26874999999999993"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2.1"},"qc.overallScore":{"value":6.25},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.8051577060608006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}}]},{"name":"NODE_0000052","node_attrs":{"div":61,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.7"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"XDV.1.7.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7.1"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000053","node_attrs":{"div":60,"clade_nextstrain":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"XDV.1.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"XDV.1.9.1"},"ace2_binding":{"value":"0.20783000000000001"},"clade_display":{"value":"24D (XDV.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5422010449483097"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":69,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E154-","S155-","F157S","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E154-, S155-, F157S, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"XBC"},"ace2_binding":{"value":"0.6871599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-09-24"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":69,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":74,"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.2"},"ace2_binding":{"value":"0.6871599999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.2.1"},"ace2_binding":{"value":"0.58838"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.44507236664312827"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000057","node_attrs":{"div":71,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":71,"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"XBC.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":72,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.5","node_attrs":{"div":76,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.1.5"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"XBC.1.4","node_attrs":{"div":77,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XBC.1.4"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"NODE_0000059","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.1.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"XBC.1.2.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":79,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"XBC.1.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":80,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.1.1"},"ace2_binding":{"value":"0.11213999999999996"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.48837241784414276"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.1.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":77,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"XBC.1.7.1"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7","node_attrs":{"div":77,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.7"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.2","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.7.2"},"ace2_binding":{"value":"0.5473299999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":73,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"XBC.1.3"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":79,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":79,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"XBC.1.3.1"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":80,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"KD.2"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.1","node_attrs":{"div":81,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"KD.1"},"ace2_binding":{"value":"0.7857899999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.4","node_attrs":{"div":84,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"KD.4"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}},{"name":"KD.3","node_attrs":{"div":82,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"KD.3"},"ace2_binding":{"value":"0.79272"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":85,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":85,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.6"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.2"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":88,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.4"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":89,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBC.1.6.5"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":86,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":89,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GT.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":86,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":88,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":90,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"JT.1"},"ace2_binding":{"value":"0.47217000000000003"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7550301657183831"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":88,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBC.1.6.6"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":87,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":87,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBC.1.6.3"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":90,"clade_nextstrain":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_display":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":93,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HW.1.1"},"ace2_binding":{"value":"0.63844"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.7420325830319254"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HW.1"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.2","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HW.1.2"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1.3","node_attrs":{"div":91,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HW.1.3"},"ace2_binding":{"value":"0.6392699999999999"},"clade_display":{"value":"recombinant"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"XBB"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.365608215332031}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.223729610443115}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.390652656555176}},"branch_attrs":{"mutations":{"nuc":["C14178T","-29759G"]}}},{"name":"XBB.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T14574C","-29759G"]}}},{"name":"XBB.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.9"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"placement_prior":{"value":-4.663937568664551}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.4"},"ace2_binding":{"value":"0.3064099999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"placement_prior":{"value":-4.663937568664551}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.4.1"},"ace2_binding":{"value":"0.26627999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0810114368008295"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"internal_ORF1a_G82D","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-4.418038845062256}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.6.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.6.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C14178T","C14362T","C22792A","C25539T"]}}},{"name":"NODE_0000077","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.8.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.8.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"placement_prior":{"value":-4.484416961669922}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.484416961669922}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.3.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.830880165100098}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.3.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.3.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-4.122152805328369}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.122152805328369}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.12"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.178323268890381}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.636689186096191}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.256889343261719}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.545111656188965}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"internal_619ad3bd","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"placement_prior":{"value":-5.454404830932617}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.11"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.454404830932617}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.11.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000082","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.7.1"},"ace2_binding":{"value":"1.65097"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-4.833042144775391}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.10"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000084","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.2.6.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.6.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GH.1"},"ace2_binding":{"value":"0.35217"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.2.6.1"},"ace2_binding":{"value":"0.35217"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":34,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.2.3.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.14"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.20"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.2.3.18"},"ace2_binding":{"value":"0.0750199999999999"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2567103717994188"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.21"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.22"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.5"},"ace2_binding":{"value":"0.84876"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-12"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.456076622009277}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.9"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GZ.1"},"ace2_binding":{"value":"0.92117"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.4"},"ace2_binding":{"value":"0.92117"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JA.1"},"ace2_binding":{"value":"0.13359999999999994"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.13"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JU.1"},"ace2_binding":{"value":"0.84789"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0527558336884004"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.12"},"ace2_binding":{"value":"0.90647"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-4.90196418762207}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.16"},"ace2_binding":{"value":"0.84876"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.17"},"ace2_binding":{"value":"0.89912"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0248043607383275"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JS.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"JS.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JS.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.15"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.19"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JY.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JY.1.1"},"ace2_binding":{"value":"0.88039"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}},{"name":"JY.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JY.1"},"ace2_binding":{"value":"0.88039"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.972652912139893}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.6"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GM.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GM.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GM.3.1"},"ace2_binding":{"value":"0.89932"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736186906064397"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.8"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"HG.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HG.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HG.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}},{"name":"HG.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HG.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.11"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GS.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.295290470123291}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GS.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000102","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GS.2"},"ace2_binding":{"value":"0.7709600000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0079043361863298"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GS.8"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-4.607783794403076}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GS.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.7"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GS.7"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GS.7.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GS.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GS.4"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GS.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GS.4.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}},{"name":"GS.4.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GS.4.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.2.3.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.6","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HH.5"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.8.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.8","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.8"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000111","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HH.1.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"HH.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HH.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HH.2.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.2.3.10"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GE.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":37,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GE.1.3"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GE.1.4"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GE.1.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"placement_prior":{"value":-4.00916051864624}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GE.1.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GE.1.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GE.1.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GE.1.2.2"},"ace2_binding":{"value":"0.70075"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.986824739722089"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":45,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GE.1.2.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":49,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KT.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":50,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"KT.1.1"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KT.1.2"},"ace2_binding":{"value":"0.95933"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":35,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GJ.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.2.3.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":36,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"placement_prior":{"value":-4.2036452293396}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.6"},"ace2_binding":{"value":"0.13359999999999994"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GJ.7"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.5"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GJ.5.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GJ.5"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GJ.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-02"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GJ.1.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GJ.1.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.8"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.7"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GJ.1.2.4"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GJ.1.2.3"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GJ.1.2.5"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.6"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.4524970054626465}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GJ.1.2.1"},"ace2_binding":{"value":"0.89912"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0248043607383275"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JE.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":47,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JE.1.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":48,"clade_nextstrain":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JE.1.1.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KH.1"},"ace2_binding":{"value":"0.75251"},"clade_display":{"value":"23E (XBB.2.3)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_XBB1_out","node_attrs":{"div":27,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.063088417053223}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.063088417053223}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.10"},"ace2_binding":{"value":"1.13558"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.3"},"ace2_binding":{"value":"0.49564"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-5.383153915405273}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-5.09111213684082}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.33"},"ace2_binding":{"value":"1.0545"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.49"},"ace2_binding":{"value":"0.89405"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.542330265045166}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.20"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.48"},"ace2_binding":{"value":"-0.9722600000000003"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-7.0218706130981445}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"XBB.1.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.19.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GW.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GW.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GW.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.19.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":41,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GW.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GW.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000141","node_attrs":{"div":46,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GW.5"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.2"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":48,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.3"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GW.5.3.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":48,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GW.5.1"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":54,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GW.5.1.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KE.2"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KE.3"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}},{"name":"KE.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"KE.1"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":28,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.1298351287841797}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.21"},"ace2_binding":{"value":"0.86729"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.27"},"ace2_binding":{"value":"0.2602599999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.29"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.36"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.40"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.6"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.8"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.393089294433594}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"XBB.1.7","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.7"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.919648170471191}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"internal_32defdcb","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"placement_prior":{"value":-4.727026462554932}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.13"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.727026462554932}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.13.1"},"ace2_binding":{"value":"0.18493000000000007"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000147","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XBB.1.12.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}},{"name":"XBB.1.12","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.12"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000148","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.14"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.14.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.15"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.15.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.37.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.37"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"placement_prior":{"value":-4.930384159088135}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.38"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.930384159088135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.38.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.0709428787231445}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"placement_prior":{"value":-5.253978729248047}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.43"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.253978729248047}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.43.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"placement_prior":{"value":-5.3449578285217285}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.44"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3449578285217285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.44.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"placement_prior":{"value":-5.039181232452393}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.45"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.039181232452393}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.45.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000155","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.31"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.31.1"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.31.2"},"ace2_binding":{"value":"1.54089"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.4.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-25"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.4","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.34.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.34","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HB.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.34.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.9296627044677734}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.30"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.751845836639404}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.39"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.072850704193115}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"placement_prior":{"value":-5.253643989562988}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.32"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.253643989562988}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.32.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"placement_prior":{"value":-4.567584037780762}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.28"},"ace2_binding":{"value":"1.05231"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"placement_prior":{"value":-4.83050012588501}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FW.2"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.068525314331055}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"FW.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FW.3"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.28.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-4.83050012588501}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"placement_prior":{"value":-5.344550132751465}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FW.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF6:3-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.344550132751465}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FW.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FW.1.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"frameShifts":{"value":"ORF6:3-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FW.1.1.1"},"ace2_binding":{"value":"1.13254"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"1.2584103390429446"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.11"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FP.4","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FP.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.11.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FP.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":38,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FP.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FP.2.1.1"},"ace2_binding":{"value":"0.7388600000000002"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FP.2.1.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"NODE_0000170","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-3.9296627044677734}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.1"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.35"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.46"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.47"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.47.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.24.1"},"ace2_binding":{"value":"1.05408"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000173","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.24.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"XBB.1.24.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.24.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.18"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"placement_prior":{"value":-4.357847690582275}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.18.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.357847690582275}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FE.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FE.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FE.1.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FE.1.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FE.1.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"internal_8af9e862","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FE.1.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000179","node_attrs":{"div":40,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HE.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HE.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"placement_prior":{"value":-6.729740619659424}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.41.2"},"ace2_binding":{"value":"1.6066099999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1099290580037755"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"XBB.1.41","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41"},"ace2_binding":{"value":"1.65784"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-6.729740619659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41.3"},"ace2_binding":{"value":"1.65784"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"JW.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JW.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JW.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JW.1.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-5.805068492889404}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.41.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.805068492889404}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-5.6849284172058105}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.6"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":40,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"JC.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JC.5"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JC.5.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.2"},"ace2_binding":{"value":"1.43418"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.3"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.1"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JC.4"},"ace2_binding":{"value":"1.51123"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.17"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.17.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"NODE_0000188","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GA.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.17.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GA.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.10"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"GA.10.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-03"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.10","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.6.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}},{"name":"GA.6","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.8.1"},"ace2_binding":{"value":"0.96117"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GA.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000194","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.2.1.1"},"ace2_binding":{"value":"0.80721"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000195","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.7"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GA.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.7.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}},{"name":"GA.7.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.7.1"},"ace2_binding":{"value":"0.90647"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}}]},{"name":"NODE_0000196","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GA.4"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.4.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GA.4.3"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":46,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"GA.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GA.4.1"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"GA.4.1.1"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"GA.4.1.3"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"GA.4.1.2"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-3.7878472805023193}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7878472805023193}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.110"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.110"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.23"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.43"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.45"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.58"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.57"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.87"},"ace2_binding":{"value":"0.93509"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.87"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"placement_prior":{"value":-3.8739588260650635}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GF.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8739588260650635}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":31,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-2.2756154537200928}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.10"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.101"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.101"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.104"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.104"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.082764148712158}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.105"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.105"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.5.108"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.108"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.109"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.109"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.960801124572754}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.645129442214966}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.18"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7350516319274902}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.002415180206299}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.8490023612976074}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.29"},"ace2_binding":{"value":"0.41404999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.31"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8875601291656494}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.282256126403809}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.35"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.062932968139648}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.33"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6394481658935547}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.36"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.254404544830322}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.40"},"ace2_binding":{"value":"0.95377"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.19888973236084}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.51"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.52"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.847869634628296}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.54"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.59"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.106851100921631}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.62"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.189829349517822}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.63"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.750345468521118}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.66"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.64"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.1698079109191895}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.67"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7678160667419434}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.69"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.2668538093566895}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.75"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.79"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.65611457824707}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.80"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.80"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.274653434753418}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.85"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.85"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.9143218994140625}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.82"},"ace2_binding":{"value":"0.91194"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.82"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.97"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.97"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.98"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.98"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.99"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.99"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"NODE_0000202","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"placement_prior":{"value":-4.359124660491943}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.174046039581299}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.359124660491943}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EM.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"placement_prior":{"value":-4.762969017028809}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GG.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.809885501861572}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.38"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.762969017028809}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"placement_prior":{"value":-3.9225881099700928}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HJ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9225881099700928}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"placement_prior":{"value":-4.109567165374756}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HM.1"},"ace2_binding":{"value":"0.29094"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1023732112409157"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.30"},"ace2_binding":{"value":"0.41123000000000004"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-4.109567165374756}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HQ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.92"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"placement_prior":{"value":-4.495350360870361}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HY.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.282760143280029}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.100"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.495350360870361}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"placement_prior":{"value":-3.7284648418426514}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JK.1"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-4.850557327270508}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.3"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-3.7284648418426514}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JZ.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.107"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KM.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-31"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.50"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.71"},"ace2_binding":{"value":"0.48403999999999986"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"placement_prior":{"value":-4.277385711669922}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GC.2"},"ace2_binding":{"value":"0.9061"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.03073601411565"},"placement_prior":{"value":-4.989252090454102}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GC.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.21"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.277385711669922}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"placement_prior":{"value":-4.297374248504639}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.86"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.297374248504639}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"placement_prior":{"value":-5.091251373291016}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HA.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.850919246673584}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HA.2"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.93"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":41,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HD.1"},"ace2_binding":{"value":"0.7416800000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"HD.1.1"},"ace2_binding":{"value":"0.73864"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"placement_prior":{"value":-4.26259183883667}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.55"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.26259183883667}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HP.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HP.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HP.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.95"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HS.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HS.1.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.999212265014648}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}},{"name":"HS.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HS.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"placement_prior":{"value":-4.020705223083496}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FG.1"},"ace2_binding":{"value":"1.1186099999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FG.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.511922359466553}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"FG.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FG.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.16"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.020705223083496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"placement_prior":{"value":-4.372507572174072}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FZ.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.47"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.372507572174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FZ.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FZ.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FZ.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HZ.3"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.68"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HZ.2"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}},{"name":"HZ.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HZ.1"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HC.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.44"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":39,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.4","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"HC.4"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}},{"name":"HC.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HC.3"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HC.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"placement_prior":{"value":-3.5768113136291504}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"EK.1"},"ace2_binding":{"value":"0.9873000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0346353162114479"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EK.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.174570083618164}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EK.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.5768113136291504}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EK.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EK.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EK.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26"},"placement_prior":{"value":-4.580837726593018}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.26"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.580837726593018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EU.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"EU.1"},"ace2_binding":{"value":"0.9577000000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":36,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"EU.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EU.1.1"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EU.1.1.2"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"EU.1.1.1"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EU.1.1.3"},"ace2_binding":{"value":"0.5237400000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"placement_prior":{"value":-4.349014759063721}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"GN.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.842705726623535}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GN.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GN.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.73"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.349014759063721}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":36,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GN.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"GN.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GN.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GN.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GN.1.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GN.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"GN.1.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GN.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.102"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"JD.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JD.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JD.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":42,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JD.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JD.1.2.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JD.1.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-4.970314979553223}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JD.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.970314979553223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":42,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":44,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.8"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KK.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"KK.2"},"ace2_binding":{"value":"-1.20635"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2868306565498102"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000244","node_attrs":{"div":43,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"placement_prior":{"value":-3.328376531600952}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.2"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JD.1.1.4"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.5"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JD.1.1.3"},"ace2_binding":{"value":"-1.1261900000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3046787170970133"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.6"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"JD.1.1.7"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":41,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.11"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.7","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.5.70"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-05-22"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":43,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GK.5.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.5.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.8.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.4"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.3.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.3.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":42,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.12"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":44,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GK.2"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.2"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.3"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.2.4"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.2.1"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.2.1.1"},"ace2_binding":{"value":"-0.89509"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":44,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.1.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.4"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.7","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GK.1.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}},{"name":"GK.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GK.1.11"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.11.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"GK.1.2.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GK.1.6.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GK.1.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.8"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"GK.1.8.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000259","node_attrs":{"div":49,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"GK.1.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":51,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GK.1.10.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":52,"clade_nextstrain":{"value":"23G"},"Nextclade_pango":{"value":"KN.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"KN.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KN.1.1"},"ace2_binding":{"value":"-1.1446400000000003"},"clade_display":{"value":"23G (XBB.1.5.70)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3541583181563797"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":32,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"placement_prior":{"value":-2.4133341312408447}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.106"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.106"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.20"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.677788496017456}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.25"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.187700271606445}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.27"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.515899658203125}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.32"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.674118757247925}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.37"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.098421096801758}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.56"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.201076984405518}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.61"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.265189170837402}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.60"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.624792575836182}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.65"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8305318355560303}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.72"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.74"},"ace2_binding":{"value":"0.9630099999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0169257119491577"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.76"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.102489471435547}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.78"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.449106693267822}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.83"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.83"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.545154094696045}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.84"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.84"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.255393981933594}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.81"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.81"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.62812614440918}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.89"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.89"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.88"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.88"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.298462867736816}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.5.90"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.90"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.91"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.91"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.191501617431641}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.94"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.94"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.96"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.96"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.111917018890381}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000263","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FH.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.17"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GR.1"},"ace2_binding":{"value":"0.83085"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.42"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GU.1"},"ace2_binding":{"value":"0.83156"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9838451476656441"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.41"},"ace2_binding":{"value":"0.93473"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"GV.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.13517951965332}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.48"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"KA.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.103"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"GB.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"GB.1"},"ace2_binding":{"value":"0.9350799999999999"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.46"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.77"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":43,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"HR.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HR.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HR.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"placement_prior":{"value":-3.817796230316162}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HT.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"HT.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.310756206512451}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.49"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.817796230316162}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":37,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.5.53"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JB.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"JB.1"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JB.1.1"},"ace2_binding":{"value":"1.74111"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]},{"name":"NODE_0000274","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"JB.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"JB.2"},"ace2_binding":{"value":"1.5945"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"JB.2.1"},"ace2_binding":{"value":"1.5945"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FT.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.5.39"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FT.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FT.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FT.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FT.3.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FT.3.1.1"},"ace2_binding":{"value":"0.74638"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0924169334128189"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":33,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.3"},"ace2_binding":{"value":"0.89299"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"XBB.1.5.15"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FD.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FD.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FD.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"FD.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}},{"name":"FD.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FD.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}}]},{"name":"NODE_0000283","node_attrs":{"div":34,"clade_nextstrain":{"value":"23A"},"Nextclade_pango":{"value":"FD.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FD.5.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}},{"name":"FD.5","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FD.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23A (XBB.1.5)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.837927341461182}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.25"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.560931205749512}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.26"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"placement_prior":{"value":-4.2507476806640625}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"XBB.1.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.2507476806640625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.22.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"HU.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.22.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"HU.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"HU.1"},"ace2_binding":{"value":"0.86018"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.950188045949472"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HU.1.1"},"ace2_binding":{"value":"0.67693"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9788766097021935"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":32,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"XBB.1.22.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}},{"name":"FY.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"placement_prior":{"value":-5.388861656188965}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.6.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.6.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.8"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.8.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.8.1.1"},"ace2_binding":{"value":"0.8926499999999999"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}},{"name":"FY.8.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.8.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.3"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.86080265045166}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.3.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.3.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.4"},"ace2_binding":{"value":"0.80106"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.2"},"ace2_binding":{"value":"0.80106"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"NODE_0000297","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"placement_prior":{"value":-5.027553558349609}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.4.1"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-5.027553558349609}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.1.1"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.4.1.2"},"ace2_binding":{"value":"0.74983"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-09-06"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"placement_prior":{"value":-5.234410285949707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FY.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.234410285949707}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FY.5.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.5.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"FY.5.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.5.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.5"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.5.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.5.5.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"placement_prior":{"value":-5.343003273010254}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.343003273010254}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FY.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FY.1.4.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}},{"name":"FY.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FY.1.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_6436aedc","node_attrs":{"div":36,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FY.1.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"FY.1.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FY.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000305","node_attrs":{"div":37,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FY.1.2.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FY.1.2.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":39,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"placement_prior":{"value":-2.9962706565856934}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16.10","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.10"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.11"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.181058883666992}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-2.9962706565856934}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.12"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.213220119476318}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.14"},"ace2_binding":{"value":"0.7388600000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.16"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.17"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.129993438720703}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.18"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.19"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.20"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.21"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.22"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.469313621520996}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XBB.1.16.24"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.23"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.350697994232178}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.25"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"XBB.1.16.27"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.26"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.198868751525879}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"XBB.1.16.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.220455169677734}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.8"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.9"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.036108016967773}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000307","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KJ.1"},"ace2_binding":{"value":"0.64385"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.32"},"ace2_binding":{"value":"0.64385"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JM.2"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JM.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.15"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":40,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"placement_prior":{"value":-4.32681131362915}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.29"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.30"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.16.31"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.13"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000311","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"HF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HF.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HF.1.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.093987464904785}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"HF.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.6"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"placement_prior":{"value":-3.1121838092803955}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JF.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JF.3"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JF.4"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"JF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"JF.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{}}},{"name":"internal_398cc75a","node_attrs":{"div":47,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"JF.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JF.1.1.2"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JF.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}},{"name":"JF.1.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"JF.1.1.1"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"placement_prior":{"value":-3.4112071990966797}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.4"},"ace2_binding":{"value":"2.14642"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FU.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"XBB.1.16.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.4112071990966797}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FU.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.3"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}},{"name":"FU.3.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.3.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}}]},{"name":"NODE_0000319","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FU.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":44,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"FU.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FU.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FU.1.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":41,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.4","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.4"},"ace2_binding":{"value":"0.8164899999999998"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.5","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GY.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.6"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.7","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.8"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.9"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"XBB.1.16.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GY.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GY.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"GY.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":46,"clade_nextstrain":{"value":"23B"},"Nextclade_pango":{"value":"GY.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"GY.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"GY.1.1.1"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_display":{"value":"23B (XBB.1.16)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"placement_prior":{"value":-4.938050270080566}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.23"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":33,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.138284683227539}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000327","node_attrs":{"div":35,"clade_nextstrain":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"HL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"HL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.42.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"22F (XBB)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"placement_prior":{"value":-4.201934337615967}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.201934337615967}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"XBB.1.9.5"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"XBB.1.9.6"},"ace2_binding":{"value":"1.13558"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.4"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.9.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000329","node_attrs":{"div":33,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GD.2"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GD.1"},"ace2_binding":{"value":"1.6875"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"placement_prior":{"value":-4.331242084503174}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"GD.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"XBB.1.9.3"},"ace2_binding":{"value":"0.40686999999999995"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":34,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"placement_prior":{"value":-3.3911843299865723}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.064053058624268}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.234268665313721}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.16"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.22"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.301856517791748}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.25"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.497269630432129}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.27","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.27"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.29","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.29"},"ace2_binding":{"value":"0.7904599999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6592278480529785}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.28","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.28"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.34","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.34"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FL.36"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.37"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.926265716552734}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.40"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.2174906730651855}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.9","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"FL.7","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.511373996734619}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.6","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.3911843299865723}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000331","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.19"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.19"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.19.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.24"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.24"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"FL.24.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.24.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.26"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.26"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.26.1"},"ace2_binding":{"value":"1.0848"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9957660361777405"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.30"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.30"},"ace2_binding":{"value":"0.90046"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.30.1"},"ace2_binding":{"value":"0.90046"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.31"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.31"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FL.31.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.33"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.33"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.33.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.513132572174072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000337","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.32"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.32"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.32.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.35"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.35"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.35.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.911900520324707}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.39"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.39"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.39.1"},"ace2_binding":{"value":"0.81109"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.5.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.17"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.17.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.17"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.17.2"},"ace2_binding":{"value":"0.97144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.18"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.18"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.18.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.18.1.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.20"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.20.1"},"ace2_binding":{"value":"0.5920999999999998"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.20.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.20","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.20"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000345","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.21"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.21.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}},{"name":"FL.21.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.21.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.21"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.3","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.10.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"FL.10.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.10.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"FL.10.2"},"ace2_binding":{"value":"0.98073"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1216394663867173"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}}]},{"name":"NODE_0000347","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.23"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.23"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.23.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.23.2"},"ace2_binding":{"value":"0.96117"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.23.2.1"},"ace2_binding":{"value":"0.8835"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.3.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.2","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.3.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.1"},"ace2_binding":{"value":"0.47537999999999986"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.13.2"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.13.2.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":35},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.13.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.3.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.13.3.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.13.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FL.13.4.1"},"ace2_binding":{"value":"0.07635999999999983"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"placement_prior":{"value":-4.673274040222168}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.38"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_24b5ee08","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.15.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000358","node_attrs":{"div":41,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.15.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.15.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000359","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FL.15.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":48,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"FL.15.1.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000361","node_attrs":{"div":49,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KF.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"KF.2"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]}]},{"name":"internal_7f0cfce5","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"placement_prior":{"value":-3.8401038646698}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8401038646698}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.6712799072265625}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FL.2.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.2.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.2.3.1"},"ace2_binding":{"value":"1.00936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.2.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.2.7.1"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000366","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.10"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.4.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.8"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.455664157867432}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-3.775200128555298}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.4.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.4"},"ace2_binding":{"value":"0.93509"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.7"},"ace2_binding":{"value":"0.97144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.9"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.4.1"},"ace2_binding":{"value":"0.48144"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0186868047371063"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.1.1"},"ace2_binding":{"value":"0.3348299999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000369","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.4.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FL.4.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FL.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.3","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.7"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FL.1.8"},"ace2_binding":{"value":"0.78812"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"FL.1.4"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.6"},"ace2_binding":{"value":"0.89211"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9778643306477401"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"placement_prior":{"value":-4.54828405380249}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FL.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.54828405380249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000374","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.5.2"},"ace2_binding":{"value":"0.06800999999999986"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-23"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000375","node_attrs":{"div":47,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"KC.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"KC.1.1"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"KC.1"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000376","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FL.1.5.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.5"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.6"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000377","node_attrs":{"div":46,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HN.4"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.4.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000378","node_attrs":{"div":47,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.4.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"HN.4.1.1"},"ace2_binding":{"value":"0.0007299999999998658"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005141566416802"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000379","node_attrs":{"div":43,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"placement_prior":{"value":-3.123271942138672}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.8","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.8"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"HN.7","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HN.7"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.777099132537842}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"NODE_0000380","node_attrs":{"div":45,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.2"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HN.2.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000381","node_attrs":{"div":44,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"HN.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HN.3"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HN.3.1"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000382","node_attrs":{"div":35,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"placement_prior":{"value":-3.6187987327575684}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.11"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.13","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.13"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.14","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.14"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.12","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.12"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.7","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.7"},"ace2_binding":{"value":"1.1186099999999999"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"XBB.1.9.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.6187987327575684}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.9"},"ace2_binding":{"value":"1.20938"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.9.1"},"ace2_binding":{"value":"1.17686"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.10"},"ace2_binding":{"value":"1.17686"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.10.1"},"ace2_binding":{"value":"1.1256300000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"EG.10.1.1"},"ace2_binding":{"value":"1.1256300000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"placement_prior":{"value":-4.0006818771362305}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.6"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000387","node_attrs":{"div":39,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.6.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.6.1.1"},"ace2_binding":{"value":"0.07635999999999983"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.6.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000388","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"placement_prior":{"value":-4.091076374053955}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.091076374053955}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.2.1"},"ace2_binding":{"value":"0.041689999999999984"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.2.2"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.2.3"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.2.4"},"ace2_binding":{"value":"0.86275"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}},{"name":"EG.2.5","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.2.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EG.4.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.3","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EG.4.5"},"ace2_binding":{"value":"0.8657900000000001"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EG.4.4","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.4.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000391","node_attrs":{"div":37,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.1.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.2","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.2"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1.3"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.6","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EG.1.6"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.7","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.7"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.5","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.5"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.1.8"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"EG.1.4"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"EG.1.4.1"},"ace2_binding":{"value":"1.0124"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":40,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"placement_prior":{"value":-4.937782287597656}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"internal_cc5f07eb","node_attrs":{"div":42,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.2.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.2.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000395","node_attrs":{"div":46,"clade_nextstrain":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"EG.5.2.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EG.5.2.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23D (XBB.1.9)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000396","node_attrs":{"div":42,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"placement_prior":{"value":-3.371582269668579}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.371582269668579}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.10"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.843295574188232}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.12"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.14"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.343207836151123}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EG.5.1.13"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.16"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.17"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.615509510040283}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.19"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.18"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EG.5.1.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.7"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.310630798339844}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.9"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.4040846824646}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JJ.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.377831935882568}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.11"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JR.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JR.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000400","node_attrs":{"div":49,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JR.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"JR.1.1"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JR.1.1.1"},"ace2_binding":{"value":"-0.73257"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-29"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4312755323086508"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000401","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"placement_prior":{"value":-4.454830646514893}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.454830646514893}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000402","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"KB.4"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"KB.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"NODE_0000403","node_attrs":{"div":44,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"placement_prior":{"value":-3.3506245613098145}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.3"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.3506245613098145}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JG.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"JG.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"JG.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000404","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"JG.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JG.3.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"JG.3.2"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"placement_prior":{"value":-3.8458521366119385}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.4","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3.4"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"placement_prior":{"value":-5.12369441986084}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"JG.3.3","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JG.3.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}}]}]},{"name":"NODE_0000405","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"placement_prior":{"value":-3.7382917404174805}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"EG.5.1.6"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7382917404174805}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000406","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"placement_prior":{"value":-3.067814826965332}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.1"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-3.067814826965332}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.11"},"ace2_binding":{"value":"0.0887599999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3341105633249508"},"placement_prior":{"value":-5.31048583984375}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.10","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HV.1.10"},"ace2_binding":{"value":"-0.025979999999999802"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.3","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.3"},"ace2_binding":{"value":"0.21974"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005451981781486"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.5"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.4","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.4"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.8","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.8"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.9"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.7","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HV.1.7"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.1"},"ace2_binding":{"value":"0.048559999999999943"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.2"},"ace2_binding":{"value":"-0.38161000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3552393372267753"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000408","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HV.1.6"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":52,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"HV.1.6.1"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000410","node_attrs":{"div":53,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"KL.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1.1","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"KL.1.1"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"KL.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"KL.1"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000411","node_attrs":{"div":45,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"EG.5.1.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.12"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.19","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.19"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.508697986602783}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.18","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.18"},"ace2_binding":{"value":"0.14733999999999992"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.17","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.17"},"ace2_binding":{"value":"0.13706999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1972306507819483"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.21","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.21"},"ace2_binding":{"value":"0.1481699999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.205901853206978"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HK.22"},"ace2_binding":{"value":"-0.49366"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.310148541751831"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"HK.25"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-27"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HK.28"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.29"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.32","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.32"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.30","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"HK.30"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.31","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.31"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.4","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.4"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.5"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.7"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"HK.1.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}},{"name":"HK.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.1"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.11"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}},{"name":"HK.11.1","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.11.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.2"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.20"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.20"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.20.1"},"ace2_binding":{"value":"-0.6088199999999999"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2183176254438959"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.24"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.24"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.24.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.23"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.23"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000418","node_attrs":{"div":51,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.23.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"HK.23.1.1"},"ace2_binding":{"value":"-0.48614000000000007"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3534097328298118"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.27"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.27"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000420","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.27.1.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HK.27.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.27.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.6"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.26"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.26.1"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.919094562530518}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"HK.26","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.26"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.33"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.34"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.34"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.34.1"},"ace2_binding":{"value":"0.18525999999999987"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.13"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.13.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.202107906341553}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.13"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000426","node_attrs":{"div":50,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.13.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"HK.13.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.15","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.15"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.14","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.14"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.16"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-5.089319229125977}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.9"},"ace2_binding":{"value":"0.18829999999999997"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"clade_nextstrain":{"value":"23F"},"Nextclade_pango":{"value":"HK.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.8.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23F (EG.5.1)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"clade_nextstrain":{"value":"23H"},"Nextclade_pango":{"value":"HK.3"},"clade_display":{"value":"23H (HK.3)"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"HK.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.12"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.13"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.741406440734863}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.11","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.11"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.10","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.10"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.14","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.14"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.4","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.4"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.3","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.3"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.6"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.5","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.5"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.7","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.7"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"HK.3.8"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"HK.3.9","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.9"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"clade_nextstrain":{"value":"23H"},"Nextclade_pango":{"value":"HK.3.2"},"clade_display":{"value":"23H (HK.3)"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"HK.3.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"HK.3.2.2"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"HK.3.2.1"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_display":{"value":"23H (HK.3)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0804131031036377}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.15","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.15"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.830561637878418}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.16","node_attrs":{"div":1,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.16"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.231330394744873}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.19","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.19"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.5045647621154785}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"placement_prior":{"value":-4.282581329345703}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":1,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2.87"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.282581329345703}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"BA.2.87.1"},"ace2_binding":{"value":"0.8217399999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":41},"immune_escape":{"value":"0.6657453429914796"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-4.726780414581299}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":44},"Nextclade_pango":{"value":"BA.3"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-12-14"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-3.8444693088531494}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":46},"Nextclade_pango":{"value":"BA.1"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"placement_prior":{"value":-0.807468593120575}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"placement_prior":{"value":-2.9267306327819824}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":18},"Nextclade_pango":{"value":"B.1.1.7"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"placement_prior":{"value":-1.1350728273391724}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000436","node_attrs":{"div":63,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"placement_prior":{"value":-1.8536394834518433}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":4},"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-1.8536394834518433}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000437","node_attrs":{"div":66,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"placement_prior":{"value":-1.5038626194000244}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":2},"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-1.5038626194000244}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":84,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":19},"Nextclade_pango":{"value":"B.1.617.2"},"clade_display":{"value":"outgroup"},"designation_date":{"value":"2021-04-21"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.617.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":2},"placement_prior":{"value":-0.5609392523765564}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034G","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E154-","S155-","F157S","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E154-, S155-, F157S, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E154-, S155-, F157S, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"clade_nextstrain":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"placement_prior":{"value":-3.074878454208374}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"A","node_attrs":{"div":73,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":1},"Nextclade_pango":{"value":"A"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"A"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-2.9458060264587402}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}},{"name":"B","node_attrs":{"div":70,"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":0},"Nextclade_pango":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_membership":{"value":"outgroup"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":0},"placement_prior":{"value":-3.074878454208374}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000439","node_attrs":{"div":1,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.4854967594146729}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.957334518432617}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.11"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.9937210083007812}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.18"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.061908483505249}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.20"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.934056282043457}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.24"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.01261797446067892"},"placement_prior":{"value":-3.048593759536743}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.26"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.5785772800445557}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.27","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.27"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9512088298797607}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.28","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.28"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.956737041473389}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.29"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.246607542037964}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.30","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.30"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.18751859664917}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.32"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.726752996444702}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.4","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.4"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7649905681610107}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.39","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.39"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.42","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.42"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.43"},"ace2_binding":{"value":"0.11284999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"placement_prior":{"value":-4.410691261291504}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.41","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.41"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.730849266052246}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.46"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.784368991851807}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.5","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.5907044410705566}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.48","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.48"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7901194095611572}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.50"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.213822364807129}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.55"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.216464996337891}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.54","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.54"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.137808799743652}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.59","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.59"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.600815773010254}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.58","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.58"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.060970783233643}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.60","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.60"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.61","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.61"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.497117042541504}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.62"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.002424240112305}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.65","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.65"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.866245985031128}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.63","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.63"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.172652721405029}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.64","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.64"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.522981643676758}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.70","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.70"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.473325729370117}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.2.77"},"ace2_binding":{"value":"0.9213199999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3221048136122174"},"placement_prior":{"value":-5.583920955657959}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.8"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3261396884918213}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.82","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.82"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.82"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-5.217201232910156}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BA.2.83"},"ace2_binding":{"value":"1.12534"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.83"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.22071783986880583"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.85"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.85"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.306359767913818}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000440","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"placement_prior":{"value":-3.565204381942749}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.565204381942749}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.2.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000441","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"placement_prior":{"value":-3.137417793273926}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":49},"Nextclade_pango":{"value":"BA.2.23"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.137417793273926}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.23.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"placement_prior":{"value":-3.8251442909240723}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.31"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8251442909240723}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.31.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.869025230407715}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000443","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.8954713344573975}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.33"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.087352752685547}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}},{"name":"BA.2.35","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.35"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-29"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.5710673332214355}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"placement_prior":{"value":-3.801487684249878}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.40"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.801487684249878}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.40.1"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.7480976581573486}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000445","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"placement_prior":{"value":-2.980782985687256}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.56.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.698922157287598}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}},{"name":"BA.2.56","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.56"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-2.980782985687256}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000446","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"placement_prior":{"value":-2.63692569732666}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.10"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.63692569732666}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.685930013656616}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.080471038818359}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.2.10.4"},"ace2_binding":{"value":"0.73328"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3166622371297313"},"placement_prior":{"value":-5.095425605773926}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"placement_prior":{"value":-3.47294282913208}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.10.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.47294282913208}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BJ.1"},"ace2_binding":{"value":"0.09519000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.6181860283242497"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000448","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.908718228340149}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.14"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.6936566829681396}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.22"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.2798104286193848}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.34"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.117501735687256}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.36"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.086648941040039}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.47","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.47"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.130222797393799}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.49"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8066632747650146}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.52","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.52"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8890018463134766}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.51","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.51"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.761199712753296}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.6","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.6"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.67008113861084}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.7","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3845059871673584}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.69","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.69"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.045986652374268}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.71","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.71"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7314822673797607}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.72","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.72"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7303617000579834}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.80"},"ace2_binding":{"value":"0.10838000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.80"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.31190394480802347"},"placement_prior":{"value":-5.6476006507873535}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.81"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.81"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.353763580322266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.25"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.25.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.996367931365967}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"NODE_0000450","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-1.908718228340149}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.45","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.45"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"placement_prior":{"value":-3.7347371578216553}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.53","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.53"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.7460625171661377}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.44"},"ace2_binding":{"value":"0.11284999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"placement_prior":{"value":-4.219630718231201}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"placement_prior":{"value":-3.5669286251068115}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13.1","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.13.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.0240631103515625}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}},{"name":"BA.2.13","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.13"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.5669286251068115}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000453","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"placement_prior":{"value":-2.193769931793213}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9.1","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.9.1"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.9"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.193769931793213}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.628756284713745}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.9.4"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.2406187057495117}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.9.6"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.5066680908203125}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.9.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.9.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.3531694412231445}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}}]}]},{"name":"NODE_0000454","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"placement_prior":{"value":-2.485149383544922}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.1","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.1"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.1285207271575928}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.10","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.10"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.099079132080078}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.3"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-2.485149383544922}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.12"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.11"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7979795932769775}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.13"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.348191738128662}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.14"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.958454132080078}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.15"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8729355335235596}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.18"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.462960243225098}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.17"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8992807865142822}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.19"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-4.70241117477417}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.5"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.302166938781738}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.4"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.3.7"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.2.3.8"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.9"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.8521692752838135}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.16"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BP.1"},"ace2_binding":{"value":"0.9456899999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.43687237373984505"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"placement_prior":{"value":-4.601692199707031}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.3.21"},"ace2_binding":{"value":"1.06758"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.830438613891602}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DD.1"},"ace2_binding":{"value":"0.9683399999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4733677107846063"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000457","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"placement_prior":{"value":-4.1717400550842285}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BA.2.3.22"},"ace2_binding":{"value":"0.37526000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.42289430257523936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.6"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.009570121765137}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"placement_prior":{"value":-3.9328742027282715}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.3.2"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9328742027282715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000459","node_attrs":{"div":29,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BS.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BS.1"},"ace2_binding":{"value":"0.66194"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-12"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.49181526572268314"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"BS.1.1"},"ace2_binding":{"value":"0.6589000000000002"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.6029918987948071"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"BS.1.2"},"ace2_binding":{"value":"0.66821"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"frameShifts":{"value":"ORF6:34-62"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.4975483601650658"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"internal_a315","node_attrs":{"div":26,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BA.2.3.20"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CM.10"},"ace2_binding":{"value":"0.8190299999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7593324873420084"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000461","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.4"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.4"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.4.1"},"ace2_binding":{"value":"0.91683"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7016283989012374"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.6"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.6"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.6.1"},"ace2_binding":{"value":"0.9440299999999998"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8143059671640498"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000463","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.5"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.5.1"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.5.2"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"CM.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CM.5"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.8"},"ace2_binding":{"value":"0.99403"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7255583352017505"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000465","node_attrs":{"div":30,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.8.1"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CM.8.1.2"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CM.8.1.4"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000466","node_attrs":{"div":31,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.5","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CM.8.1.5"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"CM.8.1.3","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.8.1.3"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"NODE_0000467","node_attrs":{"div":35,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CM.8.1.1"},"ace2_binding":{"value":"0.17483999999999994"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"FV.1"},"ace2_binding":{"value":"0.28625999999999996"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0761544902802131"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.12"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.11"},"ace2_binding":{"value":"0.35566999999999993"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0179803928276123"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.3"},"ace2_binding":{"value":"0.29833"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.9"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CM.2"},"ace2_binding":{"value":"1.06344"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.2.1"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000470","node_attrs":{"div":29,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.7"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.7"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000471","node_attrs":{"div":30,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"CM.7.1"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"CM.7.1.1"},"ace2_binding":{"value":"0.9729599999999999"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9785485534494837"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}},{"name":"CM.7.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CM.7.1"},"ace2_binding":{"value":"0.24425000000000008"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000472","node_attrs":{"div":2,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-2.1293535232543945}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.17"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.112788200378418}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.21"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.37"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-03"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.1010122299194336}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.57"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.166472434997559}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.66"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.675938129425049}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.68"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.9366536140441895}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.73"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.040555000305176}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.74"},"ace2_binding":{"value":"0.21698000000000003"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.33134042675697756"},"placement_prior":{"value":-3.888690233230591}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.78"},"ace2_binding":{"value":"0.10556"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.6647868156433105}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000473","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"placement_prior":{"value":-3.0962488651275635}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.67"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000474","node_attrs":{"div":6,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"placement_prior":{"value":-4.71979284286499}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79.1","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.79.1"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}},{"name":"BA.2.79","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.79"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"placement_prior":{"value":-4.71979284286499}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000475","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"placement_prior":{"value":-3.6624863147735596}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.76"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-02"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-3.6624863147735596}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000476","node_attrs":{"div":6,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.76.2"},"ace2_binding":{"value":"0.11142000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.76.1"},"ace2_binding":{"value":"0.18492"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.2640232066165751"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}}]}]},{"name":"NODE_0000477","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-3.4443867206573486}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.2.38"},"ace2_binding":{"value":"0.23107"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-05-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"placement_prior":{"value":-3.4443867206573486}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"placement_prior":{"value":-4.741133213043213}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.38.3"},"ace2_binding":{"value":"0.08445999999999997"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.07383293656037815"},"placement_prior":{"value":-4.741133213043213}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BH.1"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.370455061085298"},"placement_prior":{"value":-4.580904006958008}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"internal_ab43","node_attrs":{"div":3,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-3.989638090133667}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.38.1"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.08612585067749}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"placement_prior":{"value":-4.910482883453369}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.2.38.2"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.38.4"},"ace2_binding":{"value":"0.07569000000000004"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"placement_prior":{"value":-4.449790954589844}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"placement_prior":{"value":-3.7970614433288574}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.2.12"},"ace2_binding":{"value":"-0"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"placement_prior":{"value":-3.7970614433288574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.2.12.2"},"ace2_binding":{"value":"0.07350000000000005"},"clade_display":{"value":"21L (BA.2)"},"designation_date":{"value":"2022-06-11"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.062348652344665065"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000482","node_attrs":{"div":5,"clade_nextstrain":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"placement_prior":{"value":-3.0566976070404053}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.2.12.1"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.0566976070404053}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000483","node_attrs":{"div":7,"clade_nextstrain":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"placement_prior":{"value":-1.82924222946167}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BG.2"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-18"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.1","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BG.1"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.3","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BG.3"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.567026138305664}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.4","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BG.4"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.5","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BG.5"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-07-28"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.7","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BG.7"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.6","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BG.6"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_display":{"value":"22C (BA.2.12.1)"},"designation_date":{"value":"2022-08-01"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}}]}]}]},{"name":"NODE_0000484","node_attrs":{"div":18,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"placement_prior":{"value":-3.860531806945801}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BA.2.75"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-3.860531806945801}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.10"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.499698638916016}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BA.2.75.8"},"ace2_binding":{"value":"1.04854"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.7"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-4.541248321533203}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"placement_prior":{"value":-5.736501216888428}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.9"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.736501216888428}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"CB.1"},"ace2_binding":{"value":"0.81858"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.514633655548096}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.4"},"ace2_binding":{"value":"1.13451"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000487","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.2"},"ace2_binding":{"value":"0.7472099999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.2.1"},"ace2_binding":{"value":"0.7472099999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-3.378986358642578}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.3"},"ace2_binding":{"value":"1.24593"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5588825437629772"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000489","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BR.1"},"ace2_binding":{"value":"0.9449499999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BR.1.1"},"ace2_binding":{"value":"0.9449499999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.1.2"},"ace2_binding":{"value":"0.12575999999999996"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7451886007636047"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000490","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BR.4"},"ace2_binding":{"value":"1.10514"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5013910005227346"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000491","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BR.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BR.5"},"ace2_binding":{"value":"1.03573"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BR.5.1"},"ace2_binding":{"value":"1.03573"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.1"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.4"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000493","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"placement_prior":{"value":-4.207220554351807}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.5"},"ace2_binding":{"value":"1.16854"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000494","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BL.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.2.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000495","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BL.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BL.1.1"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.1.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.1.3"},"ace2_binding":{"value":"1.19193"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BL.1.4"},"ace2_binding":{"value":"1.3464399999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BL.1.5"},"ace2_binding":{"value":"0.56756"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6011952983295785"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BL.6"},"ace2_binding":{"value":"1.11979"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5544855553668998"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"placement_prior":{"value":-4.681202411651611}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.6"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-4.681202411651611}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"placement_prior":{"value":-4.277714252471924}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BY.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.277714252471924}},"branch_attrs":{"mutations":{}}},{"name":"internal_147e","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BY.1.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BY.1.2.1"},"ace2_binding":{"value":"0.41646999999999995"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_1967","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"placement_prior":{"value":-5.0982890129089355}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BY.1.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-5.0982890129089355}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BY.1.1.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BA.2.75.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CA.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CA.2"},"ace2_binding":{"value":"0.41646999999999995"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-4.7165374755859375}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.4","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CA.4"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.7"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.5"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CA.6"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CA.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CA.3.1"},"ace2_binding":{"value":"0.2371799999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}},{"name":"CA.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CA.3"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"placement_prior":{"value":-4.096994876861572}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.5"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.096994876861572}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.4"},"ace2_binding":{"value":"1.14197"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"placement_prior":{"value":-4.784391403198242}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.6"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.629100799560547}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.5"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-4.532908916473389}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BN.2"},"ace2_binding":{"value":"1.1724299999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.2.1"},"ace2_binding":{"value":"1.14197"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.3.1"},"ace2_binding":{"value":"1.08339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.653690335850791"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.3"},"ace2_binding":{"value":"1.11385"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5060716304521155"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000505","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.10"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.11"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.7","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.8"},"ace2_binding":{"value":"0.5340599999999999"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9193315170816834"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"internal_5f66","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.1"},"ace2_binding":{"value":"1.2021600000000001"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.1.1"},"ace2_binding":{"value":"1.2021600000000001"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000507","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000508","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.5.2"},"ace2_binding":{"value":"1.1331"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7470314258752732"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.5.1"},"ace2_binding":{"value":"1.31233"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7815531080803261"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BN.1.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.4.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.4.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"NODE_0000510","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"BN.1.4.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"BN.1.4.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}},{"name":"BN.1.4.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.4.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}}]}]},{"name":"NODE_0000511","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"placement_prior":{"value":-5.13617467880249}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.9"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-11-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.220160961151123}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000512","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.2.1"},"ace2_binding":{"value":"1.21326"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7326886306518271"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.2.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.2.8"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000513","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BN.1.2.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FR.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000514","node_attrs":{"div":31,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"FR.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FR.1.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1.3","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FR.1.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FR.1.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000515","node_attrs":{"div":35,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.4","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"FR.1.4"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}},{"name":"FR.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"FR.1.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BN.1.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-4.497981071472168}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.4"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"DS.1"},"ace2_binding":{"value":"1.16291"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0513083167390975"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"DS.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"DS.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.10"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.12","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BN.1.3.12"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.1.3.2"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.9"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.8"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EJ.1"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"EJ.2"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.3","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"EJ.3"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"placement_prior":{"value":-3.269749402999878}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"BN.1.3.11"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.13"},"ace2_binding":{"value":"1.08629"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-08-06"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.5"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-02"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.880107879638672}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.6"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BN.1.3.7"},"ace2_binding":{"value":"1.25339"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000522","node_attrs":{"div":19,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"placement_prior":{"value":-4.307699680328369}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BA.2.75.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-4.307699680328369}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.3"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.5"},"ace2_binding":{"value":"1.15852"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"placement_prior":{"value":-5.031914710998535}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"BM.6"},"ace2_binding":{"value":"1.15852"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"NODE_0000523","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.2"},"ace2_binding":{"value":"1.28689"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.2.2"},"ace2_binding":{"value":"1.26994"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5272935807019111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.2.1"},"ace2_binding":{"value":"0.81858"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.2.3"},"ace2_binding":{"value":"0.78817"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.1"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-08-30"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.1.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000527","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"BM.1.1.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"BM.1.1.5"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.992039680480957}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.1.1.1"},"ace2_binding":{"value":"0.43724"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CJ.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"internal_ed55","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.1"},"ace2_binding":{"value":"0.87567"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-14"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9457248359372292"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000531","node_attrs":{"div":28,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"CJ.1.3"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.3.1"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CJ.1.3.2"},"ace2_binding":{"value":"1.04277"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"placement_prior":{"value":-4.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000532","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000533","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.1.1.3"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CV.1"},"ace2_binding":{"value":"0.42674000000000006"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CV.2"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-06"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000534","node_attrs":{"div":27,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"BM.1.1.4"},"ace2_binding":{"value":"0.46466000000000013"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000535","node_attrs":{"div":29,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EP.2"},"ace2_binding":{"value":"0.46466000000000013"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000536","node_attrs":{"div":35,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"EP.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"EP.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000537","node_attrs":{"div":39,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"EP.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1.1","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"EP.1.1.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}},{"name":"EP.1.1","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"EP.1.1"},"ace2_binding":{"value":"0.42369999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BM.4"},"ace2_binding":{"value":"1.17547"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"BM.4.1"},"ace2_binding":{"value":"0.35628"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"BM.4.1.1"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CH.2"},"ace2_binding":{"value":"0.4677"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000541","node_attrs":{"div":23,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"placement_prior":{"value":-5.852805137634277}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CH.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"CH.3"},"ace2_binding":{"value":"1.07323"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"CH.3.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CH.3.1"},"ace2_binding":{"value":"1.0219999999999998"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"clade_nextstrain":{"value":"22D"},"Nextclade_pango":{"value":"CH.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"CH.1"},"ace2_binding":{"value":"0.36891999999999997"},"clade_display":{"value":"22D (BA.2.75)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7685109779549473"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000544","node_attrs":{"div":25,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.27"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.7"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000545","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.18"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":29,"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":1},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.21"},"ace2_binding":{"value":"0.08511000000000003"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:59-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9441222497200389"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000546","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000547","node_attrs":{"div":31,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"GQ.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GQ.1"},"ace2_binding":{"value":"0.9334899999999999"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":37,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"GQ.1.1"},"ace2_binding":{"value":"0.9334899999999999"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000548","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-3.513967990875244}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.10"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.15"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.24"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.26"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.25"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.29"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"internal_ddb1","node_attrs":{"div":29,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"DV.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000550","node_attrs":{"div":31,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.8"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"DV.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.3.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"DV.6"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.6.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}},{"name":"DV.6.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":73},"Nextclade_pango":{"value":"DV.6.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"DV.7"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"DV.7.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000557","node_attrs":{"div":40,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"DV.7.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"DV.7.1.8"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000558","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.6"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"DV.7.1.7"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.2"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":81},"Nextclade_pango":{"value":"JV.1"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":48,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"JV.2"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000561","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.5"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"KG.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"KG.2"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000562","node_attrs":{"div":41,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.1"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"DV.7.1.4"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.3","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.3"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":80},"Nextclade_pango":{"value":"DV.7.1.9"},"ace2_binding":{"value":"-1.05117"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000563","node_attrs":{"div":26,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.28"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.32"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000564","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.13"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.14"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.9"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000565","node_attrs":{"div":27,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.11"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"GP.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"GP.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"GP.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000566","node_attrs":{"div":27,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"placement_prior":{"value":-3.320462703704834}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.16"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.20"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.23"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"CH.1.1.22"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.30"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.8"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.6"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"NODE_0000567","node_attrs":{"div":30,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":71},"Nextclade_pango":{"value":"CH.1.1.12"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FS.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000568","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":68},"Nextclade_pango":{"value":"CH.1.1.19"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":70},"Nextclade_pango":{"value":"FJ.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000569","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"CH.1.1.31"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000570","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"JP.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JP.1"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:62-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":79},"Nextclade_pango":{"value":"JP.1.1"},"ace2_binding":{"value":"1.05667"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"23C"},"frameShifts":{"value":"ORF7a:62-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":69},"Nextclade_pango":{"value":"CH.1.1.17"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000572","node_attrs":{"div":32,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":72},"Nextclade_pango":{"value":"FK.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-03-31"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2.1","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.2.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":78},"Nextclade_pango":{"value":"FK.1.2.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000574","node_attrs":{"div":33,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.4"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FK.1.4.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000576","node_attrs":{"div":37,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":74},"Nextclade_pango":{"value":"FK.1.5"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-04-13"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":77},"Nextclade_pango":{"value":"FK.1.1.1"},"ace2_binding":{"value":"0.16085999999999998"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9815994835819151"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.1.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.3"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"FK.1.3.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000579","node_attrs":{"div":43,"clade_nextstrain":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"placement_prior":{"value":-4.664889812469482}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":75},"Nextclade_pango":{"value":"FK.1.3.2"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.664889812469482}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":76},"Nextclade_pango":{"value":"JL.1"},"ace2_binding":{"value":"0.32796"},"clade_display":{"value":"23C (CH.1.1)"},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000580","node_attrs":{"div":48,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"LV.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LV.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000581","node_attrs":{"div":50,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"placement_prior":{"value":-4.55715799331665}},"branch_attrs":{"mutations":{"nuc":["C21T","T13339C"]}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-08-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.55715799331665}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"BA.2.86.4"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.5"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000582","node_attrs":{"div":52,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86.6"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"LV.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}}]},{"name":"NODE_0000583","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.7"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-06-13"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000584","node_attrs":{"div":58,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"MP.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"MP.1"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"MP.1.1"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.6738025507980547"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":82},"Nextclade_pango":{"value":"BA.2.86.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JQ.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000586","node_attrs":{"div":56,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JQ.2"},"ace2_binding":{"value":"1.15919"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-05"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000587","node_attrs":{"div":60,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JQ.2.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-20"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JQ.2.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JQ.2.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000588","node_attrs":{"div":52,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-5.804113388061523}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.4"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.519156455993652}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000589","node_attrs":{"div":53,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-3.827300786972046}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"BA.2.86.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-3.827300786972046}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.12"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.15","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.15"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.14","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.14"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.18","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.18"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.17","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.17"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.16","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.16"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.19","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.19"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.6"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.381936550140381}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.8","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.8"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.9","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.9"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.700376033782959}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.7","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.7"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"NODE_0000590","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.11"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.11"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.11.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000591","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.13"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":83},"Nextclade_pango":{"value":"JN.13"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.13.1"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000592","node_attrs":{"div":56,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","C6525T","C29171T"],"N":["H300Y"],"ORF1a":["P892S","T2087I"]},"labels":{"aa":"N: H300Y; ORF1a: P892S, T2087I"}},"children":[{"name":"JN.3.2","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.3.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.3.2.1"},"ace2_binding":{"value":"0.2850199999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]},{"name":"NODE_0000593","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.5"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.5.1"},"ace2_binding":{"value":"0.6465599999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}},{"name":"JN.5","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.5"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000594","node_attrs":{"div":55,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.3","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.3.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"JN.3.1","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.3.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}}]},{"name":"internal_59b29264","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2.1","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.1"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2","node_attrs":{"div":54,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.3","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.3"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":57,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.4"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":56,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":85},"Nextclade_pango":{"value":"JN.2.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000596","node_attrs":{"div":58,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"JN.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.2.2"},"ace2_binding":{"value":"1.04777"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.2.2.1"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.3875211680198292"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000597","node_attrs":{"div":54,"clade_nextstrain":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"placement_prior":{"value":-4.352321624755859}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":84},"Nextclade_pango":{"value":"JN.10"},"ace2_binding":{"value":"0.32843999999999995"},"clade_display":{"value":"23I (BA.2.86)"},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"placement_prior":{"value":-4.503751754760742}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000598","node_attrs":{"div":58,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-2.788231134414673}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-09-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-2.788231134414673}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.10"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.4109206199646}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.12"},"ace2_binding":{"value":"0.26806999999999986"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.2179718017578125}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.17"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.394025802612305}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.19"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.904604911804199}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.21","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.21"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.875519275665283}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.22"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.6741983890533447}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.493799686431885}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.31"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.34"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.491109848022461}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.37"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.408229351043701}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.40"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.050711631774902}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.45"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.297847270965576}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.46"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.232522487640381}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.804265260696411}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.52"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.117598056793213}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.61","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.61"},"ace2_binding":{"value":"0.93036"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.496607246855186"},"placement_prior":{"value":-4.409794807434082}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.62","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.62"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.60","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.60"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.342294692993164}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.66","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"JN.1.66"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"placement_prior":{"value":-4.108686923980713}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.2.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.971951484680176}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.108686923980713}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000600","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.33249568939209}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.20","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.20"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.33249568939209}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.250879764556885}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.23"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"placement_prior":{"value":-5.240912914276123}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"JN.1.23.1"},"ace2_binding":{"value":"2.21099"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.23"},"ace2_binding":{"value":"2.21099"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"placement_prior":{"value":-5.240912914276123}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.24"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"placement_prior":{"value":-5.013424396514893}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.24"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.013424396514893}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.24.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.24.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.323510646820068}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.32"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"placement_prior":{"value":-4.1628737449646}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.32"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.1628737449646}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.32.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.261566638946533}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.38"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"placement_prior":{"value":-4.847131252288818}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.38.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.38"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.847131252288818}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.43"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"placement_prior":{"value":-4.390970706939697}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.43"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.390970706939697}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.43.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.44"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"placement_prior":{"value":-4.742091655731201}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.44"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.742091655731201}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.44.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.850801944732666}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.54"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"placement_prior":{"value":-5.474041938781738}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.54"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.474041938781738}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.54.1"},"ace2_binding":{"value":"0.05681999999999991"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.532734695870142"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.56"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"placement_prior":{"value":-4.913116455078125}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.56"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.913116455078125}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.56.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.56.1"},"ace2_binding":{"value":"0.7602899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5395016697354735"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","-23009G","A23012-"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"placement_prior":{"value":-4.234557628631592}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.234557628631592}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.6.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.4928669929504395}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.59"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"placement_prior":{"value":-4.803600311279297}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.59.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"qc.overallScore":{"value":8.507},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}},{"name":"JN.1.59","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.59"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.803600311279297}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000611","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.63"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"placement_prior":{"value":-5.165487766265869}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.63"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.165487766265869}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.63.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.744463920593262}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"placement_prior":{"value":-6.049203395843506}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.25"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.049203395843506}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"placement_prior":{"value":-6.251752853393555}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.25.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.251752853393555}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LM.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"placement_prior":{"value":-4.3950371742248535}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.29"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3950371742248535}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.29.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MJ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.455280065536499}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.41"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.36"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"placement_prior":{"value":-5.332466125488281}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.36.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.063255786895752}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.36","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.36"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.332466125488281}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.47"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"placement_prior":{"value":-5.005919456481934}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.47"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.005919456481934}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.47.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.47.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.993666172027588}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"placement_prior":{"value":-5.404429912567139}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.51"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.404429912567139}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"placement_prior":{"value":-5.081503391265869}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.51.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.081503391265869}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LJ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"placement_prior":{"value":-4.514355659484863}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.55"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.514355659484863}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"placement_prior":{"value":-5.77592134475708}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.55.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.55.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"NODE_0000623","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"placement_prior":{"value":-4.698468208312988}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":59,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.67"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.698468208312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000624","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.67.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MZ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"placement_prior":{"value":-3.8991429805755615}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.39.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.853466033935547}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"JN.1.39","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.39"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.8991429805755615}},"branch_attrs":{"mutations":{}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"placement_prior":{"value":-4.175995826721191}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.39.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.563828945159912}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.39.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"placement_prior":{"value":-3.966954231262207}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.42"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.966954231262207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.42.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.303705215454102}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"placement_prior":{"value":-5.334356784820557}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.42.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.334356784820557}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"MS.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.50.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.50","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.50"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.50.2"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"ME.1"},"ace2_binding":{"value":"0.27215999999999985"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"placement_prior":{"value":-4.891570091247559}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.53"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.891570091247559}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"placement_prior":{"value":-5.835316181182861}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.53.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.835316181182861}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000633","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LN.1.1"},"ace2_binding":{"value":"0.2595099999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}},{"name":"LN.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"LN.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.65"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.65.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MF.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MF.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"placement_prior":{"value":-4.343825817108154}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.30"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.343825817108154}},"branch_attrs":{"mutations":{}}},{"name":"internal_dafb7842","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"placement_prior":{"value":-5.548880577087402}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.30.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.548880577087402}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"KU.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.693577289581299}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KU.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"placement_prior":{"value":-6.125247478485107}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KU.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KU.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.2","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KU.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.956709861755371}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.35"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.48"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000641","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.48.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"internal_137393d6","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"JN.1.48.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.48.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LD.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_566939b0","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"placement_prior":{"value":-4.3079633712768555}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.58"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3079633712768555}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.40906286239624}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"placement_prior":{"value":-5.875661849975586}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.58.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.875661849975586}},"branch_attrs":{"mutations":{}}},{"name":"LR.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LR.2"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}},{"name":"LR.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LR.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.469166278839111}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LR.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"NODE_0000646","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"placement_prior":{"value":-4.500974178314209}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.8"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.500974178314209}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.8.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"internal_edd3fce6","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"placement_prior":{"value":-4.438825607299805}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000648","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.8.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KY.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"placement_prior":{"value":-4.780362606048584}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.15"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.780362606048584}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"placement_prior":{"value":-5.424458980560303}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.15.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.424458980560303}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"placement_prior":{"value":-5.752961158752441}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LU.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LU.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2.2","node_attrs":{"div":71,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LU.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-20"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"LU.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LU.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LU.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LU.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.396687030792236}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":96},"Nextclade_pango":{"value":"LU.2.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000654","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"placement_prior":{"value":-4.625055313110352}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":86},"Nextclade_pango":{"value":"JN.1.28"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.625055313110352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000655","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.28.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"KW.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KW.1.2"},"ace2_binding":{"value":"0.9318500000000001"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3745641202332524"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000657","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KW.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000658","node_attrs":{"div":68,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KW.1.1.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LG.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"placement_prior":{"value":-4.775076866149902}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.49.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.329537868499756}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.49"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.775076866149902}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"placement_prior":{"value":-5.515918254852295}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.49.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MB.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000662","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MB.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000663","node_attrs":{"div":68,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MB.1.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MV.1"},"ace2_binding":{"value":"0.30217999999999995"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"placement_prior":{"value":-4.533131122589111}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.64"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.533131122589111}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"placement_prior":{"value":-5.344335556030273}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.64.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.344335556030273}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MD.2"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MD.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"placement_prior":{"value":-5.915351390838623}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MD.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.915351390838623}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MD.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MD.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"MD.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"MD.3.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MD.3.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.229307174682617}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.26"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.005617618560791}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000669","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-3.9326608180999756}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.14"},"ace2_binding":{"value":"1.02389"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.27"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.131450176239014}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.13"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.13.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KS.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KS.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KS.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KS.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KS.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"placement_prior":{"value":-4.098633766174316}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.57"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.57"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.57.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.1"},"ace2_binding":{"value":"1.08313"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.566636085510254}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.6906843185424805}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.1756510734558105}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.7.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.7.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000676","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.7.8"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000677","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MQ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}},{"name":"MQ.2","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MQ.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.7.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LK.1"},"ace2_binding":{"value":"1.04395"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LK.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LK.2.1"},"ace2_binding":{"value":"0.95433"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LK.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"placement_prior":{"value":-3.712366819381714}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.712366819381714}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.77679967880249}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.4"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.743769645690918}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.8"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.3"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KQ.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000682","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"placement_prior":{"value":-2.8164637088775635}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.6"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.9"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.036896228790283}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LL.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.5"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KV.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KV.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"placement_prior":{"value":-4.782667636871338}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.4.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.782667636871338}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.2"},"ace2_binding":{"value":"1.02389"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000686","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LE.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"placement_prior":{"value":-5.76973295211792}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.1.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"LE.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LE.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.76973295211792}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LE.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.145851135253906}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"NODE_0000687","node_attrs":{"div":67,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LE.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LE.1.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":73,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LE.1.3.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"placement_prior":{"value":-3.5281527042388916}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-3.5281527042388916}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.2"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.900146961212158}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.1.8"},"ace2_binding":{"value":"0.21984999999999988"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000689","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LT.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"placement_prior":{"value":-5.643091678619385}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.7"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-5.643091678619385}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LC.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"placement_prior":{"value":-4.972570896148682}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.6"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.972570896148682}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"placement_prior":{"value":-5.62172794342041}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KZ.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.62172794342041}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KZ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KZ.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000694","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"placement_prior":{"value":-3.322723865509033}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.10","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1.10"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.8855814933776855}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.391621112823486}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.4"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.850395679473877}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.1.9"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000695","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.1.5"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KR.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.5"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000696","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KR.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.4"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.4.1"},"ace2_binding":{"value":"0.2408299999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"qc.overallScore":{"value":11.111},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000697","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"KR.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KR.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KR.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.3","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"KR.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"NODE_0000698","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"placement_prior":{"value":-4.0566229820251465}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.9"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.0566229820251465}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.9.1"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.607508659362793}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"placement_prior":{"value":-5.146241664886475}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.9.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.146241664886475}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"placement_prior":{"value":-3.996425151824951}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LB.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.996425151824951}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.6","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.9","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LB.1.9"},"ace2_binding":{"value":"0.2408299999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"LB.1.8","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"NODE_0000701","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.3","node_attrs":{"div":67,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.4.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-24"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000702","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.662420749664307}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.7.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.7.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.7.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000704","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LB.1.3.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LB.1.3.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.472050666809082}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LB.1.3.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MH.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000706","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"placement_prior":{"value":-3.9273574352264404}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.16"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-3.9273574352264404}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.16.3"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.347455024719238}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"placement_prior":{"value":-5.415005207061768}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.16.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.415005207061768}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LA.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LA.2"},"ace2_binding":{"value":"0.04741999999999978"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000709","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"placement_prior":{"value":-4.693892955780029}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.16.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.026412010192871}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.16.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MT.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"NODE_0000711","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"placement_prior":{"value":-4.084128379821777}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.16.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.084128379821777}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"LF.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"LF.7"},"ace2_binding":{"value":"0.21767999999999987"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"qc.overallScore":{"value":50.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.817229820305529"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LF.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3.1.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.3.1"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000717","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"placement_prior":{"value":-5.651890277862549}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":61,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.9"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.651890277862549}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000718","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"placement_prior":{"value":-5.674976825714111}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":62,"designation_recency":{"value":"3-4 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LF.9.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.674976825714111}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000719","node_attrs":{"div":65,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.8"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LF.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000720","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LF.8.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LF.8.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}},{"name":"LF.8.1.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LF.8.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"placement_prior":{"value":-4.10247802734375}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.18"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.10247802734375}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.8"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"placement_prior":{"value":-4.954190254211426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.954190254211426}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LS.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"placement_prior":{"value":-5.688791275024414}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.688791275024414}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LH.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LH.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"placement_prior":{"value":-4.828893184661865}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.3"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.828893184661865}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MA.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"placement_prior":{"value":-7.243719577789307}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"MA.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.795672416687012}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"MA.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MA.1.1.1"},"ace2_binding":{"value":"0.3926199999999998"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"qc.overallScore":{"value":11.111},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}},{"name":"MA.1.1","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"MA.1.1"},"ace2_binding":{"value":"0.3794899999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"placement_prior":{"value":-5.446084976196289}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-5.446084976196289}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LQ.3"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"placement_prior":{"value":-5.52098274230957}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LQ.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LQ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"LQ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LQ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"NODE_0000730","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"placement_prior":{"value":-5.107730865478516}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"JN.1.18.7"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"MN.1"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":61,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"placement_prior":{"value":-5.1725053787231445}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.18.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.1725053787231445}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LY.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LY.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"NODE_0000733","node_attrs":{"div":62,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":88},"Nextclade_pango":{"value":"JN.1.18.2"},"ace2_binding":{"value":"1.14224"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":66,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LZ.1"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"LZ.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LZ.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]},{"name":"NODE_0000735","node_attrs":{"div":64,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"LZ.2"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LZ.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-08-12"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}},{"name":"LZ.2.1","node_attrs":{"div":65,"designation_recency":{"value":"2-3 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"LZ.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"clade_nextstrain":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.11"},"clade_display":{"value":"24A (JN.1)"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"placement_prior":{"value":-4.8429436683654785}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":87},"Nextclade_pango":{"value":"JN.1.11"},"ace2_binding":{"value":"1.03082"},"clade_display":{"value":"24A (JN.1)"},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"placement_prior":{"value":-4.8429436683654785}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"JN.1.11.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.5"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.6"},"ace2_binding":{"value":"0.04741999999999978"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.00890588760376}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":89},"Nextclade_pango":{"value":"KP.4"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000739","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.4.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.2"},"ace2_binding":{"value":"0.27333999999999997"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7741516492587035"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.4.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.4.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"KP.4.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.4.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"internal_7da46150","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"KP.4.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}},{"name":"KP.4.2.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.4.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]}]}]},{"name":"NODE_0000743","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.1"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-02-22"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.2"},"ace2_binding":{"value":"0.20671999999999996"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.1.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"MG.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.1.1.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"MU.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.1.1.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"LP.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"internal_bfd296bd","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LP.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000749","node_attrs":{"div":67,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.2","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.1.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LP.1.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LP.1.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]}]}]}]},{"name":"NODE_0000750","node_attrs":{"div":63,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2.10","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.10"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.11","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.11"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.616637706756592}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.12","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.12"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.14"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.19"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"qc.overallScore":{"value":1.562},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2.24"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.23"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.8"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.9"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.2.15"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.15.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.20"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.20.1","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.20.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.096656799316406}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000754","node_attrs":{"div":66,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.3"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.1"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7908990401504723"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.3.4"},"ace2_binding":{"value":"0.3312699999999998"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"NODE_0000755","node_attrs":{"div":67,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.2.3.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":96},"Nextclade_pango":{"value":"MW.1"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000756","node_attrs":{"div":64,"clade_nextstrain":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"placement_prior":{"value":-3.916172504425049}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.13"},"ace2_binding":{"value":"0.21942999999999988"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.16"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.532754898071289}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.17","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.17"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.18","node_attrs":{"div":65,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.18"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.2.2"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.22"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.4"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.5"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.321987628936768}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.6"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.2.7"},"ace2_binding":{"value":"0.3181399999999999"},"clade_display":{"value":"24B (JN.1.11.1)"},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000757","node_attrs":{"div":63,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":64,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"KP.3.4.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3.2","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.3.2"},"ace2_binding":{"value":"-1.15242"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5554650921238282"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"KP.3.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.3.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"NODE_0000760","node_attrs":{"div":68,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.3.3.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MR.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.3.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.2","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"ML.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"ML.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"ML.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.1","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.4867472648620605}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-09"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.350050449371338}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.2.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000764","node_attrs":{"div":70,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"LW.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":94},"Nextclade_pango":{"value":"LW.1.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1","node_attrs":{"div":70,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"LW.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.2","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"LW.1.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000765","node_attrs":{"div":65,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"KP.3.1.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.7"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.8"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MY.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"qc.overallScore":{"value":0.174},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MM.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MM.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000768","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":90},"Nextclade_pango":{"value":"KP.3.1.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MK.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":68,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MK.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":95},"Nextclade_pango":{"value":"MK.3"},"ace2_binding":{"value":"-1.11924"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"qc.overallScore":{"value":0.694},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7206397516519647"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"clade_nextstrain":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"KP.3.1.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24C (KP.3)"},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000770","node_attrs":{"div":67,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"KP.3.1.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.10"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.12"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.14"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.02898645401001}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.16","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.16"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-3.910944700241089}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.15","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.15"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.3","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.3"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.6","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.6"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.3801984786987305}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.4","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.4"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.5","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.5"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.7","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.7"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5369762101413171"},"placement_prior":{"value":-6.544749736785889}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.9"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.347929000854492}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000771","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.11"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.11.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000772","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.13"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.13.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2.1","node_attrs":{"div":69,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.2.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.050478935241699}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}},{"name":"MC.2","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":92},"Nextclade_pango":{"value":"MC.2"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"clade_nextstrain":{"value":"24E"},"Nextclade_pango":{"value":"MC.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8.1","node_attrs":{"div":72,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":93},"Nextclade_pango":{"value":"MC.8.1"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}},{"name":"MC.8","node_attrs":{"div":68,"designation_recency":{"value":"4-8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":91},"Nextclade_pango":{"value":"MC.8"},"ace2_binding":{"value":"-1.15353"},"clade_display":{"value":"24E (KP.3.1.1)"},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"clade_nextstrain":{"value":"21L"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"placement_prior":{"value":-3.5445594787597656}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000776","node_attrs":{"div":5,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-4.484652996063232}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.4.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.484652996063232}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000777","node_attrs":{"div":6,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000778","node_attrs":{"div":7,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"placement_prior":{"value":-2.9143002033233643}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.222130537033081}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.3","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.5","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.7"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.027554035186768}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000779","node_attrs":{"div":10,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"placement_prior":{"value":-2.785705327987671}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.1","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-09-05"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9799063205718994}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-2.785705327987671}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.4.6.3"},"ace2_binding":{"value":"0.71883"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.2","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.4.6.2"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9107766151428223}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000780","node_attrs":{"div":11,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.6.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DC.1"},"ace2_binding":{"value":"0.66094"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000781","node_attrs":{"div":7,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":7,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-05-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7295260429382324}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.4.1.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"22A"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.8587093353271484}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.4.1.9"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000782","node_attrs":{"div":8,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.4.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.4.1.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000783","node_attrs":{"div":9,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BA.4.1.11"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000784","node_attrs":{"div":11,"clade_nextstrain":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.4.1.10"},"ace2_binding":{"value":"0.67074"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5308081831240151"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CS.1"},"ace2_binding":{"value":"0.5702799999999999"},"clade_display":{"value":"22A (BA.4)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.7561969850799493"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000785","node_attrs":{"div":12,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-3.195547103881836}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":12,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.195547103881836}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.9"},"ace2_binding":{"value":"0.39901000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.2395057678222656}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"NODE_0000786","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-4.000418663024902}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"ORF1a":["M2096L"]},"labels":{"aa":"ORF1a: M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000787","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"placement_prior":{"value":-2.946962833404541}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.946962833404541}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.5.2","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.5.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.243049144744873}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"NODE_0000788","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"placement_prior":{"value":-2.891695499420166}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.5.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-3.5131309032440186}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"placement_prior":{"value":-3.0766263008117676}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0766263008117676}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000790","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"placement_prior":{"value":-3.1130268573760986}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.6.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9632551670074463}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.6.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.4","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.6.4"},"ace2_binding":{"value":"0.5883099999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000791","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.6.2"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BW.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BW.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BW.1.2"},"ace2_binding":{"value":"0.6570799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000793","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BW.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BW.1.1.1"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BW.1.1.2"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BW.1.1"},"ace2_binding":{"value":"0.77355"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000794","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-2.2668097019195557}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"]}},"children":[{"name":"BA.5.1","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":50},"Nextclade_pango":{"value":"BA.5.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.2668097019195557}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.12"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.4273552894592285}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.11","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.14","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.14"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.96599817276001}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.16"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.954094409942627}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.17"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7746376991271973}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2638373374938965}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.24"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3640358448028564}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.28"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.258039951324463}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.150360584259033}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.30"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.9021801948547363}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.34"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.1470396518707275}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.4","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.6","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.541717767715454}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.7","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.7"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.88628888130188}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.8","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6331071853637695}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0000795","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BK.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.15"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DL.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000797","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DH.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000798","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.26"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CU.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.303286075592041}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.1.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.38"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000800","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.1.33"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"EQ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_8226","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.35"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"EB.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_bae4","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"placement_prior":{"value":-3.846775770187378}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.23"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.846775770187378}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"placement_prior":{"value":-3.115823268890381}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DE.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"DE.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0000804","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.430187463760376}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.5.1.18"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000805","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"placement_prior":{"value":-4.06973934173584}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.06973934173584}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BT.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BT.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"placement_prior":{"value":-3.8074188232421875}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.25"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8074188232421875}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"placement_prior":{"value":-5.113685607910156}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"DJ.1"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.113685607910156}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000808","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"placement_prior":{"value":-5.255130290985107}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"DJ.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DJ.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000809","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DJ.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DJ.1.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-3.5218355655670166}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.27"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7831978797912598}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.1.29"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CL.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0000813","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"placement_prior":{"value":-4.229829788208008}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CL.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0000814","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-2.733313798904419}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0832855701446533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.1.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.0474534034729}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.32"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.180713653564453}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000815","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"placement_prior":{"value":-4.133322715759277}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.20"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.535171985626221}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.36","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.1.36"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.1.37"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"placement_prior":{"value":-3.151113748550415}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.793166160583496}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000818","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BA.5.10.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000819","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DF.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"DF.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DF.1.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0000820","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-3.7016499042510986}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7016499042510986}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000821","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.677614212036133}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.2.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.677614212036133}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BF.12"},"ace2_binding":{"value":"0.5279"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9531965255737305}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.14"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-3.077155351638794}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"ORF1b":["H1087Y"],"S":["N450D"]},"labels":{"aa":"ORF1b: H1087Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.19","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.17","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.17"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.485513687133789}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.18","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.18"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.091020107269287}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.30"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.33"},"ace2_binding":{"value":"0.6034899999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.5511837005615234}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.6"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9146251678466797}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.488147020339966}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000822","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.31"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"placement_prior":{"value":-4.266521453857422}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BF.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.266521453857422}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.31.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.39"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"placement_prior":{"value":-4.000523567199707}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.39.1"},"ace2_binding":{"value":"0.33263"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5959379308450252"},"placement_prior":{"value":-5.37965726852417}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.39"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.000523567199707}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.41"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"placement_prior":{"value":-4.131745338439941}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.41.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.41","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.41"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.131745338439941}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000825","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.462851524353027}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.11.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000826","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"placement_prior":{"value":-5.1659932136535645}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.11.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.292901039123535}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.11.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0000827","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.7677369117736816}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7894070148468018}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.28"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2664027214050293}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.35","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.35"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T9727C","C12789T","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"],"S":["N450D"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.36","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.36"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.462024211883545}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000828","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"placement_prior":{"value":-3.4317872524261475}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4317872524261475}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000829","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.10"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"placement_prior":{"value":-3.138411521911621}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.10.1"},"ace2_binding":{"value":"0.3218"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.563032084337257"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.138411521911621}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000830","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-3.120866537094116}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.15"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.382185459136963}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.20"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.540201187133789}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000831","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-3.864048957824707}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.27"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3812055587768555}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000832","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.4586398601531982}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.13"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.780573606491089}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.16"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.25"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BF.29"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.740543842315674}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.34"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-4.685749530792236}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.23"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.741713047027588}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"placement_prior":{"value":-4.337294578552246}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.337294578552246}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.3.1"},"ace2_binding":{"value":"0.48889999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.257171630859375}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000835","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-4.661863803863525}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.24"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000836","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-4.16046142578125}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BF.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.16046142578125}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000837","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-2.7555088996887207}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.5.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000838","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.266281604766846}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000839","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-2.605588436126709}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000840","node_attrs":{"div":25,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.5.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":44,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BF.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-08"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}}]}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.6039862632751465}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.42"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF7b:14-44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"placement_prior":{"value":-2.397184133529663}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.26"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.32"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.257172107696533}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.37"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.416947364807129}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.40"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.287396192550659}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.38"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"placement_prior":{"value":-4.238620281219482}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.38.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BF.38"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.238620281219482}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.38.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}},{"name":"BF.38.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.38.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}}]},{"name":"NODE_0000844","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.10"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.11","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.11"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.12"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.15"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.17"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.18"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.20","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.20"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.21","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.21"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.2"},"ace2_binding":{"value":"0.6393200000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.22","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.22"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.9261090755462646}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.26","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.26"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.24","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BF.7.24"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.23","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.23"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.092196941375732}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.9"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"BF.7.8","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000845","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.16"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.16.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000846","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.19"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.19"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.19.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0000847","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.5"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.5.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000848","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.13"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.13"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.13.1"},"ace2_binding":{"value":"0.6759999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.13.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}}]},{"name":"NODE_0000849","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BF.7.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BF.7.4.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000850","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.4.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.3122618198394775}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BF.7.4.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0000851","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BF.7.27"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000852","node_attrs":{"div":26,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BF.7.14.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.4","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.5","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.325514793395996}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0000853","node_attrs":{"div":27,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BF.7.14.3"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BF.7.14.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000854","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-2.6320736408233643}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.23"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-3.815145969390869}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.182581424713135}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.40"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.9"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.9923183917999268}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000855","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-1.9060567617416382}},"branch_attrs":{"mutations":{"nuc":["C16616A","C27012T","C27513T"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.12"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.3895606994628906}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.14","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.14"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.13","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.13"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.6929638385772705}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.19","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.19"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7767930030822754}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.22","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.22"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4965717792510986}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.29","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.29"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.456769943237305}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.28","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.28"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.146134376525879}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.30","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.30"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-4.523482322692871}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.34","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.34"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.511476755142212}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.35"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.6543288230895996}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.37"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.394333839416504}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.39"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.5.2.42"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.43"},"ace2_binding":{"value":"0.5642800000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5413273873731987"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.44"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.278106212615967}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.46"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.212985038757324}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.45","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.45"},"ace2_binding":{"value":"0.5131699999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.998797416687012}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.54","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.54"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.164445877075195}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.53","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.53"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.224037170410156}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.52","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.52"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.105970859527588}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.55"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9875283241271973}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.59"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.192619323730469}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.5.2.58","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.58"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.236825942993164}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.57"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.694666862487793}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.62"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.162878036499023}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.61","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.61"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.711515426635742}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.63","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BA.5.2.63"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.8","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.8"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9411776065826416}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.285115718841553}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.32"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.365017890930176}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"placement_prior":{"value":-3.7827541828155518}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.27"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7827541828155518}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CF.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.796359539031982}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"NODE_0000858","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.33"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CE.1"},"ace2_binding":{"value":"0.39901000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3798828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"internal_1651","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"placement_prior":{"value":-4.1625542640686035}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.36"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.1625542640686035}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CT.1"},"ace2_binding":{"value":"0.4564899999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7208595659836455"},"placement_prior":{"value":-5.671617031097412}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"placement_prior":{"value":-4.313873291015625}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.38"},"ace2_binding":{"value":"0.56458"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.30660604695253"},"placement_prior":{"value":-4.313873291015625}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DA.1"},"ace2_binding":{"value":"0.6759999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"placement_prior":{"value":-5.4733147621154785}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000861","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.41"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.635266304016113}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.56"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.0257768630981445}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.47"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DQ.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000863","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"placement_prior":{"value":-3.0985805988311768}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.20"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0985805988311768}},"branch_attrs":{"mutations":{}}},{"name":"BV.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BV.2"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.277459144592285}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}},{"name":"BV.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BV.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}}]},{"name":"NODE_0000864","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"placement_prior":{"value":-3.4673714637756348}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.21"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.4673714637756348}},"branch_attrs":{"mutations":{}}},{"name":"CN.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CN.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}},{"name":"CN.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"CN.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_6217","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BZ.2"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BZ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.31"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CD.1"},"ace2_binding":{"value":"0.35979999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"placement_prior":{"value":-5.5325236320495605}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CD.2"},"ace2_binding":{"value":"0.5594199999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3253063676642168"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0000867","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.49"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DZ.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DZ.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]},{"name":"NODE_0000868","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-4.059089183807373}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.50"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.723017692565918}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.51","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.51"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BA.5.2.60"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000869","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.7"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CY.2"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CY.1"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.678462505340576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0000870","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"placement_prior":{"value":-3.246659517288208}},"branch_attrs":{"mutations":{"nuc":["T27012C","T27513C"]}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BA.5.2.10"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.743002891540527}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6277518272399902}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000871","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"placement_prior":{"value":-3.8559513092041016}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.26"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8559513092041016}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CG.1"},"ace2_binding":{"value":"0.36874999999999986"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]}]},{"name":"internal_a7d2","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.16"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BU.1"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.204470634460449}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BU.3"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}},{"name":"BU.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BU.2"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.25"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"DB.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.356487274169922}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"DB.2"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DB.3","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"DB.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}}]},{"name":"internal_93c4","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.18"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.018024444580078}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CR.2"},"ace2_binding":{"value":"0.45785000000000003"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.905637264251709}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0000876","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"placement_prior":{"value":-4.66331672668457}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CR.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.66331672668457}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000877","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"placement_prior":{"value":-4.36233377456665}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CR.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CR.1.2"},"ace2_binding":{"value":"0.40216999999999997"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CR.1.3"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000878","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.2.48"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7050411701202393}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000879","node_attrs":{"div":25,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"DY.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"DY.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}}]},{"name":"NODE_0000880","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"placement_prior":{"value":-3.8912155628204346}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.5254948139190674}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"DY.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7626357078552246}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"placement_prior":{"value":-3.2016091346740723}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-3.2016091346740723}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.3"},"ace2_binding":{"value":"0.38661"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"placement_prior":{"value":-4.828918933868408}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.2"},"ace2_binding":{"value":"0.6942999999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.5295255377787571"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.6","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.6"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.885843276977539}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.7","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CP.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.4","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.4"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.628321170806885}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.973639488220215}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"internal_7ebe","node_attrs":{"div":24,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CP.8"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"CP.8.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}}]},{"name":"NODE_0000883","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CP.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"CP.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CP.1.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-5.384389877319336}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.1.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-5.319447994232178}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}},{"name":"CP.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CP.1.3"},"ace2_binding":{"value":"0.6003199999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF8:117-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.6214095378573192"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"internal_605c","node_attrs":{"div":20,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"placement_prior":{"value":-4.047678470611572}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BA.5.2.24"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.047678470611572}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.240954875946045}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CK.2"},"ace2_binding":{"value":"0.40293000000000007"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"placement_prior":{"value":-4.374808311462402}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.2.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.374808311462402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000887","node_attrs":{"div":27,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CK.2.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DG.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0000888","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.068136215209961}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"CK.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.068136215209961}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0000889","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.982324123382568}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CK.1.2"},"ace2_binding":{"value":"0.71883"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.998134136199951}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CK.1.3"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.711119651794434}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0000890","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"placement_prior":{"value":-4.607345104217529}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.4"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.5"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0000891","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CK.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CK.1.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"CK.1.1"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"CK.1.1.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.657632827758789}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]},{"name":"NODE_0000892","node_attrs":{"div":13,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"placement_prior":{"value":-4.171703815460205}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"ORF1a":["Q556K"]},"labels":{"aa":"ORF1a: Q556K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":13,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":51},"Nextclade_pango":{"value":"BA.5.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.171703815460205}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"frameShifts":{"value":"ORF7a:72-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.7826950550079346}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.5"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.3075408935546875}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000893","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"placement_prior":{"value":-3.80965518951416}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9212589263916016}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.250945091247559}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}}]},{"name":"NODE_0000894","node_attrs":{"div":14,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BA.5.3.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{}}},{"name":"BE.3","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.2200913429260254}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.5"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.279566287994385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000895","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.430433750152588}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.10"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.9"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.668551206588745}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000896","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.247138023376465}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-","T28693C"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.13"},"ace2_binding":{"value":"0.5231200000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.5088823627149919"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":1},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.8"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.8"},"qc.overallScore":{"value":56.25},"totalAminoacidDeletions":{"value":94},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]},{"name":"NODE_0000897","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-3.7212204933166504}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.12","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.12"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":52},"Nextclade_pango":{"value":"BE.11"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.008347988128662}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0000898","node_attrs":{"div":16,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.290442943572998}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T"],"ORF1a":["M85-"]},"labels":{"aa":"ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.6"},"ace2_binding":{"value":"0.5513799999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.737891674041748}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.7"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.395222187042236}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000899","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"placement_prior":{"value":-4.679184913635254}},"branch_attrs":{"mutations":{"nuc":["C13342T"]}},"children":[{"name":"BE.2","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.8559343814849854}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G"],"ORF1a":["T882I"]},"labels":{"aa":"ORF1a: T882I"}}},{"name":"NODE_0000900","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{"nuc":["C10188A","C27800T"],"ORF1a":["T3308N"]},"labels":{"aa":"ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000901","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"placement_prior":{"value":-4.281903266906738}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.4.2"},"ace2_binding":{"value":"0.60741"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.614480018615723}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000902","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.4.1"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000903","node_attrs":{"div":22,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.4.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"CQ.2"},"ace2_binding":{"value":"0.40216999999999997"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"placement_prior":{"value":-3.9200549125671387}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000904","node_attrs":{"div":23,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"CQ.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"CQ.1.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CQ.1"},"ace2_binding":{"value":"0.5692699999999998"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000905","node_attrs":{"div":15,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"placement_prior":{"value":-3.0249295234680176}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"ORF1b":["M1156I"]},"labels":{"aa":"ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":53},"Nextclade_pango":{"value":"BE.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.0249295234680176}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BE.1.3"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000906","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"placement_prior":{"value":-4.295778751373291}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.295778751373291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000907","node_attrs":{"div":21,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BE.1.2.1"},"ace2_binding":{"value":"0.5026299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6938954632982287"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"DW.1"},"ace2_binding":{"value":"0.49383999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8224959014481948"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000908","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.4.4"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BE.1.4.3"},"ace2_binding":{"value":"0.39120999999999995"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0000909","node_attrs":{"div":18,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"placement_prior":{"value":-4.36769437789917}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.4.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BE.1.4.2"},"ace2_binding":{"value":"0.6697299999999999"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000910","node_attrs":{"div":17,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"placement_prior":{"value":-2.7709972858428955}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":54},"Nextclade_pango":{"value":"BE.1.1"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-2.7709972858428955}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000911","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.1.2"},"ace2_binding":{"value":"0.5583100000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"CC.1"},"ace2_binding":{"value":"0.4997300000000001"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000912","node_attrs":{"div":19,"clade_nextstrain":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"placement_prior":{"value":-4.0404744148254395}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":55},"Nextclade_pango":{"value":"BE.1.1.1"},"ace2_binding":{"value":"0.45952999999999994"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-08-24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"placement_prior":{"value":-4.0404744148254395}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":56},"Nextclade_pango":{"value":"BQ.2"},"ace2_binding":{"value":"0.45205000000000006"},"clade_display":{"value":"22B (BA.5)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5680790723509552"},"placement_prior":{"value":-4.677975654602051}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000913","node_attrs":{"div":21,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-3.3798208236694336}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.3798208236694336}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.12"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.383481740951538}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.14"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4368515014648438}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.17"},"ace2_binding":{"value":"0.57323"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.728248596191406}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.19"},"ace2_binding":{"value":"0.6127800000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7257362514460642"},"placement_prior":{"value":-4.9549241065979}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.20"},"ace2_binding":{"value":"0.5446"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8308113969466171"},"placement_prior":{"value":-4.456951141357422}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.21"},"ace2_binding":{"value":"0.6570799999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.24"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.423928260803223}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.31"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.428604602813721}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.32"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.33"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.945977687835693}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.5"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4588372707366943}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.4"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.7"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.903951168060303}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.6"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.9833500385284424}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.9"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.657703399658203}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000914","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.11"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.11.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000915","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.13.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}},{"name":"BQ.1.13","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.13"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000916","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.29","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.29"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}},{"name":"BQ.1.28","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.28"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}}]},{"name":"NODE_0000917","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"placement_prior":{"value":-4.865876197814941}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.15"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.865876197814941}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"placement_prior":{"value":-4.009592056274414}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.15.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.111164569854736}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}},{"name":"BQ.1.15.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.15.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.30"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"placement_prior":{"value":-4.176229953765869}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.25"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.176229953765869}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.25.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8304200172424316}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000921","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"placement_prior":{"value":-5.710468292236328}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.26"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.710468292236328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000922","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.26.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.26.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000923","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.3.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.3.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":57},"Nextclade_pango":{"value":"BQ.1.10"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"internal_fdc9","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.2"},"ace2_binding":{"value":"0.6353800000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6853534127590314"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.10.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EC.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EC.1.1"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"EC.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EC.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.2.3"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.687568426132202}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"internal_dbfb","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.2.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FB.2"},"ace2_binding":{"value":"0.5174000000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6925976779449897"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}},{"name":"FB.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FB.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}}]},{"name":"NODE_0000930","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JH.1"},"ace2_binding":{"value":"0.66664"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9874397743924017"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000931","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BQ.1.2.2"},"ace2_binding":{"value":"0.60833"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9373817650831857"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":67},"Nextclade_pango":{"value":"JH.2"},"ace2_binding":{"value":"0.6059300000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"frameShifts":{"value":"ORF7a:83-122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":31},"immune_escape":{"value":"1.0821590912755812"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"placement_prior":{"value":-2.758084297180176}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.16","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.16"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.18","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.18"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.5462334156036377}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":58},"Nextclade_pango":{"value":"BQ.1.23"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.4519829750061035}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.22"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.056916236877441}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.27"},"ace2_binding":{"value":"0.49690999999999996"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"placement_prior":{"value":-4.634747505187988}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.8"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.8.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.8.2"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FF.1"},"ace2_binding":{"value":"0.66401"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000935","node_attrs":{"div":23,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-2.3916101455688477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1.11","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.11"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-3.890984058380127}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1","node_attrs":{"div":23,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-09-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-2.3916101455688477}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.12"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-4.536876678466797}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.16"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.6093573570251465}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.17"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.1477370262146}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.19"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.224153995513916}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.20"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.21"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"frameShifts":{"value":"ORF8:122"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.24"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9906511306762695}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.25"},"ace2_binding":{"value":"0.7449699999999998"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9883317000263399"},"placement_prior":{"value":-4.071465015411377}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.26"},"ace2_binding":{"value":"0.5921799999999998"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8728938682420008"},"placement_prior":{"value":-4.841145992279053}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.30"},"ace2_binding":{"value":"0.60833"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9373817650831857"},"placement_prior":{"value":-4.599907875061035}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.31"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8225269317626953}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.34"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-5.100788593292236}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.36"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.200608253479004}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.37"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.312097549438477}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.42"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.227291584014893}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.41"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9046671390533447}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.40"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.9314393997192383}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.45"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6982264518737793}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.47"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.249356746673584}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.44"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.04910135269165}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.50"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.385881423950195}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.51"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.995375394821167}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.55"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.858496189117432}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.57"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.359898567199707}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.58"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.377610206604004}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.56"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.5291290283203125}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.60"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.216671943664551}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.6"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.973461389541626}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.63"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.370896339416504}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.64"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.916772365570068}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.68"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.0179009437561035}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.67"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.056059837341309}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.66"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.271934509277344}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.69"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6361539363861084}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.70"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8411049842834473}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.73"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.75"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.051732686328446"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.76"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.239201068878174}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.77"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.6623735427856445}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.9"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.718957901000977}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"placement_prior":{"value":-5.200210094451904}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.14"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.200210094451904}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"CW.1"},"ace2_binding":{"value":"0.70602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-5.546139240264893}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000937","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"placement_prior":{"value":-3.995506525039673}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.15"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.995506525039673}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"DM.1"},"ace2_binding":{"value":"0.65602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"placement_prior":{"value":-4.960502624511719}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"placement_prior":{"value":-4.099379062652588}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-19"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.099379062652588}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DU.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000939","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.9369025230407715}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.23"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.7810332775115967}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.27"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-02"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.529773712158203}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000940","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.500676155090332}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.29"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.79"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.35"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"ET.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000942","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"placement_prior":{"value":-4.477259635925293}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.65"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.477259635925293}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"ES.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.6746344566345215}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000943","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"placement_prior":{"value":-3.848482608795166}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.7"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.848482608795166}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DK.1"},"ace2_binding":{"value":"0.74371"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8470101435700336"},"placement_prior":{"value":-4.994816303253174}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"placement_prior":{"value":-4.450067520141602}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.72"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.450067520141602}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FC.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.900752067565918}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000945","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.8"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DP.1"},"ace2_binding":{"value":"0.66913"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9105813557217661"},"placement_prior":{"value":-4.242033958435059}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"placement_prior":{"value":-3.8017337322235107}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.8017337322235107}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"CZ.1"},"ace2_binding":{"value":"0.6774299999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9883317000263399"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"CZ.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000947","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"placement_prior":{"value":-3.908764600753784}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.10"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.908764600753784}},"branch_attrs":{"mutations":{}}},{"name":"FA.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FA.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"FA.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"FA.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.795900344848633}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000948","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"placement_prior":{"value":-4.109678745269775}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.22"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.109678745269775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000949","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"ER.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"placement_prior":{"value":-4.9500412940979}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"ER.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ER.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.9500412940979}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000950","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"placement_prior":{"value":-3.677809476852417}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.677809476852417}},"branch_attrs":{"mutations":{}}},{"name":"DR.2","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"DR.2"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-4.493982315063477}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"DR.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"DR.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.548750877380371}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}}]},{"name":"NODE_0000951","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.46"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000952","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EN.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EN.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EN.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000953","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.6486151218414307}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.48"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.381720066070557}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.49"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.766873836517334}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.78"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"placement_prior":{"value":-4.132527828216553}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.52"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.132527828216553}},"branch_attrs":{"mutations":{}}},{"name":"EA.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EA.2"},"ace2_binding":{"value":"0.34834999999999994"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.880706782961692"},"placement_prior":{"value":-4.9180803298950195}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}},{"name":"EA.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EA.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.47806978225708}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"placement_prior":{"value":-4.497543811798096}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.53"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.497543811798096}},"branch_attrs":{"mutations":{}}},{"name":"FM.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FM.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.829411506652832}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}},{"name":"FM.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"FM.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"placement_prior":{"value":-3.49872088432312}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.18"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.49872088432312}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"ED.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6314659118652344}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ED.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.1880316734313965}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"ED.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.8974103927612305}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000957","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.166533946990967}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.54"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.59"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000958","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"placement_prior":{"value":-4.4338603019714355}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.28"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.4338603019714355}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EH.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"placement_prior":{"value":-4.000490188598633}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.32"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.000490188598633}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DT.1"},"ace2_binding":{"value":"0.7242"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DT.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.651244640350342}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"DT.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.224050998687744}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"NODE_0000960","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{"nuc":["T7633C","C22314T","A24129G"],"S":["P251L","N856S"]},"labels":{"aa":"S: P251L, N856S","spike_mutations":"P251L, N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.38"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EW.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EW.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EW.3"},"ace2_binding":{"value":"0.65602"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-4.116559982299805}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.62"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-3.4302690029144287}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.61"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000963","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.43"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EZ.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"placement_prior":{"value":-3.492278814315796}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"BQ.1.1.4"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.492278814315796}},"branch_attrs":{"mutations":{}}},{"name":"EE.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.131551265716553}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.1","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.184211254119873}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.4","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.4"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.840254783630371}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":59},"Nextclade_pango":{"value":"EE.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.185059070587158}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EE.5"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.522100448608398}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}}]},{"name":"NODE_0000965","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"placement_prior":{"value":-4.684232711791992}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.74"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.684232711791992}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"FN.1"},"ace2_binding":{"value":"0.6288199999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000966","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"placement_prior":{"value":-6.281740188598633}},"branch_attrs":{"mutations":{"nuc":["C22314T","T23716C","A28834G"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000967","node_attrs":{"div":30,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"BQ.1.1.39"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":65},"Nextclade_pango":{"value":"FQ.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-04-17"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000968","node_attrs":{"div":31,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"BQ.1.1.71"},"ace2_binding":{"value":"0.24659999999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-03"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"EV.1"},"ace2_binding":{"value":"0.24659999999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0000969","node_attrs":{"div":24,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"placement_prior":{"value":-4.140890598297119}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"BQ.1.1.13"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.140890598297119}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.071533679962158}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":25,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000971","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"placement_prior":{"value":-4.138623237609863}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.22083044052124}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"placement_prior":{"value":-4.127103805541992}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":60},"Nextclade_pango":{"value":"EF.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.127103805541992}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000973","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"EF.1.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"EY.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000974","node_attrs":{"div":26,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":61},"Nextclade_pango":{"value":"BQ.1.1.5"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.2"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-3.6995480060577393}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000975","node_attrs":{"div":27,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3","node_attrs":{"div":27,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"DN.3.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-7.322900772094727}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0000976","node_attrs":{"div":28,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"placement_prior":{"value":-4.858262538909912}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":62},"Nextclade_pango":{"value":"DN.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.858262538909912}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000977","node_attrs":{"div":29,"clade_nextstrain":{"value":"22E"},"Nextclade_pango":{"value":"DN.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1.1","node_attrs":{"div":34,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":66},"Nextclade_pango":{"value":"DN.1.1.1"},"ace2_binding":{"value":"2.05606"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8990816968865659"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.3"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1","node_attrs":{"div":29,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":63},"Nextclade_pango":{"value":"DN.1.1"},"ace2_binding":{"value":"0.77543"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.2","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.2"},"ace2_binding":{"value":"0.5626099999999999"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8771384492554943"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"designation_recency":{"value":">8 weeks"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"qc.frameShifts.totalFrameShifts":{"value":0},"totalAminoacidSubstitutions":{"value":64},"Nextclade_pango":{"value":"DN.1.1.4"},"ace2_binding":{"value":"0.6722600000000001"},"clade_display":{"value":"22E (BQ.1)"},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"qc.overallScore":{"value":0.0},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8744814686582322"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MAHSNGTITVEELKKLLEEWNLVIGFLFLAWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFVRTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNKLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKDSCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTLVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDSLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNITLIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLFLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTIKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITTTQLPPAYTNSFTRGVYYPDKVFRSSVLHLTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVFIKVCEFQFCNDPFLDVYYHKNNKSWMESESGVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLGRDFPQGFSALEPLVDLPIGINITRFQTLLALNRSYLTPGDSSSGWTAGAADYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNVTNLCPFHEVFNATRFASVYAWNRTRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIKGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKHSGNYDYWYRLFRKSKLKPFERDISTEIYQAGNKPCKGVKGPNCYFPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTKSNKKFLPFQQFGRDIVDTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVSVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSRRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLFSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQLELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCTAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGATTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACATTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAGCCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACTTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTACTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTATTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAATAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAACGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCACAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCGCTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACTACAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTTAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTTTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTCAGGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGGGCGTGATTTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTAAATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGATTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATGTTACAAACTTGTGCCCTTTTCATGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGACGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAAAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGCATAGTGGTAATTATGATTACTGGTATAGATTGTTTAGGAAGTCTAAACTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAAAGGTGTTAAAGGTCCTAATTGTTACTTTCCTTTACAATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTAAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGTTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCTCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCGTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTTTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACTTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTATATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCACATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTGCATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTTCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGTGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACAAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/BA.2/tree.json b/data/nextstrain/sars-cov-2/BA.2/tree.json index dd722505..a297219d 100644 --- a/data/nextstrain/sars-cov-2/BA.2/tree.json +++ b/data/nextstrain/sars-cov-2/BA.2/tree.json @@ -1 +1 @@ -{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["E31-","R32-","S33-"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF9b":["E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S"]},"labels":{"aa":"N: E31-, R32-, S33-; ORF1a: S3675-, G3676-, F3677-; ORF9b: E27-, N28-, A29-; S: L24-, P25-, P26-, A27S","clade":"Omicron","spike_mutations":"L24-, P25-, P26-, A27S"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2"},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.14300012588501}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAB","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAB"},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.431697368621826}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAA","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAA"},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAE","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAE"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAD","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAD"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.878465175628662}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAC","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAC"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAF"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAH","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAH"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.748097896575928}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAG","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAG"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.583486080169678}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAL","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAL"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAJ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAJ"},"designation_date":{"value":"2022-07-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.648314476013184}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAK","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAK"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3037714005953052"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAQ","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAQ"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAN","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAN"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081246376037598}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAM","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAM"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAP","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAP"},"designation_date":{"value":"2022-07-30"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.999915599822998}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAR","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAR"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.451335430145264}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAT","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAT"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.875851154327393}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAU","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAU"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.17326545715332}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAS","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAS"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.452675819396973}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":82,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAW"},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.274687314409391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E156-","F157-","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAV","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAV"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.7257537841796875}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAZ","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAZ"},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.731168270111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBA"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.29808642936638835"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBD"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBE"},"designation_date":{"value":"2022-10-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.574320316314697}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBG","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBG"},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBH"},"designation_date":{"value":"2022-11-16"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBM","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBM"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBN","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBN"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBP","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBP"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBR"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBS"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBT"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5037920175803539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBQ"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBY","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBY"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBW"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBV"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBZ","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBZ"},"designation_date":{"value":"2023-03-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBU","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBU"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCB"},"designation_date":{"value":"2023-04-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCA"},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XCC","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCC"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCD"},"designation_date":{"value":"2023-06-08"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCE"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCG"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCJ"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCL","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCL"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCK","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCK"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCM","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCM"},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCN"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCP","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCP"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCQ","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCQ"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCR","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCR"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCS","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCS"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCU","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCU"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCV"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCY","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCY"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCW","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCW"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XDB","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDB"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XCZ","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCZ"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XDC","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDC"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDE"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDF"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDH"},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDJ","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDJ"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDG"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDM","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDM"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDN","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDN"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDL","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDL"},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDS","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDS"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDU","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDU"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9475349114594978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDT"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDY","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDY"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDW"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XDZ","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDZ"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XE","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XE"},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEB","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEB"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEA","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEA"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2268340125514634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XED"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":17.361},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XED"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEF","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEF"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":34.028},"immune_escape":{"value":"1.7268345560655398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEG"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":950.694},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEE","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEE"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.013909339904785}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XG"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XJ","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XJ"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XH","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XH"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XL","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XL"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XK","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XK"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XM","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XM"},"designation_date":{"value":"2022-03-31"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.148608207702637}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XN","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XN"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.339982509613037}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XR","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XR"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XT","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XT"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.084201812744141}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XP","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XP"},"designation_date":{"value":"2022-04-01"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3616394203564539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.0015506744384766}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XQ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XQ"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.572240829467773}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XW","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XW"},"designation_date":{"value":"2022-05-12"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XV","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XV"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.536291122436523}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XU","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XU"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XZ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XZ"},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.089031219482422}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XY"},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"partiallyAliased":{"value":"XBK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"partiallyAliased":{"value":"XCH"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH.1"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9920809268951416}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"partiallyAliased":{"value":"XCT"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT.1"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"partiallyAliased":{"value":"XDA"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"partiallyAliased":{"value":"XEC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC.1"},"designation_date":{"value":"2024-08-14"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":29.34},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":34.028},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.1"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}},{"name":"XCF.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.2"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.1"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.2"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"partiallyAliased":{"value":"XDR"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"partiallyAliased":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.2"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}},{"name":"XDR.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.1"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.2"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.1"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"partiallyAliased":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.083851337432861}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.083851337432861}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49430513381958}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.2"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.3"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1974196434021}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"partiallyAliased":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.3"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.4"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.2"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"internal_63f4","node_attrs":{"div":37,"partiallyAliased":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.3"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"partiallyAliased":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"partiallyAliased":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.3"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.5"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XDK.4.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.6"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":61,"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"NODE_0000033","node_attrs":{"div":62,"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.10","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.10"},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.10"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.2943291664123535}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.9","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.9"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.9"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"partiallyAliased":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116386413574}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116386413574}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1.1"},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"partiallyAliased":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"partiallyAliased":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":53,"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY"},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":53,"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.3"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":56,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":57,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1506476402282715}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.997220516204834}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":58,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1506476402282715}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.697917461395264}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}},{"name":"XAY.2.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":60,"partiallyAliased":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.2"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":62,"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000046","node_attrs":{"div":63,"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":64,"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":65,"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.682617664337158}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.2","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}},{"name":"GL.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752889267417711"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.494446754455566}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"partiallyAliased":{"value":"XDV"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"partiallyAliased":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.10"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.11"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.3"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.5"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5359962252743784"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14808999999999992"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.4","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.4"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.8"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"partiallyAliased":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":6.25},"immune_escape":{"value":"1.8051577060608006"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26874999999999993"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}},{"name":"XDV.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000052","node_attrs":{"div":60,"partiallyAliased":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5422010449483097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20783000000000001"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]},{"name":"NODE_0000053","node_attrs":{"div":61,"partiallyAliased":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":68,"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC"},"designation_date":{"value":"2022-09-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":68,"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.2.1"},"designation_date":{"value":"2023-03-19"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.44507236664312827"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}},{"name":"XBC.2","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"XBC.2"},"designation_date":{"value":"2022-10-14"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"totalAminoacidSubstitutions":{"value":58},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}}]},{"name":"NODE_0000057","node_attrs":{"div":70,"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"XBC.1"},"designation_date":{"value":"2022-10-03"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"totalAminoacidSubstitutions":{"value":57},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.187767505645752}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":76,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.4"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":75,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.5"},"designation_date":{"value":"2023-02-26"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000059","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":78,"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":79,"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48837241784414276"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1.2"},"designation_date":{"value":"2023-06-10"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":76,"partiallyAliased":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":76,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7"},"designation_date":{"value":"2023-06-10"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7.1"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7.2"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":79,"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.1","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.2"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.3","node_attrs":{"div":81,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.3"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":83,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.4"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":84,"partiallyAliased":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":84,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6"},"designation_date":{"value":"2023-03-16"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.2"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":87,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.4"},"designation_date":{"value":"2023-06-14"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":88,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.5"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":85,"partiallyAliased":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":88,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.1.1"},"designation_date":{"value":"2023-06-14"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.1"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":87,"partiallyAliased":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":89,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.6.1"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7550301657183831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"JT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":87,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.6"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":86,"partiallyAliased":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":86,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":89,"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.2","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1"},"designation_date":{"value":"2023-08-02"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}},{"name":"HW.1.1","node_attrs":{"div":92,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"designation_date":{"value":"2023-08-02"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420325830319254"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.9"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0810114368008295"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26627999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}},{"name":"XBB.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3064099999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000075","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.7"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000077","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000078","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.1"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.2"},"designation_date":{"value":"2023-06-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000079","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.2"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.4"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.5"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000080","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.3"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}},{"name":"XBB.3.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122062683105469}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122062683105469}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.12"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.4"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.165234565734863}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.9"},"designation_date":{"value":"2023-05-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54503870010376}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.8"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.256869792938232}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"internal_619ad3bd","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143047332764}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143047332764}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11.1"},"designation_date":{"value":"2023-06-11"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65097"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000084","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.83268404006958}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.10"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000085","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.1"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.2"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000086","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.2"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.3"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.6","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000087","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067752838134766}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35217"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35217"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067752838134766}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000088","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.583855628967285}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.14"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.900240898132324}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.18"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2567103717994188"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0750199999999999"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.20"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.21"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.22"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.5"},"designation_date":{"value":"2023-04-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84876"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.42367696762085}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.7"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.456076145172119}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.9"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675187587738037}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.92117"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.92117"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675187587738037}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343238830566}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13359999999999994"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.8618388175964355}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343238830566}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.036584854125977}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0527558336884004"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84789"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.918221950531006}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90647"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.901963710784912}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.16"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84876"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.17"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89912"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.88039"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.88039"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736186906064397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89932"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}},{"name":"GM.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647790908813477}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647790908813477}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000102","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0079043361863298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7709600000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.985507965087891}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.762627124786377}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000104","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.607783317565918}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.551803112030029}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}},{"name":"GS.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000106","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651515960693}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651515960693}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030636310577393}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030636310577393}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.517807483673096}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704747676849365}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704747676849365}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.6","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000112","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.451866626739502}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"internal_bb69915a","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103416442871}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103416442871}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.436974048614502}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.436974048614502}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.918066501617432}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.918066501617432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000118","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.826663017272949}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.56931734085083}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"internal_d2763520","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000120","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.986824739722089"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.70075"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000121","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000123","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000124","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.257803916931152}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.257803916931152}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000125","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.203644752502441}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13359999999999994"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GJ.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"designation_date":{"value":"2023-06-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000131","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89912"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.32551383972168}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.32551383972168}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000135","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734275817871}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734275817871}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.842318534851074}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_XBB1_out","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.060752868652344}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.060752868652344}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.10"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13558"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.3"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49564"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.381250858306885}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000137","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980052947998}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.33"},"designation_date":{"value":"2023-04-18"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0545"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.49"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89405"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.542015552520752}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.20"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.48"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.9722600000000003"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000139","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.2"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"XBB.1.19","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000141","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000142","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000143","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000144","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000145","node_attrs":{"div":54,"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.2","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"internal_ORF8stop","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1269187927246094}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.21"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86729"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.27"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2602599999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.29"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.36"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3860321044921875}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.40"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.7"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.885027885437012}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.6"},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.8"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000147","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12"},"designation_date":{"value":"2023-02-09"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12.1"},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}},{"name":"XBB.1.13","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000149","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926177978515625}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926177978515625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.37.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43.1"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.43","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211505889893}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211505889893}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306163787842}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.45","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306163787842}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000156","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.1"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.2"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4"},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.1"},"designation_date":{"value":"2022-11-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9892516136169434}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.2"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34"},"designation_date":{"value":"2023-04-20"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000160","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296717643737793}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.30"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.751910209655762}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.39"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.072850227355957}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32.1"},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.578298091888428}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05231"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000163","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"FW.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.094683647155762}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1"},"designation_date":{"value":"2023-05-01"},"frameShifts":{"value":"ORF6:3-62"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000165","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}},{"name":"FW.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"designation_date":{"value":"2023-08-22"},"frameShifts":{"value":"ORF6:3-62"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.714374542236328}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547362804412842}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.98364782333374}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000169","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000170","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7388600000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296717643737793}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.080835342407227}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.2"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.35"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.46"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.2145609855651855}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000173","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05408"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000174","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.77537202835083}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"NODE_0000179","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"HE.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65784"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.2"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1099290580037755"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6066099999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65784"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000183","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JW.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000185","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.68441104888916}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000186","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"internal_b1afb4e5","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.43418"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.2"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"XBB.1.17","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000190","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.111379623413086}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.10","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"GA.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000191","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GA.10.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"designation_date":{"value":"2023-12-03"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","G13822A","A19307G","G22927T","T22928C","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["V119I","K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: V119I, K1947R; ORF9b: T95M; S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"GA.2.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80721"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","T6640C","C9857T","C10279T","A12235G","A22910G","G23222A","A25927T","C29002T"],"ORF1a":["M85-"],"ORF3a":["I179F"],"S":["N450D","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF3a: I179F; S: N450D, E554K","spike_mutations":"N450D, E554K"}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GA.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000194","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.96117"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000195","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90647"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000196","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5"},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.110"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.110"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.22"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.23"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.43"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.543598651885986}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.45"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.57"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.463161468505859}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.58"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.87"},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.87"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93509"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873941659927368}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873941659927368}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2755987644195557}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.10"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.101"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.101"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.104"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.104"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.082747936248779}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.105"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.105"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.109"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.109"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.108"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.108"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.12"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.64321231842041}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.11"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.960800886154175}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.18"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7349727153778076}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.2"},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.002401351928711}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.28"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8485686779022217}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.29"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41404999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.31"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.887559652328491}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.34"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.28225564956665}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.35"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.06293249130249}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.33"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.639432191848755}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.36"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.254280090332031}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.40"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95377"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.198355674743652}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.52"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8478691577911377}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.51"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.54"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.59"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.106780052185059}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.63"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7503247261047363}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.64"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.169807434082031}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.62"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.189828872680664}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.66"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.67"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.767808198928833}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.69"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266829013824463}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.75"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.79"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.656114101409912}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.80"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.80"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.27465295791626}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.82"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.82"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.91194"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.85"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.85"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.914321422576904}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.97"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.97"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.99"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.99"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.98"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.98"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000202","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.174045562744141}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14"},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762266635894775}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.809102535247803}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762266635894775}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1023732112409157"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29094"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41123000000000004"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.282759666442871}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.728201150894165}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85055685043335}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3"},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.728201150894165}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456169128418}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456169128418}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994797945022583}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"designation_date":{"value":"2024-01-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994797945022583}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.50"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.71"},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48403999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"GC.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.03073601411565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9061"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.989251613616943}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.297218322753906}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.297218322753906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.091250896453857}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7416800000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.73864"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.285966396331787}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.285966396331787}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.830754280090332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.99921178817749}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}},{"name":"HS.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.830754280090332}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020680904388428}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1186099999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5119218826293945}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020680904388428}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}},{"name":"FZ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}},{"name":"HZ.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.319439888000488}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}},{"name":"HC.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576805830001831}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0346353162114479"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9873000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.174569606781006}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576805830001831}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.26"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054046630859}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054046630859}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3490142822265625}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.842705249786377}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"GN.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3490142822265625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889133453369}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889133453369}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{}}},{"name":"KK.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2868306565498102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.20635"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"KK.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}}]},{"name":"NODE_0000244","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376293182373}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3046787170970133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1261900000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.11","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.10","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70"},"designation_date":{"value":"2023-05-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GK.5.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"GK.3.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.486576080322266}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"NODE_0000251","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136261463165283}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136261463165283}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}},{"name":"GK.1.11","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.6.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}},{"name":"GK.1.8","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000259","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":51,"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3541583181563797"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446400000000003"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.4131407737731934}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.106"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.106"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.19"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062247276306152}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.20"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6764075756073}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.25"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.187679290771484}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.27"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.515899181365967}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.32"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6741185188293457}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.37"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5378670692443848}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.5"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0984206199646}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.56"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.201076507568359}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.6"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.60"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.624792098999023}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.61"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265188694000244}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.65"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8305227756500244}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.72"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7908682823181152}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.74"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0169257119491577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9630099999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.76"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.102418422698975}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.8"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.449068546295166}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.78"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.81"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.81"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.6281256675720215}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.83"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.83"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.545153617858887}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.84"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.84"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2501959800720215}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.88"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.88"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.298462390899658}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.9"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.89"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.89"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.91"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.91"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.224147319793701}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.90"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.90"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.96"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.96"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.111899375915527}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.94"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.94"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.447929859161377}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"NODE_0000263","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.83085"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0655517578125}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689449310303}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.135179042816162}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689449310303}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000266","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9838451476656441"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.83156"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237003326416}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9350799999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237003326416}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000271","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8168466091156006}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.310755729675293}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8168466091156006}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.5945"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.5945"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]},{"name":"NODE_0000274","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.124101638793945}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}},{"name":"FT.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0924169334128189"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74638"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89299"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}},{"name":"FD.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"NODE_0000283","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038018703460693}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}},{"name":"FD.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038018703460693}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.754912853240967}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.25"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.5613484382629395}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.26"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.335569381713867}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.2106804847717285}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.2106804847717285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.3"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.79517126083374}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.79517126083374}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.950188045949472"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86018"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9788766097021935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.67693"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"NODE_0000288","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652244567871}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652244567871}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388861179351807}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}},{"name":"FY.6.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8926499999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}},{"name":"FY.8.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80106"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80106"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"internal_77ad61e0","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"designation_date":{"value":"2023-09-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"FY.5.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3639702796936035}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3639702796936035}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}},{"name":"FY.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000304","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"NODE_0000305","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.9962849617004395}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16"},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.9962849617004395}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.10","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.10"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.275190353393555}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.12"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.11"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.181058406829834}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.14"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7388600000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.17"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.19"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.18"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.089405059814453}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.16"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.20"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.22"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.21"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.24"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.23"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.26"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1827216148376465}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.25"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.27"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.28"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.4"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.5"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.7"},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.9"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.8"},"designation_date":{"value":"2023-05-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"NODE_0000307","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"KJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.64385"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.64385"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.29"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.30"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.31"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.640304088592529}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"HF.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121833324432373}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8289546966552734}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000315","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}},{"name":"JF.1.1.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.412325859069824}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.5","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"FU.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.14642"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.412325859069824}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000319","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}},{"name":"FU.1.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.968926429748535}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8164899999999998"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.5","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"GY.7","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.968926429748535}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"GY.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.09678840637207}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.23"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.1"},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1416096687316895}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.42","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000327","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191345691680908}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.941244125366211}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191345691680908}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.4"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.5"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.6"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13558"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.7"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000329","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036271572113037}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.331241607666016}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036271572113037}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927202224731445}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.12","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.064052581787109}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.11","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.14","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.2342681884765625}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.532744884490967}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.27","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.29","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7904599999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.217490196228027}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.6","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.7","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927202224731445}},"branch_attrs":{"mutations":{}}},{"name":"internal_d2a6176a","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.459027290344238}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9957660361777405"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0848"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}},{"name":"FL.26","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.459027290344238}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90046"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90046"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"NODE_0000336","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431282043457}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431282043457}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.516284465789795}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.887217044830322}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.919838905334473}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.35","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.887217044830322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.1391448974609375}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.1391448974609375}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747514724731445}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}},{"name":"FL.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747514724731445}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.97144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.17","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}}]},{"name":"NODE_0000342","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299052715301514}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299052715301514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.398621082305908}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.20.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5920999999999998"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}}]},{"name":"internal_10251222","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342810153961182}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1216394663867173"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.98073"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342810153961182}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.3","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000347","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8835"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"FL.23.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.96117"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.066182613372803}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}},{"name":"FL.3.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282451629638672}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282451629638672}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_566a3ed0","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_69bba568","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376365661621}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376365661621}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":35},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07635999999999983"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}},{"name":"FL.13.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.67327356338501}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"designation_date":{"value":"2023-05-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000356","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1684T","C11747T","C29236T"]}}},{"name":"FL.15.4","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}}}]},{"name":"NODE_0000358","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G6819A","G22927T"],"ORF1a":["T2007I","S2185N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I, S2185N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000359","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]},{"name":"NODE_0000361","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.463090896606445}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.671279430389404}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8957390785217285}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"FL.2.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.854552745819092}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.2.7","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_95ea4775","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4.10","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.888331413269043}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.11","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.458424091339111}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93509"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.9","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"FL.4.7","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.97144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"internal_12061207","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0186868047371063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3348299999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000368","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"NODE_0000369","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}},{"name":"FL.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.854552745819092}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9778643306477401"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89211"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000372","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000373","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"designation_date":{"value":"2023-08-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.06800999999999986"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000374","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000375","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.36653995513916}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000376","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000377","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3005141566416802"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0007299999999998658"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000378","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232714653015137}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000379","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254451751709}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254451751709}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]},{"name":"NODE_0000380","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"HN.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000381","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.61879825592041}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.13","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.12","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.14","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.7","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1186099999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.61879825592041}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17686"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}},{"name":"EG.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.20938"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17686"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616470336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000384","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1256300000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}},{"name":"EG.10.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1256300000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919017791748}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919017791748}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000386","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8845162391662598}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8845162391662598}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"designation_date":{"value":"2023-09-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07635999999999983"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000387","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.092266082763672}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.092266082763672}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EG.4.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000390","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541389226913452}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541389226913452}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.121776580810547}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.5","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.570929050445557}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}},{"name":"EG.1.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173191070557}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000393","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"NODE_0000394","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0384697914123535}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.64849853515625}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000395","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747878074645996}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747878074645996}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.772064208984375}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.292908191680908}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.374487400054932}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621211528778076}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.585853576660156}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000399","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"designation_date":{"value":"2023-11-29"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4312755323086508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.73257"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000400","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000401","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.504891872406006}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.471978664398193}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000403","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.9912302494049072}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.3","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8333635330200195}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3.4","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000404","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735766887664795}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735766887664795}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000405","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068490982055664}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068490982055664}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3341105633249508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0887599999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.10","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.025979999999999802"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8597540855407715}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.4","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.5","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.401525974273682}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.3","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3005451981781486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21974"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.8","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.7","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.9","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043656826019287}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.048559999999999943"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3552393372267753"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.38161000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.412596225738525}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000407","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000408","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":53,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000410","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1972306507819483"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13706999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.19","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.18","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.21","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.205901853206978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.1481699999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.310148541751831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.49366"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"designation_date":{"value":"2023-11-27"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.29","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.267586708068848}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.28","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.32","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.31","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.25141716003418}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.30","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.7","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2183176254438959"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.6088199999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000417","node_attrs":{"div":51,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3534097328298118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.48614000000000007"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000421","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.570084095001221}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HK.27.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.213572025299072}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.213572025299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000425","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.15","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.9","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.64849853515625}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"HK.8","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366167068481445}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3.10","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366167068481445}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.934603691101074}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.4","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.7","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.5","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.9","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.3123884201049805}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.16","node_attrs":{"div":1,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.16"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.231195449829102}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.15"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.830538272857666}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.19"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.504542827606201}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"partiallyAliased":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2791748046875}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87.1"},"designation_date":{"value":"2024-02-01"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":41},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6657453429914796"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8217399999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}},{"name":"BA.2.87","node_attrs":{"div":1,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2791748046875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.703927040100098}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3"},"designation_date":{"value":"2021-12-14"},"totalAminoacidSubstitutions":{"value":44},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.8266096115112305}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1"},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.807485044002533}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.9166173934936523}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.1350862979888916}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000435","node_attrs":{"div":63,"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8540998697280884}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8540998697280884}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000436","node_attrs":{"div":66,"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066323280334473}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066323280334473}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":83,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2"},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.5603076219558716}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E156-","F157-","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"B","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B"},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{}}},{"name":"A","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A"},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"A"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.945819139480591}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}}]}]}]}]}]}]},{"name":"NODE_0000438","node_attrs":{"div":1,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4824707508087158}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.1"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.958989143371582}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.11"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.020416736602783}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.18"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.061755418777466}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.20"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9340524673461914}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.24"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.01261797446067892"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0435516834259033}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.27","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.27"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9488906860351562}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.28","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.28"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.955256462097168}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.29"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.246367931365967}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.26","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.26"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5775980949401855}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.32","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.32"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7237727642059326}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.30","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.30"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.182343006134033}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.39","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.39"},"designation_date":{"value":"2022-05-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.341081619262695}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.41","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.41"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7299158573150635}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.43","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.43"},"designation_date":{"value":"2022-05-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11284999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.410249710083008}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.4","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.4"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7205681800842285}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.42","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.42"},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.5","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.5"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.587897777557373}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.46"},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.784327030181885}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.48","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.48"},"designation_date":{"value":"2022-06-01"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.789991855621338}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.50"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.21274471282959}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.55"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.215762615203857}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.59","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.59"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.600702285766602}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.54","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.54"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.1376729011535645}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.58"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.052984714508057}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.61","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.61"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.49704647064209}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.62"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.998417377471924}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.63","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.63"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172097206115723}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.64","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.64"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5229692459106445}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.60","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.60"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.65","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.65"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8462483882904053}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.70","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.70"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.472927093505859}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.77"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3221048136122174"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9213199999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.581743240356445}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.82","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.82"},"designation_date":{"value":"2022-08-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.82"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.2169976234436035}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.8","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.8"},"designation_date":{"value":"2022-03-28"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3260767459869385}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.83"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.22071783986880583"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.83"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.12534"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.85"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.85"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.299956321716309}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000439","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565171957015991}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565171957015991}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2.1"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000440","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1333484649658203}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1333484649658203}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23.1"},"designation_date":{"value":"2022-05-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8213231563568115}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.867221832275391}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.31","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8213231563568115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000442","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8927619457244873}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.35","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.35"},"designation_date":{"value":"2022-04-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.570833206176758}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.33","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.33"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086804389953613}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797025442123413}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797025442123413}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40.1"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7479588985443115}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000444","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9644880294799805}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56"},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9644880294799805}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56.1"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.697122097015381}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"BA.2.10_internal","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636719226837158}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636719226837158}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.2"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.685617685317993}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.3"},"designation_date":{"value":"2022-05-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.080300331115723}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.4"},"designation_date":{"value":"2022-08-09"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3166622371297313"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.73328"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.095381259918213}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.472888946533203}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1"},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.472888946533203}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1.1"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6181860283242497"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.09519000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000447","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.6233313083648682}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.14"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.639008045196533}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.22"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2793376445770264}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.36"},"designation_date":{"value":"2022-05-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.069880962371826}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.34","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.34"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.04110860824585}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.45","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.45"},"designation_date":{"value":"2022-05-23"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.638923168182373}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.49","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.49"},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7811052799224854}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.47","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.47"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.130137920379639}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.52","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.52"},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8808929920196533}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.51","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.51"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6952691078186035}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.53","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.53"},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.6","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.6"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6632723808288574}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.69"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9400291442871094}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.71","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.71"},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.660404682159424}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.7","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.7"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.356358766555786}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.72","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.72"},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6165003776550293}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.80"},"designation_date":{"value":"2022-07-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.31190394480802347"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.80"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10838000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6450419425964355}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.81"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.81"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.347171783447266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.490032196044922}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.490032196044922}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25.1"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.996252536773682}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.739166498184204}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.44"},"designation_date":{"value":"2022-05-21"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11284999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.218892574310303}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5540249347686768}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13.1","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13.1"},"designation_date":{"value":"2022-07-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.024052619934082}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}},{"name":"BA.2.13","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13"},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5540249347686768}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.19162917137146}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.19162917137146}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.2"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6204254627227783}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.4"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.5"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.238983154296875}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.1","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.1"},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.3"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.352891683578491}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.7"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.828467607498169}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.6"},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.504576683044434}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}}]}]},{"name":"BA.2.3_internal","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485034465789795}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.10","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.10"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.098453044891357}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485034465789795}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.1"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.11"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797952890396118}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.13"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.348180055618286}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.14"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9584250450134277}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.17"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.899256467819214}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.15"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8729326725006104}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.12"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.18"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.462869644165039}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.19"},"designation_date":{"value":"2022-07-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.702392578125}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.5"},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.302077293395996}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.4"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.8"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.9"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8521361351013184}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.7"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020241260528564}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"internal_305a","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43687237373984505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9456899999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601465225219727}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06758"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.848114013671875}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4733677107846063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"DD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9683399999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000455","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.171501159667969}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.22"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.42289430257523936"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.37526000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.6"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.009505271911621}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9327023029327393}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2"},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9327023029327393}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000457","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4975483601650658"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66821"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}},{"name":"BS.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1"},"designation_date":{"value":"2022-09-12"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.49181526572268314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66194"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"designation_date":{"value":"2022-09-30"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6029918987948071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6589000000000002"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_a315","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666072845459}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666072845459}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.10"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7593324873420084"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8190299999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000459","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7016283989012374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.91683"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"CM.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8143059671640498"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9440299999999998"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}},{"name":"CM.6","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_7ac4","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7255583352017505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.99403"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000463","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000464","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000465","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0761544902802131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"FV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.28625999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.12"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.11"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0179803928276123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35566999999999993"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.9"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"CM.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000468","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287181854248}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000469","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9785485534494837"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9729599999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.128720760345459}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.17"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.112698078155518}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.21"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9177675247192383}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.37"},"designation_date":{"value":"2022-05-03"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1007766723632812}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.57"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.16643762588501}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.68","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.68"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.936066150665283}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.66","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.66"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.675917148590088}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.74","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.74"},"designation_date":{"value":"2022-06-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.33134042675697756"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21698000000000003"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.888683795928955}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.73","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.73"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.040534496307373}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.78","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.78"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.664737701416016}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000471","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0960655212402344}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.67"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000472","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79.1"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000473","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6619465351104736}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76"},"designation_date":{"value":"2022-07-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6619465351104736}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000474","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.1"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.2640232066165751"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18492"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}},{"name":"BA.2.76.2","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.2"},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.444322347640991}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38"},"designation_date":{"value":"2022-05-06"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.444322347640991}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"partiallyAliased":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.7409892082214355}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3"},"designation_date":{"value":"2022-08-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.07383293656037815"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.08445999999999997"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.7409892082214355}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3.1"},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.370455061085298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.580890655517578}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000477","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9894256591796875}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.1"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086116313934326}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000478","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.909890174865723}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.2"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.319439888000488}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.4"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.4497761726379395}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7863521575927734}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7863521575927734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.2"},"designation_date":{"value":"2022-06-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.062348652344665065"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07350000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9584996700286865}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.057555675506592}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.057555675506592}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000481","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292704820632935}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.1"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.2"},"designation_date":{"value":"2022-06-18"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0345394611358643}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.4","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.6","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.6"},"designation_date":{"value":"2022-08-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}},{"name":"BG.5","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.5"},"designation_date":{"value":"2022-07-28"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.7","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.7"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.3","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.862102746963501}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.862102746963501}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.10"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.499692916870117}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.7"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.544760227203369}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.8"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04854"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81858"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.514627456665039}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13451"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000485","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7472099999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7472099999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.37898588180542}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.3"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5588825437629772"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.24593"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000487","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9449499999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9449499999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7451886007636047"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.12575999999999996"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000488","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.4"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5013910005227346"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.10514"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000489","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5"},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03573"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03573"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}}]}]}]}]},{"name":"NODE_0000490","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100636959075928}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100636959075928}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.4"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000491","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210721492767334}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.5"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.16854"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"BL.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.3"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"NODE_0000492","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590966701507568}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.043233394622803}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}},{"name":"BL.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590966701507568}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000493","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.178379535675049}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.178379535675049}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.19193"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.3464399999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6011952983295785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.56756"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.973597526550293}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.1.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.6"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5544855553668998"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.11979"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.6811747550964355}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.6811747550964355}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275516986846924}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275516986846924}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_147e","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41646999999999995"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263591289520264}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2"},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263591289520264}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41646999999999995"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.716527938842773}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.4","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.4"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.6"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"CA.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.7"},"designation_date":{"value":"2022-10-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.5"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2371799999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.580175399780273}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}},{"name":"CA.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000500","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096987247467041}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096987247467041}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.4"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14197"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.784380912780762}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.6"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.5"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227935791015625}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227935791015625}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14197"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488797664642334}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5060716304521155"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.11385"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488797664642334}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.653690335850791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.9134323596954346}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}}]},{"name":"NODE_0000503","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420084476470947}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420084476470947}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.11","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.977697372436523}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.8","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9193315170816834"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5340599999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.7","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"NODE_0000504","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.2021600000000001"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.2021600000000001"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000505","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842318534851074}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7815531080803261"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.31233"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}},{"name":"BN.1.5.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7470314258752732"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1331"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]}]},{"name":"NODE_0000507","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000508","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735761642456055}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.108586311340332}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}},{"name":"BN.1.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.1361188888549805}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"designation_date":{"value":"2022-11-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.22015380859375}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000510","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.501852035522461}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.501852035522461}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.775949239730835}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7326886306518271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.21326"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.376982688903809}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"NODE_0000511","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000512","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000513","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}},{"name":"FR.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}}]}]}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563655376434326}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563655376434326}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4979681968688965}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.060053825378418}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0513083167390975"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.16291"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}},{"name":"DS.3","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.12","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.114459037780762}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"designation_date":{"value":"2023-03-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.856032848358154}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.576071739196777}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.082351207733154}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.3","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"designation_date":{"value":"2023-08-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"designation_date":{"value":"2023-02-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.791740894317627}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.041548728942871}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000520","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307618141174316}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307618141174316}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.3"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301943778991699}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.6","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.6"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15852"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"BM.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.5"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15852"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.031525135040283}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000521","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.052262306213379}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.052262306213379}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5272935807019111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.26994"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.548510551452637}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78817"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.174620628356934}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}},{"name":"BM.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81858"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.425735950469971}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1"},"designation_date":{"value":"2022-08-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.425735950469971}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78306245803833}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78306245803833}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000525","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458258628845215}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}},{"name":"BM.1.1.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}}]},{"name":"NODE_0000526","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.028015613555908}},"branch_attrs":{"mutations":{"nuc":["C3130T","C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.028015613555908}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"designation_date":{"value":"2022-12-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000527","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","C3130T","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.46466000000000013"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000528","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.46466000000000013"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000529","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000530","node_attrs":{"div":39,"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]},{"name":"internal_f6c6","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.266562461853027}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.43724"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.266562461853027}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273096084594727}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273096084594727}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000533","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"designation_date":{"value":"2022-12-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9457248359372292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.87567"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.26216459274292}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000534","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}},{"name":"CJ.1.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539737701416016}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539737701416016}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628327369689941}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628327369689941}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506646633148193}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506646633148193}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000538","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852518558502197}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"CH.3.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0219999999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7685109779549473"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36891999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000541","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000542","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.21","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"designation_date":{"value":"2023-03-29"},"frameShifts":{"value":"ORF7a:59-122"},"totalAminoacidSubstitutions":{"value":69},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.9441222497200389"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.08511000000000003"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}},{"name":"CH.1.1.18","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}}]},{"name":"NODE_0000543","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000544","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9334899999999999"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}},{"name":"GQ.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9334899999999999"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000545","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.328583240509033}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8057045936584473}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0050458908081055}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"internal_ddb1","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000547","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363282680511475}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363282680511475}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000554","node_attrs":{"div":40,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000555","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000558","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000559","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000560","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000561","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000562","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000563","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462226867676}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"designation_date":{"value":"2023-01-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000564","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000565","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000566","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000567","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"designation_date":{"value":"2023-09-24"},"frameShifts":{"value":"ORF7a:62-122"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:62-122"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000569","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"designation_date":{"value":"2023-03-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000571","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000573","node_attrs":{"div":37,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.3224663734436035}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"designation_date":{"value":"2023-04-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.3224663734436035}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9815994835819151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.16085999999999998"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000576","node_attrs":{"div":43,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000577","node_attrs":{"div":50,"partiallyAliased":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.661655902862549}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86"},"designation_date":{"value":"2023-08-17"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.661655902862549}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.5"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"NODE_0000578","node_attrs":{"div":52,"partiallyAliased":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}},{"name":"LV.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.2"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}}]},{"name":"NODE_0000579","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7"},"designation_date":{"value":"2024-06-13"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000580","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.6738025507980547"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000581","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.1"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000582","node_attrs":{"div":56,"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2"},"designation_date":{"value":"2024-03-05"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15919"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000583","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"designation_date":{"value":"2024-03-20"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000584","node_attrs":{"div":52,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.782770156860352}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.4"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.518976211547852}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000585","node_attrs":{"div":53,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.8259432315826416}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1"},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.8259432315826416}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.12"},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.14","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.14"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.16","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.16"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.17","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.17"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.15","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.15"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.18","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.18"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.01167631149292}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.19","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.19"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.808485507965088}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.6"},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.8","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.8"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.7","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.7"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.9"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"NODE_0000586","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11"},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000587","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13"},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000588","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5"},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6465599999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000589","node_attrs":{"div":55,"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.34682559967041}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.34682559967041}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000590","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"ORF1a":["P892S"]},"labels":{"aa":"N: H300Y; ORF1a: P892S"}},"children":[{"name":"JN.3.2","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]}]},{"name":"internal_59b29264","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.4","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.5","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000592","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000593","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.369624137878418}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.10"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.50243616104126}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000594","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7884089946746826}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1"},"designation_date":{"value":"2023-09-29"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7884089946746826}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.408935546875}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26806999999999986"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217947959899902}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9045872688293457}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062774658203125}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.875373840332031}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.674196720123291}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.493675231933594}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491053104400635}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407819747924805}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.03013801574707}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.296980381011963}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.23248815536499}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.804255247116089}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.117530822753906}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.341228008270264}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.62","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"designation_date":{"value":"2024-06-08"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.61","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.496607246855186"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93036"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407478332519531}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.66","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086578369140625}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.971951007843018}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086578369140625}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240832328796387}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"designation_date":{"value":"2024-02-20"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.21099"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240832328796387}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.23.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.21099"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012979507446289}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3227739334106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012979507446289}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.162879467010498}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.261645793914795}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"JN.1.32","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.162879467010498}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844123840332031}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844123840332031}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.38.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.390693187713623}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}},{"name":"JN.1.43","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.390693187713623}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741860389709473}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.848097324371338}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.44","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741860389709473}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.473700046539307}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.473700046539307}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.532734695870142"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.05681999999999991"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906609058380127}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5395016697354735"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7602899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906609058380127}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2344651222229}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2344651222229}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.492700099945068}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803304672241211}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803304672241211}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":8.507},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"NODE_0000606","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1652140617370605}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1652140617370605}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7444634437561035}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.048468589782715}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.048468589782715}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250581741333008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250581741333008}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395020484924316}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395020484924316}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341370105743408}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341370105743408}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"designation_date":{"value":"2024-07-10"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4552719593048096}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.33223295211792}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.33223295211792}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.063129425048828}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005730152130127}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.993558406829834}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005730152130127}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4039130210876465}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4039130210876465}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.081502914428711}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.081502914428711}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.51407527923584}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.51407527923584}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.771152973175049}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.627852916717529}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}},{"name":"JN.1.55.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}}]}]},{"name":"NODE_0000618","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.6971025466918945}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.6971025466918945}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000619","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.189657688140869}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.189657688140869}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.898664951324463}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.853456020355225}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"JN.1.39","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.898664951324463}},"branch_attrs":{"mutations":{}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1753339767456055}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.563376426696777}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655728340148926}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"designation_date":{"value":"2024-04-02"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.302780628204346}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"JN.1.42","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"designation_date":{"value":"2024-03-25"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655728340148926}},"branch_attrs":{"mutations":{}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"designation_date":{"value":"2024-05-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"designation_date":{"value":"2024-08-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"designation_date":{"value":"2024-05-18"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"ME.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.27215999999999985"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.891266345977783}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.891266345977783}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834461688995361}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834461688995361}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000628","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2595099999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343695163726807}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343695163726807}},"branch_attrs":{"mutations":{}}},{"name":"internal_dafb7842","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5484747886657715}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5484747886657715}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693490982055664}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.124732494354248}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688722133636475}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566845893859863}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.104548454284668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"NODE_0000637","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000639","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.500879287719727}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.500879287719727}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000640","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438821315765381}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.6234025955200195}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000641","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617192268371582}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617192268371582}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.780251502990723}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.780251502990723}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424532413482666}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424532413482666}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753118515014648}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.045562267303467}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"designation_date":{"value":"2024-08-20"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.396651744842529}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000647","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.625002384185791}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.625002384185791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000648","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000649","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3745641202332524"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9318500000000001"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000650","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"designation_date":{"value":"2024-04-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000651","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772459506988525}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.320776462554932}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772459506988525}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.515129089355469}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000655","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.30217999999999995"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000657","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.307804584503174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.224503517150879}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.58","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.307804584503174}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.408945083618164}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872630596160889}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872630596160889}},"branch_attrs":{"mutations":{}}},{"name":"LR.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}},{"name":"LR.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4686198234558105}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.532440185546875}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.532440185546875}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.34312105178833}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.34312105178833}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.9152421951293945}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.9152421951293945}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.229276180267334}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005531311035156}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.02389"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.469202041625977}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.105811595916748}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.09798002243042}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309722900390625}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309722900390625}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.690683841705322}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.175650596618652}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08313"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.566635608673096}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000671","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000672","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347302436828613}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347302436828613}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04395"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.99325704574585}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95433"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.99325704574585}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.711982011795044}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.776760578155518}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.711982011795044}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.743708610534668}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924505710601807}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924505710601807}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000677","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.816462993621826}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0927324295043945}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.036890506744385}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"designation_date":{"value":"2024-02-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685323238372803}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685323238372803}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782630443572998}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782630443572998}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.02389"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000681","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769372940063477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769372940063477}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145790100097656}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000682","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}},{"name":"LE.1.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5281498432159424}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5281498432159424}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000684","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642734527587891}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642734527587891}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3354692459106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972527980804443}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972527980804443}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69521951675415}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}},{"name":"KZ.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69521951675415}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000689","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227226734161377}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.8855462074279785}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.850363254547119}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000690","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000691","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":11.111},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2408299999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000692","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.3","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}},{"name":"KR.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}}]}]}]}]},{"name":"NODE_0000693","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056233882904053}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056233882904053}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.607518196105957}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145547866821289}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145547866821289}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000695","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9964990615844727}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"designation_date":{"value":"2024-04-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9964990615844727}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.6","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69572114944458}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.8","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.729191780090332}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2408299999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000696","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558164119720459}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"designation_date":{"value":"2024-08-24"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}},{"name":"LB.1.4.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558164119720459}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000697","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624444961547852}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.662596225738525}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624444961547852}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}},{"name":"LB.1.7.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}}]},{"name":"NODE_0000699","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111886501312256}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111886501312256}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438388347625732}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.472174167633057}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.925361394882202}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.925361394882202}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347464084625244}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415004730224609}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415004730224609}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.04741999999999978"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000704","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.689547538757324}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005441188812256}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"NODE_0000706","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.083190441131592}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.083190441131592}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.09660530090332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.7","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":50.174},"immune_escape":{"value":"1.817229820305529"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21767999999999987"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"LF.6","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.9","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.557812213897705}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.290716171264648}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.290716171264648}},"branch_attrs":{"mutations":{}}},{"name":"LF.4.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}}]},{"name":"NODE_0000708","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693272590637207}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C28660T"],"S":["T33A"]},"labels":{"aa":"S: T33A","spike_mutations":"T33A"}}},{"name":"LF.9.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5064377784729}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"designation_date":{"value":"2024-05-28"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"designation_date":{"value":"2024-06-29"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"designation_date":{"value":"2024-06-04"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000713","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000714","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}},{"name":"LF.8.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.106093406677246}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.106093406677246}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9550347328186035}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9550347328186035}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688606262207031}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688606262207031}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.221215724945068}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.829525470733643}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.829525470733643}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.795657634735107}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":11.111},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3926199999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.450676441192627}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.450676441192627}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.520935535430908}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.721512317657471}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"NODE_0000724","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.106141090393066}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"NODE_0000726","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.159374713897705}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.159374713897705}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7445478439331055}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000727","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"NODE_0000728","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G"],"ORF1a":["K1226E"]},"labels":{"aa":"ORF1a: K1226E"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}},{"name":"LZ.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"designation_date":{"value":"2024-08-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]},{"name":"internal_24bd909c","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.753526210784912}},"branch_attrs":{"mutations":{"nuc":["C22928T"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.753526210784912}},"branch_attrs":{"mutations":{"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"internal_41eb7227","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"]},"labels":{"aa":"N: A152T; ORF1a: I740V"}},"children":[{"name":"LZ.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]}]}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858033657073975}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858033657073975}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.04741999999999978"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.008905410766602}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.3277153968811035}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.3277153968811035}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000734","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206735610961914}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7741516492587035"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.27333999999999997"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"KP.4.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{}}},{"name":"internal_7da46150","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000738","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679376125335693}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"designation_date":{"value":"2024-02-22"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679376125335693}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.903770923614502}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064724922180176}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064724922180176}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000743","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"internal_bfd296bd","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785137176514}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.9018449783325195}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000745","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013365268707275}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013365268707275}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.616637229919434}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.12","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.10","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.455721378326416}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.14","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.764108657836914}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.096656322479248}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.764108657836914}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"internal_1e4c8e87","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.2861931324005127}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7908990401504723"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000750","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000751","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.9161720275878906}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21942999999999988"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.532754421234131}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.17","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.18","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.5323338508605957}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.7","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206735610961914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.2.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.6","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.883235454559326}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}}]}]},{"name":"NODE_0000752","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987194061279297}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987194061279297}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519747734069824}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519747734069824}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5554650921238282"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15242"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"NODE_0000755","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125619888305664}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"designation_date":{"value":"2024-06-09"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.35004997253418}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":70,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.607268810272217}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.607268810272217}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000761","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000763","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7206397516519647"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.11924"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000765","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.12","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.857026100158691}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.10","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.15","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.14","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.4","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.8321967124938965}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.3","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.6","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.7","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5369762101413171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000767","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787517547607}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787517547607}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.619511127471924}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000771","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.494636058807373}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.8"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.494636058807373}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325202703475952}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325202703475952}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.2"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000773","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.914329767227173}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.5","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.5"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.328583240509033}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.3","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.622591733932495}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.7","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.7"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000774","node_attrs":{"div":10,"partiallyAliased":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.785727024078369}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.785727024078369}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.1"},"designation_date":{"value":"2022-09-05"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.2","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.4"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.3"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.71883"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"NODE_0000775","node_attrs":{"div":11,"partiallyAliased":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"DC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66094"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000776","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947989463806152}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1.1","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.1"},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1"},"designation_date":{"value":"2022-05-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947989463806152}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.5"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.291128635406494}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.100764274597168}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.6"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.0240254402160645}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.9"},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.8"},"designation_date":{"value":"2022-07-29"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8587090969085693}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000777","node_attrs":{"div":8,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.2"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000778","node_attrs":{"div":9,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.11"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000779","node_attrs":{"div":11,"partiallyAliased":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5308081831240151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.67074"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7561969850799493"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"CS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5702799999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000780","node_attrs":{"div":12,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1984522342681885}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1984522342681885}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.9"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39901000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2395055294036865}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"NODE_0000781","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.000426292419434}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"ORF1a":["M2096L"]},"labels":{"aa":"ORF1a: M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.8"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3900210857391357}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000782","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.946847438812256}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.946847438812256}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.5.2","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.2"},"designation_date":{"value":"2022-08-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.243048667907715}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"NODE_0000783","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891695261001587}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.1"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5131304264068604}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.3"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.187767505645752}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0000784","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0763676166534424}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0763676166534424}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000785","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130263805389404}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.3"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.1"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.4","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.4"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5883099999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000786","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2"},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000787","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6570799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000788","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.391442775726318}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"designation_date":{"value":"2022-11-20"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000789","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2668371200561523}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"]}},"children":[{"name":"BA.5.1.11","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.11"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2668371200561523}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.16","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.16"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9540939331054688}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.12","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.12"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4273571968078613}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.14"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.965997695922852}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.17","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.17"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.774637222290039}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.2"},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.26383900642395}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.24"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3640353679656982}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.28"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.258055686950684}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.30","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.30"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9021799564361572}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.3","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1503868103027344}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.34","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.34"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.5"},"designation_date":{"value":"2022-07-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1470391750335693}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.4","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.4"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.6","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.6"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.541717290878296}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.8","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.8"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6331067085266113}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"BA.5.1.7","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.886288642883301}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"NODE_0000790","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3361656665802}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3361656665802}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10.1"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0975565910339355}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0975565910339355}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15.1"},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000792","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213085651397705}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213085651397705}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000793","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"NODE_0000794","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33.1"},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_35cd","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.303285837173462}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.31"},"designation_date":{"value":"2022-11-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.38"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198990821838379}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198990821838379}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_bae4","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8467977046966553}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8467977046966553}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1158230304718018}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.1"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}},{"name":"DE.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.2"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}}]}]},{"name":"NODE_0000799","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.430185079574585}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.18"},"designation_date":{"value":"2022-08-28"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7965612411499023}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000800","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069729328155518}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069729328155518}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.1"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.2"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8074238300323486}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8074238300323486}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.113799095153809}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.113799095153809}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000803","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.255287170410156}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"designation_date":{"value":"2022-12-10"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"designation_date":{"value":"2022-12-23"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000804","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}},{"name":"DJ.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5218353271484375}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.27"},"designation_date":{"value":"2022-09-30"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29"},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000807","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"CL.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.56931734085083}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0000809","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.73331618309021}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.083285093307495}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.19"},"designation_date":{"value":"2022-09-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047452926635742}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.32"},"designation_date":{"value":"2023-01-15"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.9"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.180713176727295}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000810","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.134702682495117}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.20"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.535201072692871}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.37","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.37"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}},{"name":"BA.5.1.36","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.36"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}}]}]}]},{"name":"NODE_0000811","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.151430368423462}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.11"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.79317307472229}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000813","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000814","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}},{"name":"DF.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1"},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7135770320892334}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2"},"designation_date":{"value":"2022-05-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7135770320892334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000816","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.681718111038208}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.681718111038208}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.12"},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5279"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.980180025100708}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.17","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.17"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.486154556274414}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.19","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.19"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.18"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092384338378906}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.30"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.33"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6034899999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.4"},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5524494647979736}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.6"},"designation_date":{"value":"2022-07-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.914687395095825}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.8"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4910664558410645}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000817","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.093046188354492}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BF.14","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.14"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.080418825149536}},"branch_attrs":{"mutations":{"nuc":["C16726T"],"ORF1b":["H1087Y"]},"labels":{"aa":"ORF1b: H1087Y"}}},{"name":"BF.35","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.35"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I"}}}]},{"name":"NODE_0000818","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278829097747803}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278829097747803}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006065368652344}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5959379308450252"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.33263"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.380862712860107}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006065368652344}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141825199127197}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141825199127197}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000821","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765230655670166}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11"},"designation_date":{"value":"2022-07-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765230655670166}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.462978363037109}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000822","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.166635990142822}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.292905807495117}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0000823","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7687714099884033}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.789764165878296}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.28"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2670040130615234}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.36","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.36"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8735761642456055}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.9"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4620237350463867}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000824","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318788051605225}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318788051605225}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000825","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1384167671203613}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"designation_date":{"value":"2022-12-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.563032084337257"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3218"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.989957332611084}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1384167671203613}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000826","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1209096908569336}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.15"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.382328033447266}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.20"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.54063081741333}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000827","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.864675521850586}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.21"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1568257808685303}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.27"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3812053203582764}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000828","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.4587268829345703}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.13"},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.16"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.369956970214844}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.22"},"designation_date":{"value":"2022-08-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.25"},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.29"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.740654468536377}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.34"},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685994625091553}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.23"},"designation_date":{"value":"2022-09-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74171257019043}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.324922561645508}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.324922561645508}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48889999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278613567352295}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000831","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6619062423706055}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.24"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000832","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160460948944092}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160460948944092}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000833","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7555084228515625}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.592723846435547}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000834","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2662811279296875}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000835","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.605587959289551}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8483927249908447}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000836","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"designation_date":{"value":"2023-02-08"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000837","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.604166269302368}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.42"},"designation_date":{"value":"2023-04-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.397212505340576}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.26"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.32"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.259809494018555}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.37"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.417162895202637}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.40"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.287785291671753}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238624095916748}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238624095916748}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0000840","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7"},"designation_date":{"value":"2022-07-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"designation_date":{"value":"2022-10-05"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.541252613067627}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.11","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.68569278717041}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5383851528167725}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.18","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.512576103210449}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.17","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6393200000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7448058128356934}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.21","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.22","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.24","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.23","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.26","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.8","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2593913078308105}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"BF.7.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7265231609344482}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"NODE_0000841","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}},{"name":"BF.7.16","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000842","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}},{"name":"BF.7.19","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000843","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000844","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6759999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000845","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"designation_date":{"value":"2023-03-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.398621082305908}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000846","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762614250183105}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3122613430023193}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0000847","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000848","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.4","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"designation_date":{"value":"2023-01-25"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0000849","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.6","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000850","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6321210861206055}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.23"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8151862621307373}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.40","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.40"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.4"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.182602405548096}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.5","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.5"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.9"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.992319345474243}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000851","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2575464248657227}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.10"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.743116855621338}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.628093719482422}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000852","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8561782836914062}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8561782836914062}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26.1"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.20828914642334}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]},{"name":"NODE_0000853","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190244674682617}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.22"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.498509168624878}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.29","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.29"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.531074047088623}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.28","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.28"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.239920139312744}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.45","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.45"},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5131699999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998836994171143}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.52"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.161771774291992}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.55"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.999176263809204}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.59"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.273857116699219}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0000854","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9824576377868652}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9824576377868652}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39901000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.402865409851074}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0000855","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680343151092529}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680343151092529}},"branch_attrs":{"mutations":{}}},{"name":"DZ.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.2"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"DZ.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.57471227645874}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}}]}]},{"name":"NODE_0000856","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190244674682617}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.12"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3988966941833496}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.13"},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.693641424179077}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.14"},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.19"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7941062450408936}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.30"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.567555904388428}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.35","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.35"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.34","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.34"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.511683702468872}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.39","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.39"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.37"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460197448730469}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.42","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.42"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.43"},"designation_date":{"value":"2022-11-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5413273873731987"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5642800000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.44"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.282501697540283}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.46"},"designation_date":{"value":"2022-12-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.53"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.239439964294434}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.54"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.244083404541016}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.58","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.58"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236837387084961}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.57"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7188966274261475}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.62"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.200337886810303}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.63"},"designation_date":{"value":"2023-02-14"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.61","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.61"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.7162909507751465}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.8","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.8"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9471049308776855}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.359752178192139}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.11"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.216500282287598}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.32"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36507511138916}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.812325954437256}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.812325954437256}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.800739765167236}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_1651","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.183877944946289}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.183877944946289}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7208595659836455"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4564899999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.672420024871826}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3631205558776855}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.30660604695253"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.56458"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3631205558776855}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6759999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.4745917320251465}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000861","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.41"},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.726137638092041}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.56"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.041235446929932}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329526901245117}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329526901245117}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47.1"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000863","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4698426723480225}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4698426723480225}},"branch_attrs":{"mutations":{}}},{"name":"CN.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.2"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}},{"name":"CN.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.1"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.227382183074951}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000864","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.852180004119873}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.2"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.280703544616699}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"internal_6217","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.214096546173096}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.185972690582275}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.185972690582275}},"branch_attrs":{"mutations":{}}},{"name":"CD.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3253063676642168"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5594199999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}},{"name":"CD.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.559537887573242}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}}]},{"name":"NODE_0000867","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064776420593262}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.50"},"designation_date":{"value":"2023-01-21"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74055290222168}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.51","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.51"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.903770923614502}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.60"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585160255432129}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000868","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.2"},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.1"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.679447650909424}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0000869","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.1"},"designation_date":{"value":"2022-09-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.205173015594482}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.3"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}},{"name":"BU.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415644645690918}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25"},"designation_date":{"value":"2022-09-25"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415644645690918}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.356500625610352}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.3"},"designation_date":{"value":"2023-02-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.2"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.673305034637451}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"internal_93c4","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.993558883666992}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"internal_f379","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665871620178223}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665871620178223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000874","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3630194664001465}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.244806289672852}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40216999999999997"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000875","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131978988647461}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48"},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131978988647461}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.705625534057617}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000876","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}},{"name":"DY.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000877","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.89189076423645}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2117154598236084}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2117154598236084}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.3"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.38661"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.831022262573242}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.2"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5295255377787571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6942999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.206465244293213}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.6","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.6"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.885945796966553}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.4","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.4"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.632347583770752}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.5"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.982746124267578}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.7"},"designation_date":{"value":"2023-03-02"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"internal_7ebe","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}},{"name":"CP.8","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000880","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4362287521362305}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1"},"designation_date":{"value":"2022-10-13"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4362287521362305}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6003199999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}},{"name":"CP.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"designation_date":{"value":"2022-10-13"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.384659290313721}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.319679260253906}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}}]}]},{"name":"NODE_0000881","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071225166320801}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24"},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071225166320801}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.3"},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2413458824157715}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.667097091674805}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.667097091674805}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.376063346862793}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.376063346862793}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000884","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0000885","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.083762168884277}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.083762168884277}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0000886","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.002089500427246}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.71883"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.712406158447266}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0000887","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.607504844665527}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0000888","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.022320747375488}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"designation_date":{"value":"2022-12-29"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.022320747375488}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.657641887664795}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000889","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.170691967010498}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"ORF1a":["Q556K"]},"labels":{"aa":"ORF1a: Q556K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3"},"designation_date":{"value":"2022-05-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.170691967010498}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.3"},"designation_date":{"value":"2022-06-24"},"frameShifts":{"value":"ORF7a:72-122"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782665967941284}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.5"},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.307540416717529}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000890","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8095927238464355}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.4","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.4"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2507734298706055}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}},{"name":"BA.5.3.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.2"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9211783409118652}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}}]},{"name":"NODE_0000891","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{}}},{"name":"BE.2","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.800240993499756}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T"],"ORF1a":["T882I"]},"labels":{"aa":"ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.3"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2200911045074463}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.5"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000892","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.511610984802246}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.10"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.9"},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6685283184051514}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000893","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.290349960327148}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","T28693C"],"ORF1a":["M85-"]},"labels":{"aa":"ORF1a: M85-"}},"children":[{"name":"BE.7","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.7"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.395103931427002}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}},{"name":"BE.6","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.6"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.737630844116211}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}}]},{"name":"NODE_0000894","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.721144437789917}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.11","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.11"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.008347511291504}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"BE.12","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.12"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"NODE_0000895","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2481184005737305}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.13"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5088823627149919"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5231200000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.8"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":94},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":1},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0000896","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245568752288818}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T"],"ORF1a":["T3308N"]},"labels":{"aa":"ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245568752288818}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000897","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2813496589660645}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000898","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000899","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40216999999999997"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9200546741485596}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000900","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000901","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0249316692352295}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"ORF1b":["M1156I"]},"labels":{"aa":"ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0249316692352295}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.957712173461914}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000902","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295792102813721}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295792102813721}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000903","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8224959014481948"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49383999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000904","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0000905","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367693901062012}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"internal_874c","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.770998001098633}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.770998001098633}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000907","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190595626831055}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190595626831055}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000908","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.037123680114746}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"designation_date":{"value":"2022-08-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.037123680114746}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5680790723509552"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45205000000000006"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.677981376647949}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000909","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.380139112472534}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.380139112472534}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3855838775634766}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4368526935577393}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7257362514460642"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6127800000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6570799999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8308113969466171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5446"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.457104206085205}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.424003601074219}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4287261962890625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9463791847229}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.914119720458984}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"designation_date":{"value":"2023-03-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.936223268508911}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4588372707366943}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.657702922821045}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000910","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761812686920166}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761812686920166}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"designation_date":{"value":"2023-01-26"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000911","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7374396324157715}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000912","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000913","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.866491794586182}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.866491794586182}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000914","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009603500366211}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.068519592285156}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176229476928711}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176229476928711}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000917","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710925579071045}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710925579071045}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"BQ.1.26.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}}]}]},{"name":"NODE_0000919","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4316978454589844}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0000921","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6853534127590314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6353800000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.400434494018555}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688451290130615}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688451290130615}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875689029693604}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"NODE_0000925","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9874397743924017"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66664"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000926","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"designation_date":{"value":"2023-04-28"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60833"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"designation_date":{"value":"2023-08-31"},"frameShifts":{"value":"ORF7a:83-122"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":31},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0821590912755812"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6059300000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]},{"name":"internal_dbfb","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6925976779449897"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5174000000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7586450576782227}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.16","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.18","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.5464019775390625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4521586894989014}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.057005405426025}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.637410640716553}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000931","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3929214477539062}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"designation_date":{"value":"2022-09-09"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3929214477539062}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8915650844573975}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.535731315612793}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"designation_date":{"value":"2022-11-03"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.149692535400391}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.225134372711182}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8728938682420008"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5921799999999998"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.841220855712891}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7449699999999998"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.07365083694458}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60833"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.833066940307617}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.314393520355225}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.201074600219727}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9046709537506104}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.704440116882324}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.068450927734375}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9954097270965576}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.249934673309326}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.386298179626465}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.861405372619629}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.360784530639648}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530673503875732}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.3784332275390625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9752700328826904}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.371273994445801}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9168782234191895}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276081085205078}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.05605936050415}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.841140031814575}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.636171340942383}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.239450931549072}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.051732686328446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.731185436248779}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000932","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955434799194336}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955434799194336}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"designation_date":{"value":"2022-12-07"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.65602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.960555553436279}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7361","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2028326988220215}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2028326988220215}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.70602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.662565231323242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000934","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0995001792907715}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"designation_date":{"value":"2022-10-19"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0995001792907715}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"designation_date":{"value":"2023-01-12"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.108586311340332}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000935","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9425103664398193}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.781043529510498}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"designation_date":{"value":"2022-12-02"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.53029203414917}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000936","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500977039337158}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674434661865}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674434661865}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ET.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.596988677978516}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ES.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000939","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8486416339874268}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8486416339874268}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"designation_date":{"value":"2022-11-30"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74371"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.994874000549316}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_bf35","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6950554847717285}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6950554847717285}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000941","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9105813557217661"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66913"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452545166015625}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452545166015625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9185686111450195}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000943","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9088191986083984}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9088191986083984}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.810015678405762}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{}}},{"name":"CZ.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.435018539428711}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"CZ.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6774299999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}}]},{"name":"NODE_0000945","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000946","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952062606811523}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952062606811523}},"branch_attrs":{"mutations":{}}},{"name":"ER.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"designation_date":{"value":"2023-03-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}}]}]},{"name":"NODE_0000947","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"DR.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-01-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.548947334289551}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}}]},{"name":"NODE_0000948","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694454669952393}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694454669952393}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000949","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"EN.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}}]}]},{"name":"NODE_0000950","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.648621082305908}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.49","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.766948223114014}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.48","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.3889336585998535}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{}}},{"name":"EA.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.880706782961692"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.34834999999999994"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.922172546386719}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}},{"name":"EA.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478137016296387}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504777431488037}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504777431488037}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918827056884766}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.8300909996032715}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.188085079193115}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.897580623626709}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000954","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1676859855651855}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000955","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.43596076965332}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.43596076965332}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002801895141602}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002801895141602}},"branch_attrs":{"mutations":{}}},{"name":"DT.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.224767684936523}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}},{"name":"DT.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.392630577087402}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.660925388336182}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.117684841156006}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302687644958496}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000959","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{}}},{"name":"EE.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131553649902344}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.184222221374512}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.522237300872803}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.840277671813965}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}}]},{"name":"NODE_0000961","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.25513219833374}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000962","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0000963","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"designation_date":{"value":"2023-04-17"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000964","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"designation_date":{"value":"2023-03-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24659999999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24659999999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]},{"name":"NODE_0000965","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"designation_date":{"value":"2023-01-24"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.65602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"NODE_0000966","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1417622566223145}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1417622566223145}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.072010040283203}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1802849769592285}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1802849769592285}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000968","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138624668121338}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"EF.1.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"internal_e491","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000970","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656734943389893}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656734943389893}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000971","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024628162384033}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024628162384033}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.699550151824951}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000972","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-7.3331193923950195}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"DN.3","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000973","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000974","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8771384492554943"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5626099999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8990816968865659"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.05606"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8744814686582322"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6722600000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLGRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGGGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGATGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTTTAATTGTTACTTTCCTTTACGATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["E31-","R32-","S33-"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF9b":["E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S"]},"labels":{"aa":"N: E31-, R32-, S33-; ORF1a: S3675-, G3676-, F3677-; ORF9b: E27-, N28-, A29-; S: L24-, P25-, P26-, A27S","clade":"Omicron","spike_mutations":"L24-, P25-, P26-, A27S"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2"},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.14300012588501}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAB","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAB"},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.431697368621826}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAA","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAA"},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAE","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAE"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAD","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAD"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.878465175628662}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAC","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAC"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAF"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAH","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAH"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.748097896575928}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAG","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAG"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.583486080169678}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAL","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAL"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAJ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAJ"},"designation_date":{"value":"2022-07-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.648314476013184}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAK","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAK"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3037714005953052"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAQ","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAQ"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAN","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAN"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081246376037598}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAM","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAM"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAP","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAP"},"designation_date":{"value":"2022-07-30"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.999915599822998}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAR","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAR"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.451335430145264}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAT","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAT"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.875851154327393}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAU","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAU"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.17326545715332}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAS","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAS"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.452675819396973}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":82,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAW"},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.274687314409391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E156-","F157-","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAV","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAV"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.7257537841796875}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAZ","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAZ"},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.731168270111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBA"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.29808642936638835"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBD"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBE"},"designation_date":{"value":"2022-10-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.574320316314697}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBG","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBG"},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBH"},"designation_date":{"value":"2022-11-16"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBM","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBM"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBN","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBN"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBP","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBP"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBR"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBS"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBT"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5037920175803539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBQ"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBY","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBY"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBW"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBV"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBZ","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBZ"},"designation_date":{"value":"2023-03-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBU","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBU"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCB"},"designation_date":{"value":"2023-04-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCA"},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XCC","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCC"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCD"},"designation_date":{"value":"2023-06-08"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCE"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCG"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCJ"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCL","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCL"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCK","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCK"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCM","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCM"},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCN"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCP","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCP"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCQ","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCQ"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCR","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCR"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCS","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCS"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCU","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCU"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCV"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCY","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCY"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCW","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCW"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XDB","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDB"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XCZ","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCZ"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XDC","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDC"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDE"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDF"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDH"},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDJ","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDJ"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDG"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDM","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDM"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDN","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDN"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDL","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDL"},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDS","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDS"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDU","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDU"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9475349114594978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDT"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDY","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDY"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDW"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XDZ","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDZ"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XE","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XE"},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEB","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEB"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEA","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEA"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2268340125514634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XED"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":17.361},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XED"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEF","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEF"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":34.028},"immune_escape":{"value":"1.7268345560655398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEG"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":950.694},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEE","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEE"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.013909339904785}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XG"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XJ","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XJ"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XH","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XH"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XL","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XL"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XK","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XK"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XM","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XM"},"designation_date":{"value":"2022-03-31"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.148608207702637}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XN","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XN"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.339982509613037}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XR","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XR"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XT","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XT"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.084201812744141}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XP","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XP"},"designation_date":{"value":"2022-04-01"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3616394203564539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.0015506744384766}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XQ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XQ"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.572240829467773}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XW","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XW"},"designation_date":{"value":"2022-05-12"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XV","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XV"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.536291122436523}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XU","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XU"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XZ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XZ"},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.089031219482422}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XY"},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"partiallyAliased":{"value":"XBK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"partiallyAliased":{"value":"XCH"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH.1"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9920809268951416}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"partiallyAliased":{"value":"XCT"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT.1"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"partiallyAliased":{"value":"XDA"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"partiallyAliased":{"value":"XEC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC.1"},"designation_date":{"value":"2024-08-14"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":29.34},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":34.028},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.1"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}},{"name":"XCF.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.2"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.1"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.2"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"partiallyAliased":{"value":"XDR"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"partiallyAliased":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.2"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}},{"name":"XDR.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.1"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.2"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.1"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"partiallyAliased":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.083851337432861}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.083851337432861}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49430513381958}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.2"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.3"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1974196434021}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"partiallyAliased":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.3"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.4"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.2"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"internal_63f4","node_attrs":{"div":37,"partiallyAliased":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.3"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"partiallyAliased":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"partiallyAliased":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.3"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.5"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XDK.4.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.6"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":61,"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"NODE_0000033","node_attrs":{"div":62,"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.10","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.10"},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.10"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.2943291664123535}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.9","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.9"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.9"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"partiallyAliased":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116386413574}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116386413574}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1.1"},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"partiallyAliased":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"partiallyAliased":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":53,"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY"},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":53,"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.3"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":56,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":57,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1506476402282715}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.997220516204834}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":58,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1506476402282715}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.697917461395264}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}},{"name":"XAY.2.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":60,"partiallyAliased":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.2"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":62,"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000046","node_attrs":{"div":63,"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":64,"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":65,"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.682617664337158}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.2","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}},{"name":"GL.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752889267417711"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.494446754455566}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"partiallyAliased":{"value":"XDV"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"partiallyAliased":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.10"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.11"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.3"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.5"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5359962252743784"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14808999999999992"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.4","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.4"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.8"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"partiallyAliased":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":6.25},"immune_escape":{"value":"1.8051577060608006"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26874999999999993"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}},{"name":"XDV.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000052","node_attrs":{"div":60,"partiallyAliased":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5422010449483097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20783000000000001"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]},{"name":"NODE_0000053","node_attrs":{"div":61,"partiallyAliased":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":68,"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC"},"designation_date":{"value":"2022-09-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":68,"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.2.1"},"designation_date":{"value":"2023-03-19"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.44507236664312827"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}},{"name":"XBC.2","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"XBC.2"},"designation_date":{"value":"2022-10-14"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"totalAminoacidSubstitutions":{"value":58},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}}]},{"name":"NODE_0000057","node_attrs":{"div":70,"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"XBC.1"},"designation_date":{"value":"2022-10-03"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"totalAminoacidSubstitutions":{"value":57},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.187767505645752}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":76,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.4"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":75,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.5"},"designation_date":{"value":"2023-02-26"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000059","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":78,"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":79,"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48837241784414276"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1.2"},"designation_date":{"value":"2023-06-10"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":76,"partiallyAliased":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":76,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7"},"designation_date":{"value":"2023-06-10"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7.1"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7.2"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":79,"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.1","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.2"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.3","node_attrs":{"div":81,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.3"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":83,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.4"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":84,"partiallyAliased":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":84,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6"},"designation_date":{"value":"2023-03-16"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.2"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":87,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.4"},"designation_date":{"value":"2023-06-14"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":88,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.5"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":85,"partiallyAliased":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":88,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.1.1"},"designation_date":{"value":"2023-06-14"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.1"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":87,"partiallyAliased":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":89,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.6.1"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7550301657183831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"JT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":87,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.6"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":86,"partiallyAliased":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":86,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":89,"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.2","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1"},"designation_date":{"value":"2023-08-02"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}},{"name":"HW.1.1","node_attrs":{"div":92,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"designation_date":{"value":"2023-08-02"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420325830319254"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.9"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0810114368008295"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26627999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}},{"name":"XBB.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3064099999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000075","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.7"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000077","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000078","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.1"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.2"},"designation_date":{"value":"2023-06-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000079","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.2"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.4"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.5"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000080","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.3"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}},{"name":"XBB.3.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122062683105469}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122062683105469}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.12"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.4"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.165234565734863}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.9"},"designation_date":{"value":"2023-05-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54503870010376}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.8"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.256869792938232}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"internal_619ad3bd","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143047332764}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143047332764}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11.1"},"designation_date":{"value":"2023-06-11"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65097"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000084","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.83268404006958}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.10"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000085","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.1"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.2"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000086","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.2"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.3"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.6","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000087","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067752838134766}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35217"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35217"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067752838134766}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000088","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.583855628967285}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.14"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.900240898132324}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.18"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2567103717994188"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0750199999999999"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.20"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.21"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.22"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.5"},"designation_date":{"value":"2023-04-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84876"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.42367696762085}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.7"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.456076145172119}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.9"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675187587738037}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.92117"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.92117"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675187587738037}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343238830566}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13359999999999994"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.8618388175964355}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343238830566}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.036584854125977}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0527558336884004"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84789"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.918221950531006}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90647"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.901963710784912}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.16"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84876"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.17"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89912"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.88039"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.88039"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736186906064397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89932"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}},{"name":"GM.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647790908813477}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647790908813477}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000102","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0079043361863298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7709600000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.985507965087891}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.762627124786377}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000104","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.607783317565918}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.551803112030029}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}},{"name":"GS.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000106","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651515960693}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651515960693}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030636310577393}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030636310577393}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.517807483673096}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704747676849365}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704747676849365}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.6","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000112","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.451866626739502}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"internal_bb69915a","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103416442871}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103416442871}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.436974048614502}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.436974048614502}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.918066501617432}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.918066501617432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000118","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.826663017272949}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.56931734085083}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"internal_d2763520","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000120","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.986824739722089"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.70075"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000121","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000123","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000124","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.257803916931152}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.257803916931152}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000125","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.203644752502441}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13359999999999994"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GJ.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"designation_date":{"value":"2023-06-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000131","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89912"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.32551383972168}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.32551383972168}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000135","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734275817871}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734275817871}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.842318534851074}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_XBB1_out","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.060752868652344}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.060752868652344}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.10"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13558"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.3"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49564"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.381250858306885}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000137","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980052947998}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.33"},"designation_date":{"value":"2023-04-18"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0545"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.49"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89405"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.542015552520752}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.20"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.48"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.9722600000000003"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000139","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.2"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"XBB.1.19","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000141","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000142","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000143","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000144","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000145","node_attrs":{"div":54,"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.2","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"internal_ORF8stop","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1269187927246094}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.21"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86729"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.27"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2602599999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.29"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.36"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3860321044921875}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.40"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.7"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.885027885437012}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.6"},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.8"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000147","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12"},"designation_date":{"value":"2023-02-09"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12.1"},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}},{"name":"XBB.1.13","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000149","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926177978515625}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926177978515625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.37.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43.1"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.43","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211505889893}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211505889893}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306163787842}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.45","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306163787842}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000156","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.1"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.2"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4"},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.1"},"designation_date":{"value":"2022-11-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9892516136169434}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.2"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34"},"designation_date":{"value":"2023-04-20"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000160","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296717643737793}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.30"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.751910209655762}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.39"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.072850227355957}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32.1"},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.578298091888428}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05231"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000163","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"FW.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.094683647155762}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1"},"designation_date":{"value":"2023-05-01"},"frameShifts":{"value":"ORF6:3-62"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000165","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}},{"name":"FW.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"designation_date":{"value":"2023-08-22"},"frameShifts":{"value":"ORF6:3-62"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.714374542236328}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547362804412842}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.98364782333374}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000169","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000170","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7388600000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296717643737793}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.080835342407227}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.2"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.35"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.46"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.2145609855651855}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000173","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05408"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000174","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.77537202835083}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"NODE_0000179","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"HE.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65784"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.2"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1099290580037755"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6066099999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65784"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000183","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JW.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000185","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.68441104888916}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000186","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"internal_b1afb4e5","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.43418"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.2"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"XBB.1.17","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000190","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.111379623413086}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.10","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"GA.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000191","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GA.10.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"designation_date":{"value":"2023-12-03"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","G13822A","A19307G","G22927T","T22928C","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["V119I","K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: V119I, K1947R; ORF9b: T95M; S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"GA.2.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80721"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","T6640C","C9857T","C10279T","A12235G","A22910G","G23222A","A25927T","C29002T"],"ORF1a":["M85-"],"ORF3a":["I179F"],"S":["N450D","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF3a: I179F; S: N450D, E554K","spike_mutations":"N450D, E554K"}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GA.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000194","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.96117"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000195","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90647"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000196","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5"},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.110"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.110"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.22"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.23"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.43"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.543598651885986}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.45"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.57"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.463161468505859}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.58"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.87"},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.87"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93509"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873941659927368}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873941659927368}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2755987644195557}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.10"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.101"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.101"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.104"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.104"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.082747936248779}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.105"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.105"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.109"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.109"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.108"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.108"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.12"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.64321231842041}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.11"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.960800886154175}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.18"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7349727153778076}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.2"},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.002401351928711}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.28"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8485686779022217}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.29"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41404999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.31"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.887559652328491}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.34"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.28225564956665}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.35"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.06293249130249}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.33"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.639432191848755}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.36"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.254280090332031}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.40"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95377"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.198355674743652}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.52"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8478691577911377}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.51"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.54"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.59"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.106780052185059}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.63"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7503247261047363}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.64"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.169807434082031}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.62"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.189828872680664}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.66"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.67"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.767808198928833}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.69"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266829013824463}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.75"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.79"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.656114101409912}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.80"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.80"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.27465295791626}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.82"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.82"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.91194"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.85"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.85"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.914321422576904}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.97"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.97"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.99"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.99"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.98"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.98"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000202","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.174045562744141}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14"},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762266635894775}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.809102535247803}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762266635894775}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1023732112409157"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29094"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41123000000000004"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.282759666442871}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.728201150894165}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85055685043335}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3"},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.728201150894165}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456169128418}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456169128418}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994797945022583}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"designation_date":{"value":"2024-01-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994797945022583}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.50"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.71"},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48403999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"GC.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.03073601411565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9061"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.989251613616943}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.297218322753906}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.297218322753906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.091250896453857}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7416800000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.73864"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.285966396331787}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.285966396331787}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.830754280090332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.99921178817749}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}},{"name":"HS.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.830754280090332}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020680904388428}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1186099999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5119218826293945}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020680904388428}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}},{"name":"FZ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}},{"name":"HZ.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.319439888000488}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}},{"name":"HC.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576805830001831}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0346353162114479"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9873000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.174569606781006}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576805830001831}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.26"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054046630859}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054046630859}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3490142822265625}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.842705249786377}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"GN.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3490142822265625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889133453369}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889133453369}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{}}},{"name":"KK.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2868306565498102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.20635"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"KK.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}}]},{"name":"NODE_0000244","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376293182373}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3046787170970133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1261900000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.11","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.10","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70"},"designation_date":{"value":"2023-05-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GK.5.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"GK.3.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.486576080322266}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"NODE_0000251","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136261463165283}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136261463165283}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}},{"name":"GK.1.11","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.6.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}},{"name":"GK.1.8","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000259","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":51,"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3541583181563797"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446400000000003"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.4131407737731934}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.106"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.106"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.19"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062247276306152}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.20"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6764075756073}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.25"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.187679290771484}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.27"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.515899181365967}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.32"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6741185188293457}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.37"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5378670692443848}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.5"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0984206199646}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.56"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.201076507568359}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.6"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.60"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.624792098999023}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.61"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265188694000244}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.65"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8305227756500244}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.72"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7908682823181152}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.74"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0169257119491577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9630099999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.76"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.102418422698975}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.8"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.449068546295166}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.78"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.81"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.81"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.6281256675720215}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.83"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.83"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.545153617858887}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.84"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.84"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2501959800720215}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.88"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.88"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.298462390899658}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.9"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.89"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.89"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.91"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.91"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.224147319793701}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.90"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.90"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.96"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.96"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.111899375915527}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.94"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.94"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.447929859161377}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"NODE_0000263","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.83085"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0655517578125}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689449310303}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.135179042816162}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689449310303}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000266","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9838451476656441"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.83156"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237003326416}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9350799999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237003326416}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000271","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8168466091156006}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.310755729675293}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8168466091156006}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.5945"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.5945"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]},{"name":"NODE_0000274","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.124101638793945}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}},{"name":"FT.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0924169334128189"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74638"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89299"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}},{"name":"FD.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"NODE_0000283","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038018703460693}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}},{"name":"FD.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038018703460693}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.754912853240967}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.25"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.5613484382629395}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.26"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.335569381713867}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.2106804847717285}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.2106804847717285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.3"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.79517126083374}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.79517126083374}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.950188045949472"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86018"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9788766097021935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.67693"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"NODE_0000288","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652244567871}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652244567871}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388861179351807}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}},{"name":"FY.6.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8926499999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}},{"name":"FY.8.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80106"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80106"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"internal_77ad61e0","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"designation_date":{"value":"2023-09-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"FY.5.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3639702796936035}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3639702796936035}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}},{"name":"FY.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000304","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"NODE_0000305","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.9962849617004395}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16"},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.9962849617004395}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.10","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.10"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.275190353393555}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.12"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.11"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.181058406829834}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.14"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7388600000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.17"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.19"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.18"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.089405059814453}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.16"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.20"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.22"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.21"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.24"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.23"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.26"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1827216148376465}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.25"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.27"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.28"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.4"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.5"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.7"},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.9"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.8"},"designation_date":{"value":"2023-05-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"NODE_0000307","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"KJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.64385"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.64385"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.29"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.30"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.31"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.640304088592529}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"HF.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121833324432373}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8289546966552734}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000315","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}},{"name":"JF.1.1.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.412325859069824}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.5","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"FU.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.14642"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.412325859069824}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000319","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}},{"name":"FU.1.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.968926429748535}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8164899999999998"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.5","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"GY.7","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.968926429748535}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"GY.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.09678840637207}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.23"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.1"},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1416096687316895}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.42","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000327","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191345691680908}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.941244125366211}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191345691680908}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.4"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.5"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.6"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13558"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.7"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000329","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036271572113037}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.331241607666016}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036271572113037}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927202224731445}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.12","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.064052581787109}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.11","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.14","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.2342681884765625}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.532744884490967}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.27","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.29","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7904599999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.217490196228027}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.6","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.7","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927202224731445}},"branch_attrs":{"mutations":{}}},{"name":"internal_d2a6176a","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.459027290344238}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9957660361777405"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0848"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}},{"name":"FL.26","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.459027290344238}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90046"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90046"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"NODE_0000336","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431282043457}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431282043457}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.516284465789795}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.887217044830322}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.919838905334473}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.35","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.887217044830322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.1391448974609375}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.1391448974609375}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747514724731445}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}},{"name":"FL.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747514724731445}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.97144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.17","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}}]},{"name":"NODE_0000342","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299052715301514}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299052715301514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.398621082305908}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.20.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5920999999999998"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}}]},{"name":"internal_10251222","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342810153961182}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1216394663867173"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.98073"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342810153961182}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.3","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000347","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8835"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"FL.23.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.96117"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.066182613372803}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}},{"name":"FL.3.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282451629638672}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282451629638672}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_566a3ed0","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_69bba568","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376365661621}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376365661621}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":35},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07635999999999983"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}},{"name":"FL.13.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.67327356338501}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"designation_date":{"value":"2023-05-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000356","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1684T","C11747T","C29236T"]}}},{"name":"FL.15.4","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}}}]},{"name":"NODE_0000358","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G6819A","G22927T"],"ORF1a":["T2007I","S2185N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I, S2185N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000359","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]},{"name":"NODE_0000361","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.463090896606445}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.671279430389404}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8957390785217285}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"FL.2.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.854552745819092}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.2.7","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_95ea4775","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4.10","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.888331413269043}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.11","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.458424091339111}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93509"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.9","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"FL.4.7","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.97144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"internal_12061207","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0186868047371063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3348299999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000368","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"NODE_0000369","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}},{"name":"FL.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.854552745819092}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9778643306477401"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89211"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000372","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000373","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"designation_date":{"value":"2023-08-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.06800999999999986"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000374","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000375","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.36653995513916}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000376","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000377","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3005141566416802"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0007299999999998658"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000378","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232714653015137}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000379","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254451751709}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254451751709}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]},{"name":"NODE_0000380","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"HN.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000381","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.61879825592041}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.13","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.12","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.14","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.7","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1186099999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.61879825592041}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17686"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}},{"name":"EG.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.20938"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17686"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616470336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000384","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1256300000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}},{"name":"EG.10.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1256300000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919017791748}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919017791748}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000386","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8845162391662598}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8845162391662598}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"designation_date":{"value":"2023-09-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07635999999999983"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000387","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.092266082763672}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.092266082763672}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EG.4.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000390","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541389226913452}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541389226913452}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.121776580810547}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.5","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.570929050445557}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}},{"name":"EG.1.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173191070557}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000393","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"NODE_0000394","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0384697914123535}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.64849853515625}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000395","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747878074645996}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747878074645996}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.772064208984375}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.292908191680908}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.374487400054932}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621211528778076}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.585853576660156}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000399","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"designation_date":{"value":"2023-11-29"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4312755323086508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.73257"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000400","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000401","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.504891872406006}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.471978664398193}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000403","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.9912302494049072}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.3","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8333635330200195}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3.4","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000404","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735766887664795}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735766887664795}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000405","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068490982055664}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068490982055664}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3341105633249508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0887599999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.10","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.025979999999999802"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8597540855407715}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.4","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.5","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.401525974273682}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.3","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3005451981781486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21974"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.8","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.7","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.9","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043656826019287}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.048559999999999943"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3552393372267753"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.38161000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.412596225738525}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000407","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000408","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":53,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000410","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1972306507819483"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13706999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.19","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.18","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.21","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.205901853206978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.1481699999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.310148541751831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.49366"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"designation_date":{"value":"2023-11-27"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.29","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.267586708068848}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.28","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.32","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.31","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.25141716003418}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.30","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.7","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2183176254438959"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.6088199999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000417","node_attrs":{"div":51,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3534097328298118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.48614000000000007"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000421","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.570084095001221}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HK.27.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.213572025299072}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.213572025299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000425","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.15","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.9","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.64849853515625}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"HK.8","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366167068481445}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3.10","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366167068481445}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.934603691101074}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.4","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.7","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.5","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.9","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.3123884201049805}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.16","node_attrs":{"div":1,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.16"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.231195449829102}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.15"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.830538272857666}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.19"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.504542827606201}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"partiallyAliased":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2791748046875}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87.1"},"designation_date":{"value":"2024-02-01"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":41},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6657453429914796"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8217399999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}},{"name":"BA.2.87","node_attrs":{"div":1,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2791748046875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.703927040100098}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3"},"designation_date":{"value":"2021-12-14"},"totalAminoacidSubstitutions":{"value":44},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.8266096115112305}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1"},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.807485044002533}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.9166173934936523}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.1350862979888916}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000435","node_attrs":{"div":63,"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8540998697280884}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8540998697280884}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000436","node_attrs":{"div":66,"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066323280334473}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066323280334473}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":83,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2"},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.5603076219558716}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E156-","F157-","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"B","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B"},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{}}},{"name":"A","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A"},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"A"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.945819139480591}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}}]}]}]}]}]}]},{"name":"NODE_0000438","node_attrs":{"div":1,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4824707508087158}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.1"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.958989143371582}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.11"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.020416736602783}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.18"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.061755418777466}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.20"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9340524673461914}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.24"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.01261797446067892"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0435516834259033}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.27","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.27"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9488906860351562}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.28","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.28"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.955256462097168}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.29"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.246367931365967}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.26","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.26"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5775980949401855}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.32","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.32"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7237727642059326}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.30","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.30"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.182343006134033}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.39","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.39"},"designation_date":{"value":"2022-05-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.341081619262695}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.41","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.41"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7299158573150635}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.43","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.43"},"designation_date":{"value":"2022-05-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11284999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.410249710083008}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.4","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.4"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7205681800842285}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.42","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.42"},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.5","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.5"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.587897777557373}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.46"},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.784327030181885}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.48","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.48"},"designation_date":{"value":"2022-06-01"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.789991855621338}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.50"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.21274471282959}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.55"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.215762615203857}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.59","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.59"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.600702285766602}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.54","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.54"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.1376729011535645}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.58"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.052984714508057}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.61","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.61"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.49704647064209}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.62"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.998417377471924}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.63","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.63"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172097206115723}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.64","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.64"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5229692459106445}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.60","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.60"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.65","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.65"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8462483882904053}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.70","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.70"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.472927093505859}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.77"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3221048136122174"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9213199999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.581743240356445}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.82","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.82"},"designation_date":{"value":"2022-08-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.82"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.2169976234436035}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.8","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.8"},"designation_date":{"value":"2022-03-28"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3260767459869385}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.83"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.22071783986880583"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.83"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.12534"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.85"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.85"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.299956321716309}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000439","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565171957015991}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565171957015991}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2.1"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000440","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1333484649658203}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1333484649658203}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23.1"},"designation_date":{"value":"2022-05-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8213231563568115}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.867221832275391}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.31","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8213231563568115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000442","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8927619457244873}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.35","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.35"},"designation_date":{"value":"2022-04-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.570833206176758}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.33","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.33"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086804389953613}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797025442123413}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797025442123413}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40.1"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7479588985443115}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000444","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9644880294799805}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56"},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9644880294799805}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56.1"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.697122097015381}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"BA.2.10_internal","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636719226837158}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636719226837158}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.2"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.685617685317993}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.3"},"designation_date":{"value":"2022-05-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.080300331115723}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.4"},"designation_date":{"value":"2022-08-09"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3166622371297313"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.73328"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.095381259918213}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.472888946533203}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1"},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.472888946533203}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1.1"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6181860283242497"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.09519000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000447","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.6233313083648682}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.14"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.639008045196533}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.22"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2793376445770264}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.36"},"designation_date":{"value":"2022-05-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.069880962371826}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.34","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.34"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.04110860824585}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.45","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.45"},"designation_date":{"value":"2022-05-23"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.638923168182373}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.49","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.49"},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7811052799224854}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.47","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.47"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.130137920379639}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.52","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.52"},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8808929920196533}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.51","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.51"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6952691078186035}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.53","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.53"},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.6","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.6"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6632723808288574}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.69"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9400291442871094}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.71","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.71"},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.660404682159424}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.7","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.7"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.356358766555786}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.72","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.72"},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6165003776550293}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.80"},"designation_date":{"value":"2022-07-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.31190394480802347"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.80"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10838000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6450419425964355}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.81"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.81"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.347171783447266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.490032196044922}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.490032196044922}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25.1"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.996252536773682}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.739166498184204}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.44"},"designation_date":{"value":"2022-05-21"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11284999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.218892574310303}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5540249347686768}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13.1","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13.1"},"designation_date":{"value":"2022-07-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.024052619934082}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}},{"name":"BA.2.13","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13"},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5540249347686768}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.19162917137146}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.19162917137146}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.2"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6204254627227783}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.4"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.5"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.238983154296875}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.1","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.1"},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.3"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.352891683578491}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.7"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.828467607498169}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.6"},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.504576683044434}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}}]}]},{"name":"BA.2.3_internal","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485034465789795}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.10","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.10"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.098453044891357}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485034465789795}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.1"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.11"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797952890396118}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.13"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.348180055618286}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.14"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9584250450134277}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.17"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.899256467819214}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.15"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8729326725006104}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.12"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.18"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.462869644165039}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.19"},"designation_date":{"value":"2022-07-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.702392578125}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.5"},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.302077293395996}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.4"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.8"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.9"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8521361351013184}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.7"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020241260528564}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"internal_305a","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43687237373984505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9456899999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601465225219727}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06758"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.848114013671875}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4733677107846063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"DD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9683399999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000455","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.171501159667969}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.22"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.42289430257523936"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.37526000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.6"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.009505271911621}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9327023029327393}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2"},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9327023029327393}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000457","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4975483601650658"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66821"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}},{"name":"BS.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1"},"designation_date":{"value":"2022-09-12"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.49181526572268314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66194"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"designation_date":{"value":"2022-09-30"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6029918987948071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6589000000000002"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_a315","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666072845459}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666072845459}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.10"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7593324873420084"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8190299999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000459","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7016283989012374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.91683"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"CM.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8143059671640498"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9440299999999998"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}},{"name":"CM.6","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_7ac4","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7255583352017505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.99403"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000463","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000464","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000465","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0761544902802131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"FV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.28625999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.12"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.11"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0179803928276123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35566999999999993"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.9"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"CM.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000468","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287181854248}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000469","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9785485534494837"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9729599999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.128720760345459}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.17"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.112698078155518}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.21"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9177675247192383}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.37"},"designation_date":{"value":"2022-05-03"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1007766723632812}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.57"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.16643762588501}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.68","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.68"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.936066150665283}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.66","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.66"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.675917148590088}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.74","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.74"},"designation_date":{"value":"2022-06-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.33134042675697756"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21698000000000003"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.888683795928955}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.73","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.73"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.040534496307373}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.78","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.78"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.664737701416016}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000471","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0960655212402344}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.67"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000472","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79.1"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000473","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6619465351104736}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76"},"designation_date":{"value":"2022-07-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6619465351104736}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000474","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.1"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.2640232066165751"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18492"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}},{"name":"BA.2.76.2","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.2"},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.444322347640991}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38"},"designation_date":{"value":"2022-05-06"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.444322347640991}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"partiallyAliased":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.7409892082214355}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3"},"designation_date":{"value":"2022-08-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.07383293656037815"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.08445999999999997"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.7409892082214355}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3.1"},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.370455061085298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.580890655517578}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000477","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9894256591796875}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.1"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086116313934326}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000478","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.909890174865723}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.2"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.319439888000488}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.4"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.4497761726379395}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7863521575927734}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7863521575927734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.2"},"designation_date":{"value":"2022-06-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.062348652344665065"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07350000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9584996700286865}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.057555675506592}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.057555675506592}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000481","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292704820632935}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.1"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.2"},"designation_date":{"value":"2022-06-18"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0345394611358643}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.4","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.6","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.6"},"designation_date":{"value":"2022-08-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}},{"name":"BG.5","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.5"},"designation_date":{"value":"2022-07-28"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.7","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.7"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.3","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.862102746963501}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.862102746963501}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.10"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.499692916870117}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.7"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.544760227203369}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.8"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04854"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81858"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.514627456665039}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13451"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000485","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7472099999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7472099999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.37898588180542}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.3"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5588825437629772"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.24593"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000487","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9449499999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9449499999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7451886007636047"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.12575999999999996"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000488","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.4"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5013910005227346"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.10514"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000489","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5"},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03573"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03573"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}}]}]}]}]},{"name":"NODE_0000490","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100636959075928}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100636959075928}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.4"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000491","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210721492767334}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.5"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.16854"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"BL.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.3"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"NODE_0000492","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590966701507568}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.043233394622803}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}},{"name":"BL.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590966701507568}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000493","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.178379535675049}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.178379535675049}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.19193"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.3464399999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6011952983295785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.56756"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.973597526550293}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.1.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.6"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5544855553668998"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.11979"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.6811747550964355}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.6811747550964355}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275516986846924}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275516986846924}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_147e","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41646999999999995"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263591289520264}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2"},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263591289520264}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41646999999999995"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.716527938842773}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.4","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.4"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.6"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"CA.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.7"},"designation_date":{"value":"2022-10-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.5"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2371799999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.580175399780273}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}},{"name":"CA.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000500","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096987247467041}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096987247467041}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.4"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14197"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.784380912780762}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.6"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.5"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227935791015625}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227935791015625}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14197"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488797664642334}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5060716304521155"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.11385"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488797664642334}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.653690335850791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.9134323596954346}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}}]},{"name":"NODE_0000503","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420084476470947}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420084476470947}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.11","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.977697372436523}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.8","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9193315170816834"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5340599999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.7","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"NODE_0000504","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.2021600000000001"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.2021600000000001"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000505","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842318534851074}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7815531080803261"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.31233"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}},{"name":"BN.1.5.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7470314258752732"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1331"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]}]},{"name":"NODE_0000507","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000508","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735761642456055}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.108586311340332}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}},{"name":"BN.1.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.1361188888549805}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"designation_date":{"value":"2022-11-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.22015380859375}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000510","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.501852035522461}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.501852035522461}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.775949239730835}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7326886306518271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.21326"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.376982688903809}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"NODE_0000511","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000512","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000513","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}},{"name":"FR.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}}]}]}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563655376434326}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563655376434326}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4979681968688965}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.060053825378418}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0513083167390975"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.16291"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}},{"name":"DS.3","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.12","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.114459037780762}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"designation_date":{"value":"2023-03-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.856032848358154}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.576071739196777}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.082351207733154}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.3","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"designation_date":{"value":"2023-08-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"designation_date":{"value":"2023-02-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.791740894317627}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.041548728942871}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000520","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307618141174316}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307618141174316}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.3"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301943778991699}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.6","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.6"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15852"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"BM.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.5"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15852"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.031525135040283}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000521","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.052262306213379}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.052262306213379}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5272935807019111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.26994"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.548510551452637}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78817"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.174620628356934}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}},{"name":"BM.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81858"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.425735950469971}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1"},"designation_date":{"value":"2022-08-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.425735950469971}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78306245803833}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78306245803833}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000525","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458258628845215}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}},{"name":"BM.1.1.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}}]},{"name":"NODE_0000526","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.028015613555908}},"branch_attrs":{"mutations":{"nuc":["C3130T","C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.028015613555908}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"designation_date":{"value":"2022-12-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000527","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","C3130T","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.46466000000000013"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000528","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.46466000000000013"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000529","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000530","node_attrs":{"div":39,"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]},{"name":"internal_f6c6","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.266562461853027}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.43724"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.266562461853027}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273096084594727}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273096084594727}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000533","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"designation_date":{"value":"2022-12-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9457248359372292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.87567"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.26216459274292}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000534","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}},{"name":"CJ.1.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539737701416016}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539737701416016}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628327369689941}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628327369689941}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506646633148193}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506646633148193}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000538","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852518558502197}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"CH.3.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0219999999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7685109779549473"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36891999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000541","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000542","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.21","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"designation_date":{"value":"2023-03-29"},"frameShifts":{"value":"ORF7a:59-122"},"totalAminoacidSubstitutions":{"value":69},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.9441222497200389"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.08511000000000003"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}},{"name":"CH.1.1.18","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}}]},{"name":"NODE_0000543","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000544","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9334899999999999"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}},{"name":"GQ.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9334899999999999"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000545","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.328583240509033}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8057045936584473}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0050458908081055}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"internal_ddb1","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000547","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363282680511475}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363282680511475}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000554","node_attrs":{"div":40,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000555","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000558","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000559","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000560","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000561","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000562","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000563","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462226867676}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"designation_date":{"value":"2023-01-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000564","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000565","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000566","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000567","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"designation_date":{"value":"2023-09-24"},"frameShifts":{"value":"ORF7a:62-122"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:62-122"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000569","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"designation_date":{"value":"2023-03-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000571","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000573","node_attrs":{"div":37,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.3224663734436035}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"designation_date":{"value":"2023-04-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.3224663734436035}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9815994835819151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.16085999999999998"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000576","node_attrs":{"div":43,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000577","node_attrs":{"div":50,"partiallyAliased":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.661655902862549}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86"},"designation_date":{"value":"2023-08-17"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.661655902862549}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.5"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"NODE_0000578","node_attrs":{"div":52,"partiallyAliased":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}},{"name":"LV.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.2"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}}]},{"name":"NODE_0000579","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7"},"designation_date":{"value":"2024-06-13"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000580","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.6738025507980547"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000581","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.1"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000582","node_attrs":{"div":56,"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2"},"designation_date":{"value":"2024-03-05"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15919"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000583","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"designation_date":{"value":"2024-03-20"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000584","node_attrs":{"div":52,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.782770156860352}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.4"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.518976211547852}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000585","node_attrs":{"div":53,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.8259432315826416}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1"},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.8259432315826416}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.12"},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.14","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.14"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.16","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.16"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.17","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.17"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.15","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.15"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.18","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.18"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.01167631149292}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.19","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.19"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.808485507965088}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.6"},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.8","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.8"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.7","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.7"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.9"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"NODE_0000586","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11"},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000587","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13"},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000588","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5"},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6465599999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000589","node_attrs":{"div":55,"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.34682559967041}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.34682559967041}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000590","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"ORF1a":["P892S"]},"labels":{"aa":"N: H300Y; ORF1a: P892S"}},"children":[{"name":"JN.3.2","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]}]},{"name":"internal_59b29264","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.4","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.5","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000592","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000593","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.369624137878418}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.10"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.50243616104126}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000594","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7884089946746826}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1"},"designation_date":{"value":"2023-09-29"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7884089946746826}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.408935546875}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26806999999999986"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217947959899902}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9045872688293457}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062774658203125}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.875373840332031}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.674196720123291}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.493675231933594}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491053104400635}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407819747924805}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.03013801574707}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.296980381011963}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.23248815536499}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.804255247116089}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.117530822753906}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.341228008270264}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.62","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"designation_date":{"value":"2024-06-08"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.61","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.496607246855186"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93036"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407478332519531}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.66","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086578369140625}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.971951007843018}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086578369140625}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240832328796387}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"designation_date":{"value":"2024-02-20"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.21099"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240832328796387}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.23.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.21099"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012979507446289}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3227739334106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012979507446289}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.162879467010498}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.261645793914795}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"JN.1.32","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.162879467010498}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844123840332031}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844123840332031}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.38.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.390693187713623}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}},{"name":"JN.1.43","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.390693187713623}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741860389709473}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.848097324371338}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.44","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741860389709473}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.473700046539307}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.473700046539307}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.532734695870142"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.05681999999999991"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906609058380127}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5395016697354735"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7602899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906609058380127}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2344651222229}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2344651222229}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.492700099945068}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803304672241211}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803304672241211}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":8.507},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"NODE_0000606","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1652140617370605}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1652140617370605}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7444634437561035}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.048468589782715}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.048468589782715}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250581741333008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250581741333008}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395020484924316}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395020484924316}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341370105743408}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341370105743408}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"designation_date":{"value":"2024-07-10"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4552719593048096}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.33223295211792}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.33223295211792}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.063129425048828}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005730152130127}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.993558406829834}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005730152130127}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4039130210876465}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4039130210876465}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.081502914428711}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.081502914428711}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.51407527923584}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.51407527923584}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.771152973175049}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.627852916717529}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}},{"name":"JN.1.55.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}}]}]},{"name":"NODE_0000618","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.6971025466918945}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.6971025466918945}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000619","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.189657688140869}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.189657688140869}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.898664951324463}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.853456020355225}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"JN.1.39","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.898664951324463}},"branch_attrs":{"mutations":{}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1753339767456055}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.563376426696777}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655728340148926}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"designation_date":{"value":"2024-04-02"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.302780628204346}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"JN.1.42","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"designation_date":{"value":"2024-03-25"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655728340148926}},"branch_attrs":{"mutations":{}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"designation_date":{"value":"2024-05-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"designation_date":{"value":"2024-08-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"designation_date":{"value":"2024-05-18"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"ME.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.27215999999999985"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.891266345977783}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.891266345977783}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834461688995361}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834461688995361}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000628","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2595099999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343695163726807}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343695163726807}},"branch_attrs":{"mutations":{}}},{"name":"internal_dafb7842","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5484747886657715}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5484747886657715}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693490982055664}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.124732494354248}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688722133636475}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566845893859863}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.104548454284668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"NODE_0000637","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000639","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.500879287719727}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.500879287719727}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000640","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438821315765381}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.6234025955200195}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000641","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617192268371582}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617192268371582}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.780251502990723}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.780251502990723}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424532413482666}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424532413482666}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753118515014648}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.045562267303467}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"designation_date":{"value":"2024-08-20"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.396651744842529}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000647","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.625002384185791}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.625002384185791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000648","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000649","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3745641202332524"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9318500000000001"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000650","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"designation_date":{"value":"2024-04-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000651","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772459506988525}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.320776462554932}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772459506988525}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.515129089355469}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000655","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.30217999999999995"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000657","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.307804584503174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.224503517150879}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.58","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.307804584503174}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.408945083618164}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872630596160889}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872630596160889}},"branch_attrs":{"mutations":{}}},{"name":"LR.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}},{"name":"LR.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4686198234558105}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.532440185546875}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.532440185546875}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.34312105178833}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.34312105178833}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.9152421951293945}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.9152421951293945}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.229276180267334}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005531311035156}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.02389"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.469202041625977}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.105811595916748}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.09798002243042}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309722900390625}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309722900390625}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.690683841705322}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.175650596618652}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08313"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.566635608673096}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000671","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000672","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347302436828613}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347302436828613}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04395"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.99325704574585}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95433"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.99325704574585}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.711982011795044}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.776760578155518}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.711982011795044}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.743708610534668}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924505710601807}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924505710601807}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000677","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.816462993621826}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0927324295043945}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.036890506744385}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"designation_date":{"value":"2024-02-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685323238372803}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685323238372803}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782630443572998}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782630443572998}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.02389"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000681","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769372940063477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769372940063477}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145790100097656}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000682","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}},{"name":"LE.1.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5281498432159424}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5281498432159424}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000684","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642734527587891}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642734527587891}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3354692459106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972527980804443}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972527980804443}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69521951675415}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}},{"name":"KZ.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69521951675415}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000689","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227226734161377}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.8855462074279785}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.850363254547119}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000690","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000691","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":11.111},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2408299999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000692","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.3","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}},{"name":"KR.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}}]}]}]}]},{"name":"NODE_0000693","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056233882904053}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056233882904053}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.607518196105957}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145547866821289}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145547866821289}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000695","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9964990615844727}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"designation_date":{"value":"2024-04-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9964990615844727}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.6","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69572114944458}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.8","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.729191780090332}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2408299999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000696","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558164119720459}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"designation_date":{"value":"2024-08-24"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}},{"name":"LB.1.4.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558164119720459}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000697","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624444961547852}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.662596225738525}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624444961547852}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}},{"name":"LB.1.7.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}}]},{"name":"NODE_0000699","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111886501312256}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111886501312256}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438388347625732}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.472174167633057}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.925361394882202}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.925361394882202}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347464084625244}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415004730224609}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415004730224609}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.04741999999999978"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000704","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.689547538757324}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005441188812256}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"NODE_0000706","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.083190441131592}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.083190441131592}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.09660530090332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.7","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":50.174},"immune_escape":{"value":"1.817229820305529"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21767999999999987"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"LF.6","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.9","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.557812213897705}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.290716171264648}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.290716171264648}},"branch_attrs":{"mutations":{}}},{"name":"LF.4.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}}]},{"name":"NODE_0000708","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693272590637207}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C28660T"],"S":["T33A"]},"labels":{"aa":"S: T33A","spike_mutations":"T33A"}}},{"name":"LF.9.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5064377784729}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"designation_date":{"value":"2024-05-28"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"designation_date":{"value":"2024-06-29"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"designation_date":{"value":"2024-06-04"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000713","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000714","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}},{"name":"LF.8.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.106093406677246}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.106093406677246}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9550347328186035}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9550347328186035}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688606262207031}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688606262207031}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.221215724945068}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.829525470733643}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.829525470733643}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.795657634735107}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":11.111},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3926199999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.450676441192627}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.450676441192627}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.520935535430908}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.721512317657471}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"NODE_0000724","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.106141090393066}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"NODE_0000726","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.159374713897705}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.159374713897705}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7445478439331055}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000727","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"NODE_0000728","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G"],"ORF1a":["K1226E"]},"labels":{"aa":"ORF1a: K1226E"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}},{"name":"LZ.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"designation_date":{"value":"2024-08-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]},{"name":"internal_24bd909c","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.753526210784912}},"branch_attrs":{"mutations":{"nuc":["C22928T"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.753526210784912}},"branch_attrs":{"mutations":{"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"internal_41eb7227","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"]},"labels":{"aa":"N: A152T; ORF1a: I740V"}},"children":[{"name":"LZ.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]}]}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858033657073975}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858033657073975}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.04741999999999978"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.008905410766602}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.3277153968811035}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.3277153968811035}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000734","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206735610961914}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7741516492587035"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.27333999999999997"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"KP.4.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{}}},{"name":"internal_7da46150","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000738","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679376125335693}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"designation_date":{"value":"2024-02-22"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679376125335693}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.903770923614502}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064724922180176}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064724922180176}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000743","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"internal_bfd296bd","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785137176514}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.9018449783325195}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000745","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013365268707275}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013365268707275}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.616637229919434}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.12","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.10","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.455721378326416}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.14","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.764108657836914}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.096656322479248}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.764108657836914}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"internal_1e4c8e87","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.2861931324005127}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7908990401504723"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000750","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000751","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.9161720275878906}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21942999999999988"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.532754421234131}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.17","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.18","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.5323338508605957}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.7","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206735610961914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.2.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.6","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.883235454559326}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}}]}]},{"name":"NODE_0000752","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987194061279297}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987194061279297}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519747734069824}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519747734069824}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5554650921238282"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15242"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"NODE_0000755","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125619888305664}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"designation_date":{"value":"2024-06-09"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.35004997253418}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":70,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.607268810272217}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.607268810272217}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000761","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000763","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7206397516519647"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.11924"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000765","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.12","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.857026100158691}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.10","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.15","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.14","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.4","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.8321967124938965}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.3","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.6","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.7","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5369762101413171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000767","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787517547607}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787517547607}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.619511127471924}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000771","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.494636058807373}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.8"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.494636058807373}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325202703475952}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325202703475952}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.2"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000773","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.914329767227173}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.5","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.5"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.328583240509033}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.3","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.622591733932495}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.7","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.7"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000774","node_attrs":{"div":10,"partiallyAliased":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.785727024078369}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.785727024078369}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.1"},"designation_date":{"value":"2022-09-05"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.2","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.4"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.3"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.71883"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"NODE_0000775","node_attrs":{"div":11,"partiallyAliased":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"DC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66094"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000776","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947989463806152}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1.1","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.1"},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1"},"designation_date":{"value":"2022-05-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947989463806152}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.5"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.291128635406494}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.100764274597168}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.6"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.0240254402160645}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.9"},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.8"},"designation_date":{"value":"2022-07-29"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8587090969085693}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000777","node_attrs":{"div":8,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.2"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000778","node_attrs":{"div":9,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.11"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000779","node_attrs":{"div":11,"partiallyAliased":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5308081831240151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.67074"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7561969850799493"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"CS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5702799999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000780","node_attrs":{"div":12,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1984522342681885}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1984522342681885}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.9"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39901000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2395055294036865}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"NODE_0000781","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.000426292419434}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"ORF1a":["M2096L"]},"labels":{"aa":"ORF1a: M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.8"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3900210857391357}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000782","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.946847438812256}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.946847438812256}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.5.2","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.2"},"designation_date":{"value":"2022-08-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.243048667907715}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"NODE_0000783","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891695261001587}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.1"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5131304264068604}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.3"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.187767505645752}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0000784","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0763676166534424}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0763676166534424}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000785","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130263805389404}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.3"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.1"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.4","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.4"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5883099999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000786","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2"},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000787","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6570799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000788","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.391442775726318}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"designation_date":{"value":"2022-11-20"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000789","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2668371200561523}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"]}},"children":[{"name":"BA.5.1.11","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.11"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2668371200561523}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.16","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.16"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9540939331054688}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.12","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.12"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4273571968078613}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.14"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.965997695922852}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.17","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.17"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.774637222290039}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.2"},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.26383900642395}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.24"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3640353679656982}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.28"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.258055686950684}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.30","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.30"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9021799564361572}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.3","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1503868103027344}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.34","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.34"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.5"},"designation_date":{"value":"2022-07-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1470391750335693}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.4","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.4"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.6","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.6"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.541717290878296}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.8","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.8"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6331067085266113}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"BA.5.1.7","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.886288642883301}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"NODE_0000790","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3361656665802}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3361656665802}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10.1"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0975565910339355}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0975565910339355}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15.1"},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000792","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213085651397705}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213085651397705}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000793","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"NODE_0000794","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33.1"},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_35cd","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.303285837173462}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.31"},"designation_date":{"value":"2022-11-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.38"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198990821838379}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198990821838379}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_bae4","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8467977046966553}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8467977046966553}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1158230304718018}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.1"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}},{"name":"DE.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.2"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}}]}]},{"name":"NODE_0000799","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.430185079574585}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.18"},"designation_date":{"value":"2022-08-28"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7965612411499023}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000800","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069729328155518}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069729328155518}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.1"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.2"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8074238300323486}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8074238300323486}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.113799095153809}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.113799095153809}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000803","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.255287170410156}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"designation_date":{"value":"2022-12-10"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"designation_date":{"value":"2022-12-23"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000804","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}},{"name":"DJ.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5218353271484375}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.27"},"designation_date":{"value":"2022-09-30"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29"},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000807","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"CL.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.56931734085083}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0000809","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.73331618309021}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.083285093307495}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.19"},"designation_date":{"value":"2022-09-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047452926635742}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.32"},"designation_date":{"value":"2023-01-15"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.9"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.180713176727295}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000810","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.134702682495117}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.20"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.535201072692871}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.37","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.37"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}},{"name":"BA.5.1.36","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.36"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}}]}]}]},{"name":"NODE_0000811","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.151430368423462}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.11"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.79317307472229}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000813","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000814","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}},{"name":"DF.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1"},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7135770320892334}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2"},"designation_date":{"value":"2022-05-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7135770320892334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000816","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.681718111038208}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.681718111038208}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.12"},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5279"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.980180025100708}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.17","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.17"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.486154556274414}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.19","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.19"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.18"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092384338378906}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.30"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.33"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6034899999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.4"},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5524494647979736}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.6"},"designation_date":{"value":"2022-07-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.914687395095825}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.8"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4910664558410645}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000817","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.093046188354492}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BF.14","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.14"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.080418825149536}},"branch_attrs":{"mutations":{"nuc":["C16726T"],"ORF1b":["H1087Y"]},"labels":{"aa":"ORF1b: H1087Y"}}},{"name":"BF.35","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.35"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I"}}}]},{"name":"NODE_0000818","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278829097747803}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278829097747803}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006065368652344}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5959379308450252"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.33263"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.380862712860107}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006065368652344}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141825199127197}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141825199127197}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000821","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765230655670166}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11"},"designation_date":{"value":"2022-07-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765230655670166}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.462978363037109}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000822","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.166635990142822}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.292905807495117}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0000823","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7687714099884033}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.789764165878296}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.28"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2670040130615234}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.36","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.36"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8735761642456055}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.9"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4620237350463867}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000824","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318788051605225}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318788051605225}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000825","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1384167671203613}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"designation_date":{"value":"2022-12-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.563032084337257"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3218"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.989957332611084}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1384167671203613}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000826","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1209096908569336}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.15"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.382328033447266}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.20"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.54063081741333}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000827","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.864675521850586}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.21"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1568257808685303}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.27"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3812053203582764}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000828","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.4587268829345703}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.13"},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.16"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.369956970214844}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.22"},"designation_date":{"value":"2022-08-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.25"},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.29"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.740654468536377}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.34"},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685994625091553}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.23"},"designation_date":{"value":"2022-09-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74171257019043}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.324922561645508}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.324922561645508}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48889999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278613567352295}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000831","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6619062423706055}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.24"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000832","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160460948944092}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160460948944092}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000833","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7555084228515625}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.592723846435547}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000834","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2662811279296875}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000835","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.605587959289551}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8483927249908447}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000836","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"designation_date":{"value":"2023-02-08"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000837","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.604166269302368}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.42"},"designation_date":{"value":"2023-04-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.397212505340576}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.26"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.32"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.259809494018555}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.37"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.417162895202637}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.40"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.287785291671753}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238624095916748}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238624095916748}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0000840","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7"},"designation_date":{"value":"2022-07-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"designation_date":{"value":"2022-10-05"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.541252613067627}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.11","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.68569278717041}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5383851528167725}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.18","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.512576103210449}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.17","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6393200000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7448058128356934}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.21","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.22","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.24","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.23","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.26","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.8","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2593913078308105}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"BF.7.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7265231609344482}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"NODE_0000841","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}},{"name":"BF.7.16","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000842","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}},{"name":"BF.7.19","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000843","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000844","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6759999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000845","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"designation_date":{"value":"2023-03-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.398621082305908}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000846","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762614250183105}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3122613430023193}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0000847","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000848","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.4","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"designation_date":{"value":"2023-01-25"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0000849","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.6","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000850","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6321210861206055}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.23"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8151862621307373}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.40","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.40"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.4"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.182602405548096}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.5","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.5"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.9"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.992319345474243}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000851","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2575464248657227}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.10"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.743116855621338}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.628093719482422}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000852","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8561782836914062}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8561782836914062}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26.1"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.20828914642334}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]},{"name":"NODE_0000853","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190244674682617}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.22"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.498509168624878}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.29","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.29"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.531074047088623}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.28","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.28"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.239920139312744}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.45","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.45"},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5131699999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998836994171143}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.52"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.161771774291992}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.55"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.999176263809204}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.59"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.273857116699219}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0000854","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9824576377868652}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9824576377868652}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39901000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.402865409851074}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0000855","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680343151092529}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680343151092529}},"branch_attrs":{"mutations":{}}},{"name":"DZ.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.2"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"DZ.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.57471227645874}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}}]}]},{"name":"NODE_0000856","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190244674682617}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.12"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3988966941833496}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.13"},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.693641424179077}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.14"},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.19"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7941062450408936}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.30"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.567555904388428}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.35","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.35"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.34","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.34"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.511683702468872}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.39","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.39"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.37"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460197448730469}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.42","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.42"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.43"},"designation_date":{"value":"2022-11-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5413273873731987"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5642800000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.44"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.282501697540283}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.46"},"designation_date":{"value":"2022-12-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.53"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.239439964294434}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.54"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.244083404541016}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.58","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.58"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236837387084961}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.57"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7188966274261475}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.62"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.200337886810303}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.63"},"designation_date":{"value":"2023-02-14"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.61","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.61"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.7162909507751465}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.8","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.8"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9471049308776855}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.359752178192139}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.11"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.216500282287598}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.32"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36507511138916}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.812325954437256}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.812325954437256}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.800739765167236}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_1651","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.183877944946289}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.183877944946289}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7208595659836455"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4564899999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.672420024871826}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3631205558776855}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.30660604695253"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.56458"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3631205558776855}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6759999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.4745917320251465}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000861","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.41"},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.726137638092041}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.56"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.041235446929932}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329526901245117}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329526901245117}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47.1"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000863","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4698426723480225}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4698426723480225}},"branch_attrs":{"mutations":{}}},{"name":"CN.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.2"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}},{"name":"CN.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.1"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.227382183074951}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000864","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.852180004119873}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.2"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.280703544616699}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"internal_6217","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.214096546173096}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.185972690582275}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.185972690582275}},"branch_attrs":{"mutations":{}}},{"name":"CD.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3253063676642168"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5594199999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}},{"name":"CD.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.559537887573242}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}}]},{"name":"NODE_0000867","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064776420593262}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.50"},"designation_date":{"value":"2023-01-21"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74055290222168}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.51","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.51"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.903770923614502}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.60"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585160255432129}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000868","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.2"},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.1"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.679447650909424}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0000869","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.1"},"designation_date":{"value":"2022-09-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.205173015594482}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.3"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}},{"name":"BU.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415644645690918}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25"},"designation_date":{"value":"2022-09-25"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415644645690918}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.356500625610352}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.3"},"designation_date":{"value":"2023-02-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.2"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.673305034637451}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"internal_93c4","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.993558883666992}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"internal_f379","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665871620178223}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665871620178223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000874","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3630194664001465}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.244806289672852}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40216999999999997"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000875","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131978988647461}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48"},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131978988647461}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.705625534057617}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000876","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}},{"name":"DY.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000877","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.89189076423645}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2117154598236084}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2117154598236084}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.3"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.38661"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.831022262573242}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.2"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5295255377787571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6942999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.206465244293213}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.6","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.6"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.885945796966553}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.4","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.4"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.632347583770752}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.5"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.982746124267578}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.7"},"designation_date":{"value":"2023-03-02"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"internal_7ebe","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}},{"name":"CP.8","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000880","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4362287521362305}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1"},"designation_date":{"value":"2022-10-13"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4362287521362305}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6003199999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}},{"name":"CP.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"designation_date":{"value":"2022-10-13"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.384659290313721}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.319679260253906}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}}]}]},{"name":"NODE_0000881","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071225166320801}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24"},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071225166320801}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.3"},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2413458824157715}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.667097091674805}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.667097091674805}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.376063346862793}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.376063346862793}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000884","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0000885","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.083762168884277}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.083762168884277}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0000886","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.002089500427246}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.71883"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.712406158447266}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0000887","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.607504844665527}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0000888","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.022320747375488}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"designation_date":{"value":"2022-12-29"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.022320747375488}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.657641887664795}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000889","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.170691967010498}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"ORF1a":["Q556K"]},"labels":{"aa":"ORF1a: Q556K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3"},"designation_date":{"value":"2022-05-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.170691967010498}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.3"},"designation_date":{"value":"2022-06-24"},"frameShifts":{"value":"ORF7a:72-122"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782665967941284}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.5"},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.307540416717529}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000890","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8095927238464355}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.4","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.4"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2507734298706055}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}},{"name":"BA.5.3.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.2"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9211783409118652}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}}]},{"name":"NODE_0000891","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{}}},{"name":"BE.2","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.800240993499756}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T"],"ORF1a":["T882I"]},"labels":{"aa":"ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.3"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2200911045074463}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.5"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000892","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.511610984802246}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.10"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.9"},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6685283184051514}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000893","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.290349960327148}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","T28693C"],"ORF1a":["M85-"]},"labels":{"aa":"ORF1a: M85-"}},"children":[{"name":"BE.7","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.7"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.395103931427002}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}},{"name":"BE.6","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.6"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.737630844116211}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}}]},{"name":"NODE_0000894","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.721144437789917}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.11","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.11"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.008347511291504}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"BE.12","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.12"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"NODE_0000895","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2481184005737305}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.13"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5088823627149919"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5231200000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.8"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":94},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":1},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0000896","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245568752288818}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T"],"ORF1a":["T3308N"]},"labels":{"aa":"ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245568752288818}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000897","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2813496589660645}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000898","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000899","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40216999999999997"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9200546741485596}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000900","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000901","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0249316692352295}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"ORF1b":["M1156I"]},"labels":{"aa":"ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0249316692352295}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.957712173461914}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000902","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295792102813721}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295792102813721}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000903","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8224959014481948"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49383999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000904","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0000905","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367693901062012}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"internal_874c","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.770998001098633}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.770998001098633}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000907","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190595626831055}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190595626831055}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000908","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.037123680114746}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"designation_date":{"value":"2022-08-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.037123680114746}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5680790723509552"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45205000000000006"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.677981376647949}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000909","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.380139112472534}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.380139112472534}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3855838775634766}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4368526935577393}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7257362514460642"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6127800000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6570799999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8308113969466171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5446"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.457104206085205}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.424003601074219}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4287261962890625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9463791847229}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.914119720458984}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"designation_date":{"value":"2023-03-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.936223268508911}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4588372707366943}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.657702922821045}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000910","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761812686920166}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761812686920166}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"designation_date":{"value":"2023-01-26"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000911","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7374396324157715}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000912","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000913","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.866491794586182}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.866491794586182}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000914","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009603500366211}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.068519592285156}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176229476928711}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176229476928711}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000917","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710925579071045}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710925579071045}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"BQ.1.26.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}}]}]},{"name":"NODE_0000919","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4316978454589844}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0000921","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6853534127590314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6353800000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.400434494018555}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688451290130615}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688451290130615}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875689029693604}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"NODE_0000925","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9874397743924017"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66664"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000926","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"designation_date":{"value":"2023-04-28"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60833"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"designation_date":{"value":"2023-08-31"},"frameShifts":{"value":"ORF7a:83-122"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":31},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0821590912755812"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6059300000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]},{"name":"internal_dbfb","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6925976779449897"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5174000000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7586450576782227}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.16","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.18","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.5464019775390625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4521586894989014}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.057005405426025}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.637410640716553}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000931","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3929214477539062}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"designation_date":{"value":"2022-09-09"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3929214477539062}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8915650844573975}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.535731315612793}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"designation_date":{"value":"2022-11-03"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.149692535400391}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.225134372711182}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8728938682420008"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5921799999999998"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.841220855712891}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7449699999999998"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.07365083694458}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60833"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.833066940307617}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.314393520355225}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.201074600219727}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9046709537506104}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.704440116882324}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.068450927734375}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9954097270965576}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.249934673309326}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.386298179626465}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.861405372619629}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.360784530639648}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530673503875732}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.3784332275390625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9752700328826904}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.371273994445801}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9168782234191895}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276081085205078}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.05605936050415}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.841140031814575}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.636171340942383}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.239450931549072}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.051732686328446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.731185436248779}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000932","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955434799194336}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955434799194336}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"designation_date":{"value":"2022-12-07"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.65602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.960555553436279}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7361","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2028326988220215}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2028326988220215}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.70602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.662565231323242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000934","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0995001792907715}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"designation_date":{"value":"2022-10-19"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0995001792907715}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"designation_date":{"value":"2023-01-12"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.108586311340332}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000935","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9425103664398193}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.781043529510498}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"designation_date":{"value":"2022-12-02"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.53029203414917}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000936","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500977039337158}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674434661865}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674434661865}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ET.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.596988677978516}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ES.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000939","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8486416339874268}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8486416339874268}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"designation_date":{"value":"2022-11-30"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74371"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.994874000549316}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_bf35","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6950554847717285}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6950554847717285}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000941","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9105813557217661"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66913"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452545166015625}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452545166015625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9185686111450195}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000943","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9088191986083984}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9088191986083984}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.810015678405762}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{}}},{"name":"CZ.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.435018539428711}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"CZ.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6774299999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}}]},{"name":"NODE_0000945","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000946","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952062606811523}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952062606811523}},"branch_attrs":{"mutations":{}}},{"name":"ER.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"designation_date":{"value":"2023-03-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}}]}]},{"name":"NODE_0000947","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"DR.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-01-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.548947334289551}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}}]},{"name":"NODE_0000948","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694454669952393}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694454669952393}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000949","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"EN.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}}]}]},{"name":"NODE_0000950","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.648621082305908}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.49","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.766948223114014}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.48","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.3889336585998535}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{}}},{"name":"EA.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.880706782961692"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.34834999999999994"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.922172546386719}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}},{"name":"EA.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478137016296387}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504777431488037}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504777431488037}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918827056884766}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.8300909996032715}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.188085079193115}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.897580623626709}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000954","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1676859855651855}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000955","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.43596076965332}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.43596076965332}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002801895141602}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002801895141602}},"branch_attrs":{"mutations":{}}},{"name":"DT.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.224767684936523}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}},{"name":"DT.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.392630577087402}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.660925388336182}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.117684841156006}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302687644958496}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000959","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{}}},{"name":"EE.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131553649902344}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.184222221374512}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.522237300872803}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.840277671813965}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}}]},{"name":"NODE_0000961","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.25513219833374}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000962","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0000963","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"designation_date":{"value":"2023-04-17"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000964","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"designation_date":{"value":"2023-03-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24659999999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24659999999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]},{"name":"NODE_0000965","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"designation_date":{"value":"2023-01-24"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.65602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"NODE_0000966","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1417622566223145}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1417622566223145}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.072010040283203}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1802849769592285}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1802849769592285}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000968","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138624668121338}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"EF.1.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"internal_e491","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000970","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656734943389893}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656734943389893}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000971","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024628162384033}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024628162384033}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.699550151824951}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000972","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-7.3331193923950195}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"DN.3","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000973","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000974","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8771384492554943"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5626099999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8990816968865659"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.05606"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8744814686582322"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6722600000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLGRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGGGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGATGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTTTAATTGTTACTTTCCTTTACGATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/BA.2/tree.json.bak b/data/nextstrain/sars-cov-2/BA.2/tree.json.bak new file mode 100644 index 00000000..dd722505 --- /dev/null +++ b/data/nextstrain/sars-cov-2/BA.2/tree.json.bak @@ -0,0 +1 @@ +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/BA.2/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["E31-","R32-","S33-"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF9b":["E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S"]},"labels":{"aa":"N: E31-, R32-, S33-; ORF1a: S3675-, G3676-, F3677-; ORF9b: E27-, N28-, A29-; S: L24-, P25-, P26-, A27S","clade":"Omicron","spike_mutations":"L24-, P25-, P26-, A27S"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2"},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.14300012588501}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAB","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAB"},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.431697368621826}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAA","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAA"},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAE","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAE"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAD","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAD"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.878465175628662}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAC","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAC"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAF"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAH","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAH"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.748097896575928}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAG","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAG"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.583486080169678}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAL","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAL"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAJ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAJ"},"designation_date":{"value":"2022-07-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.648314476013184}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAK","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAK"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3037714005953052"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAQ","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAQ"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAN","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAN"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081246376037598}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAM","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAM"},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAP","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAP"},"designation_date":{"value":"2022-07-30"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.999915599822998}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAR","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAR"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.451335430145264}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAT","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAT"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.875851154327393}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAU","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAU"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.17326545715332}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAS","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAS"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.452675819396973}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":82,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAW"},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.274687314409391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E156-","F157-","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAV","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAV"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.7257537841796875}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAZ","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAZ"},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.731168270111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBA"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.29808642936638835"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBD"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBE"},"designation_date":{"value":"2022-10-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.574320316314697}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBG","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBG"},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBH"},"designation_date":{"value":"2022-11-16"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBM","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBM"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBN","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBN"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBP","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBP"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBR"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBS"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBT"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5037920175803539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBQ"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBY","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBY"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBW"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBV"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBZ","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBZ"},"designation_date":{"value":"2023-03-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBU","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBU"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCB"},"designation_date":{"value":"2023-04-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCA"},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XCC","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCC"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCD"},"designation_date":{"value":"2023-06-08"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCE"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCG"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCJ"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCL","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCL"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCK","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCK"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCM","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCM"},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCN"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCP","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCP"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCQ","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCQ"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCR","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCR"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCS","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCS"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCU","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCU"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCV"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCY","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCY"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCW","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCW"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XDB","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDB"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XCZ","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCZ"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XDC","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDC"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDE"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDF"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDH"},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDJ","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDJ"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDG"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDM","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDM"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDN","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDN"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDL","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDL"},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDS","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDS"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDS"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDU","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDU"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9475349114594978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDT"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDY","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDY"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDW"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XDZ","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDZ"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XE","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XE"},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEB","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEB"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEB"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEA","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEA"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2268340125514634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XED"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":17.361},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XED"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEF","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEF"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":34.028},"immune_escape":{"value":"1.7268345560655398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEG"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":950.694},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEE","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEE"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEE"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.013909339904785}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XG"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XG"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XJ","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XJ"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XH","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XH"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XL","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XL"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XK","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XK"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XM","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XM"},"designation_date":{"value":"2022-03-31"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XM"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.148608207702637}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XN","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XN"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XN"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.339982509613037}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XR","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XR"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XT","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XT"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.084201812744141}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XP","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XP"},"designation_date":{"value":"2022-04-01"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3616394203564539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.0015506744384766}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XQ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XQ"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.572240829467773}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XW","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XW"},"designation_date":{"value":"2022-05-12"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XW"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XV","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XV"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.536291122436523}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XU","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XU"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XU"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XZ","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XZ"},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XZ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.089031219482422}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XY"},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"partiallyAliased":{"value":"XBK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"partiallyAliased":{"value":"XCH"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH.1"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9920809268951416}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"partiallyAliased":{"value":"XCT"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT.1"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"partiallyAliased":{"value":"XDA"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA"},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"partiallyAliased":{"value":"XEC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC.1"},"designation_date":{"value":"2024-08-14"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":29.34},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":34.028},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.1"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}},{"name":"XCF.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.2"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.1"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.2"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"partiallyAliased":{"value":"XDR"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"partiallyAliased":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.2"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}},{"name":"XDR.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.1"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.2"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.1"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"partiallyAliased":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.083851337432861}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.083851337432861}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49430513381958}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.2"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.3"},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1974196434021}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"partiallyAliased":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.3"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.4"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.2"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"internal_63f4","node_attrs":{"div":37,"partiallyAliased":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.3"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"partiallyAliased":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"partiallyAliased":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.3"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.5"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XDK.4.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.6"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":61,"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"NODE_0000033","node_attrs":{"div":62,"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.10","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.10"},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.10"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.2943291664123535}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.9","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.9"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.9"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"partiallyAliased":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116386413574}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116386413574}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1.1"},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"partiallyAliased":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"partiallyAliased":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":53,"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY"},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":53,"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.3"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":56,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":57,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1506476402282715}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.997220516204834}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":58,"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1506476402282715}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.697917461395264}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}},{"name":"XAY.2.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":60,"partiallyAliased":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.2"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":62,"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000046","node_attrs":{"div":63,"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":64,"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":65,"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.682617664337158}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.2","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}},{"name":"GL.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752889267417711"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.494446754455566}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"partiallyAliased":{"value":"XDV"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"partiallyAliased":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.10"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.11"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.3"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.5"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5359962252743784"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14808999999999992"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.4","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.4"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.8"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"partiallyAliased":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":6.25},"immune_escape":{"value":"1.8051577060608006"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26874999999999993"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}},{"name":"XDV.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000052","node_attrs":{"div":60,"partiallyAliased":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5422010449483097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20783000000000001"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]},{"name":"NODE_0000053","node_attrs":{"div":61,"partiallyAliased":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7"},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24D"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":68,"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC"},"designation_date":{"value":"2022-09-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":68,"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.2.1"},"designation_date":{"value":"2023-03-19"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.44507236664312827"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}},{"name":"XBC.2","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"XBC.2"},"designation_date":{"value":"2022-10-14"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"totalAminoacidSubstitutions":{"value":58},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}}]},{"name":"NODE_0000057","node_attrs":{"div":70,"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"XBC.1"},"designation_date":{"value":"2022-10-03"},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"totalAminoacidSubstitutions":{"value":57},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.187767505645752}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":76,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.4"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":75,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.5"},"designation_date":{"value":"2023-02-26"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000059","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":78,"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":79,"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1.1"},"designation_date":{"value":"2023-01-07"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48837241784414276"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.1.2"},"designation_date":{"value":"2023-06-10"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":76,"partiallyAliased":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":76,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7"},"designation_date":{"value":"2023-06-10"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7.1"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.7.2"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":72,"partiallyAliased":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":78,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":79,"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.1","node_attrs":{"div":80,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.2"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.3","node_attrs":{"div":81,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.3"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":83,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.3.1.4"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":84,"partiallyAliased":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":84,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6"},"designation_date":{"value":"2023-03-16"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.2"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":87,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.4"},"designation_date":{"value":"2023-06-14"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.4"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":88,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.5"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.5"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":85,"partiallyAliased":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":88,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.1.1"},"designation_date":{"value":"2023-06-14"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":85,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.1"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":87,"partiallyAliased":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":89,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.6.1"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7550301657183831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"JT.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":87,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.6"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":86,"partiallyAliased":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":86,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3"},"designation_date":{"value":"2023-04-23"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":89,"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.2","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.2"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1"},"designation_date":{"value":"2023-08-02"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":90,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"designation_date":{"value":"2023-10-13"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.3"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}},{"name":"HW.1.1","node_attrs":{"div":92,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"designation_date":{"value":"2023-08-02"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420325830319254"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.1"},"clade_who":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"clade_membership":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.349863529205322}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.9"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0810114368008295"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26627999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}},{"name":"XBB.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3064099999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000075","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.7"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000077","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000078","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.1"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.2"},"designation_date":{"value":"2023-06-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000079","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.2"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.4"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.5"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000080","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.3"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}},{"name":"XBB.3.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122062683105469}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122062683105469}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.12"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.4"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.165234565734863}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.9"},"designation_date":{"value":"2023-05-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54503870010376}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.8"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.256869792938232}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"internal_619ad3bd","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143047332764}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143047332764}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11.1"},"designation_date":{"value":"2023-06-11"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65097"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000084","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.83268404006958}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.10"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000085","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.1"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.2"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000086","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.2"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.3"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.6","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000087","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067752838134766}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35217"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35217"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067752838134766}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000088","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.583855628967285}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.14"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.900240898132324}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.18"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2567103717994188"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0750199999999999"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.20"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.21"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.22"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.5"},"designation_date":{"value":"2023-04-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84876"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.42367696762085}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.7"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.456076145172119}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.9"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675187587738037}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.92117"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.92117"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675187587738037}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343238830566}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13359999999999994"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.8618388175964355}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343238830566}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.036584854125977}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0527558336884004"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84789"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.918221950531006}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90647"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.901963710784912}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.16"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.84876"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.17"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89912"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.88039"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.88039"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6"},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736186906064397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89932"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}},{"name":"GM.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647790908813477}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647790908813477}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000102","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0079043361863298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7709600000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.985507965087891}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.762627124786377}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000104","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.607783317565918}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.551803112030029}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}},{"name":"GS.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000106","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651515960693}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651515960693}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030636310577393}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030636310577393}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.517807483673096}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704747676849365}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704747676849365}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.6","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"designation_date":{"value":"2023-10-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000112","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.451866626739502}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"internal_bb69915a","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103416442871}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103416442871}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.436974048614502}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.436974048614502}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.918066501617432}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.918066501617432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000118","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.826663017272949}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.56931734085083}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"internal_d2763520","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000120","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.986824739722089"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.70075"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000121","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000123","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95933"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000124","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.257803916931152}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.257803916931152}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000125","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.203644752502441}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13359999999999994"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GJ.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"designation_date":{"value":"2023-06-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000131","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89912"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.32551383972168}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.32551383972168}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000135","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734275817871}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734275817871}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.75251"},"clade_membership":{"value":"23E"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.842318534851074}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_XBB1_out","node_attrs":{"div":27,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.060752868652344}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.060752868652344}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.10"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13558"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.3"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49564"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.381250858306885}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000137","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980052947998}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.33"},"designation_date":{"value":"2023-04-18"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0545"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.49"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89405"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.542015552520752}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.20"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.48"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.9722600000000003"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000139","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.2"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"XBB.1.19","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000141","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000142","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000143","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000144","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000145","node_attrs":{"div":54,"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.2","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"internal_ORF8stop","node_attrs":{"div":28,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1269187927246094}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.21"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86729"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.27"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2602599999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.29"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.36"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3860321044921875}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.40"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.7"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.885027885437012}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.6"},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.8"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000147","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12"},"designation_date":{"value":"2023-02-09"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12.1"},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}},{"name":"XBB.1.13","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18493000000000007"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000149","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926177978515625}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926177978515625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.37.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43.1"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.43","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211505889893}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211505889893}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306163787842}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.45","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306163787842}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000156","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.1"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.2"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.54089"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4"},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.1"},"designation_date":{"value":"2022-11-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9892516136169434}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.2"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34"},"designation_date":{"value":"2023-04-20"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000160","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296717643737793}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.30"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.751910209655762}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.39"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.072850227355957}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32.1"},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.578298091888428}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05231"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000163","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"FW.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.094683647155762}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1"},"designation_date":{"value":"2023-05-01"},"frameShifts":{"value":"ORF6:3-62"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000165","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}},{"name":"FW.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"designation_date":{"value":"2023-08-22"},"frameShifts":{"value":"ORF6:3-62"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13254"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.714374542236328}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547362804412842}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.98364782333374}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000169","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000170","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7388600000000002"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296717643737793}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.080835342407227}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.2"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.35"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.46"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.2145609855651855}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47.1"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000173","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05408"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000174","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.77537202835083}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"NODE_0000179","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"HE.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65784"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.2"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1099290580037755"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6066099999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.65784"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000183","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JW.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000185","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.68441104888916}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000186","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"internal_b1afb4e5","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.43418"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.51123"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.2"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"XBB.1.17","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000190","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.111379623413086}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.10","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"GA.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000191","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GA.10.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"designation_date":{"value":"2023-12-03"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","G13822A","A19307G","G22927T","T22928C","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["V119I","K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: V119I, K1947R; ORF9b: T95M; S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"GA.2.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80721"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","T6640C","C9857T","C10279T","A12235G","A22910G","G23222A","A25927T","C29002T"],"ORF1a":["M85-"],"ORF3a":["I179F"],"S":["N450D","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF3a: I179F; S: N450D, E554K","spike_mutations":"N450D, E554K"}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GA.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000194","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.96117"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000195","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90647"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000196","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5"},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.110"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.110"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.22"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.23"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.43"},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.543598651885986}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.45"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.57"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.463161468505859}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.58"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.87"},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.87"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93509"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873941659927368}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873941659927368}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2755987644195557}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.10"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.101"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.101"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.104"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.104"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.082747936248779}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.105"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.105"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.109"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.109"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.108"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.108"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.12"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.64321231842041}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.11"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.960800886154175}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.18"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7349727153778076}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.2"},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.002401351928711}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.28"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8485686779022217}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.29"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41404999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.31"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.887559652328491}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.34"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.28225564956665}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.35"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.06293249130249}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.33"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.639432191848755}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.36"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.254280090332031}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.40"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95377"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.198355674743652}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.52"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8478691577911377}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.51"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.54"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.59"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.106780052185059}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.63"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7503247261047363}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.64"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.169807434082031}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.62"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.189828872680664}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.66"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.67"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.767808198928833}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.69"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266829013824463}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.75"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.79"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.656114101409912}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.80"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.80"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.27465295791626}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.82"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.82"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.91194"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.85"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.85"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.914321422576904}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.97"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.97"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.99"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.99"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.98"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.98"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000202","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.174045562744141}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14"},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762266635894775}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.809102535247803}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762266635894775}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1023732112409157"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29094"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41123000000000004"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.282759666442871}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.728201150894165}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85055685043335}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3"},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.728201150894165}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456169128418}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456169128418}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994797945022583}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"designation_date":{"value":"2024-01-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994797945022583}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.50"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.71"},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48403999999999986"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"GC.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.03073601411565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9061"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.989251613616943}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.297218322753906}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.297218322753906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.091250896453857}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7416800000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.73864"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.285966396331787}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.285966396331787}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.830754280090332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.99921178817749}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}},{"name":"HS.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.830754280090332}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020680904388428}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1186099999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5119218826293945}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020680904388428}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}},{"name":"FZ.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}},{"name":"HZ.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.319439888000488}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}},{"name":"HC.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576805830001831}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0346353162114479"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9873000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.174569606781006}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576805830001831}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5.26"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054046630859}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9577000000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054046630859}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5237400000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3490142822265625}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.842705249786377}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"GN.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3490142822265625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889133453369}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889133453369}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{}}},{"name":"KK.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2868306565498102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.20635"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"KK.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}}]},{"name":"NODE_0000244","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376293182373}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3046787170970133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1261900000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.11","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.10","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70"},"designation_date":{"value":"2023-05-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GK.5.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704257965088}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"GK.3.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.486576080322266}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"NODE_0000251","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.8981300000000001"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.89509"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136261463165283}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136261463165283}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}},{"name":"GK.1.11","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.6.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}},{"name":"GK.1.8","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000259","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":51,"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3541583181563797"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.1446400000000003"},"clade_membership":{"value":"23G"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.4131407737731934}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.106"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.106"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.19"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062247276306152}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.20"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6764075756073}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.25"},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.187679290771484}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.27"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.515899181365967}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.32"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6741185188293457}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.37"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5378670692443848}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.5"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0984206199646}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.56"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.201076507568359}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.6"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.60"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.624792098999023}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.61"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265188694000244}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.65"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8305227756500244}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.72"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7908682823181152}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.74"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0169257119491577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9630099999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.76"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.102418422698975}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.8"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.449068546295166}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.78"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.81"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.81"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.6281256675720215}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.83"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.83"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.545153617858887}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.84"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.84"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2501959800720215}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.88"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.88"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.298462390899658}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.9"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.89"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.89"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.91"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.91"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.224147319793701}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.90"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.90"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.96"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.96"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.111899375915527}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.94"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.94"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.447929859161377}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"NODE_0000263","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.83085"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0655517578125}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689449310303}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.135179042816162}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689449310303}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000266","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9838451476656441"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.83156"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93473"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237003326416}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9350799999999999"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46"},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237003326416}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000271","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8168466091156006}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.310755729675293}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49"},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8168466091156006}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.5945"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.5945"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]},{"name":"NODE_0000274","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.74111"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.124101638793945}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}},{"name":"FT.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0924169334128189"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74638"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89299"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}},{"name":"FD.4","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"NODE_0000283","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038018703460693}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}},{"name":"FD.5","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23A"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038018703460693}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.754912853240967}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.25"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.5613484382629395}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.26"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.335569381713867}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.2106804847717285}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.2106804847717285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.3"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.79517126083374}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.79517126083374}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.950188045949472"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86018"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9788766097021935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.67693"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"NODE_0000288","node_attrs":{"div":32,"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652244567871}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652244567871}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388861179351807}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}},{"name":"FY.6.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8926499999999999"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}},{"name":"FY.8.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80106"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.80106"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"internal_77ad61e0","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"designation_date":{"value":"2023-09-06"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74983"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"FY.5.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3639702796936035}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3639702796936035}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}},{"name":"FY.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000304","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"NODE_0000305","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.9962849617004395}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16"},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.9962849617004395}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.10","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.10"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.275190353393555}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.12"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.11"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.181058406829834}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.14"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7388600000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.17"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.19"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.18"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.089405059814453}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.16"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.20"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.22"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.21"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.24"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.23"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.26"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1827216148376465}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.25"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.27"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.28"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.4"},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.5"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.7"},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.9"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.8"},"designation_date":{"value":"2023-05-26"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"NODE_0000307","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"KJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.64385"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.64385"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15"},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.29"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.30"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.31"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.640304088592529}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"HF.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121833324432373}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8289546966552734}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000315","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}},{"name":"JF.1.1.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.412325859069824}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.5","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"FU.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.14642"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.412325859069824}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000319","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}},{"name":"FU.1.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":41,"partiallyAliased":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.968926429748535}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8164899999999998"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.5","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"GY.7","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.968926429748535}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"GY.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.2326700000000002"},"clade_membership":{"value":"23B"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.09678840637207}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.23"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.1"},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1416096687316895}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.42","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000327","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191345691680908}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.941244125366211}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"22F"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191345691680908}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"partiallyAliased":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.4"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.5"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.6"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13558"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.7"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000329","node_attrs":{"div":33,"partiallyAliased":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036271572113037}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.6875"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.331241607666016}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40686999999999995"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036271572113037}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":34,"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927202224731445}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.12","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.064052581787109}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.11","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.14","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.2342681884765625}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.532744884490967}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.27","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.29","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7904599999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.217490196228027}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.6","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.7","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927202224731445}},"branch_attrs":{"mutations":{}}},{"name":"internal_d2a6176a","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.459027290344238}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9957660361777405"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0848"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}},{"name":"FL.26","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.459027290344238}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90046"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.90046"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"NODE_0000336","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431282043457}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431282043457}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.516284465789795}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.887217044830322}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.919838905334473}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.35","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.887217044830322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.1391448974609375}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.1391448974609375}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81109"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747514724731445}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}},{"name":"FL.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747514724731445}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.97144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.17","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}}]},{"name":"NODE_0000342","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299052715301514}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299052715301514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.398621082305908}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.20.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5920999999999998"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}}]},{"name":"internal_10251222","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342810153961182}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1216394663867173"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.98073"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342810153961182}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.3","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000347","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8835"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"FL.23.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.96117"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.066182613372803}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}},{"name":"FL.3.2","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282451629638672}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282451629638672}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.47537999999999986"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_566a3ed0","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_69bba568","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376365661621}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376365661621}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":35},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07635999999999983"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}},{"name":"FL.13.4","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.67327356338501}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"designation_date":{"value":"2023-05-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000356","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1684T","C11747T","C29236T"]}}},{"name":"FL.15.4","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}}}]},{"name":"NODE_0000358","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G6819A","G22927T"],"ORF1a":["T2007I","S2185N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I, S2185N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000359","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]},{"name":"NODE_0000361","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.463090896606445}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.671279430389404}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8957390785217285}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.00936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"FL.2.3","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.854552745819092}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.2.7","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_95ea4775","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4.10","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.888331413269043}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.11","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.458424091339111}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93509"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.9","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"FL.4.7","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.97144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"internal_12061207","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0186868047371063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48144"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3348299999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000368","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"NODE_0000369","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.3","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78812"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}},{"name":"FL.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.854552745819092}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9778643306477401"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.89211"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000372","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000373","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"designation_date":{"value":"2023-08-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.06800999999999986"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000374","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.15393000000000004"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000375","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.36653995513916}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000376","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000377","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3005141566416802"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0007299999999998658"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000378","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232714653015137}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000379","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254451751709}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254451751709}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.009539999999999936"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]},{"name":"NODE_0000380","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"HN.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"NODE_0000381","node_attrs":{"div":35,"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.61879825592041}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.13","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.12","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.14","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.7","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1186099999999999"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.61879825592041}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17686"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}},{"name":"EG.9","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.20938"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17686"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616470336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000384","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1256300000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}},{"name":"EG.10.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1256300000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919017791748}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919017791748}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000386","node_attrs":{"div":39,"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8845162391662598}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8845162391662598}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"designation_date":{"value":"2023-09-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07635999999999983"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000387","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.092266082763672}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.092266082763672}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.5","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.041689999999999984"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.86275"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8657900000000001"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EG.4.3","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.4","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.310484886169434}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000390","node_attrs":{"div":37,"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541389226913452}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1.2","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.1","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541389226913452}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.7","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.121776580810547}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.6","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.5","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.570929050445557}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}},{"name":"EG.1.4","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0124"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":40,"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173191070557}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000393","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"NODE_0000394","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0384697914123535}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.64849853515625}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23D"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000395","node_attrs":{"div":42,"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747878074645996}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747878074645996}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.772064208984375}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.292908191680908}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.374487400054932}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621211528778076}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.585853576660156}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000399","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"designation_date":{"value":"2023-11-29"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4312755323086508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.73257"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000400","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000401","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":44,"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.504891872406006}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.471978664398193}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000403","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.4253100000000001"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.9912302494049072}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.3","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8333635330200195}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3.4","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.5133399999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000404","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735766887664795}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735766887664795}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000405","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068490982055664}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068490982055664}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3341105633249508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.0887599999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.10","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.025979999999999802"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8597540855407715}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.4","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.5","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.401525974273682}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.3","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3005451981781486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21974"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.8","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.7","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.9","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043656826019287}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.048559999999999943"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3552393372267753"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.38161000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.412596225738525}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000407","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000408","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":53,"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.008039999999999839"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000410","node_attrs":{"div":45,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1972306507819483"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.13706999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.19","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.18","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.14733999999999992"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.21","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.205901853206978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.1481699999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.310148541751831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.49366"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"designation_date":{"value":"2023-11-27"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.29","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.267586708068848}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.28","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.32","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.31","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.25141716003418}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.30","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.5","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.4","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.7","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2183176254438959"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.6088199999999999"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000417","node_attrs":{"div":51,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3534097328298118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.48614000000000007"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000421","node_attrs":{"div":48,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.570084095001221}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HK.27.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18525999999999987"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.213572025299072}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.213572025299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000425","node_attrs":{"div":50,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.15","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.9","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18829999999999997"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8.1","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.64849853515625}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"HK.8","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23F"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366167068481445}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3.10","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366167068481445}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.934603691101074}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.4","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.7","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.5","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.9","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.3123884201049805}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_membership":{"value":"23H"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0657408237457275}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.16","node_attrs":{"div":1,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.16"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.231195449829102}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.15"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.830538272857666}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.19"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.504542827606201}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"partiallyAliased":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2791748046875}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87.1","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87.1"},"designation_date":{"value":"2024-02-01"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":41},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6657453429914796"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8217399999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}},{"name":"BA.2.87","node_attrs":{"div":1,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2791748046875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.703927040100098}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3"},"designation_date":{"value":"2021-12-14"},"totalAminoacidSubstitutions":{"value":44},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.8266096115112305}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1"},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.807485044002533}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.9166173934936523}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.1350862979888916}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000435","node_attrs":{"div":63,"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8540998697280884}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8540998697280884}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000436","node_attrs":{"div":66,"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066323280334473}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066323280334473}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":83,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2"},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.5603076219558716}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E156-","F157-","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"B","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B"},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{}}},{"name":"A","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A"},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.stopCodons.totalStopCodons":{"value":0},"clade_display":{"value":"outgroup"},"Nextclade_pango":{"value":"A"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.945819139480591}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}}]}]}]}]}]}]},{"name":"NODE_0000438","node_attrs":{"div":1,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4824707508087158}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.1"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.958989143371582}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.11"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.020416736602783}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.18"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.061755418777466}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.20"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9340524673461914}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.24"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.01261797446067892"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0435516834259033}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.27","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.27"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9488906860351562}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.28","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.28"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.955256462097168}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.29"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.246367931365967}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.26","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.26"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5775980949401855}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.32","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.32"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7237727642059326}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.30","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.30"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.182343006134033}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.39","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.39"},"designation_date":{"value":"2022-05-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.341081619262695}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.41","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.41"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7299158573150635}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.43","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.43"},"designation_date":{"value":"2022-05-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11284999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.410249710083008}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.4","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.4"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7205681800842285}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.42","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.42"},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.5","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.5"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.587897777557373}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.46"},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.784327030181885}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.48","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.48"},"designation_date":{"value":"2022-06-01"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.789991855621338}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.50"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.21274471282959}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.55"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.215762615203857}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.59","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.59"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.600702285766602}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.54","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.54"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.1376729011535645}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.58"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.052984714508057}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.61","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.61"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.49704647064209}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.62"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.998417377471924}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.63","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.63"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172097206115723}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.64","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.64"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5229692459106445}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.60","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.60"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.65","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.65"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8462483882904053}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.70","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.70"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.472927093505859}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.77"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3221048136122174"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9213199999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.581743240356445}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.82","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.82"},"designation_date":{"value":"2022-08-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.82"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.2169976234436035}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.8","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.8"},"designation_date":{"value":"2022-03-28"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3260767459869385}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.83"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.22071783986880583"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.83"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.12534"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.85"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.85"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.299956321716309}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000439","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565171957015991}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565171957015991}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2.1"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000440","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1333484649658203}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1333484649658203}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23.1"},"designation_date":{"value":"2022-05-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8213231563568115}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.867221832275391}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.31","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8213231563568115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000442","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8927619457244873}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.35","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.35"},"designation_date":{"value":"2022-04-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.570833206176758}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.33","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.33"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086804389953613}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797025442123413}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797025442123413}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40.1"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7479588985443115}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000444","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9644880294799805}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56"},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9644880294799805}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56.1"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.697122097015381}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"BA.2.10_internal","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636719226837158}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636719226837158}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.2"},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.685617685317993}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.3"},"designation_date":{"value":"2022-05-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.080300331115723}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.4"},"designation_date":{"value":"2022-08-09"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3166622371297313"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.73328"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.095381259918213}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.472888946533203}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1"},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.472888946533203}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1.1"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6181860283242497"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.09519000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000447","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.6233313083648682}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.14"},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.639008045196533}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.22"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2793376445770264}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.36"},"designation_date":{"value":"2022-05-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.069880962371826}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.34","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.34"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.04110860824585}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.45","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.45"},"designation_date":{"value":"2022-05-23"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.638923168182373}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.49","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.49"},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7811052799224854}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.47","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.47"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.130137920379639}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.52","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.52"},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8808929920196533}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.51","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.51"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6952691078186035}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.53","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.53"},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.6","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.6"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6632723808288574}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.69"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9400291442871094}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.71","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.71"},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.660404682159424}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.7","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.7"},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.356358766555786}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.72","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.72"},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6165003776550293}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.80"},"designation_date":{"value":"2022-07-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.31190394480802347"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.80"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10838000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6450419425964355}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.81"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.81"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.347171783447266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.490032196044922}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.490032196044922}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25.1"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.996252536773682}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.739166498184204}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.44"},"designation_date":{"value":"2022-05-21"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11284999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.218892574310303}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5540249347686768}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13.1","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13.1"},"designation_date":{"value":"2022-07-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.024052619934082}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}},{"name":"BA.2.13","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13"},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5540249347686768}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.19162917137146}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.19162917137146}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.2"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6204254627227783}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.4"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.284677505493164}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.5"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.238983154296875}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.1","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.1"},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.3"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.352891683578491}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.7"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.828467607498169}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.6"},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.504576683044434}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}}]}]},{"name":"BA.2.3_internal","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485034465789795}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.10","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.10"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.098453044891357}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3"},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485034465789795}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.1","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.1"},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.11"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.797952890396118}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.13"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.348180055618286}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.14"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9584250450134277}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.17"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.899256467819214}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.15"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8729326725006104}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.12"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.18"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.462869644165039}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.19"},"designation_date":{"value":"2022-07-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.702392578125}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.5"},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.302077293395996}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.4"},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.8"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.9"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8521361351013184}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.7"},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020241260528564}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"internal_305a","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43687237373984505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9456899999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601465225219727}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06758"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.848114013671875}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4733677107846063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"DD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9683399999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000455","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.171501159667969}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.22"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.42289430257523936"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.37526000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.6"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.009505271911621}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9327023029327393}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2"},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9327023029327393}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000457","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4975483601650658"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66821"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}},{"name":"BS.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1"},"designation_date":{"value":"2022-09-12"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.49181526572268314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66194"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"designation_date":{"value":"2022-09-30"},"frameShifts":{"value":"ORF6:34-62"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6029918987948071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6589000000000002"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_a315","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666072845459}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666072845459}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.10"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7593324873420084"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.8190299999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000459","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7016283989012374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.91683"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"CM.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8143059671640498"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9440299999999998"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}},{"name":"CM.6","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_7ac4","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7255583352017505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.99403"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000463","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000464","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000465","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.17483999999999994"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0761544902802131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"FV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.28625999999999996"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.12"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.11"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0179803928276123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35566999999999993"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.29833"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.9"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"CM.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.06344"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000468","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287181854248}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000469","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24425000000000008"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9785485534494837"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9729599999999999"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":2,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.128720760345459}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.17"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.112698078155518}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.21"},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9177675247192383}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.37"},"designation_date":{"value":"2022-05-03"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1007766723632812}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.57"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.16643762588501}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.68","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.68"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.936066150665283}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.66","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.66"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.675917148590088}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.74","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.74"},"designation_date":{"value":"2022-06-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.33134042675697756"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21698000000000003"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.888683795928955}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.73","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.73"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.040534496307373}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.78","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.78"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.10556"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.664737701416016}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000471","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0960655212402344}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.67"},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000472","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79.1"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000473","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6619465351104736}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76"},"designation_date":{"value":"2022-07-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6619465351104736}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000474","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.1"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.2640232066165751"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.18492"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}},{"name":"BA.2.76.2","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.2"},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.11142000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.444322347640991}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38"},"designation_date":{"value":"2022-05-06"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.23107"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.444322347640991}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"partiallyAliased":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.7409892082214355}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3"},"designation_date":{"value":"2022-08-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.07383293656037815"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.08445999999999997"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.7409892082214355}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3.1"},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.370455061085298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.580890655517578}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000477","node_attrs":{"div":3,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9894256591796875}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.1"},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086116313934326}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000478","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.909890174865723}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.2"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.319439888000488}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.4"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07569000000000004"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.4497761726379395}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"partiallyAliased":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7863521575927734}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7863521575927734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.2"},"designation_date":{"value":"2022-06-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.062348652344665065"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.07350000000000005"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9584996700286865}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.057555675506592}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.057555675506592}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000481","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292704820632935}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.1"},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.2"},"designation_date":{"value":"2022-06-18"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0345394611358643}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.4","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.6","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.6"},"designation_date":{"value":"2022-08-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}},{"name":"BG.5","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.5"},"designation_date":{"value":"2022-07-28"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.7","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.7"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.3","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_membership":{"value":"22C"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.862102746963501}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.862102746963501}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.10"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.499692916870117}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.7"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.544760227203369}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.8"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04854"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81858"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.514627456665039}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.13451"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000485","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7472099999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7472099999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.37898588180542}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.3"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5588825437629772"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.24593"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000487","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9449499999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9449499999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7451886007636047"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.12575999999999996"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000488","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.4"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5013910005227346"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.10514"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000489","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5"},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03573"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03573"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}}]}]}]}]},{"name":"NODE_0000490","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100636959075928}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100636959075928}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.4"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000491","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210721492767334}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.5"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.16854"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"BL.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.3"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"NODE_0000492","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590966701507568}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.043233394622803}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}},{"name":"BL.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590966701507568}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000493","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.178379535675049}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.178379535675049}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.19193"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.3464399999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6011952983295785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.56756"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.973597526550293}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.1.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.6"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5544855553668998"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.11979"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.6811747550964355}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.6811747550964355}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275516986846924}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275516986846924}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_147e","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41646999999999995"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263591289520264}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2"},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263591289520264}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.41646999999999995"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.716527938842773}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.4","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.4"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.6"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"CA.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.7"},"designation_date":{"value":"2022-10-24"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.5"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2371799999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.580175399780273}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}},{"name":"CA.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000500","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096987247467041}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096987247467041}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.4"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14197"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.784380912780762}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.6"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.5"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227935791015625}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1724299999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227935791015625}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14197"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488797664642334}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5060716304521155"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.11385"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488797664642334}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.653690335850791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.9134323596954346}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}}]},{"name":"NODE_0000503","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420084476470947}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420084476470947}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.11","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.977697372436523}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.8","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9193315170816834"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5340599999999999"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.7","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"NODE_0000504","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.2021600000000001"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.2021600000000001"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000505","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842318534851074}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7815531080803261"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.31233"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}},{"name":"BN.1.5.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7470314258752732"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.1331"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]}]},{"name":"NODE_0000507","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000508","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735761642456055}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.108586311340332}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}},{"name":"BN.1.4.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.1361188888549805}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"designation_date":{"value":"2022-11-28"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.22015380859375}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000510","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.501852035522461}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.501852035522461}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.775949239730835}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7326886306518271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.21326"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.376982688903809}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"NODE_0000511","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000512","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1.2","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.3","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000513","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.4","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}},{"name":"FR.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}}]}]}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563655376434326}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563655376434326}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4979681968688965}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.060053825378418}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0513083167390975"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.16291"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}},{"name":"DS.3","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.12","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.114459037780762}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"designation_date":{"value":"2023-03-30"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.856032848358154}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.576071739196777}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.082351207733154}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.3","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"designation_date":{"value":"2023-08-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08629"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"designation_date":{"value":"2023-02-02"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.791740894317627}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.25339"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.041548728942871}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000520","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307618141174316}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307618141174316}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.3"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301943778991699}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.6","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.6"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15852"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"BM.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.5"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15852"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.031525135040283}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000521","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.052262306213379}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.28689"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.052262306213379}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5272935807019111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.26994"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.548510551452637}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.78817"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.174620628356934}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}},{"name":"BM.2.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.81858"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.425735950469971}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1"},"designation_date":{"value":"2022-08-30"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.425735950469971}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78306245803833}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78306245803833}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000525","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458258628845215}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}},{"name":"BM.1.1.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}}]},{"name":"NODE_0000526","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.028015613555908}},"branch_attrs":{"mutations":{"nuc":["C3130T","C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.028015613555908}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42674000000000006"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"designation_date":{"value":"2022-12-06"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000527","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","C3130T","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.46466000000000013"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000528","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.46466000000000013"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000529","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000530","node_attrs":{"div":39,"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.42369999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]},{"name":"internal_f6c6","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.266562461853027}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.43724"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.266562461853027}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273096084594727}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273096084594727}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000533","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"designation_date":{"value":"2022-12-14"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9457248359372292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.87567"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.26216459274292}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000534","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}},{"name":"CJ.1.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04277"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539737701416016}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.17547"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539737701416016}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628327369689941}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35628"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628327369689941}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506646633148193}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506646633148193}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4677"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000538","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852518558502197}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.07323"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"CH.3.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.0219999999999998"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7685109779549473"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36891999999999997"},"clade_membership":{"value":"22D"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000541","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000542","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.21","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":1},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"designation_date":{"value":"2023-03-29"},"frameShifts":{"value":"ORF7a:59-122"},"totalAminoacidSubstitutions":{"value":69},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.9441222497200389"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.08511000000000003"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}},{"name":"CH.1.1.18","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}}]},{"name":"NODE_0000543","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000544","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1.1","node_attrs":{"div":37,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9334899999999999"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}},{"name":"GQ.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9334899999999999"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000545","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.328583240509033}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8057045936584473}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0050458908081055}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"internal_ddb1","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000547","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363282680511475}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363282680511475}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000554","node_attrs":{"div":40,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000555","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":48,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000558","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000559","node_attrs":{"div":41,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.3","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.05117"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000560","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000561","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000562","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000563","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462226867676}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"designation_date":{"value":"2023-01-13"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000564","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000565","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000566","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000567","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"designation_date":{"value":"2023-09-24"},"frameShifts":{"value":"ORF7a:62-122"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"designation_date":{"value":"2023-12-01"},"frameShifts":{"value":"ORF7a:62-122"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.05667"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000569","node_attrs":{"div":32,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"designation_date":{"value":"2023-03-31"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000571","node_attrs":{"div":33,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000573","node_attrs":{"div":37,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.3224663734436035}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"designation_date":{"value":"2023-04-13"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.3224663734436035}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9815994835819151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.16085999999999998"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000576","node_attrs":{"div":43,"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32796"},"clade_membership":{"value":"23C"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000577","node_attrs":{"div":50,"partiallyAliased":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.661655902862549}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86"},"designation_date":{"value":"2023-08-17"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.661655902862549}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.5"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.4"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"NODE_0000578","node_attrs":{"div":52,"partiallyAliased":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}},{"name":"LV.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.2"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}}]},{"name":"NODE_0000579","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7"},"designation_date":{"value":"2024-06-13"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000580","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.6738025507980547"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000581","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.1"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000582","node_attrs":{"div":56,"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2"},"designation_date":{"value":"2024-03-05"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.15919"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000583","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"designation_date":{"value":"2024-03-20"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000584","node_attrs":{"div":52,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.782770156860352}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.4"},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.518976211547852}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000585","node_attrs":{"div":53,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.8259432315826416}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1"},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.8259432315826416}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.12"},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.14","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.14"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.16","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.16"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.17","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.17"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.15","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.15"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.18","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.18"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.01167631149292}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.19","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.19"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.808485507965088}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.6"},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.8","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.8"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.7","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.7"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.9"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"NODE_0000586","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11"},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000587","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13"},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000588","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5"},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6465599999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000589","node_attrs":{"div":55,"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.34682559967041}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.34682559967041}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000590","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"ORF1a":["P892S"]},"labels":{"aa":"N: H300Y; ORF1a: P892S"}},"children":[{"name":"JN.3.2","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2850199999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]}]},{"name":"internal_59b29264","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":54,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2"},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.4","node_attrs":{"div":57,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.3","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.5","node_attrs":{"div":56,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000592","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04777"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000593","node_attrs":{"div":54,"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.369624137878418}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.10"},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.32843999999999995"},"clade_membership":{"value":"23I"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.50243616104126}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000594","node_attrs":{"div":58,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7884089946746826}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1"},"designation_date":{"value":"2023-09-29"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7884089946746826}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.408935546875}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.26806999999999986"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217947959899902}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9045872688293457}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062774658203125}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.875373840332031}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.674196720123291}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.493675231933594}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491053104400635}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407819747924805}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.03013801574707}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.296980381011963}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.23248815536499}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.804255247116089}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.117530822753906}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.341228008270264}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.62","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"designation_date":{"value":"2024-06-08"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.61","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.496607246855186"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.93036"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407478332519531}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.66","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086578369140625}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.971951007843018}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086578369140625}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240832328796387}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"designation_date":{"value":"2024-02-20"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.21099"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240832328796387}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.23.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.21099"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012979507446289}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3227739334106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012979507446289}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.162879467010498}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.261645793914795}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"JN.1.32","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.162879467010498}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844123840332031}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844123840332031}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.38.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.390693187713623}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}},{"name":"JN.1.43","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.390693187713623}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741860389709473}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.848097324371338}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.44","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741860389709473}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.473700046539307}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.473700046539307}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.532734695870142"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.05681999999999991"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906609058380127}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5395016697354735"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7602899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906609058380127}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2344651222229}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2344651222229}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.492700099945068}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803304672241211}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803304672241211}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":8.507},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"NODE_0000606","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1652140617370605}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1652140617370605}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7444634437561035}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.048468589782715}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.048468589782715}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250581741333008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250581741333008}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395020484924316}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395020484924316}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341370105743408}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341370105743408}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"designation_date":{"value":"2024-07-10"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4552719593048096}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.33223295211792}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.33223295211792}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.063129425048828}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005730152130127}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.993558406829834}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005730152130127}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4039130210876465}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4039130210876465}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.081502914428711}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.081502914428711}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.51407527923584}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.51407527923584}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.771152973175049}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.627852916717529}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}},{"name":"JN.1.55.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}}]}]},{"name":"NODE_0000618","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.6971025466918945}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.6971025466918945}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000619","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.189657688140869}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.189657688140869}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.898664951324463}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.853456020355225}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"JN.1.39","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.898664951324463}},"branch_attrs":{"mutations":{}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1753339767456055}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.563376426696777}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655728340148926}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"designation_date":{"value":"2024-04-02"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.302780628204346}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"JN.1.42","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"designation_date":{"value":"2024-03-25"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655728340148926}},"branch_attrs":{"mutations":{}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"designation_date":{"value":"2024-05-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"designation_date":{"value":"2024-08-15"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"designation_date":{"value":"2024-05-18"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"ME.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.27215999999999985"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.891266345977783}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.891266345977783}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834461688995361}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834461688995361}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000628","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2595099999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343695163726807}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343695163726807}},"branch_attrs":{"mutations":{}}},{"name":"internal_dafb7842","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5484747886657715}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5484747886657715}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693490982055664}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.124732494354248}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688722133636475}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566845893859863}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.104548454284668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"NODE_0000637","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000639","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.500879287719727}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.500879287719727}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000640","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438821315765381}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.6234025955200195}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000641","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617192268371582}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617192268371582}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.780251502990723}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.780251502990723}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424532413482666}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424532413482666}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753118515014648}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.045562267303467}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"designation_date":{"value":"2024-08-20"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.396651744842529}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000647","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.625002384185791}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.625002384185791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000648","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000649","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3745641202332524"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.9318500000000001"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000650","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"designation_date":{"value":"2024-04-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000651","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772459506988525}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.320776462554932}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772459506988525}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.515129089355469}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000655","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.30217999999999995"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000657","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.307804584503174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.224503517150879}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.58","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.307804584503174}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.408945083618164}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872630596160889}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872630596160889}},"branch_attrs":{"mutations":{}}},{"name":"LR.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}},{"name":"LR.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.4686198234558105}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.532440185546875}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.532440185546875}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.34312105178833}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.34312105178833}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.9152421951293945}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.9152421951293945}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.229276180267334}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005531311035156}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.02389"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.469202041625977}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.105811595916748}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.09798002243042}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309722900390625}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309722900390625}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.690683841705322}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.175650596618652}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.08313"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.566635608673096}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000671","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000672","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347302436828613}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347302436828613}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.04395"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.99325704574585}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.95433"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.99325704574585}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.711982011795044}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.776760578155518}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.711982011795044}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.743708610534668}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924505710601807}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924505710601807}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000677","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.816462993621826}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0927324295043945}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.036890506744385}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"designation_date":{"value":"2024-02-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685323238372803}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685323238372803}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782630443572998}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782630443572998}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.02389"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000681","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769372940063477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769372940063477}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145790100097656}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000682","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3.1","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}},{"name":"LE.1.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5281498432159424}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5281498432159424}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21984999999999988"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000684","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642734527587891}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642734527587891}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3354692459106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972527980804443}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972527980804443}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69521951675415}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}},{"name":"KZ.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69521951675415}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000689","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227226734161377}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.8855462074279785}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.850363254547119}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000690","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000691","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":11.111},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2408299999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000692","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.3","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}},{"name":"KR.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}}]}]}]}]},{"name":"NODE_0000693","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056233882904053}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056233882904053}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.607518196105957}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145547866821289}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145547866821289}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000695","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9964990615844727}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"designation_date":{"value":"2024-04-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9964990615844727}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.6","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69572114944458}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.8","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.729191780090332}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.2408299999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000696","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558164119720459}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"designation_date":{"value":"2024-08-24"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}},{"name":"LB.1.4.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558164119720459}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000697","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624444961547852}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.662596225738525}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624444961547852}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}},{"name":"LB.1.7.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}}]},{"name":"NODE_0000699","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111886501312256}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111886501312256}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438388347625732}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.472174167633057}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.925361394882202}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.925361394882202}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347464084625244}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415004730224609}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415004730224609}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.04741999999999978"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000704","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.689547538757324}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005441188812256}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"NODE_0000706","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.083190441131592}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.083190441131592}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.09660530090332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.7","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":50.174},"immune_escape":{"value":"1.817229820305529"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21767999999999987"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"LF.6","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.9","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.557812213897705}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.290716171264648}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.290716171264648}},"branch_attrs":{"mutations":{}}},{"name":"LF.4.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}}]},{"name":"NODE_0000708","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693272590637207}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C28660T"],"S":["T33A"]},"labels":{"aa":"S: T33A","spike_mutations":"T33A"}}},{"name":"LF.9.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"3-4 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5064377784729}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"designation_date":{"value":"2024-05-28"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"designation_date":{"value":"2024-06-29"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"designation_date":{"value":"2024-06-04"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000713","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000714","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}},{"name":"LF.8.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.106093406677246}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.106093406677246}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9550347328186035}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9550347328186035}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688606262207031}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688606262207031}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.221215724945068}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.829525470733643}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.829525470733643}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.795657634735107}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3794899999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":11.111},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3926199999999998"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.450676441192627}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.450676441192627}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.520935535430908}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992856025695801}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.721512317657471}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"NODE_0000724","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.106141090393066}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"NODE_0000726","node_attrs":{"div":61,"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.159374713897705}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.159374713897705}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7445478439331055}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000727","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"NODE_0000728","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G"],"ORF1a":["K1226E"]},"labels":{"aa":"ORF1a: K1226E"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"2-3 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}},{"name":"LZ.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"designation_date":{"value":"2024-08-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]},{"name":"internal_24bd909c","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.753526210784912}},"branch_attrs":{"mutations":{"nuc":["C22928T"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.14224"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.753526210784912}},"branch_attrs":{"mutations":{"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"internal_41eb7227","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"]},"labels":{"aa":"N: A152T; ORF1a: I740V"}},"children":[{"name":"LZ.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]}]}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858033657073975}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"1.03082"},"clade_membership":{"value":"24A"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858033657073975}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.04741999999999978"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.008905410766602}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.3277153968811035}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.3277153968811035}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000734","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206735610961914}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7741516492587035"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.27333999999999997"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"KP.4.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886737823486328}},"branch_attrs":{"mutations":{}}},{"name":"internal_7da46150","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000738","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679376125335693}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"designation_date":{"value":"2024-02-22"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679376125335693}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.20671999999999996"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.903770923614502}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064724922180176}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064724922180176}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000743","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"internal_bfd296bd","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785137176514}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.9018449783325195}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000745","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013365268707275}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013365268707275}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.616637229919434}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.12","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.10","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.455721378326416}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.14","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.764108657836914}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.096656322479248}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.764108657836914}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"internal_1e4c8e87","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.2861931324005127}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7908990401504723"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3312699999999998"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000750","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000751","node_attrs":{"div":64,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.9161720275878906}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.21942999999999988"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.532754421234131}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.17","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.18","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.5323338508605957}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.7","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206735610961914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.2.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.6","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3181399999999999"},"clade_membership":{"value":"24B"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.883235454559326}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}}]}]},{"name":"NODE_0000752","node_attrs":{"div":63,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987194061279297}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987194061279297}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":64,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519747734069824}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519747734069824}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5554650921238282"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15242"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"NODE_0000755","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125619888305664}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.1","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"designation_date":{"value":"2024-06-09"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.35004997253418}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":70,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":65,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.607268810272217}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.607268810272217}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000761","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000763","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"immune_escape":{"value":"1.7206397516519647"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.11924"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24C"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000765","node_attrs":{"div":67,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.12","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.857026100158691}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.10","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.15","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.14","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.4","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.8321967124938965}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.5","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.3","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.6","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.7","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5369762101413171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000767","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":69,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787517547607}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":68,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787517547607}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":72,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":"4-8 weeks"},"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-1.15353"},"clade_membership":{"value":"24E"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"21L"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.619511127471924}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000771","node_attrs":{"div":5,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.494636058807373}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.8"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.494636058807373}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":6,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325202703475952}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325202703475952}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.2"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000773","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.914329767227173}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.5","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.5"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.328583240509033}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.3","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.622591733932495}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.7","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.7"},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000774","node_attrs":{"div":10,"partiallyAliased":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.785727024078369}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.785727024078369}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.1"},"designation_date":{"value":"2022-09-05"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.2","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.4"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.3"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.71883"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"NODE_0000775","node_attrs":{"div":11,"partiallyAliased":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"DC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66094"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000776","node_attrs":{"div":7,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947989463806152}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1.1","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.1"},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1","node_attrs":{"div":7,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1"},"designation_date":{"value":"2022-05-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947989463806152}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.5"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.291128635406494}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.4"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.100764274597168}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.6"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.0240254402160645}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.9"},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.8"},"designation_date":{"value":"2022-07-29"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8587090969085693}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000777","node_attrs":{"div":8,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.2"},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000778","node_attrs":{"div":9,"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.11"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000779","node_attrs":{"div":11,"partiallyAliased":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5308081831240151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.67074"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10.1"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7561969850799493"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"CS.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5702799999999999"},"clade_membership":{"value":"22A"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000780","node_attrs":{"div":12,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1984522342681885}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":12,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5"},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1984522342681885}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.9"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39901000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2395055294036865}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"NODE_0000781","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.000426292419434}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"ORF1a":["M2096L"]},"labels":{"aa":"ORF1a: M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.8"},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3900210857391357}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000782","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.946847438812256}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5"},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.946847438812256}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.5.2","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.2"},"designation_date":{"value":"2022-08-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.243048667907715}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"NODE_0000783","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891695261001587}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.1"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5131304264068604}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.3"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.187767505645752}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0000784","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0763676166534424}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0763676166534424}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000785","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130263805389404}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.3"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.1"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.4","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.4"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5883099999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000786","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2"},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000787","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6570799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000788","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.391442775726318}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"designation_date":{"value":"2022-11-20"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77355"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000789","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2668371200561523}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"]}},"children":[{"name":"BA.5.1.11","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.11"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1"},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2668371200561523}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.16","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.16"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9540939331054688}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.12","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.12"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4273571968078613}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.14"},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.965997695922852}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.17","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.17"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.774637222290039}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.2"},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.26383900642395}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.24"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3640353679656982}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.28"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.258055686950684}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.30","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.30"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9021799564361572}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.3","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.3"},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1503868103027344}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.34","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.34"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.5"},"designation_date":{"value":"2022-07-20"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1470391750335693}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.4","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.4"},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.6","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.6"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.541717290878296}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.8","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.8"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6331067085266113}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"BA.5.1.7","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.7"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.886288642883301}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"NODE_0000790","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3361656665802}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3361656665802}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10.1"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0975565910339355}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0975565910339355}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15.1"},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000792","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213085651397705}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213085651397705}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000793","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"NODE_0000794","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33.1"},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_35cd","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.303285837173462}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.31"},"designation_date":{"value":"2022-11-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.38"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198990821838379}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198990821838379}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_bae4","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8467977046966553}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8467977046966553}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1158230304718018}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.1","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.1"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}},{"name":"DE.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.2"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}}]}]},{"name":"NODE_0000799","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.430185079574585}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.18"},"designation_date":{"value":"2022-08-28"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7965612411499023}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000800","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069729328155518}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069729328155518}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.1"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.2"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8074238300323486}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8074238300323486}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.113799095153809}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.113799095153809}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000803","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.255287170410156}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"designation_date":{"value":"2022-12-10"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"designation_date":{"value":"2022-12-23"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000804","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}},{"name":"DJ.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5218353271484375}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.27"},"designation_date":{"value":"2022-09-30"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29"},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000807","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"CL.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.56931734085083}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0000809","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.73331618309021}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.083285093307495}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.19"},"designation_date":{"value":"2022-09-04"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047452926635742}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.32"},"designation_date":{"value":"2023-01-15"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.9"},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.180713176727295}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000810","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.134702682495117}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.20"},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.535201072692871}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.37","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.37"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}},{"name":"BA.5.1.36","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.36"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}}]}]}]},{"name":"NODE_0000811","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.151430368423462}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.11"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.79317307472229}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10"},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000813","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000814","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}},{"name":"DF.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1"},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7135770320892334}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2"},"designation_date":{"value":"2022-05-25"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7135770320892334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000816","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.681718111038208}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.681718111038208}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.12"},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5279"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.980180025100708}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.17","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.17"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.486154556274414}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.19","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.19"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.18"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092384338378906}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.30"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.33"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6034899999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.4"},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5524494647979736}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.6"},"designation_date":{"value":"2022-07-14"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.914687395095825}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.8"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4910664558410645}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000817","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.093046188354492}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BF.14","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.14"},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.080418825149536}},"branch_attrs":{"mutations":{"nuc":["C16726T"],"ORF1b":["H1087Y"]},"labels":{"aa":"ORF1b: H1087Y"}}},{"name":"BF.35","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.35"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I"}}}]},{"name":"NODE_0000818","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278829097747803}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278829097747803}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006065368652344}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5959379308450252"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.33263"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.380862712860107}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006065368652344}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141825199127197}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141825199127197}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000821","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765230655670166}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11"},"designation_date":{"value":"2022-07-25"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765230655670166}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.462978363037109}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000822","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.166635990142822}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.292905807495117}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1811370849609375}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0000823","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7687714099884033}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.789764165878296}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.28"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2670040130615234}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.36","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.36"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8735761642456055}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.9"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4620237350463867}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000824","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318788051605225}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1"},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318788051605225}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000825","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1384167671203613}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"designation_date":{"value":"2022-12-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.563032084337257"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.3218"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.989957332611084}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1384167671203613}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000826","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1209096908569336}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.15"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.382328033447266}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.20"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.54063081741333}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000827","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.864675521850586}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.21"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1568257808685303}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.27"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3812053203582764}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000828","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.4587268829345703}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.13"},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.16"},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.369956970214844}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.22"},"designation_date":{"value":"2022-08-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.25"},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.29"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.740654468536377}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.34"},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685994625091553}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.23"},"designation_date":{"value":"2022-09-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74171257019043}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.324922561645508}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.324922561645508}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.48889999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278613567352295}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000831","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6619062423706055}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.24"},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000832","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160460948944092}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160460948944092}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000833","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7555084228515625}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.592723846435547}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000834","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2662811279296875}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000835","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.605587959289551}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8483927249908447}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000836","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":44,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"designation_date":{"value":"2023-02-08"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000837","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.604166269302368}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.42"},"designation_date":{"value":"2023-04-11"},"frameShifts":{"value":"ORF7b:14-44"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.397212505340576}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.26"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.32"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.259809494018555}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.37"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.417162895202637}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.40"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.287785291671753}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238624095916748}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238624095916748}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"designation_date":{"value":"2023-02-11"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0000840","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7"},"designation_date":{"value":"2022-07-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"designation_date":{"value":"2022-10-05"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.541252613067627}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.11","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.68569278717041}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5383851528167725}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.18","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.512576103210449}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.17","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6393200000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7448058128356934}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.21","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.22","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.24","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.23","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.26","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.8","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2593913078308105}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"BF.7.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7265231609344482}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"NODE_0000841","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.06282901763916}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}},{"name":"BF.7.16","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000842","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131449222564697}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}},{"name":"BF.7.19","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000843","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000844","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6759999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000845","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"designation_date":{"value":"2023-03-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.398621082305908}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000846","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762614250183105}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3122613430023193}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0000847","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000848","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.4","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"designation_date":{"value":"2023-01-25"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.5","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0000849","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.3","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.6","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000850","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6321210861206055}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.23"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8151862621307373}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.40","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.40"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.4"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.182602405548096}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.5","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.5"},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.824589729309082}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.9"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.992319345474243}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000851","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2575464248657227}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.10"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.743116855621338}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.628093719482422}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000852","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8561782836914062}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8561782836914062}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26.1"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.20828914642334}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]},{"name":"NODE_0000853","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190244674682617}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.22"},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.498509168624878}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.29","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.29"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.531074047088623}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.28","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.28"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.239920139312744}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.45","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.45"},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5131699999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998836994171143}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.52"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.161771774291992}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.55"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.999176263809204}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.59"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.273857116699219}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0000854","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9824576377868652}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9824576377868652}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39901000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.402865409851074}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0000855","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680343151092529}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680343151092529}},"branch_attrs":{"mutations":{}}},{"name":"DZ.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.2"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"DZ.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.57471227645874}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}}]}]},{"name":"NODE_0000856","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190244674682617}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.12"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3988966941833496}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.13"},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.693641424179077}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.14"},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.19"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7941062450408936}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.30"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.567555904388428}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.35","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.35"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.34","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.34"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.511683702468872}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.39","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.39"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.37"},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460197448730469}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.42","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.42"},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.43"},"designation_date":{"value":"2022-11-26"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5413273873731987"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5642800000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.44"},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.282501697540283}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.46"},"designation_date":{"value":"2022-12-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.53"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.239439964294434}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.54"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.244083404541016}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.58","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.58"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236837387084961}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.57"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7188966274261475}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.62"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.200337886810303}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.63"},"designation_date":{"value":"2023-02-14"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.61","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.61"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.7162909507751465}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.8","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.8"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9471049308776855}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.359752178192139}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.11"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.216500282287598}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.32"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36507511138916}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.812325954437256}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27"},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.812325954437256}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.800739765167236}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_1651","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.183877944946289}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.183877944946289}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7208595659836455"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4564899999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.672420024871826}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3631205558776855}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.30660604695253"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.56458"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3631205558776855}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6759999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.4745917320251465}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000861","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.41"},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.726137638092041}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.56"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.041235446929932}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329526901245117}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329526901245117}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47.1"},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000863","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4698426723480225}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4698426723480225}},"branch_attrs":{"mutations":{}}},{"name":"CN.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.2"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}},{"name":"CN.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.1"},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.227382183074951}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000864","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.1"},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.852180004119873}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.2"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.280703544616699}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"internal_6217","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.214096546173096}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.185972690582275}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.185972690582275}},"branch_attrs":{"mutations":{}}},{"name":"CD.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3253063676642168"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5594199999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}},{"name":"CD.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.35979999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.559537887573242}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}}]},{"name":"NODE_0000867","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064776420593262}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.50"},"designation_date":{"value":"2023-01-21"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74055290222168}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.51","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.51"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.903770923614502}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.60"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585160255432129}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000868","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.2"},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.36874999999999986"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.1"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.679447650909424}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0000869","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16"},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.1"},"designation_date":{"value":"2022-09-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.205173015594482}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.3"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}},{"name":"BU.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415644645690918}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25"},"designation_date":{"value":"2022-09-25"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415644645690918}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.1"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.356500625610352}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.3","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.3"},"designation_date":{"value":"2023-02-23"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.2"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.673305034637451}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"internal_93c4","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18"},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.033204555511475}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45785000000000003"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.993558883666992}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"internal_f379","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665871620178223}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665871620178223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000874","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3630194664001465}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.244806289672852}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40216999999999997"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921499729156494}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000875","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131978988647461}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48"},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131978988647461}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.4"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.705625534057617}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000876","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}},{"name":"DY.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000877","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.89189076423645}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.2"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.3"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2117154598236084}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6"},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2117154598236084}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.3"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.38661"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.831022262573242}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.2"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5295255377787571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6942999999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.206465244293213}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.6","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.6"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.885945796966553}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.4","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.4"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.632347583770752}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.5"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.982746124267578}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.7"},"designation_date":{"value":"2023-03-02"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"internal_7ebe","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}},{"name":"CP.8","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8"},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000880","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4362287521362305}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1"},"designation_date":{"value":"2022-10-13"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4362287521362305}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6003199999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}},{"name":"CP.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"designation_date":{"value":"2022-10-13"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.384659290313721}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"designation_date":{"value":"2022-11-02"},"frameShifts":{"value":"ORF8:117-122"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.319679260253906}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}}]}]},{"name":"NODE_0000881","node_attrs":{"div":20,"partiallyAliased":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071225166320801}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24"},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071225166320801}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.3"},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2413458824157715}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.667097091674805}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40293000000000007"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.667097091674805}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.376063346862793}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.376063346862793}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000884","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DG.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0000885","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.083762168884277}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.083762168884277}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0000886","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.002089500427246}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.71883"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.712406158447266}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0000887","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.607504844665527}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0000888","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.022320747375488}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"designation_date":{"value":"2022-12-29"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.022320747375488}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.657641887664795}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000889","node_attrs":{"div":13,"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.170691967010498}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"ORF1a":["Q556K"]},"labels":{"aa":"ORF1a: Q556K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":13,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3"},"designation_date":{"value":"2022-05-29"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.170691967010498}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.3"},"designation_date":{"value":"2022-06-24"},"frameShifts":{"value":"ORF7a:72-122"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782665967941284}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.5"},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.307540416717529}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000890","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8095927238464355}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.4","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.4"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2507734298706055}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}},{"name":"BA.5.3.2","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.2"},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9211783409118652}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}}]},{"name":"NODE_0000891","node_attrs":{"div":14,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{}}},{"name":"BE.2","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.2"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.800240993499756}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T"],"ORF1a":["T882I"]},"labels":{"aa":"ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.3"},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2200911045074463}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.5"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2715253829956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000892","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.511610984802246}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.10"},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.9"},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6685283184051514}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000893","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.290349960327148}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","T28693C"],"ORF1a":["M85-"]},"labels":{"aa":"ORF1a: M85-"}},"children":[{"name":"BE.7","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.7"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.395103931427002}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}},{"name":"BE.6","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.6"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5513799999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.737630844116211}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}}]},{"name":"NODE_0000894","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.721144437789917}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.11","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.11"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.008347511291504}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"BE.12","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.12"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"NODE_0000895","node_attrs":{"div":16,"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2481184005737305}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.13"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5088823627149919"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5231200000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.8"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":94},"qc.overallScore":{"value":56.25},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":1},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0000896","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245568752288818}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T"],"ORF1a":["T3308N"]},"labels":{"aa":"ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245568752288818}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000897","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2813496589660645}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60741"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000898","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530858993530273}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000899","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.40216999999999997"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9200546741485596}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000900","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5692699999999998"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000901","node_attrs":{"div":15,"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0249316692352295}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"ORF1b":["M1156I"]},"labels":{"aa":"ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1"},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0249316692352295}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.957712173461914}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000902","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295792102813721}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295792102813721}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000903","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5026299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8224959014481948"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49383999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000904","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.39120999999999995"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0000905","node_attrs":{"div":18,"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367693901062012}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6697299999999999"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"internal_874c","node_attrs":{"div":17,"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.770998001098633}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.770998001098633}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000907","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190595626831055}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5583100000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190595626831055}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.4997300000000001"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000908","node_attrs":{"div":19,"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.037123680114746}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"designation_date":{"value":"2022-08-24"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45952999999999994"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.037123680114746}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.5680790723509552"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BQ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.45205000000000006"},"clade_membership":{"value":"22B"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.677981376647949}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000909","node_attrs":{"div":21,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.380139112472534}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.380139112472534}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3855838775634766}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4368526935577393}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.57323"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7257362514460642"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6127800000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6570799999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8308113969466171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5446"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.457104206085205}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.424003601074219}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4287261962890625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.33"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9463791847229}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.914119720458984}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"designation_date":{"value":"2023-03-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.936223268508911}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4588372707366943}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.657702922821045}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000910","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761812686920166}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761812686920166}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"designation_date":{"value":"2023-01-26"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000911","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7374396324157715}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000912","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000913","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.866491794586182}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.866491794586182}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000914","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009603500366211}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.068519592285156}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176229476928711}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176229476928711}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000917","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710925579071045}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710925579071045}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"BQ.1.26.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}}]}]},{"name":"NODE_0000919","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4316978454589844}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0000921","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6853534127590314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6353800000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.400434494018555}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688451290130615}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688451290130615}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875689029693604}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"NODE_0000925","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9874397743924017"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66664"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000926","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"designation_date":{"value":"2023-04-28"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60833"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"designation_date":{"value":"2023-08-31"},"frameShifts":{"value":"ORF7a:83-122"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":31},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.0821590912755812"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6059300000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]},{"name":"internal_dbfb","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6925976779449897"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5174000000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7586450576782227}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.16","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.18","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.5464019775390625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4521586894989014}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.057005405426025}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.49690999999999996"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.637410640716553}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66401"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000931","node_attrs":{"div":23,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3929214477539062}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":23,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"designation_date":{"value":"2022-09-09"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3929214477539062}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.11"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8915650844573975}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.12"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.535731315612793}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.16"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"designation_date":{"value":"2022-11-03"},"frameShifts":{"value":"ORF8:122"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.21"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.17"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.149692535400391}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.19"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.225134372711182}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.20"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.24"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8728938682420008"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.26"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5921799999999998"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.841220855712891}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.25"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7449699999999998"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.07365083694458}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.30"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.60833"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.31"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.833066940307617}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.34"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.37"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.314393520355225}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.36"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.201074600219727}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.42"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.40"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.41"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9046709537506104}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.45"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.704440116882324}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.44"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.068450927734375}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.51"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9954097270965576}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.47"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.249934673309326}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.50"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.386298179626465}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.55"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.861405372619629}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.57"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.360784530639648}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.56"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530673503875732}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.58"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.3784332275390625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.6"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9752700328826904}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.63"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.371273994445801}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.60"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.64"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9168782234191895}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.66"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276081085205078}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.67"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.05605936050415}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.68"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.70"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.841140031814575}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.73"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.69"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.636171340942383}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.76"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.239450931549072}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"1.051732686328446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.75"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.77"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.9"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.731185436248779}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000932","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955434799194336}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955434799194336}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"designation_date":{"value":"2022-12-07"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.65602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.960555553436279}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7361","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2028326988220215}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2028326988220215}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.70602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.662565231323242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000934","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0995001792907715}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"designation_date":{"value":"2022-10-19"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0995001792907715}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"designation_date":{"value":"2023-01-12"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DU.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.108586311340332}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000935","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9425103664398193}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.23"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.781043529510498}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"designation_date":{"value":"2022-12-02"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.27"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.53029203414917}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000936","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500977039337158}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.29"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.79"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674434661865}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674434661865}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ET.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.596988677978516}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ES.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000939","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8486416339874268}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8486416339874268}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"designation_date":{"value":"2022-11-30"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DK.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.74371"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.994874000549316}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_bf35","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6950554847717285}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6950554847717285}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000941","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9105813557217661"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DP.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.66913"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452545166015625}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452545166015625}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FC.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9185686111450195}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000943","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9088191986083984}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9088191986083984}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.810015678405762}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{}}},{"name":"CZ.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.435018539428711}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"CZ.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6774299999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}}]},{"name":"NODE_0000945","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000946","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952062606811523}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952062606811523}},"branch_attrs":{"mutations":{}}},{"name":"ER.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"designation_date":{"value":"2023-03-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}}]}]},{"name":"NODE_0000947","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.2","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"DR.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"designation_date":{"value":"2023-01-03"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.548947334289551}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}}]},{"name":"NODE_0000948","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694454669952393}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694454669952393}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000949","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"EN.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}}]}]},{"name":"NODE_0000950","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.648621082305908}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.49","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.49"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.766948223114014}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.48","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.48"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.3889336585998535}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.78"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{}}},{"name":"EA.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.880706782961692"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.34834999999999994"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.922172546386719}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}},{"name":"EA.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478137016296387}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504777431488037}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504777431488037}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918827056884766}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.8300909996032715}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.188085079193115}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.897580623626709}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000954","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1676859855651855}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.54"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.59"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000955","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.43596076965332}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.43596076965332}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EH.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002801895141602}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002801895141602}},"branch_attrs":{"mutations":{}}},{"name":"DT.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.224767684936523}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}},{"name":"DT.1","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.7242"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.392630577087402}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.660925388336182}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.117684841156006}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.62"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302687644958496}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.61"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000959","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EZ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{}}},{"name":"EE.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131553649902344}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.1","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.184222221374512}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.5","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.522237300872803}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.840277671813965}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}}]},{"name":"NODE_0000961","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.25513219833374}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000962","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0000963","node_attrs":{"div":30,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"designation_date":{"value":"2023-04-17"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FQ.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000964","node_attrs":{"div":31,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"designation_date":{"value":"2023-03-03"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24659999999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468376159668}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EV.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.24659999999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]},{"name":"NODE_0000965","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"designation_date":{"value":"2023-01-24"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6288199999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135379791259766}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.745408535003662}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.65602"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"NODE_0000966","node_attrs":{"div":24,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1417622566223145}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1417622566223145}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.072010040283203}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":25,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1802849769592285}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1802849769592285}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000968","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138624668121338}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.3","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"EF.1.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"internal_e491","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000970","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656734943389893}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656734943389893}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EY.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000971","node_attrs":{"div":26,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024628162384033}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024628162384033}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.699550151824951}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000972","node_attrs":{"div":27,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-7.3331193923950195}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"DN.3","node_attrs":{"div":27,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000973","node_attrs":{"div":28,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000974","node_attrs":{"div":29,"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1.2","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8771384492554943"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.2"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.5626099999999999"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.1","node_attrs":{"div":34,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8990816968865659"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"2.05606"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1","node_attrs":{"div":29,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8744814686582322"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.4"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.6722600000000001"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.3"},"clade_who":{"value":"Omicron"},"ace2_binding":{"value":"0.77543"},"clade_membership":{"value":"22E"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLGRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGGGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGATGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTTTAATTGTTACTTTCCTTTACGATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/XBB/tree.json b/data/nextstrain/sars-cov-2/XBB/tree.json index 1309c4e9..df87820f 100644 --- a/data/nextstrain/sars-cov-2/XBB/tree.json +++ b/data/nextstrain/sars-cov-2/XBB/tree.json @@ -1 +1 @@ -{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/XBB/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/XBB/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/XBB/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/XBB/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/XBB/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/XBB/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/XBB/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/XBB/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{"nuc":["G1A","T44C","G405A","T9866C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A15451G","T15738C","C15939T","C16342T","C17859T","G19326A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21810T","A22000C","G22109C","A22200G","C22577G","C22599G","A22664C","C22895G","C22896T","A22898G","G22942T","C23019T","C23031T","A23040G","T25416C","G26275A","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["A11T"],"N":["E31-","R32-","S33-"],"ORF1a":["R47K","F3201L","S3675-","G3676-","F3677-"],"ORF1b":["S662G","P959S"],"ORF9b":["E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","A83V","Q146H","E183Q","E213G","H339D","T346R","I368L","P445V","S446G","K460N","S486F","S490F","Q493R"]},"labels":{"aa":"E: A11T; N: E31-, R32-, S33-; ORF1a: R47K, F3201L, S3675-, G3676-, F3677-; ORF1b: S662G, P959S; ORF9b: E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, A83V, Q146H, E183Q, E213G, H339D, T346R, I368L, P445V, S446G, K460N, S486F, S490F, Q493R","clade":"Omicron","spike_mutations":"L24-, P25-, P26-, A27S, A83V, Q146H, E183Q, E213G, H339D, T346R, I368L, P445V, S446G, K460N, S486F, S490F, Q493R"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.175270080566406}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAA","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAA"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAB","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAB"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.436409950256348}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAC","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAC"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAF"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAG","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAG"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAD","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAD"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.878465175628662}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAE","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAE"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAK","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAK"},"immune_escape":{"value":"0.3037714005953052"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAH","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAH"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.754757404327393}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAL","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAL"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAJ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAJ"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.642837047576904}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAM","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAM"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAP","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-07-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAP"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.004575729370117}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAN","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAN"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.080811023712158}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAR","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAR"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.452944755554199}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAQ","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAQ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAS","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAS"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.454671859741211}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAT","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAT"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.875851154327393}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAU","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAU"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.1733574867248535}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAV","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAV"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.717791557312012}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":82,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAW"},"immune_escape":{"value":"0.274687314409391"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E156-","F157-","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAZ","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAZ"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.731168270111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":4},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBA"},"immune_escape":{"value":"0.29808642936638835"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBD"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBE"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.574315547943115}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBH"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBG","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBG"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBN","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBN"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBM","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBM"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBP","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBP"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBR"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBS"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBT"},"immune_escape":{"value":"0.5037920175803539"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBQ"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBU","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBU"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBW"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBV"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBY","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBY"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCA"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XBZ","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBZ"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-04-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCB"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCD"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCC","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCC"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCE"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCG"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCJ"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCM","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCM"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCN"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCL","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCL"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCK","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCK"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCS","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCS"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCR","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCR"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCP","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCP"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCQ","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCQ"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCU","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCU"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCV"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCY","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCY"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCZ","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCZ"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XCW","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCW"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XDB","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDB"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XDC","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDC"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDE"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDF"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDH"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDG"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDJ","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDJ"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDL","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDL"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDM","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDM"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDN","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDN"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDS","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDS"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDT"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDU","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDU"},"immune_escape":{"value":"0.9475349114594978"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDW"},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XE","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":48},"designation_date":{"value":"2022-03-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XE"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEA","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEA"},"immune_escape":{"value":"1.2268340125514634"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDY","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDY"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDZ","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDZ"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEB","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEB"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XED"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":17.361},"partiallyAliased":{"value":"XED"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEE","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEE"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.853520393371582}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":950.694},"partiallyAliased":{"value":"XEG"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":9},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XG"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XEF","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":34.028},"partiallyAliased":{"value":"XEF"},"immune_escape":{"value":"1.7268345560655398"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XH","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XH"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XJ","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XJ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XK","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":45},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XK"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XM","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":46},"designation_date":{"value":"2022-03-31"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XM"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.152749061584473}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XL","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XL"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XP","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XP"},"immune_escape":{"value":"0.3616394203564539"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"placement_prior":{"value":-3.0006814002990723}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XN","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XN"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.342913627624512}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XQ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XQ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.5721659660339355}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XR","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XR"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XT","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XT"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.091723442077637}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XV","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XV"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.536415100097656}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XU","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XU"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XW","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-05-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XW"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XZ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XZ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.090399742126465}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XY"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBK.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBK.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBK"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCH.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCH.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCH"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCT.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCT"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDA.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDA.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDA"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEC.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":29.34},"partiallyAliased":{"value":"XEC.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":34.028},"partiallyAliased":{"value":"XEC"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"XDR.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}},{"name":"XDR.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.3.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.0838518142700195}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.0838518142700195}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49430513381958}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.2"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.1974196434021}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.1.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDQ.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.2"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.3"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.4"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":37,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.1.1"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.2","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"XDD.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.5"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XDK.4.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.4.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.4.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"NODE_0000032","node_attrs":{"div":61,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"internal_0d74e965","node_attrs":{"div":62,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.10"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.10"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.3"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.4"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.5"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.6"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.9","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.9"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.9"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.7"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.7.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.7.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.8"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.8.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.8.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":56,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.997220516204834}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.697917461395264}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":60,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":62,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"XAY.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000046","node_attrs":{"div":63,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":64,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":65,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.682618141174316}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"immune_escape":{"value":"0.752889267417711"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"placement_prior":{"value":-4.494446754455566}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"XDV.1.10"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.11"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.4","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.5"},"immune_escape":{"value":"1.5359962252743784"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.14808999999999992"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":6.25},"partiallyAliased":{"value":"XDV.1.2.1"},"immune_escape":{"value":"1.8051577060608006"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.26874999999999993"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}}]},{"name":"NODE_0000052","node_attrs":{"div":61,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.7"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"XDV.1.7.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000053","node_attrs":{"div":60,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.9.1"},"immune_escape":{"value":"1.5422010449483097"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20783000000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":68,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC"},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":68,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":58},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"XBC.2"},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.2.1"},"immune_escape":{"value":"0.44507236664312827"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000057","node_attrs":{"div":70,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":57},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"XBC.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":76,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.4"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":75,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.5"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000059","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.2.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":78,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":79,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}},{"name":"XBC.1.1.1","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1.1"},"immune_escape":{"value":"0.48837241784414276"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":76,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":76,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7.1"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7.2"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":79,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.1","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.3","node_attrs":{"div":81,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":83,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.4"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":84,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":84,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":87,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.4"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":88,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.5"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":85,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":88,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":87,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":89,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.6.1"},"immune_escape":{"value":"0.7550301657183831"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":87,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.6"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":86,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":86,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":89,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.1","node_attrs":{"div":92,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"immune_escape":{"value":"0.7420325830319254"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1.2","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1.3","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.207023620605469}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.390348434448242}},"branch_attrs":{"mutations":{"nuc":["C14178T","-29759G"]}}},{"name":"XBB.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.654644012451172}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.4"},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.3064099999999999"},"placement_prior":{"value":-4.654644012451172}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.4.1"},"immune_escape":{"value":"1.0810114368008295"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.26627999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000075","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.232290267944336}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.6.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C14178T","C14362T","C14574T","C22792A","C25539T"]}}},{"name":"XBB.8.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.479925632476807}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.479925632476807}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"NODE_0000080","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.121950149536133}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.121950149536133}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.148683547973633}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.256861209869385}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"NODE_0000081","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.453329563140869}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.453329563140869}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.11.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000082","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219453811645508}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.219453811645508}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.7.1"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65097"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.83268404006958}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"internal_d796","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.6","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"NODE_0000086","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":34,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.717053174972534}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-3.717053174972534}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.14"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.8983306884765625}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.20"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.18"},"immune_escape":{"value":"1.2567103717994188"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.0750199999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.22"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.21"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-12"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"placement_prior":{"value":-4.42367696762085}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.45538854598999}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.9"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.674048900604248}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"placement_prior":{"value":-4.709936141967773}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"placement_prior":{"value":-4.674048900604248}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"placement_prior":{"value":-4.8618388175964355}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.13"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.033972263336182}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"immune_escape":{"value":"1.0527558336884004"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84789"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.12"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.90647"},"placement_prior":{"value":-4.900045394897461}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.16"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.17"},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}},{"name":"JY.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"immune_escape":{"value":"0.9736186906064397"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89932"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.646721839904785}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.646721839904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.761235237121582}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000102","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"immune_escape":{"value":"1.0079043361863298"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.7709600000000001"},"placement_prior":{"value":-4.985507965087891}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.606808662414551}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.55094575881958}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.517807483673096}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.703529357910156}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.703529357910156}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.552662372589111}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.8","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_bb69915a","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.388531684875488}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}},{"name":"HH.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.4304351806640625}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.4304351806640625}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.898563385009766}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.898563385009766}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8265013694763184}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.568424701690674}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"immune_escape":{"value":"0.986824739722089"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.70075"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"GE.1.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000120","node_attrs":{"div":45,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":49,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":50,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.253464221954346}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.253464221954346}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.2032599449157715}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"GJ.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.6877522468566895}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-02"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.6877522468566895}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000130","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.5","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":47,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":48,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.052709102630615}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1.10","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.10"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13558"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.052709102630615}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.3","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.3"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.49564"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0545"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.49"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.89405"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.535830020904541}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.20"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.48"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.9722600000000003"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3403778076171875}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.3403778076171875}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":41,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"GW.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}}]},{"name":"NODE_0000141","node_attrs":{"div":46,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":48,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":48,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":54,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.3","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1255195140838623}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86729"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.27"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.2602599999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.29"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.36"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-5.3860321044921875}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.40"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.885027885437012}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.12"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.12.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.12.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.709931373596191}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-4.709931373596191}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.13.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.15"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.15.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000149","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.14.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.14.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_18e1f6df","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.220515251159668}},"branch_attrs":{"mutations":{"nuc":["G709T","T13704C"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.32.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.32","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.220515251159668}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.37.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.37.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.928167819976807}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.38"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.928167819976807}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.38.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.066565036773682}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.254011631011963}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.43"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.254011631011963}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.43.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.43.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344058036804199}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.44"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.344058036804199}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.44.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.44.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.038851737976074}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.45"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.038851737976074}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.45.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.45.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000156","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31.1"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31.2"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.7139763832092285}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.7139763832092285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-25"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.9892516136169434}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.34","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.569494247436523}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.05231"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000161","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.810415744781494}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.085368633270264}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"FW.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-4.810415744781494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000162","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.343214511871338}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.343214511871338}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962552070617676}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.962552070617676}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.714374542236328}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000167","node_attrs":{"div":38,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000168","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.7388600000000002"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69644832611084}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.69644832611084}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.357577323913574}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.357577323913574}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.77537202835083}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000173","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":40,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"NODE_0000175","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6362106800079346}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.079745769500732}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.30","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.30"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.744277477264404}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.069783687591553}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.46"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.47"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.47.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.47.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000177","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.1"},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.05408"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000178","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"NODE_0000179","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.73932409286499}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"placement_prior":{"value":-6.73932409286499}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.2"},"immune_escape":{"value":"1.1099290580037755"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6066099999999999"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000181","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000183","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000184","node_attrs":{"div":40,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"internal_b1afb4e5","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.43418"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"NODE_0000187","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000188","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.089523792266846}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000189","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.10.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}}]},{"name":"NODE_0000190","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000191","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.96117"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000193","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.2.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80721"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}}]}]},{"name":"NODE_0000194","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.90647"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000195","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000196","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000197","node_attrs":{"div":46,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7918386459350586}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7918386459350586}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.110"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.110"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.23376989364624}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.43"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.543598651885986}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.45"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.58"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.57"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.87"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.87"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93509"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873802423477173}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.062389373779297}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.873802423477173}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000200","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2794275283813477}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.101","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.101"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.101"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.10","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.10"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.755887031555176}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.104"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.104"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0973687171936035}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.109"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.109"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9660911560058594}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.653730630874634}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7371788024902344}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.007676124572754}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.29"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.41404999999999986"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.26","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4117631912231445}},"branch_attrs":{"mutations":{"nuc":["C920T"]}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.861788511276245}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.31"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8877837657928467}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.6405656337738037}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.063141822814941}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.282281398773193}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.36"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.254117965698242}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.40"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.95377"},"placement_prior":{"value":-4.218836784362793}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.51"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.948964834213257}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.52"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8478782176971436}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.54"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.59"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.107715606689453}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.63"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7518346309661865}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.62"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.189910888671875}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.64"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.1709489822387695}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.67"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7762694358825684}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.69"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.275579452514648}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.66"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.801894426345825}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.75"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.35540246963501}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.80"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.80"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.274980068206787}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.79"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.6546549797058105}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.82"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.82"},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.91194"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.85"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.85"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.914968967437744}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.98"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.98"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.99"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.99"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.521303653717041}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.97"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.97"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.439826965332031}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"NODE_0000201","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.362831115722656}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.174068450927734}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.362831115722656}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000202","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.663084030151367}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.396157264709473}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.663084030151367}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.7630462646484375}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.8095383644104}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.38"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.7630462646484375}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000204","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.283175945281982}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.7958831787109375}},"branch_attrs":{"mutations":{"nuc":["A11399G","T22930A"],"ORF1a":["M3712V"],"S":["F456L"]},"labels":{"aa":"ORF1a: M3712V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.86","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.283175945281982}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9230175018310547}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.943152904510498}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9230175018310547}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.136342525482178}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"immune_escape":{"value":"1.1023732112409157"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.29094"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.30"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.41123000000000004"},"placement_prior":{"value":-4.136342525482178}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738136291503906}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.92"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.738136291503906}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.4955267906188965}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.282939434051514}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.100"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4955267906188965}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7568650245666504}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-4.850849628448486}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.3"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-3.7568650245666504}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5239129066467285}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.971319675445557}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.107"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.5239129066467285}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.995249032974243}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-01-31"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.995249032974243}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000212","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.403249740600586}},"branch_attrs":{"mutations":{"nuc":["A22474C"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"XBB.1.5.105","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.105"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.105"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.108"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.108"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","C22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.400269508361816}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.50"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.71"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.48403999999999986"},"placement_prior":{"value":-4.380550861358643}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000214","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277669906616211}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"GC.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"immune_escape":{"value":"1.03073601411565"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9061"},"placement_prior":{"value":-4.990260124206543}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.277669906616211}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000215","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.036886692047119}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.036886692047119}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000216","node_attrs":{"div":41,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.7416800000000001"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.73864"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266819953918457}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.266819953918457}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"HP.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.286570072174072}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.286570072174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000220","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.9992594718933105}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.021956920623779}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.1186099999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.693673133850098}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.512119770050049}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.021956920623779}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000222","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000223","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000224","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000225","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}}]}]},{"name":"NODE_0000226","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000227","node_attrs":{"div":39,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000228","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576870918273926}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"immune_escape":{"value":"1.0346353162114479"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9873000000000001"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.174642086029053}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.576870918273926}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000229","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EK.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000230","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.037446975708008}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"HA.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.925134181976318}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"ORF1a":["G2868S","M3712V"]},"labels":{"aa":"ORF1a: G2868S, M3712V"}}},{"name":"NODE_0000231","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C920T","C21910A"]}},"children":[{"name":"EU.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":36,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}}]}]}]},{"name":"NODE_0000233","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.349449157714844}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.842705249786377}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.349449157714844}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000234","node_attrs":{"div":36,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000235","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.852022647857666}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.852022647857666}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425598621368408}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.425598621368408}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000239","node_attrs":{"div":42,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000241","node_attrs":{"div":42,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000242","node_attrs":{"div":44,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"immune_escape":{"value":"1.2868306565498102"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.20635"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000243","node_attrs":{"div":43,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376293182373}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"immune_escape":{"value":"1.3046787170970133"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.1261900000000002"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"NODE_0000244","node_attrs":{"div":41,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-22"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000245","node_attrs":{"div":43,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000249","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.4253100000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":44,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"internal_3ae12761","node_attrs":{"div":44,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000258","node_attrs":{"div":49,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000259","node_attrs":{"div":51,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":52,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"immune_escape":{"value":"1.3541583181563797"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.1446400000000003"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000261","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.413428544998169}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.106"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.106"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.20"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.676553726196289}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.188947677612305}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.27"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.5159149169921875}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.6741859912872314}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.098106384277344}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.56"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.201209545135498}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.60"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.6250386238098145}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.540223121643066}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.61"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.265577793121338}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.65"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.831235408782959}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.72"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.74"},"immune_escape":{"value":"1.0169257119491577"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9630099999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.76"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.102508068084717}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.78"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.81"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.81"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.628146171569824}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.449199199676514}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.83"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.83"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.5449676513671875}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.84"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.84"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.251712799072266}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.88"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.88"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.2988762855529785}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.89"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.89"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.153590202331543}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.90"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.90"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.91"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.91"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.224719524383545}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.94"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.94"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.448019504547119}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.96"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.96"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.11193323135376}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000262","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7867274284362793}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7867274284362793}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000263","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.83085"},"placement_prior":{"value":-4.0655517578125}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.42"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"immune_escape":{"value":"0.9838451476656441"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.83156"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.41"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185697078704834}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.135185718536377}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.48"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.185697078704834}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000266","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1880059242248535}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.218293190002441}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.103"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.1880059242248535}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9350799999999999"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000269","node_attrs":{"div":43,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8164870738983154}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.592982292175293}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.310765743255615}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8164870738983154}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000271","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000272","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]},{"name":"NODE_0000273","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"immune_escape":{"value":"1.0924169334128189"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.74638"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000278","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8006300926208496}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.89299"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8006300926208496}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}},{"name":"FD.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.37588357925415}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.37588357925415}},"branch_attrs":{"mutations":{}}},{"name":"FD.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}}]},{"name":"NODE_0000282","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.037048816680908}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.037048816680908}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.755037307739258}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.560482025146484}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.20585823059082}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.20585823059082}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000285","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000286","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"immune_escape":{"value":"0.950188045949472"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86018"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"immune_escape":{"value":"0.9788766097021935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.67693"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8926499999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"internal_77ad61e0","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}},{"name":"FY.5.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}}]},{"name":"NODE_0000303","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"NODE_0000304","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000305","node_attrs":{"div":39,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.996242046356201}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-2.996242046356201}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.11"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-3.181058645248413}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.12"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.10","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.10"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.275190353393555}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.14"},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.7388600000000002"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.16"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.17"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.18"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.089405059814453}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.19"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.20"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.22"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.21"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.23"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.24"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.25"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.26"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.1853718757629395}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.27"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.8"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.9"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000306","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.32"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000307","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"JM.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":40,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.29"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.30"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.31"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000310","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}}]}]},{"name":"NODE_0000311","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"internal_adf0d069","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121835708618164}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"JF.3","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"internal_398cc75a","node_attrs":{"div":47,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{}}},{"name":"JF.1.1.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.5","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"FU.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"2.14642"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}},{"name":"FU.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000318","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000319","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"NODE_0000320","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8164899999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.7","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.5","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000323","node_attrs":{"div":46,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}},{"name":"GY.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0856804847717285}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000325","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000326","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.941244125366211}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.210937023162842}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.210937023162842}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.6"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.13558"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000328","node_attrs":{"div":33,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.068836212158203}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"GD.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-4.331231594085693}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000329","node_attrs":{"div":34,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.389554500579834}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.063467979431152}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.233525276184082}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.18","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0403361320495605}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"FL.22","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.27","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.406124114990234}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.25","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.529069900512695}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.29","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.7904599999999999"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.216497898101807}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.7","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.6","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.937436103820801}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.164567947387695}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.9","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.411857604980469}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.389554500579834}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000330","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C6285T","G12907A","A27507C","C28770T"],"N":["T166I"],"ORF1a":["T2007I"]},"labels":{"aa":"N: T166I; ORF1a: T2007I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]},{"name":"NODE_0000331","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"immune_escape":{"value":"0.9957660361777405"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0848"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.30.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"NODE_0000336","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.33.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.515424728393555}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.33","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.35.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.917665481567383}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9744789600372314}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9744789600372314}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.5920999999999998"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"FL.10.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"immune_escape":{"value":"1.1216394663867173"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.98073"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000345","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000346","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.96117"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8835"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000347","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}},{"name":"FL.3.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.066182613372803}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}}]},{"name":"NODE_0000348","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282326698303223}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.282326698303223}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":35},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.671235084533691}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000353","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000354","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"internal_24b5ee08","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000356","node_attrs":{"div":41,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000357","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000358","node_attrs":{"div":48,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000359","node_attrs":{"div":49,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}},{"name":"KF.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}}]}]}]}]}]}]}]},{"name":"internal_7f0cfce5","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.670197010040283}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"FL.2.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_95ea4775","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.457831382751465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.93509"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"immune_escape":{"value":"1.0186868047371063"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.48144"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.3348299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000367","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"immune_escape":{"value":"0.9778643306477401"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.89211"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000372","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.06800999999999986"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000373","node_attrs":{"div":47,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{}}},{"name":"KC.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KC.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}}]}]},{"name":"NODE_0000374","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.36653995513916}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000375","node_attrs":{"div":46,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000376","node_attrs":{"div":47,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"immune_escape":{"value":"1.3005141566416802"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.0007299999999998658"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000377","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232717037200928}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000378","node_attrs":{"div":45,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000379","node_attrs":{"div":44,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000380","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.618598222732544}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.13","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.12","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.11","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.919648170471191}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.14","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.8","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"EG.7","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1186099999999999"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.618598222732544}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.20938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.397416591644287}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"placement_prior":{"value":-5.397416591644287}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000383","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000386","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.091670513153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.091670513153076}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.4","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317834377288818}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.317834377288818}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.169593811035156}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.346397876739502}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}},{"name":"EG.4.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.917497158050537}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3095011711120605}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000389","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541221857070923}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.541221857070923}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.088577747344971}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.5","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.569139003753662}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8091061115264893}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"EG.1.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.115445613861084}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}}]}]}]},{"name":"NODE_0000391","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173191070557}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000392","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"NODE_0000393","node_attrs":{"div":46,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000394","node_attrs":{"div":42,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.292908191680908}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.374487400054932}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.585853576660156}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000398","node_attrs":{"div":49,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-11-29"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"immune_escape":{"value":"1.4312755323086508"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.73257"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000399","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000400","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000402","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.3","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.8333635330200195}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9912302494049072}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.4253100000000001"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.4","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000403","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000404","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.10","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.025979999999999802"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.11","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"immune_escape":{"value":"1.3341105633249508"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.0887599999999999"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.4","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.3","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"immune_escape":{"value":"1.3005451981781486"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.21974"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.8","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.7","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043656826019287}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.048559999999999943"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"immune_escape":{"value":"1.3552393372267753"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.38161000000000006"},"placement_prior":{"value":-4.412596225738525}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000406","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000407","node_attrs":{"div":52,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000408","node_attrs":{"div":53,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000409","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"immune_escape":{"value":"1.1972306507819483"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.13706999999999997"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.19","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.21","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"immune_escape":{"value":"1.205901853206978"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.1481699999999999"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"immune_escape":{"value":"1.310148541751831"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.49366"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-11-27"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.31","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.25141716003418}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.30","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.32","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}},{"name":"HK.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"immune_escape":{"value":"1.2183176254438959"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.6088199999999999"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000416","node_attrs":{"div":51,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"immune_escape":{"value":"1.3534097328298118"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.48614000000000007"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000420","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.570084095001221}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.34.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"NODE_0000424","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2.1","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}},{"name":"HK.13.2","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.15","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.16","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"clade_membership":{"value":"23H"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_display":{"value":"23H (HK.3)"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.11","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.12","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.10","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.14","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.5","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.4","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.3","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.7","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.9","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.3123884201049805}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"clade_membership":{"value":"23H"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_display":{"value":"23H (HK.3)"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.15","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.15"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.830389499664307}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.16","node_attrs":{"div":1,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.16"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.232675552368164}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.19","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.19"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.5045647621154785}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.29116153717041}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":41},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.87.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.87.1"},"immune_escape":{"value":"0.6657453429914796"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.8217399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","C22000-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}},{"name":"BA.2.87","node_attrs":{"div":1,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.87"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.29116153717041}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.702070713043213}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":44},"designation_date":{"value":"2021-12-14"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.3"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.8285975456237793}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":46},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.807489812374115}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.9172141551971436}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":18},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.1.7"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.1350864171981812}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000434","node_attrs":{"div":63,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8541454076766968}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8541454076766968}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000435","node_attrs":{"div":66,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066986083984375}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066986083984375}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":83,"totalAminoacidDeletions":{"value":2},"totalAminoacidSubstitutions":{"value":19},"designation_date":{"value":"2021-04-21"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.617.2"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.5602865815162659}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E156-","F157-","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"A","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"A"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"A"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.94581937789917}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}},{"name":"B","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":0},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"internal_c0ce","node_attrs":{"div":1,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4849481582641602}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.9632513523101807}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.11"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"placement_prior":{"value":-4.008795738220215}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.18"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.06190824508667}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.20"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.934055805206299}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.24"},"immune_escape":{"value":"0.01261797446067892"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.03172000000000008"},"placement_prior":{"value":-3.048215866088867}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.28","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.28"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.9567365646362305}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.26","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.26"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.5785768032073975}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.27","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.27"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9515457153320312}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.29","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.29"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2466073036193848}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.30","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.30"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.192726135253906}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.32"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7269387245178223}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.39","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-05-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.39"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.341081619262695}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.4","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.4"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7649905681610107}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.42","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.42"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.41","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.41"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.732407331466675}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.46"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.784368991851807}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.43","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.43"},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"placement_prior":{"value":-4.411663055419922}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.5","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.5907039642333984}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.48","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.48"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7901194095611572}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.50"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.213821887969971}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.55"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.216464519500732}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.54","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.54"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.137808799743652}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.58"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.060901165008545}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.59","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.59"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.600815296173096}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.61","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.61"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.497117042541504}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.62"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.002071380615234}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.60","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.60"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.64","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.64"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.522981643676758}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.63","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.63"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.172652721405029}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.65","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.65"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.866844415664673}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.70","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.70"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.473325729370117}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.77"},"immune_escape":{"value":"0.3221048136122174"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9213199999999999"},"placement_prior":{"value":-5.606687545776367}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.8"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.326139450073242}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.82","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.82"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.82"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-5.217201232910156}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.83"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.83"},"immune_escape":{"value":"0.22071783986880583"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.12534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.85"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.85"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.306359767913818}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000438","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565203905105591}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.565203905105591}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.2.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000439","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1365203857421875}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.23"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1365203857421875}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.23.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.825143814086914}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.31.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.869024753570557}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.31","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.31"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.825143814086914}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000441","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8949601650238037}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.33"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.087352275848389}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}},{"name":"BA.2.35","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-29"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.35"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"placement_prior":{"value":-4.571066856384277}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020925521850586}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.40.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.40.1"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.7483084201812744}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.40","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.40"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8020925521850586}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000443","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.982405185699463}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.56.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.56.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.698922157287598}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}},{"name":"BA.2.56","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.56"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-2.982405185699463}},"branch_attrs":{"mutations":{}}}]},{"name":"BA.2.10_internal","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.6351211071014404}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.6351211071014404}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.685215473175049}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.082213878631592}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.4"},"immune_escape":{"value":"0.3166622371297313"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.73328"},"placement_prior":{"value":-5.095425605773926}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4718618392944336}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.4718618392944336}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.1.1"},"immune_escape":{"value":"0.6181860283242497"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.09519000000000005"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000446","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.908740520477295}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.14"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.693842649459839}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.22"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2798104286193848}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.34"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.117501735687256}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.36"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.0866947174072266}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.47","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.47"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.130222797393799}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.49"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8066627979278564}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.51","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.51"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7612979412078857}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.52"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8890013694763184}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.6","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.6"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.6700806617736816}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.69"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.045757293701172}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.7","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.384455680847168}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.72","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.72"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7303617000579834}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.71","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.71"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.731685161590576}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.81","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.81"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.81"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.353763580322266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.80","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.80"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.80"},"immune_escape":{"value":"0.31190394480802347"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10838000000000005"},"placement_prior":{"value":-5.6476006507873535}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.25"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.25.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.996367454528809}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"NODE_0000448","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.908740520477295}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.45","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-23"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.45"},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.30756000000000006"},"placement_prior":{"value":-3.734736680984497}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.53","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.53"},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.33552999999999994"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.7460718154907227}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.44"},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"placement_prior":{"value":-4.219630718231201}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5670673847198486}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.13"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-3.5670673847198486}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.13.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.0240631103515625}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1937501430511475}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.1937501430511475}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.3531692028045654}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.4"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.628756284713745}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2406184673309326}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.6"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.506667613983154}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.828467607498169}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000452","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.4851491451263428}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.10","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.10"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.09907865524292}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1285204887390137}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.4851491451263428}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.11"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7979793548583984}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.14"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.958454132080078}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.13"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.348191499710083}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.12"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.15"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8729355335235596}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.17"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8992807865142822}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.18"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.462960243225098}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.19"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-4.702410697937012}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.4"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.302166938781738}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8020241260528564}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.9"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8521687984466553}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.8"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"internal_305a","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.16"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.16.1"},"immune_escape":{"value":"0.43687237373984505"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9456899999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601692199707031}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.21"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06758"},"placement_prior":{"value":-4.830438613891602}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.21.1"},"immune_escape":{"value":"0.4733677107846063"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9683399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000455","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17173957824707}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.6","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.6"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.009570121765137}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}},{"name":"BA.2.3.22","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.22"},"immune_escape":{"value":"0.42289430257523936"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.37526000000000004"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}}]},{"name":"internal_019b","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9328737258911133}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9328737258911133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000457","node_attrs":{"div":29,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"immune_escape":{"value":"0.6029918987948071"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.6589000000000002"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-09-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1"},"immune_escape":{"value":"0.49181526572268314"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.66194"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"immune_escape":{"value":"0.4975483601650658"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.66821"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000458","node_attrs":{"div":26,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.10"},"immune_escape":{"value":"0.7593324873420084"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.8190299999999999"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000459","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.4"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"immune_escape":{"value":"0.7016283989012374"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.91683"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.6"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"immune_escape":{"value":"0.8143059671640498"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9440299999999998"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8"},"immune_escape":{"value":"0.7255583352017505"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.99403"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000463","node_attrs":{"div":30,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000464","node_attrs":{"div":31,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000465","node_attrs":{"div":35,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"immune_escape":{"value":"1.0761544902802131"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.28625999999999996"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.11","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.11"},"immune_escape":{"value":"1.0179803928276123"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.35566999999999993"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.12","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.12"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.3","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.3"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.9"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.2"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000468","node_attrs":{"div":29,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000469","node_attrs":{"div":30,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"immune_escape":{"value":"0.9785485534494837"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9729599999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1254796981811523}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.17"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.11018180847168}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.21"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.37"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.095773220062256}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.57"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.153290271759033}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.66"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.675938129425049}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.68"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.929081678390503}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.73"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.0335774421691895}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-23"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.74"},"immune_escape":{"value":"0.33134042675697756"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.21698000000000003"},"placement_prior":{"value":-3.8886899948120117}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.78"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.664786338806152}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000471","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0964372158050537}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.67"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000472","node_attrs":{"div":6,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.79"},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.79.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.79.1"},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000473","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.63395619392395}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-3.63395619392395}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000474","node_attrs":{"div":6,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76.1"},"immune_escape":{"value":"0.2640232066165751"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.18492"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}},{"name":"BA.2.76.2","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76.2"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4425623416900635}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.4425623416900635}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.741132736206055}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.3"},"immune_escape":{"value":"0.07383293656037815"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.08445999999999997"},"placement_prior":{"value":-4.741132736206055}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.3.1"},"immune_escape":{"value":"0.370455061085298"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.11188000000000006"},"placement_prior":{"value":-4.580904006958008}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000477","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.986060619354248}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.1"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.085832118988037}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000478","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.909948348999023}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.2"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.4"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.449790954589844}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7789523601531982}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7789523601531982}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.2"},"immune_escape":{"value":"0.062348652344665065"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07350000000000005"},"placement_prior":{"value":-3.9584996700286865}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"clade_membership":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0569682121276855}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.0569682121276855}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000481","node_attrs":{"div":7,"clade_membership":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292356729507446}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.2","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-06-18"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.2"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.0345394611358643}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.3","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.3"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.5","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-28"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.5"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.4","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.4"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.6","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-01"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.6"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}},{"name":"BG.7","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.7"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":18,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8684661388397217}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-3.8684661388397217}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.10"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.499698162078857}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.7"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-4.55503511428833}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.8"},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04854"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.7365007400512695}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.9"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.7365007400512695}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.9.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"placement_prior":{"value":-4.5146331787109375}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4"},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.13451"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000485","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.2"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"placement_prior":{"value":-3.378986120223999}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.3"},"immune_escape":{"value":"0.5588825437629772"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.24593"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000487","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"immune_escape":{"value":"0.7451886007636047"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.12575999999999996"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000488","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.4"},"immune_escape":{"value":"0.5013910005227346"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.10514"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000489","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}},{"name":"BR.5","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.5"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.099649429321289}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.099649429321289}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.4"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000491","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210728168487549}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.5"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.16854"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000492","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.586776256561279}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.586776256561279}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.043233394622803}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000493","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.19193"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.3464399999999999"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"immune_escape":{"value":"0.6011952983295785"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.56756"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.6"},"immune_escape":{"value":"0.5544855553668998"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.11979"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.636732578277588}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.636732578277588}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.278948783874512}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.278948783874512}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.083024501800537}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}},{"name":"BY.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-5.083024501800537}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_147e","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{}}},{"name":"CA.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.2"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"placement_prior":{"value":-4.7165374755859375}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.4","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.4"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.5"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.7"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.6"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.2371799999999999"},"placement_prior":{"value":-4.580175399780273}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096994400024414}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.096994400024414}},"branch_attrs":{"mutations":{}}},{"name":"BN.5","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.5"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.532908916473389}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"BN.6","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.6"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.629100322723389}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.4","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.4"},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"placement_prior":{"value":-4.784391403198242}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"internal_40f9","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215889930725098}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}},{"name":"BN.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.2"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-5.215889930725098}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.3"},"immune_escape":{"value":"0.5060716304521155"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.11385"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"immune_escape":{"value":"0.653690335850791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08339"},"placement_prior":{"value":-3.9134323596954346}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}}]},{"name":"NODE_0000503","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.74121356010437}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.74121356010437}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.221138954162598}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.97773551940918}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.7","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"immune_escape":{"value":"0.9193315170816834"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.5340599999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000504","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"BN.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000505","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"immune_escape":{"value":"0.7470314258752732"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1331"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"immune_escape":{"value":"0.7815531080803261"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.31233"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000507","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000508","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.136174201965332}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.220160484313965}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000510","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"immune_escape":{"value":"0.7326886306518271"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.21326"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000511","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000512","node_attrs":{"div":31,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"FR.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"NODE_0000513","node_attrs":{"div":35,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49798059463501}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-5.060053825378418}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"immune_escape":{"value":"1.0513083167390975"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.16291"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.12","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.856032848358154}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.576071739196777}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.3","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}},{"name":"EJ.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.13","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-06"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.11","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.791740894317627}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000520","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.306234359741211}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.306234359741211}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-5.302023887634277}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.5","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.5"},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"placement_prior":{"value":-5.031914234161377}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.6"},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"internal_42af","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.044631481170654}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.044631481170654}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"immune_escape":{"value":"0.5272935807019111"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.26994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.549932479858398}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.78817"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-08-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000525","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458258628845215}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}},{"name":"BM.1.1.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}}]},{"name":"internal_f6c6","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.43724"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000528","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"immune_escape":{"value":"0.9457248359372292"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.87567"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.26216459274292}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000529","node_attrs":{"div":28,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000530","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000531","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-06"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}},{"name":"CV.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000532","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000533","node_attrs":{"div":29,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000534","node_attrs":{"div":35,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000535","node_attrs":{"div":39,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000539","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852804660797119}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.0219999999999998"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"immune_escape":{"value":"0.7685109779549473"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.36891999999999997"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000542","node_attrs":{"div":25,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000543","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":69},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"CH.1.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"immune_escape":{"value":"0.9441222497200389"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:59-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.08511000000000003"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000544","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000545","node_attrs":{"div":31,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000546","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000547","node_attrs":{"div":29,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000548","node_attrs":{"div":31,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"DV.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000555","node_attrs":{"div":40,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000556","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}},{"name":"JV.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}}]}]},{"name":"NODE_0000559","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000560","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000561","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000562","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000563","node_attrs":{"div":27,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}},{"name":"GP.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0000564","node_attrs":{"div":27,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462465286255}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000565","node_attrs":{"div":30,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000566","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000567","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000568","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":34},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":34},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000570","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-31"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000572","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000574","node_attrs":{"div":37,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-04-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"immune_escape":{"value":"0.9815994835819151"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.16085999999999998"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000577","node_attrs":{"div":43,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000578","node_attrs":{"div":50,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.659756660461426}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-08-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.659756660461426}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.4"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.5"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000579","node_attrs":{"div":52,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}},{"name":"LV.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}}]},{"name":"NODE_0000580","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-06-13"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.7"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000581","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.7.1"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"immune_escape":{"value":"1.6738025507980547"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.12555999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000582","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000583","node_attrs":{"div":56,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-03-05"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2"},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.15919"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000584","node_attrs":{"div":60,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-03-20"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000585","node_attrs":{"div":52,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.786079406738281}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.4"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.519155979156494}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000586","node_attrs":{"div":53,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.825652837753296}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-3.825652837753296}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.12"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.16","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.16"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.14","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.14"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.15","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.15"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.17","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.17"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.18","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.18"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.19","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.19"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.6"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.7"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.8","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.8"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.9","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.9"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"NODE_0000587","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.11"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000588","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.13"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000589","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.5"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.6465599999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000590","node_attrs":{"div":55,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000591","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"ORF1a":["P892S"]},"labels":{"aa":"N: H300Y; ORF1a: P892S"}},"children":[{"name":"JN.3.2.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.3.2","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000592","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000593","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000594","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.369668006896973}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.10"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.502495765686035}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000595","node_attrs":{"div":58,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.788806915283203}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-09-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-2.788806915283203}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.12","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.26806999999999986"},"placement_prior":{"value":-5.217971324920654}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.10","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.4131927490234375}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.17","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9045615196228027}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.063985347747803}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.875726699829102}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.6741979122161865}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.28","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.40299129486084}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}}},{"name":"JN.1.3","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.494213581085205}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.493702411651611}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.403775691986084}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.0336198806762695}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.297048091888428}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.232478618621826}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.8044490814208984}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.11747407913208}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.342803478240967}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.61","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"immune_escape":{"value":"1.496607246855186"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.93036"},"placement_prior":{"value":-4.427524089813232}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.66","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"JN.1.67","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.554509162902832}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.108648300170898}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.108648300170898}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.2.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.971957206726074}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240912437438965}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-02-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"placement_prior":{"value":-5.240912437438965}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013584613800049}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.322965145111084}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.013584613800049}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.161866188049316}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.161866188049316}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.261717796325684}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844590663909912}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.844590663909912}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.38.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.392269611358643}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.392269611358643}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.43.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741122722625732}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.741122722625732}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.44.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.84599494934082}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5013346672058105}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.54.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"immune_escape":{"value":"1.532734695870142"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.05681999999999991"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}},{"name":"JN.1.54","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.5013346672058105}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906701564788818}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.56.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"immune_escape":{"value":"1.5395016697354735"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.7602899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.906701564788818}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803345680236816}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.803345680236816}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.59.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":8.507},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235188961029053}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.235188961029053}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.493972301483154}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000607","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.167296886444092}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.167296886444092}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.63.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.744463920593262}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.04854154586792}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.04854154586792}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250698566436768}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.250698566436768}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.39476203918457}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.39476203918457}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4552364349365234}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332151889801025}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.332151889801025}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.36.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.063086032867432}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005958557128906}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.005958557128906}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.993703842163086}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.40569543838501}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.40569543838501}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082462787628174}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.082462787628174}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.513469696044922}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.513469696044922}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.825034141540527}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"internal_b7e309e8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.62","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","G23604A"],"S":["V62F","R681H"]},"labels":{"aa":"S: V62F, R681H","spike_mutations":"V62F, R681H"}}},{"name":"NODE_0000620","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{"nuc":["G4162A","G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9000465869903564}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9000465869903564}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.853470325469971}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.175985336303711}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.564305782318115}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655609130859375}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9655609130859375}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.303173065185547}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-18"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ME.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.27215999999999985"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894876480102539}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.894876480102539}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.83441162109375}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.83441162109375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000629","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2595099999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}},{"name":"LN.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{}}},{"name":"MF.2","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}},{"name":"MF.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000632","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24034T","C24370T","A29700G"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000633","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"immune_escape":{"value":"1.3745641202332524"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.9318500000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000634","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000635","node_attrs":{"div":68,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343790531158447}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.343790531158447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000637","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548246383666992}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.548246383666992}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.693402290344238}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.1249308586120605}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566922187805176}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"NODE_0000642","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000644","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000645","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4388251304626465}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000646","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250442504883}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.617250442504883}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.769711017608643}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.769711017608643}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753198623657227}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"NODE_0000650","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-08-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":96},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}},{"name":"LU.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.396686553955078}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772514820098877}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.772514820098877}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.49.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.318779945373535}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.515067100524902}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000655","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":68,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.30217999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000657","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309075355529785}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.409302234649658}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.309075355529785}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.224586486816406}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872847080230713}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.872847080230713}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.486630439758301}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.534714698791504}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.534714698791504}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.343343257904053}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.343343257904053}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917464256286621}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.917464256286621}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2406325340271}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.9638495445251465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000664","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"placement_prior":{"value":-5.469202041625977}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.105811595916748}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.098007678985596}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.57.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.08313"},"placement_prior":{"value":-4.566637992858887}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.69068717956543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.287435054779053}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.175660133361816}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000671","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000672","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.04395"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.95433"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7120614051818848}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.7120614051818848}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.776768207550049}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.74375057220459}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.159214973449707}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000677","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.8164632320404053}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.098134517669678}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.037208080291748}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{}}},{"name":"KV.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}},{"name":"KV.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782661437988281}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.782661437988281}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000681","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769671440124512}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.769671440124512}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.145885944366455}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000682","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.528179883956909}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.528179883956909}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000684","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642605304718018}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.642605304718018}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.3354692459106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.97365140914917}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.97365140914917}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000689","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227312564849854}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.8855814933776855}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.850395679473877}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000690","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.5","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"KR.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000691","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":11.111},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000692","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.3","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"NODE_0000693","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0563764572143555}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.0563764572143555}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.607524394989014}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1424689292907715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.1424689292907715}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.6","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.8","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000696","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-24"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000697","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.662585735321045}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000699","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883163452148}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.111883163452148}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.472174167633057}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000701","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.347520351409912}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000702","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.716819763183594}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.0124382972717285}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_dc847259","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415851593017578}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.415851593017578}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.685051441192627}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.04741999999999978"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000706","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.079800128936768}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.079800128936768}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":50.174},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"immune_escape":{"value":"1.817229820305529"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21767999999999987"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-7.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000712","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671465873718262}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.671465873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000713","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000714","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000715","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}},{"name":"LF.8.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.091001987457275}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.091001987457275}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958034038543701}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.958034038543701}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","K182-","Q183-","G184-","N185-","F186-","N188Q","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, K182-, Q183-, G184-, N185-, F186-, N188Q, L189A","spike_mutations":"Y28H, K182-, Q183-, G184-, N185-, F186-, N188Q, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688790798187256}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.688790798187256}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.81335973739624}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-4.81335973739624}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-4.7956719398498535}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":11.111},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3926199999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994C","C21998-","A21999-","C22000-","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451901912689209}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.451901912689209}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.520982265472412}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}},{"name":"LQ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000725","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.054087162017822}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172401428222656}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.172401428222656}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"NODE_0000728","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}},{"name":"LZ.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000730","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}},{"name":"LZ.2.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.329638481140137}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.329638481140137}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.512091159820557}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.04741999999999978"},"placement_prior":{"value":-6.009568691253662}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000734","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.230648040771484}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.4.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"immune_escape":{"value":"1.7741516492587035"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.27333999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}},{"name":"KP.4.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]}]}]},{"name":"NODE_0000738","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.700614929199219}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-02-22"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.700614929199219}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.919792890548706}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.919792890548706}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.4","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"LP.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"NODE_0000743","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928211212158}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.200928211212158}},"branch_attrs":{"mutations":{}}},{"name":"internal_bfd296bd","node_attrs":{"div":67,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000745","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.814105272293091}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.814105272293091}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.616664409637451}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.439517021179199}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.12","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.083328723907471}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.0966644287109375}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"internal_1e4c8e87","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.2861931324005127}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"immune_escape":{"value":"1.7908990401504723"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"-0.40119000000000016"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000750","node_attrs":{"div":67,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":96},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000751","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.9114367961883545}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.21942999999999988"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.532774448394775}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.196527481079102}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.17","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.6","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.883235454559326}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.7","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000752","node_attrs":{"div":63,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9876158237457275}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9876158237457275}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.6","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.772136211395264}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.3.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094733715057373}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.094733715057373}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"immune_escape":{"value":"1.5554650921238282"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15242"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"NODE_0000755","node_attrs":{"div":68,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ML.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"ML.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ML.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9918503761291504}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9918503761291504}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.093895435333252}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-09"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.350859642028809}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":70,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000761","node_attrs":{"div":68,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000763","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"immune_escape":{"value":"1.7206397516519647"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.11924"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}},{"name":"MK.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000765","node_attrs":{"div":67,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.857026100158691}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.15","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.3","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.4","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.8321967124938965}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.6","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.7","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"immune_escape":{"value":"1.5369762101413171"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.3172000000000001"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"MC.11","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000767","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.637859344482422}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000771","node_attrs":{"div":5,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.49234676361084}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.49234676361084}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":6,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325173854827881}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.325173854827881}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000773","node_attrs":{"div":7,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.9142110347747803}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.3","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.5","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000774","node_attrs":{"div":10,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.2","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.2"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-05"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.71883"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000775","node_attrs":{"div":11,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.5.1"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.66094"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000776","node_attrs":{"div":7,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947638988494873}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.6947638988494873}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0240254402160645}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.100764274597168}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.872378349304199}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000777","node_attrs":{"div":8,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000778","node_attrs":{"div":9,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.11"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000779","node_attrs":{"div":11,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.10"},"immune_escape":{"value":"0.5308081831240151"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.67074"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.10.1"},"immune_escape":{"value":"0.7561969850799493"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5702799999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000780","node_attrs":{"div":13,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155839443206787}},"branch_attrs":{"mutations":{"nuc":["C1931A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF1a":["Q556K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF1a: Q556K; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.9592297077178955}},"branch_attrs":{"mutations":{"nuc":["A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}}},{"name":"BA.5.3","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.155839443206787}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":36},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:72-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7818877696990967}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.1","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.121390342712402}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":36},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"placement_prior":{"value":-3.2392046451568604}},"branch_attrs":{"mutations":{"nuc":["T1570C","A1931C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["K556Q","T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: K556Q, T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"BE.2","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.800013303756714}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T","G28681T"],"N":["E136D"],"ORF1a":["T882I"]},"labels":{"aa":"N: E136D; ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2200896739959717}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","G28681T","C28724T"],"N":["E136D","P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: E136D, P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.121390342712402}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"NODE_0000781","node_attrs":{"div":14,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.80837082862854}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.920682191848755}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.250558853149414}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}}]},{"name":"NODE_0000782","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9044742584228516}},"branch_attrs":{"mutations":{"nuc":["A1931C","A6551C","G29032A"],"ORF1a":["K556Q","M2096L"]},"labels":{"aa":"ORF1a: K556Q, M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3900210857391357}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000783","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.437628269195557}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A","G28681T"],"N":["E136D"],"S":["K444T","N460K"]},"labels":{"aa":"N: E136D; S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.10"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.9"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.6684834957122803}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000784","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2901611328125}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","G28681T","T28693C"],"N":["E136D"],"ORF1a":["M85-"]},"labels":{"aa":"N: E136D; ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.7371015548706055}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":95},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.394863128662109}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000785","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9449503421783447}},"branch_attrs":{"mutations":{"nuc":["A1931C","C21789T"],"ORF1a":["K556Q"],"S":["T76I"]},"labels":{"aa":"ORF1a: K556Q; S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.243032455444336}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"BA.5.5","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.9449503421783447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000786","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891446352005005}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}},{"name":"BA.5.5.1","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-3.5124127864837646}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}}]}]},{"name":"NODE_0000787","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.720151662826538}},"branch_attrs":{"mutations":{"nuc":["G28681T","T28693C"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BE.11","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.007559776306152}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"BE.12","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"NODE_0000788","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.232304573059082}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":95},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.13"},"immune_escape":{"value":"0.5088823627149919"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5231200000000001"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":94},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"BA.5.3.1.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":1},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T","G28681T"],"N":["E136D"],"ORF1a":["T3308N"]},"labels":{"aa":"N: E136D; ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000790","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2813496589660645}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000791","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"placement_prior":{"value":-3.919694185256958}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000793","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"CQ.1.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]}]}]}]}]},{"name":"NODE_0000794","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075937032699585}},"branch_attrs":{"mutations":{"nuc":["A1931C","T4906C","C17402T","T18957C","C21077T"],"ORF1a":["K556Q"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1a: K556Q; ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.075937032699585}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000795","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130266189575195}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5883099999999998"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000796","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3249030113220215}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.3249030113220215}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000797","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6570799999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000798","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.391442775726318}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}}]}]}]}]},{"name":"NODE_0000799","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2639026641845703}},"branch_attrs":{"mutations":{"nuc":["A1T","A1931C","T27438C","C29666T"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.2639026641845703}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.12"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.4234297275543213}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.14","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.14"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.9656171798706055}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.16"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9540679454803467}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.17"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.774606227874756}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2636609077453613}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.24"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3640329837799072}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.28"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.247698783874512}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.1495773792266846}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.30"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.902099132537842}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.34"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0658464431762695}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A21999-","C22000-","A22001-","A22002-","A22003-","A22004-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["H146-","K147-","N148H","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: H146-, K147-, N148H, P1162S","spike_mutations":"H146-, K147-, N148H, P1162S"}}},{"name":"BA.5.1.6","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.541465997695923}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.4","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.7","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8861465454101562}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.5","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.146693468093872}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.8","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.632486343383789}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0000800","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.10.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9345104694366455}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.15"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.15.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-3.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000802","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2127861976623535}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2127861976623535}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.22.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","T21994C","T21995-","A21996-","C21997-","C21998-","A21999-","C22000-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000803","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.26"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.26.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3030779361724854}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.38"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198533058166504}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.35"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.198533058166504}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.35.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000806","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415742874145508}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.33"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.415742874145508}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.33.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8465638160705566}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8465638160705566}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.115744113922119}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.33618688583374}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0000809","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.429936408996582}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.18"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000810","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069718837738037}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.069718837738037}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_b005","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.521807909011841}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.27"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0000814","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}},{"name":"CL.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]}]}]}]},{"name":"internal_2d50","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806924343109131}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.806924343109131}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.112699508666992}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-5.112699508666992}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000817","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.253764629364014}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-12-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000818","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"NODE_0000819","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.733210325241089}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.0830414295196533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0468878746032715}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-01-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.32"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.180698871612549}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000820","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1143693923950195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.20"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.530765533447266}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.37","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.37"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}},{"name":"BA.5.1.36","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.36"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}}]}]}]},{"name":"NODE_0000821","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024465799331665}},"branch_attrs":{"mutations":{"nuc":["G16935A","G28681T"],"N":["E136D"],"ORF1b":["M1156I"]},"labels":{"aa":"N: E136D; ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.024465799331665}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000822","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295308589935303}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.295308589935303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000823","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"immune_escape":{"value":"0.8224959014481948"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.49383999999999995"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000824","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0000825","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000826","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708206176757812}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.7708206176757812}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000827","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000828","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036677837371826}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.036677837371826}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"immune_escape":{"value":"0.5680790723509552"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45205000000000006"},"placement_prior":{"value":-4.677975654602051}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000829","node_attrs":{"div":21,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3825254440307617}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.3825254440307617}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.3848819732666016}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4368510246276855}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.19","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"immune_escape":{"value":"0.7257362514460642"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6127800000000001"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.17","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-4.728248119354248}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"immune_escape":{"value":"0.8308113969466171"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5446"},"placement_prior":{"value":-4.456897258758545}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6570799999999999"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.423923492431641}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.428438186645508}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.936223268508911}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.945977210998535}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4588370323181152}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.915694236755371}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.6576948165893555}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000830","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-26"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000831","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000832","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000833","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865875720977783}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.865875720977783}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000834","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009591579437256}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.068519592285156}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000837","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.709598541259766}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.709598541259766}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000838","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000839","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4316978454589844}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}},{"name":"BQ.1.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0000841","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"immune_escape":{"value":"0.6853534127590314"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6353800000000001"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EC.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.687568426132202}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"internal_dbfb","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"immune_escape":{"value":"0.6925976779449897"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5174000000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000846","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"immune_escape":{"value":"0.9874397743924017"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66664"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000847","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-04-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":31},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"immune_escape":{"value":"1.0821590912755812"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:83-122"},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6059300000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7632393836975098}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.5457186698913574}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.451982259750366}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.056915760040283}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-4.627330780029297}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"BQ.1.8","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"internal_9a91","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000851","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3905270099639893}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-09-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-2.3905270099639893}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-3.889237880706787}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-4.534395694732666}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.146517276763916}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.6093573570251465}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.224153995513916}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9906511306762695}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7449699999999998"},"placement_prior":{"value":-4.06502103805542}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"immune_escape":{"value":"0.8728938682420008"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5921799999999998"},"placement_prior":{"value":-4.8411335945129395}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"placement_prior":{"value":-4.593058109283447}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8225154876708984}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.312097549438477}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.200605392456055}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.227291584014893}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9314393997192383}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.904665470123291}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.049081802368164}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6982169151306152}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.249353408813477}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.385838985443115}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.995295286178589}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.85848331451416}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.359898090362549}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.529128551483154}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.37760591506958}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.216671466827393}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.973445177078247}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.916758060455322}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.271931171417236}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.37089204788208}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.056057929992676}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.0179009437561035}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6361196041107178}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.841104507446289}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.239201068878174}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"immune_escape":{"value":"1.051732686328446"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"-0.04867000000000007"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.662373065948486}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.7189483642578125}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2001824378967285}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.2001824378967285}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.70602"},"placement_prior":{"value":-5.588834762573242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000853","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955062866210938}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9955062866210938}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"placement_prior":{"value":-4.9605021476745605}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000854","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09937858581543}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-19"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.09937858581543}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000855","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.933582067489624}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.7809853553771973}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.529773235321045}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000856","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500675678253174}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ET.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.596988677978516}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000858","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.477259159088135}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.477259159088135}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ES.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.674633979797363}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000859","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848482131958008}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.848482131958008}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-11-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.74371"},"placement_prior":{"value":-4.994816303253174}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.450014591217041}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.450014591217041}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.90073823928833}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000861","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"immune_escape":{"value":"0.9105813557217661"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66913"},"placement_prior":{"value":-4.2420334815979}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8017332553863525}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8017332553863525}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6774299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000863","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9086992740631104}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9086992740631104}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.79539680480957}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.999442100524902}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000864","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109678268432617}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.109678268432617}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000865","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.950040817260742}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ER.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.950040817260742}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000866","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.677121162414551}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.677121162414551}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.548750877380371}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.493981838226318}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000867","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000868","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000869","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6486151218414307}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.49","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.766873359680176}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.48","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.388899803161621}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"NODE_0000870","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131350517272949}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.131350517272949}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.47806978225708}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"immune_escape":{"value":"0.880706782961692"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.34834999999999994"},"placement_prior":{"value":-4.918065547943115}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.497538089752197}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.497538089752197}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.829411506652832}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.498441696166992}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.498441696166992}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.188002586364746}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.897397041320801}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000873","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.166533946990967}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000874","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.433859825134277}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.433859825134277}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.000488758087158}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.000488758087158}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.651236534118652}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.224048137664795}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"NODE_0000876","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{"nuc":["T7633C","C22314T","A24129G"],"S":["P251L","N856S"]},"labels":{"aa":"S: P251L, N856S","spike_mutations":"P251L, N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{}}},{"name":"EW.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1165571212768555}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302682876586914}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000879","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"NODE_0000880","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.684224605560303}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.684224605560303}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000881","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.281740188598633}},"branch_attrs":{"mutations":{"nuc":["C22314T","T23716C","A28834G"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000882","node_attrs":{"div":30,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-17"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000883","node_attrs":{"div":31,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4922783374786377}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.4922783374786377}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.184210777282715}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.1315507888793945}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.840254783630371}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.185059070587158}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.52209997177124}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}}]},{"name":"NODE_0000885","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.140864372253418}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.140864372253418}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.2411675453186035}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"EF.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.071333885192871}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"internal_bc60","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000887","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138623237609863}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.22083044052124}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127103328704834}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.127103328704834}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000889","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000890","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6995480060577393}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000891","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-7.322900772094727}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"DN.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000892","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858262062072754}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.858262062072754}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000893","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"immune_escape":{"value":"0.8990816968865659"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"2.05606"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"immune_escape":{"value":"0.8744814686582322"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6722600000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"immune_escape":{"value":"0.8771384492554943"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5626099999999999"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}}]}]}]}]}]}]}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1493752002716064}},"branch_attrs":{"mutations":{"nuc":["C1627T","A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.11","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7922699451446533}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000896","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000897","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0000898","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6984124183654785}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6984124183654785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000899","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6816165447235107}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.6816165447235107}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5279"},"placement_prior":{"value":-3.9799368381500244}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.17","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.17"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.486154556274414}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.19","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.18"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.092382907867432}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.30"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.33"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6034899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.5524344444274902}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9146859645843506}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.4910569190979004}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000900","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0925703048706055}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BF.14","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.14"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-3.080409288406372}},"branch_attrs":{"mutations":{"nuc":["C16726T"],"ORF1b":["H1087Y"]},"labels":{"aa":"ORF1b: H1087Y"}}},{"name":"BF.35","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.35"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I"}}}]},{"name":"NODE_0000901","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.864605188369751}},"branch_attrs":{"mutations":{"nuc":["T6979G","C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.1568257808685303}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.27"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3811821937561035}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000902","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278052806854248}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.278052806854248}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006015777587891}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.39"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.006015777587891}},"branch_attrs":{"mutations":{}}},{"name":"BF.39.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"immune_escape":{"value":"0.5959379308450252"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.33263"},"placement_prior":{"value":-5.380832195281982}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}}]},{"name":"internal_a7a7","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141679286956787}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.41"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.141679286956787}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.41.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000905","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5755422115325928}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5755422115325928}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.462975025177002}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000906","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.166617393493652}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}},{"name":"BF.11.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.292903900146484}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}}]}]},{"name":"NODE_0000907","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.768697738647461}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7897300720214844}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.28"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.266979217529297}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.36","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.36"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.462023973464966}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000908","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318153858184814}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.4318153858184814}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000909","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.138409376144409}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"immune_escape":{"value":"0.563032084337257"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.3218"},"placement_prior":{"value":-4.989957332611084}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.138409376144409}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000910","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1209073066711426}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.15"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.382307052612305}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.20"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.54063081741333}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000911","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.4587743282318115}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.16"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.25"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.29"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.740654468536377}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.34"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685426235198975}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.23"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337315082550049}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.48889999999999995"},"placement_prior":{"value":-4.257188320159912}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}},{"name":"BF.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.337315082550049}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000914","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.661623001098633}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.24"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6700644493103027}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000915","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160372257232666}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.160372257232666}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000916","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7555065155029297}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.592723846435547}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000917","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0702483654022217}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.266252517700195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000918","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.60558819770813}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000919","node_attrs":{"div":27,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-08"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}},{"name":"BF.5.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000920","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.604146718978882}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.42"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.3972127437591553}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.26"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.32"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.259809494018555}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.37"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-4.417163372039795}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.40"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.287785530090332}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"NODE_0000922","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238605976104736}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.238605976104736}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0000923","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.10","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.541252613067627}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.11","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.68569278717041}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5383856296539307}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.512576580047607}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6393200000000001"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.23","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.26","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.6","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.8","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.2593913078308105}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0000924","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}},{"name":"BF.7.16","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000925","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0000926","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.5.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}}]},{"name":"NODE_0000927","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}}]},{"name":"NODE_0000928","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000929","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}},{"name":"BF.7.4.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.3122615814208984}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}}]}]},{"name":"NODE_0000930","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000931","node_attrs":{"div":28,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"BF.7.14.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"NODE_0000932","node_attrs":{"div":29,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000933","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.632067918777466}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.23"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.815178394317627}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.182595252990723}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.40"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.992319107055664}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000934","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2570536136627197}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.743116855621338}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.628093719482422}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000935","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.856088161468506}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.26"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.856088161468506}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.26.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]},{"name":"NODE_0000936","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190079689025879}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.498506784439087}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.28","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.28"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2396790981292725}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.29","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.29"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.531044960021973}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.45","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.45"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5131699999999999"},"placement_prior":{"value":-4.9987969398498535}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.52"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.161417007446289}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.55"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9991252422332764}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.59"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.2738494873046875}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0000937","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.982447624206543}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.33"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.982447624206543}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.33.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"placement_prior":{"value":-4.402839660644531}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680324077606201}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.680324077606201}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]}]},{"name":"ORF1b1050_internal","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190079689025879}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3988919258117676}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.693638563156128}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.14"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7940964698791504}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.30"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-4.567533493041992}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.35","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.35"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.34","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.34"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5116825103759766}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.37"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.46013069152832}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.39"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.42"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.43"},"immune_escape":{"value":"0.5413273873731987"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5642800000000001"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.44"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.2824883460998535}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.46"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.53"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.239425182342529}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.54"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.244055271148682}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.58","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.58"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.236813068389893}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.57"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-3.7233779430389404}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.61","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.61"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.716227054595947}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.62","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.62"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.200314521789551}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.63"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.8","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9480412006378174}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3595662117004395}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.32"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.365047454833984}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8121001720428467}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.27"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8121001720428467}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.27.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.800676345825195}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_a10d","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.362414836883545}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.38"},"immune_escape":{"value":"0.30660604695253"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.56458"},"placement_prior":{"value":-4.362414836883545}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.38.1"},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"placement_prior":{"value":-5.474380016326904}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_1651","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1829705238342285}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.36"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.1829705238342285}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.36.1"},"immune_escape":{"value":"0.7208595659836455"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4564899999999999"},"placement_prior":{"value":-5.6722588539123535}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"NODE_0000944","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.41"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.726003646850586}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.56"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.040581703186035}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329519748687744}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.47"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.329519748687744}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.47.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000946","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.104440450668335}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.104440450668335}},"branch_attrs":{"mutations":{}}},{"name":"BV.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.279457092285156}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}},{"name":"BV.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}}]},{"name":"NODE_0000947","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.469841718673706}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.469841718673706}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.597593307495117}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.597593307495117}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3.2"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.18593692779541}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.18593692779541}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-5.559307098388672}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31.2"},"immune_escape":{"value":"0.3253063676642168"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5594199999999998"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0000950","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064769744873047}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.51","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.51"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.50","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.50"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.740553379058838}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.60","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.60"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000951","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{}}},{"name":"CY.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}},{"name":"CY.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}}]},{"name":"NODE_0000952","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-4.205173015594482}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.3"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415544033050537}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.415544033050537}},"branch_attrs":{"mutations":{}}},{"name":"DB.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.356486797332764}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"NODE_0000955","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.993216037750244}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0000956","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665064811706543}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.665064811706543}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000957","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36299991607666}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.244806289672852}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000958","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.705625534057617}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000959","node_attrs":{"div":27,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}}]},{"name":"NODE_0000960","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8918910026550293}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2084972858428955}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.2084972858428955}},"branch_attrs":{"mutations":{}}},{"name":"CP.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.631740093231201}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.3"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.38661"},"placement_prior":{"value":-4.830904960632324}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.2"},"immune_escape":{"value":"0.5295255377787571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6942999999999999"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.5","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.982548236846924}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-03-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.8859148025512695}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"internal_7ebe","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}},{"name":"CP.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000963","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.436136245727539}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.436136245727539}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-5.384421348571777}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6003199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}},{"name":"CP.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.319474697113037}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}}]}]},{"name":"NODE_0000964","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071380138397217}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.071380138397217}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.241237163543701}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"NODE_0000965","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.080973148345947}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.080973148345947}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000966","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000864505767822}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.71883"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["R346T"]},"labels":{"aa":"ORF1a: S2797F; S: R346T","spike_mutations":"R346T"}}},{"name":"CK.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.711991310119629}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000967","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.605682373046875}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C25614T"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CK.1.5","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}},{"name":"CK.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}}]},{"name":"NODE_0000968","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021930694580078}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24129G"],"S":["Y144-","N856S"]},"labels":{"aa":"S: Y144-, N856S","spike_mutations":"Y144-, N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.657632350921631}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CK.1.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.021930694580078}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_36cf","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.372078895568848}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.5281758308410645}},"branch_attrs":{"mutations":{"nuc":["G22942T"],"S":["K460N"]},"labels":{"aa":"S: K460N","spike_mutations":"K460N"}}},{"name":"CK.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.372078895568848}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":29,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGALIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLRDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPFTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGSSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVIPTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPALPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYQKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKEGNFKNLREFVFKNIDGYFKIYSKHTPINLERDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFHEVFNATTFASVYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKPSGNYNYLYRLFRKSKLKPFERDISTEIYQAGNKPCNGVAGSNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"GTTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTTGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAGAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTTTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCAGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTTAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGACCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATACCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATACGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCGGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGCCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCAAAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAAGAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGAGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTCATGAAGTTTTTAACGCCACCACATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCATATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGCCTAGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAAGCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTCTAATTGTTACTCTCCTTTACAATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTTACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTGCGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/XBB/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/XBB/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/XBB/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/XBB/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/XBB/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/XBB/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/XBB/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/XBB/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{"nuc":["G1A","T44C","G405A","T9866C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A15451G","T15738C","C15939T","C16342T","C17859T","G19326A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21810T","A22000C","G22109C","A22200G","C22577G","C22599G","A22664C","C22895G","C22896T","A22898G","G22942T","C23019T","C23031T","A23040G","T25416C","G26275A","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["A11T"],"N":["E31-","R32-","S33-"],"ORF1a":["R47K","F3201L","S3675-","G3676-","F3677-"],"ORF1b":["S662G","P959S"],"ORF9b":["E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","A83V","Q146H","E183Q","E213G","H339D","T346R","I368L","P445V","S446G","K460N","S486F","S490F","Q493R"]},"labels":{"aa":"E: A11T; N: E31-, R32-, S33-; ORF1a: R47K, F3201L, S3675-, G3676-, F3677-; ORF1b: S662G, P959S; ORF9b: E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, A83V, Q146H, E183Q, E213G, H339D, T346R, I368L, P445V, S446G, K460N, S486F, S490F, Q493R","clade":"Omicron","spike_mutations":"L24-, P25-, P26-, A27S, A83V, Q146H, E183Q, E213G, H339D, T346R, I368L, P445V, S446G, K460N, S486F, S490F, Q493R"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.175270080566406}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAA","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAA"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAB","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAB"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.436409950256348}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAC","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAC"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAF"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAG","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAG"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAD","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAD"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.878465175628662}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAE","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAE"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAK","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAK"},"immune_escape":{"value":"0.3037714005953052"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAH","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAH"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.754757404327393}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAL","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAL"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAJ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAJ"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.642837047576904}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAM","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAM"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAP","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-07-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAP"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.004575729370117}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAN","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAN"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.080811023712158}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAR","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAR"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.452944755554199}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAQ","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAQ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAS","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAS"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.454671859741211}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAT","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAT"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.875851154327393}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAU","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAU"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.1733574867248535}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAV","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAV"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.717791557312012}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":82,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAW"},"immune_escape":{"value":"0.274687314409391"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E156-","F157-","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAZ","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAZ"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.731168270111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":4},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBA"},"immune_escape":{"value":"0.29808642936638835"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBD"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBE"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.574315547943115}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBH"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBG","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBG"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBN","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBN"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBM","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBM"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBP","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBP"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBR"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBS"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBT"},"immune_escape":{"value":"0.5037920175803539"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBQ"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBU","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBU"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBW"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBV"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBY","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBY"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCA"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XBZ","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBZ"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-04-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCB"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCD"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCC","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCC"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCE"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCG"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCJ"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCM","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCM"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCN"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCL","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCL"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCK","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCK"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCS","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCS"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCR","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCR"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCP","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCP"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCQ","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCQ"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCU","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCU"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCV"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCY","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCY"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCZ","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCZ"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XCW","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCW"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XDB","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDB"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XDC","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDC"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDE"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDF"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDH"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDG"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDJ","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDJ"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDL","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDL"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDM","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDM"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDN","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDN"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDS","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDS"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDT"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDU","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDU"},"immune_escape":{"value":"0.9475349114594978"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDW"},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XE","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":48},"designation_date":{"value":"2022-03-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XE"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEA","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEA"},"immune_escape":{"value":"1.2268340125514634"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDY","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDY"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDZ","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDZ"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEB","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEB"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XED"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":17.361},"partiallyAliased":{"value":"XED"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEE","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEE"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.853520393371582}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":950.694},"partiallyAliased":{"value":"XEG"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":9},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XG"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XEF","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":34.028},"partiallyAliased":{"value":"XEF"},"immune_escape":{"value":"1.7268345560655398"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XH","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XH"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XJ","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XJ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XK","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":45},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XK"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XM","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":46},"designation_date":{"value":"2022-03-31"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XM"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.152749061584473}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XL","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XL"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XP","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XP"},"immune_escape":{"value":"0.3616394203564539"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"placement_prior":{"value":-3.0006814002990723}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XN","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XN"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.342913627624512}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XQ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XQ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.5721659660339355}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XR","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XR"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XT","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XT"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.091723442077637}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XV","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XV"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.536415100097656}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XU","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XU"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XW","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-05-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XW"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XZ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XZ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.090399742126465}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XY"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBK.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBK.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBK"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCH.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCH.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCH"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCT.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCT"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDA.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDA.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDA"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEC.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":29.34},"partiallyAliased":{"value":"XEC.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":34.028},"partiallyAliased":{"value":"XEC"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"XDR.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}},{"name":"XDR.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.3.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.0838518142700195}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.0838518142700195}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49430513381958}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.2"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.1974196434021}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.1.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDQ.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.2"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.3"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.4"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":37,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.1.1"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.2","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"XDD.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.5"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XDK.4.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.4.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.4.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"NODE_0000032","node_attrs":{"div":61,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"internal_0d74e965","node_attrs":{"div":62,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.10"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.10"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.3"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.4"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.5"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.6"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.9","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.9"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.9"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.7"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.7.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.7.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.8"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.8.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.8.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":56,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.997220516204834}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.697917461395264}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":60,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":62,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"XAY.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000046","node_attrs":{"div":63,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":64,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":65,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.682618141174316}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"immune_escape":{"value":"0.752889267417711"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"placement_prior":{"value":-4.494446754455566}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"XDV.1.10"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.11"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.4","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.5"},"immune_escape":{"value":"1.5359962252743784"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.14808999999999992"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":6.25},"partiallyAliased":{"value":"XDV.1.2.1"},"immune_escape":{"value":"1.8051577060608006"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.26874999999999993"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}}]},{"name":"NODE_0000052","node_attrs":{"div":61,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.7"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"XDV.1.7.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000053","node_attrs":{"div":60,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.9.1"},"immune_escape":{"value":"1.5422010449483097"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20783000000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":68,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC"},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":68,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":58},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"XBC.2"},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.2.1"},"immune_escape":{"value":"0.44507236664312827"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000057","node_attrs":{"div":70,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":57},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"XBC.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":76,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.4"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":75,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.5"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000059","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.2.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":78,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":79,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}},{"name":"XBC.1.1.1","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1.1"},"immune_escape":{"value":"0.48837241784414276"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":76,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":76,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7.1"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7.2"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":79,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.1","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.3","node_attrs":{"div":81,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":83,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.4"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":84,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":84,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":87,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.4"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":88,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.5"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":85,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":88,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":87,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":89,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.6.1"},"immune_escape":{"value":"0.7550301657183831"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":87,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.6"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":86,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":86,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":89,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.1","node_attrs":{"div":92,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"immune_escape":{"value":"0.7420325830319254"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1.2","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1.3","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.207023620605469}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.390348434448242}},"branch_attrs":{"mutations":{"nuc":["C14178T","-29759G"]}}},{"name":"XBB.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.654644012451172}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.4"},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.3064099999999999"},"placement_prior":{"value":-4.654644012451172}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.4.1"},"immune_escape":{"value":"1.0810114368008295"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.26627999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000075","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.232290267944336}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.6.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C14178T","C14362T","C14574T","C22792A","C25539T"]}}},{"name":"XBB.8.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.479925632476807}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.479925632476807}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"NODE_0000080","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.121950149536133}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.121950149536133}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.148683547973633}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.256861209869385}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"NODE_0000081","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.453329563140869}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.453329563140869}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.11.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000082","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219453811645508}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.219453811645508}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.7.1"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65097"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.83268404006958}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"internal_d796","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.6","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"NODE_0000086","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":34,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.717053174972534}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-3.717053174972534}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.14"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.8983306884765625}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.20"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.18"},"immune_escape":{"value":"1.2567103717994188"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.0750199999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.22"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.21"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-12"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"placement_prior":{"value":-4.42367696762085}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.45538854598999}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.9"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.674048900604248}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"placement_prior":{"value":-4.709936141967773}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"placement_prior":{"value":-4.674048900604248}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"placement_prior":{"value":-4.8618388175964355}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.13"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.033972263336182}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"immune_escape":{"value":"1.0527558336884004"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84789"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.12"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.90647"},"placement_prior":{"value":-4.900045394897461}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.16"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.17"},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}},{"name":"JY.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"immune_escape":{"value":"0.9736186906064397"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89932"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.646721839904785}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.646721839904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.761235237121582}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000102","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"immune_escape":{"value":"1.0079043361863298"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.7709600000000001"},"placement_prior":{"value":-4.985507965087891}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.606808662414551}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.55094575881958}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.517807483673096}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.703529357910156}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.703529357910156}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.552662372589111}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.8","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_bb69915a","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.388531684875488}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}},{"name":"HH.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.4304351806640625}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.4304351806640625}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.898563385009766}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.898563385009766}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8265013694763184}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.568424701690674}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"immune_escape":{"value":"0.986824739722089"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.70075"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"GE.1.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000120","node_attrs":{"div":45,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":49,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":50,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.253464221954346}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.253464221954346}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.2032599449157715}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"GJ.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.6877522468566895}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-02"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.6877522468566895}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000130","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.5","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":47,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":48,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.052709102630615}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1.10","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.10"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13558"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.052709102630615}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.3","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.3"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.49564"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0545"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.49"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.89405"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.535830020904541}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.20"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.48"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.9722600000000003"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3403778076171875}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.3403778076171875}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":41,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"GW.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}}]},{"name":"NODE_0000141","node_attrs":{"div":46,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":48,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":48,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":54,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.3","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1255195140838623}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86729"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.27"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.2602599999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.29"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.36"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-5.3860321044921875}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.40"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.885027885437012}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.12"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.12.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.12.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.709931373596191}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-4.709931373596191}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.13.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.15"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.15.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000149","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.14.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.14.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_18e1f6df","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.220515251159668}},"branch_attrs":{"mutations":{"nuc":["G709T","T13704C"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.32.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.32","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.220515251159668}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.37.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.37.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.928167819976807}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.38"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.928167819976807}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.38.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.066565036773682}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.254011631011963}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.43"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.254011631011963}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.43.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.43.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344058036804199}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.44"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.344058036804199}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.44.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.44.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.038851737976074}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.45"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.038851737976074}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.45.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.45.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000156","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31.1"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31.2"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.7139763832092285}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.7139763832092285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-25"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.9892516136169434}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.34","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.569494247436523}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.05231"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000161","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.810415744781494}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.085368633270264}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"FW.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-4.810415744781494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000162","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.343214511871338}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.343214511871338}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962552070617676}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.962552070617676}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.714374542236328}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000167","node_attrs":{"div":38,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000168","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.7388600000000002"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69644832611084}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.69644832611084}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.357577323913574}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.357577323913574}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.77537202835083}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000173","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":40,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"NODE_0000175","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6362106800079346}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.079745769500732}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.30","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.30"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.744277477264404}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.069783687591553}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.46"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.47"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.47.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.47.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000177","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.1"},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.05408"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000178","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"NODE_0000179","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.73932409286499}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"placement_prior":{"value":-6.73932409286499}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.2"},"immune_escape":{"value":"1.1099290580037755"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6066099999999999"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000181","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000183","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000184","node_attrs":{"div":40,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"internal_b1afb4e5","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.43418"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"NODE_0000187","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000188","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.089523792266846}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000189","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.10.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}}]},{"name":"NODE_0000190","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000191","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.96117"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000193","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.2.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80721"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}}]}]},{"name":"NODE_0000194","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.90647"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000195","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000196","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000197","node_attrs":{"div":46,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7918386459350586}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7918386459350586}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.110"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.110"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.23376989364624}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.43"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.543598651885986}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.45"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.58"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.57"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.87"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.87"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93509"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873802423477173}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.062389373779297}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.873802423477173}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000200","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2794275283813477}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.101","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.101"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.101"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.10","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.10"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.755887031555176}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.104"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.104"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0973687171936035}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.109"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.109"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9660911560058594}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.653730630874634}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7371788024902344}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.007676124572754}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.29"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.41404999999999986"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.26","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4117631912231445}},"branch_attrs":{"mutations":{"nuc":["C920T"]}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.861788511276245}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.31"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8877837657928467}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.6405656337738037}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.063141822814941}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.282281398773193}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.36"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.254117965698242}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.40"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.95377"},"placement_prior":{"value":-4.218836784362793}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.51"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.948964834213257}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.52"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8478782176971436}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.54"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.59"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.107715606689453}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.63"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7518346309661865}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.62"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.189910888671875}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.64"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.1709489822387695}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.67"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7762694358825684}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.69"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.275579452514648}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.66"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.801894426345825}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.75"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.35540246963501}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.80"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.80"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.274980068206787}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.79"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.6546549797058105}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.82"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.82"},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.91194"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.85"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.85"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.914968967437744}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.98"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.98"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.99"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.99"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.521303653717041}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.97"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.97"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.439826965332031}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"NODE_0000201","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.362831115722656}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.174068450927734}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.362831115722656}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000202","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.663084030151367}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.396157264709473}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.663084030151367}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.7630462646484375}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.8095383644104}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.38"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.7630462646484375}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000204","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.283175945281982}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.7958831787109375}},"branch_attrs":{"mutations":{"nuc":["A11399G","T22930A"],"ORF1a":["M3712V"],"S":["F456L"]},"labels":{"aa":"ORF1a: M3712V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.86","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.283175945281982}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9230175018310547}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.943152904510498}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9230175018310547}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.136342525482178}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"immune_escape":{"value":"1.1023732112409157"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.29094"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.30"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.41123000000000004"},"placement_prior":{"value":-4.136342525482178}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738136291503906}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.92"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.738136291503906}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.4955267906188965}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.282939434051514}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.100"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4955267906188965}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7568650245666504}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-4.850849628448486}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.3"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-3.7568650245666504}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5239129066467285}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.971319675445557}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.107"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.5239129066467285}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.995249032974243}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-01-31"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.995249032974243}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000212","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.403249740600586}},"branch_attrs":{"mutations":{"nuc":["A22474C"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"XBB.1.5.105","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.105"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.105"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.108"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.108"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","C22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.400269508361816}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.50"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.71"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.48403999999999986"},"placement_prior":{"value":-4.380550861358643}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000214","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277669906616211}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"GC.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"immune_escape":{"value":"1.03073601411565"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9061"},"placement_prior":{"value":-4.990260124206543}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.277669906616211}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000215","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.036886692047119}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.036886692047119}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000216","node_attrs":{"div":41,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.7416800000000001"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.73864"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266819953918457}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.266819953918457}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"HP.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.286570072174072}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.286570072174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000220","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.9992594718933105}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.021956920623779}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.1186099999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.693673133850098}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.512119770050049}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.021956920623779}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000222","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000223","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000224","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000225","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}}]}]},{"name":"NODE_0000226","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000227","node_attrs":{"div":39,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000228","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576870918273926}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"immune_escape":{"value":"1.0346353162114479"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9873000000000001"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.174642086029053}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.576870918273926}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000229","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EK.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000230","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.037446975708008}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"HA.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.925134181976318}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"ORF1a":["G2868S","M3712V"]},"labels":{"aa":"ORF1a: G2868S, M3712V"}}},{"name":"NODE_0000231","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C920T","C21910A"]}},"children":[{"name":"EU.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":36,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}}]}]}]},{"name":"NODE_0000233","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.349449157714844}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.842705249786377}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.349449157714844}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000234","node_attrs":{"div":36,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000235","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.852022647857666}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.852022647857666}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425598621368408}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.425598621368408}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000239","node_attrs":{"div":42,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000241","node_attrs":{"div":42,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000242","node_attrs":{"div":44,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"immune_escape":{"value":"1.2868306565498102"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.20635"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000243","node_attrs":{"div":43,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376293182373}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"immune_escape":{"value":"1.3046787170970133"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.1261900000000002"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"NODE_0000244","node_attrs":{"div":41,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-22"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000245","node_attrs":{"div":43,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000249","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.4253100000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":44,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"internal_3ae12761","node_attrs":{"div":44,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000258","node_attrs":{"div":49,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000259","node_attrs":{"div":51,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":52,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"immune_escape":{"value":"1.3541583181563797"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.1446400000000003"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000261","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.413428544998169}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.106"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.106"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.20"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.676553726196289}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.188947677612305}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.27"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.5159149169921875}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.6741859912872314}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.098106384277344}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.56"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.201209545135498}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.60"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.6250386238098145}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.540223121643066}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.61"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.265577793121338}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.65"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.831235408782959}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.72"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.74"},"immune_escape":{"value":"1.0169257119491577"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9630099999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.76"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.102508068084717}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.78"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.81"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.81"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.628146171569824}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.449199199676514}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.83"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.83"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.5449676513671875}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.84"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.84"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.251712799072266}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.88"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.88"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.2988762855529785}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.89"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.89"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.153590202331543}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.90"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.90"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.91"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.91"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.224719524383545}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.94"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.94"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.448019504547119}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.96"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.96"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.11193323135376}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000262","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7867274284362793}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7867274284362793}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000263","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.83085"},"placement_prior":{"value":-4.0655517578125}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.42"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"immune_escape":{"value":"0.9838451476656441"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.83156"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.41"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185697078704834}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.135185718536377}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.48"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.185697078704834}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000266","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1880059242248535}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.218293190002441}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.103"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.1880059242248535}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9350799999999999"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000269","node_attrs":{"div":43,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8164870738983154}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.592982292175293}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.310765743255615}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8164870738983154}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000271","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000272","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]},{"name":"NODE_0000273","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"immune_escape":{"value":"1.0924169334128189"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.74638"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000278","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8006300926208496}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.89299"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8006300926208496}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}},{"name":"FD.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.37588357925415}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.37588357925415}},"branch_attrs":{"mutations":{}}},{"name":"FD.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}}]},{"name":"NODE_0000282","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.037048816680908}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.037048816680908}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.755037307739258}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.560482025146484}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.20585823059082}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.20585823059082}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000285","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000286","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"immune_escape":{"value":"0.950188045949472"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86018"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"immune_escape":{"value":"0.9788766097021935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.67693"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8926499999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"internal_77ad61e0","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}},{"name":"FY.5.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}}]},{"name":"NODE_0000303","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"NODE_0000304","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000305","node_attrs":{"div":39,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.996242046356201}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-2.996242046356201}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.11"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-3.181058645248413}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.12"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.10","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.10"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.275190353393555}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.14"},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.7388600000000002"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.16"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.17"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.18"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.089405059814453}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.19"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.20"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.22"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.21"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.23"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.24"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.25"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.26"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.1853718757629395}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.27"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.8"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.9"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000306","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.32"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000307","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"JM.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":40,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.29"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.30"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.31"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000310","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}}]}]},{"name":"NODE_0000311","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"internal_adf0d069","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121835708618164}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"JF.3","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"internal_398cc75a","node_attrs":{"div":47,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{}}},{"name":"JF.1.1.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.5","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"FU.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"2.14642"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}},{"name":"FU.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000318","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000319","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"NODE_0000320","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8164899999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.7","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.5","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000323","node_attrs":{"div":46,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}},{"name":"GY.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0856804847717285}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000325","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000326","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.941244125366211}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.210937023162842}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.210937023162842}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.6"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.13558"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000328","node_attrs":{"div":33,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.068836212158203}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"GD.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-4.331231594085693}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000329","node_attrs":{"div":34,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.389554500579834}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.063467979431152}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.233525276184082}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.18","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0403361320495605}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"FL.22","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.27","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.406124114990234}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.25","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.529069900512695}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.29","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.7904599999999999"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.216497898101807}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.7","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.6","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.937436103820801}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.164567947387695}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.9","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.411857604980469}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.389554500579834}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000330","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C6285T","G12907A","A27507C","C28770T"],"N":["T166I"],"ORF1a":["T2007I"]},"labels":{"aa":"N: T166I; ORF1a: T2007I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]},{"name":"NODE_0000331","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"immune_escape":{"value":"0.9957660361777405"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0848"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.30.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"NODE_0000336","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.33.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.515424728393555}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.33","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.35.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.917665481567383}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9744789600372314}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9744789600372314}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.5920999999999998"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"FL.10.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"immune_escape":{"value":"1.1216394663867173"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.98073"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000345","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000346","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.96117"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8835"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000347","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}},{"name":"FL.3.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.066182613372803}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}}]},{"name":"NODE_0000348","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282326698303223}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.282326698303223}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":35},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.671235084533691}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000353","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000354","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"internal_24b5ee08","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000356","node_attrs":{"div":41,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000357","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000358","node_attrs":{"div":48,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000359","node_attrs":{"div":49,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}},{"name":"KF.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}}]}]}]}]}]}]}]},{"name":"internal_7f0cfce5","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.670197010040283}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"FL.2.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_95ea4775","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.457831382751465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.93509"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"immune_escape":{"value":"1.0186868047371063"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.48144"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.3348299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000367","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"immune_escape":{"value":"0.9778643306477401"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.89211"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000372","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.06800999999999986"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000373","node_attrs":{"div":47,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{}}},{"name":"KC.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KC.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}}]}]},{"name":"NODE_0000374","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.36653995513916}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000375","node_attrs":{"div":46,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000376","node_attrs":{"div":47,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"immune_escape":{"value":"1.3005141566416802"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.0007299999999998658"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000377","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232717037200928}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000378","node_attrs":{"div":45,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000379","node_attrs":{"div":44,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000380","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.618598222732544}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.13","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.12","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.11","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.919648170471191}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.14","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.8","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"EG.7","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1186099999999999"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.618598222732544}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.20938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.397416591644287}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"placement_prior":{"value":-5.397416591644287}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000383","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000386","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.091670513153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.091670513153076}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.4","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317834377288818}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.317834377288818}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.169593811035156}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.346397876739502}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}},{"name":"EG.4.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.917497158050537}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3095011711120605}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000389","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541221857070923}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.541221857070923}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.088577747344971}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.5","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.569139003753662}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8091061115264893}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"EG.1.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.115445613861084}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}}]}]}]},{"name":"NODE_0000391","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173191070557}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000392","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"NODE_0000393","node_attrs":{"div":46,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000394","node_attrs":{"div":42,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.292908191680908}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.374487400054932}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.585853576660156}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000398","node_attrs":{"div":49,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-11-29"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"immune_escape":{"value":"1.4312755323086508"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.73257"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000399","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000400","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000402","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.3","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.8333635330200195}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9912302494049072}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.4253100000000001"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.4","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000403","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000404","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.10","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.025979999999999802"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.11","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"immune_escape":{"value":"1.3341105633249508"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.0887599999999999"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.4","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.3","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"immune_escape":{"value":"1.3005451981781486"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.21974"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.8","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.7","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043656826019287}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.048559999999999943"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"immune_escape":{"value":"1.3552393372267753"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.38161000000000006"},"placement_prior":{"value":-4.412596225738525}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000406","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000407","node_attrs":{"div":52,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000408","node_attrs":{"div":53,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000409","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"immune_escape":{"value":"1.1972306507819483"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.13706999999999997"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.19","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.21","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"immune_escape":{"value":"1.205901853206978"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.1481699999999999"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"immune_escape":{"value":"1.310148541751831"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.49366"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-11-27"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.31","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.25141716003418}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.30","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.32","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}},{"name":"HK.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"immune_escape":{"value":"1.2183176254438959"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.6088199999999999"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000416","node_attrs":{"div":51,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"immune_escape":{"value":"1.3534097328298118"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.48614000000000007"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000420","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.570084095001221}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.34.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"NODE_0000424","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2.1","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}},{"name":"HK.13.2","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.15","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.16","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"clade_membership":{"value":"23H"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_display":{"value":"23H (HK.3)"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.11","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.12","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.10","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.14","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.5","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.4","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.3","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.7","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.9","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.3123884201049805}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"clade_membership":{"value":"23H"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_display":{"value":"23H (HK.3)"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.15","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.15"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.830389499664307}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.16","node_attrs":{"div":1,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.16"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.232675552368164}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.19","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.19"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.5045647621154785}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.29116153717041}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":41},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.87.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.87.1"},"immune_escape":{"value":"0.6657453429914796"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.8217399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","C22000-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}},{"name":"BA.2.87","node_attrs":{"div":1,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.87"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.29116153717041}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.702070713043213}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":44},"designation_date":{"value":"2021-12-14"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.3"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.8285975456237793}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":46},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.807489812374115}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.9172141551971436}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":18},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.1.7"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.1350864171981812}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000434","node_attrs":{"div":63,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8541454076766968}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8541454076766968}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000435","node_attrs":{"div":66,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066986083984375}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066986083984375}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":83,"totalAminoacidDeletions":{"value":2},"totalAminoacidSubstitutions":{"value":19},"designation_date":{"value":"2021-04-21"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.617.2"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.5602865815162659}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E156-","F157-","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"A","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"A"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"A"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.94581937789917}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}},{"name":"B","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":0},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"internal_c0ce","node_attrs":{"div":1,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4849481582641602}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.9632513523101807}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.11"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"placement_prior":{"value":-4.008795738220215}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.18"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.06190824508667}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.20"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.934055805206299}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.24"},"immune_escape":{"value":"0.01261797446067892"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.03172000000000008"},"placement_prior":{"value":-3.048215866088867}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.28","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.28"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.9567365646362305}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.26","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.26"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.5785768032073975}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.27","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.27"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9515457153320312}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.29","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.29"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2466073036193848}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.30","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.30"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.192726135253906}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.32"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7269387245178223}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.39","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-05-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.39"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.341081619262695}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.4","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.4"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7649905681610107}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.42","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.42"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.41","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.41"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.732407331466675}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.46"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.784368991851807}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.43","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.43"},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"placement_prior":{"value":-4.411663055419922}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.5","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.5907039642333984}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.48","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.48"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7901194095611572}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.50"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.213821887969971}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.55"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.216464519500732}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.54","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.54"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.137808799743652}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.58"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.060901165008545}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.59","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.59"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.600815296173096}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.61","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.61"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.497117042541504}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.62"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.002071380615234}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.60","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.60"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.64","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.64"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.522981643676758}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.63","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.63"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.172652721405029}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.65","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.65"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.866844415664673}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.70","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.70"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.473325729370117}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.77"},"immune_escape":{"value":"0.3221048136122174"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9213199999999999"},"placement_prior":{"value":-5.606687545776367}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.8"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.326139450073242}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.82","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.82"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.82"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-5.217201232910156}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.83"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.83"},"immune_escape":{"value":"0.22071783986880583"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.12534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.85"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.85"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.306359767913818}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000438","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565203905105591}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.565203905105591}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.2.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000439","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1365203857421875}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.23"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1365203857421875}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.23.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.825143814086914}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.31.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.869024753570557}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.31","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.31"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.825143814086914}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000441","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8949601650238037}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.33"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.087352275848389}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}},{"name":"BA.2.35","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-29"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.35"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"placement_prior":{"value":-4.571066856384277}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020925521850586}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.40.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.40.1"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.7483084201812744}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.40","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.40"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8020925521850586}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000443","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.982405185699463}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.56.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.56.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.698922157287598}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}},{"name":"BA.2.56","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.56"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-2.982405185699463}},"branch_attrs":{"mutations":{}}}]},{"name":"BA.2.10_internal","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.6351211071014404}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.6351211071014404}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.685215473175049}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.082213878631592}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.4"},"immune_escape":{"value":"0.3166622371297313"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.73328"},"placement_prior":{"value":-5.095425605773926}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4718618392944336}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.4718618392944336}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.1.1"},"immune_escape":{"value":"0.6181860283242497"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.09519000000000005"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000446","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.908740520477295}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.14"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.693842649459839}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.22"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2798104286193848}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.34"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.117501735687256}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.36"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.0866947174072266}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.47","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.47"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.130222797393799}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.49"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8066627979278564}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.51","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.51"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7612979412078857}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.52"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8890013694763184}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.6","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.6"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.6700806617736816}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.69"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.045757293701172}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.7","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.384455680847168}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.72","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.72"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7303617000579834}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.71","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.71"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.731685161590576}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.81","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.81"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.81"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.353763580322266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.80","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.80"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.80"},"immune_escape":{"value":"0.31190394480802347"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10838000000000005"},"placement_prior":{"value":-5.6476006507873535}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.25"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.25.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.996367454528809}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"NODE_0000448","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.908740520477295}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.45","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-23"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.45"},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.30756000000000006"},"placement_prior":{"value":-3.734736680984497}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.53","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.53"},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.33552999999999994"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.7460718154907227}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.44"},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"placement_prior":{"value":-4.219630718231201}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5670673847198486}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.13"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-3.5670673847198486}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.13.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.0240631103515625}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1937501430511475}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.1937501430511475}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.3531692028045654}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.4"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.628756284713745}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2406184673309326}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.6"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.506667613983154}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.828467607498169}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000452","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.4851491451263428}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.10","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.10"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.09907865524292}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1285204887390137}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.4851491451263428}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.11"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7979793548583984}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.14"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.958454132080078}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.13"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.348191499710083}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.12"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.15"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8729355335235596}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.17"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8992807865142822}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.18"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.462960243225098}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.19"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-4.702410697937012}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.4"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.302166938781738}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8020241260528564}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.9"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8521687984466553}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.8"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"internal_305a","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.16"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.16.1"},"immune_escape":{"value":"0.43687237373984505"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9456899999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601692199707031}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.21"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06758"},"placement_prior":{"value":-4.830438613891602}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.21.1"},"immune_escape":{"value":"0.4733677107846063"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9683399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000455","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17173957824707}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.6","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.6"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.009570121765137}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}},{"name":"BA.2.3.22","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.22"},"immune_escape":{"value":"0.42289430257523936"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.37526000000000004"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}}]},{"name":"internal_019b","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9328737258911133}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9328737258911133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000457","node_attrs":{"div":29,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"immune_escape":{"value":"0.6029918987948071"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.6589000000000002"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-09-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1"},"immune_escape":{"value":"0.49181526572268314"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.66194"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"immune_escape":{"value":"0.4975483601650658"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.66821"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000458","node_attrs":{"div":26,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.10"},"immune_escape":{"value":"0.7593324873420084"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.8190299999999999"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000459","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.4"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"immune_escape":{"value":"0.7016283989012374"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.91683"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.6"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"immune_escape":{"value":"0.8143059671640498"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9440299999999998"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8"},"immune_escape":{"value":"0.7255583352017505"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.99403"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000463","node_attrs":{"div":30,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000464","node_attrs":{"div":31,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000465","node_attrs":{"div":35,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"immune_escape":{"value":"1.0761544902802131"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.28625999999999996"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.11","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.11"},"immune_escape":{"value":"1.0179803928276123"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.35566999999999993"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.12","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.12"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.3","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.3"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.9"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.2"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000468","node_attrs":{"div":29,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000469","node_attrs":{"div":30,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"immune_escape":{"value":"0.9785485534494837"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9729599999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1254796981811523}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.17"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.11018180847168}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.21"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.37"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.095773220062256}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.57"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.153290271759033}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.66"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.675938129425049}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.68"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.929081678390503}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.73"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.0335774421691895}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-23"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.74"},"immune_escape":{"value":"0.33134042675697756"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.21698000000000003"},"placement_prior":{"value":-3.8886899948120117}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.78"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.664786338806152}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000471","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0964372158050537}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.67"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000472","node_attrs":{"div":6,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.79"},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.79.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.79.1"},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000473","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.63395619392395}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-3.63395619392395}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000474","node_attrs":{"div":6,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76.1"},"immune_escape":{"value":"0.2640232066165751"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.18492"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}},{"name":"BA.2.76.2","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76.2"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4425623416900635}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.4425623416900635}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.741132736206055}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.3"},"immune_escape":{"value":"0.07383293656037815"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.08445999999999997"},"placement_prior":{"value":-4.741132736206055}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.3.1"},"immune_escape":{"value":"0.370455061085298"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.11188000000000006"},"placement_prior":{"value":-4.580904006958008}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000477","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.986060619354248}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.1"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.085832118988037}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000478","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.909948348999023}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.2"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.4"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.449790954589844}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7789523601531982}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7789523601531982}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.2"},"immune_escape":{"value":"0.062348652344665065"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07350000000000005"},"placement_prior":{"value":-3.9584996700286865}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"clade_membership":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0569682121276855}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.0569682121276855}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000481","node_attrs":{"div":7,"clade_membership":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292356729507446}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.2","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-06-18"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.2"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.0345394611358643}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.3","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.3"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.5","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-28"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.5"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.4","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.4"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.6","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-01"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.6"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}},{"name":"BG.7","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.7"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":18,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8684661388397217}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-3.8684661388397217}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.10"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.499698162078857}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.7"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-4.55503511428833}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.8"},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04854"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.7365007400512695}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.9"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.7365007400512695}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.9.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"placement_prior":{"value":-4.5146331787109375}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4"},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.13451"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000485","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.2"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"placement_prior":{"value":-3.378986120223999}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.3"},"immune_escape":{"value":"0.5588825437629772"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.24593"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000487","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"immune_escape":{"value":"0.7451886007636047"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.12575999999999996"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000488","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.4"},"immune_escape":{"value":"0.5013910005227346"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.10514"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000489","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}},{"name":"BR.5","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.5"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.099649429321289}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.099649429321289}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.4"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000491","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210728168487549}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.5"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.16854"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000492","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.586776256561279}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.586776256561279}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.043233394622803}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000493","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.19193"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.3464399999999999"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"immune_escape":{"value":"0.6011952983295785"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.56756"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.6"},"immune_escape":{"value":"0.5544855553668998"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.11979"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.636732578277588}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.636732578277588}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.278948783874512}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.278948783874512}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.083024501800537}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}},{"name":"BY.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-5.083024501800537}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_147e","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{}}},{"name":"CA.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.2"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"placement_prior":{"value":-4.7165374755859375}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.4","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.4"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.5"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.7"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.6"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.2371799999999999"},"placement_prior":{"value":-4.580175399780273}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096994400024414}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.096994400024414}},"branch_attrs":{"mutations":{}}},{"name":"BN.5","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.5"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.532908916473389}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"BN.6","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.6"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.629100322723389}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.4","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.4"},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"placement_prior":{"value":-4.784391403198242}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"internal_40f9","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215889930725098}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}},{"name":"BN.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.2"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-5.215889930725098}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.3"},"immune_escape":{"value":"0.5060716304521155"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.11385"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"immune_escape":{"value":"0.653690335850791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08339"},"placement_prior":{"value":-3.9134323596954346}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}}]},{"name":"NODE_0000503","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.74121356010437}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.74121356010437}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.221138954162598}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.97773551940918}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.7","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"immune_escape":{"value":"0.9193315170816834"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.5340599999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000504","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"BN.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000505","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"immune_escape":{"value":"0.7470314258752732"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1331"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"immune_escape":{"value":"0.7815531080803261"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.31233"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000507","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000508","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.136174201965332}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.220160484313965}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000510","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"immune_escape":{"value":"0.7326886306518271"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.21326"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000511","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000512","node_attrs":{"div":31,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"FR.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"NODE_0000513","node_attrs":{"div":35,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49798059463501}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-5.060053825378418}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"immune_escape":{"value":"1.0513083167390975"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.16291"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.12","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.856032848358154}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.576071739196777}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.3","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}},{"name":"EJ.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.13","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-06"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.11","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.791740894317627}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000520","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.306234359741211}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.306234359741211}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-5.302023887634277}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.5","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.5"},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"placement_prior":{"value":-5.031914234161377}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.6"},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"internal_42af","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.044631481170654}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.044631481170654}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"immune_escape":{"value":"0.5272935807019111"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.26994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.549932479858398}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.78817"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-08-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000525","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458258628845215}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}},{"name":"BM.1.1.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}}]},{"name":"internal_f6c6","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.43724"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000528","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"immune_escape":{"value":"0.9457248359372292"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.87567"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.26216459274292}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000529","node_attrs":{"div":28,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000530","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000531","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-06"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}},{"name":"CV.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000532","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000533","node_attrs":{"div":29,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000534","node_attrs":{"div":35,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000535","node_attrs":{"div":39,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000539","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852804660797119}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.0219999999999998"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"immune_escape":{"value":"0.7685109779549473"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.36891999999999997"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000542","node_attrs":{"div":25,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000543","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":69},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"CH.1.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"immune_escape":{"value":"0.9441222497200389"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:59-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.08511000000000003"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000544","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000545","node_attrs":{"div":31,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000546","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000547","node_attrs":{"div":29,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000548","node_attrs":{"div":31,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"DV.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000555","node_attrs":{"div":40,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000556","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}},{"name":"JV.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}}]}]},{"name":"NODE_0000559","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000560","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000561","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000562","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000563","node_attrs":{"div":27,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}},{"name":"GP.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0000564","node_attrs":{"div":27,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462465286255}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000565","node_attrs":{"div":30,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000566","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000567","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000568","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":34},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":34},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000570","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-31"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000572","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000574","node_attrs":{"div":37,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-04-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"immune_escape":{"value":"0.9815994835819151"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.16085999999999998"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000577","node_attrs":{"div":43,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000578","node_attrs":{"div":50,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.659756660461426}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-08-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.659756660461426}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.4"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.5"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000579","node_attrs":{"div":52,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}},{"name":"LV.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}}]},{"name":"NODE_0000580","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-06-13"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.7"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000581","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.7.1"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"immune_escape":{"value":"1.6738025507980547"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.12555999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000582","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000583","node_attrs":{"div":56,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-03-05"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2"},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.15919"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000584","node_attrs":{"div":60,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-03-20"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000585","node_attrs":{"div":52,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.786079406738281}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.4"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.519155979156494}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000586","node_attrs":{"div":53,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.825652837753296}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-3.825652837753296}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.12"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.16","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.16"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.14","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.14"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.15","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.15"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.17","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.17"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.18","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.18"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.19","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.19"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.6"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.7"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.8","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.8"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.9","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.9"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"NODE_0000587","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.11"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000588","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.13"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000589","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.5"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.6465599999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000590","node_attrs":{"div":55,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000591","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"ORF1a":["P892S"]},"labels":{"aa":"N: H300Y; ORF1a: P892S"}},"children":[{"name":"JN.3.2.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.3.2","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000592","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000593","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000594","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.369668006896973}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.10"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.502495765686035}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000595","node_attrs":{"div":58,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.788806915283203}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-09-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-2.788806915283203}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.12","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.26806999999999986"},"placement_prior":{"value":-5.217971324920654}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.10","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.4131927490234375}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.17","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9045615196228027}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.063985347747803}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.875726699829102}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.6741979122161865}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.28","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.40299129486084}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}}},{"name":"JN.1.3","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.494213581085205}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.493702411651611}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.403775691986084}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.0336198806762695}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.297048091888428}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.232478618621826}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.8044490814208984}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.11747407913208}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.342803478240967}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.61","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"immune_escape":{"value":"1.496607246855186"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.93036"},"placement_prior":{"value":-4.427524089813232}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.66","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"JN.1.67","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.554509162902832}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.108648300170898}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.108648300170898}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.2.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.971957206726074}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240912437438965}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-02-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"placement_prior":{"value":-5.240912437438965}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013584613800049}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.322965145111084}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.013584613800049}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.161866188049316}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.161866188049316}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.261717796325684}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844590663909912}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.844590663909912}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.38.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.392269611358643}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.392269611358643}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.43.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741122722625732}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.741122722625732}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.44.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.84599494934082}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5013346672058105}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.54.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"immune_escape":{"value":"1.532734695870142"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.05681999999999991"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}},{"name":"JN.1.54","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.5013346672058105}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906701564788818}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.56.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"immune_escape":{"value":"1.5395016697354735"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.7602899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.906701564788818}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803345680236816}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.803345680236816}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.59.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":8.507},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235188961029053}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.235188961029053}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.493972301483154}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000607","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.167296886444092}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.167296886444092}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.63.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.744463920593262}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.04854154586792}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.04854154586792}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250698566436768}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.250698566436768}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.39476203918457}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.39476203918457}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4552364349365234}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332151889801025}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.332151889801025}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.36.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.063086032867432}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005958557128906}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.005958557128906}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.993703842163086}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.40569543838501}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.40569543838501}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082462787628174}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.082462787628174}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.513469696044922}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.513469696044922}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.825034141540527}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"internal_b7e309e8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.62","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","G23604A"],"S":["V62F","R681H"]},"labels":{"aa":"S: V62F, R681H","spike_mutations":"V62F, R681H"}}},{"name":"NODE_0000620","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{"nuc":["G4162A","G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9000465869903564}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9000465869903564}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.853470325469971}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.175985336303711}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.564305782318115}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655609130859375}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9655609130859375}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.303173065185547}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-18"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ME.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.27215999999999985"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894876480102539}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.894876480102539}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.83441162109375}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.83441162109375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000629","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2595099999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}},{"name":"LN.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{}}},{"name":"MF.2","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}},{"name":"MF.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000632","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24034T","C24370T","A29700G"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000633","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"immune_escape":{"value":"1.3745641202332524"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.9318500000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000634","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000635","node_attrs":{"div":68,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343790531158447}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.343790531158447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000637","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548246383666992}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.548246383666992}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.693402290344238}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.1249308586120605}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566922187805176}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"NODE_0000642","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000644","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000645","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4388251304626465}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000646","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250442504883}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.617250442504883}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.769711017608643}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.769711017608643}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753198623657227}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"NODE_0000650","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-08-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":96},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}},{"name":"LU.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.396686553955078}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772514820098877}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.772514820098877}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.49.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.318779945373535}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.515067100524902}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000655","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":68,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.30217999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000657","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309075355529785}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.409302234649658}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.309075355529785}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.224586486816406}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872847080230713}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.872847080230713}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.486630439758301}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.534714698791504}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.534714698791504}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.343343257904053}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.343343257904053}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917464256286621}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.917464256286621}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2406325340271}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.9638495445251465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000664","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"placement_prior":{"value":-5.469202041625977}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.105811595916748}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.098007678985596}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.57.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.08313"},"placement_prior":{"value":-4.566637992858887}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.69068717956543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.287435054779053}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.175660133361816}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000671","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000672","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.04395"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.95433"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7120614051818848}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.7120614051818848}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.776768207550049}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.74375057220459}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.159214973449707}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000677","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.8164632320404053}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.098134517669678}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.037208080291748}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{}}},{"name":"KV.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}},{"name":"KV.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782661437988281}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.782661437988281}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000681","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769671440124512}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.769671440124512}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.145885944366455}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000682","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.528179883956909}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.528179883956909}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000684","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642605304718018}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.642605304718018}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.3354692459106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.97365140914917}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.97365140914917}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000689","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227312564849854}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.8855814933776855}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.850395679473877}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000690","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.5","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"KR.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000691","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":11.111},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000692","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.3","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"NODE_0000693","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0563764572143555}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.0563764572143555}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.607524394989014}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1424689292907715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.1424689292907715}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.6","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.8","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000696","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-24"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000697","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.662585735321045}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000699","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883163452148}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.111883163452148}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.472174167633057}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000701","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.347520351409912}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000702","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.716819763183594}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.0124382972717285}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_dc847259","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415851593017578}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.415851593017578}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.685051441192627}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.04741999999999978"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000706","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.079800128936768}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.079800128936768}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":50.174},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"immune_escape":{"value":"1.817229820305529"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21767999999999987"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-7.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000712","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671465873718262}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.671465873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000713","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000714","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000715","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}},{"name":"LF.8.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.091001987457275}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.091001987457275}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958034038543701}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.958034038543701}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","K182-","Q183-","G184-","N185-","F186-","N188Q","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, K182-, Q183-, G184-, N185-, F186-, N188Q, L189A","spike_mutations":"Y28H, K182-, Q183-, G184-, N185-, F186-, N188Q, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688790798187256}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.688790798187256}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.81335973739624}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-4.81335973739624}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-4.7956719398498535}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":11.111},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3926199999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994C","C21998-","A21999-","C22000-","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451901912689209}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.451901912689209}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.520982265472412}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}},{"name":"LQ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000725","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.054087162017822}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172401428222656}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.172401428222656}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"NODE_0000728","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}},{"name":"LZ.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000730","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}},{"name":"LZ.2.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.329638481140137}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.329638481140137}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.512091159820557}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.04741999999999978"},"placement_prior":{"value":-6.009568691253662}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000734","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.230648040771484}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.4.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"immune_escape":{"value":"1.7741516492587035"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.27333999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}},{"name":"KP.4.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]}]}]},{"name":"NODE_0000738","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.700614929199219}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-02-22"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.700614929199219}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.919792890548706}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.919792890548706}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.4","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"LP.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"NODE_0000743","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928211212158}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.200928211212158}},"branch_attrs":{"mutations":{}}},{"name":"internal_bfd296bd","node_attrs":{"div":67,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000745","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.814105272293091}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.814105272293091}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.616664409637451}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.439517021179199}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.12","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.083328723907471}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.0966644287109375}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"internal_1e4c8e87","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.2861931324005127}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"immune_escape":{"value":"1.7908990401504723"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"-0.40119000000000016"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000750","node_attrs":{"div":67,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":96},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000751","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.9114367961883545}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.21942999999999988"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.532774448394775}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.196527481079102}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.17","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.6","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.883235454559326}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.7","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000752","node_attrs":{"div":63,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9876158237457275}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9876158237457275}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.6","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.772136211395264}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.3.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094733715057373}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.094733715057373}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"immune_escape":{"value":"1.5554650921238282"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15242"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"NODE_0000755","node_attrs":{"div":68,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ML.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"ML.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ML.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9918503761291504}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9918503761291504}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.093895435333252}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-09"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.350859642028809}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":70,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000761","node_attrs":{"div":68,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000763","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"immune_escape":{"value":"1.7206397516519647"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.11924"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}},{"name":"MK.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000765","node_attrs":{"div":67,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.857026100158691}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.15","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.3","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.4","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.8321967124938965}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.6","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.7","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"immune_escape":{"value":"1.5369762101413171"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.3172000000000001"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"MC.11","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000767","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.637859344482422}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000771","node_attrs":{"div":5,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.49234676361084}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.49234676361084}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":6,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325173854827881}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.325173854827881}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000773","node_attrs":{"div":7,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.9142110347747803}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.3","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.5","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000774","node_attrs":{"div":10,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.2","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.2"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-05"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.71883"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000775","node_attrs":{"div":11,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.5.1"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.66094"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000776","node_attrs":{"div":7,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947638988494873}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.6947638988494873}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0240254402160645}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.100764274597168}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.872378349304199}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000777","node_attrs":{"div":8,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000778","node_attrs":{"div":9,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.11"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000779","node_attrs":{"div":11,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.10"},"immune_escape":{"value":"0.5308081831240151"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.67074"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.10.1"},"immune_escape":{"value":"0.7561969850799493"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5702799999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000780","node_attrs":{"div":13,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155839443206787}},"branch_attrs":{"mutations":{"nuc":["C1931A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF1a":["Q556K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF1a: Q556K; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.9592297077178955}},"branch_attrs":{"mutations":{"nuc":["A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}}},{"name":"BA.5.3","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.155839443206787}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":36},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:72-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7818877696990967}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.1","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.121390342712402}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":36},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"placement_prior":{"value":-3.2392046451568604}},"branch_attrs":{"mutations":{"nuc":["T1570C","A1931C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["K556Q","T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: K556Q, T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"BE.2","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.800013303756714}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T","G28681T"],"N":["E136D"],"ORF1a":["T882I"]},"labels":{"aa":"N: E136D; ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2200896739959717}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","G28681T","C28724T"],"N":["E136D","P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: E136D, P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.121390342712402}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"NODE_0000781","node_attrs":{"div":14,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.80837082862854}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.920682191848755}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.250558853149414}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}}]},{"name":"NODE_0000782","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9044742584228516}},"branch_attrs":{"mutations":{"nuc":["A1931C","A6551C","G29032A"],"ORF1a":["K556Q","M2096L"]},"labels":{"aa":"ORF1a: K556Q, M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3900210857391357}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000783","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.437628269195557}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A","G28681T"],"N":["E136D"],"S":["K444T","N460K"]},"labels":{"aa":"N: E136D; S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.10"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.9"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.6684834957122803}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000784","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2901611328125}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","G28681T","T28693C"],"N":["E136D"],"ORF1a":["M85-"]},"labels":{"aa":"N: E136D; ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.7371015548706055}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":95},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.394863128662109}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000785","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9449503421783447}},"branch_attrs":{"mutations":{"nuc":["A1931C","C21789T"],"ORF1a":["K556Q"],"S":["T76I"]},"labels":{"aa":"ORF1a: K556Q; S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.243032455444336}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"BA.5.5","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.9449503421783447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000786","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891446352005005}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}},{"name":"BA.5.5.1","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-3.5124127864837646}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}}]}]},{"name":"NODE_0000787","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.720151662826538}},"branch_attrs":{"mutations":{"nuc":["G28681T","T28693C"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BE.11","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.007559776306152}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"BE.12","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"NODE_0000788","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.232304573059082}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":95},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.13"},"immune_escape":{"value":"0.5088823627149919"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5231200000000001"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":94},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"BA.5.3.1.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":1},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T","G28681T"],"N":["E136D"],"ORF1a":["T3308N"]},"labels":{"aa":"N: E136D; ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000790","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2813496589660645}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000791","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"placement_prior":{"value":-3.919694185256958}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000793","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"CQ.1.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]}]}]}]}]},{"name":"NODE_0000794","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075937032699585}},"branch_attrs":{"mutations":{"nuc":["A1931C","T4906C","C17402T","T18957C","C21077T"],"ORF1a":["K556Q"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1a: K556Q; ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.075937032699585}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000795","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130266189575195}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5883099999999998"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000796","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3249030113220215}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.3249030113220215}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000797","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6570799999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000798","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.391442775726318}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}}]}]}]}]},{"name":"NODE_0000799","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2639026641845703}},"branch_attrs":{"mutations":{"nuc":["A1T","A1931C","T27438C","C29666T"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.2639026641845703}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.12"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.4234297275543213}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.14","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.14"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.9656171798706055}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.16"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9540679454803467}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.17"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.774606227874756}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2636609077453613}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.24"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3640329837799072}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.28"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.247698783874512}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.1495773792266846}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.30"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.902099132537842}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.34"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0658464431762695}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A21999-","C22000-","A22001-","A22002-","A22003-","A22004-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["H146-","K147-","N148H","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: H146-, K147-, N148H, P1162S","spike_mutations":"H146-, K147-, N148H, P1162S"}}},{"name":"BA.5.1.6","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.541465997695923}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.4","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.7","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8861465454101562}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.5","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.146693468093872}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.8","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.632486343383789}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0000800","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.10.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9345104694366455}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.15"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.15.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-3.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000802","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2127861976623535}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2127861976623535}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.22.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","T21994C","T21995-","A21996-","C21997-","C21998-","A21999-","C22000-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000803","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.26"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.26.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3030779361724854}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.38"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198533058166504}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.35"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.198533058166504}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.35.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000806","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415742874145508}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.33"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.415742874145508}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.33.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8465638160705566}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8465638160705566}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.115744113922119}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.33618688583374}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0000809","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.429936408996582}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.18"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000810","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069718837738037}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.069718837738037}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_b005","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.521807909011841}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.27"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0000814","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}},{"name":"CL.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]}]}]}]},{"name":"internal_2d50","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806924343109131}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.806924343109131}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.112699508666992}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-5.112699508666992}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000817","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.253764629364014}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-12-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000818","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"NODE_0000819","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.733210325241089}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.0830414295196533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0468878746032715}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-01-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.32"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.180698871612549}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000820","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1143693923950195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.20"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.530765533447266}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.37","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.37"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}},{"name":"BA.5.1.36","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.36"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}}]}]}]},{"name":"NODE_0000821","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024465799331665}},"branch_attrs":{"mutations":{"nuc":["G16935A","G28681T"],"N":["E136D"],"ORF1b":["M1156I"]},"labels":{"aa":"N: E136D; ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.024465799331665}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000822","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295308589935303}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.295308589935303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000823","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"immune_escape":{"value":"0.8224959014481948"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.49383999999999995"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000824","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0000825","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000826","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708206176757812}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.7708206176757812}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000827","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000828","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036677837371826}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.036677837371826}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"immune_escape":{"value":"0.5680790723509552"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45205000000000006"},"placement_prior":{"value":-4.677975654602051}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000829","node_attrs":{"div":21,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3825254440307617}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.3825254440307617}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.3848819732666016}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4368510246276855}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.19","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"immune_escape":{"value":"0.7257362514460642"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6127800000000001"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.17","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-4.728248119354248}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"immune_escape":{"value":"0.8308113969466171"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5446"},"placement_prior":{"value":-4.456897258758545}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6570799999999999"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.423923492431641}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.428438186645508}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.936223268508911}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.945977210998535}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4588370323181152}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.915694236755371}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.6576948165893555}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000830","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-26"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000831","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000832","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000833","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865875720977783}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.865875720977783}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000834","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009591579437256}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.068519592285156}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000837","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.709598541259766}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.709598541259766}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000838","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000839","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4316978454589844}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}},{"name":"BQ.1.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0000841","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"immune_escape":{"value":"0.6853534127590314"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6353800000000001"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EC.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.687568426132202}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"internal_dbfb","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"immune_escape":{"value":"0.6925976779449897"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5174000000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000846","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"immune_escape":{"value":"0.9874397743924017"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66664"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000847","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-04-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":31},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"immune_escape":{"value":"1.0821590912755812"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:83-122"},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6059300000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7632393836975098}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.5457186698913574}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.451982259750366}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.056915760040283}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-4.627330780029297}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"BQ.1.8","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"internal_9a91","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000851","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3905270099639893}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-09-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-2.3905270099639893}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-3.889237880706787}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-4.534395694732666}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.146517276763916}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.6093573570251465}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.224153995513916}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9906511306762695}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7449699999999998"},"placement_prior":{"value":-4.06502103805542}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"immune_escape":{"value":"0.8728938682420008"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5921799999999998"},"placement_prior":{"value":-4.8411335945129395}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"placement_prior":{"value":-4.593058109283447}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8225154876708984}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.312097549438477}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.200605392456055}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.227291584014893}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9314393997192383}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.904665470123291}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.049081802368164}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6982169151306152}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.249353408813477}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.385838985443115}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.995295286178589}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.85848331451416}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.359898090362549}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.529128551483154}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.37760591506958}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.216671466827393}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.973445177078247}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.916758060455322}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.271931171417236}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.37089204788208}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.056057929992676}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.0179009437561035}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6361196041107178}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.841104507446289}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.239201068878174}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"immune_escape":{"value":"1.051732686328446"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"-0.04867000000000007"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.662373065948486}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.7189483642578125}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2001824378967285}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.2001824378967285}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.70602"},"placement_prior":{"value":-5.588834762573242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000853","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955062866210938}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9955062866210938}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"placement_prior":{"value":-4.9605021476745605}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000854","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09937858581543}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-19"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.09937858581543}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000855","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.933582067489624}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.7809853553771973}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.529773235321045}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000856","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500675678253174}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ET.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.596988677978516}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000858","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.477259159088135}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.477259159088135}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ES.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.674633979797363}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000859","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848482131958008}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.848482131958008}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-11-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.74371"},"placement_prior":{"value":-4.994816303253174}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.450014591217041}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.450014591217041}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.90073823928833}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000861","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"immune_escape":{"value":"0.9105813557217661"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66913"},"placement_prior":{"value":-4.2420334815979}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8017332553863525}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8017332553863525}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6774299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000863","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9086992740631104}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9086992740631104}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.79539680480957}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.999442100524902}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000864","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109678268432617}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.109678268432617}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000865","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.950040817260742}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ER.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.950040817260742}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000866","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.677121162414551}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.677121162414551}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.548750877380371}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.493981838226318}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000867","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000868","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000869","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6486151218414307}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.49","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.766873359680176}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.48","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.388899803161621}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"NODE_0000870","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131350517272949}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.131350517272949}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.47806978225708}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"immune_escape":{"value":"0.880706782961692"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.34834999999999994"},"placement_prior":{"value":-4.918065547943115}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.497538089752197}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.497538089752197}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.829411506652832}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.498441696166992}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.498441696166992}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.188002586364746}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.897397041320801}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000873","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.166533946990967}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000874","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.433859825134277}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.433859825134277}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.000488758087158}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.000488758087158}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.651236534118652}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.224048137664795}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"NODE_0000876","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{"nuc":["T7633C","C22314T","A24129G"],"S":["P251L","N856S"]},"labels":{"aa":"S: P251L, N856S","spike_mutations":"P251L, N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{}}},{"name":"EW.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1165571212768555}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302682876586914}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000879","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"NODE_0000880","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.684224605560303}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.684224605560303}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000881","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.281740188598633}},"branch_attrs":{"mutations":{"nuc":["C22314T","T23716C","A28834G"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000882","node_attrs":{"div":30,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-17"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000883","node_attrs":{"div":31,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4922783374786377}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.4922783374786377}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.184210777282715}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.1315507888793945}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.840254783630371}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.185059070587158}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.52209997177124}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}}]},{"name":"NODE_0000885","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.140864372253418}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.140864372253418}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.2411675453186035}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"EF.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.071333885192871}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"internal_bc60","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000887","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138623237609863}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.22083044052124}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127103328704834}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.127103328704834}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000889","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000890","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6995480060577393}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000891","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-7.322900772094727}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"DN.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000892","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858262062072754}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.858262062072754}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000893","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"immune_escape":{"value":"0.8990816968865659"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"2.05606"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"immune_escape":{"value":"0.8744814686582322"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6722600000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"immune_escape":{"value":"0.8771384492554943"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5626099999999999"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}}]}]}]}]}]}]}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1493752002716064}},"branch_attrs":{"mutations":{"nuc":["C1627T","A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.11","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7922699451446533}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000896","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000897","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0000898","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6984124183654785}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6984124183654785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000899","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6816165447235107}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.6816165447235107}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5279"},"placement_prior":{"value":-3.9799368381500244}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.17","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.17"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.486154556274414}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.19","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.18"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.092382907867432}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.30"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.33"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6034899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.5524344444274902}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9146859645843506}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.4910569190979004}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000900","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0925703048706055}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BF.14","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.14"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-3.080409288406372}},"branch_attrs":{"mutations":{"nuc":["C16726T"],"ORF1b":["H1087Y"]},"labels":{"aa":"ORF1b: H1087Y"}}},{"name":"BF.35","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.35"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I"}}}]},{"name":"NODE_0000901","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.864605188369751}},"branch_attrs":{"mutations":{"nuc":["T6979G","C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.1568257808685303}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.27"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3811821937561035}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000902","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278052806854248}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.278052806854248}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006015777587891}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.39"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.006015777587891}},"branch_attrs":{"mutations":{}}},{"name":"BF.39.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"immune_escape":{"value":"0.5959379308450252"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.33263"},"placement_prior":{"value":-5.380832195281982}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}}]},{"name":"internal_a7a7","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141679286956787}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.41"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.141679286956787}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.41.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000905","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5755422115325928}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5755422115325928}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.462975025177002}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000906","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.166617393493652}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}},{"name":"BF.11.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.292903900146484}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}}]}]},{"name":"NODE_0000907","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.768697738647461}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7897300720214844}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.28"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.266979217529297}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.36","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.36"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.462023973464966}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000908","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318153858184814}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.4318153858184814}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000909","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.138409376144409}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"immune_escape":{"value":"0.563032084337257"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.3218"},"placement_prior":{"value":-4.989957332611084}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.138409376144409}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000910","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1209073066711426}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.15"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.382307052612305}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.20"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.54063081741333}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000911","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.4587743282318115}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.16"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.25"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.29"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.740654468536377}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.34"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685426235198975}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.23"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337315082550049}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.48889999999999995"},"placement_prior":{"value":-4.257188320159912}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}},{"name":"BF.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.337315082550049}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000914","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.661623001098633}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.24"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6700644493103027}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000915","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160372257232666}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.160372257232666}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000916","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7555065155029297}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.592723846435547}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000917","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0702483654022217}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.266252517700195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000918","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.60558819770813}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000919","node_attrs":{"div":27,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-08"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}},{"name":"BF.5.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000920","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.604146718978882}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.42"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.3972127437591553}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.26"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.32"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.259809494018555}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.37"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-4.417163372039795}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.40"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.287785530090332}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"NODE_0000922","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238605976104736}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.238605976104736}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0000923","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.10","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.541252613067627}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.11","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.68569278717041}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5383856296539307}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.512576580047607}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6393200000000001"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.23","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.26","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.6","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.8","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.2593913078308105}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0000924","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}},{"name":"BF.7.16","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000925","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0000926","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.5.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}}]},{"name":"NODE_0000927","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}}]},{"name":"NODE_0000928","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000929","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}},{"name":"BF.7.4.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.3122615814208984}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}}]}]},{"name":"NODE_0000930","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000931","node_attrs":{"div":28,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"BF.7.14.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"NODE_0000932","node_attrs":{"div":29,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000933","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.632067918777466}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.23"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.815178394317627}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.182595252990723}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.40"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.992319107055664}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000934","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2570536136627197}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.743116855621338}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.628093719482422}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000935","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.856088161468506}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.26"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.856088161468506}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.26.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]},{"name":"NODE_0000936","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190079689025879}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.498506784439087}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.28","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.28"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2396790981292725}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.29","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.29"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.531044960021973}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.45","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.45"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5131699999999999"},"placement_prior":{"value":-4.9987969398498535}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.52"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.161417007446289}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.55"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9991252422332764}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.59"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.2738494873046875}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0000937","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.982447624206543}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.33"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.982447624206543}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.33.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"placement_prior":{"value":-4.402839660644531}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680324077606201}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.680324077606201}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]}]},{"name":"ORF1b1050_internal","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190079689025879}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3988919258117676}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.693638563156128}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.14"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7940964698791504}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.30"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-4.567533493041992}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.35","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.35"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.34","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.34"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5116825103759766}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.37"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.46013069152832}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.39"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.42"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.43"},"immune_escape":{"value":"0.5413273873731987"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5642800000000001"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.44"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.2824883460998535}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.46"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.53"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.239425182342529}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.54"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.244055271148682}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.58","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.58"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.236813068389893}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.57"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-3.7233779430389404}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.61","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.61"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.716227054595947}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.62","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.62"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.200314521789551}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.63"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.8","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9480412006378174}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3595662117004395}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.32"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.365047454833984}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8121001720428467}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.27"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8121001720428467}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.27.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.800676345825195}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_a10d","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.362414836883545}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.38"},"immune_escape":{"value":"0.30660604695253"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.56458"},"placement_prior":{"value":-4.362414836883545}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.38.1"},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"placement_prior":{"value":-5.474380016326904}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_1651","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1829705238342285}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.36"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.1829705238342285}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.36.1"},"immune_escape":{"value":"0.7208595659836455"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4564899999999999"},"placement_prior":{"value":-5.6722588539123535}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"NODE_0000944","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.41"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.726003646850586}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.56"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.040581703186035}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329519748687744}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.47"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.329519748687744}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.47.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000946","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.104440450668335}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.104440450668335}},"branch_attrs":{"mutations":{}}},{"name":"BV.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.279457092285156}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}},{"name":"BV.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}}]},{"name":"NODE_0000947","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.469841718673706}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.469841718673706}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.597593307495117}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.597593307495117}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3.2"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.18593692779541}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.18593692779541}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-5.559307098388672}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31.2"},"immune_escape":{"value":"0.3253063676642168"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5594199999999998"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0000950","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064769744873047}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.51","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.51"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.50","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.50"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.740553379058838}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.60","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.60"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000951","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{}}},{"name":"CY.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}},{"name":"CY.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}}]},{"name":"NODE_0000952","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-4.205173015594482}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.3"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415544033050537}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.415544033050537}},"branch_attrs":{"mutations":{}}},{"name":"DB.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.356486797332764}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"NODE_0000955","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.993216037750244}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0000956","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665064811706543}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.665064811706543}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000957","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36299991607666}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.244806289672852}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000958","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.705625534057617}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000959","node_attrs":{"div":27,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}}]},{"name":"NODE_0000960","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8918910026550293}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2084972858428955}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.2084972858428955}},"branch_attrs":{"mutations":{}}},{"name":"CP.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.631740093231201}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.3"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.38661"},"placement_prior":{"value":-4.830904960632324}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.2"},"immune_escape":{"value":"0.5295255377787571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6942999999999999"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.5","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.982548236846924}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-03-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.8859148025512695}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"internal_7ebe","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}},{"name":"CP.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000963","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.436136245727539}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.436136245727539}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-5.384421348571777}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6003199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}},{"name":"CP.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.319474697113037}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}}]}]},{"name":"NODE_0000964","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071380138397217}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.071380138397217}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.241237163543701}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"NODE_0000965","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.080973148345947}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.080973148345947}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000966","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000864505767822}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.71883"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["R346T"]},"labels":{"aa":"ORF1a: S2797F; S: R346T","spike_mutations":"R346T"}}},{"name":"CK.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.711991310119629}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000967","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.605682373046875}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C25614T"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CK.1.5","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}},{"name":"CK.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}}]},{"name":"NODE_0000968","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021930694580078}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24129G"],"S":["Y144-","N856S"]},"labels":{"aa":"S: Y144-, N856S","spike_mutations":"Y144-, N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.657632350921631}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CK.1.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.021930694580078}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_36cf","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.372078895568848}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.5281758308410645}},"branch_attrs":{"mutations":{"nuc":["G22942T"],"S":["K460N"]},"labels":{"aa":"S: K460N","spike_mutations":"K460N"}}},{"name":"CK.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.372078895568848}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":29,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGALIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLRDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPFTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGSSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVIPTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPALPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYQKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKEGNFKNLREFVFKNIDGYFKIYSKHTPINLERDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFHEVFNATTFASVYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKPSGNYNYLYRLFRKSKLKPFERDISTEIYQAGNKPCNGVAGSNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"GTTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTTGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAGAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTTTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCAGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTTAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGACCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATACCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATACGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCGGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGCCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCAAAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAAGAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGAGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTCATGAAGTTTTTAACGCCACCACATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCATATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGCCTAGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAAGCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTCTAATTGTTACTCTCCTTTACAATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTTACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTGCGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/XBB/tree.json.bak b/data/nextstrain/sars-cov-2/XBB/tree.json.bak new file mode 100644 index 00000000..1309c4e9 --- /dev/null +++ b/data/nextstrain/sars-cov-2/XBB/tree.json.bak @@ -0,0 +1 @@ +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/XBB/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/XBB/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/XBB/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/XBB/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/XBB/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/XBB/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/XBB/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/XBB/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/XBB/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-04-21","#4235C0"],["2021-12-07","#539BB4"],["2021-12-14","#549DB2"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","designation_recency","clade_who","clade_display","designation_date"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":false},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":true},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{"nuc":["G1A","T44C","G405A","T9866C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A15451G","T15738C","C15939T","C16342T","C17859T","G19326A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21810T","A22000C","G22109C","A22200G","C22577G","C22599G","A22664C","C22895G","C22896T","A22898G","G22942T","C23019T","C23031T","A23040G","T25416C","G26275A","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["A11T"],"N":["E31-","R32-","S33-"],"ORF1a":["R47K","F3201L","S3675-","G3676-","F3677-"],"ORF1b":["S662G","P959S"],"ORF9b":["E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","A83V","Q146H","E183Q","E213G","H339D","T346R","I368L","P445V","S446G","K460N","S486F","S490F","Q493R"]},"labels":{"aa":"E: A11T; N: E31-, R32-, S33-; ORF1a: R47K, F3201L, S3675-, G3676-, F3677-; ORF1b: S662G, P959S; ORF9b: E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, A83V, Q146H, E183Q, E213G, H339D, T346R, I368L, P445V, S446G, K460N, S486F, S490F, Q493R","clade":"Omicron","spike_mutations":"L24-, P25-, P26-, A27S, A83V, Q146H, E183Q, E213G, H339D, T346R, I368L, P445V, S446G, K460N, S486F, S490F, Q493R"}},"children":[{"name":"BA.2","node_attrs":{"div":0,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.175270080566406}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289T","-11290T","-11291T","-11292T","-11293T","-11294T","-11295T","-11296T","-21633T","-21634T","-21635T","-21636T","-21637T","-21638T","-21639T","-21640T","-21641T","-28362T","-28363T","-28364T","-28365T","-28366T","-28367T","-28368T","-28369T","-28370T","-29734T","-29735T","-29736T","-29737T","-29738T","-29739T","-29740T","-29741T","-29742T","-29743T","-29744T","-29745T","-29746T","-29747T","-29748T","-29749T","-29750T","-29751T","-29752T","-29753T","-29754T","-29755T","-29756T","-29757T","-29758T","-29759T"]}},"children":[{"name":"XAA","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAA"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","A1610G","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C8247T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12445T","A19356G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","N449D","I842T","K856R","S1307G","S2083-","L2084I","S2661F","L3201F"]},"labels":{"aa":"ORF1a: R135S, N449D, I842T, K856R, S1307G, S2083-, L2084I, S2661F, L3201F"}}},{"name":"XAB","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-06-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAB"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.436409950256348}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17010T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F"}}},{"name":"XAC","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAC"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.852078437805176}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15720T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25731T","C25810T","C26028T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3G"],"ORF1a":["A2909V","L3201F"],"ORF3a":["L140F","I223T"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; ORF1a: A2909V, L3201F; ORF3a: L140F, I223T; ORF6: L61D"}}},{"name":"XAF","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAF"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","T3750I","V3751F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, T3750I, V3751F; ORF3a: H78Y"}}},{"name":"XAG","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAG"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C2857T","A4184G","T4321C","T5386G","C5585A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C17502T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22674C","C22792T","G22882T","T26270C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["I9T"],"ORF1a":["R135S","I842T","K856R","S1307G","L1774I","S2083-","L2084I","L3201F"],"S":["F371S","K440N"]},"labels":{"aa":"E: I9T; ORF1a: R135S, I842T, K856R, S1307G, L1774I, S2083-, L2084I, L3201F; S: F371S, K440N","spike_mutations":"F371S, K440N"}}},{"name":"XAD","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAD"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.878465175628662}},"branch_attrs":{"mutations":{"nuc":["A1250G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["T329A","L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: T329A, L3201F; ORF6: L61D"}}},{"name":"XAE","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAE"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4975A","A6390C","C9803T","C9866T","C11249T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22882T","T26060C","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28877T","G28878C","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29748C","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["E2042A","L3201F","R3662C"],"ORF3a":["I223T"],"ORF6":["L61D"],"S":["K440N"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: E2042A, L3201F, R3662C; ORF3a: I223T; ORF6: L61D; S: K440N","spike_mutations":"K440N"}}},{"name":"XAK","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAK"},"immune_escape":{"value":"0.3037714005953052"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4927T","T5386G","C7834T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A22001G","G22599A","G22882T","T22942G","G23040A","C24863T","G26577C","A27507G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["L3201F"],"ORF1b":["C1315R","I2163T"],"S":["I19T","-24L","-25P","-26P","S27A","H69-","V70-","K147E","R346K","K440N","N460K","R493Q","H1101Y"]},"labels":{"aa":"M: E19Q; ORF1a: L3201F; ORF1b: C1315R, I2163T; S: I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y","spike_mutations":"I19T, -24L, -25P, -26P, S27A, H69-, V70-, K147E, R346K, K440N, N460K, R493Q, H1101Y"}}},{"name":"XAH","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAH"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.754757404327393}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G17242T","C18246T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362G","T28363A","T28364G","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["-33G","R413S"],"ORF1b":["A1259S"],"ORF6":["L61D"],"ORF9b":["-27E"]},"labels":{"aa":"M: D3G; N: -33G, R413S; ORF1b: A1259S; ORF6: L61D; ORF9b: -27E"}}},{"name":"XAL","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAL"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A2865G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","G21586T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23604C","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","E867G","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"],"S":["L8F","H681P"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, E867G, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R; S: L8F, H681P","spike_mutations":"L8F, H681P"}}},{"name":"XAJ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAJ"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.642837047576904}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11674T","T15009C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","A23535G","C23673T","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["L3201F"],"S":["H69-","V70-","L452R","F486V","R493Q","N658S","S704L"]},"labels":{"aa":"ORF1a: L3201F; S: H69-, V70-, L452R, F486V, R493Q, N658S, S704L","spike_mutations":"H69-, V70-, L452R, F486V, R493Q, N658S, S704L"}}},{"name":"XAM","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAM"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11514T","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T22813G","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","L3201F","T3750I"],"ORF3a":["H78Y"],"S":["-24L","-25P","-26P","S27A","N417K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, L3201F, T3750I; ORF3a: H78Y; S: -24L, -25P, -26P, S27A, N417K","spike_mutations":"-24L, -25P, -26P, S27A, N417K"}}},{"name":"XAP","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-07-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAP"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.004575729370117}},"branch_attrs":{"mutations":{"nuc":["C5407A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF6: L61D"}}},{"name":"XAN","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAN"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.080811023712158}},"branch_attrs":{"mutations":{"nuc":["C7973A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C17822T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T27696C","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29666T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L2570M","L3201F"],"ORF1b":["P1452L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L2570M, L3201F; ORF1b: P1452L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAR","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAR"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.452944755554199}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21796T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"S":["R78S"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; S: R78S","spike_mutations":"R78S"}}},{"name":"XAQ","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAQ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","C9857T","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A23779T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XAS","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAS"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.454671859741211}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF8":["Q18*"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"ORF8: Q18*; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAT","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAT"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.875851154327393}},"branch_attrs":{"mutations":{"nuc":["C8991T","C9866T","C10277T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C19317T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25810T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["A2909V","L3201F","L3338F"],"ORF3a":["L140F"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: A2909V, L3201F, L3338F; ORF3a: L140F; ORF6: L61D"}}},{"name":"XAU","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAU"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.1733574867248535}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T17407C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A24433G","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F; ORF3a: H78Y"}}},{"name":"XAV","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAV"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.717791557312012}},"branch_attrs":{"mutations":{"nuc":["C6606T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C15960T","G17278T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T27438C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S2114F","L3201F"],"ORF1b":["V1271L"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: S2114F, L3201F; ORF1b: V1271L; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XAW","node_attrs":{"div":82,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAW"},"immune_escape":{"value":"0.274687314409391"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C335T","G569A","G670T","T689C","G1048T","G1125A","C1973T","T2790C","G3246A","G4181T","A4184G","T4321C","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9344C","G9424A","T9534C","T9676C","T10198C","A10323G","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","G11330A","A11332G","C11866T","T12880C","C13806T","C13994T","C14585T","G15451A","T15714C","C16466T","C17304T","T17410C","C17550T","A17973G","G18163A","G18525A","C19220T","C19290T","T19955C","G20055A","C20402T","G20493A","C21575T","T21618G","T21634A","T21635C","T21637C","T21638C","T21639C","T21641G","A21987G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22200T","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","T22674C","G22899A","T22942A","G23040A","T23042C","C23114T","G23599T","G24145A","A25592G","C26537T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G28562A","G28646A","C28849T","C28873T","A28881T","A28882G","C28883G","G28916T","G29402T","C29510A","C29635T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"N":["L13P","-31E","-32R","-33S","D63G","G97S","A125T","K203M","R204G","G215C","D377Y","R413S"],"ORF1a":["R24C","E102K","R135S","S142P","K261N","R287K","I842T","S994N","A1306S","S1307G","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","F3027L","I3090T","K3353R","H3395P","T3646A","-3675S","-3676G","-3677F","V3689M"],"ORF1b":["A176V","A373V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T","S2312L"],"ORF3a":["K67R"],"ORF8":["D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["L5F","I19R","-24L","-25L","-26P","S27A","D142G","E156-","F157-","R158G","N211-","L212I","G213V","L242-","A243-","F371S","G446D","N460K","R493Q","S494P","K679N"]},"labels":{"aa":"N: L13P, -31E, -32R, -33S, D63G, G97S, A125T, K203M, R204G, G215C, D377Y, R413S; ORF1a: R24C, E102K, R135S, S142P, K261N, R287K, I842T, S994N, A1306S, S1307G, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, F3027L, I3090T, K3353R, H3395P, T3646A, -3675S, -3676G, -3677F, V3689M; ORF1b: A176V, A373V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T, S2312L; ORF3a: K67R; ORF8: D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N","spike_mutations":"L5F, I19R, -24L, -25L, -26P, S27A, D142G, E156-, F157-, R158G, N211-, L212I, G213V, L242-, A243-, F371S, G446D, N460K, R493Q, S494P, K679N"}}},{"name":"XAZ","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAZ"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.731168270111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C2232T","C3317T","T3358C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["A656V","P1018S"],"ORF6":["L61D"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: A656V, P1018S; ORF6: L61D; S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}}},{"name":"XBA","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":4},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBA"},"immune_escape":{"value":"0.29808642936638835"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G4181T","A4184G","T4321C","C6402T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T10198C","A10447G","A10449C","A11201G","T11289C","T11291G","T11292G","A11332G","T12880C","G13812T","C14790T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","A22991G","G23040A","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","T27638C","A27663T","C27752T","T27807C","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"N":["-31E","-32R","-33S","D63G","D377Y","R413S"],"ORF1a":["A1306S","S1307G","P2046L","P2287S","T2777I","V2930L","F3027L","I3090T","H3395P","T3646A","-3675S","-3676G","-3677F"],"ORF1b":["M115I","A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["-27E","-28N","-29A","T60A"],"S":["L18F","I19R","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","N477D","R493Q","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; N: -31E, -32R, -33S, D63G, D377Y, R413S; ORF1a: A1306S, S1307G, P2046L, P2287S, T2777I, V2930L, F3027L, I3090T, H3395P, T3646A, -3675S, -3676G, -3677F; ORF1b: M115I, A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: -27E, -28N, -29A, T60A; S: L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I","clade":"Delta","spike_mutations":"L18F, I19R, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, N477D, R493Q, T1117I"}}},{"name":"XBD","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBD"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23019C","G23040A","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486S","R493Q","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486S, R493Q, A1020S"}}},{"name":"XBE","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBE"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.574315547943115}},"branch_attrs":{"mutations":{"nuc":["C1627T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","T22917G","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27800T","C27889T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"N":["E136D"],"ORF1b":["T1050N"],"ORF6":["L61D"],"S":["H69-","V70-","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1b: T1050N; ORF6: L61D; S: H69-, V70-, R346T, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, R346T, L452R, F486V, R493Q"}}},{"name":"XBH","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBH"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7528T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13730T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22786A","G22898A","T22942G","T23019C","G23040A","G25157A","C25416T","A26275G","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","T29734G","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757G","T29758C","T29759G"],"E":["T11A"],"N":["-31E","-32R","-33S"],"ORF1a":["L3201F"],"ORF1b":["A88V"],"ORF9b":["-27E","-28N","-29A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","S408R","G446S","N460K","F486S","R493Q","D1199N"]},"labels":{"aa":"E: T11A; N: -31E, -32R, -33S; ORF1a: L3201F; ORF1b: A88V; ORF9b: -27E, -28N, -29A; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, S408R, G446S, N460K, F486S, R493Q, D1199N"}}},{"name":"XBG","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBG"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C9866T","C10116T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11665T","A19812G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","A24676G","T26180C","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["L3201F","T3284I"],"ORF3a":["I263T"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: L3201F, T3284I; ORF3a: I263T; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q"}}},{"name":"XBN","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBN"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["A2863G","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A19459G","C19554T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","C25638T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P","I1998V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F; ORF1b: G662S, S959P, I1998V; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XBM","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBM"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19812G","G19891A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22304A","G22599C","T22917G","T23018G","G23040A","C23202T","G24620T","G26529A","T26858C","A27038G","C27259A","C27382G","T27383A","C27384T","C27549T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29868A"],"M":["D3N"],"ORF1a":["L3201F"],"ORF1b":["D2142N"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["Y248N","R346T","L452R","F486V","R493Q","T547I","A1020S"]},"labels":{"aa":"M: D3N; ORF1a: L3201F; ORF1b: D2142N; ORF6: L61D; ORF9b: D16G; S: Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S","spike_mutations":"Y248N, R346T, L452R, F486V, R493Q, T547I, A1020S"}}},{"name":"XBP","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBP"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G204A","C3796T","C3927T","C4586T","C5183T","C7303T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12952T","C13965T","C15277T","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","A22893C","T22917G","T22942A","T23018G","G23040A","T23773C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["H604Y","G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","I210V","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: H604Y, G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBR","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBR"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C3796T","C3927T","C4586T","C5183T","A5844G","C8597T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","G15451A","C21077T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","C22855T","A22893C","T22917G","T22942A","T23018G","G23040A","G25471C","C25553T","T25569C","G26031A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G392D","I567V","S1221L","P1640S","K1860R","L2778F","L3201F","N4060S"],"ORF1b":["G662S","T2537I"],"ORF3a":["D27H","A54V"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G392D, I567V, S1221L, P1640S, K1860R, L2778F, L3201F, N4060S; ORF1b: G662S, T2537I; ORF3a: D27H, A54V; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBS","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBS"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C2842T","C3796T","C3809T","C3927T","C4586T","C5183T","C6982T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T20748C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["G82-","H83-","V84-","M85V","L1182F","S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["K147E","W152R","F157L","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: G82-, H83-, V84-, M85V, L1182F, S1221L, P1640S, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: S10F; S: K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBT","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBT"},"immune_escape":{"value":"0.5037920175803539"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C829T","C1627T","A3207G","G4288A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","T22917G","T23018G","G23040A","G23587A","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["D981G","L3201F","N4060S"],"ORF1b":["G662S"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","L452R","F486V","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: D981G, L3201F, N4060S; ORF1b: G662S; ORF6: L61D; ORF9b: D16G; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, L452R, F486V, R493Q"}}},{"name":"XBQ","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBQ"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G14829T","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["M454I","G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: M454I, G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBU","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBU"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5192T","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22893C","T22917G","T22942A","T23018G","G23040A","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XBW","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBW"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22612C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C24130T","C25416T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","G29260A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XBV","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBV"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8040G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","G15957T","C16616A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C23123A","A23223G","A24170G","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["D2592G"],"ORF1b":["T1050N"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q","P521T","E554G","I870V"]},"labels":{"aa":"E: T11A; ORF1a: D2592G; ORF1b: T1050N; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q, P521T, E554G, I870V"}}},{"name":"XBY","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBY"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","C5812T","C9532T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G19962T","C21054T","G21305A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28137A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","R2613H"],"ORF8":["S82T"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, R2613H; ORF8: S82T; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCA","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCA"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2062T","C3796T","C3927T","C4586T","C5183T","C5192T","C5748A","T9454C","C9866T","C11124T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T13324C","G15451A","G18583A","C19017T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21893A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","C22747T","A22893C","T22917G","T22942A","T23018G","G23040A","C23595T","T25975C","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"M":["D3N"],"N":["E136D"],"ORF1a":["S1221L","P1640S","T1828N","L3201F","A3620V","N4060S"],"ORF1b":["G662S","V1706I"],"ORF3a":["S195P"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["D111N","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K444T","L452R","N460K","F486V","R493Q","T678I"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: S1221L, P1640S, T1828N, L3201F, A3620V, N4060S; ORF1b: G662S, V1706I; ORF3a: S195P; ORF6: L61D; ORF9b: S10F; S: D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I","spike_mutations":"D111N, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K444T, L452R, N460K, F486V, R493Q, T678I"}}},{"name":"XBZ","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBZ"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C1627T","T2954C","C6040T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","T14257C","G16935A","A17039G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22599C","C22858T","A22893C","T22917G","T22942A","T23018G","G23040A","C23086T","G26428T","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","C28770T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["V62F"],"M":["D3N"],"N":["E136D","T166I"],"ORF1a":["L3829F"],"ORF1b":["Y264H","M1156I","N1191S"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","Y144-","R346T","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"E: V62F; M: D3N; N: E136D, T166I; ORF1a: L3829F; ORF1b: Y264H, M1156I, N1191S; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, Y144-, R346T, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCB","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-04-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCB"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1627T","A11126G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C14724T","G18651A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22302-","T22303-","T22304-","T22348A","T22813G","A22893C","T22917G","T22942A","T23018G","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27600T","C27889T","T28282C","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D"],"ORF1a":["M3621V","A4016T"],"ORF6":["L61D"],"ORF9b":["S10F"],"S":["H69-","V70-","S247-","Y248N","N417K","K444T","L452R","N460K","F486V","R493Q"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: M3621V, A4016T; ORF6: L61D; ORF9b: S10F; S: H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q","spike_mutations":"H69-, V70-, S247-, Y248N, N417K, K444T, L452R, N460K, F486V, R493Q"}}},{"name":"XCD","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCD"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","T18006C","A19173G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22203A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G28077T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","G28681T","C29367T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"N":["E136D","P365L"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","R214H","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478I","F486P","F490S","R493Q"]},"labels":{"aa":"M: D3N; N: E136D, P365L; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF6: L61D; ORF8: V62L; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, R214H, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478I, F486P, F490S, R493Q"}}},{"name":"XCC","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCC"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["C1545T","C3796T","C3857A","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A427V","Q1198K","S1221L","P1640S","L3201F","N4060S","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: A427V, Q1198K, S1221L, P1640S, L3201F, N4060S, T4175I; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCE","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCE"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C1931A","T2954C","G9424A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15810T","T15939C","T16342C","T17859C","G18811A","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["Q556K","L3201F"],"ORF1b":["G662S","S959P","D1782N"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","Y200C","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: Q556K, L3201F; ORF1b: G662S, S959P, D1782N; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, Y200C, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XCG","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCG"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C1627T","A8170G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","T22813G","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"S":["V83A","Y144-","Q183E","G213E","G252V","D339H","R346T","L368I","N417K","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: L3201F; ORF1b: G662S, S959P; ORF8: G8*; S: V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q","spike_mutations":"V83A, Y144-, Q183E, G213E, G252V, D339H, R346T, L368I, N417K, V445P, G446S, N460K, F486S, F490S, R493Q"}}},{"name":"XCJ","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCJ"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C1063T","C6312T","A6616G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","G22200A","A22320G","G22577C","G22599C","C22664A","T22843C","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27431T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28770T","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["T166I"],"ORF1a":["K47R","T2016I","L3201F"],"ORF1b":["G662S"],"ORF7a":["A13V"],"S":["V83A","Y144-","H146Q","G181R","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; N: T166I; ORF1a: K47R, T2016I, L3201F; ORF1b: G662S; ORF7a: A13V; S: V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, G181R, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XCM","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCM"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G331T","A405G","C4234T","C5730T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T13560C","G15451A","C15738T","T15939C","T17661C","T17859C","A18879G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","G22331A","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","C24134A","A24373G","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A29558G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["Q22H","K47R","T1822I","G2091S","L3201F"],"ORF1b":["G662S"],"ORF3a":["A72T","A110V"],"S":["V83A","Y144-","H146Q","F157L","N185D","I210V","G257S","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: Q22H, K47R, T1822I, G2091S, L3201F; ORF1b: G662S; ORF3a: A72T, A110V; S: V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"V83A, Y144-, H146Q, F157L, N185D, I210V, G257S, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}}},{"name":"XCN","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCN"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C337T","C1142T","C1471T","C1513T","C1686T","T2372C","C3796T","C3927T","C4586T","C5183T","C7318T","C8782T","G8849A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C14790T","T14961C","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21807A","C21910T","A22001G","T22016C","C22033A","A22121G","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T23332C","C23453T","C25416T","C25572T","A26275G","A27507C","C27635T","G27915T","C28253T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["L293F","A474V","S1221L","P1640S","V2862M","L3201F","N4060S"],"ORF1b":["G662S"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["P82H","K147E","W152R","F157L","K187E","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","P631S"]},"labels":{"aa":"E: T11A; ORF1a: L293F, A474V, S1221L, P1640S, V2862M, L3201F, N4060S; ORF1b: G662S; ORF7a: S81L; ORF8: G8*; ORF9b: I5T; S: P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S","spike_mutations":"P82H, K147E, W152R, F157L, K187E, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, P631S"}}},{"name":"XCL","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCL"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A405G","C7417T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","C15755G","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","G23093A","C23741T","A25045G","C25046T","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S763C","S959P"],"ORF8":["G8*","P38S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","V511I","P1162S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S763C, S959P; ORF8: G8*, P38S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, V511I, P1162S"}}},{"name":"XCK","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCK"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T2128C","G3242A","C5512T","G5720A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12970T","G15451A","C15738T","T15939C","T16342C","T17859C","T18096C","A19326G","G19962T","G20060T","A21137G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C23664T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G26529A","T26858C","G26951C","C27259A","C27382G","T27383A","C27384T","C27889T","C28163A","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28681T","T29726-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"M":["D3N"],"N":["E136D"],"ORF1a":["K47R","G993S","G1819S","L3201F","T4175I"],"ORF1b":["G662S","S959P","S2198I","K2557R"],"ORF3a":["V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","A701V"]},"labels":{"aa":"M: D3N; N: E136D; ORF1a: K47R, G993S, G1819S, L3201F, T4175I; ORF1b: G662S, S959P, S2198I, K2557R; ORF3a: V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, A701V"}}},{"name":"XCS","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCS"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","G15451A","C15738T","T15939C","T16342C","C17010T","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","T24424A","C25416T","A26275G","A27669G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","A29221G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L","H954Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L, H954Q"}}},{"name":"XCR","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCR"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A405G","C1973T","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C13405T","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A24373C","A25359G","C25416T","A26275G","A26708G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F","A4068S"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L","K1266R"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, A4068S; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L, K1266R"}}},{"name":"XCP","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCP"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C3622T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","A14634G","G15451A","C15738T","T15939C","T16342C","T17124C","T17859C","C19185T","A19326G","C19488T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","I3758V","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","A65V"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, I3758V, T4175I; ORF1b: G662S, S959P; ORF8: G8*, A65V; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCQ","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCQ"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","G6536A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A13187G","G15451A","C15738T","T15939C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","A22320G","C22388T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C23757T","C25416T","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F","I4308V"],"ORF1b":["G662S"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S","T732I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F, I4308V; ORF1b: G662S; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S, T732I"}}},{"name":"XCU","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCU"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C1437T","T3478C","A4184G","T4321C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","T9344C","G9424A","T9534C","C9891T","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","A17207G","T17410C","G18163A","A19890G","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","T23042C","C23123A","C25416T","A26275G","C26606T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28376A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["A35T"],"ORF1a":["S391F","S1307G","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","F3027L","I3090T","A3209V","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","Y1247C","C1315R","V1566I","I2163T"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","S494P","P521T"]},"labels":{"aa":"E: T11A; N: A35T; ORF1a: S391F, S1307G, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, F3027L, I3090T, A3209V, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, Y1247C, C1315R, V1566I, I2163T; ORF8: G8*; ORF9b: I5T; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, S494P, P521T"}}},{"name":"XCV","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCV"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","T5422C","C7044A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27065A","G27915T","A28182G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","P2260H","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, P2260H, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, S97G; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XCY","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCY"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","T23018C","T23019C","T23031C","G23040A","A25045G","C25416T","A26275G","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF8":["G8*","P38S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF8: G8*, P38S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, F486P, F490S, R493Q"}}},{"name":"XCZ","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCZ"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","A15436G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","T22609G","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23280T","C23673T","A25045G","C25416T","C25658T","A26275G","C26735T","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28519T","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","M657V","G662S","S959P"],"ORF3a":["T89I"],"ORF8":["G8*","P38S"],"ORF9b":["T79I"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","T573I","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, M657V, G662S, S959P; ORF3a: T89I; ORF8: G8*, P38S; ORF9b: T79I; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, T573I, S704L"}}},{"name":"XCW","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCW"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C4234T","T6394C","G6536A","G8863T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T14305C","G15451A","C15738T","T15939C","T17859C","G18636A","T18882C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","G22200A","A22320G","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C23123T","C25416T","A26275G","C27513T","C27684T","G27915T","T28034C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","G2091S","L3201F"],"ORF1b":["Y280H","G662S"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["V83A","Y144-","H146Q","Q183E","I210-","G213E","D253G","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q","P521S"]},"labels":{"aa":"E: T11A; ORF1a: K47R, G2091S, L3201F; ORF1b: Y280H, G662S; ORF8: G8*; ORF9b: I5T, N55S; S: V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S","spike_mutations":"V83A, Y144-, H146Q, Q183E, I210-, G213E, D253G, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q, P521S"}}},{"name":"XDB","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDB"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A14856G","G15451A","C15738T","T15939C","G15982A","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","V839I","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","E180V","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","K478R","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, V839I, S959P, D1746Y; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, E180V, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, K478R, F486P, F490S, R493Q"}}},{"name":"XDC","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDC"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C2110T","C2334T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","C15763T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","C21036T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","A28447G","C29386T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T","N55S"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*; ORF9b: I5T, N55S; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDE","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDE"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21363C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","C25416T","A26275G","A26612G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29535T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDF","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDF"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C335T","A405G","T3453C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","C22570T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","A27507C","G27666T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T28382C","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["S37P"],"ORF1a":["R24C","K47R","V1063A","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: S37P; ORF1a: R24C, K47R, V1063A, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF7a: E91D; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDH","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDH"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2992A","C3796T","C3927T","C4586T","T4744C","C5183T","T7477C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C13335T","G15451A","C20235T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A21987G","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","A22629C","C22664A","G22895C","T22896C","G22898A","G22927A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["D909E","S1221L","P1640S","L3201F","N4060S","A4357V"],"ORF1b":["G662S"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["D142G","K147E","W152R","F157L","I210V","G257S","D339H","R346T","K356T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: D909E, S1221L, P1640S, L3201F, N4060S, A4357V; ORF1b: G662S; ORF8: G8*; ORF9b: I5T; S: D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"D142G, K147E, W152R, F157L, I210V, G257S, D339H, R346T, K356T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}}},{"name":"XDG","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDG"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C547T","C1758T","T4579A","T4690C","T4930C","G5720A","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T16905C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","A23598G","C25416T","A25744G","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28754T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["L161F"],"ORF1a":["K47R","A498V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P"],"ORF3a":["I118V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q","K679R"]},"labels":{"aa":"E: T11A; N: L161F; ORF1a: K47R, A498V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P; ORF3a: I118V; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q, K679R"}}},{"name":"XDJ","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDJ"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["A405G","C8947T","C9866T","A10861G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","A14856G","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","C25572T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29081T","C29625T","A29700G","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"N":["V270L"],"ORF1a":["K47R","L3201F","L3829F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","F157L","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; N: V270L; ORF1a: K47R, L3201F, L3829F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"Q52H, V83A, Y144-, H146Q, F157L, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q"}}},{"name":"XDL","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDL"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","C2650T","G5720A","C6541T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G13627A","G15451A","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","T17859C","C17976T","A18492G","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21718T","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","C22480T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","T23018C","T23019C","T23031C","G23040A","T24903C","C25416T","C25572T","A26275G","A27507C","G27915T","C28253A","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["D54N","G662S","S959P"],"ORF8":["G8*","F120L"],"ORF9b":["I5T"],"S":["Q52H","V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","I1114T"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: D54N, G662S, S959P; ORF8: G8*, F120L; ORF9b: I5T; S: Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T","spike_mutations":"Q52H, V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, I1114T"}}},{"name":"XDM","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDM"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","A22995T","T23018C","T23019C","T23031C","G23040A","G23222A","C24034T","T24046C","C25416T","A26275G","C27059T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","A475V","K478I","F486P","F490S","R493Q","E554K"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, A475V, K478I, F486P, F490S, R493Q, E554K"}}},{"name":"XDN","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDN"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C280T","C897A","C1762A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","T13339C","C14425T","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C25416T","A26275G","G27915T","C28087T","T28282C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","F499L","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*","A65V"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F"]},"labels":{"aa":"E: T11A; ORF1a: A211D, F499L, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*, A65V; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F"}}},{"name":"XDS","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDS"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDS"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A405G","G598A","C1889T","C2334T","G5720A","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29409T","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","C29836T"],"M":["D3H","T30A","A104V"],"N":["T379I"],"ORF1a":["K47R","R542C","A690V","G1819S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: T379I; ORF1a: K47R, R542C, A690V, G1819S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDT","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDT"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","C1601T","G3431T","T4321C","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9661T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","T13339C","T15756A","A18492G","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","A25045G","C25416T","T25496C","C25658T","A26275G","G27014A","C27059T","G27915T","C28005T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G","G29778A"],"E":["T11A"],"ORF1a":["A211D","L446F","V1056L","N2526S","A2710T","I2790V","V3593F","V3892A","T4175I"],"ORF3a":["I35T","T89I"],"ORF8":["G8*","P38S"],"S":["R21T","H69-","V70-","V127F","Y144-","R158G","N211-","L212I","L216F","A222V","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, L446F, V1056L, N2526S, A2710T, I2790V, V3593F, V3892A, T4175I; ORF3a: I35T, T89I; ORF8: G8*, P38S; S: R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, H69-, V70-, V127F, Y144-, R158G, N211-, L212I, L216F, A222V, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}}},{"name":"XDU","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDU"},"immune_escape":{"value":"0.9475349114594978"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C3177T","C3587T","C3944A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22775G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C26078T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","P971L","H1108Y","Q1227K","L3201F","L3829F","T4175I"],"ORF3a":["T229I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","N405D","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, P971L, H1108Y, Q1227K, L3201F, L3829F, T4175I; ORF3a: T229I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, N405D, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDW","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDW"},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","T1030C","A2127G","G3431T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","C14120T","T15756A","A18492G","C21301T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","Y621C","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF1b":["P218L","P2612S"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A263V","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","A701V"]},"labels":{"aa":"E: T11A; ORF1a: A211D, Y621C, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF1b: P218L, P2612S; ORF8: G8*; ORF9b: I5T, S63F; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A263V, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, A701V"}}},{"name":"XE","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":48},"designation_date":{"value":"2022-03-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XE"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C14599T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T"}}},{"name":"XEA","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEA"},"immune_escape":{"value":"1.2268340125514634"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C13255T","T13339C","A13712G","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","V1056L","D1513E","K1973R","N2526S","A2529S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["K82R"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","A484E","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, V1056L, D1513E, K1973R, N2526S, A2529S, A2710T, V3593F, R3821K, T4175I; ORF1b: K82R; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, A484E, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XDY","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDY"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","G19669A","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","C22858T","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF1b":["G2068R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF1b: G2068R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XDZ","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDZ"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A405G","C1889T","C2334T","G5720A","C7086T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","C23557T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","R542C","A690V","G1819S","T2274I","A3143V","L3201F","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, R542C, A690V, G1819S, T2274I, A3143V, L3201F, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XEB","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEB"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEB"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A405G","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XED","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XED"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":17.361},"partiallyAliased":{"value":"XED"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","C9430T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","A13308G","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","C25350T","G26529C","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","A104V"],"N":["Q229K"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I","K4348R"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L","P1263L"]},"labels":{"aa":"M: D3H, A104V; N: Q229K; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I, K4348R; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L, P1263L"}}},{"name":"XEE","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEE"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XEE"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.853520393371582}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","T3565C","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","G17334T","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","K1973R","T2121A","T2283I","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","H146Q","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, K1973R, T2121A, T2283I, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, H146Q, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XEG","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":950.694},"partiallyAliased":{"value":"XEG"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C897A","A2443G","C2939T","C3876T","C4234T","G6536A","A6646G","T6747C","C7819G","C9866T","T10723C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A17637G","A18492G","G19327T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","C23191T","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G29706T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["A211D","P892S","A1204V","G2091S","L2161S","L3201F","T4175I"],"ORF1b":["A1954S"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","F456V","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: A211D, P892S, A1204V, G2091S, L2161S, L3201F, T4175I; ORF1b: A1954S; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, F456V, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}}},{"name":"XG","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":9},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XG"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XG"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","A4184G","T4321C","T5386G","C5672T","G5924A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A19855G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","P1803S","V1887I","L3201F"],"ORF1b":["I2130V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, P1803S, V1887I, L3201F; ORF1b: I2130V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XEF","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":34.028},"partiallyAliased":{"value":"XEF"},"immune_escape":{"value":"1.7268345560655398"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","T3565C","G4255T","C4683T","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22599C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","A1473V","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S31-","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","Q183H","N211-","L212I","L216F","H245N","A264D","I332V","L335S","D339H","R346T","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, A1473V, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, S31-, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, Q183H, N211-, L212I, L216F, H245N, A264D, I332V, L335S, D339H, R346T, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}}},{"name":"XH","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XH"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.368658065795898}},"branch_attrs":{"mutations":{"nuc":["G670T","T902C","C904A","G1244A","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","C25624T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28435T","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","C213R","G327S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T"],"ORF3a":["H78Y"],"ORF9b":["P51L"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, C213R, G327S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T; ORF3a: H78Y; ORF9b: P51L; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XJ","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XJ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","G11287-","T11288-","T11289-","T11291G","T11292G","A11537G","T12880C","T13195C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","C27945T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3675F","-3676G","-3677F","I3758V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3675F, -3676G, -3677F, I3758V; ORF8: Q18*"}}},{"name":"XK","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":45},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XK"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","A16064G","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G22200T","C22792T","G23055A","T23063A","C23075T","A23767G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","R1628C","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["Q866R","C1315R"],"S":["G213V","R498Q","Y501N","H505Y"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, R1628C, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: Q866R, C1315R; S: G213V, R498Q, Y501N, H505Y","spike_mutations":"G213V, R498Q, Y501N, H505Y"}}},{"name":"XM","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":46},"designation_date":{"value":"2022-03-31"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XM"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XM"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.152749061584473}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G26577C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["E19Q"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R"]},"labels":{"aa":"M: E19Q; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R"}}},{"name":"XL","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XL"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G670T","C875T","T2790C","A2832G","C3241T","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G14229A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","L204F","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, L204F, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XP","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XP"},"immune_escape":{"value":"0.3616394203564539"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"placement_prior":{"value":-3.0006814002990723}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","C15240T","T15714C","T17410C","T19955C","G20055A","T21618C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22599A","T22673C","G22688A","A22775G","C22786A","G22898A","G23048A","C23202A","C24130A","A24190C","C24503T","T26060C","A26530G","T26858C","C26880A","C27382G","T27383A","C27384T","A28254-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3G","L120I"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"ORF1b":["C1315R","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF8":["I121-"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","R346K","F371L","A376T","N405D","S408R","G446S","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G, L120I; ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; ORF1b: C1315R, I2163T; ORF3a: I223T; ORF6: L61D; ORF8: I121-; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, R346K, F371L, A376T, N405D, S408R, G446S, G496S, T547K, N856K, L981F"}}},{"name":"XN","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XN"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XN"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.342913627624512}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C9866T","G10986A","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","L3201F","R3574K"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, L3201F, R3574K"}}},{"name":"XQ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XQ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.5721659660339355}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A17615G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","L3201F"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, L3201F; ORF1b: K1383R"}}},{"name":"XR","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XR"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","C2470T","T2790C","A2832G","A4184G","T4321C","C4893T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G13295A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A25524G","C27131T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","T1543I","L3201F","D4344N"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, T1543I, L3201F, D4344N"}}},{"name":"XT","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XT"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.091723442077637}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C13994T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","G21786T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1b":["A176V"],"ORF6":["L61D"],"S":["G75V"]},"labels":{"aa":"M: D3G; N: R413S; ORF1b: A176V; ORF6: L61D; S: G75V","spike_mutations":"G75V"}}},{"name":"XV","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":10},"totalAminoacidSubstitutions":{"value":47},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XV"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.536415100097656}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","C3583T","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","T12880C","T13195C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C22792T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","L3674-","-3677F","I3758V"],"S":["-24L","-25P","-26P","S27A"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, L3674-, -3677F, I3758V; S: -24L, -25P, -26P, S27A","spike_mutations":"-24L, -25P, -26P, S27A"}}},{"name":"XU","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XU"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XU"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["G670T","T2790C","A2832G","A4184G","T4321C","T5386G","G5924A","G6513-","T6514-","T6515-","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C16887T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C25416T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","V1887I","S2083-","L2084I","L3201F"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, V1887I, S2083-, L2084I, L3201F"}}},{"name":"XW","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-05-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XW"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XW"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G670T","C2470T","T2790C","A2832G","C10507T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12756T","G16020T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","T4164I"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, T4164I"}}},{"name":"XZ","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XZ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XZ"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.090399742126465}},"branch_attrs":{"mutations":{"nuc":["C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G20398A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C22792T","A26530G","T26858C","C27382G","T27383A","C27384T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29742G","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"M":["D3G"],"N":["R413S"],"ORF1a":["L3201F"],"ORF1b":["E2311K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3G; N: R413S; ORF1a: L3201F; ORF1b: E2311K; ORF6: L61D"}}},{"name":"XY","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XY"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","G670T","A1585G","C2470T","T2790C","A2832G","A4184G","T4321C","T5386G","G6513-","T6514-","T6515-","G8393A","T9344C","G9424A","T9534C","T10198C","A10447G","T11049C","T11285-","T11286-","G11287-","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","A11537G","C12085T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22351G","C22792T","C26058T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"ORF1a":["R135S","I842T","K856R","S1307G","S2083-","L2084I","A2710T","F3027L","I3090T","V3595A","L3674-","-3677F","I3758V"]},"labels":{"aa":"ORF1a: R135S, I842T, K856R, S1307G, S2083-, L2084I, A2710T, F3027L, I3090T, V3595A, L3674-, -3677F, I3758V"}}},{"name":"internal_XBK","node_attrs":{"div":25,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C1627T","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["S1221L","P1640S","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBK.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBK.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBK.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBK"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":43,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A405G","A1124G","C1973T","A2163C","C7564T","T8737C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12467T","G15451A","C15738T","T15939C","T16342C","A16856G","T17124C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22624T","C22664A","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C23673T","C25416T","G25947C","A26275G","C27741T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28657T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","R287G","E633A","L3201F","A4068S"],"ORF1b":["G662S","S959P","D1130G"],"ORF3a":["Q185H"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","L455F","F456L","N460K","F486P","F490S","R493Q","S704L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R287G, E633A, L3201F, A4068S; ORF1b: G662S, S959P, D1130G; ORF3a: Q185H; ORF8: G8*; ORF9b: I5T; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, L455F, F456L, N460K, F486P, F490S, R493Q, S704L"}},"children":[{"name":"XCH.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCH.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCH.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCH"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":45,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["A405G","C1684T","C1889T","C2334T","G5720A","C7051T","C9693T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","G15451A","C15738T","T15939C","T16342C","A16878T","T17859C","A18492G","A19886G","C20320T","A20741G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22115G","A22190G","G22577C","G22599C","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","T23019C","G23040A","T24073C","C24134A","T24991A","C25416T","G25606A","C25721T","T25959C","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734G","T29735A","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758A","T29759G"],"E":["T11A"],"ORF1a":["K47R","R542C","A690V","G1819S","A3143V","L3201F","T4175I"],"ORF1b":["G662S","S959P","K2140R","H2285Y","Q2425R"],"ORF3a":["A72T","A110V"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["K147E","W152R","F157L","N185D","I210V","D339H","R346T","K444T","G446S","L452R","L455F","F456L","N460K","F486S","R493Q","L858I"]},"labels":{"aa":"E: T11A; ORF1a: K47R, R542C, A690V, G1819S, A3143V, L3201F, T4175I; ORF1b: G662S, S959P, K2140R, H2285Y, Q2425R; ORF3a: A72T, A110V; ORF8: G8*; ORF9b: I5T; S: K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I","spike_mutations":"K147E, W152R, F157L, N185D, I210V, D339H, R346T, K444T, G446S, L452R, L455F, F456L, N460K, F486S, R493Q, L858I"}},"children":[{"name":"XCT.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCT.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCT"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":44,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","A1269G","T8908C","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","A13693G","A14856G","G15451A","C15738T","T15939C","T16342C","T17859C","G18703T","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","A22995G","T23018C","T23019C","T23031C","G23040A","G23222A","C23664T","C25416T","A26275G","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28471T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","D335G","L3201F","L3829F"],"ORF1b":["T76A","G662S","S959P","D1746Y"],"ORF8":["G8*"],"ORF9b":["I5T","S63F"],"S":["V83A","Y144-","H146Q","E180V","K182Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","K478R","F486P","F490S","R493Q","E554K","A701V"]},"labels":{"aa":"E: T11A; ORF1a: K47R, D335G, L3201F, L3829F; ORF1b: T76A, G662S, S959P, D1746Y; ORF8: G8*; ORF9b: I5T, S63F; S: V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V","spike_mutations":"V83A, Y144-, H146Q, E180V, K182Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, K478R, F486P, F490S, R493Q, E554K, A701V"}},"children":[{"name":"XDA.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDA.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDA.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDA"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":67,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18657T","C18894T","C19716T","C21622T","G21624C","C21627A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","C23039G","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","G24872T","C24990T","C25006T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","C28291A","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","G28884C","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["R204P","Q229K"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"ORF9b":["P3H"],"S":["R21T","T22N","S50L","F59S","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","N481K","V483-","A484K","F486P","R493E","E554K","A570V","P621S","H681R","S939F","V1104L","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: R204P, Q229K; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; ORF9b: P3H; S: R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L","spike_mutations":"R21T, T22N, S50L, F59S, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, N481K, V483-, A484K, F486P, R493E, E554K, A570V, P621S, H681R, S939F, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEC.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":29.34},"partiallyAliased":{"value":"XEC.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":34.028},"partiallyAliased":{"value":"XEC"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":31,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A405G","G4006A","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17067C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22928C","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","T26012G","A26275G","G27915T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"ORF3a":["F207C"],"ORF8":["G8*"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","F456L","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; ORF3a: F207C; ORF8: G8*; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, F456L, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XCF","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":31,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":32,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XCF.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XCF.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C774T","C897A","G3431T","T3565C","A6183G","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","T18453C","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["T170I","A211D","V1056L","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: T170I, A211D, V1056L, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDP.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDP.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A405G","C2668T","C6896T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","L3201F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, L3201F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"XDR.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}},{"name":"XDR.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDR.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBL","node_attrs":{"div":34,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["A405G","G3446A","C3796T","C3927T","C4586T","C5183T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","A20379G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22317T","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","G27915T","C28312T","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A1061T","S1221L","P1640S","L3201F"],"ORF1b":["G662S","S959P"],"ORF8":["G8*"],"ORF9b":["S10F"],"S":["V83A","Y144-","H146Q","Q183E","G213E","G252V","D339H","R346T","L368I","V445P","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A1061T, S1221L, P1640S, L3201F; ORF1b: G662S, S959P; ORF8: G8*; ORF9b: S10F; S: V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, G252V, D339H, R346T, L368I, V445P, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBL","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":34,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBL.3.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBL.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.0838518142700195}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C897A","G3431T","A6183G","C7420T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","T13339C","T15756A","A18492G","C21622T","G21624C","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C25416T","A26275G","G27915T","A27980G","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28846T","T29023C","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["A211D","V1056L","K1973R","N2526S","A2710T","V3593F","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","-24L","-25P","-26P","S27A","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","A484K","F486P","R493Q","E554K","A570V","P621S","H681R"]},"labels":{"aa":"E: T11A; ORF1a: A211D, V1056L, K1973R, N2526S, A2710T, V3593F, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R","spike_mutations":"R21T, -24L, -25P, -26P, S27A, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, A484K, F486P, R493Q, E554K, A570V, P621S, H681R"}},"children":[{"name":"XDQ","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.0838518142700195}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":54,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.49430513381958}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.2"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-04-18"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.1974196434021}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":55,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.1.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDQ.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDQ.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.2972259521484375}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C1471T","C2445T","G3072A","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9866T","C10189T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C17678T","C18252T","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C25896T","G26529A","T26858C","C27012T","C27259A","C27382G","T27383A","C27384T","C27513T","C27889T","A28330G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3N"],"ORF1a":["T727I","C936Y","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3201F","Q3922R"],"ORF1b":["T1404M"],"ORF6":["L61D"],"ORF9b":["D16G"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"M: D3N; ORF1a: T727I, C936Y, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3201F, Q3922R; ORF1b: T1404M; ORF6: L61D; ORF9b: D16G; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"XBJ","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"internal_XBJ_root","node_attrs":{"div":36,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.2"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.3"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.4"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":37,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.1.1"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBJ.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":55,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["A405G","C2334T","G5720A","C6541T","A7842G","C8293T","G8393A","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","A26275G","A27507C","G27915T","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C29625T","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K47R","A690V","G1819S","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF8":["G8*"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"E: T11A; ORF1a: K47R, A690V, G1819S, N2526S, A2710T, V3593F, R3821K, T4175I; ORF8: G8*; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":56,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.2","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"XDD.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"NODE_0000025","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDD.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDD.1.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{"nuc":["A405G","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","G11042T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","T13339C","T15756A","A18492G","C18894T","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23277T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","C28958A","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["K47R","K1973R","N2526S","A2710T","V3593F","R3821K","T4175I"],"ORF7b":["F19L"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","T572I","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: K47R, K1973R, N2526S, A2710T, V3593F, R3821K, T4175I; ORF7b: F19L; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, T572I, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.734684944152832}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDK.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","A23598G","C27297T"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"NODE_0000029","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.5"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.631465435028076}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}}]},{"name":"internal_0964eaa1","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XDK.4.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.4.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.4.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T","T22928C"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"],"S":["F456L"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_C29762T","node_attrs":{"div":59,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","T22928C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","F456L","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, F456L, Q1201K","spike_mutations":"R237K, F456L, Q1201K"}}},{"name":"NODE_0000032","node_attrs":{"div":61,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G11596A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"internal_0d74e965","node_attrs":{"div":62,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["C18664T"]}},"children":[{"name":"XDK.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDK.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDK.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["G22200A","T22928C"],"S":["G213E","F456L"]},"labels":{"aa":"S: G213E, F456L","spike_mutations":"G213E, F456L"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":24,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{"nuc":["G625T","C1627T","T3339C","C6070T","C8692T","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","A12444G","G15451A","G18583A","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22599C","G22898A","T22942G","T23018C","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"E":["T11A"],"ORF1a":["K120N","V1025A","L3201F","N4060S"],"ORF1b":["G662S","V1706I"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","R346T","G446S","N460K","F486P","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K120N, V1025A, L3201F, N4060S; ORF1b: G662S, V1706I; S: K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, R346T, G446S, N460K, F486P, F490S, R493Q"}},"children":[{"name":"XBF","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000035","node_attrs":{"div":24,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.680553913116455}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.10"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.10"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.3"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.4"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.5"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.6"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.9","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.9"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.9"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000036","node_attrs":{"div":25,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-08"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000037","node_attrs":{"div":27,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.7"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.005672931671143}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.7.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.7.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000038","node_attrs":{"div":26,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.8"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBF.8.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBF.8.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","T9344C","G9424A","T9534C","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C15026T","G15451A","T15714C","C16466T","T17410C","G18163A","C19220T","T19955C","G20055A","C21614T","T21618G","A21623G","T21634A","T21635C","T21636C","T21637C","T21638C","T21639C","T21641G","C21846T","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","G22899A","C22916A","T22917G","T23018C","T23019C","G23040A","C23423T","C23679T","C24912T","T25000C","C25413T","C25469T","T25584C","T26060C","T26270C","G26577C","C26681T","A26709G","T26767C","T26858C","G26959A","C27259A","C27382G","T27383A","C27384T","C27575G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-","G29779T"],"E":["I9T"],"M":["E19Q","T63A","I82T","R146H"],"ORF1a":["P2287S","T2777I","V2930L","F3027L","I3090T","T4161I"],"ORF1b":["A520V","G662S","P1000L","C1315R","V1566I","A1918V","I2163T"],"ORF3a":["S26L","I223T"],"ORF6":["L61D"],"ORF7a":["T61S"],"S":["L18F","I19R","R21G","-24L","-25P","-26P","S27A","T95I","W152L","E156-","F157-","R158G","F186L","G446D","L452R","F486P","R493Q","P621S","A706V","T1117I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T, R146H; ORF1a: P2287S, T2777I, V2930L, F3027L, I3090T, T4161I; ORF1b: A520V, G662S, P1000L, C1315R, V1566I, A1918V, I2163T; ORF3a: S26L, I223T; ORF6: L61D; ORF7a: T61S; S: L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I","spike_mutations":"L18F, I19R, R21G, -24L, -25P, -26P, S27A, T95I, W152L, E156-, F157-, R158G, F186L, G446D, L452R, F486P, R493Q, P621S, A706V, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-08-25"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000040","node_attrs":{"div":53,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000041","node_attrs":{"div":56,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.967257499694824}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000042","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.997220516204834}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000043","node_attrs":{"div":58,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15064811706543}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.794395446777344}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.2.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.2.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-4.697917461395264}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000044","node_attrs":{"div":60,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-5.5121307373046875}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000045","node_attrs":{"div":62,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-5.390020847320557}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"XAY.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000046","node_attrs":{"div":63,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-5.0932698249816895}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000047","node_attrs":{"div":64,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-4.776752948760986}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-6.127554416656494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000048","node_attrs":{"div":65,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.682618141174316}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"immune_escape":{"value":"0.752889267417711"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"placement_prior":{"value":-4.494446754455566}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GL.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"placement_prior":{"value":-7.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":57,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","A405G","C541T","C1170T","C6501A","C7113T","C9866T","A10042G","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12924T","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","C21622T","G21624C","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","T27810C","T28297C","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759-"],"M":["D3H","T30A","A104V"],"ORF1a":["K47R","S302F","P2079Q","T2283I","L3201F","P4220L"],"ORF1b":["G662S","S959P"],"ORF7b":["F19L"],"ORF9b":["I5T"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","L455S","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; ORF1a: K47R, S302F, P2079Q, T2283I, L3201F, P4220L; ORF1b: G662S, S959P; ORF7b: F19L; ORF9b: I5T; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, L455S, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000050","node_attrs":{"div":59,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"XDV.1.10"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.11"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.4","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.5","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.5"},"immune_escape":{"value":"1.5359962252743784"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.14808999999999992"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.8","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000051","node_attrs":{"div":62,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":6.25},"partiallyAliased":{"value":"XDV.1.2.1"},"immune_escape":{"value":"1.8051577060608006"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.26874999999999993"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}}]},{"name":"NODE_0000052","node_attrs":{"div":61,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.7"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"XDV.1.7.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000053","node_attrs":{"div":60,"clade_membership":{"value":"24D"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-17"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24D"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XDV.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XDV.1.9.1"},"immune_escape":{"value":"1.5422010449483097"},"clade_display":{"value":"24D (XDV.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24D"},"ace2_binding":{"value":"0.20783000000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":68,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4184G","T4321C","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","T9344C","G9424A","T9534C","C9891T","T10029C","T10198C","A10447G","A10449C","T11289C","T11291G","T11292G","T11418C","C11514T","T12880C","C13019T","T15030C","C15237T","G15451A","T15714C","C16466T","C16616T","T17410C","G18163A","T19955C","G20055A","T21634A","T21636C","T21637C","T21638C","T21639C","T21641G","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22200T","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","A22578G","G22898A","T23018C","T23019C","G23040A","A23670T","T25584C","C25854T","T26060C","T26270C","G26577C","A26709G","T26767C","T26819C","T26858C","C27259A","C27382G","T27383A","C27384T","T27718C","C27752T","T27807C","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","T28270-","T28311C","T28362G","T28363A","T28364G","T28365A","T28366A","T28367C","T28368G","T28369C","T28370A","A28461G","A28881T","A28882G","C28883G","G29402T","C29510A","T29734G","T29735A","T29736G","T29737G","T29738C","T29739C","T29740A","T29741C","T29743C","T29744G","T29745G","T29746A","T29747G","T29749A","T29750C","T29751G","T29752A","T29754C","T29755G","T29756A","T29757G","T29759G"],"E":["I9T"],"M":["E19Q","T63A","I82T"],"N":["L13P","-31E","-32R","-33S","D63G","K203M","R204G","D377Y","R413S"],"ORF1a":["S1307G","T1543I","P1640L","S2104I","V2276I","F3027L","I3090T","A3209V","I3255T","H3395P","-3675S","-3676G","-3677F","V3718A","T3750I"],"ORF1b":["G662S","P1000L","T1050I","C1315R","V1566I","I2163T"],"ORF3a":["I223T"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["S10P","-27E","-28N","-29A","T60A"],"S":["-24L","-25S","-26P","S27A","Y144-","E156-","F157-","R158G","P209L","L212S","G213V","D215H","A222V","L242-","A243-","S256L","D339G","G446S","F486P","R493Q","N703I"]},"labels":{"aa":"E: I9T; M: E19Q, T63A, I82T; N: L13P, -31E, -32R, -33S, D63G, K203M, R204G, D377Y, R413S; ORF1a: S1307G, T1543I, P1640L, S2104I, V2276I, F3027L, I3090T, A3209V, I3255T, H3395P, -3675S, -3676G, -3677F, V3718A, T3750I; ORF1b: G662S, P1000L, T1050I, C1315R, V1566I, I2163T; ORF3a: I223T; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: S10P, -27E, -28N, -29A, T60A; S: -24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I","spike_mutations":"-24L, -25S, -26P, S27A, Y144-, E156-, F157-, R158G, P209L, L212S, G213V, D215H, A222V, L242-, A243-, S256L, D339G, G446S, F486P, R493Q, N703I"}},"children":[{"name":"XBC","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-24"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC"},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000055","node_attrs":{"div":68,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000056","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":58},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"XBC.2"},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.2.1"},"immune_escape":{"value":"0.44507236664312827"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000057","node_attrs":{"div":70,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":57},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"XBC.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":76,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.4"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":75,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.5"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000059","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":7},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.2.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.2.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000060","node_attrs":{"div":78,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000061","node_attrs":{"div":79,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}},{"name":"XBC.1.1.1","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.1.1"},"immune_escape":{"value":"0.48837241784414276"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}}]}]},{"name":"NODE_0000062","node_attrs":{"div":76,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":76,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7.1"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.7.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.7.2"},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000063","node_attrs":{"div":72,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":78,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000065","node_attrs":{"div":79,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.2"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.1","node_attrs":{"div":80,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.3","node_attrs":{"div":81,"totalAminoacidDeletions":{"value":21},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.3"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":83,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KD.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.3.1.4"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}}]}]}]},{"name":"NODE_0000066","node_attrs":{"div":84,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":84,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":87,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.4"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.4"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":88,"totalAminoacidDeletions":{"value":11},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.5"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.5"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000067","node_attrs":{"div":85,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":88,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.1.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":85,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":87,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":89,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JT.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.6.1"},"immune_escape":{"value":"0.7550301657183831"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":87,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.6"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000069","node_attrs":{"div":86,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":86,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000070","node_attrs":{"div":89,"clade_membership":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_display":{"value":"recombinant"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.1","node_attrs":{"div":92,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.1"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"immune_escape":{"value":"0.7420325830319254"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1.2","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.2"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1.3","node_attrs":{"div":90,"totalAminoacidDeletions":{"value":8},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"recombinant"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HW.1.3"},"clade_who":{"value":"recombinant"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":26,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","A405G","C9866T","T11288-","T11289-","T11290-","T11291-","T11292-","T11293-","T11294-","T11295-","T11296-","G15451A","C15738T","T15939C","T16342C","T17859C","A19326G","T21633-","T21634-","T21635-","T21636-","T21637-","T21638-","T21639-","T21640-","T21641-","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T22942G","T23019C","T23031C","G23040A","C25416T","A26275G","T28362-","T28363-","T28364-","T28365-","T28366-","T28367-","T28368-","T28369-","T28370-","T29734-","T29735-","T29736-","T29737-","T29738-","T29739-","T29740-","T29741-","T29742-","T29743-","T29744-","T29745-","T29746-","T29747-","T29748-","T29749-","T29750-","T29751-","T29752-","T29753-","T29754-","T29755-","T29756-","T29757-","T29758-","T29759G"],"E":["T11A"],"ORF1a":["K47R","L3201F"],"ORF1b":["G662S","S959P"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","N460K","F486S","F490S","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: K47R, L3201F; ORF1b: G662S, S959P; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q","clade":"22F","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, N460K, F486S, F490S, R493Q"}},"children":[{"name":"XBB","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000072","node_attrs":{"div":26,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.223455429077148}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000073","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.207023620605469}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.390348434448242}},"branch_attrs":{"mutations":{"nuc":["C14178T","-29759G"]}}},{"name":"XBB.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000074","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.654644012451172}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.4"},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.3064099999999999"},"placement_prior":{"value":-4.654644012451172}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.4.1"},"immune_escape":{"value":"1.0810114368008295"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.26627999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000075","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.116074562072754}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.232290267944336}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.6.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C14178T","C14362T","C14574T","C22792A","C25539T"]}}},{"name":"XBB.8.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}},{"name":"XBB.8.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.8.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.479925632476807}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.479925632476807}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"NODE_0000080","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.121950149536133}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.121950149536133}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.148683547973633}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.256861209869385}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"NODE_0000081","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.453329563140869}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.453329563140869}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.11.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.11.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}}]},{"name":"NODE_0000082","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219453811645508}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.219453811645508}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.7.1"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65097"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.83268404006958}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"internal_d796","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.6","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"NODE_0000086","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.6.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":34,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.717053174972534}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-3.717053174972534}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.14","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.14"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.8983306884765625}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.20","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.20"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.18","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.18"},"immune_escape":{"value":"1.2567103717994188"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.0750199999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.22","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.22"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.21","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.21"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.5","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-12"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"placement_prior":{"value":-4.42367696762085}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.45538854598999}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.9"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.674048900604248}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"placement_prior":{"value":-4.709936141967773}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"placement_prior":{"value":-4.674048900604248}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"placement_prior":{"value":-4.8618388175964355}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.13"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.033972263336182}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"immune_escape":{"value":"1.0527558336884004"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84789"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.12"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.90647"},"placement_prior":{"value":-4.900045394897461}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.16"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.17"},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.15"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":43,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}},{"name":"JY.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-19"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GM.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"immune_escape":{"value":"0.9736186906064397"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89932"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HG.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.646721839904785}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.646721839904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.761235237121582}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000102","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"immune_escape":{"value":"1.0079043361863298"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.7709600000000001"},"placement_prior":{"value":-4.985507965087891}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000103","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.606808662414551}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.55094575881958}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GS.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.517807483673096}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.703529357910156}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.703529357910156}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.552662372589111}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.8","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_bb69915a","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.388531684875488}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":41,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}},{"name":"HH.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":40,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.671622276306152}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HH.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.4304351806640625}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.4304351806640625}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.898563385009766}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.898563385009766}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":37,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8265013694763184}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.568424701690674}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"immune_escape":{"value":"0.986824739722089"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.70075"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"GE.1.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000120","node_attrs":{"div":45,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":49,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":50,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"KT.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KT.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":35,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.253464221954346}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.253464221954346}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":36,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.2032599449157715}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.218527317047119}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"GJ.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_27e82a71","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":38,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.6877522468566895}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-02"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.6877522468566895}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":39,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":41,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000130","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.5","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}}]},{"name":"internal_18110768","node_attrs":{"div":42,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":46,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":47,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":48,"clade_membership":{"value":"23E"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":27,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.052709102630615}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1.10","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.10"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13558"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.052709102630615}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.3","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.3"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.49564"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0545"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.49"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.89405"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.535830020904541}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.20"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.48"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.9722600000000003"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3403778076171875}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.3403778076171875}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"GW.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"XBB.1.19.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":41,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"GW.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}}]},{"name":"NODE_0000141","node_attrs":{"div":46,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":48,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":48,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":54,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.1","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.3","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":28,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1255195140838623}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86729"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.27"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.2602599999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.29"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.36"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-5.3860321044921875}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.40"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.6","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.885027885437012}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.8","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.12"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.12.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.12.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.709931373596191}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-4.709931373596191}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.13.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.15"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.15.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000149","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.14.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.14.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_18e1f6df","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.220515251159668}},"branch_attrs":{"mutations":{"nuc":["G709T","T13704C"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.32.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.32","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.220515251159668}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8d12","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.37.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.37.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_234859ae","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.928167819976807}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.38"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.928167819976807}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.38.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.066565036773682}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.254011631011963}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.43"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.254011631011963}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.43.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.43.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344058036804199}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.44"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.344058036804199}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.44.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.44.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.038851737976074}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.45"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.038851737976074}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.45.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.45.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000156","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31.1"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.31.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.31.2"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.7139763832092285}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.7139763832092285}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-25"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-3.9892516136169434}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.34","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_5dcf3700","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.34.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.569494247436523}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.05231"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000161","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.810415744781494}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.085368633270264}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"FW.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-4.810415744781494}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000162","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.343214511871338}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.343214511871338}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962552070617676}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.962552070617676}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.714374542236328}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000167","node_attrs":{"div":38,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000168","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FP.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.7388600000000002"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FP.2.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69644832611084}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.69644832611084}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":31,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.357577323913574}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.357577323913574}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.77537202835083}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"FE.1.1.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.5","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000173","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":40,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"NODE_0000175","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6362106800079346}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.079745769500732}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.30","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.30"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.744277477264404}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.35","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.39","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.069783687591553}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"XBB.1.46","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.46"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.47"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-6.903770923614502}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.47.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.47.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000177","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.1"},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.05408"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000178","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.24.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.24.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"NODE_0000179","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.73932409286499}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"placement_prior":{"value":-6.73932409286499}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.2"},"immune_escape":{"value":"1.1099290580037755"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.6066099999999999"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3"},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000181","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.804386615753174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000183","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000184","node_attrs":{"div":40,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"internal_b1afb4e5","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.43418"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}},{"name":"JC.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"NODE_0000187","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000188","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.089523792266846}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000189","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.10.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-03"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}}]},{"name":"NODE_0000190","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000191","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.96117"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000192","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000193","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.2.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80721"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}}]}]},{"name":"NODE_0000194","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.90647"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000195","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000196","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000197","node_attrs":{"div":46,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}},{"name":"GA.4.1.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GA.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":30,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7918386459350586}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7918386459350586}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.110"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.110"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.23376989364624}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.43"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.543598651885986}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.45"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.58","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.58"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.57","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.57"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.87","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.87"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.87"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93509"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.873802423477173}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.062389373779297}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.873802423477173}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000200","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2794275283813477}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.101","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.101"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.101"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.10","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.10"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.755887031555176}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.104","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.104"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.104"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0973687171936035}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.109","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.109"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.109"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9660911560058594}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.653730630874634}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7371788024902344}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.007676124572754}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.29","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.29"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.41404999999999986"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.26","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4117631912231445}},"branch_attrs":{"mutations":{"nuc":["C920T"]}}},{"name":"XBB.1.5.28","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.861788511276245}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.31","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.31"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8877837657928467}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.33","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.6405656337738037}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.35","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.063141822814941}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.34","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.282281398773193}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.36","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.36"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.254117965698242}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.40"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.95377"},"placement_prior":{"value":-4.218836784362793}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.51"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.948964834213257}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.52","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.52"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8478782176971436}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.54"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.59"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.107715606689453}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.63","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.63"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7518346309661865}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.62","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.62"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.189910888671875}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.64"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.1709489822387695}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.67"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7762694358825684}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.69","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.69"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.275579452514648}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.66","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.66"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.801894426345825}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.75","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.75"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.35540246963501}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.80","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.80"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.80"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.274980068206787}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.79"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.6546549797058105}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.82","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.82"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.82"},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.91194"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.85"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.85"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.914968967437744}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.98","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.98"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.98"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.99"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.99"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.521303653717041}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"XBB.1.5.97","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.97"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.97"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.439826965332031}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"NODE_0000201","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.362831115722656}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.174068450927734}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.362831115722656}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000202","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.663084030151367}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.396157264709473}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.663084030151367}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.7630462646484375}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.8095383644104}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.38"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.7630462646484375}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000204","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.283175945281982}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"HA.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.7958831787109375}},"branch_attrs":{"mutations":{"nuc":["A11399G","T22930A"],"ORF1a":["M3712V"],"S":["F456L"]},"labels":{"aa":"ORF1a: M3712V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.86","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.283175945281982}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9230175018310547}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.943152904510498}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9230175018310547}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.136342525482178}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"immune_escape":{"value":"1.1023732112409157"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.29094"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.30"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.41123000000000004"},"placement_prior":{"value":-4.136342525482178}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738136291503906}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.92"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.738136291503906}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.4955267906188965}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.282939434051514}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.100"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4955267906188965}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7568650245666504}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-4.850849628448486}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-29"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.3"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-3.7568650245666504}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5239129066467285}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.971319675445557}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.107"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.5239129066467285}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.995249032974243}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-01-31"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.995249032974243}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000212","node_attrs":{"div":31,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.403249740600586}},"branch_attrs":{"mutations":{"nuc":["A22474C"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"XBB.1.5.105","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.105"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.105"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I"}}},{"name":"XBB.1.5.108","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.108"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.108"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","C22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_101d8393","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.400269508361816}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.50"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.71"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.48403999999999986"},"placement_prior":{"value":-4.380550861358643}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000214","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277669906616211}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"GC.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"immune_escape":{"value":"1.03073601411565"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9061"},"placement_prior":{"value":-4.990260124206543}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"XBB.1.5.21","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.277669906616211}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000215","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.036886692047119}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.036886692047119}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000216","node_attrs":{"div":41,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.7416800000000001"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.73864"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266819953918457}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.266819953918457}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"HP.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.286570072174072}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.286570072174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000220","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.9992594718933105}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.021956920623779}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.1186099999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.693673133850098}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.512119770050049}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.16"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.021956920623779}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000222","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000223","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000224","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000225","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}}]}]},{"name":"NODE_0000226","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.875742435455322}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000227","node_attrs":{"div":39,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000228","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.576870918273926}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"immune_escape":{"value":"1.0346353162114479"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9873000000000001"},"placement_prior":{"value":-5.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.174642086029053}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.576870918273926}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000229","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EK.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000230","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.037446975708008}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"HA.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-4.925134181976318}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"ORF1a":["G2868S","M3712V"]},"labels":{"aa":"ORF1a: G2868S, M3712V"}}},{"name":"NODE_0000231","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{"nuc":["C920T","C21910A"]}},"children":[{"name":"EU.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"placement_prior":{"value":-5.0851054191589355}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":36,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.314939498901367}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-11"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EU.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}}]}]}]},{"name":"NODE_0000233","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.349449157714844}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.842705249786377}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.349449157714844}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000234","node_attrs":{"div":36,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000235","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.514014720916748}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.852022647857666}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.852022647857666}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425598621368408}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.425598621368408}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":39,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000239","node_attrs":{"div":42,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":41,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000241","node_attrs":{"div":42,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000242","node_attrs":{"div":44,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"immune_escape":{"value":"1.2868306565498102"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.20635"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000243","node_attrs":{"div":43,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JD.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376293182373}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.5","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-04"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"immune_escape":{"value":"1.3046787170970133"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.1261900000000002"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.4","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JD.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}}]}]}]}]}]},{"name":"NODE_0000244","node_attrs":{"div":41,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-22"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000245","node_attrs":{"div":43,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":43,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000249","node_attrs":{"div":42,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.4253100000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":44,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.4","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":47,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"internal_3ae12761","node_attrs":{"div":44,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":46,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":48,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":45,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":46,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":52,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000258","node_attrs":{"div":49,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000259","node_attrs":{"div":51,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":52,"clade_membership":{"value":"23G"},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23G"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"immune_escape":{"value":"1.3541583181563797"},"clade_display":{"value":"23G (XBB.1.5.70)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23G"},"ace2_binding":{"value":"-1.1446400000000003"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000261","node_attrs":{"div":32,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.413428544998169}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.106"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.106"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.20"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.676553726196289}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-18"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.188947677612305}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.27"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.5159149169921875}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.6741859912872314}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.098106384277344}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.56"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.201209545135498}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.60"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.6250386238098145}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.540223121643066}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.61"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.265577793121338}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.65"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.831235408782959}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.72","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.72"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.74","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.74"},"immune_escape":{"value":"1.0169257119491577"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9630099999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.76","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.76"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.102508068084717}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.78"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.81"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.81"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.628146171569824}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.8","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.449199199676514}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.83"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.83"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.5449676513671875}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.84"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.84"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.251712799072266}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.88"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.88"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.2988762855529785}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.89","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.89"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.89"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.9","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.153590202331543}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.90","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.90"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.90"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.91","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.91"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.91"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.224719524383545}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.94"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.94"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.448019504547119}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.96"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.96"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.11193323135376}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000262","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7867274284362793}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.7867274284362793}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000263","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.83085"},"placement_prior":{"value":-4.0655517578125}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.42"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"immune_escape":{"value":"0.9838451476656441"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.83156"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.41"},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185697078704834}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.135185718536377}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.48"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.185697078704834}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000266","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1880059242248535}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.218293190002441}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.103"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.1880059242248535}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"GB.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.9350799999999999"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"XBB.1.5.46","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.46"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.094283580780029}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000269","node_attrs":{"div":43,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8164870738983154}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.592982292175293}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.310765743255615}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-25"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.49"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8164870738983154}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000271","node_attrs":{"div":37,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000272","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}}]},{"name":"NODE_0000273","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-10"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JB.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.024484634399414}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FT.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"immune_escape":{"value":"1.0924169334128189"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.74638"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000278","node_attrs":{"div":33,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8006300926208496}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.89299"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8006300926208496}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":38,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}},{"name":"FD.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":35,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-27"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-01"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.37588357925415}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.37588357925415}},"branch_attrs":{"mutations":{}}},{"name":"FD.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}}]},{"name":"NODE_0000282","node_attrs":{"div":34,"clade_membership":{"value":"23A"},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_display":{"value":"23A (XBB.1.5)"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.037048816680908}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.037048816680908}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"23A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FD.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]}]}]}]}]},{"name":"internal_ORF9b_I5T","node_attrs":{"div":29,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.755037307739258}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.560482025146484}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.20585823059082}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.20585823059082}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000285","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-28"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000286","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"immune_escape":{"value":"0.950188045949472"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.86018"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"immune_escape":{"value":"0.9788766097021935"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.67693"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":32,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388401985168457}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8926499999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"internal_77ad61e0","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-5.03756856918335}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-06"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}},{"name":"FY.5.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_abb9d504","node_attrs":{"div":34,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.5.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-04"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":39,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-16"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}}]},{"name":"NODE_0000303","node_attrs":{"div":36,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"NODE_0000304","node_attrs":{"div":37,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"FY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FY.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000305","node_attrs":{"div":39,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.996242046356201}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-2.996242046356201}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.11"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-3.181058645248413}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.12"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.10","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.10"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.275190353393555}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.14"},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.7388600000000002"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.16"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.17"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.18"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.089405059814453}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.19"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.20"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.22"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.21"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.23","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.23"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.24","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.24"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.25","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.25"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.26","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.26"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.1853718757629395}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.27","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.27"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-05"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-25"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.8"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.9"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000306","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.32"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000307","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"JM.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"XBB.1.16.15","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-13"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.15"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":40,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.29"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.30"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.31"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000310","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.2","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}}]}]},{"name":"NODE_0000311","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"internal_adf0d069","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121835708618164}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"JF.3","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":45,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"internal_398cc75a","node_attrs":{"div":47,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.028478145599365}},"branch_attrs":{"mutations":{}}},{"name":"JF.1.1.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":40,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.5","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"FU.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-11"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"2.14642"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.16.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}},{"name":"FU.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000318","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.704322576522827}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000319","node_attrs":{"div":44,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FU.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"NODE_0000320","node_attrs":{"div":41,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8164899999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.6","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.7","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.5","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":42,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":43,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000323","node_attrs":{"div":46,"clade_membership":{"value":"23B"},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}},{"name":"GY.1.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":30,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0856804847717285}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000325","node_attrs":{"div":33,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-17"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000326","node_attrs":{"div":35,"clade_membership":{"value":"22F"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.941244125366211}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"22F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.42.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":31,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.210937023162842}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.210937023162842}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"XBB.1.9.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.6"},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.13558"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"NODE_0000328","node_attrs":{"div":33,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.068836212158203}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"GD.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.6875"},"placement_prior":{"value":-4.331231594085693}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.9.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000329","node_attrs":{"div":34,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.389554500579834}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-08"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.063467979431152}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.233525276184082}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.18","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0403361320495605}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"FL.22","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.27","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.406124114990234}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.25","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.529069900512695}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.29","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.7904599999999999"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.216497898101807}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.7","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.6","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-03"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.937436103820801}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.8","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.164567947387695}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.9","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.411857604980469}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.389554500579834}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000330","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C6285T","G12907A","A27507C","C28770T"],"N":["T166I"],"ORF1a":["T2007I"]},"labels":{"aa":"N: T166I; ORF1a: T2007I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.18.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]},{"name":"NODE_0000331","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"immune_escape":{"value":"0.9957660361777405"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0848"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.30.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"FL.31.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}}]},{"name":"NODE_0000336","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.33.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.515424728393555}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.33","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_14b9e262","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.35.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.917665481567383}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.81109"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000340","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9744789600372314}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9744789600372314}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.17.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-26"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.5920999999999998"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.20.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.21.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"FL.10.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"immune_escape":{"value":"1.1216394663867173"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.98073"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000345","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000346","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.96117"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.23.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8835"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000347","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.186100482940674}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.2","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}},{"name":"FL.3.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.066182613372803}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}}]},{"name":"NODE_0000348","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.282326698303223}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.282326698303223}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.47537999999999986"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":35},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_10382b90","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.65389347076416}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.13.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.671235084533691}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000353","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.594952583312988}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000354","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"internal_24b5ee08","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000356","node_attrs":{"div":41,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000357","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000358","node_attrs":{"div":48,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-09-27"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000359","node_attrs":{"div":49,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}},{"name":"KF.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}}]}]}]}]}]}]}]},{"name":"internal_7f0cfce5","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.5","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.670197010040283}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"internal_fc124546","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"FL.2.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-12-21"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.2.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_95ea4775","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.9449143409729004}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.457831382751465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.93509"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"immune_escape":{"value":"1.0186868047371063"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.48144"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.3348299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000367","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}},{"name":"FL.4.6","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.689967155456543}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.3","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.7","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.78812"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-29"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-05-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-13"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"immune_escape":{"value":"0.9778643306477401"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.89211"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.5332231521606445}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000372","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-23"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.06800999999999986"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000373","node_attrs":{"div":47,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{}}},{"name":"KC.1.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KC.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}}]}]},{"name":"NODE_0000374","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-06"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.36653995513916}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000375","node_attrs":{"div":46,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000376","node_attrs":{"div":47,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"immune_escape":{"value":"1.3005141566416802"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.0007299999999998658"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000377","node_attrs":{"div":43,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232717037200928}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000378","node_attrs":{"div":45,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000379","node_attrs":{"div":44,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-17"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000380","node_attrs":{"div":35,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.618598222732544}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.13","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.12","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.11","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.919648170471191}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.14","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.8","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"EG.7","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-06-09"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1186099999999999"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.618598222732544}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.20938"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.397416591644287}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"placement_prior":{"value":-5.397416591644287}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000383","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.10.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":39,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.6.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000386","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.091670513153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.091670513153076}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.5","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.4","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.86275"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317834377288818}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.317834377288818}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.3","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.169593811035156}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.346397876739502}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.4","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}},{"name":"EG.4.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"placement_prior":{"value":-4.917497158050537}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":36,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3095011711120605}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000389","node_attrs":{"div":37,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.541221857070923}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.541221857070923}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.2","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.088577747344971}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.5","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.569139003753662}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.6","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-3.8091061115264893}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"EG.1.7","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-5.115445613861084}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"internal_e85bc240","node_attrs":{"div":38,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.4007978439331055}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-06-30"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}}]}]}]},{"name":"NODE_0000391","node_attrs":{"div":40,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173191070557}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000392","node_attrs":{"div":42,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"NODE_0000393","node_attrs":{"div":46,"clade_membership":{"value":"23D"},"Nextclade_pango":{"value":"EG.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000394","node_attrs":{"div":42,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.292908191680908}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.13","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.16","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.18","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.374487400054932}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.2","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.19","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.585853576660156}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.5","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-08-25"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":43,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":43,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-6.477802276611328}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000398","node_attrs":{"div":49,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-11-29"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JR.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"immune_escape":{"value":"1.4312755323086508"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.73257"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000399","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.459355354309082}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000400","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":44,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.350670576095581}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000402","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.3","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.8333635330200195}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9912302494049072}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.4253100000000001"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.4","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JG.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000403","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000404","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.10","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.025979999999999802"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1.11","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"immune_escape":{"value":"1.3341105633249508"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.0887599999999999"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.4","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.3","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"immune_escape":{"value":"1.3005451981781486"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.21974"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.8","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.7","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"internal_2378868c","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043656826019287}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.048559999999999943"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"immune_escape":{"value":"1.3552393372267753"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.38161000000000006"},"placement_prior":{"value":-4.412596225738525}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000406","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000407","node_attrs":{"div":52,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000408","node_attrs":{"div":53,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000409","node_attrs":{"div":45,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-20"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.1727359294891357}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"immune_escape":{"value":"1.1972306507819483"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.13706999999999997"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.19","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.21","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"immune_escape":{"value":"1.205901853206978"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.1481699999999999"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"immune_escape":{"value":"1.310148541751831"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.49366"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-11-27"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.31","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.25141716003418}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.30","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.32","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.4","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-08-30"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}},{"name":"HK.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.812265872955322}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.2","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"immune_escape":{"value":"1.2183176254438959"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.6088199999999999"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.002764701843262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000416","node_attrs":{"div":51,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.23.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"immune_escape":{"value":"1.3534097328298118"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.48614000000000007"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000420","node_attrs":{"div":48,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.27.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.570084095001221}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":52,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.34.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"NODE_0000424","node_attrs":{"div":50,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2.1","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}},{"name":"HK.13.2","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":46,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.15","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.16","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-13"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":47,"clade_membership":{"value":"23F"},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-09-01"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23F"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":46,"clade_membership":{"value":"23H"},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_display":{"value":"23H (HK.3)"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-23"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-08-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.11","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.12","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.13","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.10","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.14","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2024-01-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-1.0860600000000002"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.5","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.4","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.3","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.7","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.9","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.3123884201049805}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-5.316434383392334}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_ca7dc568","node_attrs":{"div":49,"clade_membership":{"value":"23H"},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_display":{"value":"23H (HK.3)"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-11-24"},"clade_membership":{"value":"23H"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"HK.3.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"internal_16e4","node_attrs":{"div":0,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1026320457458496}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.15","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.15"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.830389499664307}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.16","node_attrs":{"div":1,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.16"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.232675552368164}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.19","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.19"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.5045647621154785}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":1,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.29116153717041}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":41},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.87.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.87.1"},"immune_escape":{"value":"0.6657453429914796"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.8217399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","C22000-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}},{"name":"BA.2.87","node_attrs":{"div":1,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.87"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.29116153717041}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a01b","node_attrs":{"div":19,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.702070713043213}},"branch_attrs":{"mutations":{"nuc":["T2790C","T9344C","G9424A","T10198C","T17410C","T19955C","G20055A","T21618C","-21633T","-21634A","-21635C","-21636C","-21637C","-21638C","-21639C","-21640T","-21641G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22200T","G22688A","C22786A","G22898A","T25000C","T25584C","C27382G","T27383A","C27384T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A"],"ORF1a":["I842T","F3027L"],"ORF1b":["C1315R","I2163T"],"ORF6":["L61D"],"S":["I19T","-24L","-25P","-26P","S27A","A67V","H69-","V70-","T95I","V143-","Y144-","Y145-","N211-","L212I","G213V","A376T","S408R","G446S"]},"labels":{"aa":"ORF1a: I842T, F3027L; ORF1b: C1315R, I2163T; ORF6: L61D; S: I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S","clade":"outgroup","spike_mutations":"I19T, -24L, -25P, -26P, S27A, A67V, H69-, V70-, T95I, V143-, Y144-, Y145-, N211-, L212I, G213V, A376T, S408R, G446S"}},"children":[{"name":"BA.3","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":44},"designation_date":{"value":"2021-12-14"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.3"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}}},{"name":"21M","node_attrs":{"div":30,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.8285975456237793}},"branch_attrs":{"mutations":{"nuc":["G670T","A4184G","T4321C","T9534C","A10447G","T12880C","T15714C","A22775G","T26060C","T26858C","C29510A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"N":["R413S"],"ORF1a":["R135S","S1307G","I3090T","-3677F"],"ORF3a":["I223T"],"S":["N405D"]},"labels":{"aa":"N: R413S; ORF1a: R135S, S1307G, I3090T, -3677F; ORF3a: I223T; S: N405D","spike_mutations":"N405D"}},"children":[{"name":"BA.1","node_attrs":{"div":44,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":46},"designation_date":{"value":"2021-12-07"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.807489812374115}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","-11294T","-11295T","-11296T","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}}},{"name":"20B","node_attrs":{"div":60,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.9172141551971436}},"branch_attrs":{"mutations":{"nuc":["T10029C","A10449C","G18163A","T21762C","T21846C","-21987G","-21988T","-21989G","-21990T","-21991T","-21995T","-22194A","-22195T","-22196T","A22578G","T22674C","C22679T","T22686C","T22813G","G22882T","A22898G","A22992G","A22995C","C23013A","G23040A","G23055A","C23075T","T23525C","G23599T","A23854C","T23948G","T24424A","A24469T","T26270C","G26577C","A26709G","C27259A","T27807C","T28311C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"E":["I9T"],"M":["E19Q","T63A"],"N":["L13P","-31E","-32R","-33S"],"ORF1a":["I3255T","H3395P"],"ORF1b":["V1566I"],"ORF9b":["S10P","-27E","-28N","-29A"],"S":["V67A","I95T","D142G","-143V","-145Y","-211N","I212L","D339G","F371S","P373S","F375S","N417K","K440N","S446G","N477S","K478T","A484E","R493Q","R498Q","H505Y","Y655H","K679N","K764N","Y796D","H954Q","K969N"]},"labels":{"aa":"E: I9T; M: E19Q, T63A; N: L13P, -31E, -32R, -33S; ORF1a: I3255T, H3395P; ORF1b: V1566I; ORF9b: S10P, -27E, -28N, -29A; S: V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N","spike_mutations":"V67A, I95T, D142G, -143V, -145Y, -211N, I212L, D339G, F371S, P373S, F375S, N417K, K440N, S446G, N477S, K478T, A484E, R493Q, R498Q, H505Y, Y655H, K679N, K764N, Y796D, H954Q, K969N"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":79,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":18},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.1.7"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.1350864171981812}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","C14676T","C15279T","T16176C","C23271A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","T28270-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["A570D","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, F3677-; ORF8: Q27*, R52I, Y73C; S: A570D, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"A570D, T716I, S982A, D1118H"}}},{"name":"NODE_0000434","node_attrs":{"div":63,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8541454076766968}},"branch_attrs":{"mutations":{"nuc":["-11288T","-11289C","-11290T","-11291G","-11292G","-11293T","-11294T","-11295T","-11296T","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","-21992T","-21993A","-21994T","T23063A","A23604C","T28271A"],"ORF1a":["-3675S","-3676G"],"S":["-69H","-70V","-144Y","Y501N","H681P"]},"labels":{"aa":"ORF1a: -3675S, -3676G; S: -69H, -70V, -144Y, Y501N, H681P","spike_mutations":"-69H, -70V, -144Y, Y501N, H681P"}},"children":[{"name":"B.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.8541454076766968}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000435","node_attrs":{"div":66,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066986083984375}},"branch_attrs":{"mutations":{"nuc":["A28881G","A28882G","C28883G"],"N":["K203R","R204G"]},"labels":{"aa":"N: K203R, R204G"}},"children":[{"name":"B.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-1.5066986083984375}},"branch_attrs":{"mutations":{}}},{"name":"B.1.617.2","node_attrs":{"div":83,"totalAminoacidDeletions":{"value":2},"totalAminoacidSubstitutions":{"value":19},"designation_date":{"value":"2021-04-21"},"clade_membership":{"value":"outgroup"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B.1.617.2"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-0.5602865815162659}},"branch_attrs":{"mutations":{"nuc":["G210T","G15451A","C16466T","C21618G","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22917G","C22995A","C23604G","G24410A","C25469T","T26767C","T27638C","C27752T","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1b":["G662S","P1000L"],"ORF3a":["S26L"],"ORF7a":["V82A","T120I"],"ORF9b":["T60A"],"S":["T19R","G142D","E156-","F157-","R158G","L452R","T478K","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1b: G662S, P1000L; ORF3a: S26L; ORF7a: V82A, T120I; ORF9b: T60A; S: T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N","spike_mutations":"T19R, G142D, E156-, F157-, R158G, L452R, T478K, P681R, D950N"}}},{"name":"19A","node_attrs":{"div":70,"clade_membership":{"value":"outgroup"},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{"nuc":["T241C","T3037C","T14408C","G23403A"],"ORF1b":["L314P"],"S":["G614D"]},"labels":{"aa":"ORF1b: L314P; S: G614D","spike_mutations":"G614D"}},"children":[{"name":"A","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"A"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"A"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-2.94581937789917}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S"}}},{"name":"B","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":0},"totalAminoacidSubstitutions":{"value":0},"clade_membership":{"value":"outgroup"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"B"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"B"},"clade_display":{"value":"outgroup"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"outgroup"},"placement_prior":{"value":-3.075068235397339}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"internal_c0ce","node_attrs":{"div":1,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4849481582641602}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.9632513523101807}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.11"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"placement_prior":{"value":-4.008795738220215}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.18"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.06190824508667}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.20"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.934055805206299}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.24"},"immune_escape":{"value":"0.01261797446067892"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.03172000000000008"},"placement_prior":{"value":-3.048215866088867}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.28","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.28"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.9567365646362305}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.26","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.26"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.5785768032073975}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.27","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.27"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9515457153320312}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.29","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.29"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2466073036193848}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.30","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.30"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.192726135253906}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.32"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7269387245178223}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.39","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-05-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.39"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.341081619262695}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.4","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.4"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7649905681610107}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.42","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-18"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.42"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.41","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.41"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.732407331466675}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.46","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.46"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.784368991851807}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.43","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.43"},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"placement_prior":{"value":-4.411663055419922}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.5","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.5907039642333984}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.48","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.48"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7901194095611572}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.50"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.213821887969971}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.55","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.55"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.216464519500732}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.54","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.54"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.137808799743652}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.58"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.060901165008545}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.59","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.59"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.600815296173096}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.61","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.61"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.497117042541504}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.62"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.002071380615234}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.60","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.60"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.64","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.64"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.522981643676758}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.63","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.63"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.172652721405029}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.65","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.65"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.866844415664673}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.70","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.70"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.473325729370117}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.77"},"immune_escape":{"value":"0.3221048136122174"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9213199999999999"},"placement_prior":{"value":-5.606687545776367}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.8"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.326139450073242}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.82","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.82"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.82"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-5.217201232910156}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.83","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.83"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.83"},"immune_escape":{"value":"0.22071783986880583"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.12534"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.85"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.85"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.306359767913818}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000438","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.565203905105591}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.565203905105591}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.2.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000439","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1365203857421875}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":49},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.23"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1365203857421875}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.23.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.825143814086914}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.31.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.869024753570557}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.31","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.31"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.825143814086914}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000441","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8949601650238037}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.33"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.087352275848389}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}},{"name":"BA.2.35","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-29"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.35"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"placement_prior":{"value":-4.571066856384277}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020925521850586}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.40.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.40.1"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.7483084201812744}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.40","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.40"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8020925521850586}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000443","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.982405185699463}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.56.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.56.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.698922157287598}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}},{"name":"BA.2.56","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.56"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-2.982405185699463}},"branch_attrs":{"mutations":{}}}]},{"name":"BA.2.10_internal","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.6351211071014404}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":2,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.6351211071014404}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.2","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.685215473175049}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.3","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.082213878631592}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.4","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.4"},"immune_escape":{"value":"0.3166622371297313"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.73328"},"placement_prior":{"value":-5.095425605773926}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4718618392944336}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.4718618392944336}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.10.1.1"},"immune_escape":{"value":"0.6181860283242497"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.09519000000000005"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000446","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.908740520477295}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.14"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.693842649459839}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.22"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2798104286193848}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.34"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.117501735687256}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.36"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.0866947174072266}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.47","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.47"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.130222797393799}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.49"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8066627979278564}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.51","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.51"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7612979412078857}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.52"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8890013694763184}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.6","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.6"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.6700806617736816}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.69"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.045757293701172}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.7","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-03-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.384455680847168}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.72","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.72"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7303617000579834}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.71","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.71"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.731685161590576}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.81","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.81"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.81"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.353763580322266}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.80","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.80"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.80"},"immune_escape":{"value":"0.31190394480802347"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10838000000000005"},"placement_prior":{"value":-5.6476006507873535}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"internal_6dd8","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.25"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.515312671661377}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.25.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.996367454528809}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"NODE_0000448","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.908740520477295}},"branch_attrs":{"mutations":{}},"children":[{"name":"BA.2.45","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-23"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.45"},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.30756000000000006"},"placement_prior":{"value":-3.734736680984497}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.53","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.53"},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.33552999999999994"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}}]},{"name":"internal_8e5d","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.7460718154907227}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.44"},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"placement_prior":{"value":-4.219630718231201}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5670673847198486}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.13"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-3.5670673847198486}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.13.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.0240631103515625}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1937501430511475}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.1937501430511475}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-04-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.3531692028045654}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.4"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.2","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.628756284713745}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.5","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.2406184673309326}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.6"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.506667613983154}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.9.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.9.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.828467607498169}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000452","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.4851491451263428}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3.10","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.10"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.09907865524292}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.1","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-01"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.1"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.1285204887390137}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-02-25"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-2.4851491451263428}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.11","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.11"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7979793548583984}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.14","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.14"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.958454132080078}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.13","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.13"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.348191499710083}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.12","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.12"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.15","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.15"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8729355335235596}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.17","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.17"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8992807865142822}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.18","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.18"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.462960243225098}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.19","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":6},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.19"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-4.702410697937012}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.4","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-20"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.4"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.5","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.5"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.302166938781738}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.7","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.7"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8020241260528564}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.9","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.9"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.8521687984466553}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"BA.2.3.8","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.8"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"internal_305a","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.16"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9121878147125244}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.16.1"},"immune_escape":{"value":"0.43687237373984505"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9456899999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601692199707031}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.21"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06758"},"placement_prior":{"value":-4.830438613891602}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.21.1"},"immune_escape":{"value":"0.4733677107846063"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9683399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000455","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17173957824707}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.6","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.6"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.009570121765137}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}},{"name":"BA.2.3.22","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.22"},"immune_escape":{"value":"0.42289430257523936"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.37526000000000004"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}}]},{"name":"internal_019b","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9328737258911133}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-04-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9328737258911133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000457","node_attrs":{"div":29,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"immune_escape":{"value":"0.6029918987948071"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.6589000000000002"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-09-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1"},"immune_escape":{"value":"0.49181526572268314"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.66194"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BS.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"immune_escape":{"value":"0.4975483601650658"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.66821"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000458","node_attrs":{"div":26,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.10"},"immune_escape":{"value":"0.7593324873420084"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.8190299999999999"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000459","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.4"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"immune_escape":{"value":"0.7016283989012374"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.91683"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":27,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.6"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"immune_escape":{"value":"0.8143059671640498"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9440299999999998"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8"},"immune_escape":{"value":"0.7255583352017505"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.99403"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000463","node_attrs":{"div":30,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000464","node_attrs":{"div":31,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000465","node_attrs":{"div":35,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-04-26"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"immune_escape":{"value":"1.0761544902802131"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.28625999999999996"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":27,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.11","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.11"},"immune_escape":{"value":"1.0179803928276123"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.35566999999999993"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.12","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.12"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.3","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.3"},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.9"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-5.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":28,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.2"},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"placement_prior":{"value":-4.420136451721191}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000468","node_attrs":{"div":29,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000469","node_attrs":{"div":30,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-30"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"placement_prior":{"value":-5.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-14"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CM.7.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"immune_escape":{"value":"0.9785485534494837"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.9729599999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":2,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1254796981811523}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.17"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.11018180847168}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.21"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-03"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.37"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.095773220062256}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.57"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.153290271759033}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.66"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.675938129425049}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.68"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.929081678390503}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.73"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.0335774421691895}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-23"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.74"},"immune_escape":{"value":"0.33134042675697756"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.21698000000000003"},"placement_prior":{"value":-3.8886899948120117}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.78"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"placement_prior":{"value":-4.664786338806152}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000471","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0964372158050537}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.67"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000472","node_attrs":{"div":6,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.79"},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"placement_prior":{"value":-4.719792366027832}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.79.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.79.1"},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000473","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.63395619392395}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-02"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-3.63395619392395}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000474","node_attrs":{"div":6,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76.1"},"immune_escape":{"value":"0.2640232066165751"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.18492"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}},{"name":"BA.2.76.2","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.76.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.76.2"},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4425623416900635}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":3,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38"},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"placement_prior":{"value":-3.4425623416900635}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":8,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.741132736206055}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.3"},"immune_escape":{"value":"0.07383293656037815"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.08445999999999997"},"placement_prior":{"value":-4.741132736206055}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-08"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.3.1"},"immune_escape":{"value":"0.370455061085298"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0.11188000000000006"},"placement_prior":{"value":-4.580904006958008}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000477","node_attrs":{"div":3,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.986060619354248}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-07"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.1"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.085832118988037}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000478","node_attrs":{"div":5,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.909948348999023}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.2"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.38.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.38.4"},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"placement_prior":{"value":-4.449790954589844}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7789523601531982}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":4,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12"},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"-0"},"placement_prior":{"value":-3.7789523601531982}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-11"},"clade_membership":{"value":"21L"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.2"},"immune_escape":{"value":"0.062348652344665065"},"clade_display":{"value":"21L (BA.2)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"21L"},"ace2_binding":{"value":"0.07350000000000005"},"placement_prior":{"value":-3.9584996700286865}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000480","node_attrs":{"div":5,"clade_membership":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0569682121276855}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.0569682121276855}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000481","node_attrs":{"div":7,"clade_membership":{"value":"22C"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_display":{"value":"22C (BA.2.12.1)"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292356729507446}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.2","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-06-18"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.2"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.0345394611358643}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.3","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.3"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.5","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-28"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.5"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.1","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-14"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.1"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.4","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.4"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.6","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-01"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.6"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}},{"name":"BG.7","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BG.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.12.1.7"},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":18,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8684661388397217}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-3.8684661388397217}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.10"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.499698162078857}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.7","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.7"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-4.55503511428833}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"BA.2.75.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.8"},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04854"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"internal_2dc7","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.7365007400512695}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.9"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.7365007400512695}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.9.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"placement_prior":{"value":-4.5146331787109375}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4"},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.13451"},"placement_prior":{"value":-5.475138187408447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000485","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.2"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"placement_prior":{"value":-3.378986120223999}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.3"},"immune_escape":{"value":"0.5588825437629772"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.24593"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000487","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"immune_escape":{"value":"0.7451886007636047"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.12575999999999996"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000488","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.4"},"immune_escape":{"value":"0.5013910005227346"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.10514"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000489","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}},{"name":"BR.5","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.4.5"},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.099649429321289}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.099649429321289}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.4"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000491","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210728168487549}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.5"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.16854"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000492","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.586776256561279}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.586776256561279}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.043233394622803}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000493","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.19193"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.3464399999999999"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"immune_escape":{"value":"0.6011952983295785"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.56756"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BL.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.1.6"},"immune_escape":{"value":"0.5544855553668998"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.11979"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.636732578277588}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-4.636732578277588}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.278948783874512}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.278948783874512}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.083024501800537}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}},{"name":"BY.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-5.083024501800537}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_147e","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.546010971069336}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BY.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-08-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-3.726360559463501}},"branch_attrs":{"mutations":{}}},{"name":"CA.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.2"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"placement_prior":{"value":-4.7165374755859375}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.4","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.4"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.5"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.7"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"CA.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.6"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"internal_80b8","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.0229573249816895}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CA.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.2371799999999999"},"placement_prior":{"value":-4.580175399780273}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096994400024414}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.096994400024414}},"branch_attrs":{"mutations":{}}},{"name":"BN.5","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.5"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.532908916473389}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"BN.6","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.6"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-4.629100322723389}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.4","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.4"},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"placement_prior":{"value":-4.784391403198242}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"internal_40f9","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215889930725098}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}},{"name":"BN.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.2"},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"placement_prior":{"value":-5.215889930725098}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ece3","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.3"},"immune_escape":{"value":"0.5060716304521155"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.11385"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"immune_escape":{"value":"0.653690335850791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08339"},"placement_prior":{"value":-3.9134323596954346}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}}]},{"name":"NODE_0000503","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.74121356010437}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.74121356010437}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.221138954162598}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.97773551940918}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.7","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-11-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"immune_escape":{"value":"0.9193315170816834"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.5340599999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000504","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"BN.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000505","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"immune_escape":{"value":"0.7470314258752732"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.1331"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"immune_escape":{"value":"0.7815531080803261"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.31233"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000507","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":13},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000508","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}},{"name":"BN.1.4.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000509","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.136174201965332}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-11-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.220160484313965}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000510","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"immune_escape":{"value":"0.7326886306518271"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.21326"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.6","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.4","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.8","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000511","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000512","node_attrs":{"div":31,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1.5","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"FR.1.3","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"NODE_0000513","node_attrs":{"div":35,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FR.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49798059463501}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-5.060053825378418}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":28,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"immune_escape":{"value":"1.0513083167390975"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.16291"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DS.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.12","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.856032848358154}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.576071739196777}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.3","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}},{"name":"EJ.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EJ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}}]},{"name":"internal_f14e","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.13","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-08-06"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.11","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.5","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-02"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-3.791740894317627}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BN.1.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}}]}]}]}]}]},{"name":"NODE_0000520","node_attrs":{"div":19,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.306234359741211}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-4.306234359741211}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.3"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-5.302023887634277}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.5","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.5"},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"placement_prior":{"value":-5.031914234161377}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.6"},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"internal_42af","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.044631481170654}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2"},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"placement_prior":{"value":-5.044631481170654}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"immune_escape":{"value":"0.5272935807019111"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.26994"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"internal_6120","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.549932479858398}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.78817"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-08-30"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-03"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000525","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458258628845215}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}},{"name":"BM.1.1.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}}]},{"name":"internal_f6c6","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.43724"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":25,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000528","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-14"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"immune_escape":{"value":"0.9457248359372292"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.87567"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.26216459274292}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000529","node_attrs":{"div":28,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.3572282791137695}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CJ.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000530","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000531","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-06"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}},{"name":"CV.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000532","node_attrs":{"div":27,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000533","node_attrs":{"div":29,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000534","node_attrs":{"div":35,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000535","node_attrs":{"div":39,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-09-26"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EP.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":20,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4"},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"placement_prior":{"value":-5.539876937866211}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":21,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":22,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000539","node_attrs":{"div":23,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852804660797119}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":26,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.0219999999999998"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":24,"clade_membership":{"value":"22D"},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_display":{"value":"22D (BA.2.75)"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22D"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"immune_escape":{"value":"0.7685109779549473"},"clade_display":{"value":"22D (BA.2.75)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22D"},"ace2_binding":{"value":"0.36891999999999997"},"placement_prior":{"value":-5.968311786651611}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000542","node_attrs":{"div":25,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.05629825592041}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000543","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":69},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":1},"Nextclade_pango":{"value":"CH.1.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"immune_escape":{"value":"0.9441222497200389"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:59-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.08511000000000003"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000544","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000545","node_attrs":{"div":31,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000546","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.265082359313965}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.24","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.29","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-01-07"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000547","node_attrs":{"div":29,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"NODE_0000548","node_attrs":{"div":31,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"DV.3","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56d62e69","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-05-06"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":73},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":34,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-25"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000555","node_attrs":{"div":40,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613063812256}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-06-26"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000556","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":47,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":43,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":44,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.2","node_attrs":{"div":48,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}},{"name":"JV.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":81},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}}]}]},{"name":"NODE_0000559","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":49,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KG.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000560","node_attrs":{"div":41,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.3","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-10-15"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-09-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.9","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":80},"designation_date":{"value":"2023-12-17"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DV.7.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000561","node_attrs":{"div":26,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000562","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000563","node_attrs":{"div":27,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}},{"name":"GP.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"GP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0000564","node_attrs":{"div":27,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462465286255}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.6","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.377431869506836}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.8","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000565","node_attrs":{"div":30,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":71},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-04-21"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000566","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":68},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.547108173370361}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":70},"designation_date":{"value":"2023-03-29"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000567","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000568","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":34},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":45,"totalAminoacidDeletions":{"value":34},"totalAminoacidSubstitutions":{"value":79},"designation_date":{"value":"2023-12-01"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":28,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":69},"designation_date":{"value":"2023-03-20"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000570","node_attrs":{"div":32,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":72},"designation_date":{"value":"2023-03-31"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":35,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-04-22"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}},{"name":"FK.1.2.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":78},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}}]},{"name":"NODE_0000572","node_attrs":{"div":33,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":36,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":36,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}}]},{"name":"NODE_0000574","node_attrs":{"div":37,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":74},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.770232200622559}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":38,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":38,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-04-13"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.1","node_attrs":{"div":42,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":77},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"immune_escape":{"value":"0.9815994835819151"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.16085999999999998"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}},{"name":"FK.1.1.2","node_attrs":{"div":40,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":40,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T238-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-05-24"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-238T","T241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":41,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000577","node_attrs":{"div":43,"clade_membership":{"value":"23C"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_display":{"value":"23C (CH.1.1)"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":43,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":75},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.664889335632324}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":12},"totalAminoacidSubstitutions":{"value":76},"designation_date":{"value":"2023-09-04"},"clade_membership":{"value":"23C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000578","node_attrs":{"div":50,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.659756660461426}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":50,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-08-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.659756660461426}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":51,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.4"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.5"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000579","node_attrs":{"div":52,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":52,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}},{"name":"LV.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.6.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}}]},{"name":"NODE_0000580","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-06-13"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.7"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000581","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.7.1"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"immune_escape":{"value":"1.6738025507980547"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.12555999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000582","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":82},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000583","node_attrs":{"div":56,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-03-05"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2"},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.15919"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000584","node_attrs":{"div":60,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-03-20"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}},{"name":"JQ.2.1.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"23I"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JQ.2.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000585","node_attrs":{"div":52,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.786079406738281}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.4"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.519155979156494}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000586","node_attrs":{"div":53,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.825652837753296}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":53,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2023-09-05"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-3.825652837753296}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.12"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.16","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.16"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.14","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.14"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.15","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.15"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.17","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.17"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.18","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.18"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.19","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.19"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.6","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.6"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.7"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.8","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.8"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"JN.9","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.9"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"NODE_0000587","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.11"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}},{"name":"JN.11.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}}]},{"name":"NODE_0000588","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":83},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.13"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-03-06"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-6.398621082305908}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000589","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-14"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.5"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.6465599999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000590","node_attrs":{"div":55,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-11-17"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000591","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"ORF1a":["P892S"]},"labels":{"aa":"N: H300Y; ORF1a: P892S"}},"children":[{"name":"JN.3.2.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.3.2","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-16"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000592","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":54,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-10-12"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":57,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":56,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":85},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000593","node_attrs":{"div":58,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-26"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.2.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000594","node_attrs":{"div":54,"clade_membership":{"value":"23I"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_display":{"value":"23I (BA.2.86)"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.369668006896973}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":55,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":84},"designation_date":{"value":"2023-11-21"},"clade_membership":{"value":"23I"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.10"},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"placement_prior":{"value":-4.502495765686035}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000595","node_attrs":{"div":58,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.788806915283203}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":58,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2023-09-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-2.788806915283203}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.12","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-21"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.26806999999999986"},"placement_prior":{"value":-5.217971324920654}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.10","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.4131927490234375}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.17","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9045615196228027}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.063985347747803}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.875726699829102}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.6741979122161865}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.28","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.40299129486084}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}}},{"name":"JN.1.3","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2023-12-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.494213581085205}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9726524353027344}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.493702411651611}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.403775691986084}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.0336198806762695}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.45","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.297048091888428}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.46","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.232478618621826}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.5","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.8044490814208984}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.11747407913208}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.342803478240967}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.61","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"immune_escape":{"value":"1.496607246855186"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.93036"},"placement_prior":{"value":-4.427524089813232}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.66","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"JN.1.67","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.554509162902832}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}}},{"name":"internal_67e01226","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.108648300170898}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.108648300170898}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.2.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.971957206726074}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240912437438965}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.23.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-02-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"placement_prior":{"value":-5.240912437438965}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013584613800049}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.24.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.322965145111084}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.013584613800049}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.161866188049316}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.161866188049316}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.32.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.261717796325684}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.844590663909912}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.844590663909912}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.38.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}}]},{"name":"internal_01602336","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.392269611358643}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.392269611358643}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.43.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741122722625732}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.741122722625732}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.44.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.84599494934082}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5013346672058105}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.54.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"immune_escape":{"value":"1.532734695870142"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.05681999999999991"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}},{"name":"JN.1.54","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.5013346672058105}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.906701564788818}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.56.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"immune_escape":{"value":"1.5395016697354735"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.7602899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-31"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.906701564788818}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803345680236816}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.803345680236816}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.59.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":8.507},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235188961029053}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.235188961029053}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.493972301483154}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000607","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.167296886444092}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.167296886444092}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.63.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.744463920593262}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.04854154586792}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.04854154586792}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.250698566436768}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.250698566436768}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.39476203918457}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.39476203918457}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4552364349365234}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332151889801025}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.332151889801025}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.36.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.063086032867432}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005958557128906}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.005958557128906}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.993703842163086}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.47.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.40569543838501}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.40569543838501}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082462787628174}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.082462787628174}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.513469696044922}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.513469696044922}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.825034141540527}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.55.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"internal_b7e309e8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.62","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","G23604A"],"S":["V62F","R681H"]},"labels":{"aa":"S: V62F, R681H","spike_mutations":"V62F, R681H"}}},{"name":"NODE_0000620","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{"nuc":["G4162A","G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9000465869903564}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9000465869903564}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.853470325469971}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.175985336303711}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.564305782318115}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.39.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9655609130859375}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.9655609130859375}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.303173065185547}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.439826011657715}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.217770576477051}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-18"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ME.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.27215999999999985"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894876480102539}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.894876480102539}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.83441162109375}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.83441162109375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000629","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2595099999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}},{"name":"LN.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.765995025634766}},"branch_attrs":{"mutations":{}}},{"name":"MF.2","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}},{"name":"MF.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000632","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24034T","C24370T","A29700G"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000633","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"immune_escape":{"value":"1.3745641202332524"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.9318500000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000634","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000635","node_attrs":{"div":68,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_21507594","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343790531158447}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.343790531158447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000637","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548246383666992}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.548246383666992}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.693402290344238}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.1249308586120605}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KU.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566922187805176}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":86},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"NODE_0000642","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000644","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000645","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4388251304626465}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000646","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250442504883}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.617250442504883}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.769711017608643}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.769711017608643}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753198623657227}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"NODE_0000650","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-08-20"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":96},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}},{"name":"LU.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.396686553955078}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.772514820098877}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.772514820098877}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.49.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.318779945373535}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_d6241d6f","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.515067100524902}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000655","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000656","node_attrs":{"div":68,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.30217999999999995"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000657","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309075355529785}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.409302234649658}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.309075355529785}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.224586486816406}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.872847080230713}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.872847080230713}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.486630439758301}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.534714698791504}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.534714698791504}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.343343257904053}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.343343257904053}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917464256286621}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.917464256286621}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-07-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2406325340271}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.9638495445251465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000664","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"placement_prior":{"value":-5.469202041625977}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.105811595916748}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.06282901763916}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KS.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.098007678985596}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.57.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.57.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}}]},{"name":"internal_dd754174","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.08313"},"placement_prior":{"value":-4.566637992858887}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.69068717956543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.287435054779053}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.7","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.175660133361816}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.9","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000671","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000672","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.04395"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.95433"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}},{"name":"LK.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-07-03"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.7120614051818848}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.7120614051818848}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.776768207550049}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.74375057220459}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.159214973449707}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000677","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.8164632320404053}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.098134517669678}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.037208080291748}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{}}},{"name":"KV.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}},{"name":"KV.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.782661437988281}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.782661437988281}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000681","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769671440124512}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.769671440124512}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-5.145885944366455}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000682","node_attrs":{"div":67,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LE.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.528179883956909}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2023-11-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-3.528179883956909}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000684","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.735454082489014}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.642605304718018}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-5.642605304718018}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.3354692459106445}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.97365140914917}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.97365140914917}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.621727466583252}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-04-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KZ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000689","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227312564849854}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2023-12-02"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.8855814933776855}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-02-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.850395679473877}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000690","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.5","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"KR.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000691","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":11.111},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000692","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.076401710510254}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1.3","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"NODE_0000693","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0563764572143555}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-09"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.0563764572143555}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.607524394989014}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1424689292907715}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.1424689292907715}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.6","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.8","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000696","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-24"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000697","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.662585735321045}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}},{"name":"LB.1.2.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.979491710662842}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-13"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000699","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883163452148}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.111883163452148}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.472174167633057}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000701","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-01"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.068140029907227}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.347520351409912}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000702","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.716819763183594}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.0124382972717285}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_dc847259","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.415851593017578}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.415851593017578}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}},"children":[{"name":"LA.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.685051441192627}},"branch_attrs":{"mutations":{"nuc":["T22599C"],"S":["I346T"]},"labels":{"aa":"S: I346T","spike_mutations":"I346T"}}},{"name":"LA.2","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.04741999999999978"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000706","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.079800128936768}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.079800128936768}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":50.174},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"immune_escape":{"value":"1.817229820305529"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.21767999999999987"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-7.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}},{"name":"LF.3.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000712","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671465873718262}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.671465873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000713","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-27"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"3-4 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.9.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000714","node_attrs":{"div":65,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000715","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}},{"name":"LF.8.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":59,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.091001987457275}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":59,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-02-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.091001987457275}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958034038543701}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.958034038543701}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","K182-","Q183-","G184-","N185-","F186-","N188Q","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, K182-, Q183-, G184-, N185-, F186-, N188Q, L189A","spike_mutations":"Y28H, K182-, Q183-, G184-, N185-, F186-, N188Q, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688790798187256}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.688790798187256}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.81335973739624}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-4.81335973739624}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-4.7956719398498535}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MA.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":11.111},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3926199999999998"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994C","C21998-","A21999-","C22000-","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451901912689209}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-14"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-5.451901912689209}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.520982265472412}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}},{"name":"LQ.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000725","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.054087162017822}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":63,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":61,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172401428222656}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":61,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.172401428222656}},"branch_attrs":{"mutations":{}}},{"name":"LY.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"LY.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"NODE_0000728","node_attrs":{"div":62,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":88},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":66,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}},{"name":"LZ.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000730","node_attrs":{"div":64,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-12"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}},{"name":"LZ.2.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-09-05"},"clade_membership":{"value":"24A"},"designation_recency":{"value":"2-3 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LZ.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":60,"clade_membership":{"value":"24A"},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_display":{"value":"24A (JN.1)"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":60,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":87},"designation_date":{"value":"2024-01-11"},"clade_membership":{"value":"24A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":62,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.329638481140137}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":62,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-01-22"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.329638481140137}},"branch_attrs":{"mutations":{}}},{"name":"KP.5","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.512091159820557}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.6","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.04741999999999978"},"placement_prior":{"value":-6.009568691253662}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":89},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000734","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.230648040771484}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.3","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.4.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"immune_escape":{"value":"1.7741516492587035"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.27333999999999997"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}},{"name":"KP.4.2.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.4.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]}]}]},{"name":"NODE_0000738","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.700614929199219}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-02-22"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.700614929199219}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-03-25"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.919792890548706}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.919792890548706}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.4","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"LP.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"NODE_0000743","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928211212158}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.200928211212158}},"branch_attrs":{"mutations":{}}},{"name":"internal_bfd296bd","node_attrs":{"div":67,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000745","node_attrs":{"div":63,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.814105272293091}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.814105272293091}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.616664409637451}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.439517021179199}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.12","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.19","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":1.562},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.083328723907471}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.20.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.0966644287109375}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":65,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-04-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"internal_1e4c8e87","node_attrs":{"div":66,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.2861931324005127}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"immune_escape":{"value":"1.7908990401504723"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"-0.40119000000000016"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.4","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3312699999999998"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.939983367919922}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.632704257965088}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000750","node_attrs":{"div":67,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.1148176193237305}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":96},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000751","node_attrs":{"div":64,"clade_membership":{"value":"24B"},"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_display":{"value":"24B (JN.1.11.1)"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.9114367961883545}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-05-17"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.21942999999999988"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.16","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.532774448394775}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-07"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.196527481079102}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.17","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.2","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-03-19"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24B"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-6.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.6","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-4.883235454559326}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.7","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-15"},"clade_membership":{"value":"24B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000752","node_attrs":{"div":63,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9876158237457275}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":63,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-03-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9876158237457275}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.6","node_attrs":{"div":64,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.772136211395264}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.3.5","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"internal_123a0013","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094733715057373}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.094733715057373}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-10"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"immune_escape":{"value":"1.5554650921238282"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15242"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"NODE_0000755","node_attrs":{"div":68,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":67,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ML.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"ML.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ML.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9918503761291504}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2.1","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-29"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-30"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9918503761291504}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.093895435333252}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-09"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.350859642028809}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":69,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":70,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":94},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"LW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":65,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":65,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-05-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-06-17"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000761","node_attrs":{"div":68,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":71,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-16"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.174},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000763","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":66,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":90},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.1","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":73,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":95},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24C"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.694},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"immune_escape":{"value":"1.7206397516519647"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.11924"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}},{"name":"MK.2","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-07-12"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":66,"clade_membership":{"value":"24C"},"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_display":{"value":"24C (KP.3)"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323394775391}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-04"},"clade_membership":{"value":"24C"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000765","node_attrs":{"div":67,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":67,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-05-28"},"clade_membership":{"value":"24E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.2025511264801025}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-06-29"},"clade_membership":{"value":"24E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.857026100158691}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.15","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.3","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.5","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.4","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.8321967124938965}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.6","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.7","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"immune_escape":{"value":"1.5369762101413171"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.3172000000000001"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000766","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"MC.11","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000767","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.422041893005371}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":70,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":92},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":69,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-08"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":68,"clade_membership":{"value":"24E"},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_display":{"value":"24E (KP.3.1.1)"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":68,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":91},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":72,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":93},"designation_date":{"value":"2024-08-15"},"clade_membership":{"value":"24E"},"designation_recency":{"value":"4-8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"MC.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":4,"clade_membership":{"value":"21L"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_display":{"value":"21L (BA.2)"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.637859344482422}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000771","node_attrs":{"div":5,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.49234676361084}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":5,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.49234676361084}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":6,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.325173854827881}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":6,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.325173854827881}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0000773","node_attrs":{"div":7,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.9142110347747803}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.3","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.5","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-09"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000774","node_attrs":{"div":10,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.2","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.2"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-05"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.3","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":18},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.71883"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.4","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000775","node_attrs":{"div":11,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.8603827953338623}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":12,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.6.5.1"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.66094"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"NODE_0000776","node_attrs":{"div":7,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.6947638988494873}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":7,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.6947638988494873}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-08"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.3","node_attrs":{"div":10,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.5","node_attrs":{"div":9,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.6","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0240254402160645}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.4","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.100764274597168}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.8","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-29"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.9","node_attrs":{"div":8,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-27"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.872378349304199}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000777","node_attrs":{"div":8,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-06-09"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.477802276611328}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000778","node_attrs":{"div":9,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.11"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0000779","node_attrs":{"div":11,"clade_membership":{"value":"22A"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_display":{"value":"22A (BA.4)"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":11,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.10"},"immune_escape":{"value":"0.5308081831240151"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.67074"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22A"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CS.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.4.1.10.1"},"immune_escape":{"value":"0.7561969850799493"},"clade_display":{"value":"22A (BA.4)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22A"},"ace2_binding":{"value":"0.5702799999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0000780","node_attrs":{"div":13,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155839443206787}},"branch_attrs":{"mutations":{"nuc":["C1931A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF1a":["Q556K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF1a: Q556K; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-04-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.9592297077178955}},"branch_attrs":{"mutations":{"nuc":["A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}}},{"name":"BA.5.3","node_attrs":{"div":13,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.155839443206787}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":36},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:72-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7818877696990967}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.1","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.121390342712402}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"BA.5.3.5","node_attrs":{"div":16,"totalAminoacidDeletions":{"value":36},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"placement_prior":{"value":-3.2392046451568604}},"branch_attrs":{"mutations":{"nuc":["T1570C","A1931C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["K556Q","T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: K556Q, T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"BE.2","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.800013303756714}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T","G28681T"],"N":["E136D"],"ORF1a":["T882I"]},"labels":{"aa":"N: E136D; ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2200896739959717}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","G28681T","C28724T"],"N":["E136D","P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: E136D, P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":14,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.121390342712402}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"NODE_0000781","node_attrs":{"div":14,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.80837082862854}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.920682191848755}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.3.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.250558853149414}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}}]},{"name":"NODE_0000782","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9044742584228516}},"branch_attrs":{"mutations":{"nuc":["A1931C","A6551C","G29032A"],"ORF1a":["K556Q","M2096L"]},"labels":{"aa":"ORF1a: K556Q, M2096L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}},{"name":"BA.5.8","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3900210857391357}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}}]},{"name":"NODE_0000783","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.437628269195557}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A","G28681T"],"N":["E136D"],"S":["K444T","N460K"]},"labels":{"aa":"N: E136D; S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.10"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.9"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.6684834957122803}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0000784","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2901611328125}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","G28681T","T28693C"],"N":["E136D"],"ORF1a":["M85-"]},"labels":{"aa":"N: E136D; ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.7371015548706055}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":95},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.394863128662109}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000785","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9449503421783447}},"branch_attrs":{"mutations":{"nuc":["A1931C","C21789T"],"ORF1a":["K556Q"],"S":["T76I"]},"labels":{"aa":"ORF1a: K556Q; S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.243032455444336}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"BA.5.5","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.9449503421783447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000786","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891446352005005}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}},{"name":"BA.5.5.1","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.5.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-3.5124127864837646}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}}]}]},{"name":"NODE_0000787","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.720151662826538}},"branch_attrs":{"mutations":{"nuc":["G28681T","T28693C"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BE.11","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.007559776306152}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"BE.12","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"NODE_0000788","node_attrs":{"div":16,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.232304573059082}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":95},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.13"},"immune_escape":{"value":"0.5088823627149919"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5231200000000001"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":94},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":56.25},"partiallyAliased":{"value":"BA.5.3.1.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":1},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T","G28681T"],"N":["E136D"],"ORF1a":["T3308N"]},"labels":{"aa":"N: E136D; ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000790","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2813496589660645}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0000791","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"placement_prior":{"value":-3.919694185256958}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0000793","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"CQ.1.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.685410499572754}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]}]}]}]}]},{"name":"NODE_0000794","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075937032699585}},"branch_attrs":{"mutations":{"nuc":["A1931C","T4906C","C17402T","T18957C","C21077T"],"ORF1a":["K556Q"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1a: K556Q; ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.075937032699585}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000795","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130266189575195}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.6.4","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5883099999999998"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}}]},{"name":"NODE_0000796","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3249030113220215}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.3249030113220215}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000797","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6570799999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0000798","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.291694164276123}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.391442775726318}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}},{"name":"BW.1.1.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BW.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}}]}]}]}]},{"name":"NODE_0000799","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2639026641845703}},"branch_attrs":{"mutations":{"nuc":["A1T","A1931C","T27438C","C29666T"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":50},"designation_date":{"value":"2022-05-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.2639026641845703}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.12"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.4234297275543213}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.14","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.14"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.9656171798706055}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.16"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9540679454803467}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.17"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.774606227874756}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2636609077453613}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.24"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3640329837799072}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.28","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.28"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.247698783874512}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.1495773792266846}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.30"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.902099132537842}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":20},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.34"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0658464431762695}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A21999-","C22000-","A22001-","A22002-","A22003-","A22004-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["H146-","K147-","N148H","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: H146-, K147-, N148H, P1162S","spike_mutations":"H146-, K147-, N148H, P1162S"}}},{"name":"BA.5.1.6","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.541465997695923}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.4","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.7","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.7"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8861465454101562}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.5","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.146693468093872}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.8","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.632486343383789}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0000800","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.10.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9345104694366455}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.15"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.15.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-3.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0000802","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2127861976623535}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2127861976623535}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.22.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","T21994C","T21995-","A21996-","C21997-","C21998-","A21999-","C22000-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0000803","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.26"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.460143089294434}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.26.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3030779361724854}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.38"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198533058166504}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.35"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.198533058166504}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.35.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000806","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415742874145508}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.33"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.415742874145508}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.33.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8465638160705566}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8465638160705566}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.115744113922119}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.23.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.33618688583374}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0000809","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.429936408996582}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.18"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000810","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069718837738037}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.069718837738037}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.21.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_b005","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.521807909011841}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.27"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.160993576049805}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0000814","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}},{"name":"CL.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CL.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]}]}]}]},{"name":"internal_2d50","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806924343109131}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.806924343109131}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.112699508666992}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-5.112699508666992}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000817","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.253764629364014}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-12-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"DJ.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"NODE_0000818","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DJ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"NODE_0000819","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.733210325241089}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.0830414295196533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-09-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.0468878746032715}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-01-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.32"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.180698871612549}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0000820","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1143693923950195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-07"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.20"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.530765533447266}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.37","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.37"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}},{"name":"BA.5.1.36","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.1.36"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}}]}]}]},{"name":"NODE_0000821","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024465799331665}},"branch_attrs":{"mutations":{"nuc":["G16935A","G28681T"],"N":["E136D"],"ORF1b":["M1156I"]},"labels":{"aa":"N: E136D; ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":15,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-05-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.024465799331665}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":17},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0000822","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.295308589935303}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.295308589935303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000823","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"immune_escape":{"value":"0.8224959014481948"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.49383999999999995"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0000824","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0000825","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0000826","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708206176757812}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.7708206176757812}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000827","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000828","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036677837371826}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-08-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.036677837371826}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"immune_escape":{"value":"0.5680790723509552"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45205000000000006"},"placement_prior":{"value":-4.677975654602051}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0000829","node_attrs":{"div":21,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3825254440307617}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-09-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.3825254440307617}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.3848819732666016}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4368510246276855}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.19","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"immune_escape":{"value":"0.7257362514460642"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6127800000000001"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.17","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-4.728248119354248}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"immune_escape":{"value":"0.8308113969466171"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5446"},"placement_prior":{"value":-4.456897258758545}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6570799999999999"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.423923492431641}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.428438186645508}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.936223268508911}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.945977210998535}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.5","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4588370323181152}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.7","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.915694236755371}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.9","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.6576948165893555}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000830","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.761805534362793}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-26"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0000831","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000832","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000833","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865875720977783}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.865875720977783}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000834","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009591579437256}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.068519592285156}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.15.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"internal_56b3","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.25.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000837","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.709598541259766}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.709598541259766}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000838","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.26.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"NODE_0000839","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4316978454589844}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}},{"name":"BQ.1.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.912674903869629}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0000841","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"immune_escape":{"value":"0.6853534127590314"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6353800000000001"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.217254161834717}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.194500923156738}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EC.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.4688432216644287}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.687568426132202}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"internal_dbfb","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"immune_escape":{"value":"0.6925976779449897"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5174000000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000846","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":35,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"immune_escape":{"value":"0.9874397743924017"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66664"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0000847","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":19},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-04-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":39,"totalAminoacidDeletions":{"value":31},"totalAminoacidSubstitutions":{"value":67},"designation_date":{"value":"2023-08-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"JH.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"immune_escape":{"value":"1.0821590912755812"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7a:83-122"},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6059300000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":22,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7632393836975098}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.5457186698913574}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.23","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.451982259750366}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.056915760040283}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"placement_prior":{"value":-4.627330780029297}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"BQ.1.8","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"internal_9a91","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0000851","node_attrs":{"div":23,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.3905270099639893}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-09-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-2.3905270099639893}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-3.889237880706787}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-4.534395694732666}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.17","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.146517276763916}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.16","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.6093573570251465}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.19","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.224153995513916}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.530550003051758}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9906511306762695}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7449699999999998"},"placement_prior":{"value":-4.06502103805542}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-01"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"immune_escape":{"value":"0.8728938682420008"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5921799999999998"},"placement_prior":{"value":-4.8411335945129395}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"placement_prior":{"value":-4.593058109283447}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8225154876708984}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.34","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.37","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.312097549438477}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.36","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.200605392456055}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.227291584014893}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.40","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9314393997192383}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.41","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.904665470123291}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.049081802368164}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.45","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6982169151306152}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.47","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.249353408813477}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.385838985443115}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.995295286178589}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.85848331451416}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.57","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.359898090362549}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.56","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.529128551483154}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.58","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.37760591506958}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.60","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.216671466827393}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.973445177078247}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.64"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.916758060455322}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.66"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.271931171417236}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.63","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.37089204788208}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.67","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.67"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.056057929992676}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.68"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.0179009437561035}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.69","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.69"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6361196041107178}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.70"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.841104507446289}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.73"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.76","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.76"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.239201068878174}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.75","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.75"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"immune_escape":{"value":"1.051732686328446"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"-0.04867000000000007"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.77","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.77"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.662373065948486}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.7189483642578125}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.2001824378967285}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.2001824378967285}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":25},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.70602"},"placement_prior":{"value":-5.588834762573242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0000853","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9955062866210938}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9955062866210938}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"placement_prior":{"value":-4.9605021476745605}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0000854","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09937858581543}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-19"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.09937858581543}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0000855","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.933582067489624}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.7809853553771973}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-02"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.529773235321045}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000856","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500675678253174}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-06-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.79"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-14"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-16"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ET.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.596988677978516}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0000858","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.477259159088135}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.477259159088135}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ES.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.674633979797363}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0000859","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848482131958008}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.848482131958008}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-11-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.74371"},"placement_prior":{"value":-4.994816303253174}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.450014591217041}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.450014591217041}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FC.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.90073823928833}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000861","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.212815284729004}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-12-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"immune_escape":{"value":"0.9105813557217661"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.66913"},"placement_prior":{"value":-4.2420334815979}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8017332553863525}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.8017332553863525}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6774299999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0000863","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9086992740631104}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.9086992740631104}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.79539680480957}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.999442100524902}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000864","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109678268432617}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.109678268432617}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000865","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.950040817260742}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ER.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-03-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.950040817260742}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000866","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.677121162414551}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.677121162414551}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.548750877380371}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-4.493981838226318}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000867","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.694068908691406}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000868","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-26"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000869","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6486151218414307}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.49","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.766873359680176}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.48","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.388899803161621}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.78","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-06-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.78"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"NODE_0000870","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131350517272949}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.131350517272949}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.47806978225708}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EA.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"immune_escape":{"value":"0.880706782961692"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.34834999999999994"},"placement_prior":{"value":-4.918065547943115}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_1117","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.497538089752197}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.497538089752197}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FM.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-04-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FM.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.829411506652832}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.498441696166992}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.498441696166992}},"branch_attrs":{"mutations":{}}},{"name":"ED.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.188002586364746}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"ED.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.897397041320801}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0000873","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.166533946990967}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.000680923461914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0000874","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.433859825134277}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-12-04"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.433859825134277}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EH.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.000488758087158}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-12-31"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.000488758087158}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.651236534118652}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DT.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.224048137664795}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"NODE_0000876","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{"nuc":["T7633C","C22314T","A24129G"],"S":["P251L","N856S"]},"labels":{"aa":"S: P251L, N856S","spike_mutations":"P251L, N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.983821868896484}},"branch_attrs":{"mutations":{}}},{"name":"EW.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}},{"name":"EW.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EW.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1165571212768555}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":25,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302682876586914}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0000879","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"NODE_0000880","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.684224605560303}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.684224605560303}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-05"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000881","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.281740188598633}},"branch_attrs":{"mutations":{"nuc":["C22314T","T23716C","A28834G"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0000882","node_attrs":{"div":30,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-01-27"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":65},"designation_date":{"value":"2023-04-17"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"FQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000883","node_attrs":{"div":31,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-03"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":33,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4922783374786377}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.4922783374786377}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.184210777282715}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.1315507888793945}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.840254783630371}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"EE.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.185059070587158}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EE.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.52209997177124}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}}]},{"name":"NODE_0000885","node_attrs":{"div":24,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.140864372253418}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.140864372253418}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.2411675453186035}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"EF.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.071333885192871}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"internal_bc60","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.180258750915527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000887","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138623237609863}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.22083044052124}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127103328704834}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.127103328704834}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000889","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.656729698181152}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-03-21"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"EY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0000890","node_attrs":{"div":26,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.802454948425293}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-3.6995480060577393}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0000891","node_attrs":{"div":27,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-7.322900772094727}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"DN.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-05-07"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.507904529571533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000892","node_attrs":{"div":28,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858262062072754}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2022-12-22"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.858262062072754}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000893","node_attrs":{"div":29,"clade_membership":{"value":"22E"},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_display":{"value":"22E (BQ.1)"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":63},"designation_date":{"value":"2022-12-25"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.1","node_attrs":{"div":34,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":66},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"immune_escape":{"value":"0.8990816968865659"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"2.05606"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"immune_escape":{"value":"0.8744814686582322"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.6722600000000001"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.2","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":64},"designation_date":{"value":"2023-01-30"},"clade_membership":{"value":"22E"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DN.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"immune_escape":{"value":"0.8771384492554943"},"clade_display":{"value":"22E (BQ.1)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22E"},"ace2_binding":{"value":"0.5626099999999999"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}}]}]}]}]}]}]}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":15,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1493752002716064}},"branch_attrs":{"mutations":{"nuc":["C1627T","A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.11","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":22},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7922699451446533}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000896","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000897","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.509319305419922}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0000898","node_attrs":{"div":17,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6984124183654785}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":17,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-05-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6984124183654785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000899","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6816165447235107}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":18,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.6816165447235107}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5279"},"placement_prior":{"value":-3.9799368381500244}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.17","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.17"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.486154556274414}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.19","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.18"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.092382907867432}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.30","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.30"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.33"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6034899999999999"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.5524344444274902}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.6"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9146859645843506}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.4910569190979004}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0000900","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0925703048706055}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BF.14","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.14"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-3.080409288406372}},"branch_attrs":{"mutations":{"nuc":["C16726T"],"ORF1b":["H1087Y"]},"labels":{"aa":"ORF1b: H1087Y"}}},{"name":"BF.35","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.35"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I"}}}]},{"name":"NODE_0000901","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.864605188369751}},"branch_attrs":{"mutations":{"nuc":["T6979G","C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.1568257808685303}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.27"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3811821937561035}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0000902","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278052806854248}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":51},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.278052806854248}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.31.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.006015777587891}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.39"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.006015777587891}},"branch_attrs":{"mutations":{}}},{"name":"BF.39.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.39.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"immune_escape":{"value":"0.5959379308450252"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.33263"},"placement_prior":{"value":-5.380832195281982}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}}]},{"name":"internal_a7a7","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.141679286956787}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.41"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.141679286956787}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.41.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000905","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5755422115325928}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5755422115325928}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.462975025177002}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0000906","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.166617393493652}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}},{"name":"BF.11.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.11.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.292903900146484}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}}]}]},{"name":"NODE_0000907","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.768697738647461}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7897300720214844}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.28"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.266979217529297}},"branch_attrs":{"mutations":{"nuc":["A396T"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.36","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.36"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.9","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.462023973464966}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0000908","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4318153858184814}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.4318153858184814}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0000909","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.138409376144409}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.10.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"immune_escape":{"value":"0.563032084337257"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.3218"},"placement_prior":{"value":-4.989957332611084}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}},{"name":"BF.10","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.138409376144409}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000910","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1209073066711426}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.15"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.382307052612305}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.20"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.54063081741333}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0000911","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.4587743282318115}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.16"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.25"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.29"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.740654468536377}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-08"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.34"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685426235198975}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.23"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337315082550049}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.3.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.48889999999999995"},"placement_prior":{"value":-4.257188320159912}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}},{"name":"BF.3","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.337315082550049}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000914","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.661623001098633}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.24"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.6700644493103027}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0000915","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160372257232666}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.160372257232666}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000916","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7555065155029297}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-03-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.592723846435547}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0000917","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0702483654022217}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.266252517700195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000918","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.60558819770813}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0000919","node_attrs":{"div":27,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.3","node_attrs":{"div":46,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":62},"designation_date":{"value":"2023-02-08"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}},{"name":"BF.5.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-27"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.5.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-4.553523063659668}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]}]}]}]}]}]}]},{"name":"NODE_0000920","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.604146718978882}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-04-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.42"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.3972127437591553}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.26"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.32"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.259809494018555}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.37"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-4.417163372039795}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.40"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.287785530090332}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"NODE_0000922","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238605976104736}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.238605976104736}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.38.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0000923","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-07-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-2.8403658866882324}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.10","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.541252613067627}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.11","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.12","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.68569278717041}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.15","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.15"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5383856296539307}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.17"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.512576580047607}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.21","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6393200000000001"},"placement_prior":{"value":-4.518761157989502}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.23","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.26","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.24","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.6","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.8","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.2593913078308105}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0000924","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.16.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}},{"name":"BF.7.16","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000925","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.246763229370117}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.19.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0000926","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.5.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.5.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}}]},{"name":"NODE_0000927","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.2","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.13.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}}]},{"name":"NODE_0000928","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-10-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-03-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000929","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}},{"name":"BF.7.4.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.4.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.3122615814208984}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}}]}]},{"name":"NODE_0000930","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0000931","node_attrs":{"div":28,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":61},"designation_date":{"value":"2023-01-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.5","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"BF.7.14.4","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"NODE_0000932","node_attrs":{"div":29,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":60},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BF.7.14.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0000933","node_attrs":{"div":18,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.632067918777466}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.23"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.23"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-3.815178394317627}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":19,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-07-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.182595252990723}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.40"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.40"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-07-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.5"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.9"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.9"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-2.992319107055664}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0000934","node_attrs":{"div":19,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2570536136627197}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.10"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.10"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.743116855621338}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":21,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.628093719482422}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0000935","node_attrs":{"div":20,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.856088161468506}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":20,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.26"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.856088161468506}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.26.1"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]},{"name":"NODE_0000936","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190079689025879}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.22"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.22"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.498506784439087}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.28","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.28"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.28"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.2396790981292725}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.29","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.29"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.29"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.531044960021973}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.45","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.45"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.45"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5131699999999999"},"placement_prior":{"value":-4.9987969398498535}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.52"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.52"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.161417007446289}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.55"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.55"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9991252422332764}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.59"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.59"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.2738494873046875}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0000937","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.982447624206543}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.33"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.982447624206543}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CE.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.33.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"placement_prior":{"value":-4.402839660644531}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0000938","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.680324077606201}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.680324077606201}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.49.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]}]},{"name":"ORF1b1050_internal","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.190079689025879}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.12"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.12"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.3988919258117676}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.13"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.13"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.693638563156128}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.14"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.14"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.19"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.19"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7940964698791504}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.30"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.30"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-4.567533493041992}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.35","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.35"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.35"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.34","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.34"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.34"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.5116825103759766}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.37"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.37"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.46013069152832}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.39"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.39"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.42"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.42"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.43"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.43"},"immune_escape":{"value":"0.5413273873731987"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5642800000000001"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.44"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.44"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.2824883460998535}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.46","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.46"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.46"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.53"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.53"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.239425182342529}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.54"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.54"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.244055271148682}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.58","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.58"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.58"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-4.236813068389893}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.57","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.57"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.57"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"placement_prior":{"value":-3.7233779430389404}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.61","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.61"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.61"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.716227054595947}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.62","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.62"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.62"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.200314521789551}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.63"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.63"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.8","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.8"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.9480412006378174}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3595662117004395}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-26"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.11"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.11"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.32"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.32"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.365047454833984}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8121001720428467}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.27"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.8121001720428467}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CF.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.27.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.800676345825195}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_a10d","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.362414836883545}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.38"},"immune_escape":{"value":"0.30660604695253"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.56458"},"placement_prior":{"value":-4.362414836883545}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-03"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DA.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.38.1"},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"placement_prior":{"value":-5.474380016326904}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_1651","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1829705238342285}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.36"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.1829705238342285}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CT.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.36.1"},"immune_escape":{"value":"0.7208595659836455"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4564899999999999"},"placement_prior":{"value":-5.6722588539123535}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"NODE_0000944","node_attrs":{"div":21,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.41"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.41"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.726003646850586}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.56"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.56"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.040581703186035}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.329519748687744}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.47"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.329519748687744}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DQ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.47.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.49553108215332}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0000946","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.104440450668335}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.104440450668335}},"branch_attrs":{"mutations":{}}},{"name":"BV.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BV.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.279457092285156}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}},{"name":"BV.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BV.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.20.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}}]},{"name":"NODE_0000947","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.469841718673706}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2022-09-18"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.469841718673706}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CN.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21.1"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-12-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CN.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.21.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.597593307495117}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-06-24"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.597593307495117}},"branch_attrs":{"mutations":{}}},{"name":"BZ.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BZ.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3.2"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BZ.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BZ.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.3.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}}]},{"name":"internal_74ef","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.18593692779541}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.18593692779541}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CD.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31.1"},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"placement_prior":{"value":-5.559307098388672}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-30"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CD.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.31.2"},"immune_escape":{"value":"0.3253063676642168"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5594199999999998"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0000950","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064769744873047}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.51","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-02-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.51"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.51"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.50","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-01-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.50"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.50"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.740553379058838}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.60","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-02-12"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.60"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.60"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0000951","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.064578533172607}},"branch_attrs":{"mutations":{}}},{"name":"CY.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-01"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}},{"name":"CY.2","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.7.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}}]},{"name":"NODE_0000952","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-09-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"placement_prior":{"value":-4.205173015594482}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-15"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.2"},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-10-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BU.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.16.3"},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415544033050537}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-25"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-4.415544033050537}},"branch_attrs":{"mutations":{}}},{"name":"DB.3","node_attrs":{"div":37,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-02-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.3"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.1"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"placement_prior":{"value":-4.356486797332764}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-04"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DB.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.25.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"NODE_0000955","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-17"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.032562732696533}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"placement_prior":{"value":-4.993216037750244}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0000956","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.665064811706543}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.665064811706543}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000957","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36299991607666}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2022-11-05"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}},{"name":"CR.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.244806289672852}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.3","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2022-12-16"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CR.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0000958","node_attrs":{"div":25,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":52},"designation_date":{"value":"2023-01-06"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.4"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.705625534057617}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0000959","node_attrs":{"div":27,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-01-28"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-01-31"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}}]},{"name":"NODE_0000960","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8918910026550293}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.2"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2023-02-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DY.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.48.3"},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2084972858428955}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-08-21"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-3.2084972858428955}},"branch_attrs":{"mutations":{}}},{"name":"CP.4","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.4"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.631740093231201}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.3"},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.38661"},"placement_prior":{"value":-4.830904960632324}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.2"},"immune_escape":{"value":"0.5295255377787571"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6942999999999999"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.5","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.5"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.982548236846924}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":31,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-03-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.7"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.7"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.6","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.6"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.6"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.8859148025512695}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"internal_7ebe","node_attrs":{"div":26,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8.1","node_attrs":{"div":32,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2023-03-23"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.8.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}},{"name":"CP.8","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2023-03-19"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.8"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000963","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.436136245727539}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-4.436136245727539}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-13"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"placement_prior":{"value":-5.384421348571777}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.3","node_attrs":{"div":26,"totalAminoacidDeletions":{"value":16},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6003199999999999"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}},{"name":"CP.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-02"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CP.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"placement_prior":{"value":-5.319474697113037}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}}]}]},{"name":"NODE_0000964","node_attrs":{"div":22,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.071380138397217}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":22,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":53},"designation_date":{"value":"2022-09-22"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.071380138397217}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-11-14"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.241237163543701}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"NODE_0000965","node_attrs":{"div":23,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.080973148345947}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":23,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-11"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.080973148345947}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000966","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000864505767822}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-01-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.71883"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["R346T"]},"labels":{"aa":"ORF1a: S2797F; S: R346T","spike_mutations":"R346T"}}},{"name":"CK.1.3","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.3"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.711991310119629}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0000967","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.605682373046875}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C25614T"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CK.1.5","node_attrs":{"div":27,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.5"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.420897483825684}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}},{"name":"CK.1.4","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.4"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}}]},{"name":"NODE_0000968","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021930694580078}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24129G"],"S":["Y144-","N856S"]},"labels":{"aa":"S: Y144-, N856S","spike_mutations":"Y144-, N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":57},"designation_date":{"value":"2023-07-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":28,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":56},"designation_date":{"value":"2023-09-10"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.657632350921631}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CK.1.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":15},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-12-29"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.021930694580078}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_36cf","node_attrs":{"div":24,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.372078895568848}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":25,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":54},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2"},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"placement_prior":{"value":-4.5281758308410645}},"branch_attrs":{"mutations":{"nuc":["G22942T"],"S":["K460N"]},"labels":{"aa":"S: K460N","spike_mutations":"K460N"}}},{"name":"CK.2.1","node_attrs":{"div":24,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":55},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.372078895568848}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":29,"clade_membership":{"value":"22B"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_display":{"value":"22B (BA.5)"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":29,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":58},"designation_date":{"value":"2022-10-20"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-4.201340675354004}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":30,"totalAminoacidDeletions":{"value":14},"totalAminoacidSubstitutions":{"value":59},"designation_date":{"value":"2022-11-09"},"clade_membership":{"value":"22B"},"designation_recency":{"value":">8 weeks"},"qc.frameShifts.totalFrameShifts":{"value":0},"Nextclade_pango":{"value":"DG.1"},"clade_who":{"value":"Omicron"},"qc.overallScore":{"value":0.0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_nextstrain":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"placement_prior":{"value":-5.097590923309326}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEEIGALIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNALRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSRADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLRDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPFTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGSSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVIPTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLCAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDIGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEIL*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHSALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLITRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPALPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYQKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKEGNFKNLREFVFKNIDGYFKIYSKHTPINLERDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFHEVFNATTFASVYAWNRKRISNCVADYSVIYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKPSGNYNYLYRLFRKSKLKPFERDISTEIYQAGNKPCNGVAGSNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"GTTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTTGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTTGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAGAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGGTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCATTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTTTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTAGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCTTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTATTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTGGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCATTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTTTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAATCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGATATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGACACAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATTTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACTTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCAGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTTTCTGACGATGCTGTTGTGTGTTTTAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGACCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATACCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTATGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATACGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACGTACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCGGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAATTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAGGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTATAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGCCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGATGTTTATTACCAAAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAAGAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGAGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTCATGAAGTTTTTAACGCCACCACATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCATATATAATTTCGCACCATTTTTCGCTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTAATGAAGTCAGCCAAATCGCTCCAGGGCAAACTGGAAATATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAAGCTTGATTCTAAGCCTAGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAAGCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAACAAACCTTGTAATGGTGTTGCAGGTTCTAATTGTTACTCTCCTTTACAATCATATGGTTTCCGACCCACTTATGGTGTTGGTCACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGGTGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAATATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAAGTCTCATCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAAACGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAATATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCATAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAAATTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGATTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTTACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACTCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACATTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGATAGGTGCGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAAGAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAACTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTTAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGCGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTCTCTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGTTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTTAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACTCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAAACGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCCGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json b/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json index de441105..4624e0cf 100644 --- a/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json +++ b/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json @@ -1 +1 @@ -{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-02-18","#531EA6"],["2021-02-21","#521EA7"],["2021-03-02","#4E20AC"],["2021-03-10","#4C24AF"],["2021-03-15","#4B26B1"],["2021-04-01","#472DB8"],["2021-04-07","#462FBA"],["2021-04-08","#4530BB"],["2021-04-13","#4432BD"],["2021-04-19","#4334BF"],["2021-04-20","#4335C0"],["2021-04-21","#4235C0"],["2021-04-23","#4236C1"],["2021-04-26","#4137C2"],["2021-04-30","#4039C4"],["2021-05-05","#403BC5"],["2021-05-13","#4040C6"],["2021-05-16","#4041C7"],["2021-05-21","#3F44C8"],["2021-05-25","#3F46C8"],["2021-05-26","#3F46C9"],["2021-06-04","#3F4BCA"],["2021-06-14","#3F50CC"],["2021-06-18","#3F53CD"],["2021-06-19","#3F53CD"],["2021-06-25","#3F56CE"],["2021-06-30","#3E59CF"],["2021-07-01","#3E59CF"],["2021-07-13","#3F5FD0"],["2021-07-22","#4064CF"],["2021-07-23","#4064CF"],["2021-07-26","#4066CF"],["2021-07-27","#4066CF"],["2021-07-28","#4067CF"],["2021-07-30","#4068CF"],["2021-08-02","#4169CF"],["2021-08-03","#416ACF"],["2021-08-04","#416ACF"],["2021-08-07","#416CCE"],["2021-08-09","#416DCE"],["2021-08-10","#416DCE"],["2021-08-12","#416ECE"],["2021-08-13","#416FCE"],["2021-08-16","#4270CE"],["2021-08-17","#4271CE"],["2021-08-18","#4271CE"],["2021-08-19","#4271CE"],["2021-08-22","#4273CE"],["2021-08-25","#4374CD"],["2021-08-27","#4375CD"],["2021-09-02","#4378CD"],["2021-09-03","#4379CD"],["2021-09-13","#447DCC"],["2021-09-20","#4580CA"],["2021-09-23","#4681C9"],["2021-09-24","#4682C9"],["2021-09-27","#4783C8"],["2021-09-29","#4783C8"],["2021-09-30","#4784C8"],["2021-10-04","#4885C7"],["2021-10-08","#4887C6"],["2021-10-11","#4988C5"],["2021-10-12","#4988C5"],["2021-10-18","#4A8BC3"],["2021-10-22","#4A8CC2"],["2021-10-25","#4B8DC2"],["2021-10-27","#4B8EC1"],["2021-10-28","#4B8FC1"],["2021-11-02","#4C91C0"],["2021-11-04","#4C91BF"],["2021-11-05","#4D92BF"],["2021-11-17","#4F96BC"],["2021-11-18","#4F96BB"],["2021-11-19","#4F97BB"],["2021-11-23","#5098BA"],["2021-11-24","#5098B9"],["2021-11-25","#5098B9"],["2021-11-29","#5199B7"],["2021-12-03","#529AB6"],["2021-12-07","#539BB4"],["2021-12-08","#539CB4"],["2021-12-10","#539CB3"],["2021-12-13","#549DB2"],["2021-12-14","#549DB2"],["2021-12-17","#559EB1"],["2021-12-19","#559FB0"],["2021-12-21","#569FAF"],["2021-12-22","#56A0AF"],["2021-12-26","#57A1AE"],["2021-12-28","#57A1AD"],["2022-01-01","#58A2AB"],["2022-01-05","#59A3AA"],["2022-01-07","#59A4A9"],["2022-02-16","#63AC99"],["2022-02-23","#65AD96"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-29","#6FB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-21","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Beta","#4067CF"],["Gamma","#4A8BC3"],["Delta","#5AA4A9"],["Epsilon","#6FB488"],["Eta","#8BBB69"],["Theta","#A9BD53"],["Iota","#C7B944"],["Kappa","#DDA93C"],["Lambda","#E68A35"],["Mu","#E35C2C"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","clade_who","clade_display","designation_date","designation_recency"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":true},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":false},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{},"labels":{"clade":"19A"}},"children":[{"name":"B","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":0},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{"ORF6":["D61L"],"S":["T19I"]},"labels":{"aa":"ORF6: D61L; S: T19I","spike_mutations":"T19I"}},"children":[{"name":"XAA","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAA"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A1610G","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C8247T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12445T","C12880T","C14408T","C15714T","C17410T","A18163G","A19356G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["N449D","K856R","S2083-","L2084I","S2661F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: N449D, K856R, S2083-, L2084I, S2661F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XA","node_attrs":{"div":33,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XA"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-05"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T445C","T2019C","C3037T","C4999T","C6286T","C8090T","C9430T","A10323G","C13945T","C14408T","G20410A","G21255C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23208T","C23271A","A23403G","C23604A","C23709T","T24506G","G24914C","G25855T","C27972T","G28048T","A28095T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"N":["D3L","R203K","G204R","S235F"],"ORF1a":["M585T","L2609F","K3353R"],"ORF1b":["P160S","P314L","E2315K"],"ORF3a":["D155Y"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","K68*","Y73C"],"S":["I19T","H69-","V70-","Y144-","N501Y","T549I","A570D","D614G","P681H","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, R203K, G204R, S235F; ORF1a: M585T, L2609F, K3353R; ORF1b: P160S, P314L, E2315K; ORF3a: D155Y; ORF6: L61D; ORF8: Q27*, R52I, K68*, Y73C; S: I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H","spike_mutations":"I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H"}}},{"name":"XAC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAC"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.851975917816162}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15720T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25731T","C25810T","C26028T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","A2909V","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["L140F"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, A2909V, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: L140F; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAB","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.443575382232666}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17010T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAF","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-","T3750I","V3751F"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-, T3750I, V3751F; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAG","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C2857T","C3037T","T5386G","C5585A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C12880T","C14408T","C15714T","C17410T","C17502T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","L1774I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, L1774I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAD","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAD"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.857146263122559}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","A1250G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T329A","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T329A, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAE","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAE"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","G4975A","A6390C","C9344T","A9424G","C9534T","C9803T","C9866T","C10029T","C10198T","G10447A","C10449A","C11249T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C","T29748C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","E2042A","L3027F","T3090I","L3201F","T3255I","P3395H","R3662C","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, E2042A, L3027F, T3090I, L3201F, T3255I, P3395H, R3662C, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAL","node_attrs":{"div":61,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","A2865G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","G21586T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","E867G","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L8F","L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, E867G, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K","spike_mutations":"L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K"}}},{"name":"XAK","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAK"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.3037714005953052"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4927T","T5386G","C7834T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C12880T","C14408T","C15240T","A18163G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","A22001G","T22200G","G22578A","G22599A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22942G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24863T","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","I1566V"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","H69-","V70-","G142D","K147E","V213G","G339D","R346K","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N460K","S477N","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","H1101Y"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, I1566V; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y","spike_mutations":"I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y"}}},{"name":"XAJ","node_attrs":{"div":72,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAJ"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.647030830383301}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11674T","C12880T","C14408T","T15009C","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","A23535G","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N658S","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XAH","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAH"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.713448524475098}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","G17242T","C17410T","A18163G","C18246T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33G","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","A1259S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33G, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, A1259S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAM","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAM"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T3750I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T3750I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAP","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAP"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-30"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9286975860595703}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C5407A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAR","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.44734525680542}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21796T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","R78S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAN","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAN"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.080811023712158}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7973A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","C17822T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","T27696C","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29666T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L2570M","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","P1452L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L2570M, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, P1452L, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAQ","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","C9857T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23779T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAT","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","C10277T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19317T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25810T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","A2909V","L3027F","T3090I","L3201F","T3255I","L3338F","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["L140F","T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, A2909V, L3027F, T3090I, L3201F, T3255I, L3338F, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: L140F, T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAV","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAV"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.706950664520264}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C6606T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15960T","G17278T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","S2114F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","V1271L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, S2114F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, V1271L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAU","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAU"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.173168659210205}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","T17407C","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAS","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAS"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.466667652130127}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAW","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAW"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.274687314409391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C335T","G569A","T689C","G1048T","G1125A","C1973T","C3037T","G3246A","G4181T","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9676C","C10029T","A10323G","A11201G","G11330A","A11332G","C11866T","C13806T","C13994T","C14408T","C14585T","G15451A","C16466T","C17304T","C17550T","A17973G","G18525A","C19220T","C19290T","C20402T","G20493A","C21575T","C21618G","C21636T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","T22942A","G22992A","C22995A","A23013C","T23042C","A23055G","A23063T","T23075C","C23114T","A23403G","C23525T","C23604A","C23854A","G23948T","G24145A","A24424T","T24469A","C25000T","C25584T","A25592G","C26060T","C26270T","C26537T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28562A","G28646A","C28849T","C28873T","G28881T","G28916T","G29402T","C29635T","G29742T"],"E":["T9I"],"M":["Q19E","A63T"],"N":["D63G","G97S","A125T","R203M","G215C","D377Y"],"ORF1a":["R24C","E102K","S142P","K261N","R287K","S994N","A1306S","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","T3255I","K3353R","T3646A","V3689M"],"ORF1b":["A176V","P314L","A373V","G662S","P1000L","A1918V","S2312L"],"ORF3a":["K67R","T223I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["L5F","I19R","P25L","E156-","F157-","R158G","N211-","L212I","L242-","A243-","G339D","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","N460K","S477N","T478K","E484A","S494P","Q498R","N501Y","Y505H","D614G","H655Y","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: D63G, G97S, A125T, R203M, G215C, D377Y; ORF1a: R24C, E102K, S142P, K261N, R287K, S994N, A1306S, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, T3255I, K3353R, T3646A, V3689M; ORF1b: A176V, P314L, A373V, G662S, P1000L, A1918V, S2312L; ORF3a: K67R, T223I; ORF8: D119-, F120-; ORF9b: T60A; S: L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAZ","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAZ"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1912T","C2232T","C2790T","C3037T","C3317T","T3358C","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A656V","T842I","P1018S","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A656V, T842I, P1018S, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XB","node_attrs":{"div":29,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"XB"},"totalAminoacidDeletions":{"value":5},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-18"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.699341297149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C3688T","C3884T","C6633T","A7142G","A9614G","C9693T","A9754C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14408T","G15451A","C16466T","C21057T","T21615G","C21846T","A22036C","A23403G","C23604A","C23625T","T23765G","C24442T","C24642T","G26158-","T26159-","T26160-","A26161-","C26222T","C27389T","C27769T","G28048A","A28271-","A28330G","C28854T","A28910T"],"N":["S194L","N213Y"],"ORF1a":["P1207S","A2123V","S2293G","T3117A","A3143V","R3163S","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","P1000L"],"ORF3a":["V256-","N257-","P258I","M260I","E261I","P262I","T269I","P274I","L275I"],"ORF6":["L61D"],"ORF7b":["S5L"],"ORF8":["R52K"],"ORF9b":["D16G"],"S":["L18R","I19T","T95I","R158S","D614G","P681H","A688V","S735A","T1027I"]},"labels":{"aa":"N: S194L, N213Y; ORF1a: P1207S, A2123V, S2293G, T3117A, A3143V, R3163S, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, P1000L; ORF3a: V256-, N257-, P258I, M260I, E261I, P262I, T269I, P274I, L275I; ORF6: L61D; ORF7b: S5L; ORF8: R52K; ORF9b: D16G; S: L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I","spike_mutations":"L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I"}}},{"name":"XBA","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBA"},"totalAminoacidDeletions":{"value":4},"immune_escape":{"value":"0.29808642936638835"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4181T","C6402T","C7124T","C8595T","C8986T","G9053T","C10029T","A11201G","A11332G","G13812T","C14408T","C14790T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","A22991G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","T26767C","G26959A","T27638C","A27663T","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","C28311T","A28461G","G28881A","G28882A","G28883C","G29402T","G29742T"],"M":["I82T","R146H"],"N":["P13L","D63G","R203K","G204R","D377Y"],"ORF1a":["S135R","T842I","A1306S","P2046L","P2287S","T2777I","V2930L","T3255I","T3646A"],"ORF1b":["M115I","P314L","A520V","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["P10S","T60A"],"S":["L18F","I19R","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477D","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","T1117I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, D63G, R203K, G204R, D377Y; ORF1a: S135R, T842I, A1306S, P2046L, P2287S, T2777I, V2930L, T3255I, T3646A; ORF1b: M115I, P314L, A520V, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: P10S, T60A; S: L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I","spike_mutations":"L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I"}}},{"name":"XBD","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBD"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBE","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBE"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.568920612335205}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27800T","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","T1050N","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, T1050N, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBH","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBH"},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-16"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7528T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13730T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25157A","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28881A","G28882A","G28883C","A29510C","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","T29758C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["A88V","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","D1199N"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: A88V, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N"}}},{"name":"XBG","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBG"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10116T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11665T","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","A24676G","C25000T","C25584T","C26060T","T26180C","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","T3284I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I","I263T"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, T3284I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I, I263T; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBM","node_attrs":{"div":74,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBM"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","G19891A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23202T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27549T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","D2142N","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","T547I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, D2142N, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBN","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBN"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","A2863G","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","A19459G","C19554T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C25638T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","I1998V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, I1998V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBP","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBP"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7303T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C12952T","C13965T","C14408T","C15277T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","T23773C","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","H604Y","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, H604Y, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBQ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBQ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G14829T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","M454I","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, M454I, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBR","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1093T","G1440A","A1964G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","A5844G","C8597T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21077T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22855T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25471C","C25553T","T25569C","C25584T","G26031A","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","G392D","I567V","T842I","S1221L","G1307S","P1640S","K1860R","L2778F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I","T2537I"],"ORF3a":["D27H","A54V","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, G392D, I567V, T842I, S1221L, G1307S, P1640S, K1860R, L2778F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I, T2537I; ORF3a: D27H, A54V, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBU","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBU"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","A3620V","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, A3620V, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBS","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBS"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T670G","C2790T","C2842T","C3037T","C3796T","C3809T","C3927T","G4184A","C4321T","C4586T","C5183T","C6982T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","T20748C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["G82-","H83-","V84-","M85V","S135R","T842I","L1182F","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: G82-, H83-, V84-, M85V, S135R, T842I, L1182F, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBT","node_attrs":{"div":81,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5037920175803539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C829T","C1627T","C2790T","C3037T","A3207G","G4184A","G4288A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","G23587A","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","D981G","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, D981G, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBV","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBV"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8040G","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","G15957T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123A","A23223G","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24170G","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","D2592G","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","T1050N","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","P521T","E554G","D614G","H655Y","N679K","P681H","N764K","D796Y","I870V","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, D2592G, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, T1050N, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K"}}},{"name":"XBW","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBW"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22612C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","G29260A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBY","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBY"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5812T","C9344T","A9424G","C9532T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","G19962T","A20055G","C21054T","G21305A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T28137A","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I","R2613H"],"ORF3a":["T223I"],"ORF8":["S82T"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I, R2613H; ORF3a: T223I; ORF8: S82T; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBZ","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBZ"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","T2954C","C3037T","G4184A","C4321T","C6040T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","C12880T","T14257C","C14408T","C15714T","G16935A","A17039G","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T21992-","A21993-","T21994-","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22858T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23086T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26428T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","C28770T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","V62F"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","T166I","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["Y264H","P314L","M1156I","N1191S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","Y144-","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, V62F; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, T166I, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: Y264H, P314L, M1156I, N1191S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XC","node_attrs":{"div":39,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XC"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5239T","T5514C","C6402T","C7124T","C8986T","G9053T","C10029T","A11201G","A11332G","C14408T","G15451A","C16466T","C19220T","C21618G","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22081T","T22917G","C22995A","A23403G","C23604G","G24410A","C25469T","T26767C","G27390T","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"M":["I82T"],"N":["D3L","R203K","G204R","S235F"],"ORF1a":["A1306S","V1750A","P2046L","P2287S","V2930L","T3255I","T3646A"],"ORF1b":["P314L","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","Y73C"],"S":["I19R","T95I","G142D","E156-","F157-","R158G","Q173H","L452R","T478K","D614G","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D3L, R203K, G204R, S235F; ORF1a: A1306S, V1750A, P2046L, P2287S, V2930L, T3255I, T3646A; ORF1b: P314L, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF8: Q27*, R52I, Y73C; S: I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N","spike_mutations":"I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N"}}},{"name":"XCC","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCC"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1545T","C2790T","C3037T","C3796T","C3857A","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A427V","T842I","Q1198K","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A427V, T842I, Q1198K, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCA","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCA"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2062T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C5748A","C9344T","A9424G","T9454C","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19017T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21893A","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","C22747T","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","C23595T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","T25975C","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","T1828N","L3027F","T3090I","L3201F","T3255I","P3395H","A3620V","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["S195P","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","D111N","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","T678I","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, T1828N, L3027F, T3090I, L3201F, T3255I, P3395H, A3620V, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: S195P, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCB","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCB"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","A11126G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C12880T","C14408T","C14724T","C15714T","C17410T","A18163G","G18651A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22302-","T22303-","T22304-","T22348A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27600T","C27807T","C27889T","A28271T","T28282C","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","M3621V","S3675-","G3676-","F3677-","A4016T"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","S247-","Y248N","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, M3621V, S3675-, G3676-, F3677-, A4016T; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCE","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1931A","C2790T","T2954C","C3037T","G4184A","C4321T","C9344T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15810T","T15939C","T16342C","C17410T","T17859C","A18163G","G18811A","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","Q556K","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","D1782N","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","Y200C","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, Q556K, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, D1782N, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCD","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCD"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-08"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18006C","A18163G","A19173G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22203A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","G28077T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28681T","G28881A","G28882A","G28883C","C29367T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","P365L","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","R214H","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, P365L, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF8: V62L; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCG","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8170G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCJ","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCJ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C1063T","C2790T","C3037T","G4184A","C4321T","C6312T","A6616G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22843C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27431T","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28770T","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","T166I","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","T2016I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["A13V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","G181R","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, T166I, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, T2016I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: A13V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCK","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCK"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","T2128C","C2790T","C3037T","G3242A","G4184A","C4321T","C5512T","G5720A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12880T","C12970T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18096C","A18163G","A19326G","C19955T","G19962T","A20055G","G20060T","A21137G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","C26270T","G26529A","C26577G","G26709A","G26951C","C27807T","C27889T","C28163A","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","T29726-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G993S","G1307S","G1819S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I","S2198I","K2557R"],"ORF3a":["T223I","V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G993S, G1307S, G1819S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I, S2198I, K2557R; ORF3a: T223I, V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XCL","node_attrs":{"div":101,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C7417T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15755G","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23093A","A23403G","C23525T","T23599G","C23604A","C23741T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25046T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S763C","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","V511I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","P1162S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S763C, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S"}}},{"name":"XCN","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCN"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C337T","T670G","C1142T","C1471T","C1513T","C1686T","T2372C","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7318T","C8782T","G8849A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C14408T","C14790T","T14961C","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21807A","C21910T","G21987A","A22001G","T22016C","C22033A","A22121G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","T23332C","A23403G","C23453T","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27635T","C27807T","G27915T","C28253T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","L293F","A474V","T842I","S1221L","G1307S","P1640S","V2862M","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","P82H","G142D","K147E","W152R","F157L","K187E","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","P631S","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, L293F, A474V, T842I, S1221L, G1307S, P1640S, V2862M, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: S81L; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCM","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","G331T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","C5730T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T13560C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17661C","T17859C","A18163G","A18879G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24134A","A24373G","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","A29558G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["Q22H","K47R","S135R","T842I","G1307S","T1822I","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["A72T","A110V","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","F157L","N185D","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: Q22H, K47R, S135R, T842I, G1307S, T1822I, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: A72T, A110V, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}}},{"name":"XCP","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCP"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","C3622T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","C12880T","C14408T","A14634G","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","C19185T","A19326G","C19488T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","I3758V","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, I3758V, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCQ","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","A13187G","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","A22320G","C22388T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23757T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","I4308V"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","T732I","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, I4308V; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K"}}},{"name":"XCR","node_attrs":{"div":106,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCR"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C13405T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24373C","A24424T","T24469A","C25000T","A25359G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26708G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K","K1266R"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R"}}},{"name":"XCS","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCS"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17010T","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27669G","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","A29221G","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K"}}},{"name":"XCU","node_attrs":{"div":99,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCU"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1437T","C2790T","C3037T","T3478C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","C9891T","C10029T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","A17207G","A19890G","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","T23042C","A23055G","A23063T","T23075C","C23123A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","C26606T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28376A","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","A35T","R203K","G204R","S413R"],"ORF1a":["S135R","S391F","T842I","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","A3209V","T3255I","V3718A","T3750I"],"ORF1b":["P314L","G662S","P1000L","T1050I","Y1247C"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","D215H","A222V","L242-","A243-","S256L","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","S494P","Q498R","N501Y","Y505H","P521T","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, A35T, R203K, G204R, S413R; ORF1a: S135R, S391F, T842I, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, A3209V, T3255I, V3718A, T3750I; ORF1b: P314L, G662S, P1000L, T1050I, Y1247C; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCV","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCV"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","T5422C","C7044A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27065A","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28182G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","P2260H","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, P2260H, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, S97G; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCY","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCY"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCW","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCW"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","T6394C","G6536A","G8863T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T14305C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","G18636A","T18882C","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27513T","C27684T","C27807T","G27915T","T28034C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["Y280H","P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","I210-","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: Y280H, P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCZ","node_attrs":{"div":112,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCZ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","A15436G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22609G","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26735T","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28519T","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","M657V","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-","T79I"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, M657V, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-, T79I; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XD","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.029110000000000004"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XD"},"totalAminoacidDeletions":{"value":5},"immune_escape":{"value":"0.17203353628663032"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","A1321C","C3037T","G4181T","C6402T","C7124T","C7851T","A8723G","C8986T","G9053T","C10029T","A11201G","A11332G","C14407T","C14408T","T15264C","G15451A","C16466T","C19220T","C21618G","G21641T","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25667T","G25855T","T26767C","T27638C","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G28916T","G29402T","G29540A","G29645T","G29742T"],"M":["I82T"],"N":["D63G","R203M","G215C","D377Y"],"ORF1a":["E352D","A1306S","P2046L","P2287S","A2529V","I2820V","V2930L","T3255I","T3646A"],"ORF1b":["P314F","G662S","P1000L","A1918V"],"ORF3a":["S92L","D155Y"],"ORF6":["L61D"],"ORF7a":["V82A","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["I19R","A27S","T95I","G142D","E156-","F157-","R158G","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"M: I82T; N: D63G, R203M, G215C, D377Y; ORF1a: E352D, A1306S, P2046L, P2287S, A2529V, I2820V, V2930L, T3255I, T3646A; ORF1b: P314F, G662S, P1000L, A1918V; ORF3a: S92L, D155Y; ORF6: L61D; ORF7a: V82A, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: T60A; S: I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XDB","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","G15982A","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["P314L","G662S","V839I","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: P314L, G662S, V839I, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDC","node_attrs":{"div":108,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDC"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2110T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","C15763T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21036T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDE","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","T21363C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26612G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29535T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","S302F","T842I","G1307S","P2079Q","T2283I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","P4220L"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, S302F, T842I, G1307S, P2079Q, T2283I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, P4220L; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDF","node_attrs":{"div":107,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C335T","A405G","T670G","C2790T","C3037T","T3453C","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","G27666T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","T28382C","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","S37P","R203K","G204R","S413R"],"ORF1a":["R24C","K47R","S135R","T842I","V1063A","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, S37P, R203K, G204R, S413R; ORF1a: R24C, K47R, S135R, T842I, V1063A, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: E91D; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDG","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C547T","T670G","C1758T","C2790T","C3037T","G4184A","C4321T","T4579A","T4690C","T4930C","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","T16905C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","A23598G","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","A25744G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28754T","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","L161F","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A498V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["I118V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679R","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, L161F, R203K, G204R, S413R; ORF1a: K47R, S135R, A498V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: I118V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDH","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDH"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","T2992A","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","T4744C","C5183T","T7477C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C13335T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","D909E","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S","A4357V"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, D909E, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S, A4357V; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDJ","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDJ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C8947T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","A10861G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G29081T","A29510C","C29625T","A29700G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","V270L","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","F157L","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, V270L, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDL","node_attrs":{"div":110,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2650T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","C17410T","T17859C","C17976T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","T24903C","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","C28253A","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","F120L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","I1114T"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, F120L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T"}}},{"name":"XDM","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","T24046C","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","D335G","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["T76A","P314L","G662S","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, D335G, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: T76A, P314L, G662S, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDN","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDN"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","C280T","T670G","C897A","C1762A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","C12880T","T13339C","C14408T","C14425T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","F499L","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, F499L, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K"}}},{"name":"XDS","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDS"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","G598A","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29409T","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","C29836T"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","T379I","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, T379I, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDT","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDT"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C1601T","C2790T","C3037T","G3431T","G4184A","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9344T","A9424G","C9534T","C9661T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","T25496C","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27014A","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29778A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","L446F","T842I","V1056L","G1307S","N2526S","A2710T","I2790V","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","V3892A","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["I35T","T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","H69-","V70-","V127F","G142D","Y144-","R158G","N211-","L212I","V213G","L216F","A222V","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, L446F, T842I, V1056L, G1307S, N2526S, A2710T, I2790V, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, V3892A, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: I35T, T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}}},{"name":"XDU","node_attrs":{"div":111,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDU"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.9475349114594978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","C3177T","C3587T","C3944A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","C22674T","T22679C","C22686T","A22688G","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26078T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","P971L","H1108Y","Q1227K","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I","T229I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","S371F","S373P","S375F","T376A","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, P971L, H1108Y, Q1227K, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I, T229I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDW","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDW"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","T1030C","A2127G","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14120T","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21301T","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","Y621C","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P218L","P314L","R1315C","I1566V","T2163I","P2612S"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A263V","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, Y621C, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P218L, P314L, R1315C, I1566V, T2163I, P2612S; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XDZ","node_attrs":{"div":114,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDZ"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7086T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","C23557T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","T2274I","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, T2274I, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDY","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDY"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","G19669A","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","C22858T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","G2068R","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, G2068R, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XE","node_attrs":{"div":62,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C14599T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XEA","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEA"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2268340125514634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","C13255T","T13339C","A13712G","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","D1513E","K1973R","N2526S","A2529S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["K82R","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, D1513E, K1973R, N2526S, A2529S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: K82R, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEB","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEB"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XED","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XED"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":17.361},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XED"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9430T","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","A13308G","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25350T","C25584T","C26060T","C26270T","G26529C","C26577G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","T170I","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I","K4348R"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L","P1263L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, T170I, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I, K4348R; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L"}}},{"name":"XEG","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEG"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":950.694},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEG"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","A2443G","C2790T","C2939T","C3037T","C3876T","G4184A","C4234T","C4321T","G6536A","A6646G","T6747C","C7819G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T10723C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","G19327T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","C23191T","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","P892S","A1204V","G1307S","G2091S","L2161S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","A1954S","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, P892S, A1204V, G1307S, G2091S, L2161S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, A1954S, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEE","node_attrs":{"div":125,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEE"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEE"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.013909339904785}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","G17334T","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","T2121A","T2283I","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","H146Q","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, T2121A, T2283I, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XEF","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEF"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":34.028},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEF"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7268345560655398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","G4255T","C4321T","C4683T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","A1473V","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","N211-","L212I","V213G","L216F","H245N","A264D","I332V","L335S","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, A1473V, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XG"},"totalAminoacidDeletions":{"value":9},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","T5386G","C5672T","G5924A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19855G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","P1803S","V1887I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","I2130V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, P1803S, V1887I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, I2130V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XH","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XH"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.385257720947266}},"branch_attrs":{"mutations":{"nuc":["C241T","T902C","C904A","G1244A","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28435T","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["C213R","G327S","K856R","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-","P51L"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: C213R, G327S, K856R, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-, P51L; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XF","node_attrs":{"div":57,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XF"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.623017311096191}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","T1390C","A2255G","C3037T","G4181T","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29632T"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["I664V","A1306S","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: I664V, A1306S, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XJ","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XJ"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","G11287-","T11288-","C11289-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675F","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675F, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XK","node_attrs":{"div":59,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XK"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":45},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A16064G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23403G","C23525T","T23599G","C23604A","A23767G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","R1628C","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","Q866R","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, R1628C, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, Q866R, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XL","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","C875T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G14229A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["L204F","K856R","V1887I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: L204F, K856R, V1887I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XM","node_attrs":{"div":60,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-31"},"totalAminoacidSubstitutions":{"value":46},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.202030658721924}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XN","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XN"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.321341514587402}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","G10986A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","R3574K","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, R3574K, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XP","node_attrs":{"div":59,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XP"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3616394203564539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.596989154815674}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24190C","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","C26880A","A27259C","C27807T","A28254-","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3G","Q19E","A63T","L120I"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF8":["I121-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T, L120I; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF8: I121-; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XQ","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XQ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.557485103607178}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A17615G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","K1383R","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, K1383R, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XR","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C4893T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G13295A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25524G","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","C27131T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","T1543I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","D4344N"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, T1543I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, D4344N; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XS","node_attrs":{"div":61,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XS"},"totalAminoacidDeletions":{"value":14},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.812867641448975}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5365T","C6196T","C6402T","C7124T","C8986T","G9053T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21595T","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["A1306S","P2046L","P2287S","V2930L","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: A1306S, P2046L, P2287S, V2930L, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XU","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XU"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C16887T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XT","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.945826530456543}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13994T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21786T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["A176V","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G75V","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: A176V, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XV","node_attrs":{"div":62,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XV"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.5818281173706055}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3583T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XW","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XW"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-12"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","C10507T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12756T","C12880T","C14408T","C15714T","G16020T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-","T4164I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-, T4164I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XY","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XY"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A1585G","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11049C","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","A22351G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26058T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","V3595A","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, V3595A, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XZ","node_attrs":{"div":64,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XZ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.045060634613037}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","G20398A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I","E2311K"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I, E2311K; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"internal_XBK","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBK.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","A1124G","C1973T","A2163C","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16856G","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","G25947C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27741T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R287G","E633A","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","D1130G","R1315C","I1566V","T2163I"],"ORF3a":["Q185H","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R287G, E633A, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, D1130G, R1315C, I1566V, T2163I; ORF3a: Q185H, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCH.1","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1684T","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7051T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19886G","C19955T","A20055G","C20320T","A20741G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22115G","A22190G","T22200G","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","T24073C","C24134A","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","K2140R","T2163I","H2285Y","Q2425R"],"ORF3a":["A72T","A110V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","N185D","I210V","V213G","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, K2140R, T2163I, H2285Y, Q2425R; ORF3a: A72T, A110V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}},"children":[{"name":"XCT.1","node_attrs":{"div":111,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","D335G","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["T76A","P314L","G662S","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, D335G, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: T76A, P314L, G662S, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDA.1","node_attrs":{"div":108,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18657T","C18894T","C19716T","C19955T","A20055G","C21618T","C21622T","G21624C","C21627A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25006T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28291A","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G28884C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204P","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P3H","P10S","E27-","N28-","A29-"],"S":["R21T","T22N","L24-","P25-","P26-","A27S","S50L","F59S","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204P, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P3H, P10S, E27-, N28-, A29-; S: R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":133,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":29.34},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-14"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":34.028},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4006A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17067C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","T26012G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["F207C","T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: F207C, T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCF","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T170I","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T170I, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2668T","C2790T","C3037T","G4184A","C4321T","C6896T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.1","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G3446A","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","A20379G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","A1061T","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, A1061T, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBL","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.1","node_attrs":{"div":99,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"XBL.2","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"NODE_0000016","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","C7420T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A27980G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","T29023C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDQ","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":114,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.493660926818848}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.296816825866699}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1.1","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDQ.1","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.296816825866699}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1471T","C2445T","C2790T","C3037T","G3072A","G4184A","C4321T","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10189T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C12880T","C14408T","C15714T","C17410T","C17678T","A18163G","C18252T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22020C","T22054G","T22200G","C22295A","G22332A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893G","A22910G","C22916A","T22942G","G22992A","C22995A","G23012A","A23013G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25896T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T727I","T842I","C936Y","G1307S","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","Q3922R"],"ORF1b":["P314L","R1315C","T1404M","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","M153T","N164K","V213G","H245N","G257D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444R","N450D","L452M","N460K","S477N","T478K","E484R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T727I, T842I, C936Y, G1307S, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, Q3922R; ORF1b: P314L, R1315C, T1404M, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBJ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000021","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBJ.1.1","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.2","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"XDD.3","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"NODE_0000025","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","C23277T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","T572I","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.2","node_attrs":{"div":125,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","C22928T","A23598G","C27297T"],"S":["L456F","K679R"]},"labels":{"aa":"S: L456F, K679R","spike_mutations":"L456F, K679R"}}},{"name":"XDK.3","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.635818004608154}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"internal_0964eaa1","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"XDK.4.1","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S"}}}]},{"name":"internal_C29762T","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":126,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, Q1201K","spike_mutations":"R237K, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G11596A","C18664T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.2","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.803860664367676}},"branch_attrs":{"mutations":{"nuc":["G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"NODE_0000032","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}},"children":[{"name":"XDK.1","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.1","node_attrs":{"div":129,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","T18664C","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["C241T","G625T","T670G","C1627T","C2790T","C3037T","T3339C","G4184A","C4321T","C6070T","C8692T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K120N","S135R","T842I","V1025A","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K120N, S135R, T842I, V1025A, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBF","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000034","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.2","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.10","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.3","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.5","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.6","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.9","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000035","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000036","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000037","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C12880T","C14408T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","A21623G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23423T","C23525T","T23599G","C23604A","C23679T","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","C26681T","T26767C","G26959A","C27575G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"M":["I82T","R146H"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","P2287S","T2777I","V2930L","T3255I","P3395H","S3675-","G3676-","F3677-","T4161I"],"ORF1b":["P314L","A520V","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["T61S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L18F","I19R","R21G","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","P621S","H655Y","N679K","P681H","A706V","N764K","D796Y","Q954H","N969K","T1117I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, P2287S, T2777I, V2930L, T3255I, P3395H, S3675-, G3676-, F3677-, T4161I; ORF1b: P314L, A520V, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF7a: T61S; ORF9b: P10S, E27-, N28-, A29-; S: L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I","spike_mutations":"L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000039","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000040","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.996061325073242}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.996061325073242}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000041","node_attrs":{"div":81,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15492057800293}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000217437744141}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000042","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15492057800293}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796271324157715}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.6994194984436035}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000043","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.522014617919922}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.522014617919922}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000044","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000045","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097011089324951}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000046","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.778554439544678}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000047","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.697335243225098}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752889267417711"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.495386123657227}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":95,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","S302F","T842I","G1307S","P2079Q","T2283I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","P4220L"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, S302F, T842I, G1307S, P2079Q, T2283I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, P4220L; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000049","node_attrs":{"div":119,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1.1","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":125,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.10"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1","node_attrs":{"div":119,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.11","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.11"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.6","node_attrs":{"div":126,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.4","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.5","node_attrs":{"div":124,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.14808999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5359962252743784"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.8","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000050","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2.1","node_attrs":{"div":127,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":6.25},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.26874999999999993"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.8051577060608006"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}},{"name":"XDV.1.2","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.3181399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000051","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":126,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000052","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":123,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20783000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5422010449483097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","C9891T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23670T","C23854A","G23948T","A24424T","T24469A","C25000T","C25854T","T26767C","T26819C","T27718C","C27752T","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1a":["S135R","T842I","T1543I","P1640L","S2104I","V2276I","A3209V","V3718A","T3750I"],"ORF1b":["P314L","G662S","P1000L","T1050I"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["T60A"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","P209L","L212S","D215H","A222V","L242-","A243-","S256L","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N703I","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1a: S135R, T842I, T1543I, P1640L, S2104I, V2276I, A3209V, V3718A, T3750I; ORF1b: P314L, G662S, P1000L, T1050I; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: T60A; S: P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000054","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000055","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":72,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"recombinant"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"ace2_binding":{"value":"0.6871599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"partiallyAliased":{"value":"XBC.2"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.2.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.44507236664312827"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000056","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"recombinant"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"partiallyAliased":{"value":"XBC.1"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000057","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.4"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":74,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.5"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.2.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000059","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000060","node_attrs":{"div":78,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}},{"name":"XBC.1.1.1","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.48837241784414276"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}}]}]},{"name":"NODE_0000061","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000062","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000063","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.1","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.4","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}},{"name":"KD.3","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}}]}]}]},{"name":"NODE_0000065","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.4"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.5"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000066","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000067","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"JT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7550301657183831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.6"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":85,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":85,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000069","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.7420325830319254"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}},{"name":"HW.1.2","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","clade":"22F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBB","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000071","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000072","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000073","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.3064099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.26627999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0810114368008295"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000074","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000075","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}},{"name":"XBB.8.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122063159942627}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122063159942627}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.5","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1652350425720215}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.256869792938232}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"NODE_0000081","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143524169922}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XBB.2.11.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}},{"name":"XBB.2.11","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143524169922}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000082","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65097"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.832684516906738}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"internal_d796","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":96,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":96,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.0750199999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2567103717994188"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.21","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.20","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.5","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.456076145172119}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84789"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0527558336884004"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.90647"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.901963710784912}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89932"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736186906064397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.7709600000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0079043361863298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000102","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000103","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.607783317565918}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bb69915a","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.2","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.70075"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.986824739722089"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":111,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":111,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":112,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":114,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":114,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.203644752502441}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.6","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":115,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.062752723693848}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1.10","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13558"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.062752723693848}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.3","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.49564"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0545"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.33"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-18"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.89405"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.49"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54201602935791}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.9722600000000003"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.48"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"GW.4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"XBB.1.19.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000141","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":114,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":116,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":116,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":121,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.1","node_attrs":{"div":121,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.3","node_attrs":{"div":118,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1269190311431885}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86729"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.2602599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.88502836227417}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-09"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000148","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.37.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_234859ae","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306640625}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306640625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000155","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-20"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296722412109375}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.751910209655762}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.072850704193115}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.578298091888428}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.05231"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"FW.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.09468412399292}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"XBB.1.28.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":106,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FP.4","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"XBB.1.11.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.7388600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296722412109375}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.46"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.05408"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000173","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000176","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"NODE_0000177","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.4","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.5","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FE.1.1.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"NODE_0000178","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6066099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1099290580037755"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.4","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}},{"name":"JC.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.43418"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"XBB.1.17","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000188","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10.1","node_attrs":{"div":111,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-03"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.10","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}},{"name":"GA.6","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000192","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.96117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000194","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80721"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000195","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}},{"name":"GA.7.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.90647"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000196","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":109,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":109,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.2","node_attrs":{"div":113,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}},{"name":"GA.4.1.3","node_attrs":{"div":112,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":92,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":92,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.110"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.110"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.43"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.45"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.57","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.57"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.58"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.87"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8739418983459473}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8739418983459473}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2760300636291504}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.101"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.101"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.104"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.104"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.082747936248779}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.105"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.105"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.108","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.108"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.108"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.109","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.109"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.109"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.960801124572754}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.64321231842041}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.734973192214966}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.002401351928711}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8424923419952393}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.41404999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.887559652328491}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.28225564956665}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.33","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.639432430267334}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.35","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.06293249130249}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.36","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.254280090332031}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.95377"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184874534606934}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.52","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.52"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.847869634628296}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.54"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.51","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.51"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.59","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.59"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.106780052185059}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.62"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.189829349517822}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.63"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7503247261047363}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.64"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.169807434082031}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.67"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.767808198928833}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.66"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.69","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.69"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266829013824463}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.75"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.79"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.65611457824707}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.80"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.27465295791626}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.91194"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.82"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.85"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9143218994140625}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.97"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.97"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.98","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.98"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.98"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.99"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.99"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"NODE_0000202","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.174046039581299}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762267112731934}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.809103012084961}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762267112731934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.29094"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1023732112409157"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.41123000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.282760143280029}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7288198471069336}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850557327270508}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7288198471069336}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.50"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.48403999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.71"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9061"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.03073601411565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.989252090454102}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2972187995910645}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2972187995910645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.091251373291016}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.7416800000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.73864"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.99921178817749}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.1186099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.511922359466553}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5768063068389893}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.3","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"EK.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9873000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0346353162114479"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.174569606781006}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.5.13","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5768063068389893}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.3","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.345157623291016}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.842705726623535}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.345157623291016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.3","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.4","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":114,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000241","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":108,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.20635"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2868306565498102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000244","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376531600952}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.1","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.4","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.3","node_attrs":{"div":108,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.1261900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3046787170970133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.7","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}},{"name":"JD.1.1.5","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.6","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":103,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.7","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.6","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.9","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":103,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"GK.3.1","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.4253100000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.3","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.2","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.4","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.4","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.7","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":118,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.6.1","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_34743931","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":119,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000259","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1.1","node_attrs":{"div":118,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.1446400000000003"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3541583181563797"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"KN.1","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.4131407737731934}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.106"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.106"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6764075756073}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.187679767608643}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.515899181365967}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.674118757247925}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0984206199646}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.56"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.201076984405518}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.60"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.624792575836182}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.61"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265189170837402}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.65"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8305227756500244}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.74","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9630099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.74"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0169257119491577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.72","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.72"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.78","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.78"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.76","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.76"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.102418422698975}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.8","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.449069023132324}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.81","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.81"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.6281256675720215}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.83","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.83"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.545154094696045}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.84"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.84"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.25019645690918}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.88"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.88"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.298462867736816}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.89","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.89"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.89"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.91","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.91"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.91"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.224147796630859}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.90"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.90"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.96","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.96"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.96"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.1118998527526855}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"XBB.1.5.94","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.94"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.94"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"NODE_0000263","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.83085"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.83156"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9838451476656441"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.13517951965332}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9350799999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"GB.2","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.46","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"HR.1.1","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.816847085952759}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.310755729675293}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"HT.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"XBB.1.5.49","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.816847085952759}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1.1","node_attrs":{"div":109,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}},{"name":"JB.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000274","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}},{"name":"JB.2","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.74638"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0924169334128189"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.89299"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1.1","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}},{"name":"FD.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}},{"name":"FD.2","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}},{"name":"FD.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000283","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]}]}]}]}]},{"name":"NODE_0000284","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.78204870223999}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.561348915100098}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.214216709136963}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.214216709136963}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86018"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.950188045949472"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.67693"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9788766097021935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}},{"name":"FY.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_87efaafa","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388861656188965}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8926499999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"NODE_0000297","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3936004638671875}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3936004638671875}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":106,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}}]},{"name":"internal_6436aedc","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"FY.1.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000305","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":101,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.99566912651062}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":101,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.99566912651062}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.181058645248413}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.10","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.14","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.7388600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.21","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.23","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.25","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.24","node_attrs":{"div":111,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.26","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.182722091674805}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.27","node_attrs":{"div":116,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000307","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":114,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"KJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.1","node_attrs":{"div":110,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"JM.2","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"XBB.1.16.15","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.1","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"HF.1.2","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121835708618164}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000315","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.2","node_attrs":{"div":110,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1.1","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}},{"name":"JF.1.1","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"2.14642"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}},{"name":"FU.3.1","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}}]},{"name":"NODE_0000319","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.4","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8164899999999998"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.3","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.5","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.8","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.7","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.9","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":115,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0967888832092285}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.42","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000327","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":93,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":93,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":94,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.6","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.13558"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"XBB.1.9.5","node_attrs":{"div":94,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"NODE_0000329","node_attrs":{"div":95,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.331241607666016}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":95,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":96,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927204608917236}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.064053058624268}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.2342681884765625}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.532744884490967}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.29","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.7904599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.27","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.34","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.2174906730651855}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.6","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.7","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"FL.8","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"XBB.1.9.1","node_attrs":{"div":96,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927204608917236}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000331","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0848"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9957660361777405"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}},{"name":"FL.31","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000336","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.516284465789795}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.919839382171631}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}},{"name":"FL.39","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000340","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.5920999999999998"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.2","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.98073"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1216394663867173"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10.3","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000347","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.96117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8835"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.2","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.4","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.5","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"totalAminoacidDeletions":{"value":35},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_10382b90","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_59305500","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.67327356338501}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_24b5ee08","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000358","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000359","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000361","node_attrs":{"div":111,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":114,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":113,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]}]},{"name":"NODE_0000362","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.6712799072265625}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.4","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"internal_fc124546","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"FL.2.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000366","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4584245681762695}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.93509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.3348299999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.4.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.48144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0186868047371063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000369","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.6","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}},{"name":"FL.4.5","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.3","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.8","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"FL.1.7","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"internal_18deba5f","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.89211"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9778643306477401"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5381855964660645}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5381855964660645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000374","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.06800999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000375","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}},{"name":"KC.1.1","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}}]}]},{"name":"NODE_0000376","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000377","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4.2","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HN.4","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000378","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":115,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.0007299999999998658"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005141566416802"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000379","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232717037200928}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000380","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000381","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000382","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.6197006702423096}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.12","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.13","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.11","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.14","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.7","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1186099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.6197006702423096}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}},{"name":"EG.9","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.20938"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}}]},{"name":"internal_16d15670","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}},{"name":"EG.10.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000387","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000388","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.3","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}},{"name":"EG.2.5","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.2","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.2","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}},{"name":"EG.4.5","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000391","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.3","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.5","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.6","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"EG.1.7","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"internal_e85bc240","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4.1","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}},{"name":"EG.1.4","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173667907715}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"internal_cc5f07eb","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"NODE_0000395","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000396","node_attrs":{"div":104,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":104,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.13","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.16","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.18","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.19","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.2","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.5","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000400","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.73257"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4312755323086508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-29"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000401","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000402","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{}}},{"name":"JG.2","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.1","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.4","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000404","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.2","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.4253100000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.4","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"JG.3.3","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}}]}]},{"name":"NODE_0000405","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000406","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1.10","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.025979999999999802"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.0887599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3341105633249508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.4","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.3","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.21974"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005451981781486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.7","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.8","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"internal_2378868c","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.048559999999999943"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.38161000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3552393372267753"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000408","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000410","node_attrs":{"div":115,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":115,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":118,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000411","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.19","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.17","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.13706999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1972306507819483"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.21","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.1481699999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.205901853206978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":117,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.49366"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.310148541751831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":125,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-27"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.29","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.28","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.30","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.32","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.31","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.4","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.6088199999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2183176254438959"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000418","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":119,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.48614000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3534097328298118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000422","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":117,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"NODE_0000426","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":116,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.15","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.14","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":108,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_membership":{"value":"23H"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":108,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":109,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.10","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":112,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.13","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":112,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.5","node_attrs":{"div":114,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.4","node_attrs":{"div":113,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.9","node_attrs":{"div":113,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"HK.3.7","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"internal_ca7dc568","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_membership":{"value":"23H"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":117,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":118,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000431","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.23","node_attrs":{"div":2,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.23"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.23"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.469736099243164}},"branch_attrs":{"mutations":{"nuc":["A1605-","T1606-","G1607-","C20270T","C29870A"],"ORF1a":["D448-"],"ORF1b":["A2268V"]},"labels":{"aa":"ORF1a: D448-; ORF1b: A2268V"}}},{"name":"B.3","node_attrs":{"div":2,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.0303568840026855}},"branch_attrs":{"mutations":{"nuc":["G1440A","G2891A"],"ORF1a":["G392D","A876T"]},"labels":{"aa":"ORF1a: G392D, A876T"}}},{"name":"B.55","node_attrs":{"div":1,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.55"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":0},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.333273410797119}},"branch_attrs":{"mutations":{"nuc":["T514C"]}}},{"name":"internal_f40a","node_attrs":{"div":1,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.376053333282471}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"B.4","node_attrs":{"div":4,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.114970684051514}},"branch_attrs":{"mutations":{"nuc":["G1397A","T28688C","G29742T"],"ORF1a":["V378I"]},"labels":{"aa":"ORF1a: V378I"}}},{"name":"NODE_0000433","node_attrs":{"div":3,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.597896099090576}},"branch_attrs":{"mutations":{"nuc":["C14805T","G26144T"],"ORF3a":["G251V"]},"labels":{"aa":"ORF3a: G251V"}},"children":[{"name":"B.39","node_attrs":{"div":6,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.39"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["A1515G","C9223T","T17247C"],"ORF1a":["H417R"]},"labels":{"aa":"ORF1a: H417R"}}},{"name":"B.40","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.40"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.40"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.6938891410827637}},"branch_attrs":{"mutations":{"nuc":["A2480G","C2558T"],"ORF1a":["I739V","P765S"]},"labels":{"aa":"ORF1a: I739V, P765S"}}}]},{"name":"NODE_0000434","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{"nuc":["C6312A","C13730T","C23929T","C28311T"],"N":["P13L"],"ORF1a":["T2016K"],"ORF1b":["A88V"],"ORF9b":["P10S"]},"labels":{"aa":"N: P13L; ORF1a: T2016K; ORF1b: A88V; ORF9b: P10S"}},"children":[{"name":"B.6.6","node_attrs":{"div":7,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6.6"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.6.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.402256011962891}},"branch_attrs":{"mutations":{"nuc":["C6310A","C19524T"],"ORF1a":["S2015R"]},"labels":{"aa":"ORF1a: S2015R"}}},{"name":"B.6","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000435","node_attrs":{"div":3,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.371640682220459}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S","clade":"19B"}},"children":[{"name":"A","node_attrs":{"div":3,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.371640682220459}},"branch_attrs":{"mutations":{}}},{"name":"A.1","node_attrs":{"div":6,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-3.6224653720855713}},"branch_attrs":{"mutations":{"nuc":["C17747T","A17858G","C18060T"],"ORF1b":["P1427L","Y1464C"]},"labels":{"aa":"ORF1b: P1427L, Y1464C"}}},{"name":"A.5","node_attrs":{"div":4,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.451473712921143}},"branch_attrs":{"mutations":{"nuc":["C26088T"]}}},{"name":"A.3","node_attrs":{"div":13,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.0400519371032715}},"branch_attrs":{"mutations":{"nuc":["T490A","C3177T","C6040T","G12478A","T18736C","C24034T","T26729C","G28077C","C28896G","A29700G"],"N":["A208G"],"ORF1a":["D75E","P971L","M4071I"],"ORF1b":["F1757L"],"ORF8":["V62L"]},"labels":{"aa":"N: A208G; ORF1a: D75E, P971L, M4071I; ORF1b: F1757L; ORF8: V62L"}}},{"name":"NODE_0000436","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["T9477A","C14805T","G25979T","C28657T","C28863T"],"N":["S197L"],"ORF1a":["F3071Y"],"ORF3a":["G196V"]},"labels":{"aa":"N: S197L; ORF1a: F3071Y; ORF3a: G196V"}},"children":[{"name":"A.2","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000437","node_attrs":{"div":27,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{"nuc":["C275T","C1567T","C4543T","A5234G","A5488G","C10029T","C11005A","C12815T","C16466T","T16857C","T18417C","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T22917G","A23403G","G24697A","C25613T","C26681T","A28272T","G28975T","C29421T"],"N":["M234I","P383L"],"ORF1a":["L4F","K1657E","T3255I","H3580Q"],"ORF1b":["P1000L"],"ORF3a":["S74F"],"S":["L141-","G142-","V143-","L452R","D614G"]},"labels":{"aa":"N: M234I, P383L; ORF1a: L4F, K1657E, T3255I, H3580Q; ORF1b: P1000L; ORF3a: S74F; S: L141-, G142-, V143-, L452R, D614G","spike_mutations":"L141-, G142-, V143-, L452R, D614G"}},"children":[{"name":"A.2.5","node_attrs":{"div":27,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{}}},{"name":"A.2.5.1","node_attrs":{"div":29,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.277773380279541}},"branch_attrs":{"mutations":{"nuc":["C1722T","C29366T"],"N":["P365S"],"ORF1a":["A486V"]},"labels":{"aa":"N: P365S; ORF1a: A486V"}}},{"name":"A.2.5.2","node_attrs":{"div":30,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.2"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.212984561920166}},"branch_attrs":{"mutations":{"nuc":["T15326C","A22525G","G27706T"],"ORF1b":["M620T"],"ORF7a":["A105S"]},"labels":{"aa":"ORF1b: M620T; ORF7a: A105S"}}},{"name":"A.2.5.3","node_attrs":{"div":30,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-04"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["G2272A","G22992A","C29870A"],"S":["S477N"]},"labels":{"aa":"S: S477N","spike_mutations":"S477N"}}}]}]},{"name":"NODE_0000438","node_attrs":{"div":5,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.395697593688965}},"branch_attrs":{"mutations":{"nuc":["G28878A","G29742A"],"N":["S202N"]},"labels":{"aa":"N: S202N"}},"children":[{"name":"A.18","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.221602916717529}},"branch_attrs":{"mutations":{"nuc":["A3234T","C15126T","A23403G","C27812T"],"ORF1a":["Q990L"],"S":["D614G"]},"labels":{"aa":"ORF1a: Q990L; S: D614G","spike_mutations":"D614G"}}},{"name":"A.21","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.21"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.21"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C10138T","G11417T","G23402A","G25687T"],"ORF1a":["V3718F"],"ORF3a":["A99S"],"S":["D614N"]},"labels":{"aa":"ORF1a: V3718F; ORF3a: A99S; S: D614N","spike_mutations":"D614N"}}},{"name":"NODE_0000439","node_attrs":{"div":6,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.657860279083252}},"branch_attrs":{"mutations":{"nuc":["G22468T"]}},"children":[{"name":"A.28","node_attrs":{"div":20,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.28"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-18"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A481G","G521T","C2197T","G10850A","C12469T","C16391T","G17014T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A23064C","C23525T","C25904T","C27294T","A27489G","A28272T","C28377T"],"N":["A35V"],"ORF1a":["V86F","A3529T"],"ORF1b":["A975V","D1183Y"],"ORF3a":["S171L"],"ORF9b":["R32C"],"S":["H69-","V70-","N501T","H655Y"]},"labels":{"aa":"N: A35V; ORF1a: V86F, A3529T; ORF1b: A975V, D1183Y; ORF3a: S171L; ORF9b: R32C; S: H69-, V70-, N501T, H655Y","spike_mutations":"H69-, V70-, N501T, H655Y"}}},{"name":"NODE_0000440","node_attrs":{"div":7,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A361G"]}},"children":[{"name":"A.19","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.19"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.19"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12820G","A23403G"],"S":["D614G"]},"labels":{"aa":"S: D614G","spike_mutations":"D614G"}}},{"name":"A.27","node_attrs":{"div":24,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.27"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-18"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C1122T","C2509T","A9204G","A11217G","C16466T","A18366G","A20262G","C21614T","T22917G","A23063T","C23520T","C23525T","G23948T","G25218T","T25541C","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","C27247T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28273T"],"ORF1a":["P286L","D2980G","N3651S"],"ORF1b":["P1000L"],"ORF3a":["V50A","N257-","P258-"],"ORF8":["D119-","F120-"],"S":["L18F","L452R","N501Y","A653V","H655Y","D796Y","G1219V"]},"labels":{"aa":"ORF1a: P286L, D2980G, N3651S; ORF1b: P1000L; ORF3a: V50A, N257-, P258-; ORF8: D119-, F120-; S: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V","spike_mutations":"L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V"}}}]}]},{"name":"NODE_0000441","node_attrs":{"div":7,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G11230T","G28167A"],"ORF1a":["M3655I"],"ORF8":["E92K"]},"labels":{"aa":"ORF1a: M3655I; ORF8: E92K"}},"children":[{"name":"A.25","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.25"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.25"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5544T"],"ORF1a":["T1760I"]},"labels":{"aa":"ORF1a: T1760I"}}},{"name":"A.29","node_attrs":{"div":24,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"S:142-143"},"partiallyAliased":{"value":"A.29"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-21"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G521T","C2110T","C8605T","C9891T","C12970T","G17964T","A19426G","A21069G","G21255T","T21982-","T21983-","T21984-","G21985-","T21992-","A21993-","A22194-","T22195-","T22196-","T22907C","A23063T","T23255C","C23525T","T26767G","G27604T","A28271-","G28337T","C29739T"],"M":["I82S"],"N":["D22Y"],"ORF1a":["V86F","A3209V"],"ORF1b":["M1499I","I1987V"],"ORF7a":["V71L"],"ORF9b":["Q18H"],"S":["F140-","L141-","Y144-","N211-","L212I","Y449H","N501Y","F565L","H655Y"]},"labels":{"aa":"M: I82S; N: D22Y; ORF1a: V86F, A3209V; ORF1b: M1499I, I1987V; ORF7a: V71L; ORF9b: Q18H; S: F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y","spike_mutations":"F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y"}}},{"name":"NODE_0000442","node_attrs":{"div":18,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C4573T","C10747T","G11266T","C16575T","C17745T","C22000T","C22033A","G22661T","G23401T","T24097C","G28378C"],"ORF1a":["L3667F"],"ORF9b":["R32P"],"S":["F157L","V367F","Q613H"]},"labels":{"aa":"ORF1a: L3667F; ORF9b: R32P; S: F157L, V367F, Q613H","spike_mutations":"F157L, V367F, Q613H"}},"children":[{"name":"A.23","node_attrs":{"div":18,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.23"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"A.23.1","node_attrs":{"div":20,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.23.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["G11521T","C23604G"],"ORF1a":["M3752I"],"S":["P681R"]},"labels":{"aa":"ORF1a: M3752I; S: P681R","spike_mutations":"P681R"}}}]}]}]}]},{"name":"NODE_0000443","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C14408T","A23403G"],"ORF1b":["P314L"],"S":["D614G"]},"labels":{"aa":"ORF1b: P314L; S: D614G","clade":"20A","spike_mutations":"D614G"}},"children":[{"name":"B.1","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{}}},{"name":"B.1.126","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.126"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.126"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1042866706848145}},"branch_attrs":{"mutations":{"nuc":["T3011C","G22205T","T27869C","T28853G"],"N":["S194A"],"S":["D215Y"]},"labels":{"aa":"N: S194A; S: D215Y","spike_mutations":"D215Y"}}},{"name":"B.1.143","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.143"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.143"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.873954772949219}},"branch_attrs":{"mutations":{"nuc":["C4084T"]}}},{"name":"B.1.128","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.128"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.128"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9753756523132324}},"branch_attrs":{"mutations":{"nuc":["C8293T","T18488C","T24739C","A26530G"],"M":["D3G"],"ORF1b":["I1674T"]},"labels":{"aa":"M: D3G; ORF1b: I1674T"}}},{"name":"B.1.179","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.179"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.179"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.5756611824035645}},"branch_attrs":{"mutations":{"nuc":["C7834T"]}}},{"name":"B.1.195","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.195"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.195"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.644052028656006}},"branch_attrs":{"mutations":{"nuc":["A1T","A6466G"]}}},{"name":"B.1.206","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.206"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.206"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.032867431640625}},"branch_attrs":{"mutations":{"nuc":["G2282A","T9742C","C17639T"],"ORF1a":["E673K"],"ORF1b":["S1391L"]},"labels":{"aa":"ORF1a: E673K; ORF1b: S1391L"}}},{"name":"B.1.22","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.22"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.22"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.218015670776367}},"branch_attrs":{"mutations":{"nuc":["C1594T","C11109T","G25563T"],"ORF1a":["A3615V"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: A3615V; ORF3a: Q57H"}}},{"name":"B.1.222","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.222"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.222"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.234422206878662}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.247","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.247"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.247"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{}}},{"name":"B.1.260","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.260"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.260"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.373773574829102}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}}},{"name":"B.1.298","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.298"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.298"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.417770862579346}},"branch_attrs":{"mutations":{"nuc":["C1059T","G5012T","C19488T","G25563T","T28843G"],"N":["S190R"],"ORF1a":["T265I","V1583F"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S190R; ORF1a: T265I, V1583F; ORF3a: Q57H"}}},{"name":"B.1.311","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.311"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.311"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6185555458068848}},"branch_attrs":{"mutations":{"nuc":["C1059T","A5011C","C12525T","G25563T","C27920T","C28893T"],"N":["P207L"],"ORF1a":["T265I","Q1582H","T4087I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: P207L; ORF1a: T265I, Q1582H, T4087I; ORF3a: Q57H"}}},{"name":"B.1.319","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.319"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.319"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.19646692276001}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10851T","G25563T"],"ORF1a":["T265I","A3529V"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, A3529V; ORF3a: Q57H"}}},{"name":"B.1.324","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.324"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.324"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.300193786621094}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7528T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.320","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.320"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.320"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.052657604217529}},"branch_attrs":{"mutations":{"nuc":["A1G","C379A","C1059T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.349","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.349"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.349"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.087948799133301}},"branch_attrs":{"mutations":{"nuc":["C1059T","C18555T","G25563T","C28892T"],"N":["P207S"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: P207S; ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.340","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.340"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.340"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.638462543487549}},"branch_attrs":{"mutations":{"nuc":["C1059T","A4197G","G25563T","A28715T"],"N":["T148S"],"ORF1a":["T265I","E1311G"],"ORF3a":["Q57H"]},"labels":{"aa":"N: T148S; ORF1a: T265I, E1311G; ORF3a: Q57H"}}},{"name":"B.1.350","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.350"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.350"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515401363372803}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25217T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"S":["G1219C"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; S: G1219C","spike_mutations":"G1219C"}}},{"name":"B.1.356","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.356"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.356"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.372903347015381}},"branch_attrs":{"mutations":{"nuc":["C1059T","T13006C","G25563T","C25688T"],"ORF1a":["T265I"],"ORF3a":["Q57H","A99V"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H, A99V"}}},{"name":"B.1.371","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.371"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.371"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0627546310424805}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","G29553A"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.377","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.377"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.377"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.690332889556885}},"branch_attrs":{"mutations":{"nuc":["G28300T","G28883A","A28998G"],"N":["Q9H","G204R","Q242R"],"ORF9b":["S6I"]},"labels":{"aa":"N: Q9H, G204R, Q242R; ORF9b: S6I"}}},{"name":"B.1.379","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.379"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.379"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.871178150177002}},"branch_attrs":{"mutations":{"nuc":["A11782G"]}}},{"name":"B.1.380","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.380"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.380"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0439043045043945}},"branch_attrs":{"mutations":{"nuc":["C7420T","C12439T","T26017G"],"ORF3a":["S209A"]},"labels":{"aa":"ORF3a: S209A"}}},{"name":"B.1.391","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.391"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.391"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.035602569580078}},"branch_attrs":{"mutations":{"nuc":["C16289T","G25429T"],"ORF1b":["A941V"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1b: A941V; ORF3a: V13L"}}},{"name":"B.1.393","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.393"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.393"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.20594596862793}},"branch_attrs":{"mutations":{"nuc":["A5040G","G29477T","C29774T"],"N":["D402Y"],"ORF1a":["Q1592R"]},"labels":{"aa":"N: D402Y; ORF1a: Q1592R"}}},{"name":"B.1.395","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.395"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.395"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.245898246765137}},"branch_attrs":{"mutations":{"nuc":["C6990T"],"ORF1a":["S2242F"]},"labels":{"aa":"ORF1a: S2242F"}}},{"name":"B.1.411","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.411"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.411"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.553281307220459}},"branch_attrs":{"mutations":{"nuc":["C1519T","A14774G","G15438T","T16062C","G17334T","C25037T","C27945T"],"ORF1b":["D436G","M657I"],"ORF8":["Q18*"],"S":["H1159Y"]},"labels":{"aa":"ORF1b: D436G, M657I; ORF8: Q18*; S: H1159Y","spike_mutations":"H1159Y"}}},{"name":"B.1.428","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.428"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.428"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.162219524383545}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1302T","G25563T"],"ORF1a":["T265I","T346I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, T346I; ORF3a: Q57H"}}},{"name":"B.1.453","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.453"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.453"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.023926258087158}},"branch_attrs":{"mutations":{"nuc":["C1059T","C2668T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.517","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.517"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.517"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8103365898132324}},"branch_attrs":{"mutations":{"nuc":["C1059T","G3231T","A12850G","C21364T","A23064C","G25563T","C28890T"],"N":["S206F"],"ORF1a":["T265I","G989V"],"ORF1b":["P2633S"],"ORF3a":["Q57H"],"S":["N501T"]},"labels":{"aa":"N: S206F; ORF1a: T265I, G989V; ORF1b: P2633S; ORF3a: Q57H; S: N501T","spike_mutations":"N501T"}}},{"name":"B.1.527","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.527"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.527"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.679739952087402}},"branch_attrs":{"mutations":{"nuc":["A1G","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}}},{"name":"B.1.537","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.537"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.537"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.6834211349487305}},"branch_attrs":{"mutations":{"nuc":["G4354A","C6573T","C25528T"],"ORF1a":["S2103F"],"ORF3a":["L46F"]},"labels":{"aa":"ORF1a: S2103F; ORF3a: L46F"}}},{"name":"B.1.538","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.538"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.538"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.957637310028076}},"branch_attrs":{"mutations":{"nuc":["C313T","C5700A","C29870A"],"ORF1a":["A1812D"]},"labels":{"aa":"ORF1a: A1812D"}}},{"name":"B.1.540","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.540"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.540"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.101133823394775}},"branch_attrs":{"mutations":{"nuc":["G28221T"],"ORF8":["E110*"]},"labels":{"aa":"ORF8: E110*"}}},{"name":"B.1.544","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.544"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.544"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.623403549194336}},"branch_attrs":{"mutations":{"nuc":["G13348T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"B.1.549","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.549"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.549"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.000475883483887}},"branch_attrs":{"mutations":{"nuc":["C1514T","G5542T","C10029T","A11451G","G17122T","G17320T","C18463T","G23611A"],"ORF1a":["H417Y","Q1759H","T3255I","Q3729R"],"ORF1b":["A1219S","A1285S","P1666S"]},"labels":{"aa":"ORF1a: H417Y, Q1759H, T3255I, Q3729R; ORF1b: A1219S, A1285S, P1666S"}}},{"name":"B.1.560","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.560"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.560"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.553897380828857}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}}},{"name":"B.1.566","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.566"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.566"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.201295375823975}},"branch_attrs":{"mutations":{"nuc":["C1059T","C13860T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.570","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.570"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.570"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.377383232116699}},"branch_attrs":{"mutations":{"nuc":["C1059T","T7767C","G11087A","C13452T","C21161T","C23604T","G25455T","G25563T","T29867A","G29868A","C29870A"],"ORF1a":["T265I","I2501T","E3608K","A4396V"],"ORF1b":["A2565V"],"ORF3a":["K21N","Q57H"],"S":["P681L"]},"labels":{"aa":"ORF1a: T265I, I2501T, E3608K, A4396V; ORF1b: A2565V; ORF3a: K21N, Q57H; S: P681L","spike_mutations":"P681L"}}},{"name":"B.1.576","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.576"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.576"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.5748648643493652}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.606","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.606"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.606"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.854406833648682}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10015T","G14829T","C23191T","G25563T","G26769T"],"M":["A83S"],"ORF1a":["T265I"],"ORF1b":["M454I"],"ORF3a":["Q57H"]},"labels":{"aa":"M: A83S; ORF1a: T265I; ORF1b: M454I; ORF3a: Q57H"}}},{"name":"B.1.605","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.605"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.605"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.770111560821533}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10747T","C13694T","T14103C","C24909A","G25563T"],"ORF1a":["T265I"],"ORF1b":["T76I"],"ORF3a":["Q57H"],"S":["T1116N"]},"labels":{"aa":"ORF1a: T265I; ORF1b: T76I; ORF3a: Q57H; S: T1116N","spike_mutations":"T1116N"}}},{"name":"B.1.618","node_attrs":{"div":25,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.618"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.618"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-13"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G105T","C853T","C1684T","A3830G","C4809T","T5263C","G14245A","A17066G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","G23012A","T25084C","C25844T","C26885T","G26909T","C27493T","G27852T","A27979T","G28325A","G28628T","G28922T","G28975T","G29372C"],"N":["G18S","A119S","A217S","M234I","E367Q"],"ORF1a":["S1189G","S1515F"],"ORF1b":["D260N","Y1200C"],"ORF3a":["T151I"],"ORF7a":["P34S"],"ORF7b":["E33*"],"ORF8":["Q29L"],"S":["Y145-","H146-","E484K"]},"labels":{"aa":"N: G18S, A119S, A217S, M234I, E367Q; ORF1a: S1189G, S1515F; ORF1b: D260N, Y1200C; ORF3a: T151I; ORF7a: P34S; ORF7b: E33*; ORF8: Q29L; S: Y145-, H146-, E484K","spike_mutations":"Y145-, H146-, E484K"}}},{"name":"B.1.639","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.639"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.639"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.9996724128723145}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22020C","C22995A","G23012A","C24138A","G24368T","A26161-","T27919C","A28271G","A28742G"],"N":["I157V"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF3a":["N257-"],"ORF8":["I9T"],"S":["H69-","V70-","M153T","T478K","E484K","T859N","D936Y"]},"labels":{"aa":"N: I157V; ORF1a: S3675-, G3676-, F3677-; ORF3a: N257-; ORF8: I9T; S: H69-, V70-, M153T, T478K, E484K, T859N, D936Y","spike_mutations":"H69-, V70-, M153T, T478K, E484K, T859N, D936Y"}}},{"name":"B.1.78","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.78"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.78"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.457021713256836}},"branch_attrs":{"mutations":{"nuc":["G29422T"]}}},{"name":"B.1.8","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.388116359710693}},"branch_attrs":{"mutations":{"nuc":["A24862G"]}}},{"name":"B.1.91","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.91"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.91"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.194854259490967}},"branch_attrs":{"mutations":{"nuc":["G24077T"],"S":["D839Y"]},"labels":{"aa":"S: D839Y","spike_mutations":"D839Y"}}},{"name":"NODE_0000444","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515961647033691}},"branch_attrs":{"mutations":{"nuc":["C8389T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.110","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.110"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515961647033691}},"branch_attrs":{"mutations":{}}},{"name":"B.1.110.3","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.110.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.013051509857178}},"branch_attrs":{"mutations":{"nuc":["C601T","G27915A"],"ORF8":["G8R"]},"labels":{"aa":"ORF8: G8R"}}}]},{"name":"NODE_0000445","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.175020217895508}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10582T","G25563T","C27804T","C28830A"],"N":["S186Y"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S186Y; ORF1a: T265I; ORF3a: Q57H"}},"children":[{"name":"B.1.367","node_attrs":{"div":27,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.367"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.367"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C3099T","G4960T","C4965T","C6070T","C7303T","C7564T","C9246T","C10279T","C10301A","C10525T","G10688T","G11851T","C14230A","G21800T","G27632T","G29402T","G29779T"],"N":["D377Y"],"ORF1a":["T945I","T1567I","A2994V","Q3346K","V3475F","M3862I"],"ORF1b":["P255T"],"ORF7a":["R80I"],"S":["D80Y"]},"labels":{"aa":"N: D377Y; ORF1a: T945I, T1567I, A2994V, Q3346K, V3475F, M3862I; ORF1b: P255T; ORF7a: R80I; S: D80Y","spike_mutations":"D80Y"}}},{"name":"B.1.597","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.597"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.597"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.175020217895508}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000446","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{"nuc":["C1059T","C16260T","G25563T","C28821A"],"N":["S183Y"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S183Y; ORF1a: T265I; ORF3a: Q57H"}},"children":[{"name":"B.1.369","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.369"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.369"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{"nuc":["A1C"]}}},{"name":"B.1.564","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.564"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.564"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000447","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.648159980773926}},"branch_attrs":{"mutations":{"nuc":["C2416T","C14322T","C23604A","G23948T","G25563T","T26038C"],"ORF3a":["Q57H","S216P"],"S":["P681H","D796Y"]},"labels":{"aa":"ORF3a: Q57H, S216P; S: P681H, D796Y","spike_mutations":"P681H, D796Y"}},"children":[{"name":"B.1.474","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.474"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.474"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.585629463195801}},"branch_attrs":{"mutations":{"nuc":["C539T","C5884T","C7834T","G8618A","C15579T","G16912T","C25207T","C26600T","C27970A","C28887T"],"N":["T205I"],"ORF1a":["L92F","A2785T"],"ORF1b":["V1149L"],"ORF8":["T26N"]},"labels":{"aa":"N: T205I; ORF1a: L92F, A2785T; ORF1b: V1149L; ORF8: T26N"}}},{"name":"B.1.629","node_attrs":{"div":29,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.629"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.629"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-01"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C815T","C1191T","C3040T","A4229C","T5095C","C5178T","G11128A","C12459T","G21987A","A22107G","T22917G","C22995A","G25266T","C25433T","T26498C","T26767G","A28482G","C28833T","C28926T"],"M":["I82S"],"N":["Q70R","S187L","A218V"],"ORF1a":["R184C","P309L","T1322P","T1638I","M3621I","T4065I"],"ORF3a":["T14I"],"ORF9b":["K67E"],"S":["G142D","K182R","L452R","T478K","C1235F"]},"labels":{"aa":"M: I82S; N: Q70R, S187L, A218V; ORF1a: R184C, P309L, T1322P, T1638I, M3621I, T4065I; ORF3a: T14I; ORF9b: K67E; S: G142D, K182R, L452R, T478K, C1235F","spike_mutations":"G142D, K182R, L452R, T478K, C1235F"}}}]},{"name":"NODE_0000448","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.43609094619751}},"branch_attrs":{"mutations":{"nuc":["C1059T","T9867C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C25517T","G25563T","C27925T","A28271-"],"ORF1a":["T265I","L3201P","S3675-","G3676-","F3677-"],"ORF3a":["P42L","Q57H"],"ORF8":["T11I"]},"labels":{"aa":"ORF1a: T265I, L3201P, S3675-, G3676-, F3677-; ORF3a: P42L, Q57H; ORF8: T11I"}},"children":[{"name":"B.1.526","node_attrs":{"div":14,"clade_display":{"value":"21F (Iota)"},"Nextclade_pango":{"value":"B.1.526"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21F"},"clade_who":{"value":"Iota"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.526"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"21F"},"placement_prior":{"value":-2.5307040214538574}},"branch_attrs":{"mutations":{"nuc":["A16500C","A20262G","C21575T","C21846T","A22320G"],"ORF1b":["Q1011H"],"S":["L5F","T95I","D253G"]},"labels":{"aa":"ORF1b: Q1011H; S: L5F, T95I, D253G","clade":"Iota","spike_mutations":"L5F, T95I, D253G"}}},{"name":"B.1.637","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.637"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.637"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0134620666503906}},"branch_attrs":{"mutations":{"nuc":["A9749G","C9891T","G11804A","A21801G","T21992-","A21993-","T21994-","T22032C","T22917G","C24138A","G24410C","G28044T","C28887T","G28975A"],"N":["T205I","M234I"],"ORF1a":["K3162E","A3209V","V3847I"],"ORF8":["A51S"],"S":["D80G","Y144-","F157S","L452R","T859N","D950H"]},"labels":{"aa":"N: T205I, M234I; ORF1a: K3162E, A3209V, V3847I; ORF8: A51S; S: D80G, Y144-, F157S, L452R, T859N, D950H","spike_mutations":"D80G, Y144-, F157S, L452R, T859N, D950H"}}}]},{"name":"NODE_0000449","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.79054069519043}},"branch_attrs":{"mutations":{"nuc":["G3871T"],"ORF1a":["K1202N"]},"labels":{"aa":"ORF1a: K1202N"}},"children":[{"name":"B.1.378","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.378"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.378"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.79054069519043}},"branch_attrs":{"mutations":{"nuc":["A6-","G7-","G8-","T9-","T13-","A14-","C15-","C16-","T17-","T18-","C19-","C20-","C21-","A22-","G23-","G24-"]}}},{"name":"NODE_0000450","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.390692710876465}},"branch_attrs":{"mutations":{"nuc":["A696C","T3931C","C28977T"],"N":["S235F"],"ORF1a":["D144A"]},"labels":{"aa":"N: S235F; ORF1a: D144A"}},"children":[{"name":"B.1.139","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.139"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.139"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.390692710876465}},"branch_attrs":{"mutations":{}}},{"name":"B.1.565","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.565"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.565"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.867055892944336}},"branch_attrs":{"mutations":{"nuc":["C6285T","C19524T","C20429T"],"ORF1a":["T2007I"],"ORF1b":["P2321L"]},"labels":{"aa":"ORF1a: T2007I; ORF1b: P2321L"}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.336426258087158}},"branch_attrs":{"mutations":{"nuc":["C1059T","C6730T","T23042C","C23604A","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"S":["S494P","P681H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; S: S494P, P681H","spike_mutations":"S494P, P681H"}},"children":[{"name":"B.1.623","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.623"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.623"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-13"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["T8704C","C9120T","C9870T","C11005A","C12854T","C13458T","G14559A","A23063T","G24893A","A27926-","A27927-","C27928-","T27929-","G27930-","T27931-","A27932-","G27933-","C27934-","T27935-","G27936-","C27937-","A27938-","T27939-","T27940-","T27941-","C27942-","A27943-","C27944-","C27945-","A27946-","A27947-","G27948-","A27949-","A27950-","T27951-","G27952-","T27953-","A27954-","G27955-","A28272T","G28975A"],"N":["M234I"],"ORF1a":["T2952I","T3202M","H3580Q","P4197S","S4398L"],"ORF8":["T12-","V13-","A14-","A15-","F16-","H17-","Q18-","E19-","C20-","S21-"],"S":["N501Y","E1111K"]},"labels":{"aa":"N: M234I; ORF1a: T2952I, T3202M, H3580Q, P4197S, S4398L; ORF8: T12-, V13-, A14-, A15-, F16-, H17-, Q18-, E19-, C20-, S21-; S: N501Y, E1111K","spike_mutations":"N501Y, E1111K"}}},{"name":"NODE_0000452","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8313348293304443}},"branch_attrs":{"mutations":{"nuc":["A1C","A1180G","C6936T","C10029T","C11514T","C16375T","T20748C","C23709T","T26767C","A28271-","C28887T","G29711-","C29719T"],"M":["I82T"],"N":["T205I"],"ORF1a":["S2224F","T3255I","T3750I"],"ORF1b":["P970S"],"S":["T716I"]},"labels":{"aa":"M: I82T; N: T205I; ORF1a: S2224F, T3255I, T3750I; ORF1b: P970S; S: T716I","spike_mutations":"T716I"}},"children":[{"name":"B.1.575","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.575"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8313348293304443}},"branch_attrs":{"mutations":{}}},{"name":"B.1.575.1","node_attrs":{"div":22,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.575.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.644876003265381}},"branch_attrs":{"mutations":{"nuc":["G29513T","C29614T"],"N":["A414S"]},"labels":{"aa":"N: A414S"}}}]}]},{"name":"NODE_0000453","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.800264835357666}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","C23625T","A26161-"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"B.1.634","node_attrs":{"div":27,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.634"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.634"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G613A","C841T","A7142G","T8634C","A9614G","C9693T","A9754C","C11289-","G11291-","G11292-","G15451A","C16466T","C20823T","T21615G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A22036C","G23012A","C23854A","C26681T","T27645C","C27735T","A28271T","C28531T","C28606T","A28910T"],"N":["N213Y"],"ORF1a":["S2293G","I2790T","T3117A","A3143V","R3163S","S3675-","G3676-","F3677-"],"ORF1b":["G662S","P1000L"],"ORF3a":["N257-"],"ORF9b":["T83I"],"S":["L18R","H69-","V70-","T95I","R158S","E484K","N764K"]},"labels":{"aa":"N: N213Y; ORF1a: S2293G, I2790T, T3117A, A3143V, R3163S, S3675-, G3676-, F3677-; ORF1b: G662S, P1000L; ORF3a: N257-; ORF9b: T83I; S: L18R, H69-, V70-, T95I, R158S, E484K, N764K","spike_mutations":"L18R, H69-, V70-, T95I, R158S, E484K, N764K"}}},{"name":"NODE_0000454","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.438127517700195}},"branch_attrs":{"mutations":{"nuc":["C24642T"],"S":["T1027I"]},"labels":{"aa":"S: T1027I","spike_mutations":"T1027I"}},"children":[{"name":"B.1.636","node_attrs":{"div":18,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.636"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.636"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","C5907T","C5986T","A9085G","C11289-","G11291-","G11292-","C21614T","A22005C","G23867A","C25931T","-26161A","C27925T","A28295T","A28742G","G29734C"],"N":["N8Y","I157V"],"ORF1a":["T1881I","S3675-","G3676-","F3677-"],"ORF3a":["S180F"],"ORF8":["T11I"],"ORF9b":["K4N"],"S":["L18F","N148T","G769R"]},"labels":{"aa":"N: N8Y, I157V; ORF1a: T1881I, S3675-, G3676-, F3677-; ORF3a: S180F; ORF8: T11I; ORF9b: K4N; S: L18F, N148T, G769R","spike_mutations":"L18F, N148T, G769R"}}},{"name":"NODE_0000455","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A994G","G9756A","C9924T","A10982G","G11283-","T11284-","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C23604A","T23765G","C24442T","G26158-","T26159-","T26160-","C26222T"],"ORF1a":["R3164H","A3220V","K3573E","S3673-"],"ORF3a":["V256-","N257-"],"S":["P681H","S735A"]},"labels":{"aa":"ORF1a: R3164H, A3220V, K3573E, S3673-; ORF3a: V256-, N257-; S: P681H, S735A","spike_mutations":"P681H, S735A"}},"children":[{"name":"B.1.627","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.627"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.627"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-01"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C1912T","C7869T","C9611T","T11285-","T20124A","T21752A","T22020C","C28923T","T29574-","T29575-","T29576-","T29577-","C29578-","G29579-","C29580-"],"N":["A217V"],"ORF1a":["S2535L","L3116F","L3674M"],"S":["W64R","M153T"]},"labels":{"aa":"N: A217V; ORF1a: S2535L, L3116F, L3674M; S: W64R, M153T","spike_mutations":"W64R, M153T"}}},{"name":"B.1.631","node_attrs":{"div":28,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.631"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.631"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-26"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C829T","C4534T","C6120T","G7787A","A11282-","T21615G","C21846T","A22036C","C22916A","C25465T","C27769T","A28271-","A28330G","C28830T","G28907T","C28957T"],"N":["S186F","G212C"],"ORF1a":["S1952L","A2508T"],"ORF3a":["P25S"],"ORF7b":["S5L"],"ORF9b":["D16G"],"S":["L18R","T95I","R158S","L452M"]},"labels":{"aa":"N: S186F, G212C; ORF1a: S1952L, A2508T; ORF3a: P25S; ORF7b: S5L; ORF9b: D16G; S: L18R, T95I, R158S, L452M","spike_mutations":"L18R, T95I, R158S, L452M"}}}]}]}]},{"name":"NODE_0000456","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8648552894592285}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.524","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.524"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.524"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.313449859619141}},"branch_attrs":{"mutations":{"nuc":["C6312T","C8637T","A10124G","C17518T","C21516T","C21622A","C23664T","A28133T"],"ORF1a":["T2016I","T2791I","T3287A"],"ORF1b":["L1351F"],"S":["A701V"]},"labels":{"aa":"ORF1a: T2016I, T2791I, T3287A; ORF1b: L1351F; S: A701V","spike_mutations":"A701V"}}},{"name":"NODE_0000457","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.2996320724487305}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.362","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.362"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.362"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.244770526885986}},"branch_attrs":{"mutations":{"nuc":["C683T","C1059T","C6402T","T10249C","G11083T","G17427T"],"ORF1a":["T265I","P2046L","L3606F"]},"labels":{"aa":"ORF1a: T265I, P2046L, L3606F"}}},{"name":"NODE_0000458","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.4366543292999268}},"branch_attrs":{"mutations":{"nuc":["C2416T"]}},"children":[{"name":"B.1.279","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.279"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.279"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.854538679122925}},"branch_attrs":{"mutations":{"nuc":["C1913T","G2528A","C12525T","C16806T","G20014T","A25718G","T28854C"],"N":["L194S"],"ORF1a":["R550C","E755K","T4087I"],"ORF1b":["D2183Y"],"ORF3a":["Y109C"]},"labels":{"aa":"N: L194S; ORF1a: R550C, E755K, T4087I; ORF1b: D2183Y; ORF3a: Y109C"}}},{"name":"B.1.389","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.389"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.389"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G8371T","C9430T","A15477T","C18395T","A20622T","G20623T","A20624T","C23730T","A26319G","G29044A"],"ORF1a":["Q2702H"],"ORF1b":["A1643V","K2385N","D2386F"],"S":["T723I"]},"labels":{"aa":"ORF1a: Q2702H; ORF1b: A1643V, K2385N, D2386F; S: T723I","spike_mutations":"T723I"}}},{"name":"B.1.480","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.480"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.480"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.699548721313477}},"branch_attrs":{"mutations":{"nuc":["C875T","A10904G","G25249T"],"ORF1a":["L204F","S3547G"],"S":["M1229I"]},"labels":{"aa":"ORF1a: L204F, S3547G; S: M1229I","spike_mutations":"M1229I"}}}]}]}]},{"name":"NODE_0000459","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.48314905166626}},"branch_attrs":{"mutations":{"nuc":["C1059T","A10323G","G25563T","G28842T"],"N":["S190I"],"ORF1a":["T265I","K3353R"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S190I; ORF1a: T265I, K3353R; ORF3a: Q57H"}},"children":[{"name":"B.1.361","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.361"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.361"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0868425369262695}},"branch_attrs":{"mutations":{"nuc":["A705G","G1463A","G11417T","C18167T","A21080G","G29779T"],"ORF1a":["D147G","G400S","V3718F"],"ORF1b":["P1567L","K2538R"]},"labels":{"aa":"ORF1a: D147G, G400S, V3718F; ORF1b: P1567L, K2538R"}}},{"name":"B.1.580","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.580"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.580"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.48314905166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000460","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{"nuc":["T15276A"]}},"children":[{"name":"B.1.568","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.568"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.568"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097565650939941}},"branch_attrs":{"mutations":{"nuc":["C5654T","C10450T","C12049T","C12455A","C16428T","C17483T","G25913A","G27916T"],"ORF1a":["L4064I"],"ORF1b":["T1339I"],"ORF3a":["G174D"],"ORF8":["G8V"]},"labels":{"aa":"ORF1a: L4064I; ORF1b: T1339I; ORF3a: G174D; ORF8: G8V"}}},{"name":"B.1.582","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.582"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.582"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{}}},{"name":"B.1.612","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.612"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.612"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000461","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.893455743789673}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.530","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.530"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.530"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G61T","A3291G","C11050T","G16935T","A19339G","C23604A","C26549T","T29471C"],"ORF1a":["Q1009R"],"ORF1b":["M1156I","S1958G"],"S":["P681H"]},"labels":{"aa":"ORF1a: Q1009R; ORF1b: M1156I, S1958G; S: P681H","spike_mutations":"P681H"}}},{"name":"NODE_0000462","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.436675548553467}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","A21768-","T21769-","G21770-","G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.415.1","node_attrs":{"div":29,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.415.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.415.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1150T","T7185C","C8251T","A11023T","A11217G","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C13458T","G15732T","T16348C","A16619G","A18410G","T19143C","A20268G","C21767-","C22286-","T22287-","T22288-","G22299C","G22599A","A23064C","C23604A","C24138A","C24507T","G26840T","G28178A","A28271-","G28302A","C28932T"],"N":["R10Q","A220V"],"ORF1a":["I2307T","N3651S","S4398L"],"ORF1b":["S961P","E1051G","Y1648C"],"ORF9b":["E7K"],"S":["H69-","V70-","L241-","R246T","R346K","N501T","P681H","T859N","S982L"]},"labels":{"aa":"N: R10Q, A220V; ORF1a: I2307T, N3651S, S4398L; ORF1b: S961P, E1051G, Y1648C; ORF9b: E7K; S: H69-, V70-, L241-, R246T, R346K, N501T, P681H, T859N, S982L","spike_mutations":"H69-, V70-, L241-, R246T, R346K, N501T, P681H, T859N, S982L"}}},{"name":"B.1.525","node_attrs":{"div":24,"clade_display":{"value":"21D (Eta)"},"Nextclade_pango":{"value":"B.1.525"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21D"},"clade_who":{"value":"Eta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.525"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"21D"},"placement_prior":{"value":-3.212512969970703}},"branch_attrs":{"mutations":{"nuc":["C1498T","A1807G","G2659A","C6285T","T8593C","C9565T","C11289-","G11291-","G11292-","C14407T","C18171T","A20724G","A21717G","C21762T","C21767-","T21992-","A21993-","T21994-","G23593C","T24224C","C24748T","T27205-","T27206-","T27207-","C28278-","T28279-","G28280-","C28308G","A28699G","G29543T"],"N":["S2-","D3Y","A12G"],"ORF1a":["T2007I","S3675-","G3676-","F3677-"],"ORF1b":["L314F"],"ORF6":["F2-"],"ORF9b":["H9D"],"S":["Q52R","A67V","H69-","V70-","Y144-","Q677H","F888L"]},"labels":{"aa":"N: S2-, D3Y, A12G; ORF1a: T2007I, S3675-, G3676-, F3677-; ORF1b: L314F; ORF6: F2-; ORF9b: H9D; S: Q52R, A67V, H69-, V70-, Y144-, Q677H, F888L","clade":"Eta","spike_mutations":"Q52R, A67V, H69-, V70-, Y144-, Q677H, F888L"}}},{"name":"NODE_0000463","node_attrs":{"div":30,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2407A","G5008T","C6633T","G8084A","C8311T","C9319T","C11289-","G11291-","G11292-","G11521T","C12473T","C14403T","C15324T","G19962A","C21637T","-21765T","-21766A","-21768A","-21769T","-21770G","T22191C","T22882G","T24194C","G24368A","C24378T","C24642T","G26211T","C26606T","G27459T","C28311T","G28875T"],"N":["P13L","S201I"],"ORF1a":["A2123V","E2607K","S3675-","G3676-","F3677-","M3752I"],"ORF7a":["E22D"],"ORF9b":["P10S"],"S":["I210T","N440K","D936N","S939F","T1027I"]},"labels":{"aa":"N: P13L, S201I; ORF1a: A2123V, E2607K, S3675-, G3676-, F3677-, M3752I; ORF7a: E22D; ORF9b: P10S; S: I210T, N440K, D936N, S939F, T1027I","spike_mutations":"I210T, N440K, D936N, S939F, T1027I"}},"children":[{"name":"B.1.619.1","node_attrs":{"div":38,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.619.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-27"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C19T","T5701C","A12051G","A21213G","T22738C","A28271-","C28441T","T28600C","C28957T"],"ORF1a":["K3929R"],"ORF9b":["S53L"]},"labels":{"aa":"ORF1a: K3929R; ORF9b: S53L"}}},{"name":"B.1.619","node_attrs":{"div":30,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.619"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-20"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000464","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.037975788116455}},"branch_attrs":{"mutations":{"nuc":["C1059T","C11916T","G25563T"],"ORF1a":["T265I","S3884L"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, S3884L; ORF3a: Q57H"}},"children":[{"name":"B.1.3","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C715T","A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"B.1.497","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.497"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.497"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A1G","C16650T","A20675T","G29179T"],"ORF1b":["Q2403L"]},"labels":{"aa":"ORF1b: Q2403L"}}},{"name":"B.1.509","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.509"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.509"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097174167633057}},"branch_attrs":{"mutations":{"nuc":["C1385T","G1738T","G3242A","C28087T"],"ORF1a":["H374Y","G993S"],"ORF8":["A65V"]},"labels":{"aa":"ORF1a: H374Y, G993S; ORF8: A65V"}}},{"name":"NODE_0000465","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8570423126220703}},"branch_attrs":{"mutations":{"nuc":["C18998T","G29540A"],"ORF1b":["A1844V"]},"labels":{"aa":"ORF1b: A1844V"}},"children":[{"name":"B.1.503","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.503"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.503"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25947C"],"ORF3a":["Q185H"]},"labels":{"aa":"ORF3a: Q185H"}}},{"name":"B.1.499","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.499"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.499"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["C28863T"],"N":["S197L"]},"labels":{"aa":"N: S197L"}}},{"name":"B.1.505","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.505"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.505"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C66A","C7768T","A8773G","C17304T","T24805C"]}}}]}]},{"name":"NODE_0000466","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.3400766849517822}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","C27964T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"ORF8":["S24L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; ORF8: S24L"}},"children":[{"name":"B.1.265","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.265"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.265"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.216925144195557}},"branch_attrs":{"mutations":{"nuc":["C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}}},{"name":"B.1.336","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.336"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.336"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.552525043487549}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}}},{"name":"B.1.426","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.426"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.426"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8291878700256348}},"branch_attrs":{"mutations":{"nuc":["T833C","A22320G"],"ORF1a":["F190L"],"S":["D253G"]},"labels":{"aa":"ORF1a: F190L; S: D253G","spike_mutations":"D253G"}}},{"name":"NODE_0000467","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.473392963409424}},"branch_attrs":{"mutations":{"nuc":["A18424G","G25907T"],"ORF1b":["N1653D"],"ORF3a":["G172V"]},"labels":{"aa":"ORF1b: N1653D; ORF3a: G172V"}},"children":[{"name":"B.1.2","node_attrs":{"div":13,"clade_display":{"value":"20G"},"Nextclade_pango":{"value":"B.1.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20G"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20G"},"placement_prior":{"value":-2.0290510654449463}},"branch_attrs":{"mutations":{"nuc":["C10319T","C21304T","C28472T","C28869T"],"N":["P67S","P199L"],"ORF1a":["L3352F"],"ORF1b":["R2613C"]},"labels":{"aa":"N: P67S, P199L; ORF1a: L3352F; ORF1b: R2613C","clade":"20G"}}},{"name":"B.1.596","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.596"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.596"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.473392963409424}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000468","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7301440238952637}},"branch_attrs":{"mutations":{"nuc":["C10319T"],"ORF1a":["L3352F"]},"labels":{"aa":"ORF1a: L3352F"}},"children":[{"name":"B.1.567","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.567"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.567"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.657745838165283}},"branch_attrs":{"mutations":{"nuc":["C11575T","A20262G","G21305A","C28868T"],"N":["P199S"],"ORF1b":["R2613H"]},"labels":{"aa":"N: P199S; ORF1b: R2613H"}}},{"name":"B.1.577","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.577"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.577"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8689005374908447}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"B.1.595","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.595"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.595"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7301440238952637}},"branch_attrs":{"mutations":{"nuc":["A1G"]}}},{"name":"NODE_0000469","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.712774276733398}},"branch_attrs":{"mutations":{"nuc":["G6052A","G19872T","G25855T","G29254T","G29474T"],"N":["D401Y"],"ORF3a":["D155Y"]},"labels":{"aa":"N: D401Y; ORF3a: D155Y"}},"children":[{"name":"B.1.588","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.588"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.588"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{"nuc":["C7600T","G7675C","C21621T","G22201T","G28975T","G29764T"],"N":["M234I"],"S":["T20I"]},"labels":{"aa":"N: M234I; S: T20I","spike_mutations":"T20I"}}},{"name":"B.1.587","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.587"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.587"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.289678573608398}},"branch_attrs":{"mutations":{"nuc":["T5122C","G20102T","C20117T","A22095G"],"ORF1b":["S2212I","T2217I"],"S":["D178G"]},"labels":{"aa":"ORF1b: S2212I, T2217I; S: D178G","spike_mutations":"D178G"}}}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.361743927001953}},"branch_attrs":{"mutations":{"nuc":["C15324T"]}},"children":[{"name":"B.1.146","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.146"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.146"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["C10833T","G28747T","G28917T","G29543T"],"N":["G215V"],"ORF1a":["A3523V"]},"labels":{"aa":"N: G215V; ORF1a: A3523V"}}},{"name":"B.1.149","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.149"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.149"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.820753574371338}},"branch_attrs":{"mutations":{"nuc":["G16846T"],"ORF1b":["D1127Y"]},"labels":{"aa":"ORF1b: D1127Y"}}},{"name":"B.1.147","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.147"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.147"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.988577127456665}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"B.1.210","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.210"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.210"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.527066707611084}},"branch_attrs":{"mutations":{"nuc":["A1C","C3634T"]}}},{"name":"B.1.212","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.212"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.212"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.869997978210449}},"branch_attrs":{"mutations":{"nuc":["C16428T"]}}},{"name":"B.1.221","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.221"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.221"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.022772789001465}},"branch_attrs":{"mutations":{"nuc":["C3602T","C6941T","C21855T","A25505G","G25906C","G25996T","C28651T","C28869T"],"N":["P199L"],"ORF1a":["H1113Y"],"ORF3a":["Q38R","G172R","V202L"],"S":["S98F"]},"labels":{"aa":"N: P199L; ORF1a: H1113Y; ORF3a: Q38R, G172R, V202L; S: S98F","spike_mutations":"S98F"}}},{"name":"B.1.219","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.219"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.219"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.373951435089111}},"branch_attrs":{"mutations":{"nuc":["T13A","C16193T","A22404T"],"ORF1b":["P909L"],"S":["E281V"]},"labels":{"aa":"ORF1b: P909L; S: E281V","spike_mutations":"E281V"}}},{"name":"B.1.620","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.620"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.620"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A22T","C1473T","G6236A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G17110T","T20049C","C21638T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21939C","T21992-","A21993-","T21994-","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","C22295T","C22498T","G22992A","G23012A","A23416T","C23604A","C24642T","G24914C","A28271T","T28297C","C28932T"],"N":["A220V"],"ORF1a":["T403I","V1991I","S3675-","G3676-","F3677-"],"ORF1b":["A1215S"],"ORF9b":["I5T"],"S":["P26S","H69-","V70-","V126A","Y144-","L241-","L242-","A243-","H245Y","S477N","E484K","P681H","T1027I","D1118H"]},"labels":{"aa":"N: A220V; ORF1a: T403I, V1991I, S3675-, G3676-, F3677-; ORF1b: A1215S; ORF9b: I5T; S: P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H","spike_mutations":"P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H"}}},{"name":"NODE_0000471","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.518583297729492}},"branch_attrs":{"mutations":{"nuc":["A4457G","C5907T","C12312T"],"ORF1a":["I1398V","T1881I","A4016V"]},"labels":{"aa":"ORF1a: I1398V, T1881I, A4016V"}},"children":[{"name":"B.1.214","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.518583297729492}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000472","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-7.461870193481445}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.214.1","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-02"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.2221879959106445}},"branch_attrs":{"mutations":{"nuc":["A481G","C5144T","C17304G","C17999T"],"ORF1b":["T1511I"]},"labels":{"aa":"ORF1b: T1511I"}}},{"name":"NODE_0000473","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C4891T","A15187G","C23709T","T27576C","G28280C","A28281T","T28282A","C28846T"],"N":["D3L"],"ORF1b":["R574G"],"S":["T716I"]},"labels":{"aa":"N: D3L; ORF1b: R574G; S: T716I","spike_mutations":"T716I"}},"children":[{"name":"B.1.214.2","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:29-276"},"partiallyAliased":{"value":"B.1.214.2"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-02"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9553585052490234}},"branch_attrs":{"mutations":{"nuc":["C22802A","T22912G","A25448-","A25449-","A25450-","T25451-","C25452-","A25453-","A25454-","G25455-","G25456-","A25457-","T25458-","G25459-","C25460-","T25461-","A25462-","C25463-","T25464-","C25465-","C25466-","T25467-","T25468-","C25469-","A25470-","G25471-","A25472-","T25473-","T25474-","T25475-"],"ORF3a":["E19-","I20-","K21-","D22-","A23-","T24-","P25-","S26-","D27-","F28-"],"S":["Q414K","N450K"]},"labels":{"aa":"ORF3a: E19-, I20-, K21-, D22-, A23-, T24-, P25-, S26-, D27-, F28-; S: Q414K, N450K","spike_mutations":"Q414K, N450K"}}},{"name":"B.1.214.3","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-01"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C673T","A11282-","G11283-","T11284-","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291T","A11430G","C21846T"],"ORF1a":["S3673-","L3674-","S3675-","G3676C","Y3722C"],"S":["T95I"]},"labels":{"aa":"ORF1a: S3673-, L3674-, S3675-, G3676C, Y3722C; S: T95I","spike_mutations":"T95I"}}}]}]}]}]},{"name":"NODE_0000474","node_attrs":{"div":7,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-3.818593740463257}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","C28887T"],"N":["T205I"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: T205I; ORF1a: T265I; ORF3a: Q57H","clade":"20C"}},"children":[{"name":"B.1.346","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.346"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.346"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["A12820G","C16762T","A17637G","C20762T"],"ORF1b":["L1099F","T2432I"]},"labels":{"aa":"ORF1b: L1099F, T2432I"}}},{"name":"B.1.433","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.433"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.433"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.620072364807129}},"branch_attrs":{"mutations":{"nuc":["C6843T","T11764C","T17040C","G29402T"],"N":["D377Y"],"ORF1a":["S2193F"]},"labels":{"aa":"N: D377Y; ORF1a: S2193F"}}},{"name":"B.1.626","node_attrs":{"div":29,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.626"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.626"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-25"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1914A","C2197T","C9142T","C9803T","C10416T","C10908T","G11222T","C13011T","C16961T","C21614T","C21758-","A21759-","T21760-","G21761-","C21762-","T21763-","A21764-","T21765-","A21766-","G22331A","G23012A","T23031C","A23064C","C24138A","T24364C","C25511T","C25583T","T26767G","C27434T","A28271-","G28280T","C29627T","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"M":["I82S"],"N":["D3Y"],"ORF1a":["R550H","S3384L","A3548V","V3653F","T4249I"],"ORF1b":["P1165L"],"ORF3a":["S40L","T64I"],"ORF7a":["T14I"],"S":["L18F","H66-","A67-","I68-","G257S","E484K","F490S","N501T","T859N"]},"labels":{"aa":"M: I82S; N: D3Y; ORF1a: R550H, S3384L, A3548V, V3653F, T4249I; ORF1b: P1165L; ORF3a: S40L, T64I; ORF7a: T14I; S: L18F, H66-, A67-, I68-, G257S, E484K, F490S, N501T, T859N","spike_mutations":"L18F, H66-, A67-, I68-, G257S, E484K, F490S, N501T, T859N"}}},{"name":"NODE_0000475","node_attrs":{"div":8,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.235102653503418}},"branch_attrs":{"mutations":{"nuc":["G17259T"],"ORF1b":["E1264D"]},"labels":{"aa":"ORF1b: E1264D"}},"children":[{"name":"B.1.375","node_attrs":{"div":14,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.375"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.375"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.301670551300049}},"branch_attrs":{"mutations":{"nuc":["T1171C","A5747G","C10789T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G24007A","C25844T","A26664G"],"M":["I48V"],"ORF1a":["T1828A"],"ORF3a":["T151I"],"S":["H69-","V70-"]},"labels":{"aa":"M: I48V; ORF1a: T1828A; ORF3a: T151I; S: H69-, V70-","spike_mutations":"H69-, V70-"}}},{"name":"B.1.596.1","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.596.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.596.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["C21780T","G25907T","G28857A"],"N":["R195K"],"ORF3a":["G172V"],"S":["T73I"]},"labels":{"aa":"N: R195K; ORF3a: G172V; S: T73I","spike_mutations":"T73I"}}}]},{"name":"NODE_0000476","node_attrs":{"div":8,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.433472633361816}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"B.1.630","node_attrs":{"div":36,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.630"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.630"},"totalAminoacidDeletions":{"value":14},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-13"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C629T","A1262G","C1627T","G4963T","A5040G","A5648C","C6730T","C6794T","C7768T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T17505C","C19602T","G21255T","C21588T","C21637T","G21969T","T21992-","A21993-","T21994-","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22995G","G23012C","C23525T","G24410A","C25498-","C25499-","G25500-","A25501-","T25502-","A25503-","C25504-","A25505-","A25506-","G25507-","C25508-","C25509-","T25510-","C25511-","A25512-","C25513-","T25514-","C25515-","C25516-","C25517-","T25518-","T25519-","T25520-","C25521-","T25563G","T27796C","C27889T","A28272G","C28512G","G29508A","C29739T"],"N":["P80R","S412N"],"ORF1a":["L122F","T333A","R1566S","Q1592R","K1795Q","A3209V","S3675-","G3676-","F3677-"],"ORF3a":["P36-","I37-","Q38-","A39-","S40-","L41-","P42-","F43-","H57Q"],"ORF7b":["L14S"],"ORF9b":["Q77E"],"S":["P9L","C136F","Y144-","A222V","L242-","A243-","T478R","E484Q","H655Y","D950N"]},"labels":{"aa":"N: P80R, S412N; ORF1a: L122F, T333A, R1566S, Q1592R, K1795Q, A3209V, S3675-, G3676-, F3677-; ORF3a: P36-, I37-, Q38-, A39-, S40-, L41-, P42-, F43-, H57Q; ORF7b: L14S; ORF9b: Q77E; S: P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N","spike_mutations":"P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N"}}},{"name":"21C","node_attrs":{"div":13,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["G17014T","G21600T","G22018T","C26681T","A28272T"],"ORF1b":["D1183Y"],"S":["S13I","W152C"]},"labels":{"aa":"ORF1b: D1183Y; S: S13I, W152C","clade":"Epsilon","spike_mutations":"S13I, W152C"}},"children":[{"name":"B.1.429","node_attrs":{"div":20,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1.429"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.429"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-2.493906021118164}},"branch_attrs":{"mutations":{"nuc":["C2395T","T2597C","C8947T","C12100T","A12878G","T24349C","G27890T"],"ORF1a":["I4205V"]},"labels":{"aa":"ORF1a: I4205V"}}},{"name":"B.1.427","node_attrs":{"div":17,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1.427"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.427"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-2.8388144969940186}},"branch_attrs":{"mutations":{"nuc":["G9738C","G13713A","C16394T","C29362T"],"ORF1a":["S3158T"],"ORF1b":["P976L"]},"labels":{"aa":"ORF1a: S3158T; ORF1b: P976L"}}}]}]},{"name":"NODE_0000478","node_attrs":{"div":18,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.885955572128296}},"branch_attrs":{"mutations":{"nuc":["G174T","G5230T","A10323G","A21801C","A22206G","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","G22813T","G23012A","A23063T","C23664T","C26456T","C28253T"],"E":["P71L"],"ORF1a":["K1655N","K3353R"],"S":["D80A","D215G","L241-","L242-","A243-","K417N","E484K","N501Y","A701V"]},"labels":{"aa":"E: P71L; ORF1a: K1655N, K3353R; S: D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V","clade":"Beta","spike_mutations":"D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V"}},"children":[{"name":"B.1.351.1","node_attrs":{"div":27,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-5.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["C11289G","G11291T","G11292A","T11293C","G11299T","C11300T","T11301A","A11302C","C22513A"],"ORF1a":["S3675C","G3676Y","K3678N","L3679Y"],"S":["N317K"]},"labels":{"aa":"ORF1a: S3675C, G3676Y, K3678N, L3679Y; S: N317K","spike_mutations":"N317K"}}},{"name":"NODE_0000479","node_attrs":{"div":19,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.237952470779419}},"branch_attrs":{"mutations":{"nuc":["C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}},"children":[{"name":"B.1.351","node_attrs":{"div":19,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.237952470779419}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000480","node_attrs":{"div":21,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-2.969865322113037}},"branch_attrs":{"mutations":{"nuc":["A2692T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C21614T"],"ORF1a":["S3675-","G3676-","F3677-"],"S":["L18F"]},"labels":{"aa":"ORF1a: S3675-, G3676-, F3677-; S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.351.5","node_attrs":{"div":31,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.5"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-20"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-4.056198596954346}},"branch_attrs":{"mutations":{"nuc":["C664T","G1463T","C16338T","C19019A","C24109T","C24334T","G25660A","C25844T","C26645T","A29406T"],"N":["E378V"],"ORF1a":["G400C"],"ORF1b":["P1851Q"],"ORF3a":["V90I","T151I"]},"labels":{"aa":"N: E378V; ORF1a: G400C; ORF1b: P1851Q; ORF3a: V90I, T151I"}}},{"name":"NODE_0000481","node_attrs":{"div":23,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A8052G","G10396T"],"ORF1a":["N2596S"]},"labels":{"aa":"ORF1a: N2596S"}},"children":[{"name":"B.1.351.2","node_attrs":{"div":24,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.2"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C10632T"],"ORF1a":["A3456V"]},"labels":{"aa":"ORF1a: A3456V"}}},{"name":"B.1.351.3","node_attrs":{"div":28,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.3"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-05"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-4.0184102058410645}},"branch_attrs":{"mutations":{"nuc":["T3G","C6402T","T7624C","C10615T","A16687G"],"ORF1a":["P2046L"],"ORF1b":["I1074V"]},"labels":{"aa":"ORF1a: P2046L; ORF1b: I1074V"}}}]}]}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":11,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.10436749458313}},"branch_attrs":{"mutations":{"nuc":["T445C","C6286T","G21255C","C22227T","C26801G","C28932T","G29645T"],"N":["A220V"],"S":["A222V"]},"labels":{"aa":"N: A220V; S: A222V","clade":"20E","spike_mutations":"A222V"}},"children":[{"name":"B.1.177","node_attrs":{"div":11,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.10436749458313}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.16","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.051562786102295}},"branch_attrs":{"mutations":{"nuc":["C28310A"],"N":["P13T"],"ORF9b":["H9Q"]},"labels":{"aa":"N: P13T; ORF9b: H9Q"}}},{"name":"B.1.177.18","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.176742076873779}},"branch_attrs":{"mutations":{"nuc":["A10323G","G23311C","G25440T","C27752T"],"ORF1a":["K3353R"],"ORF3a":["K16N"],"ORF7a":["T120I"],"S":["E583D"]},"labels":{"aa":"ORF1a: K3353R; ORF3a: K16N; ORF7a: T120I; S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.177.15","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.15"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.15"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.8122081756591797}},"branch_attrs":{"mutations":{"nuc":["C5170T","C10078T","G11132T","G11417T","G22051T","G29179T"],"ORF1a":["A3623S","V3718F"]},"labels":{"aa":"ORF1a: A3623S, V3718F"}}},{"name":"B.1.177.32","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.32"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.204561233520508}},"branch_attrs":{"mutations":{"nuc":["C5700T","C11152T"],"ORF1a":["A1812V"]},"labels":{"aa":"ORF1a: A1812V"}}},{"name":"B.1.177.73","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.73"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.0868425369262695}},"branch_attrs":{"mutations":{"nuc":["G1820A","A2473G","T7543C","C13671T","A24774T","C26060A"],"ORF1a":["G519S"],"ORF3a":["T223N"],"S":["Q1071L"]},"labels":{"aa":"ORF1a: G519S; ORF3a: T223N; S: Q1071L","spike_mutations":"Q1071L"}}},{"name":"B.1.177.75","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.75"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.15676212310791}},"branch_attrs":{"mutations":{"nuc":["A1C","T8284C"]}}},{"name":"NODE_0000483","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.143002986907959}},"branch_attrs":{"mutations":{"nuc":["C222T","T20661C","C29386T"]}},"children":[{"name":"B.1.177.44","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.44"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.074657917022705}},"branch_attrs":{"mutations":{"nuc":["G21468T"],"ORF1b":["M2667I"]},"labels":{"aa":"ORF1b: M2667I"}}},{"name":"NODE_0000484","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.473905324935913}},"branch_attrs":{"mutations":{"nuc":["C29366T"],"N":["P365S"]},"labels":{"aa":"N: P365S"}},"children":[{"name":"B.1.177.12","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.12"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.12"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.395730495452881}},"branch_attrs":{"mutations":{"nuc":["T24814C","G25757T"],"ORF3a":["R122I"]},"labels":{"aa":"ORF3a: R122I"}}},{"name":"B.1.177.35","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.877903938293457}},"branch_attrs":{"mutations":{"nuc":["T26966C"]}}}]}]},{"name":"NODE_0000485","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.9249725341796875}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}},"children":[{"name":"B.1.177.10","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.106119155883789}},"branch_attrs":{"mutations":{"nuc":["G28321A"],"ORF9b":["R13H"]},"labels":{"aa":"ORF9b: R13H"}}},{"name":"B.1.177.46","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.46"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.155553817749023}},"branch_attrs":{"mutations":{"nuc":["C9693T","C18508T","G29179T"],"ORF1a":["A3143V"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: A3143V; ORF1b: L1681F"}}},{"name":"NODE_0000486","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.44374942779541}},"branch_attrs":{"mutations":{"nuc":["C1513T","C22377T"],"S":["P272L"]},"labels":{"aa":"S: P272L","spike_mutations":"P272L"}},"children":[{"name":"B.1.177.82","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.82"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.837984561920166}},"branch_attrs":{"mutations":{"nuc":["G28378T","G29757T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.177.83","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.83"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.299724102020264}},"branch_attrs":{"mutations":{"nuc":["C2062T"]}}},{"name":"B.1.177.87","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.87"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.936094045639038}},"branch_attrs":{"mutations":{"nuc":["C28706T","C29095T"],"N":["H145Y"]},"labels":{"aa":"N: H145Y"}}}]}]},{"name":"NODE_0000487","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.161720037460327}},"branch_attrs":{"mutations":{"nuc":["C27944T"]}},"children":[{"name":"B.1.177.4","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.478666067123413}},"branch_attrs":{"mutations":{"nuc":["C66T","A1987G","G10870T","C25614T"]}}},{"name":"B.1.177.52","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.52"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.295442581176758}},"branch_attrs":{"mutations":{"nuc":["A1T","G5023T","C25047G"],"ORF1a":["M1586I"],"S":["P1162R"]},"labels":{"aa":"ORF1a: M1586I; S: P1162R","spike_mutations":"P1162R"}}},{"name":"B.1.177.81","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.81"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.399031639099121}},"branch_attrs":{"mutations":{"nuc":["C12119T","A21222T","C25889T"],"ORF1a":["P3952S"],"ORF3a":["S166L"]},"labels":{"aa":"ORF1a: P3952S; ORF3a: S166L"}}},{"name":"NODE_0000488","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.53"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.278008460998535}},"branch_attrs":{"mutations":{"nuc":["C2973T","G9805T"],"ORF1a":["A903V"]},"labels":{"aa":"ORF1a: A903V"}},"children":[{"name":"B.1.177.53","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.53"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.278008460998535}},"branch_attrs":{"mutations":{}}},{"name":"W.1","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"W.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.53.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-5.000475883483887}},"branch_attrs":{"mutations":{"nuc":["C17463T","C17676T","T24799C","G25785T"],"ORF3a":["W131C"]},"labels":{"aa":"ORF3a: W131C"}}}]},{"name":"NODE_0000489","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.131291389465332}},"branch_attrs":{"mutations":{"nuc":["G204T"]}},"children":[{"name":"B.1.177.21","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.21"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.21"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.0787036418914795}},"branch_attrs":{"mutations":{"nuc":["T16242A"]}}},{"name":"B.1.177.77","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.77"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.045211315155029}},"branch_attrs":{"mutations":{"nuc":["T3592C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"NODE_0000490","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.644140243530273}},"branch_attrs":{"mutations":{"nuc":["C9745T"]}},"children":[{"name":"B.1.177.54","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.54"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.9744465351104736}},"branch_attrs":{"mutations":{"nuc":["C23644T","T25878C","G25879A","A25881T"],"ORF3a":["V163I"]},"labels":{"aa":"ORF3a: V163I"}}},{"name":"NODE_0000491","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.353252410888672}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"ORF1a":["A2554V"]},"labels":{"aa":"ORF1a: A2554V"}},"children":[{"name":"B.1.177.56","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.56"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.353252410888672}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.57","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.57"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.707308292388916}},"branch_attrs":{"mutations":{"nuc":["C6807T"],"ORF1a":["T2181I"]},"labels":{"aa":"ORF1a: T2181I"}}}]}]},{"name":"NODE_0000492","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-2.56699800491333}},"branch_attrs":{"mutations":{"nuc":["C21614T"],"S":["L18F"]},"labels":{"aa":"S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.177.5","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.151096820831299}},"branch_attrs":{"mutations":{"nuc":["T24769C","C25460T"],"ORF3a":["A23V"]},"labels":{"aa":"ORF3a: A23V"}}},{"name":"B.1.177.60","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.60"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.3496036529541016}},"branch_attrs":{"mutations":{"nuc":["A1G","G25621T"],"ORF3a":["V77F"]},"labels":{"aa":"ORF3a: V77F"}}},{"name":"B.1.177.62","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.62"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.26824951171875}},"branch_attrs":{"mutations":{"nuc":["C7195T","C21714T","G24368T","G25855T"],"ORF3a":["D155Y"],"S":["T51I","D936Y"]},"labels":{"aa":"ORF3a: D155Y; S: T51I, D936Y","spike_mutations":"T51I, D936Y"}}},{"name":"B.1.177.7","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.7"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.4441723823547363}},"branch_attrs":{"mutations":{"nuc":["C15480T"]}}},{"name":"B.1.177.8","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.112912654876709}},"branch_attrs":{"mutations":{"nuc":["G8179T"]}}},{"name":"B.1.177.86","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.86"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.4548091888427734}},"branch_attrs":{"mutations":{"nuc":["C6040T","G26801T","G27870T"],"ORF7b":["E39*"]},"labels":{"aa":"ORF7b: E39*"}}}]}]}]}]},{"name":"NODE_0000493","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.2655062675476074}},"branch_attrs":{"mutations":{"nuc":["A20268G"]}},"children":[{"name":"B.1.189","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.189"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.189"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0477776527404785}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.192","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.192"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.192"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.362252235412598}},"branch_attrs":{"mutations":{"nuc":["C11833T"]}}},{"name":"B.1.237","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.237"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.237"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.8359174728393555}},"branch_attrs":{"mutations":{"nuc":["G2164C"],"ORF1a":["E633D"]},"labels":{"aa":"ORF1a: E633D"}}},{"name":"B.1.381","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.381"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.381"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.034161567687988}},"branch_attrs":{"mutations":{"nuc":["C355T","C4093T"]}}},{"name":"B.1.420","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.420"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.420"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.049466133117676}},"branch_attrs":{"mutations":{"nuc":["T23443C"]}}},{"name":"B.1.417","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.417"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.417"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.064149856567383}},"branch_attrs":{"mutations":{"nuc":["T5422C","C7051T","G7743T","C12880T"],"ORF1a":["S2493I"]},"labels":{"aa":"ORF1a: S2493I"}}},{"name":"B.1.609","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.609"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.609"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.865211248397827}},"branch_attrs":{"mutations":{"nuc":["C4582T"]}}},{"name":"B.1.600","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.600"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.600"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.995730876922607}},"branch_attrs":{"mutations":{"nuc":["A5G","A6G","G7A","C5784T","C27982T"],"ORF1a":["T1840I"],"ORF8":["P30L"]},"labels":{"aa":"ORF1a: T1840I; ORF8: P30L"}}},{"name":"NODE_0000494","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.637956142425537}},"branch_attrs":{"mutations":{"nuc":["A1C","C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}},"children":[{"name":"B.1.416","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.416"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.27862024307251}},"branch_attrs":{"mutations":{"nuc":["C1625T"],"ORF1a":["L454F"]},"labels":{"aa":"ORF1a: L454F"}}},{"name":"B.1.416.1","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.416.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.302814483642578}},"branch_attrs":{"mutations":{"nuc":["C25731T"]}}}]},{"name":"NODE_0000495","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{"nuc":["A1G","T7767C","C8047T","C17104T","C22879A","G29734C"],"ORF1a":["I2501T"],"ORF1b":["H1213Y"],"S":["N439K"]},"labels":{"aa":"ORF1a: I2501T; ORF1b: H1213Y; S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.258","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{}}},{"name":"B.1.258.3","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9645659923553467}},"branch_attrs":{"mutations":{"nuc":["G1464A","A10978T","G18803T","T20799C"],"ORF1a":["G400D"],"ORF1b":["S1779I"]},"labels":{"aa":"ORF1a: G400D; ORF1b: S1779I"}}},{"name":"NODE_0000496","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9934825897216797}},"branch_attrs":{"mutations":{"nuc":["C27800A"]}},"children":[{"name":"B.1.258.14","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.14"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.14"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.224915027618408}},"branch_attrs":{"mutations":{"nuc":["G1A","C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}}},{"name":"NODE_0000497","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.193143367767334}},"branch_attrs":{"mutations":{"nuc":["G12988T","G15598A","G18028T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T24910C","T26972C"],"ORF1a":["M4241I"],"ORF1b":["V711I","A1521S"],"S":["H69-","V70-"]},"labels":{"aa":"ORF1a: M4241I; ORF1b: V711I, A1521S; S: H69-, V70-","spike_mutations":"H69-, V70-"}},"children":[{"name":"B.1.258.11","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.11"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.11"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.367208242416382}},"branch_attrs":{"mutations":{"nuc":["C12455T","C20451T"],"ORF1a":["L4064F"]},"labels":{"aa":"ORF1a: L4064F"}}},{"name":"B.1.258.17","node_attrs":{"div":25,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.17"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.17"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.194498300552368}},"branch_attrs":{"mutations":{"nuc":["C829T","C14697T","C16394T","C18176T","G19398T","C22127T","G23876A","G25947T"],"ORF1b":["P976L","P1570L","E1977D"],"ORF3a":["Q185H"],"S":["L189F","V772I"]},"labels":{"aa":"ORF1b: P976L, P1570L, E1977D; ORF3a: Q185H; S: L189F, V772I","spike_mutations":"L189F, V772I"}}}]}]}]},{"name":"NODE_0000498","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0564932823181152}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.232","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.232"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.232"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8151824474334717}},"branch_attrs":{"mutations":{"nuc":["G27987T"],"ORF8":["V32L"]},"labels":{"aa":"ORF8: V32L"}}},{"name":"B.1.236","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.236"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.236"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.487241744995117}},"branch_attrs":{"mutations":{"nuc":["G11842A","A12759G","G18292T"],"ORF1a":["D4165G"],"ORF1b":["A1609S"]},"labels":{"aa":"ORF1a: D4165G; ORF1b: A1609S"}}},{"name":"B.1.234","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.234"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.234"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.2366039752960205}},"branch_attrs":{"mutations":{"nuc":["G2258A","A6441G","C8140T","A9204G"],"ORF1a":["V665I","K2059R","D2980G"]},"labels":{"aa":"ORF1a: V665I, K2059R, D2980G"}}},{"name":"B.1.239","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.239"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.239"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.171220779418945}},"branch_attrs":{"mutations":{"nuc":["G16741A"],"ORF1b":["V1092I"]},"labels":{"aa":"ORF1b: V1092I"}}},{"name":"B.1.243","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.243"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.243"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.002568006515503}},"branch_attrs":{"mutations":{"nuc":["T24076C"]}}},{"name":"B.1.241","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.241"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.241"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9270756244659424}},"branch_attrs":{"mutations":{"nuc":["C11575T"]}}},{"name":"B.1.398","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.398"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.398"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.523491859436035}},"branch_attrs":{"mutations":{"nuc":["G4136A","C11224T","C12295A","C21846T"],"ORF1a":["V1291I"],"S":["T95I"]},"labels":{"aa":"ORF1a: V1291I; S: T95I","spike_mutations":"T95I"}}},{"name":"B.1.396","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.396"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.396"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1255927085876465}},"branch_attrs":{"mutations":{"nuc":["C1191T","C9521A","C24904T","G29422T","A29567G"],"ORF1a":["P309L","L3086I"]},"labels":{"aa":"ORF1a: P309L, L3086I"}}},{"name":"B.1.397","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.397"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.397"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.8025803565979}},"branch_attrs":{"mutations":{"nuc":["G1135T"],"ORF1a":["K290N"]},"labels":{"aa":"ORF1a: K290N"}}},{"name":"B.1.400","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.400"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.400"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.656111001968384}},"branch_attrs":{"mutations":{"nuc":["G19969A"],"ORF1b":["A2168T"]},"labels":{"aa":"ORF1b: A2168T"}}},{"name":"B.1.399","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.399"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.399"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.259310722351074}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}}},{"name":"B.1.409","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.409"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.409"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.119840621948242}},"branch_attrs":{"mutations":{"nuc":["G3527A","G5015A","A5877G","G8017T","C11008T","C20283T","C25714T","G25855T","C27434T","C27998T"],"ORF1a":["D1088N","V1584M","N1871S"],"ORF3a":["L108F","D155Y"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: D1088N, V1584M, N1871S; ORF3a: L108F, D155Y; ORF7a: T14I"}}},{"name":"B.1.402","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.402"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.402"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0817766189575195}},"branch_attrs":{"mutations":{"nuc":["C4633T","T14643C","C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"B.1.551","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.551"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.551"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.050684928894043}},"branch_attrs":{"mutations":{"nuc":["C3738T","C23604G"],"ORF1a":["P1158L"],"S":["P681R"]},"labels":{"aa":"ORF1a: P1158L; S: P681R","spike_mutations":"P681R"}}},{"name":"B.1.558","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.558"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.558"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.163711071014404}},"branch_attrs":{"mutations":{"nuc":["C1288T"]}}},{"name":"NODE_0000499","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6818833351135254}},"branch_attrs":{"mutations":{"nuc":["C18486T","T22162C"]}},"children":[{"name":"B.1.240","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.240"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6818833351135254}},"branch_attrs":{"mutations":{}}},{"name":"B.1.240.1","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.240.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-8.3259916305542}},"branch_attrs":{"mutations":{"nuc":["G10610T","G10870T","G11335T","C14262T","G29494A"],"ORF1a":["V3449F"]},"labels":{"aa":"ORF1a: V3449F"}}}]},{"name":"NODE_0000500","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.489668369293213}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"B.1.404","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.404"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.404"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["G5572T","G7042T","A12644G","T16743C","G19086T","G22992A"],"ORF1a":["M1769I","M2259I","I4127V"],"ORF1b":["K1873N"],"S":["S477N"]},"labels":{"aa":"ORF1a: M1769I, M2259I, I4127V; ORF1b: K1873N; S: S477N","spike_mutations":"S477N"}}},{"name":"B.1.561","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.561"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.561"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6974472999572754}},"branch_attrs":{"mutations":{"nuc":["G2516T","A5999G","C18693T","G21974T","T25577C","G28975T"],"N":["M234I"],"ORF1a":["V751L","I1912V"],"ORF3a":["I62T"],"S":["D138Y"]},"labels":{"aa":"N: M234I; ORF1a: V751L, I1912V; ORF3a: I62T; S: D138Y","spike_mutations":"D138Y"}}}]}]}]},{"name":"NODE_0000501","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.725203275680542}},"branch_attrs":{"mutations":{"nuc":["C18877T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.111","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.111"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.111"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.209517478942871}},"branch_attrs":{"mutations":{"nuc":["C10507T"]}}},{"name":"B.1.170","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.170"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.170"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.725203275680542}},"branch_attrs":{"mutations":{}}},{"name":"B.1.436","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.436"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.436"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.123165607452393}},"branch_attrs":{"mutations":{"nuc":["C28890T","T29710A"],"N":["S206F"]},"labels":{"aa":"N: S206F"}}},{"name":"B.1.438","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.438"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.438"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.653039455413818}},"branch_attrs":{"mutations":{"nuc":["A1154G","G29474T"],"N":["D401Y"],"ORF1a":["M297V"]},"labels":{"aa":"N: D401Y; ORF1a: M297V"}}},{"name":"B.1.441","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.441"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.441"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.796085357666016}},"branch_attrs":{"mutations":{"nuc":["T8296C","G28690T"],"N":["L139F"]},"labels":{"aa":"N: L139F"}}},{"name":"NODE_0000502","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.096360206604004}},"branch_attrs":{"mutations":{"nuc":["A28272G","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}},"children":[{"name":"B.1.438.1","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.438.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.438.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.225435256958008}},"branch_attrs":{"mutations":{"nuc":["A1154G","C8152T","A12121G","G23587T","G25677T","G29474T"],"N":["D401Y"],"ORF1a":["M297V"],"ORF3a":["L95F"],"S":["Q675H"]},"labels":{"aa":"N: D401Y; ORF1a: M297V; ORF3a: L95F; S: Q675H","spike_mutations":"Q675H"}}},{"name":"B.1.625","node_attrs":{"div":26,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.625"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:4-122"},"partiallyAliased":{"value":"B.1.625"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-19"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["G521T","C2306T","A4220G","C5730T","C6401T","A10323G","C10775T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12730G","A13712G","C16694T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","T21992-","A21993-","T21994-","C22033A","T22882G","G23012A","G24410A","G25244T","T26767C","A27721G","A27897-","A27898-","A27899-","T27900-","T27901-"],"M":["I82T"],"ORF1a":["V86F","L681F","K1319E","T1822I","P2046S","K3353R","P3504S","S3675-","G3676-","F3677-"],"ORF1b":["K82R","T1076I"],"ORF7a":["I110V"],"ORF8":["K2-","F3-"],"S":["H69-","V70-","T95I","Y144-","F157L","N440K","E484K","D950N","V1228L"]},"labels":{"aa":"M: I82T; ORF1a: V86F, L681F, K1319E, T1822I, P2046S, K3353R, P3504S, S3675-, G3676-, F3677-; ORF1b: K82R, T1076I; ORF7a: I110V; ORF8: K2-, F3-; S: H69-, V70-, T95I, Y144-, F157L, N440K, E484K, D950N, V1228L","spike_mutations":"H69-, V70-, T95I, Y144-, F157L, N440K, E484K, D950N, V1228L"}}}]},{"name":"NODE_0000503","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.250260353088379}},"branch_attrs":{"mutations":{"nuc":["C7765T","C17690T"],"ORF1b":["S1408L"]},"labels":{"aa":"ORF1b: S1408L"}},"children":[{"name":"B.1.9.5","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.9.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.250260353088379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.9","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.9"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.655849933624268}},"branch_attrs":{"mutations":{"nuc":["C2113T"]}}}]},{"name":"NODE_0000504","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.290716171264648}},"branch_attrs":{"mutations":{"nuc":["C10029T","A21993-","A23063T","C23604A","A26492T","C28887T"],"N":["T205I"],"ORF1a":["T3255I"],"S":["Y144-","N501Y","P681H"]},"labels":{"aa":"N: T205I; ORF1a: T3255I; S: Y144-, N501Y, P681H","spike_mutations":"Y144-, N501Y, P681H"}},"children":[{"name":"B.1.640.1","node_attrs":{"div":46,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.640.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.640.1"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C601T","C1191T","A1620G","C2416T","C2455T","G6622T","C9711T","G9756A","T11418C","C11956T","C16575T","C16869T","T18877C","C20283T","C21588T","G21848C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","T21994-","G22132T","T22191C","A22600C","A22743G","T22907A","T23030C","T23031G","C24138A","G24368C","C25487T","T26767C","C27513T","C27807T","C27972T","A28271-","T28297C","G28337T","T29377C","G29405C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","G29779T"],"M":["I82T"],"N":["D22Y","E378Q"],"ORF1a":["P309L","E452G","L2119F","S3149F","R3164H","V3718A"],"ORF3a":["T32I"],"ORF8":["Q27*"],"ORF9b":["I5T","Q18H"],"S":["P9L","E96Q","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","R190S","I210T","R346S","N394S","Y449N","F490R","T859N","D936H"]},"labels":{"aa":"M: I82T; N: D22Y, E378Q; ORF1a: P309L, E452G, L2119F, S3149F, R3164H, V3718A; ORF3a: T32I; ORF8: Q27*; ORF9b: I5T, Q18H; S: P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, R190S, I210T, R346S, N394S, Y449N, F490R, T859N, D936H","spike_mutations":"P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, R190S, I210T, R346S, N394S, Y449N, F490R, T859N, D936H"}}},{"name":"NODE_0000505","node_attrs":{"div":29,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-3.4022557735443115}},"branch_attrs":{"mutations":{"nuc":["A3428G","C4878T","C6037T","A11451G","A13057T","C17491T","T19035C","C20148T","C21846T","-21993C","T21995A","G22599A","G23012A","G24410A","G26158-","T26159-","T26160-","A26161-","C27925A","C28005T","C28093T","A28272T"],"ORF1a":["T1055A","T1538I","Q3729R"],"ORF1b":["P1342S"],"ORF3a":["V256-","N257-"],"ORF8":["T11K","P38S","S67F"],"S":["T95I","-144S","Y145N","R346K","E484K","D950N"]},"labels":{"aa":"ORF1a: T1055A, T1538I, Q3729R; ORF1b: P1342S; ORF3a: V256-, N257-; ORF8: T11K, P38S, S67F; S: T95I, -144S, Y145N, R346K, E484K, D950N","clade":"Mu","spike_mutations":"T95I, -144S, Y145N, R346K, E484K, D950N"}},"children":[{"name":"B.1.621","node_attrs":{"div":29,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-23"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-3.4022557735443115}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":31,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.116074562072754}},"branch_attrs":{"mutations":{"nuc":["C5192T","C17707T"],"ORF1b":["P1414S"]},"labels":{"aa":"ORF1b: P1414S"}},"children":[{"name":"B.1.621.2","node_attrs":{"div":39,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-05"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["T177C","C2700T","T22907A","G23311T","G26959A","A27675C","G29736A","G29779T"],"M":["R146H"],"ORF1a":["T812I"],"ORF7a":["Q94H"],"S":["Y449N","E583D"]},"labels":{"aa":"M: R146H; ORF1a: T812I; ORF7a: Q94H; S: Y449N, E583D","spike_mutations":"Y449N, E583D"}}},{"name":"NODE_0000507","node_attrs":{"div":38,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.1"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{"nuc":["A6704G","C9120T","C20402T","T22384A","G26167T","C28657T","T29748C"],"ORF1a":["N2147D","T2952I"],"ORF1b":["S2312L"]},"labels":{"aa":"ORF1a: N2147D, T2952I; ORF1b: S2312L"}},"children":[{"name":"B.1.621.1","node_attrs":{"div":38,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.1"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-30"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{}}},{"name":"BB.2","node_attrs":{"div":42,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"BB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.1.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A6708G","C15963T","C24378T","C29409T"],"N":["T379I"],"ORF1a":["K2148R"],"S":["S939F"]},"labels":{"aa":"N: T379I; ORF1a: K2148R; S: S939F","spike_mutations":"S939F"}}}]}]}]}]},{"name":"NODE_0000508","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0052971839904785}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}},"children":[{"name":"B.1.465","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.465"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.465"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.766111373901367}},"branch_attrs":{"mutations":{"nuc":["G24197T"],"S":["A879S"]},"labels":{"aa":"S: A879S","spike_mutations":"A879S"}}},{"name":"B.1.462","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.462"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.462"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.589012622833252}},"branch_attrs":{"mutations":{"nuc":["C3811T"]}}},{"name":"B.1.468","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.468"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.468"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.633845806121826}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}}},{"name":"B.1.470","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.470"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.470"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.864387512207031}},"branch_attrs":{"mutations":{"nuc":["C14120T"],"ORF1b":["P218L"]},"labels":{"aa":"ORF1b: P218L"}}},{"name":"B.1.471","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.471"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.471"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.839450836181641}},"branch_attrs":{"mutations":{"nuc":["C16915T","T24202C"]}}},{"name":"B.1.469","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.469"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.469"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.699270725250244}},"branch_attrs":{"mutations":{"nuc":["A12075G","A21137G","C28866T"],"N":["T198I"],"ORF1a":["N3937S"],"ORF1b":["K2557R"]},"labels":{"aa":"N: T198I; ORF1a: N3937S; ORF1b: K2557R"}}},{"name":"B.1.523","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.523"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.523"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.353262901306152}},"branch_attrs":{"mutations":{"nuc":["G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"NODE_0000509","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.896757125854492}},"branch_attrs":{"mutations":{"nuc":["C4543T","G5629T","G9526T","C11497T","G13993T","G15766T","A16889G","G17019T","G22992A","C25710T","T26876C","G28975C","G29399A"],"N":["M234I","A376T"],"ORF1a":["M3087I"],"ORF1b":["A176S","V767L","K1141R","E1184D"],"S":["S477N"]},"labels":{"aa":"N: M234I, A376T; ORF1a: M3087I; ORF1b: A176S, V767L, K1141R, E1184D; S: S477N","spike_mutations":"S477N"}},"children":[{"name":"B.1.160","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.160"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.896757125854492}},"branch_attrs":{"mutations":{}}},{"name":"B.1.160.16","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.160.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.024462699890137}},"branch_attrs":{"mutations":{"nuc":["C27434T","C27964T","G29557T"],"ORF7a":["T14I"],"ORF8":["S24L"]},"labels":{"aa":"ORF7a: T14I; ORF8: S24L"}}}]},{"name":"NODE_0000510","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.83497428894043}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.466.1","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["A3423G","C6318A","C15026T","A19960G","C22879A","G25526T","C25553T","C26111T","A29019G","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K249R"],"ORF1a":["K1053R","P2018Q"],"ORF1b":["A520V","T2165A"],"ORF3a":["W45L","A54V","P240L"],"S":["N439K"]},"labels":{"aa":"N: K249R; ORF1a: K1053R, P2018Q; ORF1b: A520V, T2165A; ORF3a: W45L, A54V, P240L; S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.466","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.83497428894043}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000511","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.037178993225098}},"branch_attrs":{"mutations":{"nuc":["C5184T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"B.1.459","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.459"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.459"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.037178993225098}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000512","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.371043682098389}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22879A","C28887T"],"N":["T205I"],"ORF1a":["T1168I"],"S":["N439K"]},"labels":{"aa":"N: T205I; ORF1a: T1168I; S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.466.2","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.371043682098389}},"branch_attrs":{"mutations":{"nuc":["A29897T","A29898G","A29899G","A29902G"]}}},{"name":"NODE_0000513","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7382190227508545}},"branch_attrs":{"mutations":{"nuc":["C683T","C3096T","C11195T","C12880T","C17012T","T22219C","C23604G","C29718T","C29743T"],"ORF1a":["S944L","L3644F"],"ORF1b":["S1182L"],"S":["P681R"]},"labels":{"aa":"ORF1a: S944L, L3644F; ORF1b: S1182L; S: P681R","spike_mutations":"P681R"}},"children":[{"name":"AU.2","node_attrs":{"div":24,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"AU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-30"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.538212776184082}},"branch_attrs":{"mutations":{"nuc":["A11117G","C12439T","G20002T","G25314T"],"ORF1a":["I3618V"],"ORF1b":["D2179Y"],"S":["G1251V"]},"labels":{"aa":"ORF1a: I3618V; ORF1b: D2179Y; S: G1251V","spike_mutations":"G1251V"}}},{"name":"AU.3","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"AU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-30"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.585629463195801}},"branch_attrs":{"mutations":{"nuc":["C8109T","C19586T","G29315C"],"N":["D348H"],"ORF1a":["T2615I"],"ORF1b":["T2040I"]},"labels":{"aa":"N: D348H; ORF1a: T2615I; ORF1b: T2040I"}}}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.642129898071289}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36.19","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.19"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.19"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.078061103820801}},"branch_attrs":{"mutations":{"nuc":["A1C","G28086T","C29614T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"B.1.456","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.456"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.456"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.642129898071289}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000515","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}},"children":[{"name":"B.1.36","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.1","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.350651741027832}},"branch_attrs":{"mutations":{"nuc":["C11224T","C11941T","C12043T"]}}},{"name":"B.1.36.10","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.16","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.127452373504639}},"branch_attrs":{"mutations":{"nuc":["A1T","G25494T"]}}},{"name":"B.1.36.22","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.22"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.22"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1283345222473145}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"B.1.36.29","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.29"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8214738368988037}},"branch_attrs":{"mutations":{"nuc":["C3267T","C21034T","G26173T","G28183T","T28277C"],"N":["S2P"],"ORF1a":["T1001I"],"ORF1b":["L2523F"],"ORF3a":["E261*"],"ORF8":["S97I"]},"labels":{"aa":"N: S2P; ORF1a: T1001I; ORF1b: L2523F; ORF3a: E261*; ORF8: S97I"}}},{"name":"B.1.36.24","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.24"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.24"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.737071990966797}},"branch_attrs":{"mutations":{"nuc":["G22201T"]}}},{"name":"B.1.36.31","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.31"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1722T","A8512G","T9877C","G11222T","C12616T","C15738T","A21868T","C22227T","C25463T","G27561T","C28253T","C29095T"],"ORF1a":["A486V","V3653F"],"ORF3a":["T24I"],"S":["R102S","A222V"]},"labels":{"aa":"ORF1a: A486V, V3653F; ORF3a: T24I; S: R102S, A222V","spike_mutations":"R102S, A222V"}}},{"name":"B.1.36.35","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.654303073883057}},"branch_attrs":{"mutations":{"nuc":["G25440T"],"ORF3a":["K16N"]},"labels":{"aa":"ORF3a: K16N"}}},{"name":"B.1.36.7","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.7"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.544944763183594}},"branch_attrs":{"mutations":{"nuc":["A11211G","A22190-","T22191-","T22192-"],"ORF1a":["Y3649C"],"S":["I210-"]},"labels":{"aa":"ORF1a: Y3649C; S: I210-","spike_mutations":"I210-"}}},{"name":"B.1.36.8","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.073090076446533}},"branch_attrs":{"mutations":{"nuc":["A1T","C2836T"]}}},{"name":"B.1.36.9","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.9"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.9"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["G2035T","C2523T","G3994A","C5730T","C9924T","G11083T","C11109T","A22190-","T22191-","T22192-","C24138A"],"ORF1a":["L590F","T753I","T1822I","A3220V","L3606F","A3615V"],"S":["I210-","T859N"]},"labels":{"aa":"ORF1a: L590F, T753I, T1822I, A3220V, L3606F, A3615V; S: I210-, T859N","spike_mutations":"I210-, T859N"}}},{"name":"NODE_0000516","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.4276256561279297}},"branch_attrs":{"mutations":{"nuc":["T1947C"],"ORF1a":["V561A"]},"labels":{"aa":"ORF1a: V561A"}},"children":[{"name":"B.1.36.36","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8934714794158936}},"branch_attrs":{"mutations":{"nuc":["C2668T","G4136T","C12141T","C19512T","C28292A","G29179T"],"N":["Q7K"],"ORF1a":["V1291F","T3959I"]},"labels":{"aa":"N: Q7K; ORF1a: V1291F, T3959I"}}},{"name":"B.1.36.38","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.38"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.2723917961120605}},"branch_attrs":{"mutations":{"nuc":["G22918T"]}}},{"name":"NODE_0000517","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.259945392608643}},"branch_attrs":{"mutations":{"nuc":["C29555T"]}},"children":[{"name":"B.1.36.18","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8423047065734863}},"branch_attrs":{"mutations":{"nuc":["G8027T","G15438T","C18981T","G21785C","C28093T"],"ORF1a":["V2588F"],"ORF1b":["M657I"],"ORF8":["S67F"],"S":["G75R"]},"labels":{"aa":"ORF1a: V2588F; ORF1b: M657I; ORF8: S67F; S: G75R","spike_mutations":"G75R"}}},{"name":"NODE_0000518","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}},"children":[{"name":"B.1.36.17","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.17"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.17"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.39","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2319C","C6573T","C9936A","C15981T","C25904T"],"ORF1a":["F685S","S2103F","T3224N"],"ORF3a":["S171L"]},"labels":{"aa":"ORF1a: F685S, S2103F, T3224N; ORF3a: S171L"}}}]}]}]}]}]}]}]},{"name":"NODE_0000519","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9009342193603516}},"branch_attrs":{"mutations":{"nuc":["G210T","T22917G","C23604G","T27638C","G28881T","G29402T","G29742T"],"N":["R203M","D377Y"],"ORF7a":["V82A"],"S":["T19R","L452R","P681R"]},"labels":{"aa":"N: R203M, D377Y; ORF7a: V82A; S: T19R, L452R, P681R","spike_mutations":"T19R, L452R, P681R"}},"children":[{"name":"B.1.617.3","node_attrs":{"div":22,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["C835T","C7296T","C8208T","G10634T","C11322T","C16293T","C21618G","G23012C","T27384C","C27970T","C28472T"],"N":["P67S"],"ORF1a":["A2344V","T2648I","A3457S","A3686V"],"ORF8":["T26I"],"S":["E484Q"]},"labels":{"aa":"N: P67S; ORF1a: A2344V, T2648I, A3457S, A3686V; ORF8: T26I; S: E484Q","spike_mutations":"E484Q"}}},{"name":"internal_d736","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.266930103302002}},"branch_attrs":{"mutations":{"nuc":["G21987A","C25469T"],"ORF3a":["S26L"],"S":["G142D"]},"labels":{"aa":"ORF3a: S26L; S: G142D","spike_mutations":"G142D"}},"children":[{"name":"B.1.617.1","node_attrs":{"div":25,"clade_display":{"value":"21B (Kappa)"},"Nextclade_pango":{"value":"B.1.617.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21B"},"clade_who":{"value":"Kappa"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"21B"},"placement_prior":{"value":-3.281346321105957}},"branch_attrs":{"mutations":{"nuc":["C3457T","C4965T","A11201G","G17523T","A20396G","T21895C","G22022A","G23012C","C26681T","T26767G"],"M":["I82S"],"ORF1a":["T1567I","T3646A"],"ORF1b":["M1352I","K2310R"],"S":["R19T","E154K","E484Q"]},"labels":{"aa":"M: I82S; ORF1a: T1567I, T3646A; ORF1b: M1352I, K2310R; S: R19T, E154K, E484Q","clade":"Kappa","spike_mutations":"R19T, E154K, E484Q"}}},{"name":"NODE_0000521","node_attrs":{"div":19,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.944439172744751}},"branch_attrs":{"mutations":{"nuc":["C21618G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22995A","G24410A","T26767C","C27752T","A28271-","A28461G"],"M":["I82T"],"N":["D63G"],"ORF7a":["T120I"],"ORF9b":["T60A"],"S":["E156-","F157-","R158G","T478K","D950N"]},"labels":{"aa":"M: I82T; N: D63G; ORF7a: T120I; ORF9b: T60A; S: E156-, F157-, R158G, T478K, D950N","clade":"Delta","spike_mutations":"E156-, F157-, R158G, T478K, D950N"}},"children":[{"name":"NODE_0000522","node_attrs":{"div":29,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.1252341270446777}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","C5184T","G9203A","T9678C","C11005A","A17496G","A20396G","A21792C","C28253T"],"ORF1a":["P309L","P1640L","D2980N","F3138S","H3580Q"],"ORF1b":["K2310R"],"S":["K77T"]},"labels":{"aa":"ORF1a: P309L, P1640L, D2980N, F3138S, H3580Q; ORF1b: K2310R; S: K77T","spike_mutations":"K77T"}},"children":[{"name":"AY.35","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.35"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.42242431640625}},"branch_attrs":{"mutations":{"nuc":["A1C","C6027A","C13989T","C16915T","G23012C"],"ORF1a":["P1921Q"],"S":["E484Q"]},"labels":{"aa":"ORF1a: P1921Q; S: E484Q","spike_mutations":"E484Q"}}},{"name":"AY.48","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.48"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A10399G","C10868T","G27948T"],"ORF8":["E19*"]},"labels":{"aa":"ORF8: E19*"}}}]},{"name":"NODE_0000523","node_attrs":{"div":21,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.307433843612671}},"branch_attrs":{"mutations":{"nuc":["G15451A","C16466T"],"ORF1b":["G662S","P1000L"]},"labels":{"aa":"ORF1b: G662S, P1000L"}},"children":[{"name":"B.1.617.2","node_attrs":{"div":21,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.307433843612671}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000524","node_attrs":{"div":24,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.925917625427246}},"branch_attrs":{"mutations":{"nuc":["C5184T","C9891T","T11418C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-"],"ORF1a":["P1640L","A3209V","V3718A"],"ORF8":["D119-","F120-"]},"labels":{"aa":"ORF1a: P1640L, A3209V, V3718A; ORF8: D119-, F120-"}},"children":[{"name":"NODE_0000525","node_attrs":{"div":29,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.995262622833252}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","T12946C","A20262G","C27739T"],"ORF1a":["P309L"],"ORF7a":["L116F"]},"labels":{"aa":"ORF1a: P309L; ORF7a: L116F"}},"children":[{"name":"NODE_0000526","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.093592643737793}},"branch_attrs":{"mutations":{"nuc":["C6539T","C20320T","C24745T","G28690T","G29427A"],"N":["L139F","R385K"],"ORF1a":["H2092Y"],"ORF1b":["H2285Y"]},"labels":{"aa":"N: L139F, R385K; ORF1a: H2092Y; ORF1b: H2285Y"}},"children":[{"name":"AY.30","node_attrs":{"div":37,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.30"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-02"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.6562891006469727}},"branch_attrs":{"mutations":{"nuc":["C9319T","A13482G","-28271A","G29781T"]}}},{"name":"AY.40","node_attrs":{"div":41,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.40"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["A1558G","C1912T","G2755T","A15892G","G23282T","C28099T","T28297C"],"ORF1a":["I431M"],"ORF1b":["M809V"],"ORF8":["S69L"],"ORF9b":["I5T"],"S":["D574Y"]},"labels":{"aa":"ORF1a: I431M; ORF1b: M809V; ORF8: S69L; ORF9b: I5T; S: D574Y","spike_mutations":"D574Y"}}}]},{"name":"NODE_0000527","node_attrs":{"div":30,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.395604133605957}},"branch_attrs":{"mutations":{"nuc":["C18176T"],"ORF1b":["P1570L"]},"labels":{"aa":"ORF1b: P1570L"}},"children":[{"name":"AY.49","node_attrs":{"div":36,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"21A"},"qc.frameShifts.frameShifts":{"value":"ORF3a:30-276"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF3a:30-276"},"partiallyAliased":{"value":"B.1.617.2.49"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T5773C","C10834T","C23039G","G24124T","G25471-","A25472-","T25473-","T25474-","T25475-","T25476-","G25477-","T25478-","C26110T","A27979T"],"ORF3a":["L26-","D27-","F28-","V29-"],"ORF8":["Q29L"],"S":["Q493E","K854N"]},"labels":{"aa":"ORF3a: L26-, D27-, F28-, V29-; ORF8: Q29L; S: Q493E, K854N","spike_mutations":"Q493E, K854N"}}},{"name":"AY.50","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.50"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C884T","C5730T","C19554T","G22484C","-28271A","G28809T"],"N":["G179V"],"ORF1a":["R207C","T1822I"],"S":["V308L"]},"labels":{"aa":"N: G179V; ORF1a: R207C, T1822I; S: V308L","spike_mutations":"V308L"}}},{"name":"AY.52","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.52"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["T24984G","T25689C","G26428T","C26858T","C28419T"],"E":["V62F"],"N":["T49I"],"S":["L1141W"]},"labels":{"aa":"E: V62F; N: T49I; S: L1141W","spike_mutations":"L1141W"}}},{"name":"AY.53","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.53"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.5879409313201904}},"branch_attrs":{"mutations":{"nuc":["G1738T","A2292C","C18348T","C20031T","G21641T"],"ORF1a":["Q676P"],"S":["A27S"]},"labels":{"aa":"ORF1a: Q676P; S: A27S","spike_mutations":"A27S"}}},{"name":"AY.8","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.8"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.8487331867218018}},"branch_attrs":{"mutations":{"nuc":["C11455T","A14170G"],"ORF1b":["I235V"]},"labels":{"aa":"ORF1b: I235V"}}},{"name":"NODE_0000528","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.849754571914673}},"branch_attrs":{"mutations":{"nuc":["A18468G"]}},"children":[{"name":"AY.13","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.13"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.3170342445373535}},"branch_attrs":{"mutations":{"nuc":["A17406G","C29095T"]}}},{"name":"NODE_0000529","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{"nuc":["T26076A"]}},"children":[{"name":"AY.16","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.16"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{}}},{"name":"AY.16.1","node_attrs":{"div":37,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.16.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C8407T","A12417G","G12911A","C14913T","T29867A"],"ORF1a":["N4051S","V4216I"]},"labels":{"aa":"ORF1a: N4051S, V4216I"}}}]}]},{"name":"NODE_0000530","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.429879188537598}},"branch_attrs":{"mutations":{"nuc":["C19160T"],"ORF1b":["S1898F"]},"labels":{"aa":"ORF1b: S1898F"}},"children":[{"name":"AY.15","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.15"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.385550022125244}},"branch_attrs":{"mutations":{"nuc":["A16872G","G27382C","-28271A"],"ORF6":["D61H"]},"labels":{"aa":"ORF6: D61H"}}},{"name":"AY.14","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.14"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1877G","G20718T"],"ORF1a":["S538A"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1a: S538A; ORF1b: M2417I"}}},{"name":"AY.54","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.54"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.0774948596954346}},"branch_attrs":{"mutations":{"nuc":["A1G","C193T","G14187A","A25806G"]}}}]},{"name":"NODE_0000531","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.021132946014404}},"branch_attrs":{"mutations":{"nuc":["A25562G"],"ORF3a":["Q57R"]},"labels":{"aa":"ORF3a: Q57R"}},"children":[{"name":"AY.17","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.17"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2240G","C14708T","C17436T","-28271A"],"ORF1a":["I659V"],"ORF1b":["A414V"]},"labels":{"aa":"ORF1a: I659V; ORF1b: A414V"}}},{"name":"AY.19","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.19"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25019T","G25947T","-28271A"],"ORF3a":["Q185H"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: Q185H; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"AY.51","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.51"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.13735818862915}},"branch_attrs":{"mutations":{"nuc":["G12223T","A25697T"],"ORF3a":["E102V"]},"labels":{"aa":"ORF3a: E102V"}}}]}]}]},{"name":"NODE_0000532","node_attrs":{"div":26,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.616595983505249}},"branch_attrs":{"mutations":{"nuc":["C11514T","C22227T"],"ORF1a":["T3750I"],"S":["A222V"]},"labels":{"aa":"ORF1a: T3750I; S: A222V","clade":"21I","spike_mutations":"A222V"}},"children":[{"name":"AY.62","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.62"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["A1045T","G1820A","A20085G","C28093T","G29440A"],"ORF1a":["G519S"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: G519S; ORF8: S67F"}}},{"name":"NODE_0000533","node_attrs":{"div":27,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.667755365371704}},"branch_attrs":{"mutations":{"nuc":["A5584G"]}},"children":[{"name":"AY.24","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.24"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-17"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.5928659439086914}},"branch_attrs":{"mutations":{"nuc":["C23896T","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"NODE_0000534","node_attrs":{"div":28,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.900347948074341}},"branch_attrs":{"mutations":{"nuc":["C13019T"]}},"children":[{"name":"AY.10","node_attrs":{"div":34,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.10"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.07296895980835}},"branch_attrs":{"mutations":{"nuc":["G219T","A8651G","G9526T","C12756T","C13665T","A23734G"],"ORF1a":["M2796V","M3087I","T4164I"]},"labels":{"aa":"ORF1a: M2796V, M3087I, T4164I"}}},{"name":"AY.11","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.11"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-09"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.418825149536133}},"branch_attrs":{"mutations":{"nuc":["C3486T","C18526T","T19516C","G26526T","C29509T"],"M":["A2S"],"ORF1a":["A1074V"],"ORF1b":["R1687C"]},"labels":{"aa":"M: A2S; ORF1a: A1074V; ORF1b: R1687C"}}},{"name":"AY.27","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.27"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.842771530151367}},"branch_attrs":{"mutations":{"nuc":["T11938C","A14475G","G29422T"]}}},{"name":"AY.28","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.28"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C335T","G2167T","C8950T","C9246T","G23663T","G24794T","G25855T"],"ORF1a":["R24C","K634N","A2994V"],"ORF3a":["D155Y"],"S":["A701S","A1078S"]},"labels":{"aa":"ORF1a: R24C, K634N, A2994V; ORF3a: D155Y; S: A701S, A1078S","spike_mutations":"A701S, A1078S"}}},{"name":"AY.47","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.47"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.620307207107544}},"branch_attrs":{"mutations":{"nuc":["C1684T","G5164T","C12049T","G22427A","G28326T"],"N":["G18V"],"ORF1a":["E1633D"],"ORF9b":["V15L"],"S":["V289I"]},"labels":{"aa":"N: G18V; ORF1a: E1633D; ORF9b: V15L; S: V289I","spike_mutations":"V289I"}}},{"name":"AY.55","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.55"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.71439266204834}},"branch_attrs":{"mutations":{"nuc":["A10978G","-28271A"]}}},{"name":"AY.56","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.56"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3634T","C25624T","G27870T"],"ORF3a":["H78Y"],"ORF7b":["E39*"]},"labels":{"aa":"ORF3a: H78Y; ORF7b: E39*"}}},{"name":"AY.57","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.57"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.764986515045166}},"branch_attrs":{"mutations":{"nuc":["C1403T","G5584T"],"ORF1a":["P380S"]},"labels":{"aa":"ORF1a: P380S"}}},{"name":"AY.59","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.59"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C19164T","T20391G","C21302T"],"ORF1b":["P2612L"]},"labels":{"aa":"ORF1b: P2612L"}}},{"name":"AY.60","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.60"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A2165C","C2919T","G4162T","T8634C","T12056A","T13701C","G17122T"],"ORF1a":["K634Q","P885L","I2790T","C3931S"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1a: K634Q, P885L, I2790T, C3931S; ORF1b: A1219S"}}},{"name":"AY.61","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.61"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9422552585601807}},"branch_attrs":{"mutations":{"nuc":["T25532C"],"ORF3a":["I47T"]},"labels":{"aa":"ORF3a: I47T"}}},{"name":"AY.64","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.64"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9437766075134277}},"branch_attrs":{"mutations":{"nuc":["T2C","C346T","C5784T","C6388T","C24130T","G25135T","G25691T","C27005T","G29254T","G29688T"],"ORF1a":["T1840I"],"ORF3a":["G100V"],"S":["K1191N"]},"labels":{"aa":"ORF1a: T1840I; ORF3a: G100V; S: K1191N","spike_mutations":"K1191N"}}},{"name":"AY.67","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.67"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C4890T","T5644C","T19519C","A27368G"],"ORF1a":["T1542I"],"ORF1b":["Y2018H"],"ORF6":["Q56R"]},"labels":{"aa":"ORF1a: T1542I; ORF1b: Y2018H; ORF6: Q56R"}}},{"name":"AY.68","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.68"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.760132312774658}},"branch_attrs":{"mutations":{"nuc":["G105T","C3294T","C8208T","C14362T","C19524T","A22320C","T24499A","C25782T","A26891G","T27878C"],"ORF1a":["P1010L","T2648I"],"S":["D253A","D979E"]},"labels":{"aa":"ORF1a: P1010L, T2648I; S: D253A, D979E","spike_mutations":"D253A, D979E"}}},{"name":"AY.66","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.66"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T13C","T6496C","G14874T","C28892T"],"N":["P207S"],"ORF1b":["K469N"]},"labels":{"aa":"N: P207S; ORF1b: K469N"}}},{"name":"AY.69","node_attrs":{"div":36,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.69"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C3984T","A4405T","A4838G","G9431A","G16864A","G17847A","G25720T","C27559T"],"ORF1a":["T1240I","I1525V","V3056I"],"ORF1b":["V1133I"],"ORF3a":["A110S"]},"labels":{"aa":"ORF1a: T1240I, I1525V, V3056I; ORF1b: V1133I; ORF3a: A110S"}}},{"name":"AY.70","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.70"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.4444899559020996}},"branch_attrs":{"mutations":{"nuc":["C4891T","G21255T","G21624C","G28899T","G28903T"],"N":["R209I","M210I"],"S":["R21T"]},"labels":{"aa":"N: R209I, M210I; S: R21T","spike_mutations":"R21T"}}},{"name":"NODE_0000535","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.80359411239624}},"branch_attrs":{"mutations":{"nuc":["C5192T"]}},"children":[{"name":"AY.58","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.58"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["G8540A","C26079A","C27131T"],"ORF1a":["A2759T"]},"labels":{"aa":"ORF1a: A2759T"}}},{"name":"AY.63","node_attrs":{"div":39,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.63"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.740610122680664}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","A7886G","C8964T","C9857T","C13335T","A14246G","A19126G","A23848G","C25710T","G29616T","T29728C"],"ORF1a":["K141-","S142-","F143-","I2541V","S2900L","A4357V"],"ORF1b":["D260G","I1887V"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I2541V, S2900L, A4357V; ORF1b: D260G, I1887V"}}}]},{"name":"NODE_0000536","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1813859939575195}},"branch_attrs":{"mutations":{"nuc":["C21622T"]}},"children":[{"name":"AY.75","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1813859939575195}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000537","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.644587278366089}},"branch_attrs":{"mutations":{"nuc":["G29744A"]}},"children":[{"name":"AY.75.2","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-19"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T13C","T7717C","A16824G","A21987G","G23611T"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}}},{"name":"AY.75.3","node_attrs":{"div":36,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-19"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T322C","C1329A","G8428A","G16873A","T19127C","C22314T"],"ORF1a":["T355N"],"ORF1b":["G1136S","I1887T"],"S":["P251L"]},"labels":{"aa":"ORF1a: T355N; ORF1b: G1136S, I1887T; S: P251L","spike_mutations":"P251L"}}}]}]},{"name":"NODE_0000538","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.335732936859131}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"AY.9","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.335732936859131}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000539","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.805464744567871}},"branch_attrs":{"mutations":{"nuc":["G1729A","G14030A","C18086T"],"ORF1b":["R188Q","T1540I"]},"labels":{"aa":"ORF1b: R188Q, T1540I"}},"children":[{"name":"AY.9.2","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.805464744567871}},"branch_attrs":{"mutations":{}}},{"name":"AY.9.2.2","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6840121746063232}},"branch_attrs":{"mutations":{"nuc":["C4321T","A9685G","C23585A"],"ORF1a":["I3140M"],"S":["Q675K"]},"labels":{"aa":"ORF1a: I3140M; S: Q675K","spike_mutations":"Q675K"}}}]}]},{"name":"NODE_0000540","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.977773427963257}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.133","node_attrs":{"div":40,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.133"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.133"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-01"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C203T","C449T","C4763T","C12025T","C20104T","T21613A","C21614T","C23058G","C24370T","T25333C","T29867A"],"ORF1a":["P62S","H1500Y"],"ORF1b":["L2213F"],"S":["N17K","L18F","P499R"]},"labels":{"aa":"ORF1a: P62S, H1500Y; ORF1b: L2213F; S: N17K, L18F, P499R","spike_mutations":"N17K, L18F, P499R"}}},{"name":"NODE_0000541","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T13019C"]}},"children":[{"name":"AY.65","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:121-122"},"partiallyAliased":{"value":"B.1.617.2.65"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G14028T","C27005T","-28253T","-28271A"],"ORF1b":["M187I"]},"labels":{"aa":"ORF1b: M187I"}}},{"name":"NODE_0000542","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.0165014266967773}},"branch_attrs":{"mutations":{"nuc":["A27345T"],"ORF6":["K48N"]},"labels":{"aa":"ORF6: K48N"}},"children":[{"name":"AY.26","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.26"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.0165014266967773}},"branch_attrs":{"mutations":{}}},{"name":"AY.26.1","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.26.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G20580T","A21987G","G23012C","A24587T","G26529C","G27703T","C29769T"],"M":["D3H"],"ORF7a":["V104F"],"S":["D142G","E484Q","T1009S"]},"labels":{"aa":"M: D3H; ORF7a: V104F; S: D142G, E484Q, T1009S","spike_mutations":"D142G, E484Q, T1009S"}}}]}]}]},{"name":"NODE_0000543","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.119155406951904}},"branch_attrs":{"mutations":{"nuc":["C2509T"]}},"children":[{"name":"AY.2","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-14"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6743454933166504}},"branch_attrs":{"mutations":{"nuc":["A1G","T3055C","G3701A","C17336T","C18570T","G21770T","G22813T","T29867A","G29868A"],"ORF1a":["A1146T"],"ORF1b":["T1290I"],"S":["V70F","K417N"]},"labels":{"aa":"ORF1a: A1146T; ORF1b: T1290I; S: V70F, K417N","spike_mutations":"V70F, K417N"}}},{"name":"AY.38","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.38"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.963697910308838}},"branch_attrs":{"mutations":{"nuc":["G15760T","A22310T","-28271A","G29212T","T29742G"],"ORF1b":["G765C"],"S":["T250S"]},"labels":{"aa":"ORF1b: G765C; S: T250S","spike_mutations":"T250S"}}},{"name":"AY.37","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.37"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6478559970855713}},"branch_attrs":{"mutations":{"nuc":["G2185T","T20911C"],"ORF1a":["E640D"]},"labels":{"aa":"ORF1a: E640D"}}},{"name":"AY.71","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.71"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.8321352005004883}},"branch_attrs":{"mutations":{"nuc":["A1T","C25317T","-28271A"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"NODE_0000544","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.954825401306152}},"branch_attrs":{"mutations":{"nuc":["G5539A"]}},"children":[{"name":"AY.72","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.72"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.11883020401001}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G6080T","A25856G","C26013T"],"ORF1a":["K141-","S142-","F143-","D1939Y"],"ORF3a":["D155G"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, D1939Y; ORF3a: D155G"}}},{"name":"AY.74","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.74"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1409428119659424}},"branch_attrs":{"mutations":{"nuc":["G3994A","C25413T","G29392T"],"N":["K373N"]},"labels":{"aa":"N: K373N"}}},{"name":"AY.73","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.73"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9488861560821533}},"branch_attrs":{"mutations":{"nuc":["C222T","C6573T","C27657T","C28409T","C28893T"],"N":["P46S","P207L"],"ORF1a":["S2103F"]},"labels":{"aa":"N: P46S, P207L; ORF1a: S2103F"}}}]}]}]}]}]}]},{"name":"NODE_0000545","node_attrs":{"div":31,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1954586505889893}},"branch_attrs":{"mutations":{"nuc":["G4181T","C6402T","C7124T","C8986T","C10029T","A11201G","A11332G","C19220T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","G28916T"],"N":["G215C"],"ORF1a":["A1306S","P2046L","P2287S","T3255I","T3646A"],"ORF1b":["A1918V"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"]},"labels":{"aa":"N: G215C; ORF1a: A1306S, P2046L, P2287S, T3255I, T3646A; ORF1b: A1918V; ORF7b: T40I; ORF8: D119-, F120-","clade":"21J"}},"children":[{"name":"AY.78","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.78"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.552375793457031}},"branch_attrs":{"mutations":{"nuc":["T13188C","G14874T","G15372T","C21846T","-28271A","C29200T","G29227A"],"ORF1a":["I4308T"],"ORF1b":["K469N"],"S":["T95I"]},"labels":{"aa":"ORF1a: I4308T; ORF1b: K469N; S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000546","node_attrs":{"div":32,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.353039264678955}},"branch_attrs":{"mutations":{"nuc":["G9053T"],"ORF1a":["V2930L"]},"labels":{"aa":"ORF1a: V2930L"}},"children":[{"name":"AY.109","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.109"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.109"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6555240154266357}},"branch_attrs":{"mutations":{"nuc":["A11595G","A14836G","C27549T"],"ORF1a":["Q3777R"],"ORF1b":["I457V"]},"labels":{"aa":"ORF1a: Q3777R; ORF1b: I457V"}}},{"name":"AY.44","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.44"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.8053845167160034}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14014G","A29700G"],"ORF1b":["F183V"]},"labels":{"aa":"ORF1b: F183V"}}},{"name":"AY.6","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.7393529415130615}},"branch_attrs":{"mutations":{"nuc":["G2336A","G17331T"],"ORF1a":["D691N"],"ORF1b":["E1288D"]},"labels":{"aa":"ORF1a: D691N; ORF1b: E1288D"}}},{"name":"AY.76","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.76"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.615240097045898}},"branch_attrs":{"mutations":{"nuc":["T7233C","A16775G"],"ORF1a":["L2323S"],"ORF1b":["Y1103C"]},"labels":{"aa":"ORF1a: L2323S; ORF1b: Y1103C"}}},{"name":"AY.77","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:120-122"},"partiallyAliased":{"value":"B.1.617.2.77"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.287630558013916}},"branch_attrs":{"mutations":{"nuc":["C10376T","T27346C","-28250T","-28251T","-28252T","-28253C"],"ORF1a":["P3371S"],"ORF6":["Y49H"]},"labels":{"aa":"ORF1a: P3371S; ORF6: Y49H"}}},{"name":"AY.79","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.79"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7262611389160156}},"branch_attrs":{"mutations":{"nuc":["T2125C"]}}},{"name":"AY.80","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.80"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.398505210876465}},"branch_attrs":{"mutations":{"nuc":["G5017A","G12479A","C19186T","G19735T","G28028T"],"ORF1a":["V4072I"],"ORF1b":["D2090Y"],"ORF8":["W45C"]},"labels":{"aa":"ORF1a: V4072I; ORF1b: D2090Y; ORF8: W45C"}}},{"name":"AY.81","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.81"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.495386123657227}},"branch_attrs":{"mutations":{"nuc":["G11358A","C23643T","G25340T","A28032G","C28087T","C29530T"],"ORF1a":["R3698K"],"ORF8":["I47V","A65V"],"S":["A694V","D1260Y"]},"labels":{"aa":"ORF1a: R3698K; ORF8: I47V, A65V; S: A694V, D1260Y","spike_mutations":"A694V, D1260Y"}}},{"name":"AY.82","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.82"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.4367475509643555}},"branch_attrs":{"mutations":{"nuc":["C9144T","C22783T"],"ORF1a":["S2960F"]},"labels":{"aa":"ORF1a: S2960F"}}},{"name":"AY.83","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.83"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.207631587982178}},"branch_attrs":{"mutations":{"nuc":["C5544T","G15243T","A25491T"],"ORF1a":["T1760I"],"ORF1b":["M592I"]},"labels":{"aa":"ORF1a: T1760I; ORF1b: M592I"}}},{"name":"AY.84","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.84"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.84"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.880310297012329}},"branch_attrs":{"mutations":{"nuc":["C27297T","G28086T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"AY.86","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.86"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.149416446685791}},"branch_attrs":{"mutations":{"nuc":["G15380T","G24095T","C29445T"],"N":["T391I"],"ORF1b":["S638I"],"S":["A845S"]},"labels":{"aa":"N: T391I; ORF1b: S638I; S: A845S","spike_mutations":"A845S"}}},{"name":"AY.87","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.87"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.119330883026123}},"branch_attrs":{"mutations":{"nuc":["C832T","C2091T","C12651T","C17156T","A19815T","G27556T"],"ORF1a":["T609I","T4129I"],"ORF1b":["T1230I"],"ORF7a":["A55S"]},"labels":{"aa":"ORF1a: T609I, T4129I; ORF1b: T1230I; ORF7a: A55S"}}},{"name":"AY.88","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.88"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.88"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.2233734130859375}},"branch_attrs":{"mutations":{"nuc":["G20709T","C28724T"],"N":["P151S"],"ORF1b":["M2414I"]},"labels":{"aa":"N: P151S; ORF1b: M2414I"}}},{"name":"AY.93","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.93"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.93"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.618436336517334}},"branch_attrs":{"mutations":{"nuc":["A1087G","C1101T","C7262T"],"ORF1a":["S279F","L2333F"]},"labels":{"aa":"ORF1a: S279F, L2333F"}}},{"name":"AY.94","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.94"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.94"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7355687618255615}},"branch_attrs":{"mutations":{"nuc":["G463A","G6367T","C15924T","G16975T","C22987T"],"ORF1a":["Q2034H"],"ORF1b":["V1170F"]},"labels":{"aa":"ORF1a: Q2034H; ORF1b: V1170F"}}},{"name":"NODE_0000547","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.328933000564575}},"branch_attrs":{"mutations":{"nuc":["A17236G"],"ORF1b":["I1257V"]},"labels":{"aa":"ORF1b: I1257V"}},"children":[{"name":"AY.103","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.103"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.103"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7267297506332397}},"branch_attrs":{"mutations":{"nuc":["C24208T"]}}},{"name":"AY.41","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.41"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3743410110473633}},"branch_attrs":{"mutations":{"nuc":["G1820A","G2272T","G7936T","G9220A","A13712G","C14119T","C18395T","G22346T","G22992T","G25062T","-28271A"],"ORF1a":["G519S","K669N"],"ORF1b":["K82R","P218S","A1643V"],"S":["A262S","S477I","G1167V"]},"labels":{"aa":"ORF1a: G519S, K669N; ORF1b: K82R, P218S, A1643V; S: A262S, S477I, G1167V","spike_mutations":"A262S, S477I, G1167V"}}}]},{"name":"NODE_0000548","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.456480503082275}},"branch_attrs":{"mutations":{"nuc":["C897T","C5730T","A7519C","C15738T","G17790T","C25350T","G27762T"],"ORF1a":["A211V","T1822I"],"ORF1b":["Q1441H"],"ORF7b":["E3*"],"S":["P1263L"]},"labels":{"aa":"ORF1a: A211V, T1822I; ORF1b: Q1441H; ORF7b: E3*; S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"AY.123","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.123"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-23"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.456480503082275}},"branch_attrs":{"mutations":{}}},{"name":"AY.123.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.123.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.658047676086426}},"branch_attrs":{"mutations":{"nuc":["G20002T","A24410G"],"ORF1b":["D2179Y"],"S":["N950D"]},"labels":{"aa":"ORF1b: D2179Y; S: N950D","spike_mutations":"N950D"}}}]},{"name":"NODE_0000549","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.341156005859375}},"branch_attrs":{"mutations":{"nuc":["C1404T","C4752T","G25352T"],"ORF1a":["P380L","T1496I"],"S":["V1264L"]},"labels":{"aa":"ORF1a: P380L, T1496I; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.23","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.23"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.341156005859375}},"branch_attrs":{"mutations":{}}},{"name":"AY.23.1","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.23.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4683516025543213}},"branch_attrs":{"mutations":{"nuc":["C1263T","C5497T","A7537G","C12100T","A14748G","G17679T","T22213C","C25262A"],"ORF1a":["T333M"],"S":["L1234I"]},"labels":{"aa":"ORF1a: T333M; S: L1234I","spike_mutations":"L1234I"}}}]},{"name":"NODE_0000550","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.604698181152344}},"branch_attrs":{"mutations":{"nuc":["C23277T","G24124A","-28271A"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"AY.32","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.32"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-03"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.967384099960327}},"branch_attrs":{"mutations":{"nuc":["C9286T","C21304T"],"ORF1b":["R2613C"]},"labels":{"aa":"ORF1b: R2613C"}}},{"name":"AY.95","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.95"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.95"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.071098804473877}},"branch_attrs":{"mutations":{"nuc":["T22293C"],"S":["L244S"]},"labels":{"aa":"S: L244S","spike_mutations":"L244S"}}}]},{"name":"NODE_0000551","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.153012275695801}},"branch_attrs":{"mutations":{"nuc":["A21647G","C22311T"],"S":["T29A","T250I"]},"labels":{"aa":"S: T29A, T250I","spike_mutations":"T29A, T250I"}},"children":[{"name":"AY.33.1","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:77-122"},"partiallyAliased":{"value":"B.1.617.2.33.1"},"totalAminoacidDeletions":{"value":26},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C4182T","T10190C","A11111G","C14318T","C17439T","A18887G","G21010T","C21707T","C22458T","G23401T","G23522A","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-"],"ORF1a":["S1306F","S3309P","M3616V"],"ORF1b":["T284I","H1807R","V2515L"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-"],"S":["H49Y","T299I","Q613H","E654K"]},"labels":{"aa":"ORF1a: S1306F, S3309P, M3616V; ORF1b: T284I, H1807R, V2515L; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-; S: H49Y, T299I, Q613H, E654K","spike_mutations":"H49Y, T299I, Q613H, E654K"}}},{"name":"AY.33","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.33"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.153012275695801}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000552","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.514620304107666}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"AY.46.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.053738117218018}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T","G14186T","C19637T","A21987G","G28378T"],"ORF1a":["A3571V"],"ORF1b":["R240M","A2057V"],"ORF9b":["R32L"],"S":["D142G"]},"labels":{"aa":"ORF1a: A3571V; ORF1b: R240M, A2057V; ORF9b: R32L; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.90","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.90"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.90"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9251A","C25931T","G26720A","G27990T","T28735C"],"ORF1a":["V2996I"],"ORF3a":["S180F"],"ORF8":["V33F"]},"labels":{"aa":"ORF1a: V2996I; ORF3a: S180F; ORF8: V33F"}}}]},{"name":"NODE_0000553","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.887284278869629}},"branch_attrs":{"mutations":{"nuc":["G526T","C19524T"],"ORF1a":["E87D"]},"labels":{"aa":"ORF1a: E87D"}},"children":[{"name":"AY.98","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.98"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.887284278869629}},"branch_attrs":{"mutations":{}}},{"name":"AY.98.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.98.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.6238064765930176}},"branch_attrs":{"mutations":{"nuc":["G2518T","G5437T","C7768T","C22314T","G28086T"],"ORF1a":["E1724D"],"ORF8":["A65S"],"S":["P251L"]},"labels":{"aa":"ORF1a: E1724D; ORF8: A65S; S: P251L","spike_mutations":"P251L"}}}]},{"name":"NODE_0000554","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.317579746246338}},"branch_attrs":{"mutations":{"nuc":["A1G","G26107C","A27507C"],"ORF3a":["E239Q"]},"labels":{"aa":"ORF3a: E239Q"}},"children":[{"name":"AY.25","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.317579746246338}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000555","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432563543319702}},"branch_attrs":{"mutations":{"nuc":["A3948G","G11562T"],"ORF1a":["D1228G","C3766F"]},"labels":{"aa":"ORF1a: D1228G, C3766F"}},"children":[{"name":"AY.25.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432563543319702}},"branch_attrs":{"mutations":{}}},{"name":"AY.25.1.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2407732009887695}},"branch_attrs":{"mutations":{"nuc":["G2564A","A21987G","G23948T"],"ORF1a":["E767K"],"S":["D142G","D796Y"]},"labels":{"aa":"ORF1a: E767K; S: D142G, D796Y","spike_mutations":"D142G, D796Y"}}}]}]},{"name":"NODE_0000556","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.293525695800781}},"branch_attrs":{"mutations":{"nuc":["C25413T","-28271A"]}},"children":[{"name":"AY.45","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.45"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.303795337677002}},"branch_attrs":{"mutations":{"nuc":["G13812T"],"ORF1b":["M115I"]},"labels":{"aa":"ORF1b: M115I"}}},{"name":"NODE_0000557","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.198975563049316}},"branch_attrs":{"mutations":{"nuc":["T1871C","C28236T","G29744A"],"ORF1a":["F536L"],"ORF8":["R115C"]},"labels":{"aa":"ORF1a: F536L; ORF8: R115C"}},"children":[{"name":"AY.91.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.91.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.92111349105835}},"branch_attrs":{"mutations":{"nuc":["C15540T","C17010T","G25650T","A28271-","C28310T"],"N":["P13S"],"ORF3a":["L86F"]},"labels":{"aa":"N: P13S; ORF3a: L86F"}}},{"name":"AY.91","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.91"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.198975563049316}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000558","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.897754669189453}},"branch_attrs":{"mutations":{"nuc":["T2C","G2944A","G11365T","G12718T","G27566T","C27629A"],"ORF1a":["Q4151H"],"ORF7a":["C58F","A79D"]},"labels":{"aa":"ORF1a: Q4151H; ORF7a: C58F, A79D"}},"children":[{"name":"AY.7","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.897754669189453}},"branch_attrs":{"mutations":{}}},{"name":"AY.7.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-13"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1598992347717285}},"branch_attrs":{"mutations":{"nuc":["T15882G","A18675G"]}}},{"name":"AY.7.2","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-13"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.763446092605591}},"branch_attrs":{"mutations":{"nuc":["C2T","G25445T"],"ORF3a":["G18V"]},"labels":{"aa":"ORF3a: G18V"}}}]},{"name":"NODE_0000559","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5587968826293945}},"branch_attrs":{"mutations":{"nuc":["A3536G","T13216C","C15240T"],"ORF1a":["I1091V"]},"labels":{"aa":"ORF1a: I1091V"}},"children":[{"name":"AY.99","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5587968826293945}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000560","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.528911113739014}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.99.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.143618583679199}},"branch_attrs":{"mutations":{"nuc":["C8994T"],"ORF1a":["T2910I"]},"labels":{"aa":"ORF1a: T2910I"}}},{"name":"AY.99.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.7914319038391113}},"branch_attrs":{"mutations":{"nuc":["C4927T","A5638G","C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}}]}]},{"name":"NODE_0000561","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.159926652908325}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"AY.122","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.159926652908325}},"branch_attrs":{"mutations":{}}},{"name":"AY.122.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5672764778137207}},"branch_attrs":{"mutations":{"nuc":["C19983T","G20937T","C23934T","C25516T"],"ORF3a":["P42S"],"S":["T791I"]},"labels":{"aa":"ORF3a: P42S; S: T791I","spike_mutations":"T791I"}}},{"name":"AY.122.3","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.337822437286377}},"branch_attrs":{"mutations":{"nuc":["T168C","C12513T","G17338A","T17694C","T20838C","G23401T","C27527T","C28873A"],"ORF1a":["T4083M"],"ORF1b":["A1291T"],"ORF7a":["P45L"],"S":["Q613H"]},"labels":{"aa":"ORF1a: T4083M; ORF1b: A1291T; ORF7a: P45L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"AY.122.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7381060123443604}},"branch_attrs":{"mutations":{"nuc":["G13892A","G14772A","G22793T"],"ORF1b":["C142Y"],"S":["A411S"]},"labels":{"aa":"ORF1b: C142Y; S: A411S","spike_mutations":"A411S"}}}]},{"name":"NODE_0000562","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.67804217338562}},"branch_attrs":{"mutations":{"nuc":["T3C","A11456G","G29050A","C29509T"],"ORF1a":["I3731V"]},"labels":{"aa":"ORF1a: I3731V"}},"children":[{"name":"AY.3","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-30"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.67804217338562}},"branch_attrs":{"mutations":{}}},{"name":"AY.3.2","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.84430193901062}},"branch_attrs":{"mutations":{"nuc":["G5155A","C5784T","A10075G","A21987G","C22338T","C29546T","C29750T"],"ORF1a":["T1840I"],"S":["D142G","T259I"]},"labels":{"aa":"ORF1a: T1840I; S: D142G, T259I","spike_mutations":"D142G, T259I"}}},{"name":"NODE_0000563","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.2109897136688232}},"branch_attrs":{"mutations":{"nuc":["T23284C","C25339T"]}},"children":[{"name":"AY.3.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-23"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9937832355499268}},"branch_attrs":{"mutations":{"nuc":["G3644T","C18115T","C20199T","A21987G"],"ORF1a":["D1127Y"],"ORF1b":["H1550Y"],"S":["D142G"]},"labels":{"aa":"ORF1a: D1127Y; ORF1b: H1550Y; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.3.3","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.715099811553955}},"branch_attrs":{"mutations":{"nuc":["T2083C","A6229G","C9924T","T12538C","G21770A","A22803G","A26021C"],"ORF1a":["A3220V"],"ORF3a":["D210A"],"S":["V70I","Q414R"]},"labels":{"aa":"ORF1a: A3220V; ORF3a: D210A; S: V70I, Q414R","spike_mutations":"V70I, Q414R"}}}]}]},{"name":"NODE_0000564","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3763246536254883}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T"],"ORF1a":["A3571V"]},"labels":{"aa":"ORF1a: A3571V"}},"children":[{"name":"AY.46.2","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9185075759887695}},"branch_attrs":{"mutations":{"nuc":["A17799G","-28271A"]}}},{"name":"AY.46","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3763246536254883}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.46.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.001236915588379}},"branch_attrs":{"mutations":{"nuc":["T25673C"],"ORF3a":["L94P"]},"labels":{"aa":"ORF3a: L94P"}}},{"name":"AY.46.6","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.815885066986084}},"branch_attrs":{"mutations":{"nuc":["C6310T","C8326T"]}}},{"name":"AY.46.5","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0684127807617188}},"branch_attrs":{"mutations":{"nuc":["C15569T","T16242G"],"ORF1b":["T701I"]},"labels":{"aa":"ORF1b: T701I"}}},{"name":"AY.46.4","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.352943181991577}},"branch_attrs":{"mutations":{"nuc":["G23545T"],"S":["E661D"]},"labels":{"aa":"S: E661D","spike_mutations":"E661D"}}}]},{"name":"NODE_0000565","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6843671798706055}},"branch_attrs":{"mutations":{"nuc":["G24928T"]}},"children":[{"name":"AY.5","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6843671798706055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000566","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432929515838623}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}},"children":[{"name":"AY.5.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.634615898132324}},"branch_attrs":{"mutations":{"nuc":["C27143A"],"M":["N207K"]},"labels":{"aa":"M: N207K"}}},{"name":"AY.5.3","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.852130651473999}},"branch_attrs":{"mutations":{"nuc":["C7488T"],"ORF1a":["T2408I"]},"labels":{"aa":"ORF1a: T2408I"}}},{"name":"AY.5.4","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5176773071289062}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"AY.5.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.416350364685059}},"branch_attrs":{"mutations":{"nuc":["C12369T","C25572T"],"ORF1a":["T4035I"]},"labels":{"aa":"ORF1a: T4035I"}}},{"name":"AY.5.5","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C6840T","G17193T","T23398C"],"ORF1a":["A2192V"],"ORF1b":["E1242D"]},"labels":{"aa":"ORF1a: A2192V; ORF1b: E1242D"}}}]}]},{"name":"NODE_0000567","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.3014614582061768}},"branch_attrs":{"mutations":{"nuc":["C15952A","A28299T"],"N":["Q9L"],"ORF1b":["L829I"],"ORF9b":["S6C"]},"labels":{"aa":"N: Q9L; ORF1b: L829I; ORF9b: S6C"}},"children":[{"name":"AY.43","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.3014614582061768}},"branch_attrs":{"mutations":{}}},{"name":"AY.43.5","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["A17457G","A23064G","C23638T","C24937T","C28045T","G28857T","G29179T"],"N":["R195I"],"ORF8":["A51V"],"S":["N501S"]},"labels":{"aa":"N: R195I; ORF8: A51V; S: N501S","spike_mutations":"N501S"}}},{"name":"NODE_0000568","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.2774245738983154}},"branch_attrs":{"mutations":{"nuc":["C18744T","C24130T"]}},"children":[{"name":"AY.43.3","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.8283350467681885}},"branch_attrs":{"mutations":{"nuc":["C19955T"],"ORF1b":["T2163I"]},"labels":{"aa":"ORF1b: T2163I"}}},{"name":"AY.43.4","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.776319980621338}},"branch_attrs":{"mutations":{"nuc":["C5241T"],"ORF1a":["P1659L"]},"labels":{"aa":"ORF1a: P1659L"}}},{"name":"AY.43.6","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3442535400390625}},"branch_attrs":{"mutations":{"nuc":["C233T","C1952A","T27409C","G29081T"],"N":["V270L"],"ORF1a":["Q563K"],"ORF7a":["F6L"]},"labels":{"aa":"N: V270L; ORF1a: Q563K; ORF7a: F6L"}}},{"name":"NODE_0000569","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.388669013977051}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.43.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.167776584625244}},"branch_attrs":{"mutations":{"nuc":["C12663T","C25433T"],"ORF1a":["A4133V"],"ORF3a":["T14I"]},"labels":{"aa":"ORF1a: A4133V; ORF3a: T14I"}}},{"name":"AY.43.2","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.031640529632568}},"branch_attrs":{"mutations":{"nuc":["G3728T"],"ORF1a":["G1155C"]},"labels":{"aa":"ORF1a: G1155C"}}},{"name":"AY.43.7","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-26"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.195249557495117}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}}}]}]}]},{"name":"NODE_0000570","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.174302339553833}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}},"children":[{"name":"AY.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-04"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.566736936569214}},"branch_attrs":{"mutations":{"nuc":["G22335T","G22813T"],"S":["W258L","K417N"]},"labels":{"aa":"S: W258L, K417N","spike_mutations":"W258L, K417N"}}},{"name":"AY.105","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.105"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.105"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.090245246887207}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2939T"],"ORF1a":["P892S"]},"labels":{"aa":"ORF1a: P892S"}}},{"name":"AY.107","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.107"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.107"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.489321231842041}},"branch_attrs":{"mutations":{"nuc":["A15012G","C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"AY.106","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.106"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.106"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.667900800704956}},"branch_attrs":{"mutations":{"nuc":["C9811T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"AY.112","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.112"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.112"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2532191276550293}},"branch_attrs":{"mutations":{"nuc":["G25647T","-28271A"],"ORF3a":["L85F"]},"labels":{"aa":"ORF3a: L85F"}}},{"name":"AY.111","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.111"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.111"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2215194702148438}},"branch_attrs":{"mutations":{"nuc":["C4456T"]}}},{"name":"AY.110","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.110"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.110"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5870707035064697}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","C912A"],"ORF1a":["K141-","S142-","F143-","S216Y"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, S216Y"}}},{"name":"AY.117","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.117"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.117"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.009160041809082}},"branch_attrs":{"mutations":{"nuc":["A1G","G2202T","G14186T","C15810T","C28708T"],"ORF1a":["W646L"],"ORF1b":["R240M"]},"labels":{"aa":"ORF1a: W646L; ORF1b: R240M"}}},{"name":"AY.118","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.118"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.118"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-04"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.8734261989593506}},"branch_attrs":{"mutations":{"nuc":["A1C","T826C","A27338T"],"ORF6":["E46V"]},"labels":{"aa":"ORF6: E46V"}}},{"name":"AY.126","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.126"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.126"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.6275558471679688}},"branch_attrs":{"mutations":{"nuc":["A1T","C14925T","A21137G","A24110C","A25439C"],"ORF1b":["K2557R"],"ORF3a":["K16T"],"S":["I850L"]},"labels":{"aa":"ORF1b: K2557R; ORF3a: K16T; S: I850L","spike_mutations":"I850L"}}},{"name":"AY.129","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.129"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.129"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1022281646728516}},"branch_attrs":{"mutations":{"nuc":["A21194G","G28001T","T28156C"],"ORF1b":["D2576G"],"ORF8":["I88T"]},"labels":{"aa":"ORF1b: D2576G; ORF8: I88T"}}},{"name":"AY.131","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.131"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.131"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-21"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.790039539337158}},"branch_attrs":{"mutations":{"nuc":["C14407T","G19999T","G22899T","A23064C","T29014C","G29688T"],"ORF1b":["L314F","V2178F"],"S":["G446V","N501T"]},"labels":{"aa":"ORF1b: L314F, V2178F; S: G446V, N501T","spike_mutations":"G446V, N501T"}}},{"name":"AY.132","node_attrs":{"div":48,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.132"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.132"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-28"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.3016180992126465}},"branch_attrs":{"mutations":{"nuc":["G1418A","A2172G","C4754T","C7945T","G11161A","T11488C","G18213A","T19500C","A19908G","C23683T","C25710T","G25855T","C27131T","G27870T","C27881A"],"ORF1a":["A385T","K636R","P1497S"],"ORF1b":["M1582I","I2147M"],"ORF3a":["D155Y"],"ORF7b":["E39*","H42Q"]},"labels":{"aa":"ORF1a: A385T, K636R, P1497S; ORF1b: M1582I, I2147M; ORF3a: D155Y; ORF7b: E39*, H42Q"}}},{"name":"AY.92","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.92"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.92"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5235536098480225}},"branch_attrs":{"mutations":{"nuc":["C28657T","C29167T"]}}},{"name":"NODE_0000571","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9998865127563477}},"branch_attrs":{"mutations":{"nuc":["C745T"]}},"children":[{"name":"AY.104","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.104"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.104"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.191296577453613}},"branch_attrs":{"mutations":{"nuc":["T13048C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"AY.108","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.108"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.108"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.212674140930176}},"branch_attrs":{"mutations":{"nuc":["T2C","G370T","C823T","C6828T"],"ORF1a":["S2188F"]},"labels":{"aa":"ORF1a: S2188F"}}}]},{"name":"NODE_0000572","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9742491245269775}},"branch_attrs":{"mutations":{"nuc":["A10691G"],"ORF1a":["I3476V"]},"labels":{"aa":"ORF1a: I3476V"}},"children":[{"name":"AY.116","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.116"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9742491245269775}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.116.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.116.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5009799003601074}},"branch_attrs":{"mutations":{"nuc":["G12071A","C19160T","G20968A"],"ORF1a":["D3936N"],"ORF1b":["S1898F","V2501I"]},"labels":{"aa":"ORF1a: D3936N; ORF1b: S1898F, V2501I"}}}]},{"name":"NODE_0000573","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.260836124420166}},"branch_attrs":{"mutations":{"nuc":["G16914T"]}},"children":[{"name":"AY.114","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.114"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.114"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.435910940170288}},"branch_attrs":{"mutations":{"nuc":["C884T","G19677T"],"ORF1a":["R207C"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1a: R207C; ORF1b: Q2070H"}}},{"name":"AY.85","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.85"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3503634929656982}},"branch_attrs":{"mutations":{"nuc":["A708G","C1825T","T17748A","C25810T","G26428T","C26873T"],"E":["V62F"],"ORF1a":["E148G"],"ORF3a":["L140F"]},"labels":{"aa":"E: V62F; ORF1a: E148G; ORF3a: L140F"}}}]},{"name":"NODE_0000574","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.015812635421753}},"branch_attrs":{"mutations":{"nuc":["A1C","C13168T","C23557T","G25996T"],"ORF3a":["V202L"]},"labels":{"aa":"ORF3a: V202L"}},"children":[{"name":"AY.121","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.121"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.015812635421753}},"branch_attrs":{"mutations":{}}},{"name":"AY.121.1","node_attrs":{"div":46,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.121.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-25"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4786581993103027}},"branch_attrs":{"mutations":{"nuc":["T209C","T6949C","C16726T","C19859T","C21648T","C27638T","C27737T","G28396A","G29690T"],"ORF1b":["H1087Y","A2131V"],"ORF7a":["A82V","T115I"],"ORF9b":["G38D"],"S":["T29I"]},"labels":{"aa":"ORF1b: H1087Y, A2131V; ORF7a: A82V, T115I; ORF9b: G38D; S: T29I","spike_mutations":"T29I"}}}]},{"name":"NODE_0000575","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5549795627593994}},"branch_attrs":{"mutations":{"nuc":["C1593T","A10323G","C21301A"],"ORF1a":["S443F","K3353R"],"ORF1b":["P2612T"]},"labels":{"aa":"ORF1a: S443F, K3353R; ORF1b: P2612T"}},"children":[{"name":"AY.124.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.124.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":35},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.1392822265625}},"branch_attrs":{"mutations":{"nuc":["C4276T","G25445T","G25720T","C26058T","G28628T"],"N":["A119S"],"ORF3a":["G18V","A110S"]},"labels":{"aa":"N: A119S; ORF3a: G18V, A110S"}}},{"name":"AY.124","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.124"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-23"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5549795627593994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000576","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.08727502822876}},"branch_attrs":{"mutations":{"nuc":["G15906T"],"ORF1b":["Q813H"]},"labels":{"aa":"ORF1b: Q813H"}},"children":[{"name":"AY.125","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.125"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.125"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.753838300704956}},"branch_attrs":{"mutations":{"nuc":["C745T","C6730T","C13944T","G18905A","G25471T","A26786G"],"ORF1b":["R1813H"],"ORF3a":["D27Y"]},"labels":{"aa":"ORF1b: R1813H; ORF3a: D27Y"}}},{"name":"AY.128","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.128"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.128"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.398505210876465}},"branch_attrs":{"mutations":{"nuc":["C2973T","G16795T","T28150C"],"ORF1a":["A903V"],"ORF1b":["V1110L"],"ORF8":["F86S"]},"labels":{"aa":"ORF1a: A903V; ORF1b: V1110L; ORF8: F86S"}}}]},{"name":"NODE_0000577","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.111449956893921}},"branch_attrs":{"mutations":{"nuc":["A1T","G25538T","C26054A"],"ORF3a":["G49V","T221K"]},"labels":{"aa":"ORF3a: G49V, T221K"}},"children":[{"name":"AY.127","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.127"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.111449956893921}},"branch_attrs":{"mutations":{}}},{"name":"AY.127.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.127.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.655613422393799}},"branch_attrs":{"mutations":{"nuc":["G242A","T7816C","A19445G","G23608T","C24138A","G28378T"],"ORF1b":["K1993R"],"ORF9b":["R32L"],"S":["T859N"]},"labels":{"aa":"ORF1b: K1993R; ORF9b: R32L; S: T859N","spike_mutations":"T859N"}}}]},{"name":"NODE_0000578","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.579427719116211}},"branch_attrs":{"mutations":{"nuc":["A1G","C5239T","T5514C"],"ORF1a":["V1750A"]},"labels":{"aa":"ORF1a: V1750A"}},"children":[{"name":"AY.29","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.29"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.579427719116211}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.29.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.29.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4895212650299072}},"branch_attrs":{"mutations":{"nuc":["G22081T"],"S":["Q173H"]},"labels":{"aa":"S: Q173H","spike_mutations":"Q173H"}}}]},{"name":"NODE_0000579","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0413548946380615}},"branch_attrs":{"mutations":{"nuc":["G2258A","C12073T","C15237T","C25872T"],"ORF1a":["V665I"]},"labels":{"aa":"ORF1a: V665I"}},"children":[{"name":"AY.42.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.42.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7342679500579834}},"branch_attrs":{"mutations":{"nuc":["T4081A","C23718T","C24374T"],"ORF1a":["S1272R"],"S":["T719I","L938F"]},"labels":{"aa":"ORF1a: S1272R; S: T719I, L938F","spike_mutations":"T719I, L938F"}}},{"name":"AY.42","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.42"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0413548946380615}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000580","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.57420015335083}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}},"children":[{"name":"AY.113","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.113"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.113"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0687098503112793}},"branch_attrs":{"mutations":{"nuc":["A1G","C9165T","A10323G","A12772G"],"ORF1a":["T2967I","K3353R"]},"labels":{"aa":"ORF1a: T2967I, K3353R"}}},{"name":"NODE_0000581","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5571038722991943}},"branch_attrs":{"mutations":{"nuc":["C9559T","T28007C"]}},"children":[{"name":"AY.100","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.100"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.100"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.274301290512085}},"branch_attrs":{"mutations":{"nuc":["G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}}},{"name":"AY.101","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.101"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.101"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.416262626647949}},"branch_attrs":{"mutations":{"nuc":["C925T","C9474T","C25460T"],"ORF1a":["A3070V"],"ORF3a":["A23V"]},"labels":{"aa":"ORF1a: A3070V; ORF3a: A23V"}}}]}]},{"name":"NODE_0000582","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9556076526641846}},"branch_attrs":{"mutations":{"nuc":["C8829T","G19006T"],"ORF1a":["A2855V"],"ORF1b":["A1847S"]},"labels":{"aa":"ORF1a: A2855V; ORF1b: A1847S"}},"children":[{"name":"AY.119","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-04"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9556076526641846}},"branch_attrs":{"mutations":{}}},{"name":"AY.119.1","node_attrs":{"div":44,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":38},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.377321720123291}},"branch_attrs":{"mutations":{"nuc":["C100T","C2973T","G17338T","C22227T","T24063C","G25552T","G26031T","T26621C","G29392T"],"N":["K373N"],"ORF1a":["A903V"],"ORF1b":["A1291S"],"ORF3a":["A54S","Q213H"],"S":["A222V","I834T"]},"labels":{"aa":"N: K373N; ORF1a: A903V; ORF1b: A1291S; ORF3a: A54S, Q213H; S: A222V, I834T","spike_mutations":"A222V, I834T"}}},{"name":"AY.119.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1326918601989746}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000583","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.408951759338379}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"AY.36","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.36"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9737071990966797}},"branch_attrs":{"mutations":{"nuc":["T15628C","G18079T","A20532G","C29738T"],"ORF1b":["C721R","V1538L"]},"labels":{"aa":"ORF1b: C721R, V1538L"}}},{"name":"NODE_0000584","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.006218194961548}},"branch_attrs":{"mutations":{"nuc":["C2061T"],"ORF1a":["A599V"]},"labels":{"aa":"ORF1a: A599V"}},"children":[{"name":"AY.20","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.20"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.006218194961548}},"branch_attrs":{"mutations":{}}},{"name":"AY.20.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.20.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6867918968200684}},"branch_attrs":{"mutations":{"nuc":["C8880T","G9190T","C11173T","C24106T","G25481T","C27393T","G29737T"],"ORF1a":["T2872M"],"ORF3a":["R30L"]},"labels":{"aa":"ORF1a: T2872M; ORF3a: R30L"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1764931678771973}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"AY.22","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.22"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.319343566894531}},"branch_attrs":{"mutations":{"nuc":["T12496C","G14209T","A21987G","G22216T","G24872T","G26062T"],"ORF1b":["V248F"],"ORF3a":["G224C"],"S":["D142G","Q218H","V1104L"]},"labels":{"aa":"ORF1b: V248F; ORF3a: G224C; S: D142G, Q218H, V1104L","spike_mutations":"D142G, Q218H, V1104L"}}},{"name":"NODE_0000586","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5547027587890625}},"branch_attrs":{"mutations":{"nuc":["G1495T","A27690T","C29836T"]}},"children":[{"name":"AY.102","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5547027587890625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000587","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.114130020141602}},"branch_attrs":{"mutations":{"nuc":["A21987G","T25333C","A29700G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.102.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-5.037963390350342}},"branch_attrs":{"mutations":{"nuc":["G25218T"],"S":["G1219V"]},"labels":{"aa":"S: G1219V","spike_mutations":"G1219V"}}},{"name":"AY.102.2","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.796270847320557}},"branch_attrs":{"mutations":{"nuc":["C26395A","G29861T","G29862A","T29867-"],"E":["L51I"]},"labels":{"aa":"E: L51I"}}}]}]}]},{"name":"NODE_0000588","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0078787803649902}},"branch_attrs":{"mutations":{"nuc":["C6408T","A25003G"],"ORF1a":["S2048F"]},"labels":{"aa":"ORF1a: S2048F"}},"children":[{"name":"AY.120","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0078787803649902}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.1","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5417470932006836}},"branch_attrs":{"mutations":{"nuc":["C11095T"]}}},{"name":"NODE_0000589","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.590936183929443}},"branch_attrs":{"mutations":{"nuc":["G174T","C21758T"],"S":["H66Y"]},"labels":{"aa":"S: H66Y","spike_mutations":"H66Y"}},"children":[{"name":"AY.120.2","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.590936183929443}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.2.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.8597543239593506}},"branch_attrs":{"mutations":{"nuc":["C7105T","C13138T","T27017A"]}}}]}]},{"name":"NODE_0000590","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.438511610031128}},"branch_attrs":{"mutations":{"nuc":["A1G","G9441T","G18255T","C22498T","G23593C","G26109A","C26681T","G27014T"],"ORF1a":["C3059F"],"ORF1b":["M1596I"],"S":["Q677H"]},"labels":{"aa":"ORF1a: C3059F; ORF1b: M1596I; S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"AY.34","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.438511610031128}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.2","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":35},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.642725944519043}},"branch_attrs":{"mutations":{"nuc":["G11417T","A14457G","C21110T","C24138T"],"ORF1a":["V3718F"],"ORF1b":["T2548I"],"S":["T859I"]},"labels":{"aa":"ORF1a: V3718F; ORF1b: T2548I; S: T859I","spike_mutations":"T859I"}}},{"name":"NODE_0000591","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6367361545562744}},"branch_attrs":{"mutations":{"nuc":["C25355T","C28961T"],"N":["L230F"],"S":["L1265F"]},"labels":{"aa":"N: L230F; S: L1265F","spike_mutations":"L1265F"}},"children":[{"name":"AY.34.1.1","node_attrs":{"div":46,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.820716381072998}},"branch_attrs":{"mutations":{"nuc":["C2106T","G8017T","A21987G"],"ORF1a":["T614I"],"S":["D142G"]},"labels":{"aa":"ORF1a: T614I; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.34.1","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6367361545562744}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000592","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.79569411277771}},"branch_attrs":{"mutations":{"nuc":["G21372T","G27604A"],"ORF1b":["Q2635H"],"ORF7a":["V71I"]},"labels":{"aa":"ORF1b: Q2635H; ORF7a: V71I"}},"children":[{"name":"AY.39","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.79569411277771}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.2","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7347331047058105}},"branch_attrs":{"mutations":{"nuc":["G2494T","G5716T","C6883T","A21987G","G24781C"],"ORF1a":["E743D","K1817N"],"S":["D142G","K1073N"]},"labels":{"aa":"ORF1a: E743D, K1817N; S: D142G, K1073N","spike_mutations":"D142G, K1073N"}}},{"name":"NODE_0000593","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.059364080429077}},"branch_attrs":{"mutations":{"nuc":["A13482G"]}},"children":[{"name":"AY.39.1.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:78-122"},"partiallyAliased":{"value":"B.1.617.2.39.1.3"},"totalAminoacidDeletions":{"value":11},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.902846097946167}},"branch_attrs":{"mutations":{"nuc":["G2164T","A21987G","C25046G","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF1a":["E633D"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"S":["D142G","P1162A"]},"labels":{"aa":"ORF1a: E633D; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; S: D142G, P1162A","spike_mutations":"D142G, P1162A"}}},{"name":"AY.39.1.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:78-122"},"partiallyAliased":{"value":"B.1.617.2.39.1.2"},"totalAminoacidDeletions":{"value":11},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.295774221420288}},"branch_attrs":{"mutations":{"nuc":["G1577A","C18555T","C25568T","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF1a":["V438I"],"ORF3a":["A59V"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"]},"labels":{"aa":"ORF1a: V438I; ORF3a: A59V; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-"}}},{"name":"AY.39.1","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.059364080429077}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.1.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3977465629577637}},"branch_attrs":{"mutations":{"nuc":["G19563T"],"ORF1b":["L2032F"]},"labels":{"aa":"ORF1b: L2032F"}}}]}]},{"name":"NODE_0000594","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7977098226547241}},"branch_attrs":{"mutations":{"nuc":["C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}},"children":[{"name":"AY.4","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7977098226547241}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.10","node_attrs":{"div":44,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.10"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-22"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.931220293045044}},"branch_attrs":{"mutations":{"nuc":["C4320T","C5512T","T8604C","C10714T","C12513T","A16602G","G20663A","C23996T","G25757T","T27900C"],"ORF1a":["A1352V","F2780S","T4083M"],"ORF1b":["S2399N"],"ORF3a":["R122I"],"ORF8":["F3L"],"S":["P812S"]},"labels":{"aa":"ORF1a: A1352V, F2780S, T4083M; ORF1b: S2399N; ORF3a: R122I; ORF8: F3L; S: P812S","spike_mutations":"P812S"}}},{"name":"AY.4.4","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6386144161224365}},"branch_attrs":{"mutations":{"nuc":["G14209T","C21575T","C22000T","G24348C"],"ORF1b":["V248F"],"S":["L5F","S929T"]},"labels":{"aa":"ORF1b: V248F; S: L5F, S929T","spike_mutations":"L5F, S929T"}}},{"name":"AY.4.3","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-08"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5429084300994873}},"branch_attrs":{"mutations":{"nuc":["C21638T"],"S":["P26S"]},"labels":{"aa":"S: P26S","spike_mutations":"P26S"}}},{"name":"AY.4.5","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.983483076095581}},"branch_attrs":{"mutations":{"nuc":["A14882C","G25337T"],"ORF1b":["D472A"],"S":["D1259Y"]},"labels":{"aa":"ORF1b: D472A; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"AY.4.7","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.372633218765259}},"branch_attrs":{"mutations":{"nuc":["A1T","G14829T","G17193T","G26416T","C28291T"],"E":["V58F"],"ORF1b":["M454I","E1242D"],"ORF9b":["P3L"]},"labels":{"aa":"E: V58F; ORF1b: M454I, E1242D; ORF9b: P3L"}}},{"name":"AY.4.8","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.8"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.532318353652954}},"branch_attrs":{"mutations":{"nuc":["C2706T","C11450A","A12124G","G25489T","C29774T"],"ORF1a":["T814I","Q3729K"],"ORF3a":["A33S"]},"labels":{"aa":"ORF1a: T814I, Q3729K; ORF3a: A33S"}}},{"name":"NODE_0000595","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.684542179107666}},"branch_attrs":{"mutations":{"nuc":["T17040C"]}},"children":[{"name":"AY.4.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.0368428230285645}},"branch_attrs":{"mutations":{"nuc":["C2706T","T18927C","A20374C","G22899T"],"ORF1a":["T814I"],"ORF1b":["I2303L"],"S":["G446V"]},"labels":{"aa":"ORF1a: T814I; ORF1b: I2303L; S: G446V","spike_mutations":"G446V"}}},{"name":"AY.4.6","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1065709590911865}},"branch_attrs":{"mutations":{"nuc":["C16293T","C19524T","C20404T","A28967G"],"N":["S232G"],"ORF1b":["P2313S"]},"labels":{"aa":"N: S232G; ORF1b: P2313S"}}},{"name":"AY.4.9","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.9"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-22"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.86684250831604}},"branch_attrs":{"mutations":{"nuc":["C3140T","T4066A","C12513T"],"ORF1a":["P959S","T4083M"]},"labels":{"aa":"ORF1a: P959S, T4083M"}}},{"name":"NODE_0000596","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.5733251571655273}},"branch_attrs":{"mutations":{"nuc":["T21995C","C22227T","C25614T"],"S":["Y145H","A222V"]},"labels":{"aa":"S: Y145H, A222V","spike_mutations":"Y145H, A222V"}},"children":[{"name":"AY.4.2","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-04"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.5733251571655273}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.2.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4524967670440674}},"branch_attrs":{"mutations":{"nuc":["G26526T"],"M":["A2S"]},"labels":{"aa":"M: A2S"}}},{"name":"AY.4.2.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.774232864379883}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"AY.4.2.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.891268491744995}},"branch_attrs":{"mutations":{"nuc":["C15720T","C18687T","G21668T","G28878T"],"N":["S202I"],"S":["V36F"]},"labels":{"aa":"N: S202I; S: V36F","spike_mutations":"V36F"}}}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000597","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{"nuc":["G28881A","G28882A","G28883C"],"N":["R203K","G204R"]},"labels":{"aa":"N: R203K, G204R","clade":"20B"}},"children":[{"name":"B.1.1","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.111","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.111"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.111"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.088804244995117}},"branch_attrs":{"mutations":{"nuc":["T27447C","T29661C"]}}},{"name":"B.1.1.115","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.115"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.115"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5503621101379395}},"branch_attrs":{"mutations":{"nuc":["G26918T","T29464C"]}}},{"name":"B.1.1.101","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.101"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.101"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.795865058898926}},"branch_attrs":{"mutations":{"nuc":["G8371T","G29868A"],"ORF1a":["Q2702H"]},"labels":{"aa":"ORF1a: Q2702H"}}},{"name":"B.1.1.117","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.117"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.117"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5670976638793945}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"B.1.1.135","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.135"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.135"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.479676723480225}},"branch_attrs":{"mutations":{"nuc":["C10376T"],"ORF1a":["P3371S"]},"labels":{"aa":"ORF1a: P3371S"}}},{"name":"B.1.1.121","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.121"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.121"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.165002346038818}},"branch_attrs":{"mutations":{"nuc":["C27538T"]}}},{"name":"B.1.1.133","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.133"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.133"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4965T","A8072G","A16011G","A21213G"],"ORF1a":["T1567I","N2603D"]},"labels":{"aa":"ORF1a: T1567I, N2603D"}}},{"name":"B.1.1.141","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.141"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.141"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.263731002807617}},"branch_attrs":{"mutations":{"nuc":["T22020C","G26056T"],"ORF3a":["D222Y"],"S":["M153T"]},"labels":{"aa":"ORF3a: D222Y; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.157","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.157"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.157"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.143161773681641}},"branch_attrs":{"mutations":{"nuc":["C6145T","G11272A","C17678T"],"ORF1a":["M3669I"],"ORF1b":["T1404M"]},"labels":{"aa":"ORF1a: M3669I; ORF1b: T1404M"}}},{"name":"B.1.1.161","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.161"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.161"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.087497711181641}},"branch_attrs":{"mutations":{"nuc":["G23403A"],"S":["G614D"]},"labels":{"aa":"S: G614D","spike_mutations":"G614D"}}},{"name":"B.1.1.171","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.171"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.171"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7598371505737305}},"branch_attrs":{"mutations":{"nuc":["C1437T","G29745T"],"ORF1a":["S391F"]},"labels":{"aa":"ORF1a: S391F"}}},{"name":"B.1.1.163","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.163"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.163"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.996797561645508}},"branch_attrs":{"mutations":{"nuc":["G11029A","C21772T","C29518T"]}}},{"name":"B.1.1.174","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.174"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.174"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.569986343383789}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.1.176","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.176"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.176"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.818801164627075}},"branch_attrs":{"mutations":{"nuc":["C8208T","G9267A","T9667C","G25947T","G28361A"],"N":["G30R"],"ORF1a":["T2648I","S3001N"],"ORF3a":["Q185H"],"ORF9b":["M26I"]},"labels":{"aa":"N: G30R; ORF1a: T2648I, S3001N; ORF3a: Q185H; ORF9b: M26I"}}},{"name":"B.1.1.186","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.186"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.186"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.552790641784668}},"branch_attrs":{"mutations":{"nuc":["C4113T","G21974C","C23191T"],"ORF1a":["A1283V"],"S":["D138H"]},"labels":{"aa":"ORF1a: A1283V; S: D138H","spike_mutations":"D138H"}}},{"name":"B.1.1.189","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.189"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.189"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.426567554473877}},"branch_attrs":{"mutations":{"nuc":["C9430T","C12823T"]}}},{"name":"B.1.1.192","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.192"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.192"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.35951042175293}},"branch_attrs":{"mutations":{"nuc":["A1G","C673T"]}}},{"name":"B.1.1.203","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.203"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.203"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.922868251800537}},"branch_attrs":{"mutations":{"nuc":["C23854T"]}}},{"name":"B.1.1.207","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.207"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.207"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.143320560455322}},"branch_attrs":{"mutations":{"nuc":["T9172C","A10948G","C10977T","C23604A","A24874G","G26730T","A26927G"],"M":["V70F"],"ORF1a":["A3571V"],"S":["P681H"]},"labels":{"aa":"M: V70F; ORF1a: A3571V; S: P681H","spike_mutations":"P681H"}}},{"name":"B.1.1.198","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.198"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.198"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.466541767120361}},"branch_attrs":{"mutations":{"nuc":["C3261T","A15984T","C20946T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}}},{"name":"B.1.1.205","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.205"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.205"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7890214920043945}},"branch_attrs":{"mutations":{"nuc":["G5539A","G21468A"],"ORF1b":["M2667I"]},"labels":{"aa":"ORF1b: M2667I"}}},{"name":"B.1.1.228","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.228"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.228"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.376809597015381}},"branch_attrs":{"mutations":{"nuc":["A20288G","C21721T","C26894T","C28638A"],"N":["P122H"],"ORF1b":["E2274G"]},"labels":{"aa":"N: P122H; ORF1b: E2274G"}}},{"name":"B.1.1.232","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.232"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.232"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.283544063568115}},"branch_attrs":{"mutations":{"nuc":["T2537G","G12191T","T16479C"],"ORF1a":["L758V","V3976F"]},"labels":{"aa":"ORF1a: L758V, V3976F"}}},{"name":"B.1.1.231","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.231"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.231"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.253881931304932}},"branch_attrs":{"mutations":{"nuc":["A1G","A25505C"],"ORF3a":["Q38P"]},"labels":{"aa":"ORF3a: Q38P"}}},{"name":"B.1.1.253","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.253"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.253"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5750203132629395}},"branch_attrs":{"mutations":{"nuc":["T19893C"]}}},{"name":"B.1.1.241","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.241"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.241"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.247255802154541}},"branch_attrs":{"mutations":{"nuc":["A11782G","T21570G","C21575T","T25473C","C28253T"],"S":["V3G","L5F"]},"labels":{"aa":"S: V3G, L5F","spike_mutations":"V3G, L5F"}}},{"name":"B.1.1.243","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.243"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.243"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7952799797058105}},"branch_attrs":{"mutations":{"nuc":["C5339T","A9900C","C12733A"],"ORF1a":["P1692S","N3212T"]},"labels":{"aa":"ORF1a: P1692S, N3212T"}}},{"name":"B.1.1.263","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.263"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.263"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.34738302230835}},"branch_attrs":{"mutations":{"nuc":["G5924A","T21775G"],"ORF1a":["V1887I"]},"labels":{"aa":"ORF1a: V1887I"}}},{"name":"B.1.1.265","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.265"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.265"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.462660312652588}},"branch_attrs":{"mutations":{"nuc":["C11005A","A28624T"],"ORF1a":["H3580Q"]},"labels":{"aa":"ORF1a: H3580Q"}}},{"name":"B.1.1.269","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.269"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.269"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.337713718414307}},"branch_attrs":{"mutations":{"nuc":["C5055T","G11851T","G24812T","C26895T"],"M":["H125Y"],"ORF1a":["T1597I","M3862I"],"S":["D1084Y"]},"labels":{"aa":"M: H125Y; ORF1a: T1597I, M3862I; S: D1084Y","spike_mutations":"D1084Y"}}},{"name":"B.1.1.277","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.277"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.277"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1255927085876465}},"branch_attrs":{"mutations":{"nuc":["A1G","T772C","A2869G","C10868T","G15652T","C29095T"],"ORF1b":["D729Y"]},"labels":{"aa":"ORF1b: D729Y"}}},{"name":"B.1.1.274","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.274"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.274"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.412598133087158}},"branch_attrs":{"mutations":{"nuc":["G25912T"],"ORF3a":["G174C"]},"labels":{"aa":"ORF3a: G174C"}}},{"name":"B.1.1.298","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.298"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.298"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.084219455718994}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22920T","C25936T"],"ORF1b":["T730I"],"ORF3a":["H182Y"],"S":["Y453F"]},"labels":{"aa":"ORF1b: T730I; ORF3a: H182Y; S: Y453F","spike_mutations":"Y453F"}}},{"name":"B.1.1.297","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.297"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.297"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.437381267547607}},"branch_attrs":{"mutations":{"nuc":["A20742C","T27922C"],"ORF1b":["Q2425H"],"ORF8":["I10T"]},"labels":{"aa":"ORF1b: Q2425H; ORF8: I10T"}}},{"name":"B.1.1.294","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.294"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.294"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.174857139587402}},"branch_attrs":{"mutations":{"nuc":["C3373A","C6883T","G21724A"],"ORF1a":["D1036E"]},"labels":{"aa":"ORF1a: D1036E"}}},{"name":"B.1.1.307","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.307"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.307"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8598484992980957}},"branch_attrs":{"mutations":{"nuc":["G1210T","G9802T","G12067T"],"ORF1a":["M315I","M3934I"]},"labels":{"aa":"ORF1a: M315I, M3934I"}}},{"name":"B.1.1.311","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.311"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.311"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8074538707733154}},"branch_attrs":{"mutations":{"nuc":["G11230T","T24088C","G25617T"],"ORF1a":["M3655I"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1a: M3655I; ORF3a: K75N"}}},{"name":"B.1.1.329","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.329"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.329"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.522205352783203}},"branch_attrs":{"mutations":{"nuc":["A2132C","A10323G","G10360A"],"ORF1a":["K623Q","K3353R"]},"labels":{"aa":"ORF1a: K623Q, K3353R"}}},{"name":"B.1.1.348","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.348"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.348"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.965911388397217}},"branch_attrs":{"mutations":{"nuc":["C25521T","C29870A"]}}},{"name":"B.1.1.359","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.359"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.359"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.385677337646484}},"branch_attrs":{"mutations":{"nuc":["A28305G"],"N":["N11S"],"ORF9b":["M8V"]},"labels":{"aa":"N: N11S; ORF9b: M8V"}}},{"name":"B.1.1.37","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.37"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.37"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.5076286792755127}},"branch_attrs":{"mutations":{"nuc":["C21637T","A28169G"]}}},{"name":"B.1.1.368","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.368"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.368"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.436727523803711}},"branch_attrs":{"mutations":{"nuc":["C9996T","G27798T","G29402T"],"N":["D377Y"],"ORF1a":["S3244L"],"ORF7b":["A15S"]},"labels":{"aa":"N: D377Y; ORF1a: S3244L; ORF7b: A15S"}}},{"name":"B.1.1.370","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.370"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.370"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.374","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.374"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.374"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C344A","T1456C","C8595T","C8836T","G11222T","C22792T","T22917A","T26047G"],"ORF1a":["L27I","T2777I","V3653F"],"ORF3a":["L219V"],"S":["L452Q"]},"labels":{"aa":"ORF1a: L27I, T2777I, V3653F; ORF3a: L219V; S: L452Q","spike_mutations":"L452Q"}}},{"name":"B.1.1.376","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.376"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.376"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.826653480529785}},"branch_attrs":{"mutations":{"nuc":["A6716G","G11596T"],"ORF1a":["S2151G","Q3777H"]},"labels":{"aa":"ORF1a: S2151G, Q3777H"}}},{"name":"B.1.1.39","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.39"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9360604286193848}},"branch_attrs":{"mutations":{"nuc":["G9130T","T27319C","G28487A","C28868T"],"N":["V72I","P199S"]},"labels":{"aa":"N: V72I, P199S"}}},{"name":"B.1.1.378","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.378"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.378"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.596437454223633}},"branch_attrs":{"mutations":{"nuc":["C29284T","C29870A"]}}},{"name":"B.1.1.391","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.391"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.391"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.078312397003174}},"branch_attrs":{"mutations":{"nuc":["T7171C","C27002T"]}}},{"name":"B.1.1.398","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.398"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.398"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.419233322143555}},"branch_attrs":{"mutations":{"nuc":["C5806T"]}}},{"name":"B.1.1.409","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.409"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.409"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.411","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.411"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.411"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.413","node_attrs":{"div":16,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.413"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.413"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A604G","C3096T","G13849T","A19020T","G21974T","G22992A","A26741G","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","C28291T","C29311T"],"M":["I73M"],"ORF1a":["S944L"],"ORF1b":["G128C"],"ORF8":["G66-","S67-","K68E"],"ORF9b":["P3L"],"S":["D138Y","S477N"]},"labels":{"aa":"M: I73M; ORF1a: S944L; ORF1b: G128C; ORF8: G66-, S67-, K68E; ORF9b: P3L; S: D138Y, S477N","spike_mutations":"D138Y, S477N"}}},{"name":"B.1.1.432","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.432"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.432"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.086132526397705}},"branch_attrs":{"mutations":{"nuc":["A6985T","C9319T","C12412T","T14313C"]}}},{"name":"B.1.1.419","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.419"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.419"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.420","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.420"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.420"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.130890846252441}},"branch_attrs":{"mutations":{"nuc":["T847C","G3994T","C5178T","C5548T","A11451G","C13694T","T18132C","C21614T","T22882G","A24373G","G25839T","C28310T","T28862A"],"N":["P13S","S197T"],"ORF1a":["T1638I","Q3729R"],"ORF1b":["T76I"],"ORF3a":["W149C"],"S":["L18F","N440K"]},"labels":{"aa":"N: P13S, S197T; ORF1a: T1638I, Q3729R; ORF1b: T76I; ORF3a: W149C; S: L18F, N440K","spike_mutations":"L18F, N440K"}}},{"name":"B.1.1.442","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.442"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.442"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.203185558319092}},"branch_attrs":{"mutations":{"nuc":["A3879-","G3880-","A3881-","T3882-","T3883-","C3884-","C3885-","T3886-","A3887-","A3888-","A3889-","G3890-","A3891-","G3892-","G3893-","A3894-","A3895-","G3896-","T3897-","T3898-","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","A3908-","C13432T","C29409T"],"N":["T379I"],"ORF1a":["E1205-","I1206-","P1207-","K1208-","E1209-","E1210-","V1211-","K1212-","P1213-","F1214-","I1215V"]},"labels":{"aa":"N: T379I; ORF1a: E1205-, I1206-, P1207-, K1208-, E1209-, E1210-, V1211-, K1212-, P1213-, F1214-, I1215V"}}},{"name":"B.1.1.44","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.44"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.44"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.21798849105835}},"branch_attrs":{"mutations":{"nuc":["G28884T"],"N":["R204L"]},"labels":{"aa":"N: R204L"}}},{"name":"B.1.1.485","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.485"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.485"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.884125232696533}},"branch_attrs":{"mutations":{"nuc":["C745T"]}}},{"name":"B.1.1.462","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.462"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.462"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.083774089813232}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.1.487","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.487"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.487"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.523555278778076}},"branch_attrs":{"mutations":{"nuc":["A20374G"],"ORF1b":["I2303V"]},"labels":{"aa":"ORF1b: I2303V"}}},{"name":"B.1.1.500","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.500"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.500"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.359643936157227}},"branch_attrs":{"mutations":{"nuc":["T23689C","C29230T"]}}},{"name":"B.1.1.52","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.52"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.52"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":1},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.163636207580566}},"branch_attrs":{"mutations":{"nuc":["G8T","T9C","A12T","T14222G","T29867A"],"ORF1b":["L252*"]},"labels":{"aa":"ORF1b: L252*"}}},{"name":"B.1.1.525","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.525"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.525"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-18"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1C","T2C","T3478G","C8299T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12781T","A16550C","C16887T","C18252T","T21992-","A21993-","T21994-","G23012A","C23525T","A28271C","G28916T"],"N":["G215C"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF1b":["D1028A"],"S":["Y144-","E484K","H655Y"]},"labels":{"aa":"N: G215C; ORF1a: S3675-, G3676-, F3677-; ORF1b: D1028A; S: Y144-, E484K, H655Y","spike_mutations":"Y144-, E484K, H655Y"}}},{"name":"B.1.1.53","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.53"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.53"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.883930683135986}},"branch_attrs":{"mutations":{"nuc":["G9890T","A20318G"],"ORF1a":["A3209S"],"ORF1b":["E2284G"]},"labels":{"aa":"ORF1a: A3209S; ORF1b: E2284G"}}},{"name":"B.1.1.57","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.57"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.57"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.499952793121338}},"branch_attrs":{"mutations":{"nuc":["C20234T"],"ORF1b":["P2256L"]},"labels":{"aa":"ORF1b: P2256L"}}},{"name":"B.1.1.61","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.61"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.61"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.901400566101074}},"branch_attrs":{"mutations":{"nuc":["G18898T"],"ORF1b":["V1811F"]},"labels":{"aa":"ORF1b: V1811F"}}},{"name":"B.1.1.63","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.63"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.63"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.753174304962158}},"branch_attrs":{"mutations":{"nuc":["C21597T","C29144T"],"S":["S12F"]},"labels":{"aa":"S: S12F","spike_mutations":"S12F"}}},{"name":"B.1.1.83","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.83"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.83"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.398312091827393}},"branch_attrs":{"mutations":{"nuc":["C1420T"]}}},{"name":"B.1.1.99","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.99"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.99"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.941136360168457}},"branch_attrs":{"mutations":{"nuc":["C28005T","C29870A"],"ORF8":["P38S"]},"labels":{"aa":"ORF8: P38S"}}},{"name":"B.1.533","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.533"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.533"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.077569961547852}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"NODE_0000598","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.773193359375}},"branch_attrs":{"mutations":{"nuc":["G26211T"]}},"children":[{"name":"AT.1","node_attrs":{"div":32,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.370.1"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-19"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1392T","G3281T","A3542G","A5176G","C7005A","T9070C","C9778T","C10029T","A11451G","T12620A","C16985A","G17562T","G19180T","C20759T","C21588T","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","A22206G","A22296C","G23012A","G23900A","C24370T","T25675A","C26568A","G28079T","A28271G"],"M":["L16I"],"ORF1a":["S376L","V1006F","T1093A","T2247N","T3255I","Q3729R","S4119T"],"ORF1b":["T1173N","V1905L","A2431V"],"ORF3a":["L95M"],"S":["P9L","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","D215G","H245P","E484K","E780K"]},"labels":{"aa":"M: L16I; ORF1a: S376L, V1006F, T1093A, T2247N, T3255I, Q3729R, S4119T; ORF1b: T1173N, V1905L, A2431V; ORF3a: L95M; S: P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K","spike_mutations":"P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K"}}},{"name":"B.1.1.404","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.404"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.404"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.654805660247803}},"branch_attrs":{"mutations":{"nuc":["T19275A","G20548T","C26534T"],"ORF1b":["D2361Y"]},"labels":{"aa":"ORF1b: D2361Y"}}}]},{"name":"NODE_0000599","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.10"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.217991828918457}},"branch_attrs":{"mutations":{"nuc":["C19170T","G19509A"]}},"children":[{"name":"B.1.1.10","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.217991828918457}},"branch_attrs":{"mutations":{}}},{"name":"L.3","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"L.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.10.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.097334861755371}},"branch_attrs":{"mutations":{"nuc":["C1601T","G4399T","C4543T","G8179T","C8481T","A9453C","C19269T","T22917G","A25026T","G25244T","A26927G"],"ORF1a":["L446F","M1378I","P2739L","Y3063S"],"S":["L452R","Y1155F","V1228L"]},"labels":{"aa":"ORF1a: L446F, M1378I, P2739L, Y3063S; S: L452R, Y1155F, V1228L","spike_mutations":"L452R, Y1155F, V1228L"}}}]},{"name":"NODE_0000600","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.581684589385986}},"branch_attrs":{"mutations":{"nuc":["C9120T"],"ORF1a":["T2952I"]},"labels":{"aa":"ORF1a: T2952I"}},"children":[{"name":"B.1.1.159","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.159"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.159"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.9156622886657715}},"branch_attrs":{"mutations":{"nuc":["G6865T","A9204C","C15237T","C28290T"],"N":["P6L"],"ORF1a":["K2200N","D2980A"],"ORF9b":["P3S"]},"labels":{"aa":"N: P6L; ORF1a: K2200N, D2980A; ORF9b: P3S"}}},{"name":"B.1.1.302","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.302"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.302"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.444321632385254}},"branch_attrs":{"mutations":{"nuc":["C7267T","C18032T","C20233T","G24926T","A27674T","A29350G"],"ORF1b":["T1522I","P2256S"],"ORF7a":["Q94L"],"S":["V1122L"]},"labels":{"aa":"ORF1b: T1522I, P2256S; ORF7a: Q94L; S: V1122L","spike_mutations":"V1122L"}}}]},{"name":"NODE_0000601","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.953939437866211}},"branch_attrs":{"mutations":{"nuc":["C1427T"],"ORF1a":["H388Y"]},"labels":{"aa":"ORF1a: H388Y"}},"children":[{"name":"B.1.1.254","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.254"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.254"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.953939437866211}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.507","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.507"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.507"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.39810848236084}},"branch_attrs":{"mutations":{"nuc":["G1042A","C12253T","G19656A"]}}}]},{"name":"NODE_0000602","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.189764499664307}},"branch_attrs":{"mutations":{"nuc":["G21624T"],"S":["R21I"]},"labels":{"aa":"S: R21I","spike_mutations":"R21I"}},"children":[{"name":"B.1.1.279","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.279"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.279"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.194469451904297}},"branch_attrs":{"mutations":{"nuc":["C1419T","C4158T","C8318A","G18859T"],"ORF1a":["A385V","A1298V","P2685T"],"ORF1b":["A1798S"]},"labels":{"aa":"ORF1a: A385V, A1298V, P2685T; ORF1b: A1798S"}}},{"name":"B.1.1.360","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.360"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.360"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.070791721343994}},"branch_attrs":{"mutations":{"nuc":["G25598T"],"ORF3a":["W69L"]},"labels":{"aa":"ORF3a: W69L"}}}]},{"name":"NODE_0000603","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.919500827789307}},"branch_attrs":{"mutations":{"nuc":["C936T","G3259T"],"ORF1a":["T224I","Q998H"]},"labels":{"aa":"ORF1a: T224I, Q998H"}},"children":[{"name":"B.1.1.304","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.304"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.304"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.919500827789307}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.434","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.434"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.434"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2342G","C11591T","G17122T","C18348T","A26069G"],"ORF1a":["I693V","L3776F"],"ORF1b":["A1219S"],"ORF3a":["E226G"]},"labels":{"aa":"ORF1a: I693V, L3776F; ORF1b: A1219S; ORF3a: E226G"}}}]},{"name":"NODE_0000604","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986992835998535}},"branch_attrs":{"mutations":{"nuc":["C25528T"],"ORF3a":["L46F"]},"labels":{"aa":"ORF3a: L46F"}},"children":[{"name":"B.1.1.326","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.326"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.326"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.312770843505859}},"branch_attrs":{"mutations":{"nuc":["A12C","G4354A","C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}}},{"name":"B.1.1.8","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986992835998535}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000605","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.15211820602417}},"branch_attrs":{"mutations":{"nuc":["G16853T"],"ORF1b":["G1129V"]},"labels":{"aa":"ORF1b: G1129V"}},"children":[{"name":"B.1.1.34","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.34"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.34"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.187512397766113}},"branch_attrs":{"mutations":{"nuc":["C2094T"],"ORF1a":["S610L"]},"labels":{"aa":"ORF1a: S610L"}}},{"name":"B.1.1.382","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.382"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.382"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.577414035797119}},"branch_attrs":{"mutations":{"nuc":["G6368A"],"ORF1a":["G2035R"]},"labels":{"aa":"ORF1a: G2035R"}}}]},{"name":"NODE_0000606","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.365635395050049}},"branch_attrs":{"mutations":{"nuc":["G28077T"],"ORF8":["V62L"]},"labels":{"aa":"ORF8: V62L"}},"children":[{"name":"B.1.1.397","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.397"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.397"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4799723625183105}},"branch_attrs":{"mutations":{"nuc":["G21974T","T22020C","G28975T"],"N":["M234I"],"S":["D138Y","M153T"]},"labels":{"aa":"N: M234I; S: D138Y, M153T","spike_mutations":"D138Y, M153T"}}},{"name":"B.1.1.526","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.526"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.526"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-25"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-8.3259916305542}},"branch_attrs":{"mutations":{"nuc":["G4510T","C8917T","G9389A","C9611T","G12167T","G14622A","C23604A","T24811C","G25250T","G25906T","C29659T"],"ORF1a":["D3042N","L3116F","V3968F"],"ORF3a":["G172C"],"S":["P681H","V1230L"]},"labels":{"aa":"ORF1a: D3042N, L3116F, V3968F; ORF3a: G172C; S: P681H, V1230L","spike_mutations":"P681H, V1230L"}}}]},{"name":"NODE_0000607","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.675731658935547}},"branch_attrs":{"mutations":{"nuc":["T12503C","C29721T"],"ORF1a":["Y4080H"]},"labels":{"aa":"ORF1a: Y4080H"}},"children":[{"name":"B.1.1.448","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.448"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.448"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.675731658935547}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.54","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.54"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.54"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.6780924797058105}},"branch_attrs":{"mutations":{"nuc":["C6762T","G25770T"],"ORF1a":["T2166I"],"ORF3a":["R126S"]},"labels":{"aa":"ORF1a: T2166I; ORF3a: R126S"}}}]},{"name":"NODE_0000608","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.731308460235596}},"branch_attrs":{"mutations":{"nuc":["C21648T"],"S":["T29I"]},"labels":{"aa":"S: T29I","spike_mutations":"T29I"}},"children":[{"name":"B.1.1.486","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.486"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.486"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["C12439T","C23277T","G23593T","G24368A","G25565A","C25624T","T27242C","C27630T","G28975T","G29332T","G29751T"],"N":["M234I"],"ORF3a":["S58N","H78Y"],"ORF6":["I14T"],"S":["T572I","Q677H","D936N"]},"labels":{"aa":"N: M234I; ORF3a: S58N, H78Y; ORF6: I14T; S: T572I, Q677H, D936N","spike_mutations":"T572I, Q677H, D936N"}}},{"name":"B.1.1.67","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.67"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.67"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.89309549331665}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"ORF1a":["D3728N"]},"labels":{"aa":"ORF1a: D3728N"}}}]},{"name":"NODE_0000609","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.003873348236084}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"B.1.1.371","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.371"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.371"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.003873348236084}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000610","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-7.580465316772461}},"branch_attrs":{"mutations":{"nuc":["C13887T","C23248T"]}},"children":[{"name":"B.1.1.153","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.153"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.153"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C1912T","T9151C","C9693T"],"ORF1a":["A3143V"]},"labels":{"aa":"ORF1a: A3143V"}}},{"name":"B.1.1.170","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.170"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.170"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.357182025909424}},"branch_attrs":{"mutations":{"nuc":["C2062T","C5184A","C16456T","C18687T"],"ORF1a":["P1640H"],"ORF1b":["P997S"]},"labels":{"aa":"ORF1a: P1640H; ORF1b: P997S"}}}]}]},{"name":"NODE_0000611","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.207353591918945}},"branch_attrs":{"mutations":{"nuc":["C26060T"],"ORF3a":["T223I"]},"labels":{"aa":"ORF3a: T223I"}},"children":[{"name":"B.1.1.216","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.216"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.216"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.874288558959961}},"branch_attrs":{"mutations":{"nuc":["A1T","C5884T"]}}},{"name":"B.1.1.416","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.416"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.416"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.053168773651123}},"branch_attrs":{"mutations":{"nuc":["C16386T","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"B.1.1.433","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.433"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.433"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.377383232116699}},"branch_attrs":{"mutations":{"nuc":["C313T","G3692T","C5007T","A11991G","G14584A","C14805T","T15114C","C15848T","G20940T","C22993G","G23580C","T23599A","G26217T","G26951C","T27900C"],"ORF1a":["V1143F","T1581M","E3909G"],"ORF1b":["A373T","T794I"],"ORF3a":["L275F"],"ORF8":["F3L"],"S":["S477R","S673T","N679K"]},"labels":{"aa":"ORF1a: V1143F, T1581M, E3909G; ORF1b: A373T, T794I; ORF3a: L275F; ORF8: F3L; S: S477R, S673T, N679K","spike_mutations":"S477R, S673T, N679K"}}}]},{"name":"NODE_0000612","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.322074890136719}},"branch_attrs":{"mutations":{"nuc":["G10265A"],"ORF1a":["G3334S"]},"labels":{"aa":"ORF1a: G3334S"}},"children":[{"name":"B.1.1.27","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.27"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.27"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.765736103057861}},"branch_attrs":{"mutations":{"nuc":["C16293T"]}}},{"name":"B.1.1.301","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.301"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.301"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.301371097564697}},"branch_attrs":{"mutations":{"nuc":["A9433T","A19650G"]}}},{"name":"B.1.1.70","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.70"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.70"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.566112756729126}},"branch_attrs":{"mutations":{"nuc":["A15972G","C19718T","T28759C"],"ORF1b":["T2084I"]},"labels":{"aa":"ORF1b: T2084I"}}}]},{"name":"NODE_0000613","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.842899322509766}},"branch_attrs":{"mutations":{"nuc":["C22675T"]}},"children":[{"name":"B.1.1.273","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.273"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.273"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.872927665710449}},"branch_attrs":{"mutations":{"nuc":["A7064G"],"ORF1a":["R2267G"]},"labels":{"aa":"ORF1a: R2267G"}}},{"name":"B.1.1.412","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.412"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.412"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986691951751709}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"ORF1a":["D3728N"]},"labels":{"aa":"ORF1a: D3728N"}}},{"name":"B.1.1.56","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.56"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.56"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.680346488952637}},"branch_attrs":{"mutations":{"nuc":["T9508C","G23868T","G24794T"],"S":["G769V","A1078S"]},"labels":{"aa":"S: G769V, A1078S","spike_mutations":"G769V, A1078S"}}}]},{"name":"NODE_0000614","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879861831665039}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"B.1.1.312","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.312"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.312"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420843601226807}},"branch_attrs":{"mutations":{"nuc":["C2455T","C14625T","C19018T","A24432T","A28081G"],"ORF1b":["P1851S"],"ORF8":["D63G"],"S":["Q957L"]},"labels":{"aa":"ORF1b: P1851S; ORF8: D63G; S: Q957L","spike_mutations":"Q957L"}}},{"name":"B.1.1.406","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.406"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.406"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.854406833648682}},"branch_attrs":{"mutations":{"nuc":["C683T","C7051T","C7303T","C8964T","G25314T","C29296T","G29744A"],"ORF1a":["S2900L"],"S":["G1251V"]},"labels":{"aa":"ORF1a: S2900L; S: G1251V","spike_mutations":"G1251V"}}},{"name":"B.1.1.417","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.417"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.417"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.553449630737305}},"branch_attrs":{"mutations":{"nuc":["A2871G","C11455T","T12433C","C16997T","C17285T","A17739G","C19017T","G19072T","C20823T","G21800T","C25416T","G29781T"],"ORF1a":["N869S"],"ORF1b":["P1177L","S1273L","D1869Y"],"S":["D80Y"]},"labels":{"aa":"ORF1a: N869S; ORF1b: P1177L, S1273L, D1869Y; S: D80Y","spike_mutations":"D80Y"}}}]},{"name":"NODE_0000615","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.0597028732299805}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}},"children":[{"name":"B.1.1.351","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.351"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.351"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C7231T","A9749G","C10776A","A13867C","A15489G","C16658T","G17815A","C19164T","G21724T","C23604A"],"ORF1a":["K3162E","P3504H"],"ORF1b":["K134Q","T1064I","G1450R"],"S":["L54F","P681H"]},"labels":{"aa":"ORF1a: K3162E, P3504H; ORF1b: K134Q, T1064I, G1450R; S: L54F, P681H","spike_mutations":"L54F, P681H"}}},{"name":"B.1.1.354","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.354"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.354"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.894475221633911}},"branch_attrs":{"mutations":{"nuc":["A1T","G9389A","G28899T"],"N":["R209I"],"ORF1a":["D3042N"]},"labels":{"aa":"N: R209I; ORF1a: D3042N"}}},{"name":"B.1.1.46","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.46"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.46"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["A1C","C1218T","C27110T","T27384C"],"ORF1a":["S318L"]},"labels":{"aa":"ORF1a: S318L"}}}]},{"name":"NODE_0000616","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.25"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1366167068481445}},"branch_attrs":{"mutations":{"nuc":["A1G","A1163T"],"ORF1a":["I300F"]},"labels":{"aa":"ORF1a: I300F"}},"children":[{"name":"B.1.1.25","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.25"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.25"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1366167068481445}},"branch_attrs":{"mutations":{}}},{"name":"D.2","node_attrs":{"div":14,"clade_display":{"value":"20F"},"Nextclade_pango":{"value":"D.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20F"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.25.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20F"},"placement_prior":{"value":-3.0833330154418945}},"branch_attrs":{"mutations":{"nuc":["T7540C","G16647T","C18555T","G22992A","G23401A"],"S":["S477N"]},"labels":{"aa":"S: S477N","clade":"20F","spike_mutations":"S477N"}}},{"name":"NODE_0000617","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.315"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{"nuc":["G1A","T3256C","G14202T","C19718T","C22388T","C26060T","G29227T","C29466T","A29771G"],"N":["A398V"],"ORF1b":["E245D","T2084I"],"ORF3a":["T223I"]},"labels":{"aa":"N: A398V; ORF1b: E245D, T2084I; ORF3a: T223I"}},"children":[{"name":"AD.2","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.315.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.5890538692474365}},"branch_attrs":{"mutations":{"nuc":["C5622T","G19542T"],"ORF1a":["P1786L"],"ORF1b":["M2025I"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: M2025I"}}},{"name":"B.1.1.315","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.315"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.315"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000618","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.33"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8492207527160645}},"branch_attrs":{"mutations":{"nuc":["T27299C","T29148C"],"N":["I292T"],"ORF6":["I33T"]},"labels":{"aa":"N: I292T; ORF6: I33T"}},"children":[{"name":"B.1.1.33","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.33"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8492207527160645}},"branch_attrs":{"mutations":{}}},{"name":"N.3","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.3295159339904785}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"N.4","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.656519889831543}},"branch_attrs":{"mutations":{"nuc":["A1C","A2475G"],"ORF1a":["K737R"]},"labels":{"aa":"ORF1a: K737R"}}},{"name":"N.5","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A298G","C17274T","A22803G","C25904T","G29134A"],"ORF3a":["S171L"],"S":["Q414R"]},"labels":{"aa":"ORF3a: S171L; S: Q414R","spike_mutations":"Q414R"}}},{"name":"N.6","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.9203901290893555}},"branch_attrs":{"mutations":{"nuc":["C5365T","G8137T"]}}},{"name":"N.9","node_attrs":{"div":16,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.9"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["G1264T","C7600T","C7851T","T11078C","G23012A","A27853C","A29882C"],"ORF1a":["A2529V","F3605L"],"ORF7b":["E33A"],"S":["E484K"]},"labels":{"aa":"ORF1a: A2529V, F3605L; ORF7b: E33A; S: E484K","spike_mutations":"E484K"}}}]},{"name":"NODE_0000619","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.563066005706787}},"branch_attrs":{"mutations":{"nuc":["G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.1.523","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.523"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.523"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-16"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["A1087G","A1610G","A2311G","A2969G","G6609T","C9430T","G10961A","G11222T","C13356T","G14126A","C16466T","G16917A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22035-","A22036-","T22478C","T23042C","A23901C","A24078T","C24642T","C25904T","G25993T","A28273T","G28907T"],"N":["G212C"],"ORF1a":["N449D","M902V","R2115I","V3566I","V3653F","T4364I"],"ORF1b":["S220N","P1000L"],"ORF3a":["S171L","V201F"],"S":["E156-","F157-","R158-","F306L","S494P","E780A","D839V","T1027I"]},"labels":{"aa":"N: G212C; ORF1a: N449D, M902V, R2115I, V3566I, V3653F, T4364I; ORF1b: S220N, P1000L; ORF3a: S171L, V201F; S: E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I","spike_mutations":"E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I"}}},{"name":"NODE_0000620","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1T","C3961T","G7798T","C9072T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G20578A","C21846T","T21992-","A21993-","T21994-","T23287C","C23604A","G23948C","C25276A","A27887-","A27888-","C27889-","G27890-","A27891-","A27892-","C27893-","A27894-","T27895-","G27896-","A27897-","A27898-","A27899-","T27900-","T27901-","G28209T","A28271G","C28896-","T28897-","A28898-","C29769T"],"N":["A208-","R209G"],"ORF1a":["K2511N","T2936I","A3209V","S3675-","G3676-","F3677-"],"ORF1b":["V2371M"],"ORF8":["E106*"],"S":["T95I","Y144-","P681H","D796H"]},"labels":{"aa":"N: A208-, R209G; ORF1a: K2511N, T2936I, A3209V, S3675-, G3676-, F3677-; ORF1b: V2371M; ORF8: E106*; S: T95I, Y144-, P681H, D796H","spike_mutations":"T95I, Y144-, P681H, D796H"}},"children":[{"name":"AZ.4","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.4"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2416T","G7829C","T7831A","C17569T","T27384C"],"ORF1a":["V2522L"],"ORF1b":["P1368S"]},"labels":{"aa":"ORF1a: V2522L; ORF1b: P1368S"}}},{"name":"NODE_0000621","node_attrs":{"div":24,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C24382T"]}},"children":[{"name":"AZ.5","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.5"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T1G","G3259T","G6463T","T20994C","C29077T","A29879G"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"NODE_0000622","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.047728061676025}},"branch_attrs":{"mutations":{"nuc":["C10116T"],"ORF1a":["T3284I"]},"labels":{"aa":"ORF1a: T3284I"}},"children":[{"name":"B.1.1.318","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.047728061676025}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000623","node_attrs":{"div":27,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9889705181121826}},"branch_attrs":{"mutations":{"nuc":["A3852T","G21004T"],"ORF1a":["E1196V"],"ORF1b":["A2513S"]},"labels":{"aa":"ORF1a: E1196V; ORF1b: A2513S"}},"children":[{"name":"AZ.1","node_attrs":{"div":29,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.1"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.071262836456299}},"branch_attrs":{"mutations":{"nuc":["C11345T","C11644T"],"ORF1a":["L3694F"]},"labels":{"aa":"ORF1a: L3694F"}}},{"name":"AZ.2","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.2"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.056198596954346}},"branch_attrs":{"mutations":{"nuc":["C10369T","C12400T","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"AZ.3","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.3"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["T11850C"],"ORF1a":["M3862T"]},"labels":{"aa":"ORF1a: M3862T"}}}]}]}]}]}]},{"name":"NODE_0000624","node_attrs":{"div":28,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.706334114074707}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14676T","C15279T","T16176C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23271A","C23604A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","S3675-","G3676-","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["H69-","V70-","Y144-","N501Y","A570D","P681H","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, S3675-, G3676-, F3677-; ORF8: Q27*, R52I, Y73C; S: H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":28,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.706334114074707}},"branch_attrs":{"mutations":{}}},{"name":"Q.1","node_attrs":{"div":29,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.1"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-02"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.273845911026001}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}}},{"name":"Q.2","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.2"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-02"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.9566643238067627}},"branch_attrs":{"mutations":{"nuc":["A1752G","C6636T","G22468T","C25626T","C27752T","C28227T"],"ORF1a":["Y496C","T2124I"],"ORF7a":["T120I"],"ORF8":["H112Y"]},"labels":{"aa":"ORF1a: Y496C, T2124I; ORF7a: T120I; ORF8: H112Y"}}},{"name":"NODE_0000625","node_attrs":{"div":29,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.8349618911743164}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"Q.3","node_attrs":{"div":33,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.3"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-03"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.3964552879333496}},"branch_attrs":{"mutations":{"nuc":["G5023A","G10396T","G20962A","G26730C"],"M":["V70L"],"ORF1a":["M1586I"],"ORF1b":["D2499N"]},"labels":{"aa":"M: V70L; ORF1a: M1586I; ORF1b: D2499N"}}},{"name":"Q.4","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.4"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.756404399871826}},"branch_attrs":{"mutations":{"nuc":["C335T","A4964G","C7224T","A12162G","A23604G"],"ORF1a":["R24C","T1567A","A2320V","Q3966R"],"S":["H681R"]},"labels":{"aa":"ORF1a: R24C, T1567A, A2320V, Q3966R; S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000626","node_attrs":{"div":30,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.7612149715423584}},"branch_attrs":{"mutations":{"nuc":["T15096C","A28095T"],"ORF8":["K68*"]},"labels":{"aa":"ORF8: K68*"}},"children":[{"name":"Q.7","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.7"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-22"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.1349854469299316}},"branch_attrs":{"mutations":{"nuc":["A7069C","A17337G","T18018C","G28884C"],"N":["R204P"],"ORF1a":["E2268D"]},"labels":{"aa":"N: R204P; ORF1a: E2268D"}}},{"name":"Q.8","node_attrs":{"div":35,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.8"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-22"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-4.827495098114014}},"branch_attrs":{"mutations":{"nuc":["C12525T","C19164T","C25096T","A25974C","G29751T"],"ORF1a":["T4087I"],"ORF3a":["E194D"]},"labels":{"aa":"ORF1a: T4087I; ORF3a: E194D"}}}]}]},{"name":"NODE_0000627","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.3056695461273193}},"branch_attrs":{"mutations":{"nuc":["C313T"]}},"children":[{"name":"B.1.1.181","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.181"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.181"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.882154941558838}},"branch_attrs":{"mutations":{"nuc":["C14724T"]}}},{"name":"B.1.1.214","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.214"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.214"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-2.8961265087127686}},"branch_attrs":{"mutations":{"nuc":["C18167T","G21518T","G28975T"],"N":["M234I"],"ORF1b":["P1567L","R2684I"]},"labels":{"aa":"N: M234I; ORF1b: P1567L, R2684I"}}},{"name":"B.1.1.305","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.305"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.305"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.705223083496094}},"branch_attrs":{"mutations":{"nuc":["G28396A"],"ORF9b":["G38D"]},"labels":{"aa":"ORF9b: G38D"}}},{"name":"B.1.1.50","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.50"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.50"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.180130958557129}},"branch_attrs":{"mutations":{"nuc":["G4510A","G15438T","G25785T"],"ORF1b":["M657I"],"ORF3a":["W131C"]},"labels":{"aa":"ORF1b: M657I; ORF3a: W131C"}}},{"name":"B.1.1.51","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.51"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.51"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.485178470611572}},"branch_attrs":{"mutations":{"nuc":["T10453C","C11195T"],"ORF1a":["L3644F"]},"labels":{"aa":"ORF1a: L3644F"}}},{"name":"NODE_0000628","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.781398296356201}},"branch_attrs":{"mutations":{"nuc":["C9286T"]}},"children":[{"name":"B.1.1.284","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.284"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.284"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.229825973510742}},"branch_attrs":{"mutations":{"nuc":["T4346C","C10376T","C14708T","C28725T","G29692T"],"N":["P151L"],"ORF1a":["S1361P","P3371S"],"ORF1b":["A414V"]},"labels":{"aa":"N: P151L; ORF1a: S1361P, P3371S; ORF1b: A414V"}}},{"name":"B.1.1.47","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.47"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.47"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.771064281463623}},"branch_attrs":{"mutations":{"nuc":["C19763T"],"ORF1b":["T2099I"]},"labels":{"aa":"ORF1b: T2099I"}}}]},{"name":"NODE_0000629","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.306"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.095082759857178}},"branch_attrs":{"mutations":{"nuc":["A1C","C5700A"],"ORF1a":["A1812D"]},"labels":{"aa":"ORF1a: A1812D"}},"children":[{"name":"AE.8","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AE.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.943758726119995}},"branch_attrs":{"mutations":{"nuc":["C1347T","C1943T","C6031T","T7153C","G13975T"],"ORF1a":["P361L","R560C"],"ORF1b":["G170C"]},"labels":{"aa":"ORF1a: P361L, R560C; ORF1b: G170C"}}},{"name":"AE.1","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.027614116668701}},"branch_attrs":{"mutations":{"nuc":["C25791T"]}}},{"name":"B.1.1.306","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.306"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.095082759857178}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000630","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.462162494659424}},"branch_attrs":{"mutations":{"nuc":["T19839C"]}},"children":[{"name":"B.1.1.221","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.221"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.221"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.094874382019043}},"branch_attrs":{"mutations":{"nuc":["C21646T","C26846T"]}}},{"name":"B.1.1.220","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.220"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.220"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.653388977050781}},"branch_attrs":{"mutations":{"nuc":["C26681T"]}}},{"name":"B.1.1.291","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.291"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.291"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9558887481689453}},"branch_attrs":{"mutations":{"nuc":["C15933T","C29784T"]}}},{"name":"B.1.1.317","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.317"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.317"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8059520721435547}},"branch_attrs":{"mutations":{"nuc":["C28905T"],"N":["A211V"]},"labels":{"aa":"N: A211V"}}},{"name":"B.1.1.459","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.459"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.459"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.984232425689697}},"branch_attrs":{"mutations":{"nuc":["C16971T","A21137G","C24099T"],"ORF1b":["K2557R"],"S":["A846V"]},"labels":{"aa":"ORF1b: K2557R; S: A846V","spike_mutations":"A846V"}}},{"name":"B.1.1.464","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.464"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.464"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.0467987060546875}},"branch_attrs":{"mutations":{"nuc":["C12025T","C23707T"]}}},{"name":"B.1.1.521","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.521"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.521"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{"nuc":["C4927T","C9693T","C18744T","C23422T"],"ORF1a":["A3143V"]},"labels":{"aa":"ORF1a: A3143V"}}},{"name":"R.1","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"R.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.316.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.1175601482391357}},"branch_attrs":{"mutations":{"nuc":["C14340T","G17551A","C18877T","A19167G","C19274A","G22017T","G23012A","G23868T","T26604C","C27213T","C28833T","G29527T"],"M":["F28L"],"N":["S187L","Q418H"],"ORF1b":["G1362R","P1936H"],"S":["W152L","E484K","G769V"]},"labels":{"aa":"M: F28L; N: S187L, Q418H; ORF1b: G1362R, P1936H; S: W152L, E484K, G769V","spike_mutations":"W152L, E484K, G769V"}}},{"name":"NODE_0000631","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{"nuc":["A23756G"],"S":["T732A"]},"labels":{"aa":"S: T732A","spike_mutations":"T732A"}},"children":[{"name":"B.1.1.222","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.222"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.222"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000632","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.1.1.316","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.316"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.316"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.084819793701172}},"branch_attrs":{"mutations":{"nuc":["C21757T","G23593C","G23756T","G29751T"],"S":["Q677H","A732S"]},"labels":{"aa":"S: Q677H, A732S","spike_mutations":"Q677H, A732S"}}},{"name":"B.1.1.418","node_attrs":{"div":17,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.418"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.418"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["C1812T","A8072G","A10323G","A21194G","C22480T","G24197T","G24415T","G29751C"],"ORF1a":["A516V","N2603D","K3353R"],"ORF1b":["D2576G"],"S":["A879S"]},"labels":{"aa":"ORF1a: A516V, N2603D, K3353R; ORF1b: D2576G; S: A879S","spike_mutations":"A879S"}}}]}]}]},{"name":"NODE_0000633","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.308648586273193}},"branch_attrs":{"mutations":{"nuc":["G10097A","C23731T"],"ORF1a":["G3278S"]},"labels":{"aa":"ORF1a: G3278S"}},"children":[{"name":"B.1.1.369","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.369"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.369"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7873337268829346}},"branch_attrs":{"mutations":{"nuc":["G28580T"],"N":["D103Y"]},"labels":{"aa":"N: D103Y"}}},{"name":"B.1.1.372","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.372"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.372"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.308648586273193}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000634","node_attrs":{"div":12,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-3.7463936805725098}},"branch_attrs":{"mutations":{"nuc":["A1G","C4002T","C13536T"],"ORF1a":["T1246I"]},"labels":{"aa":"ORF1a: T1246I","clade":"20D"}},"children":[{"name":"B.1.1.1","node_attrs":{"div":12,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-3.7463936805725098}},"branch_attrs":{"mutations":{}}},{"name":"C.11","node_attrs":{"div":16,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.11"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.11"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["T3G","T8071C","G13201A","C27804T"]}}},{"name":"C.13","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.13"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.13"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.601921081542969}},"branch_attrs":{"mutations":{"nuc":["A21131G"],"ORF1b":["Q2555R"]},"labels":{"aa":"ORF1b: Q2555R"}}},{"name":"C.14","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.14"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.14"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.61112642288208}},"branch_attrs":{"mutations":{"nuc":["G29179T"]}}},{"name":"C.26","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.26"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.097334861755371}},"branch_attrs":{"mutations":{"nuc":["G1T","T8278C","G12661A","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-","A29866-","T29867-","G29868-","A29869-","C29870-","A29871-","A29872-","A29873-"]}}},{"name":"C.29","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.29"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.6840291023254395}},"branch_attrs":{"mutations":{"nuc":["T27900C"],"ORF8":["F3L"]},"labels":{"aa":"ORF8: F3L"}}},{"name":"C.23","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.23"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.90360689163208}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}}},{"name":"C.32","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.32"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.39810848236084}},"branch_attrs":{"mutations":{"nuc":["C14877T"]}}},{"name":"C.33","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.33"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.331234931945801}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}}},{"name":"C.35","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.0755510330200195}},"branch_attrs":{"mutations":{"nuc":["G1T","G5950T","G19732T"],"ORF1a":["K1895N"],"ORF1b":["V2089F"]},"labels":{"aa":"ORF1a: K1895N; ORF1b: V2089F"}}},{"name":"C.38","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.38"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-28"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A4307C","C4763T","C5812T","G6609T","A9103C","C9286T","A11201G","G11417T","C19862T","C21057T","C21727T","T21752A","G23012A","G23948T","T26112C","T26767C","C27925A","C28311T","C28905T","G29405C"],"M":["I82T"],"N":["P13L","A211V","E378Q"],"ORF1a":["K1348Q","H1500Y","R2115I","E2946D","T3646A","V3718F"],"ORF1b":["A2132V"],"ORF8":["T11K"],"ORF9b":["P10S"],"S":["W64R","E484K","D796Y"]},"labels":{"aa":"M: I82T; N: P13L, A211V, E378Q; ORF1a: K1348Q, H1500Y, R2115I, E2946D, T3646A, V3718F; ORF1b: A2132V; ORF8: T11K; ORF9b: P10S; S: W64R, E484K, D796Y","spike_mutations":"W64R, E484K, D796Y"}}},{"name":"C.4","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["A4G","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"NODE_0000635","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.439589977264404}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"C.16","node_attrs":{"div":16,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.2959184646606445}},"branch_attrs":{"mutations":{"nuc":["G3302A","C9693T","G29422T"],"ORF1a":["E1013K","A3143V"]},"labels":{"aa":"ORF1a: E1013K, A3143V"}}},{"name":"C.40","node_attrs":{"div":23,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"20D"},"qc.frameShifts.frameShifts":{"value":"S:245-246"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"S:245-246,ORF3a:258-276"},"partiallyAliased":{"value":"B.1.1.1.40"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-27"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2094T","A3069G","C9891T","A10982G","A12820G","C16466T","G22205C","T22292-","G22299-","A22300-","A22301-","G22302-","T22303-","C23481T","C24138A","A26161-","A28271-","G28917T"],"N":["G215V"],"ORF1a":["S610L","D935G","A3209V","K3573E"],"ORF1b":["P1000L"],"ORF3a":["N257-"],"S":["D215H","L244-","S247-","S640F","T859N"]},"labels":{"aa":"N: G215V; ORF1a: S610L, D935G, A3209V, K3573E; ORF1b: P1000L; ORF3a: N257-; S: D215H, L244-, S247-, S640F, T859N","spike_mutations":"D215H, L244-, S247-, S640F, T859N"}}}]},{"name":"NODE_0000636","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.998632907867432}},"branch_attrs":{"mutations":{"nuc":["T14345C","G18292T"],"ORF1b":["L293S","A1609S"]},"labels":{"aa":"ORF1b: L293S, A1609S"}},"children":[{"name":"C.2","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.998632907867432}},"branch_attrs":{"mutations":{}}},{"name":"C.2.1","node_attrs":{"div":22,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.2.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["G922T","T8323C","T15437C","C18501T","A23064C","C25624T","C28453T","C29642T"],"ORF1b":["M657T"],"ORF3a":["H78Y"],"ORF9b":["A57V"],"S":["N501T"]},"labels":{"aa":"ORF1b: M657T; ORF3a: H78Y; ORF9b: A57V; S: N501T","spike_mutations":"N501T"}}}]},{"name":"NODE_0000637","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.791934013366699}},"branch_attrs":{"mutations":{"nuc":["C18747T","G29425T"],"N":["Q384H"]},"labels":{"aa":"N: Q384H"}},"children":[{"name":"B.1.1.375","node_attrs":{"div":23,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.375"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.375"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.2221879959106445}},"branch_attrs":{"mutations":{"nuc":["G1A","C2509T","T4002C","C6781T","A10097G","G17027T","G22992A","A23233G","G28048A"],"ORF1a":["I1246T","S3278G"],"ORF1b":["S1187I"],"ORF8":["R52K"],"S":["S477N"]},"labels":{"aa":"ORF1a: I1246T, S3278G; ORF1b: S1187I; ORF8: R52K; S: S477N","spike_mutations":"S477N"}}},{"name":"C.1","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.791934013366699}},"branch_attrs":{"mutations":{}}},{"name":"C.1.2","node_attrs":{"div":30,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.1.2"},"totalAminoacidDeletions":{"value":5},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["G569A","C2485T","C5175T","A7699G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21969T","G22132T","A22206G","C22210T","G22289-","C22290-","T22291-","T22907C","G23012A","A23063T","C23525T","T23599A","C23709T","G26155-","T26156-","T26157-","C28311T","T28516C"],"N":["P13L"],"ORF1a":["E102K","T1637I","S3675-","G3676-","F3677-"],"ORF3a":["V255-"],"ORF9b":["P10S","M78T"],"S":["C136F","R190S","D215G","A243-","Y449H","E484K","N501Y","H655Y","N679K","T716I"]},"labels":{"aa":"N: P13L; ORF1a: E102K, T1637I, S3675-, G3676-, F3677-; ORF3a: V255-; ORF9b: P10S, M78T; S: C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I","spike_mutations":"C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I"}}}]},{"name":"NODE_0000638","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.54981803894043}},"branch_attrs":{"mutations":{"nuc":["G28908T"],"N":["G212V"]},"labels":{"aa":"N: G212V"}},"children":[{"name":"C.36","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.54981803894043}},"branch_attrs":{"mutations":{}}},{"name":"internal_9cca","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G569A","C2841T","G5180A","C7124T","G9203A","G9929A","C11325T","T11337C","C12534T","G16549T","C17766T","C21597T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22016A","A22600C","T22917G","G23593T","G24257T","T26767C","G27882T","A28271-"],"M":["I82T"],"ORF1a":["E102K","A859V","D1639N","P2287S","D2980N","D3222N","S3687L","L3691S","T4090I"],"ORF1b":["D1028Y"],"ORF7b":["A43S"],"S":["S12F","H69-","V70-","W152R","R346S","L452R","Q677H","A899S"]},"labels":{"aa":"M: I82T; ORF1a: E102K, A859V, D1639N, P2287S, D2980N, D3222N, S3687L, L3691S, T4090I; ORF1b: D1028Y; ORF7b: A43S; S: S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S","spike_mutations":"S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S"}},"children":[{"name":"C.36.3.1","node_attrs":{"div":40,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36.3.1"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-26"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C6706T","C17822T","C18189T","G22992A","T24811C","T25729C","A29040G","C29632T"],"N":["K256R"],"ORF1b":["P1452L"],"ORF3a":["Y113H"],"S":["S477N"]},"labels":{"aa":"N: K256R; ORF1b: P1452L; ORF3a: Y113H; S: S477N","spike_mutations":"S477N"}}},{"name":"C.36.3","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36.3"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-26"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000640","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9867C","T22917A","C28253T","A28271C"],"ORF1a":["L3201P"],"S":["L452Q"]},"labels":{"aa":"ORF1a: L3201P; S: L452Q","spike_mutations":"L452Q"}},"children":[{"name":"C.39","node_attrs":{"div":31,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2110T","C4763T","C6726T","C7113T","T7348G","C11345T","C14585T","C15194A","C21588T","G22131A","C22997T","T26038C","C26366T","C27128T","A28742G"],"E":["A41V"],"N":["I157V"],"ORF1a":["H1500Y","T2154I","T2283I","N2361K","L3694F"],"ORF1b":["A373V","A576D"],"ORF3a":["S216P"],"S":["P9L","R190K","P479S"]},"labels":{"aa":"E: A41V; N: I157V; ORF1a: H1500Y, T2154I, T2283I, N2361K, L3694F; ORF1b: A373V, A576D; ORF3a: S216P; S: P9L, R190K, P479S","spike_mutations":"P9L, R190K, P479S"}}},{"name":"NODE_0000641","node_attrs":{"div":28,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37"},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{"nuc":["C7124T","T7424G","C9857T","C10029T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21786T","C21789T","G22299-","A22300-","A22301-","G22302-","T22303-","T22304-","A22305-","T22306-","T22307-","T22308-","G22309-","A22310-","C22311-","T22312-","C22313-","C22314-","T22315-","G22316-","G22317-","T22318-","G22319-","T23031C","C24138A","C26894T","C28271T","C28311T","G28913T","C29311T"],"N":["P13L","G214C"],"ORF1a":["P2287S","F2387V","T3255I","S3675-","G3676-","F3677-"],"ORF9b":["P10S"],"S":["G75V","T76I","R246-","S247-","Y248-","L249-","T250-","P251-","G252-","D253N","F490S","T859N"]},"labels":{"aa":"N: P13L, G214C; ORF1a: P2287S, F2387V, T3255I, S3675-, G3676-, F3677-; ORF9b: P10S; S: G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N","clade":"Lambda","spike_mutations":"G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N"}},"children":[{"name":"C.37","node_attrs":{"div":28,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.37"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-23"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{}}},{"name":"C.37.1","node_attrs":{"div":32,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.37.1"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C20806T","T25760C","A28877T","G28878C"],"ORF3a":["I123T"]},"labels":{"aa":"ORF3a: I123T"}}}]}]}]}]},{"name":"NODE_0000642","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8542699813842773}},"branch_attrs":{"mutations":{"nuc":["G25088T"],"S":["V1176F"]},"labels":{"aa":"S: V1176F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.28","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8542699813842773}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.332","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.332"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.332"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.391775608062744}},"branch_attrs":{"mutations":{"nuc":["A1G","C442A","C6310T","G11417T","C12053T","T16944C","G26062C"],"ORF1a":["V3718F","L3930F"],"ORF3a":["G224R"]},"labels":{"aa":"ORF1a: V3718F, L3930F; ORF3a: G224R"}}},{"name":"P.3","node_attrs":{"div":26,"clade_display":{"value":"21E (Theta)"},"Nextclade_pango":{"value":"P.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21E"},"clade_who":{"value":"Theta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-10"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"21E"},"placement_prior":{"value":-4.444321632385254}},"branch_attrs":{"mutations":{"nuc":["A4926G","C7564A","T9867C","C11308A","C12049T","C12053T","C17074T","C17339T","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","A22356G","G23012A","A23063T","T23341C","C23604A","T24187A","G24836A","C24863T","A27897C","A28271-","C29724T"],"ORF1a":["D1554G","L3201P","D3681E","L3930F"],"ORF1b":["L1203F","A1291V"],"ORF8":["K2Q"],"S":["L141-","G142-","V143-","Y265C","E484K","N501Y","P681H","E1092K","H1101Y"]},"labels":{"aa":"ORF1a: D1554G, L3201P, D3681E, L3930F; ORF1b: L1203F, A1291V; ORF8: K2Q; S: L141-, G142-, V143-, Y265C, E484K, N501Y, P681H, E1092K, H1101Y","clade":"Theta","spike_mutations":"L141-, G142-, V143-, Y265C, E484K, N501Y, P681H, E1092K, H1101Y"}}},{"name":"P.7","node_attrs":{"div":21,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.7"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A1G","C1288T","C7124T","C7765T","G8027T","C9344T","G10870T","G11596T","C12053T","C17172T","C17676T","C25844T","C28311T"],"N":["P13L"],"ORF1a":["P2287S","V2588F","L3027F","Q3777H","L3930F"],"ORF3a":["T151I"],"ORF9b":["P10S"]},"labels":{"aa":"N: P13L; ORF1a: P2287S, V2588F, L3027F, Q3777H, L3930F; ORF3a: T151I; ORF9b: P10S"}}},{"name":"NODE_0000643","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.082197666168213}},"branch_attrs":{"mutations":{"nuc":["C12053T","C28253T"],"ORF1a":["L3930F"]},"labels":{"aa":"ORF1a: L3930F"}},"children":[{"name":"P.2","node_attrs":{"div":17,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.3414323329925537}},"branch_attrs":{"mutations":{"nuc":["C100T","T10667G","C11824T","G23012A","G28628T","G28975T","C29754T"],"N":["A119S","M234I"],"ORF1a":["L3468V"],"S":["E484K"]},"labels":{"aa":"N: A119S, M234I; ORF1a: L3468V; S: E484K","spike_mutations":"E484K"}}},{"name":"P.6","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-27"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C1077T","G2534T","C3736T","C7043T","C8980T","C10029T","A14113G","G21305A","G23587C","G23593T","C24382T","C25665T","G26172T"],"ORF1a":["P271L","V757F","P2260S","T3255I"],"ORF1b":["T216A","R2613H"],"ORF3a":["M260I"],"S":["Q675H","Q677H"]},"labels":{"aa":"ORF1a: P271L, V757F, P2260S, T3255I; ORF1b: T216A, R2613H; ORF3a: M260I; S: Q675H, Q677H","spike_mutations":"Q675H, Q677H"}}}]},{"name":"NODE_0000644","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-6.34883975982666}},"branch_attrs":{"mutations":{"nuc":["C11450A","A28271C"],"ORF1a":["Q3729K"]},"labels":{"aa":"ORF1a: Q3729K"}},"children":[{"name":"P.4","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-25"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A136G","G1811A","C3177T","C9693T","T9867C","C12008T","C12880T","A15932G","G18756T","C20436T","T22054G","C22079A","T22917G","C23673T","A23720G","G25540A","C28253T","C28932T"],"N":["A220V"],"ORF1a":["A516T","P971L","A3143V","L3201P","L3915F"],"ORF1b":["Y822C"],"ORF3a":["V50I"],"S":["N164K","Q173K","L452R","S704L","I720V"]},"labels":{"aa":"N: A220V; ORF1a: A516T, P971L, A3143V, L3201P, L3915F; ORF1b: Y822C; ORF3a: V50I; S: N164K, Q173K, L452R, S704L, I720V","spike_mutations":"N164K, Q173K, L452R, S704L, I720V"}}},{"name":"P.5","node_attrs":{"div":27,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-19"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5175T","C8950T","C9891T","T10264C","C11152T","C13275T","T14103C","C14571T","T21568A","C21602A","C21721T","C21846T","G23012C","A23064C","C24904T","C28271T","C28531T","G28917T"],"N":["G215V"],"ORF1a":["T1637I","A3209V","P4337L"],"ORF9b":["T83I"],"S":["F2L","Q14K","T95I","E484Q","N501T"]},"labels":{"aa":"N: G215V; ORF1a: T1637I, A3209V, P4337L; ORF9b: T83I; S: F2L, Q14K, T95I, E484Q, N501T","spike_mutations":"F2L, Q14K, T95I, E484Q, N501T"}}}]},{"name":"NODE_0000645","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.67503023147583}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21974T","A28877T","G28878C"],"ORF1a":["S3675-","G3676-","F3677-"],"S":["D138Y"]},"labels":{"aa":"ORF1a: S3675-, G3676-, F3677-; S: D138Y","spike_mutations":"D138Y"}},"children":[{"name":"B.1.1.528","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.528"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.528"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-19"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["A1072G","C1449T","C2094T","A3868T","G9526T","G9756A","G16853T","T22912G","C23604G","T25088G","T26767C","C27297T","A28911T","C29303T"],"M":["I82T"],"N":["N213I","P344S"],"ORF1a":["T395I","S610L","Q1201H","M3087I","R3164H"],"ORF1b":["G1129V"],"S":["N450K","P681R","F1176V"]},"labels":{"aa":"M: I82T; N: N213I, P344S; ORF1a: T395I, S610L, Q1201H, M3087I, R3164H; ORF1b: G1129V; S: N450K, P681R, F1176V","spike_mutations":"N450K, P681R, F1176V"}}},{"name":"NODE_0000646","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{"nuc":["T733C","C2749T","C3828T","A5648C","A6319G","A6613G","C12778T","C13860T","G17259T","C21614T","C21621A","C21638T","G22132T","A22812C","G23012A","A23063T","C23525T","C24642T","T26149C","G28167A","C28512G","T29834A"],"N":["P80R"],"ORF1a":["S1188L","K1795Q"],"ORF1b":["E1264D"],"ORF3a":["S253P"],"ORF8":["E92K"],"ORF9b":["Q77E"],"S":["L18F","T20N","P26S","R190S","K417T","E484K","N501Y","H655Y","T1027I"]},"labels":{"aa":"N: P80R; ORF1a: S1188L, K1795Q; ORF1b: E1264D; ORF3a: S253P; ORF8: E92K; ORF9b: Q77E; S: L18F, T20N, P26S, R190S, K417T, E484K, N501Y, H655Y, T1027I","clade":"Gamma","spike_mutations":"L18F, T20N, P26S, R190S, K417T, E484K, N501Y, H655Y, T1027I"}},"children":[{"name":"P.1","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{}}},{"name":"P.1.1","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-08"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.7353131771087646}},"branch_attrs":{"mutations":{"nuc":["T13851C"]}}},{"name":"P.1.11","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.11"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.509119987487793}},"branch_attrs":{"mutations":{"nuc":["C7945T","C23604G"],"S":["P681R"]},"labels":{"aa":"S: P681R","spike_mutations":"P681R"}}},{"name":"P.1.12","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.12"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-23"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{}}},{"name":"P.1.12.1","node_attrs":{"div":43,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.12.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-19"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["T3592C","T14769G","G20925A","A22298G","C22413T","T23599A","C25613T","C25844T","T28251G","C28253T"],"ORF3a":["S74F","T151I"],"ORF8":["F120V"],"S":["R246G","T284I","N679K"]},"labels":{"aa":"ORF3a: S74F, T151I; ORF8: F120V; S: R246G, T284I, N679K","spike_mutations":"R246G, T284I, N679K"}}},{"name":"P.1.14","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.14"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8808484077453613}},"branch_attrs":{"mutations":{"nuc":["A1G","G9105A","C23380T"],"ORF1a":["S2947N"]},"labels":{"aa":"ORF1a: S2947N"}}},{"name":"P.1.15","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.15"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.483485460281372}},"branch_attrs":{"mutations":{"nuc":["A2596G","C18129T"]}}},{"name":"P.1.16","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.16"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.7957029342651367}},"branch_attrs":{"mutations":{"nuc":["A25746G"],"ORF3a":["I118M"]},"labels":{"aa":"ORF3a: I118M"}}},{"name":"P.1.4","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.4"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.011761665344238}},"branch_attrs":{"mutations":{"nuc":["T23599G"],"S":["N679K"]},"labels":{"aa":"S: N679K","spike_mutations":"N679K"}}},{"name":"P.1.6","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.6"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10615T","C15714T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}},{"name":"P.1.7.1","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.7.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T3049C","C10116T","C23604A"],"ORF1a":["T3284I"],"S":["P681H"]},"labels":{"aa":"ORF1a: T3284I; S: P681H","spike_mutations":"P681H"}}},{"name":"NODE_0000647","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.013174533843994}},"branch_attrs":{"mutations":{"nuc":["A1T","C1427T"],"ORF1a":["H388Y"]},"labels":{"aa":"ORF1a: H388Y"}},"children":[{"name":"P.1.10","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.10"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-12"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.013174533843994}},"branch_attrs":{"mutations":{}}},{"name":"P.1.10.1","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.10.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-12"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.112314701080322}},"branch_attrs":{"mutations":{"nuc":["C2841T","G4300T","C13329T","C26873T"],"ORF1a":["A859V","T4355I"]},"labels":{"aa":"ORF1a: A859V, T4355I"}}}]},{"name":"NODE_0000648","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A1T","C346T","C28603T"]}},"children":[{"name":"P.1.17.1","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.17.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A6704G","G19999T","C21707T"],"ORF1a":["N2147D"],"ORF1b":["V2178F"],"S":["H49Y"]},"labels":{"aa":"ORF1a: N2147D; ORF1b: V2178F; S: H49Y","spike_mutations":"H49Y"}}},{"name":"P.1.17","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.17"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000649","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["T592C","A4040G","C9891T"],"ORF1a":["I1259V","A3209V"]},"labels":{"aa":"ORF1a: I1259V, A3209V"}},"children":[{"name":"P.1.8","node_attrs":{"div":42,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.8"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-03"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A20055G","C22971A","C23604G","G25266T","C26039T","G27915T"],"ORF3a":["S216L"],"ORF8":["G8*"],"S":["T470N","P681R","C1235F"]},"labels":{"aa":"ORF3a: S216L; ORF8: G8*; S: T470N, P681R, C1235F","spike_mutations":"T470N, P681R, C1235F"}}},{"name":"P.1.9","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.9"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C6040T","C18647T","G23587C"],"ORF1b":["P1727L"],"S":["Q675H"]},"labels":{"aa":"ORF1b: P1727L; S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000650","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.685761451721191}},"branch_attrs":{"mutations":{"nuc":["C1912T"]}},"children":[{"name":"P.1.13","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.13"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.1822357177734375}},"branch_attrs":{"mutations":{"nuc":["G10610T"],"ORF1a":["V3449F"]},"labels":{"aa":"ORF1a: V3449F"}}},{"name":"P.1.2","node_attrs":{"div":38,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.2"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-26"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.205961227416992}},"branch_attrs":{"mutations":{"nuc":["A2550G","C5724T","G25855T","C28789T"],"ORF1a":["D762G","T1820I"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF1a: D762G, T1820I; ORF3a: D155Y"}}},{"name":"P.1.7","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.7"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.55728816986084}},"branch_attrs":{"mutations":{"nuc":["C16293T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}}]}]}]}]},{"name":"NODE_0000651","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7765681743621826}},"branch_attrs":{"mutations":{"nuc":["C10029T","C22995A","C23604A"],"ORF1a":["T3255I"],"S":["T478K","P681H"]},"labels":{"aa":"ORF1a: T3255I; S: T478K, P681H","spike_mutations":"T478K, P681H"}},"children":[{"name":"B.1.1.519","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.519"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.519"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-2.7773401737213135}},"branch_attrs":{"mutations":{"nuc":["C203T","C222T","C3140T","C10954T","A11117G","C12789T","T19839C","C21306T","A23756G","C29197T"],"ORF1a":["P959S","I3618V","T4175I"],"S":["T732A"]},"labels":{"aa":"ORF1a: P959S, I3618V, T4175I; S: T732A","spike_mutations":"T732A"}}},{"name":"21M","node_attrs":{"div":40,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-3.6954684257507324}},"branch_attrs":{"mutations":{"nuc":["C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","A23013C","A23040G","A23055G","A23063T","T23075C","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C26270T","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-"],"ORF1a":["P3395H","S3675-","G3676-"],"ORF1b":["I1566V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371F","S373P","S375F","K417N","N440K","G446S","S477N","E484A","Q493R","Q498R","N501Y","Y505H","H655Y","N679K","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-; ORF1a: P3395H, S3675-, G3676-; ORF1b: I1566V; ORF9b: P10S, E27-, N28-, A29-; S: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K","clade":"Omicron","spike_mutations":"A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"NODE_0000653","node_attrs":{"div":54,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.9919633865356445}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","clade":"21K","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}},"children":[{"name":"BA.1","node_attrs":{"div":54,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":46},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.9919633865356445}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.12","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.12"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7732186317443848}},"branch_attrs":{"mutations":{"nuc":["A5T","G22487C","C28315T"],"ORF9b":["A11V"],"S":["E309Q"]},"labels":{"aa":"ORF9b: A11V; S: E309Q","spike_mutations":"E309Q"}}},{"name":"BA.1.10","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.10"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.681899070739746}},"branch_attrs":{"mutations":{"nuc":["C21T","A17042G"],"ORF1b":["Y1192C"]},"labels":{"aa":"ORF1b: Y1192C"}}},{"name":"BA.1.19","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.19"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.5513505935668945}},"branch_attrs":{"mutations":{"nuc":["A1G","C21034T"],"ORF1b":["L2523F"]},"labels":{"aa":"ORF1b: L2523F"}}},{"name":"BA.1.18","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.18"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.3796181678771973}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}}},{"name":"BA.1.2","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.660147190093994}},"branch_attrs":{"mutations":{"nuc":["C7420T","C11669T"],"ORF1a":["R3802C"]},"labels":{"aa":"ORF1a: R3802C"}}},{"name":"BA.1.20","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.20"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.5852789878845215}},"branch_attrs":{"mutations":{"nuc":["C11950T","C28472T"],"N":["P67S"]},"labels":{"aa":"N: P67S"}}},{"name":"BA.1.22","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.22"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.776266574859619}},"branch_attrs":{"mutations":{"nuc":["C21T","G3182A","G5515T"],"ORF1a":["E973K"]},"labels":{"aa":"ORF1a: E973K"}}},{"name":"BA.1.23","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.23"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.952954292297363}},"branch_attrs":{"mutations":{"nuc":["G22599C","T22926G","A22935T","C23013T","C23625T"],"S":["R346T","L455W","K458M","A484V","A688V"]},"labels":{"aa":"S: R346T, L455W, K458M, A484V, A688V","spike_mutations":"R346T, L455W, K458M, A484V, A688V"}}},{"name":"BA.1.3","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.336390495300293}},"branch_attrs":{"mutations":{"nuc":["C21T","A3481G","C8645T"],"ORF1a":["H2794Y"]},"labels":{"aa":"ORF1a: H2794Y"}}},{"name":"BA.1.24","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.24"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.808385372161865}},"branch_attrs":{"mutations":{"nuc":["G22580A","G28378T"],"ORF9b":["R32L"],"S":["E340K"]},"labels":{"aa":"ORF9b: R32L; S: E340K","spike_mutations":"E340K"}}},{"name":"BA.1.6","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.6"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.269890308380127}},"branch_attrs":{"mutations":{"nuc":["C21T","C17639T"],"ORF1b":["S1391L"]},"labels":{"aa":"ORF1b: S1391L"}}},{"name":"BA.1.4","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.4"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.153940677642822}},"branch_attrs":{"mutations":{"nuc":["C21T","G23351A"],"S":["V597I"]},"labels":{"aa":"S: V597I","spike_mutations":"V597I"}}},{"name":"BA.1.5","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.5"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.170540809631348}},"branch_attrs":{"mutations":{"nuc":["C21T","C2091T","C24054T"],"ORF1a":["T609I"],"S":["A831V"]},"labels":{"aa":"ORF1a: T609I; S: A831V","spike_mutations":"A831V"}}},{"name":"BA.1.9","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.9"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.14980149269104}},"branch_attrs":{"mutations":{"nuc":["A1C","C21T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BA.1.7","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.7"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.598451852798462}},"branch_attrs":{"mutations":{"nuc":["C21T","C27686T"],"ORF7a":["S98F"]},"labels":{"aa":"ORF7a: S98F"}}},{"name":"BA.1.8","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.8"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.060263156890869}},"branch_attrs":{"mutations":{"nuc":["A1G","C11455T","C23987T","C29666T"],"S":["P809S"]},"labels":{"aa":"S: P809S","spike_mutations":"P809S"}}},{"name":"NODE_0000654","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{"nuc":["G1957T"],"ORF1a":["K564N"]},"labels":{"aa":"ORF1a: K564N"}},"children":[{"name":"BA.1.13","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.13"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.13.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.13.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.6200735569000244}},"branch_attrs":{"mutations":{"nuc":["A3779G","G19684T"],"ORF1a":["N1172D"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1a: N1172D; ORF1b: V2073L"}}}]},{"name":"NODE_0000655","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4473202228546143}},"branch_attrs":{"mutations":{"nuc":["G27762T"],"ORF7b":["E3*"]},"labels":{"aa":"ORF7b: E3*"}},"children":[{"name":"BA.1.21","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.21"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4473202228546143}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.21.1","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.21.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.046947002410889}},"branch_attrs":{"mutations":{"nuc":["T15685A"],"ORF1b":["L740M"]},"labels":{"aa":"ORF1b: L740M"}}}]},{"name":"NODE_0000656","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{"nuc":["A1C","C12786T"],"ORF1a":["T4174I"]},"labels":{"aa":"ORF1a: T4174I"}},"children":[{"name":"BA.1.14","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.14.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.468590497970581}},"branch_attrs":{"mutations":{"nuc":["C11109T"],"ORF1a":["A3615V"]},"labels":{"aa":"ORF1a: A3615V"}}},{"name":"BA.1.14.2","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.215561389923096}},"branch_attrs":{"mutations":{"nuc":["C1812T"],"ORF1a":["A516V"]},"labels":{"aa":"ORF1a: A516V"}}}]},{"name":"NODE_0000657","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{"nuc":["T3104C","C29632T"],"ORF1a":["Y947H"]},"labels":{"aa":"ORF1a: Y947H"}},"children":[{"name":"BA.1.16","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.16.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.663555145263672}},"branch_attrs":{"mutations":{"nuc":["G9758A","G25455A","T25556G"],"ORF1a":["V3165I"],"ORF3a":["V55G"]},"labels":{"aa":"ORF1a: V3165I; ORF3a: V55G"}}},{"name":"BA.1.16.2","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-5.067101955413818}},"branch_attrs":{"mutations":{"nuc":["C21T","T12436C","A28254G"],"ORF8":["I121V"]},"labels":{"aa":"ORF8: I121V"}}}]},{"name":"NODE_0000658","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{"nuc":["A1C","T10135C","C25708T","A29301G"],"N":["D343G"],"ORF3a":["L106F"]},"labels":{"aa":"N: D343G; ORF3a: L106F"}},"children":[{"name":"BA.1.15.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.538003921508789}},"branch_attrs":{"mutations":{"nuc":["A24803G"],"S":["I1081V"]},"labels":{"aa":"S: I1081V","spike_mutations":"I1081V"}}},{"name":"BA.1.15","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.15.3","node_attrs":{"div":61,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.2535817623138428}},"branch_attrs":{"mutations":{"nuc":["C21T","C3602T","C25886T"],"ORF1a":["H1113Y"],"ORF3a":["S165F"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: S165F"}}},{"name":"BA.1.15.2","node_attrs":{"div":60,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.754347085952759}},"branch_attrs":{"mutations":{"nuc":["G22520A","C23444A"],"S":["V320I","Q628K"]},"labels":{"aa":"S: V320I, Q628K","spike_mutations":"V320I, Q628K"}}}]},{"name":"NODE_0000659","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{"nuc":["A1C","G5924A"],"ORF1a":["V1887I"]},"labels":{"aa":"ORF1a: V1887I"}},"children":[{"name":"BA.1.17","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.17.1","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.100674629211426}},"branch_attrs":{"mutations":{"nuc":["C21T","C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}}},{"name":"NODE_0000660","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.2"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.335338592529297}},"branch_attrs":{"mutations":{"nuc":["C1G","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}},"children":[{"name":"BA.1.17.2","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.335338592529297}},"branch_attrs":{"mutations":{}}},{"name":"BD.1","node_attrs":{"div":61,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.2.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4503445625305176}},"branch_attrs":{"mutations":{"nuc":["C21T","C3241T","C23444A"],"S":["Q628K"]},"labels":{"aa":"S: Q628K","spike_mutations":"Q628K"}}}]}]},{"name":"NODE_0000661","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4241011142730713}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}},"children":[{"name":"BA.1.1","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-07"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4241011142730713}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.1.3","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["C4582T","C23934T","A28416G"],"N":["N48S"],"ORF9b":["I45V"],"S":["T791I"]},"labels":{"aa":"N: N48S; ORF9b: I45V; S: T791I","spike_mutations":"T791I"}}},{"name":"BA.1.1.4","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.4"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7377076148986816}},"branch_attrs":{"mutations":{"nuc":["C21T","G16744A","T25711C","C29754T"],"ORF1b":["G1093S"],"ORF3a":["Y107H"]},"labels":{"aa":"ORF1b: G1093S; ORF3a: Y107H"}}},{"name":"NODE_0000662","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.674670696258545}},"branch_attrs":{"mutations":{"nuc":["A1T","A16064G"],"ORF1b":["Q866R"]},"labels":{"aa":"ORF1b: Q866R"}},"children":[{"name":"BA.1.1.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.674670696258545}},"branch_attrs":{"mutations":{}}},{"name":"BC.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.36091685295105}},"branch_attrs":{"mutations":{"nuc":["C5833T","A22259G"],"S":["I233V"]},"labels":{"aa":"S: I233V","spike_mutations":"I233V"}}},{"name":"BC.2","node_attrs":{"div":60,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.884258270263672}},"branch_attrs":{"mutations":{"nuc":["C21T","C13862T","G19348A"],"ORF1b":["T132I","V1961I"]},"labels":{"aa":"ORF1b: T132I, V1961I"}}}]},{"name":"NODE_0000663","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.3621480464935303}},"branch_attrs":{"mutations":{"nuc":["C2470T"]}},"children":[{"name":"BA.1.1.11","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.11"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.2315807342529297}},"branch_attrs":{"mutations":{"nuc":["G2354A"],"ORF1a":["G697R"]},"labels":{"aa":"ORF1a: G697R"}}},{"name":"BA.1.1.10","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.10"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4704771041870117}},"branch_attrs":{"mutations":{"nuc":["C21T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"BA.1.1.12","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.12"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.3868720531463623}},"branch_attrs":{"mutations":{"nuc":["C21T","C2942A"],"ORF1a":["L893M"]},"labels":{"aa":"ORF1a: L893M"}}},{"name":"BA.1.1.13","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.13"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.139563798904419}},"branch_attrs":{"mutations":{"nuc":["C21T","C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"BA.1.1.14","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.14"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.8932130336761475}},"branch_attrs":{"mutations":{"nuc":["A14107G"],"ORF1b":["I214V"]},"labels":{"aa":"ORF1b: I214V"}}},{"name":"BA.1.1.16","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.16"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.8349038362503052}},"branch_attrs":{"mutations":{"nuc":["A1C","C21595T","C27509G"],"ORF7a":["T39R"]},"labels":{"aa":"ORF7a: T39R"}}},{"name":"BA.1.1.17","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.17"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.2085862159729}},"branch_attrs":{"mutations":{"nuc":["G1659T","C5183T"],"ORF1a":["G465V","P1640S"]},"labels":{"aa":"ORF1a: G465V, P1640S"}}},{"name":"BA.1.1.15","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.15"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.933518171310425}},"branch_attrs":{"mutations":{"nuc":["G13570A","G29755C"],"ORF1b":["G35S"]},"labels":{"aa":"ORF1b: G35S"}}},{"name":"BA.1.1.18","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.18"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.329127073287964}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"ORF1a":["A2554V"]},"labels":{"aa":"ORF1a: A2554V"}}},{"name":"BA.1.1.2","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.413982391357422}},"branch_attrs":{"mutations":{"nuc":["C10560G"],"ORF1a":["T3432S"]},"labels":{"aa":"ORF1a: T3432S"}}},{"name":"BA.1.1.5","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.5"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.915313482284546}},"branch_attrs":{"mutations":{"nuc":["C21T","A2589G","C26996T"],"ORF1a":["E775G"]},"labels":{"aa":"ORF1a: E775G"}}},{"name":"BA.1.1.7","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.7"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.486417531967163}},"branch_attrs":{"mutations":{"nuc":["C2453T"],"ORF1a":["L730F"]},"labels":{"aa":"ORF1a: L730F"}}},{"name":"BA.1.1.8","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.8"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.9190704822540283}},"branch_attrs":{"mutations":{"nuc":["C1766A"],"ORF1a":["Q501K"]},"labels":{"aa":"ORF1a: Q501K"}}},{"name":"BA.1.1.9","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.9"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4197943210601807}},"branch_attrs":{"mutations":{"nuc":["C13421T"],"ORF1a":["L4386F"]},"labels":{"aa":"ORF1a: L4386F"}}},{"name":"BA.1.1.6","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.6"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.071193695068359}},"branch_attrs":{"mutations":{"nuc":["C21T","C5144T","C28757T"],"N":["P162S"]},"labels":{"aa":"N: P162S"}}}]}]}]},{"name":"internal_a01b","node_attrs":{"div":51,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.757229804992676}},"branch_attrs":{"mutations":{"nuc":["T670G","G4184A","C4321T","C9534T","G10447A","T11294-","T11295-","T11296-","C12880T","C15714T","G22775A","C26060T","C26858T","A29510C","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["S413R"],"ORF1a":["S135R","G1307S","T3090I","F3677-"],"ORF3a":["T223I"],"S":["D405N"]},"labels":{"aa":"N: S413R; ORF1a: S135R, G1307S, T3090I, F3677-; ORF3a: T223I; S: D405N","spike_mutations":"D405N"}},"children":[{"name":"internal_8b65","node_attrs":{"div":54,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}},"children":[{"name":"BA.3.1","node_attrs":{"div":57,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3.1"},"totalAminoacidDeletions":{"value":15},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-21"},"totalAminoacidSubstitutions":{"value":45},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3791A","C3792A","A22812C"],"ORF1a":["A1176N"],"S":["N417T"]},"labels":{"aa":"ORF1a: A1176N; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.3","node_attrs":{"div":54,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3"},"totalAminoacidDeletions":{"value":15},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-14"},"totalAminoacidSubstitutions":{"value":44},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000666","node_attrs":{"div":70,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9307780265808105}},"branch_attrs":{"mutations":{"nuc":["C2790T","C9344T","A9424G","C10198T","C17410T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21762C","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","T21846C","-21987A","-21988T","-21989G","-21990T","-21991T","-21992T","-21993A","-21994T","-21995T","-22194A","-22195T","-22196T","T22200G","A22688G","A22786C","A22898G","C25000T","C25584T","G27382C","A27383T","T27384C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-"],"ORF1a":["T842I","L3027F"],"ORF1b":["R1315C","T2163I"],"ORF6":["D61L"],"S":["T19I","L24-","P25-","P26-","A27S","V67A","-69H","-70V","I95T","-142D","-143V","-144Y","D145Y","-211N","I212L","V213G","T376A","R408S","S446G"]},"labels":{"aa":"ORF1a: T842I, L3027F; ORF1b: R1315C, T2163I; ORF6: D61L; S: T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G","clade":"21L","spike_mutations":"T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G"}},"children":[{"name":"BA.2","node_attrs":{"div":70,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9307780265808105}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.16","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.223683834075928}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.828702449798584}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.19"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.502110004425049}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":129,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.8217399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.87.1"},"totalAminoacidDeletions":{"value":41},"immune_escape":{"value":"0.6657453429914796"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"NODE_0000668","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4827568531036377}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.958770990371704}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0617406368255615}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9340405464172363}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.24"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.01261797446067892"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.043281078338623}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.26"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5770962238311768}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.28","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.28"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.954390048980713}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.29"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.246047258377075}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.27","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.27"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9474263191223145}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.30","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.30"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.186139106750488}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.32"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.723714828491211}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.39","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.39"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.4","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7227389812469482}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.41","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.41"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7298529148101807}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.42","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.42"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.43"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.411208152770996}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.46","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.46"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.78423547744751}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.48","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.48"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-01"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7899765968322754}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.50"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.211312770843506}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.5","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5876340866088867}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.54","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.54"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.137404441833496}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.58"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.05063533782959}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.55","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.55"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.214793682098389}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.59","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.59"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.600702285766602}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.60","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.60"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.61","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.61"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.497011184692383}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.62"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9947850704193115}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.63","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.63"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17851448059082}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.65","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.65"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8447577953338623}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.64","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.64"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5229573249816895}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.70","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.70"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.472323894500732}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":81,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9213199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.77"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3221048136122174"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.605336666107178}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-28"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.326139211654663}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":89,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.12534"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.83"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.22071783986880583"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.82","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.82"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.2169976234436035}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.85","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.85"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.299220561981201}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000669","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000670","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.123861312866211}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.123861312866211}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.867143630981445}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000672","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.892359733581543}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.35","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.35"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.569701671600342}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.33","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.33"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086283206939697}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}}]},{"name":"internal_ad79","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.795884370803833}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.795884370803833}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.748093843460083}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000674","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9647769927978516}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9647769927978516}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.696688175201416}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"NODE_0000675","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636352777481079}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636352777481079}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.4","node_attrs":{"div":83,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.73328"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3166622371297313"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-09"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.095335006713867}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"BA.2.10.3","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.07940673828125}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.2","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6844911575317383}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"internal_ffa6","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4720098972320557}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4720098972320557}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.09519000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.6181860283242497"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000677","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.6233294010162354}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6388018131256104}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.22"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2793378829956055}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.34"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.040848255157471}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.36"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0697343349456787}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.45","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.45"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-23"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6386520862579346}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.47","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.47"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.130117893218994}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.49"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7807652950286865}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.53","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.53"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.51","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.51"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.694986581802368}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.52"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8800220489501953}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.6","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6629879474639893}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.69"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.939220905303955}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.7","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3562943935394287}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.71","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.71"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.660242795944214}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.72","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.72"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.616490125656128}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10838000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.80"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.31190394480802347"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6446309089660645}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.81"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.347172260284424}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25.1","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.99613094329834}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BA.2.25","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8e5d","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.7391467094421387}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.44"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-21"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.218840599060059}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.024046421051025}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000681","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1916520595550537}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1916520595550537}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":83,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.2","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.620241165161133}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.3","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3528671264648438}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.4","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2389769554138184}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5045342445373535}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":81,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000682","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.10","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.098408222198486}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.11","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7979328632354736}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.12","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.15","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8729300498962402}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.13","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3481757640838623}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.958418846130371}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.17","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8992514610290527}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.19","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.19"},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.70237398147583}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.18","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.462869644165039}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.4","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.5","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3020405769348145}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.7","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.8","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8521335124969482}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":86,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9456899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.43687237373984505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601434707641602}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06758"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.828201770782471}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":87,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"DD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9683399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4733677107846063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000685","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17149543762207}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":85,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.37526000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.22"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.42289430257523936"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0095014572143555}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000687","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.1","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.6589000000000002"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.6029918987948071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.66194"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.49181526572268314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.2","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.66821"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.4975483601650658"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000688","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.8190299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7593324873420084"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000689","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.91683"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7016283989012374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":104,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9440299999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8143059671640498"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.2","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"CM.5.1","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}}]},{"name":"internal_fc49","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.99403"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7255583352017505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000693","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1.2","node_attrs":{"div":103,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.4","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000694","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":104,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000695","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":107,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"FV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.28625999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0761544902802131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.35566999999999993"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0179803928276123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000698","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000699","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9729599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9785485534494837"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000700","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1288509368896484}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.1123433113098145}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.21"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.37"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-03"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.100731134414673}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.57"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.165760517120361}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.66"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.677023410797119}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.68"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.937255382537842}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.73"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0411696434021}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.21698000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.74"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.33134042675697756"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8886804580688477}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.78"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.664361953735352}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000701","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.096076011657715}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.67"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000702","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000703","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000704","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.18492"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.2640232066165751"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4447848796844482}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-06"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4447848796844482}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.08445999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.07383293656037815"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":82,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.370455061085298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.580877304077148}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000707","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.987913131713867}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0862932205200195}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000708","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.91279411315918}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.449609756469727}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07350000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.062348652344665065"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000710","node_attrs":{"div":75,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0579044818878174}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":75,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0579044818878174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000711","node_attrs":{"div":77,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292837142944336}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":80,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.4","node_attrs":{"div":82,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.3","node_attrs":{"div":79,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.5","node_attrs":{"div":79,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-28"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.2","node_attrs":{"div":85,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-18"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.7","node_attrs":{"div":84,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.6","node_attrs":{"div":80,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}}]}]}]},{"name":"NODE_0000712","node_attrs":{"div":88,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":88,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.499692916870117}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.8","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04854"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.544774532318115}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.514627933502197}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.4722700119018555}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.13451"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.4722700119018555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000715","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.378986120223999}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"BR.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b66e","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.24593"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5588825437629772"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000717","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.12575999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7451886007636047"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000718","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.10514"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5013910005227346"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000719","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}},{"name":"BR.5","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000721","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210728645324707}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.16854"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000722","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590982437133789}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590982437133789}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000723","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.19193"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.3464399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.56756"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6011952983295785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.1.2","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.6","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.11979"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5544855553668998"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.681193828582764}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.681193828582764}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_147e","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{}}},{"name":"CA.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.716528415679932}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.4","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.6","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"CA.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"internal_80b8","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.2371799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"NODE_0000730","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096992492675781}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096992492675781}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78438138961792}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.653690335850791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.11385"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5060716304521155"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000733","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.8","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.5340599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9193315170816834"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.7","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"NODE_0000734","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000735","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000736","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1331"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7470314258752732"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.31233"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7815531080803261"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000737","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000738","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":106,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}},{"name":"BN.1.4.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}}]}]},{"name":"NODE_0000739","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.136174201965332}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.220160484313965}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000740","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.21326"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7326886306518271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.4","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.6","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.8","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000741","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000742","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1.2","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.3","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000743","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49798059463501}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.2","node_attrs":{"div":102,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}},{"name":"DS.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.16291"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0513083167390975"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.12","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.9","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.3","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":102,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.6","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}},{"name":"BN.1.3.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}}]}]}]}]}]},{"name":"NODE_0000750","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.6","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"BM.5","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.03087854385376}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000751","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.26994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5272935807019111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"BM.2","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000752","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.78817"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000755","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.43724"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000758","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.87567"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9457248359372292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000759","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3.1","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000761","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000762","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000763","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":104,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000764","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000765","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":118,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000769","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852804660797119}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.0219999999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.36891999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7685109779549473"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":95,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":95,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000773","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"23C"},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"ace2_binding":{"value":"0.08511000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7a:59-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9441222497200389"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000774","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000775","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1.1","node_attrs":{"div":107,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}},{"name":"GQ.1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000776","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.24","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.29","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000777","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"internal_ddb1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":109,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000785","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000786","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.7","node_attrs":{"div":117,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}},{"name":"DV.7.1.6","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}}]},{"name":"internal_38689e19","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":114,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":118,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":119,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000790","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.3","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000791","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000792","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000793","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.3","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}},{"name":"GP.2","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}}]},{"name":"NODE_0000794","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462465286255}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.22","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.23","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.30","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.6","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.8","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000795","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000796","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000797","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000798","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1.1","node_attrs":{"div":115,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}},{"name":"JP.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"internal_7d467e42","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.2","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}},{"name":"FK.1.2.1","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}}]},{"name":"internal_d1673169","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}},{"name":"FK.1.4","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000804","node_attrs":{"div":107,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":109,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}},{"name":"FK.1.1.1","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.16085999999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9815994835819151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_5be7761b","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["T241-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["-241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000807","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000808","node_attrs":{"div":118,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"LV.2","node_attrs":{"div":132,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000809","node_attrs":{"div":120,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.68471097946167}},"branch_attrs":{"mutations":{"nuc":["C21T","T13339C"]}},"children":[{"name":"BA.2.86","node_attrs":{"div":120,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-17"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.68471097946167}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":121,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000810","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}}]},{"name":"NODE_0000811","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-13"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000812","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.6738025507980547"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000813","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000814","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.15919"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-05"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000815","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-20"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":137,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":134,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000816","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.804112911224365}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.519156455993652}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000817","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.16","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.15","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.15"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.17","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.14","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.19","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.19"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.18","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.6","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.8","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"NODE_0000818","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11.1","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.11","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000819","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000820","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","C6525T","C29171T"],"N":["H300Y"],"ORF1a":["P892S","T2087I"]},"labels":{"aa":"N: H300Y; ORF1a: P892S, T2087I"}},"children":[{"name":"JN.3.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.3.2","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000821","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":132,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.6465599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000822","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}}]},{"name":"internal_59b29264","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000824","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000825","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.503751754760742}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000826","node_attrs":{"div":128,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7886734008789062}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":128,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-29"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7886734008789062}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.413212776184082}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.26806999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2179718017578125}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9045636653900146}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063994884490967}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.875786304473877}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.6742007732391357}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4943132400512695}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.498900413513184}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407996654510498}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.0337066650390625}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.46","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.232485294342041}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.45","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2978410720825195}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.5","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.8044490814208984}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.117572784423828}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.344854354858398}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.61","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.93036"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.496607246855186"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4297661781311035}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.67","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.5563645362854}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}}},{"name":"JN.1.66","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086506843566895}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086506843566895}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.2.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.971957206726074}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240969657897949}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-20"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240969657897949}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013700485229492}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.323051452636719}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013700485229492}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.16291618347168}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.16291618347168}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.261717796325684}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.847394943237305}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.847394943237305}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3922882080078125}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3922882080078125}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741697788238525}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.846282005310059}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.44","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741697788238525}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.501391887664795}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.501391887664795}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.05681999999999991"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.532734695870142"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9070000648498535}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9070000648498535}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.56.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.7602899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5395016697354735"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803360939025879}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":8.507},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}},{"name":"JN.1.59","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803360939025879}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235310077667236}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235310077667236}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4939866065979}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000838","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1673784255981445}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.744482040405273}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}},{"name":"JN.1.63","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1673784255981445}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_4e516d94","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.049008369445801}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.049008369445801}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.251441478729248}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.251441478729248}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395014762878418}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395014762878418}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.455239772796631}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332273483276367}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332273483276367}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.063151836395264}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005981922149658}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.993703842163086}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005981922149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.405921936035156}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.405921936035156}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082502841949463}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082502841949463}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.514431953430176}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.514431953430176}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.825034141540527}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"NODE_0000850","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.62","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-08"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","G23604A"],"S":["V62F","R681H"]},"labels":{"aa":"S: V62F, R681H","spike_mutations":"V62F, R681H"}}},{"name":"NODE_0000851","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{"nuc":["G4162A","G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MZ.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9003684520721436}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9003684520721436}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.853470802307129}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.176589012145996}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.56445837020874}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.965569496154785}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.965569496154785}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.303284645080566}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439889430999756}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439889430999756}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MS.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217808246612549}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-18"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"ME.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.27215999999999985"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894906520843506}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894906520843506}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834674835205078}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834674835205078}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000860","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2595099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.2","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}},{"name":"MF.1","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343885898590088}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343885898590088}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000864","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548393249511719}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548393249511719}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693490982055664}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.125247478485107}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566946029663086}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000868","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"internal_137393d6","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000871","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000872","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4388251304626465}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000873","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.779577732086182}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.779577732086182}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753198623657227}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":141,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-20"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.396686553955078}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":96},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000879","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.62368106842041}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.62368106842041}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000880","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000881","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.9318500000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3745641202332524"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000882","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000883","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7748894691467285}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.327071189880371}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7748894691467285}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5151262283325195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000887","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000888","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MV.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.30217999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000889","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309098243713379}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309098243713379}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.409302234649658}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.224720478057861}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.8731584548950195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.8731584548950195}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.486703395843506}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.53473424911499}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.53473424911499}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3433942794799805}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3433942794799805}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917654037475586}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917654037475586}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.225796699523926}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005701065063477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1.3","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.098504066467285}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.57","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_dd754174","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.730973243713379}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.730973243713379}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.287435054779053}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.08313"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.566638469696045}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69068717956543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.6","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.7","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.175660610198975}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.9","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000903","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000904","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}},{"name":"MQ.2","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.04395"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{}}},{"name":"LK.2.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.95433"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.712064027786255}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.776793003082275}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.712064027786255}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.4","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.743773937225342}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1655168533325195}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000909","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.8164446353912354}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0372114181518555}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.78267240524292}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.78267240524292}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000913","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769777297973633}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769777297973633}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145885944366455}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000914","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5280601978302}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5280601978302}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"internal_e3b87428","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6427741050720215}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6427741050720215}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000917","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.973682403564453}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.973682403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621864318847656}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621864318847656}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000921","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227319717407227}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.88560676574707}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.850419044494629}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000922","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000923","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":142,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":11.111},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000924","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.2","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.3","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"internal_3e3e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056468486785889}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056468486785889}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.607524394989014}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.143589496612549}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.143589496612549}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.6","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.9","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"LB.1.8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"NODE_0000928","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.3"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-24"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000929","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.662585735321045}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}},{"name":"LB.1.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.3","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000931","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883640289307}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883640289307}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.472174644470215}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347520351409912}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.416768550872803}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.416768550872803}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LA.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.04741999999999978"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"S":["T346I"]},"labels":{"aa":"S: T346I","spike_mutations":"T346I"}}},{"name":"LA.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685051918029785}},"branch_attrs":{"mutations":{"nuc":["T22599C"]}}}]}]},{"name":"NODE_0000936","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.71908712387085}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012791156768799}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MT.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_acb00454","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.085048198699951}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.085048198699951}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":50.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21767999999999987"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.817229820305529"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LF.3.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}}]}]},{"name":"NODE_0000944","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671684741973877}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671684741973877}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000945","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9.1"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000946","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000947","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}},{"name":"LF.8.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.107455253601074}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.107455253601074}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958076000213623}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958076000213623}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688903331756592}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688903331756592}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.83402681350708}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.83402681350708}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.795686721801758}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":11.111},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3926199999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451968669891357}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451968669891357}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.52098274230957}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}},{"name":"LQ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000957","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.106265068054199}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172470569610596}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172470569610596}},"branch_attrs":{"mutations":{}}},{"name":"LY.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}},{"name":"LY.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}}]},{"name":"NODE_0000960","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]},{"name":"NODE_0000962","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}},{"name":"LZ.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":132,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299810886383057}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":132,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299810886383057}},"branch_attrs":{"mutations":{}}},{"name":"KP.6","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.04741999999999978"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.009568691253662}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"KP.5","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.512091159820557}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000966","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.27333999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7741516492587035"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000970","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679379463195801}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-22"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679379463195801}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MU.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923413038253784}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923413038253784}},"branch_attrs":{"mutations":{}}},{"name":"LP.3","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.4","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_bfd296bd","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928688049316}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928688049316}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000976","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000977","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013410568237305}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013410568237305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.11","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.12","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.1","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.616664409637451}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.19","node_attrs":{"div":140,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.19"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.23"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.24"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.083328723907471}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.0966644287109375}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000981","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7908990401504723"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.4","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.3","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000982","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":140,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MW.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":96},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000983","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.91617751121521}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.21942999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.17","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.16","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.532774448394775}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.18"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.196527481079102}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.22"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000984","node_attrs":{"div":133,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987264633178711}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":133,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987264633178711}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.6","node_attrs":{"div":134,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.770003318786621}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.3.5","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"internal_123a0013","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094734191894531}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094734191894531}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":141,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.2","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5554650921238282"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"KP.3.3.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"NODE_0000987","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MR.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9914960861206055}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2.1","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9914960861206055}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.2","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.5","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-09"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.35004997253418}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"KP.3.2.4","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.093895435333252}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"internal_f3994b77","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000991","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":142,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":142,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000992","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000993","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":141,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MY.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000995","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":143,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.11924"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7206397516519647"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000997","node_attrs":{"div":137,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":137,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.10"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.12"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.14"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.15","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.15"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.16"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.3","node_attrs":{"div":142,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.4","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.6","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.5","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.7","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5369762101413171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000998","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":140,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000999","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13.1","node_attrs":{"div":140,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}},{"name":"MC.13","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2.1","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}},{"name":"MC.2","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_836f2465","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":142,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.767807722091675}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0001003","node_attrs":{"div":75,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.517561435699463}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":75,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.517561435699463}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001004","node_attrs":{"div":76,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.3251705169677734}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":76,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.3251705169677734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0001005","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.9142704010009766}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.5","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.3","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.7","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0001006","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.1","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-05"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.3","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.71883"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.2","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.4","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0001007","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":82,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"DC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.66094"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"internal_813c","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.69476318359375}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.69476318359375}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.5","node_attrs":{"div":79,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.4","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.6","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.9","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.872365713119507}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"BA.4.1.8"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001009","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001010","node_attrs":{"div":79,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":86,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0001011","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.67074"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5308081831240151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":87,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"CS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5702799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.7561969850799493"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0001012","node_attrs":{"div":83,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.145464897155762}},"branch_attrs":{"mutations":{"nuc":["C1931A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF1a":["Q556K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF1a: Q556K; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.918104648590088}},"branch_attrs":{"mutations":{"nuc":["A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}}},{"name":"BA.5.3.1","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.109306812286377}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"BA.5.3","node_attrs":{"div":83,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.145464897155762}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:72-122"},"partiallyAliased":{"value":"BA.5.3.3"},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.781851291656494}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.5"},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.9","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2392046451568604}},"branch_attrs":{"mutations":{"nuc":["T1570C","A1931C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["K556Q","T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: K556Q, T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"BE.2","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.800013303756714}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T","G28681T"],"N":["E136D"],"ORF1a":["T882I"]},"labels":{"aa":"N: E136D; ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.220089912414551}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","G28681T","C28724T"],"N":["E136D","P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: E136D, P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.109306812286377}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"NODE_0001013","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8083324432373047}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.4","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.250558853149414}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}},{"name":"BA.5.3.2","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.920682430267334}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}}]},{"name":"NODE_0001014","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.902167558670044}},"branch_attrs":{"mutations":{"nuc":["A1931C","A6551C","G29032A"],"ORF1a":["K556Q","M2096L"]},"labels":{"aa":"ORF1a: K556Q, M2096L"}},"children":[{"name":"BA.5.8","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}},{"name":"BA.5.7","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}}]},{"name":"NODE_0001015","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420078754425049}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A","G28681T"],"N":["E136D"],"S":["K444T","N460K"]},"labels":{"aa":"N: E136D; S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6684834957122803}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0001016","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2845587730407715}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","G28681T","T28693C"],"N":["E136D"],"ORF1a":["M85-"]},"labels":{"aa":"N: E136D; ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.6"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.737102031707764}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.7"},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.387746334075928}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001017","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.943603277206421}},"branch_attrs":{"mutations":{"nuc":["A1931C","C21789T"],"ORF1a":["K556Q"],"S":["T76I"]},"labels":{"aa":"ORF1a: K556Q; S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.243032455444336}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"BA.5.5","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.943603277206421}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001018","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891446590423584}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5124127864837646}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0001019","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.720151901245117}},"branch_attrs":{"mutations":{"nuc":["G28681T","T28693C"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BE.12","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0075602531433105}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0001020","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236769199371338}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5231200000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.13"},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.5088823627149919"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.8"},"totalAminoacidDeletions":{"value":94},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":1},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0001021","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T","G28681T"],"N":["E136D"],"ORF1a":["T3308N"]},"labels":{"aa":"N: E136D; ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001022","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281350135803223}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0001023","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001024","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.919694185256958}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0001025","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0001026","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075679063796997}},"branch_attrs":{"mutations":{"nuc":["A1931C","T4906C","C17402T","T18957C","C21077T"],"ORF1a":["K556Q"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1a: K556Q; ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075679063796997}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001027","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130266189575195}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.4","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5883099999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}},{"name":"BA.5.6.3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001028","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001029","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6570799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0001030","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-20"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}}]}]}]}]},{"name":"NODE_0001031","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2636122703552246}},"branch_attrs":{"mutations":{"nuc":["A1T","A1931C","T27438C","C29666T"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.1","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2636122703552246}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.11","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.12","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.42498517036438}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.9656171798706055}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.953991413116455}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.774555206298828}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.263641834259033}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.364013195037842}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.3","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1492865085601807}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.28","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.255985736846924}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.30","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9020943641662598}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.34"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0658464431762695}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.146693468093872}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.6","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.541465997695923}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.4","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.7","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8861465454101562}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.8","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6324868202209473}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0001032","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9345109462738037}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0001034","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213008403778076}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213008403778076}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0001035","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.302816867828369}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198367118835449}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198367118835449}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001038","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.846538543701172}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.846538543701172}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1157443523406982}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.33618688583374}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}},{"name":"DE.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}}]}]},{"name":"NODE_0001041","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4297988414764404}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-28"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001042","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069684028625488}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069684028625488}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806603193283081}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806603193283081}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.106252193450928}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.106252193450928}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001045","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.244868278503418}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.3","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-23"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"DJ.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-10"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0001046","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.52162766456604}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.1.27"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001049","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0001050","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0001051","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7331035137176514}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.082880973815918}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047396659851074}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-15"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.180698871612549}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0001052","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127193450927734}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.532985687255859}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.36","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"NODE_0001053","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024437427520752}},"branch_attrs":{"mutations":{"nuc":["G16935A","G28681T"],"N":["E136D"],"ORF1b":["M1156I"]},"labels":{"aa":"N: E136D; ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024437427520752}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0001054","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.29529333114624}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.29529333114624}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001055","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.49383999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8224959014481948"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0001056","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.3","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"BE.1.4.4","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0001057","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0001058","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708044052124023}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708044052124023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001059","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0001060","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036477565765381}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036477565765381}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45205000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5680790723509552"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.677981853485107}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0001061","node_attrs":{"div":91,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3800950050354004}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":91,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3800950050354004}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3855841159820557}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.436852216720581}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6127800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7257362514460642"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.20","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5446"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8308113969466171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4570536613464355}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6570799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.423999309539795}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.428560256958008}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.4","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.33","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.946379661560059}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.6","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.5","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.459336757659912}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.7","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.914120197296143}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.9","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6576948165893555}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001062","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-26"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0001063","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0001064","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0001065","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001066","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009603500366211}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"NODE_0001067","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710107326507568}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710107326507568}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001068","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"internal_56b3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0001071","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0001073","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6353800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6853534127590314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688453674316406}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2.3","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875691413879395}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"BQ.1.2","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688453674316406}},"branch_attrs":{"mutations":{}}},{"name":"internal_dbfb","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5174000000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6925976779449897"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001078","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":105,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66664"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9874397743924017"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0001079","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-28"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":109,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6059300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:83-122"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"totalAminoacidDeletions":{"value":31},"immune_escape":{"value":"1.0821590912755812"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7586400508880615}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.546395778656006}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.23","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4521584510803223}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.057005405426025}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.637411117553711}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":102,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0001083","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.392918109893799}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-09"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.392918109893799}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.891563892364502}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.535731792449951}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.19","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.225134372711182}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.17","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1496901512146}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.21","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.20","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.5311388969421387}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.25","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7449699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.073443412780762}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5921799999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8728938682420008"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.841209411621094}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8330562114715576}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.36","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.201071739196777}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.314393997192383}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.34","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.40","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.44","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.068432331085205}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.45","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7044315338134766}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.41","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9046695232391357}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.47","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.249931335449219}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.386255741119385}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995408058166504}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.861392974853516}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.56","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530673980712891}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.57","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.360785007476807}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.58","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.378429889678955}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.6","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.975255012512207}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.60","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.916863918304443}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.63","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.371269702911377}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.67","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.056057929992676}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.66","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276078224182129}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.70","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.841140031814575}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.69","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.636171579360962}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.75","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.051732686328446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.239450931549072}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.731176376342773}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.202805519104004}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.202805519104004}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.70602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.662565231323242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0001085","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.960555553436279}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001086","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-19"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-12"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0001087","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.942427635192871}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.780996322631836}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-02"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530292510986328}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0001088","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500977516174316}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ET.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0001090","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ES.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001091","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.74371"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-30"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.994874000549316}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452495098114014}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452495098114014}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918554306030273}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bf35","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.695047378540039}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.695047378540039}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001094","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66913"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9105813557217661"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6774299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001096","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.908818006515503}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.908818006515503}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.810004711151123}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.999442100524902}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0001097","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001098","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0001099","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.548947811126709}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001100","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001101","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0001102","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6486213207244873}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.388934135437012}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.766948223114014}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.134593486785889}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.134593486785889}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478137016296387}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.34834999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.880706782961692"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9221577644348145}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_1117","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504772186279297}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504772186279297}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.8300909996032715}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.499401330947876}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.499401330947876}},"branch_attrs":{"mutations":{}}},{"name":"ED.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1880574226379395}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.897567272186279}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0001106","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.167686462402344}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0001107","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002800464630127}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002800464630127}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.66091775894165}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.224764823913574}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.117682456970215}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302685260772705}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0001111","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.18422269821167}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131554126739502}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.522237777709961}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.840278148651123}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0001113","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.255103588104248}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0001114","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-24"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.3","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"EW.2","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}}]},{"name":"NODE_0001115","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0001116","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":102,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-17"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0001117","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":103,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0001118","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.141738414764404}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.141738414764404}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.071822166442871}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.241168022155762}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001120","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138625144958496}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001122","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0001123","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6995503902435303}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0001124","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-7.3331193923950195}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0001125","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001126","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.1","node_attrs":{"div":104,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"2.05606"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8990816968865659"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.2","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5626099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8771384492554943"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6722600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8744814686582322"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.3","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}}]}]}]}]}]}]}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1467015743255615}},"branch_attrs":{"mutations":{"nuc":["C1627T","A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.11","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.11"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.792257070541382}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001129","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001130","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0001131","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6492786407470703}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6492786407470703}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001132","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6364240646362305}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6364240646362305}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5279"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.933121919631958}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.076331377029419}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"ORF1b":["H1087Y"],"S":["N450D"]},"labels":{"aa":"ORF1b: H1087Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.18","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.087855815887451}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.19","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.17","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.484903812408447}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.2","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4420108795166016}},"branch_attrs":{"mutations":{"nuc":["T6979G","G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.100374221801758}},"branch_attrs":{"mutations":{"nuc":["A396T","T6979G"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.30","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6034899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.35","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"],"S":["N450D"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.36","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8252875804901123}},"branch_attrs":{"mutations":{"nuc":["A761G","T6979G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.4","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5455124378204346}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.914348602294922}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4831809997558594}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"BF.9","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4603519439697266}},"branch_attrs":{"mutations":{"nuc":["G5555A","T6979G","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0001133","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4077556133270264}},"branch_attrs":{"mutations":{"nuc":["T4690C","T6979G","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4077556133270264}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0001134","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.132326364517212}},"branch_attrs":{"mutations":{"nuc":["T6979G","C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.132326364517212}},"branch_attrs":{"mutations":{}}},{"name":"BF.10.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.3218"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.563032084337257"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}}]},{"name":"NODE_0001135","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1162216663360596}},"branch_attrs":{"mutations":{"nuc":["T6979G","C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.380282402038574}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.539719581604004}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0001136","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4314894676208496}},"branch_attrs":{"mutations":{"nuc":["T6979G","C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3808767795562744}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0001137","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.251821517944336}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.251821517944336}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.985884428024292}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.33263"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5959379308450252"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.378326892852783}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.985884428024292}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112126350402832}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112126350402832}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001140","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.462851047515869}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0001141","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.165992736816406}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.292901039123535}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0001142","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.430593729019165}},"branch_attrs":{"mutations":{"nuc":["A3859G","T6979G"]}},"children":[{"name":"BF.16","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36989164352417}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.13","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.22","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5231502056121826}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.734994888305664}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.34"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6532351970672607}},"branch_attrs":{"mutations":{"nuc":["T6979G","G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.735113620758057}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.314535617828369}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.314535617828369}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.48889999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2785773277282715}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0001145","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.552170276641846}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6700541973114014}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0001146","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160181045532227}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160181045532227}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001147","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.755500316619873}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0001148","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.070246458053589}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.266221046447754}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001149","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.60558819770813}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0001150","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.3","node_attrs":{"div":116,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-08"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}},{"name":"BF.5.2","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.603853225708008}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"BA.5.2.1.42"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.39715313911438}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257153511047363}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416705131530762}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2871978282928467}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238437175750732}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238437175750732}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.085692405700684}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0001154","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.84029483795166}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.84029483795166}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-05"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.12","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.11","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.15","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6393200000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.23","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.21","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.24","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.26","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.6","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.8","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.7","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.9","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0001155","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001156","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0001157","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001158","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.2","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}}]},{"name":"NODE_0001159","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0001160","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3122615814208984}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0001161","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0001162","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-25"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.4","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.7","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"BF.7.14.5","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"NODE_0001163","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.3","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.2","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.6","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0001164","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6319823265075684}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8151323795318604}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.182566165924072}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9923171997070312}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0001165","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-1.9059104919433594}},"branch_attrs":{"mutations":{"nuc":["C16616A","C27012T","C27513T"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3895606994628906}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6929638385772705}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7767930030822754}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.22","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4965717792510986}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.28","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1461098194122314}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.30","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523481845855713}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.29","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.456769943237305}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.34","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.34"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.511476755142212}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.394333839416504}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.42"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.44","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.44"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278106212615967}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.43","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5642800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.43"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5413273873731987"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.46","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.46"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.212985038757324}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.45","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5131699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.45"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998797416687012}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.54","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.54"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.171896934509277}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.52","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.52"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112395763397217}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.55"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.987527847290039}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.53","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.53"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.224037170410156}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.57","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.57"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.694659471511841}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.58","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.58"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236799716949463}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.61","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.61"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.711515426635742}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.63","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.63"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-14"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.59","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.59"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1926188468933105}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.5.2.62","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.62"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162878036499023}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.8","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9392523765563965}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.285115718841553}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.365017890930176}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782564401626587}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782564401626587}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796359539031982}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"NODE_0001168","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3798828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"internal_1651","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162424087524414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162424087524414}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4564899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7208595659836455"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.671617031097412}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.313830852508545}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.56458"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.30660604695253"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.313830852508545}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.4733147621154785}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001171","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.635266304016113}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.56"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.025681972503662}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0001173","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0985677242279053}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0985677242279053}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.277458667755127}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"internal_d5b0","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4673573970794678}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4673573970794678}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{}}},{"name":"BZ.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}},{"name":"BZ.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_74ef","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.5325236320495605}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5594199999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3253063676642168"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0001177","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]},{"name":"NODE_0001178","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.059089183807373}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.51","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.51"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.50","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.50"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-21"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.72301721572876}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.60","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.60"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0001179","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{}}},{"name":"CY.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.678462505340576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}},{"name":"CY.2","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}}]},{"name":"NODE_0001180","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.246817111968994}},"branch_attrs":{"mutations":{"nuc":["T27012C","T27513C"]}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.743002891540527}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.62591552734375}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0001181","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8558647632598877}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8558647632598877}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]}]},{"name":"NODE_0001182","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.204470634460449}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-25"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.356487274169922}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DB.3","node_attrs":{"div":107,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}}]},{"name":"NODE_0001185","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.905637264251709}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"internal_f379","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.66318941116333}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.66318941116333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001187","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36233377456665}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}},{"name":"CR.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0001188","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7050411701202393}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0001189","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8912155628204346}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]},{"name":"NODE_0001190","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}},{"name":"DY.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_7385","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.201568603515625}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.201568603515625}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.38661"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.82891845703125}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.4","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.628321170806885}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6942999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.5295255377787571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.5","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.973639488220215}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-02"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.6","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.885843276977539}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"internal_7ebe","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}}]},{"name":"NODE_0001193","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.384389877319336}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.319447994232178}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}},{"name":"CP.1.3","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6003199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"NODE_0001194","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047609329223633}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047609329223633}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.240954875946045}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.374807834625244}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.374807834625244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001197","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0001198","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.068063735961914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.068063735961914}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0001199","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.98232364654541}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.71883"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998134136199951}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.711119651794434}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0001200","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.607345104217529}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0001201","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-29"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.657632350921631}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-02-18","#531EA6"],["2021-02-21","#521EA7"],["2021-03-02","#4E20AC"],["2021-03-10","#4C24AF"],["2021-03-15","#4B26B1"],["2021-04-01","#472DB8"],["2021-04-07","#462FBA"],["2021-04-08","#4530BB"],["2021-04-13","#4432BD"],["2021-04-19","#4334BF"],["2021-04-20","#4335C0"],["2021-04-21","#4235C0"],["2021-04-23","#4236C1"],["2021-04-26","#4137C2"],["2021-04-30","#4039C4"],["2021-05-05","#403BC5"],["2021-05-13","#4040C6"],["2021-05-16","#4041C7"],["2021-05-21","#3F44C8"],["2021-05-25","#3F46C8"],["2021-05-26","#3F46C9"],["2021-06-04","#3F4BCA"],["2021-06-14","#3F50CC"],["2021-06-18","#3F53CD"],["2021-06-19","#3F53CD"],["2021-06-25","#3F56CE"],["2021-06-30","#3E59CF"],["2021-07-01","#3E59CF"],["2021-07-13","#3F5FD0"],["2021-07-22","#4064CF"],["2021-07-23","#4064CF"],["2021-07-26","#4066CF"],["2021-07-27","#4066CF"],["2021-07-28","#4067CF"],["2021-07-30","#4068CF"],["2021-08-02","#4169CF"],["2021-08-03","#416ACF"],["2021-08-04","#416ACF"],["2021-08-07","#416CCE"],["2021-08-09","#416DCE"],["2021-08-10","#416DCE"],["2021-08-12","#416ECE"],["2021-08-13","#416FCE"],["2021-08-16","#4270CE"],["2021-08-17","#4271CE"],["2021-08-18","#4271CE"],["2021-08-19","#4271CE"],["2021-08-22","#4273CE"],["2021-08-25","#4374CD"],["2021-08-27","#4375CD"],["2021-09-02","#4378CD"],["2021-09-03","#4379CD"],["2021-09-13","#447DCC"],["2021-09-20","#4580CA"],["2021-09-23","#4681C9"],["2021-09-24","#4682C9"],["2021-09-27","#4783C8"],["2021-09-29","#4783C8"],["2021-09-30","#4784C8"],["2021-10-04","#4885C7"],["2021-10-08","#4887C6"],["2021-10-11","#4988C5"],["2021-10-12","#4988C5"],["2021-10-18","#4A8BC3"],["2021-10-22","#4A8CC2"],["2021-10-25","#4B8DC2"],["2021-10-27","#4B8EC1"],["2021-10-28","#4B8FC1"],["2021-11-02","#4C91C0"],["2021-11-04","#4C91BF"],["2021-11-05","#4D92BF"],["2021-11-17","#4F96BC"],["2021-11-18","#4F96BB"],["2021-11-19","#4F97BB"],["2021-11-23","#5098BA"],["2021-11-24","#5098B9"],["2021-11-25","#5098B9"],["2021-11-29","#5199B7"],["2021-12-03","#529AB6"],["2021-12-07","#539BB4"],["2021-12-08","#539CB4"],["2021-12-10","#539CB3"],["2021-12-13","#549DB2"],["2021-12-14","#549DB2"],["2021-12-17","#559EB1"],["2021-12-19","#559FB0"],["2021-12-21","#569FAF"],["2021-12-22","#56A0AF"],["2021-12-26","#57A1AE"],["2021-12-28","#57A1AD"],["2022-01-01","#58A2AB"],["2022-01-05","#59A3AA"],["2022-01-07","#59A4A9"],["2022-02-16","#63AC99"],["2022-02-23","#65AD96"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-29","#6FB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-21","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Beta","#4067CF"],["Gamma","#4A8BC3"],["Delta","#5AA4A9"],["Epsilon","#6FB488"],["Eta","#8BBB69"],["Theta","#A9BD53"],["Iota","#C7B944"],["Kappa","#DDA93C"],["Lambda","#E68A35"],["Mu","#E35C2C"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","clade_who","clade_display","designation_date","designation_recency"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":true},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":false},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{},"labels":{"clade":"19A"}},"children":[{"name":"B","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":0},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{"ORF6":["D61L"],"S":["T19I"]},"labels":{"aa":"ORF6: D61L; S: T19I","spike_mutations":"T19I"}},"children":[{"name":"XAA","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAA"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A1610G","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C8247T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12445T","C12880T","C14408T","C15714T","C17410T","A18163G","A19356G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["N449D","K856R","S2083-","L2084I","S2661F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: N449D, K856R, S2083-, L2084I, S2661F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XA","node_attrs":{"div":33,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XA"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-05"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T445C","T2019C","C3037T","C4999T","C6286T","C8090T","C9430T","A10323G","C13945T","C14408T","G20410A","G21255C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23208T","C23271A","A23403G","C23604A","C23709T","T24506G","G24914C","G25855T","C27972T","G28048T","A28095T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"N":["D3L","R203K","G204R","S235F"],"ORF1a":["M585T","L2609F","K3353R"],"ORF1b":["P160S","P314L","E2315K"],"ORF3a":["D155Y"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","K68*","Y73C"],"S":["I19T","H69-","V70-","Y144-","N501Y","T549I","A570D","D614G","P681H","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, R203K, G204R, S235F; ORF1a: M585T, L2609F, K3353R; ORF1b: P160S, P314L, E2315K; ORF3a: D155Y; ORF6: L61D; ORF8: Q27*, R52I, K68*, Y73C; S: I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H","spike_mutations":"I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H"}}},{"name":"XAC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAC"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.851975917816162}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15720T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25731T","C25810T","C26028T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","A2909V","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["L140F"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, A2909V, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: L140F; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAB","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.443575382232666}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17010T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAF","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-","T3750I","V3751F"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-, T3750I, V3751F; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAG","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C2857T","C3037T","T5386G","C5585A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C12880T","C14408T","C15714T","C17410T","C17502T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","L1774I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, L1774I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAD","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAD"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.857146263122559}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","A1250G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T329A","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T329A, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAE","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAE"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","G4975A","A6390C","C9344T","A9424G","C9534T","C9803T","C9866T","C10029T","C10198T","G10447A","C10449A","C11249T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C","T29748C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","E2042A","L3027F","T3090I","L3201F","T3255I","P3395H","R3662C","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, E2042A, L3027F, T3090I, L3201F, T3255I, P3395H, R3662C, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAL","node_attrs":{"div":61,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","A2865G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","G21586T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","E867G","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L8F","L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, E867G, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K","spike_mutations":"L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K"}}},{"name":"XAK","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAK"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.3037714005953052"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4927T","T5386G","C7834T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C12880T","C14408T","C15240T","A18163G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","A22001G","T22200G","G22578A","G22599A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22942G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24863T","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","I1566V"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","H69-","V70-","G142D","K147E","V213G","G339D","R346K","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N460K","S477N","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","H1101Y"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, I1566V; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y","spike_mutations":"I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y"}}},{"name":"XAJ","node_attrs":{"div":72,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAJ"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.647030830383301}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11674T","C12880T","C14408T","T15009C","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","A23535G","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N658S","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XAH","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAH"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.713448524475098}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","G17242T","C17410T","A18163G","C18246T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33G","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","A1259S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33G, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, A1259S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAM","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAM"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T3750I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T3750I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAP","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAP"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-30"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9286975860595703}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C5407A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAR","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.44734525680542}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21796T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","R78S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAN","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAN"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.080811023712158}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7973A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","C17822T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","T27696C","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29666T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L2570M","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","P1452L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L2570M, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, P1452L, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAQ","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","C9857T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23779T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAT","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","C10277T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19317T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25810T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","A2909V","L3027F","T3090I","L3201F","T3255I","L3338F","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["L140F","T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, A2909V, L3027F, T3090I, L3201F, T3255I, L3338F, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: L140F, T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAV","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAV"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.706950664520264}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C6606T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15960T","G17278T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","S2114F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","V1271L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, S2114F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, V1271L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAU","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAU"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.173168659210205}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","T17407C","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAS","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAS"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.466667652130127}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAW","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAW"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.274687314409391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C335T","G569A","T689C","G1048T","G1125A","C1973T","C3037T","G3246A","G4181T","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9676C","C10029T","A10323G","A11201G","G11330A","A11332G","C11866T","C13806T","C13994T","C14408T","C14585T","G15451A","C16466T","C17304T","C17550T","A17973G","G18525A","C19220T","C19290T","C20402T","G20493A","C21575T","C21618G","C21636T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","T22942A","G22992A","C22995A","A23013C","T23042C","A23055G","A23063T","T23075C","C23114T","A23403G","C23525T","C23604A","C23854A","G23948T","G24145A","A24424T","T24469A","C25000T","C25584T","A25592G","C26060T","C26270T","C26537T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28562A","G28646A","C28849T","C28873T","G28881T","G28916T","G29402T","C29635T","G29742T"],"E":["T9I"],"M":["Q19E","A63T"],"N":["D63G","G97S","A125T","R203M","G215C","D377Y"],"ORF1a":["R24C","E102K","S142P","K261N","R287K","S994N","A1306S","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","T3255I","K3353R","T3646A","V3689M"],"ORF1b":["A176V","P314L","A373V","G662S","P1000L","A1918V","S2312L"],"ORF3a":["K67R","T223I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["L5F","I19R","P25L","E156-","F157-","R158G","N211-","L212I","L242-","A243-","G339D","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","N460K","S477N","T478K","E484A","S494P","Q498R","N501Y","Y505H","D614G","H655Y","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: D63G, G97S, A125T, R203M, G215C, D377Y; ORF1a: R24C, E102K, S142P, K261N, R287K, S994N, A1306S, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, T3255I, K3353R, T3646A, V3689M; ORF1b: A176V, P314L, A373V, G662S, P1000L, A1918V, S2312L; ORF3a: K67R, T223I; ORF8: D119-, F120-; ORF9b: T60A; S: L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAZ","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAZ"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1912T","C2232T","C2790T","C3037T","C3317T","T3358C","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A656V","T842I","P1018S","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A656V, T842I, P1018S, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XB","node_attrs":{"div":29,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"XB"},"totalAminoacidDeletions":{"value":5},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-18"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.699341297149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C3688T","C3884T","C6633T","A7142G","A9614G","C9693T","A9754C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14408T","G15451A","C16466T","C21057T","T21615G","C21846T","A22036C","A23403G","C23604A","C23625T","T23765G","C24442T","C24642T","G26158-","T26159-","T26160-","A26161-","C26222T","C27389T","C27769T","G28048A","A28271-","A28330G","C28854T","A28910T"],"N":["S194L","N213Y"],"ORF1a":["P1207S","A2123V","S2293G","T3117A","A3143V","R3163S","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","P1000L"],"ORF3a":["V256-","N257-","P258I","M260I","E261I","P262I","T269I","P274I","L275I"],"ORF6":["L61D"],"ORF7b":["S5L"],"ORF8":["R52K"],"ORF9b":["D16G"],"S":["L18R","I19T","T95I","R158S","D614G","P681H","A688V","S735A","T1027I"]},"labels":{"aa":"N: S194L, N213Y; ORF1a: P1207S, A2123V, S2293G, T3117A, A3143V, R3163S, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, P1000L; ORF3a: V256-, N257-, P258I, M260I, E261I, P262I, T269I, P274I, L275I; ORF6: L61D; ORF7b: S5L; ORF8: R52K; ORF9b: D16G; S: L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I","spike_mutations":"L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I"}}},{"name":"XBA","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBA"},"totalAminoacidDeletions":{"value":4},"immune_escape":{"value":"0.29808642936638835"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4181T","C6402T","C7124T","C8595T","C8986T","G9053T","C10029T","A11201G","A11332G","G13812T","C14408T","C14790T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","A22991G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","T26767C","G26959A","T27638C","A27663T","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","C28311T","A28461G","G28881A","G28882A","G28883C","G29402T","G29742T"],"M":["I82T","R146H"],"N":["P13L","D63G","R203K","G204R","D377Y"],"ORF1a":["S135R","T842I","A1306S","P2046L","P2287S","T2777I","V2930L","T3255I","T3646A"],"ORF1b":["M115I","P314L","A520V","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["P10S","T60A"],"S":["L18F","I19R","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477D","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","T1117I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, D63G, R203K, G204R, D377Y; ORF1a: S135R, T842I, A1306S, P2046L, P2287S, T2777I, V2930L, T3255I, T3646A; ORF1b: M115I, P314L, A520V, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: P10S, T60A; S: L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I","spike_mutations":"L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I"}}},{"name":"XBD","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBD"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBE","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBE"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.568920612335205}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27800T","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","T1050N","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, T1050N, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBH","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBH"},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-16"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7528T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13730T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25157A","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28881A","G28882A","G28883C","A29510C","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","T29758C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["A88V","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","D1199N"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: A88V, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N"}}},{"name":"XBG","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBG"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10116T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11665T","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","A24676G","C25000T","C25584T","C26060T","T26180C","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","T3284I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I","I263T"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, T3284I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I, I263T; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBM","node_attrs":{"div":74,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBM"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","G19891A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23202T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27549T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","D2142N","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","T547I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, D2142N, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBN","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBN"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","A2863G","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","A19459G","C19554T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C25638T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","I1998V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, I1998V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBP","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBP"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7303T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C12952T","C13965T","C14408T","C15277T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","T23773C","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","H604Y","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, H604Y, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBQ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBQ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G14829T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","M454I","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, M454I, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBR","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1093T","G1440A","A1964G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","A5844G","C8597T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21077T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22855T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25471C","C25553T","T25569C","C25584T","G26031A","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","G392D","I567V","T842I","S1221L","G1307S","P1640S","K1860R","L2778F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I","T2537I"],"ORF3a":["D27H","A54V","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, G392D, I567V, T842I, S1221L, G1307S, P1640S, K1860R, L2778F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I, T2537I; ORF3a: D27H, A54V, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBU","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBU"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","A3620V","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, A3620V, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBS","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBS"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T670G","C2790T","C2842T","C3037T","C3796T","C3809T","C3927T","G4184A","C4321T","C4586T","C5183T","C6982T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","T20748C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["G82-","H83-","V84-","M85V","S135R","T842I","L1182F","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: G82-, H83-, V84-, M85V, S135R, T842I, L1182F, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBT","node_attrs":{"div":81,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5037920175803539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C829T","C1627T","C2790T","C3037T","A3207G","G4184A","G4288A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","G23587A","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","D981G","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, D981G, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBV","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBV"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8040G","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","G15957T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123A","A23223G","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24170G","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","D2592G","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","T1050N","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","P521T","E554G","D614G","H655Y","N679K","P681H","N764K","D796Y","I870V","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, D2592G, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, T1050N, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K"}}},{"name":"XBW","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBW"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22612C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","G29260A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBY","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBY"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5812T","C9344T","A9424G","C9532T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","G19962T","A20055G","C21054T","G21305A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T28137A","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I","R2613H"],"ORF3a":["T223I"],"ORF8":["S82T"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I, R2613H; ORF3a: T223I; ORF8: S82T; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBZ","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBZ"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","T2954C","C3037T","G4184A","C4321T","C6040T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","C12880T","T14257C","C14408T","C15714T","G16935A","A17039G","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T21992-","A21993-","T21994-","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22858T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23086T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26428T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","C28770T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","V62F"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","T166I","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["Y264H","P314L","M1156I","N1191S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","Y144-","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, V62F; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, T166I, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: Y264H, P314L, M1156I, N1191S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XC","node_attrs":{"div":39,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XC"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5239T","T5514C","C6402T","C7124T","C8986T","G9053T","C10029T","A11201G","A11332G","C14408T","G15451A","C16466T","C19220T","C21618G","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22081T","T22917G","C22995A","A23403G","C23604G","G24410A","C25469T","T26767C","G27390T","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"M":["I82T"],"N":["D3L","R203K","G204R","S235F"],"ORF1a":["A1306S","V1750A","P2046L","P2287S","V2930L","T3255I","T3646A"],"ORF1b":["P314L","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","Y73C"],"S":["I19R","T95I","G142D","E156-","F157-","R158G","Q173H","L452R","T478K","D614G","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D3L, R203K, G204R, S235F; ORF1a: A1306S, V1750A, P2046L, P2287S, V2930L, T3255I, T3646A; ORF1b: P314L, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF8: Q27*, R52I, Y73C; S: I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N","spike_mutations":"I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N"}}},{"name":"XCC","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCC"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1545T","C2790T","C3037T","C3796T","C3857A","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A427V","T842I","Q1198K","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A427V, T842I, Q1198K, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCA","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCA"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2062T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C5748A","C9344T","A9424G","T9454C","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19017T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21893A","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","C22747T","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","C23595T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","T25975C","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","T1828N","L3027F","T3090I","L3201F","T3255I","P3395H","A3620V","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["S195P","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","D111N","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","T678I","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, T1828N, L3027F, T3090I, L3201F, T3255I, P3395H, A3620V, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: S195P, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCB","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCB"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","A11126G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C12880T","C14408T","C14724T","C15714T","C17410T","A18163G","G18651A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22302-","T22303-","T22304-","T22348A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27600T","C27807T","C27889T","A28271T","T28282C","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","M3621V","S3675-","G3676-","F3677-","A4016T"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","S247-","Y248N","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, M3621V, S3675-, G3676-, F3677-, A4016T; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCE","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1931A","C2790T","T2954C","C3037T","G4184A","C4321T","C9344T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15810T","T15939C","T16342C","C17410T","T17859C","A18163G","G18811A","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","Q556K","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","D1782N","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","Y200C","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, Q556K, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, D1782N, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCD","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCD"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-08"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18006C","A18163G","A19173G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22203A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","G28077T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28681T","G28881A","G28882A","G28883C","C29367T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","P365L","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","R214H","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, P365L, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF8: V62L; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCG","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8170G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCJ","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCJ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C1063T","C2790T","C3037T","G4184A","C4321T","C6312T","A6616G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22843C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27431T","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28770T","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","T166I","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","T2016I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["A13V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","G181R","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, T166I, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, T2016I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: A13V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCK","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCK"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","T2128C","C2790T","C3037T","G3242A","G4184A","C4321T","C5512T","G5720A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12880T","C12970T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18096C","A18163G","A19326G","C19955T","G19962T","A20055G","G20060T","A21137G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","C26270T","G26529A","C26577G","G26709A","G26951C","C27807T","C27889T","C28163A","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","T29726-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G993S","G1307S","G1819S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I","S2198I","K2557R"],"ORF3a":["T223I","V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G993S, G1307S, G1819S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I, S2198I, K2557R; ORF3a: T223I, V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XCL","node_attrs":{"div":101,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C7417T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15755G","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23093A","A23403G","C23525T","T23599G","C23604A","C23741T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25046T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S763C","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","V511I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","P1162S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S763C, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S"}}},{"name":"XCN","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCN"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C337T","T670G","C1142T","C1471T","C1513T","C1686T","T2372C","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7318T","C8782T","G8849A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C14408T","C14790T","T14961C","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21807A","C21910T","G21987A","A22001G","T22016C","C22033A","A22121G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","T23332C","A23403G","C23453T","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27635T","C27807T","G27915T","C28253T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","L293F","A474V","T842I","S1221L","G1307S","P1640S","V2862M","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","P82H","G142D","K147E","W152R","F157L","K187E","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","P631S","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, L293F, A474V, T842I, S1221L, G1307S, P1640S, V2862M, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: S81L; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCM","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","G331T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","C5730T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T13560C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17661C","T17859C","A18163G","A18879G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24134A","A24373G","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","A29558G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["Q22H","K47R","S135R","T842I","G1307S","T1822I","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["A72T","A110V","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","F157L","N185D","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: Q22H, K47R, S135R, T842I, G1307S, T1822I, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: A72T, A110V, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}}},{"name":"XCP","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCP"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","C3622T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","C12880T","C14408T","A14634G","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","C19185T","A19326G","C19488T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","I3758V","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, I3758V, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCQ","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","A13187G","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","A22320G","C22388T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23757T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","I4308V"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","T732I","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, I4308V; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K"}}},{"name":"XCR","node_attrs":{"div":106,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCR"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C13405T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24373C","A24424T","T24469A","C25000T","A25359G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26708G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K","K1266R"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R"}}},{"name":"XCS","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCS"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17010T","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27669G","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","A29221G","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K"}}},{"name":"XCU","node_attrs":{"div":99,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCU"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1437T","C2790T","C3037T","T3478C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","C9891T","C10029T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","A17207G","A19890G","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","T23042C","A23055G","A23063T","T23075C","C23123A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","C26606T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28376A","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","A35T","R203K","G204R","S413R"],"ORF1a":["S135R","S391F","T842I","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","A3209V","T3255I","V3718A","T3750I"],"ORF1b":["P314L","G662S","P1000L","T1050I","Y1247C"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","D215H","A222V","L242-","A243-","S256L","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","S494P","Q498R","N501Y","Y505H","P521T","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, A35T, R203K, G204R, S413R; ORF1a: S135R, S391F, T842I, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, A3209V, T3255I, V3718A, T3750I; ORF1b: P314L, G662S, P1000L, T1050I, Y1247C; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCV","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCV"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","T5422C","C7044A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27065A","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28182G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","P2260H","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, P2260H, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, S97G; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCY","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCY"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCW","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCW"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","T6394C","G6536A","G8863T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T14305C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","G18636A","T18882C","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27513T","C27684T","C27807T","G27915T","T28034C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["Y280H","P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","I210-","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: Y280H, P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCZ","node_attrs":{"div":112,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCZ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","A15436G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22609G","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26735T","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28519T","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","M657V","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-","T79I"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, M657V, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-, T79I; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XD","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.029110000000000004"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XD"},"totalAminoacidDeletions":{"value":5},"immune_escape":{"value":"0.17203353628663032"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","A1321C","C3037T","G4181T","C6402T","C7124T","C7851T","A8723G","C8986T","G9053T","C10029T","A11201G","A11332G","C14407T","C14408T","T15264C","G15451A","C16466T","C19220T","C21618G","G21641T","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25667T","G25855T","T26767C","T27638C","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G28916T","G29402T","G29540A","G29645T","G29742T"],"M":["I82T"],"N":["D63G","R203M","G215C","D377Y"],"ORF1a":["E352D","A1306S","P2046L","P2287S","A2529V","I2820V","V2930L","T3255I","T3646A"],"ORF1b":["P314F","G662S","P1000L","A1918V"],"ORF3a":["S92L","D155Y"],"ORF6":["L61D"],"ORF7a":["V82A","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["I19R","A27S","T95I","G142D","E156-","F157-","R158G","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"M: I82T; N: D63G, R203M, G215C, D377Y; ORF1a: E352D, A1306S, P2046L, P2287S, A2529V, I2820V, V2930L, T3255I, T3646A; ORF1b: P314F, G662S, P1000L, A1918V; ORF3a: S92L, D155Y; ORF6: L61D; ORF7a: V82A, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: T60A; S: I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XDB","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","G15982A","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["P314L","G662S","V839I","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: P314L, G662S, V839I, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDC","node_attrs":{"div":108,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDC"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2110T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","C15763T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21036T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDE","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","T21363C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26612G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29535T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","S302F","T842I","G1307S","P2079Q","T2283I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","P4220L"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, S302F, T842I, G1307S, P2079Q, T2283I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, P4220L; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDF","node_attrs":{"div":107,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C335T","A405G","T670G","C2790T","C3037T","T3453C","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","G27666T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","T28382C","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","S37P","R203K","G204R","S413R"],"ORF1a":["R24C","K47R","S135R","T842I","V1063A","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, S37P, R203K, G204R, S413R; ORF1a: R24C, K47R, S135R, T842I, V1063A, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: E91D; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDG","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C547T","T670G","C1758T","C2790T","C3037T","G4184A","C4321T","T4579A","T4690C","T4930C","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","T16905C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","A23598G","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","A25744G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28754T","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","L161F","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A498V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["I118V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679R","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, L161F, R203K, G204R, S413R; ORF1a: K47R, S135R, A498V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: I118V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDH","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDH"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","T2992A","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","T4744C","C5183T","T7477C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C13335T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","D909E","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S","A4357V"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, D909E, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S, A4357V; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDJ","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDJ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C8947T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","A10861G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G29081T","A29510C","C29625T","A29700G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","V270L","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","F157L","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, V270L, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDL","node_attrs":{"div":110,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2650T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","C17410T","T17859C","C17976T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","T24903C","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","C28253A","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","F120L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","I1114T"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, F120L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T"}}},{"name":"XDM","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","T24046C","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","D335G","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["T76A","P314L","G662S","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, D335G, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: T76A, P314L, G662S, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDN","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDN"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","C280T","T670G","C897A","C1762A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","C12880T","T13339C","C14408T","C14425T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","F499L","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, F499L, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K"}}},{"name":"XDS","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDS"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","G598A","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29409T","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","C29836T"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","T379I","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, T379I, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDT","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDT"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C1601T","C2790T","C3037T","G3431T","G4184A","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9344T","A9424G","C9534T","C9661T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","T25496C","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27014A","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29778A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","L446F","T842I","V1056L","G1307S","N2526S","A2710T","I2790V","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","V3892A","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["I35T","T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","H69-","V70-","V127F","G142D","Y144-","R158G","N211-","L212I","V213G","L216F","A222V","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, L446F, T842I, V1056L, G1307S, N2526S, A2710T, I2790V, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, V3892A, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: I35T, T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}}},{"name":"XDU","node_attrs":{"div":111,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDU"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.9475349114594978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","C3177T","C3587T","C3944A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","C22674T","T22679C","C22686T","A22688G","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26078T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","P971L","H1108Y","Q1227K","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I","T229I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","S371F","S373P","S375F","T376A","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, P971L, H1108Y, Q1227K, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I, T229I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDW","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDW"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","T1030C","A2127G","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14120T","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21301T","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","Y621C","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P218L","P314L","R1315C","I1566V","T2163I","P2612S"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A263V","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, Y621C, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P218L, P314L, R1315C, I1566V, T2163I, P2612S; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XDZ","node_attrs":{"div":114,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDZ"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7086T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","C23557T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","T2274I","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, T2274I, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDY","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDY"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","G19669A","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","C22858T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","G2068R","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, G2068R, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XE","node_attrs":{"div":62,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C14599T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XEA","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEA"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2268340125514634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","C13255T","T13339C","A13712G","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","D1513E","K1973R","N2526S","A2529S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["K82R","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, D1513E, K1973R, N2526S, A2529S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: K82R, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEB","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEB"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XED","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XED"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":17.361},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XED"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9430T","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","A13308G","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25350T","C25584T","C26060T","C26270T","G26529C","C26577G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","T170I","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I","K4348R"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L","P1263L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, T170I, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I, K4348R; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L"}}},{"name":"XEG","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEG"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":950.694},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEG"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","A2443G","C2790T","C2939T","C3037T","C3876T","G4184A","C4234T","C4321T","G6536A","A6646G","T6747C","C7819G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T10723C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","G19327T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","C23191T","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","P892S","A1204V","G1307S","G2091S","L2161S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","A1954S","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, P892S, A1204V, G1307S, G2091S, L2161S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, A1954S, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEE","node_attrs":{"div":125,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEE"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEE"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.013909339904785}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","G17334T","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","T2121A","T2283I","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","H146Q","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, T2121A, T2283I, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XEF","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEF"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":34.028},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEF"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7268345560655398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","G4255T","C4321T","C4683T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","A1473V","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","N211-","L212I","V213G","L216F","H245N","A264D","I332V","L335S","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, A1473V, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XG"},"totalAminoacidDeletions":{"value":9},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","T5386G","C5672T","G5924A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19855G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","P1803S","V1887I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","I2130V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, P1803S, V1887I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, I2130V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XH","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XH"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.385257720947266}},"branch_attrs":{"mutations":{"nuc":["C241T","T902C","C904A","G1244A","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28435T","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["C213R","G327S","K856R","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-","P51L"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: C213R, G327S, K856R, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-, P51L; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XF","node_attrs":{"div":57,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XF"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.623017311096191}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","T1390C","A2255G","C3037T","G4181T","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29632T"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["I664V","A1306S","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: I664V, A1306S, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XJ","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XJ"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","G11287-","T11288-","C11289-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675F","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675F, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XK","node_attrs":{"div":59,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XK"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":45},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A16064G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23403G","C23525T","T23599G","C23604A","A23767G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","R1628C","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","Q866R","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, R1628C, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, Q866R, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XL","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","C875T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G14229A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["L204F","K856R","V1887I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: L204F, K856R, V1887I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XM","node_attrs":{"div":60,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-31"},"totalAminoacidSubstitutions":{"value":46},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.202030658721924}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XN","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XN"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.321341514587402}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","G10986A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","R3574K","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, R3574K, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XP","node_attrs":{"div":59,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XP"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3616394203564539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.596989154815674}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24190C","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","C26880A","A27259C","C27807T","A28254-","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3G","Q19E","A63T","L120I"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF8":["I121-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T, L120I; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF8: I121-; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XQ","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XQ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.557485103607178}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A17615G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","K1383R","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, K1383R, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XR","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C4893T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G13295A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25524G","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","C27131T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","T1543I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","D4344N"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, T1543I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, D4344N; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XS","node_attrs":{"div":61,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XS"},"totalAminoacidDeletions":{"value":14},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.812867641448975}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5365T","C6196T","C6402T","C7124T","C8986T","G9053T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21595T","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["A1306S","P2046L","P2287S","V2930L","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: A1306S, P2046L, P2287S, V2930L, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XU","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XU"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C16887T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XT","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.945826530456543}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13994T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21786T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["A176V","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G75V","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: A176V, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XV","node_attrs":{"div":62,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XV"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.5818281173706055}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3583T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XW","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XW"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-12"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","C10507T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12756T","C12880T","C14408T","C15714T","G16020T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-","T4164I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-, T4164I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XY","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XY"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A1585G","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11049C","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","A22351G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26058T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","V3595A","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, V3595A, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XZ","node_attrs":{"div":64,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XZ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.045060634613037}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","G20398A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I","E2311K"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I, E2311K; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"internal_XBK","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBK.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","A1124G","C1973T","A2163C","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16856G","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","G25947C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27741T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R287G","E633A","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","D1130G","R1315C","I1566V","T2163I"],"ORF3a":["Q185H","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R287G, E633A, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, D1130G, R1315C, I1566V, T2163I; ORF3a: Q185H, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCH.1","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1684T","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7051T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19886G","C19955T","A20055G","C20320T","A20741G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22115G","A22190G","T22200G","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","T24073C","C24134A","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","K2140R","T2163I","H2285Y","Q2425R"],"ORF3a":["A72T","A110V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","N185D","I210V","V213G","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, K2140R, T2163I, H2285Y, Q2425R; ORF3a: A72T, A110V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}},"children":[{"name":"XCT.1","node_attrs":{"div":111,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","D335G","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["T76A","P314L","G662S","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, D335G, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: T76A, P314L, G662S, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDA.1","node_attrs":{"div":108,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18657T","C18894T","C19716T","C19955T","A20055G","C21618T","C21622T","G21624C","C21627A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25006T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28291A","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G28884C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204P","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P3H","P10S","E27-","N28-","A29-"],"S":["R21T","T22N","L24-","P25-","P26-","A27S","S50L","F59S","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204P, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P3H, P10S, E27-, N28-, A29-; S: R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":133,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":29.34},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-14"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":34.028},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4006A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17067C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","T26012G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["F207C","T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: F207C, T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCF","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T170I","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T170I, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2668T","C2790T","C3037T","G4184A","C4321T","C6896T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.1","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G3446A","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","A20379G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","A1061T","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, A1061T, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBL","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.1","node_attrs":{"div":99,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"XBL.2","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"NODE_0000016","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","C7420T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A27980G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","T29023C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDQ","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":114,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.493660926818848}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.296816825866699}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1.1","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDQ.1","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.296816825866699}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1471T","C2445T","C2790T","C3037T","G3072A","G4184A","C4321T","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10189T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C12880T","C14408T","C15714T","C17410T","C17678T","A18163G","C18252T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22020C","T22054G","T22200G","C22295A","G22332A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893G","A22910G","C22916A","T22942G","G22992A","C22995A","G23012A","A23013G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25896T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T727I","T842I","C936Y","G1307S","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","Q3922R"],"ORF1b":["P314L","R1315C","T1404M","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","M153T","N164K","V213G","H245N","G257D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444R","N450D","L452M","N460K","S477N","T478K","E484R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T727I, T842I, C936Y, G1307S, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, Q3922R; ORF1b: P314L, R1315C, T1404M, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBJ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000021","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBJ.1.1","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.2","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"XDD.3","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"NODE_0000025","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","C23277T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","T572I","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.2","node_attrs":{"div":125,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","C22928T","A23598G","C27297T"],"S":["L456F","K679R"]},"labels":{"aa":"S: L456F, K679R","spike_mutations":"L456F, K679R"}}},{"name":"XDK.3","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.635818004608154}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"internal_0964eaa1","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"XDK.4.1","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S"}}}]},{"name":"internal_C29762T","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":126,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, Q1201K","spike_mutations":"R237K, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G11596A","C18664T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.2","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.803860664367676}},"branch_attrs":{"mutations":{"nuc":["G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"NODE_0000032","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}},"children":[{"name":"XDK.1","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.1","node_attrs":{"div":129,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","T18664C","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["C241T","G625T","T670G","C1627T","C2790T","C3037T","T3339C","G4184A","C4321T","C6070T","C8692T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K120N","S135R","T842I","V1025A","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K120N, S135R, T842I, V1025A, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBF","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000034","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.2","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.10","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.3","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.5","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.6","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.9","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000035","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000036","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000037","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C12880T","C14408T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","A21623G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23423T","C23525T","T23599G","C23604A","C23679T","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","C26681T","T26767C","G26959A","C27575G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"M":["I82T","R146H"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","P2287S","T2777I","V2930L","T3255I","P3395H","S3675-","G3676-","F3677-","T4161I"],"ORF1b":["P314L","A520V","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["T61S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L18F","I19R","R21G","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","P621S","H655Y","N679K","P681H","A706V","N764K","D796Y","Q954H","N969K","T1117I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, P2287S, T2777I, V2930L, T3255I, P3395H, S3675-, G3676-, F3677-, T4161I; ORF1b: P314L, A520V, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF7a: T61S; ORF9b: P10S, E27-, N28-, A29-; S: L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I","spike_mutations":"L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000039","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000040","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.996061325073242}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.996061325073242}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000041","node_attrs":{"div":81,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15492057800293}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000217437744141}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000042","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15492057800293}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796271324157715}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.6994194984436035}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000043","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.522014617919922}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.522014617919922}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000044","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000045","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097011089324951}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000046","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.778554439544678}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000047","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.697335243225098}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752889267417711"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.495386123657227}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":95,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","S302F","T842I","G1307S","P2079Q","T2283I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","P4220L"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, S302F, T842I, G1307S, P2079Q, T2283I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, P4220L; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000049","node_attrs":{"div":119,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1.1","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":125,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.10"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1","node_attrs":{"div":119,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.11","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.11"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.6","node_attrs":{"div":126,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.4","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.5","node_attrs":{"div":124,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.14808999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5359962252743784"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.8","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000050","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2.1","node_attrs":{"div":127,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":6.25},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.26874999999999993"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.8051577060608006"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}},{"name":"XDV.1.2","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.3181399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000051","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":126,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000052","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":123,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20783000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5422010449483097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","C9891T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23670T","C23854A","G23948T","A24424T","T24469A","C25000T","C25854T","T26767C","T26819C","T27718C","C27752T","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1a":["S135R","T842I","T1543I","P1640L","S2104I","V2276I","A3209V","V3718A","T3750I"],"ORF1b":["P314L","G662S","P1000L","T1050I"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["T60A"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","P209L","L212S","D215H","A222V","L242-","A243-","S256L","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N703I","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1a: S135R, T842I, T1543I, P1640L, S2104I, V2276I, A3209V, V3718A, T3750I; ORF1b: P314L, G662S, P1000L, T1050I; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: T60A; S: P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000054","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000055","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":72,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"recombinant"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"ace2_binding":{"value":"0.6871599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"partiallyAliased":{"value":"XBC.2"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.2.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.44507236664312827"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000056","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"recombinant"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"partiallyAliased":{"value":"XBC.1"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000057","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.4"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":74,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.5"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.2.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000059","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000060","node_attrs":{"div":78,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}},{"name":"XBC.1.1.1","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.48837241784414276"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}}]}]},{"name":"NODE_0000061","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000062","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000063","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.1","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.4","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}},{"name":"KD.3","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}}]}]}]},{"name":"NODE_0000065","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.4"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.5"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000066","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000067","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"JT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7550301657183831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.6"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":85,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":85,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000069","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.7420325830319254"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}},{"name":"HW.1.2","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","clade":"22F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBB","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000071","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000072","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000073","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.3064099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.26627999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0810114368008295"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000074","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000075","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}},{"name":"XBB.8.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122063159942627}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122063159942627}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.5","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1652350425720215}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.256869792938232}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"NODE_0000081","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143524169922}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XBB.2.11.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}},{"name":"XBB.2.11","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143524169922}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000082","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65097"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.832684516906738}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"internal_d796","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":96,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":96,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.0750199999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2567103717994188"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.21","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.20","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.5","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.456076145172119}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84789"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0527558336884004"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.90647"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.901963710784912}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89932"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736186906064397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.7709600000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0079043361863298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000102","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000103","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.607783317565918}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bb69915a","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.2","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.70075"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.986824739722089"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":111,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":111,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":112,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":114,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":114,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.203644752502441}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.6","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":115,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.062752723693848}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1.10","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13558"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.062752723693848}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.3","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.49564"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0545"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.33"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-18"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.89405"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.49"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54201602935791}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.9722600000000003"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.48"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"GW.4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"XBB.1.19.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000141","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":114,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":116,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":116,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":121,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.1","node_attrs":{"div":121,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.3","node_attrs":{"div":118,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1269190311431885}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86729"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.2602599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.88502836227417}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-09"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000148","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.37.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_234859ae","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306640625}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306640625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000155","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-20"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296722412109375}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.751910209655762}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.072850704193115}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.578298091888428}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.05231"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"FW.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.09468412399292}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"XBB.1.28.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":106,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FP.4","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"XBB.1.11.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.7388600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296722412109375}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.46"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.05408"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000173","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000176","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"NODE_0000177","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.4","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.5","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FE.1.1.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"NODE_0000178","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6066099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1099290580037755"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.4","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}},{"name":"JC.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.43418"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"XBB.1.17","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000188","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10.1","node_attrs":{"div":111,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-03"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.10","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}},{"name":"GA.6","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000192","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.96117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000194","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80721"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000195","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}},{"name":"GA.7.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.90647"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000196","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":109,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":109,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.2","node_attrs":{"div":113,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}},{"name":"GA.4.1.3","node_attrs":{"div":112,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":92,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":92,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.110"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.110"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.43"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.45"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.57","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.57"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.58"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.87"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8739418983459473}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8739418983459473}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2760300636291504}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.101"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.101"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.104"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.104"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.082747936248779}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.105"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.105"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.108","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.108"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.108"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.109","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.109"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.109"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.960801124572754}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.64321231842041}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.734973192214966}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.002401351928711}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8424923419952393}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.41404999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.887559652328491}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.28225564956665}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.33","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.639432430267334}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.35","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.06293249130249}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.36","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.254280090332031}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.95377"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184874534606934}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.52","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.52"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.847869634628296}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.54"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.51","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.51"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.59","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.59"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.106780052185059}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.62"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.189829349517822}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.63"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7503247261047363}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.64"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.169807434082031}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.67"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.767808198928833}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.66"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.69","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.69"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266829013824463}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.75"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.79"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.65611457824707}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.80"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.27465295791626}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.91194"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.82"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.85"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9143218994140625}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.97"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.97"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.98","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.98"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.98"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.99"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.99"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"NODE_0000202","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.174046039581299}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762267112731934}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.809103012084961}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762267112731934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.29094"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1023732112409157"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.41123000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.282760143280029}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7288198471069336}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850557327270508}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7288198471069336}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.50"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.48403999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.71"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9061"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.03073601411565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.989252090454102}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2972187995910645}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2972187995910645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.091251373291016}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.7416800000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.73864"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.99921178817749}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.1186099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.511922359466553}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5768063068389893}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.3","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"EK.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9873000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0346353162114479"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.174569606781006}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.5.13","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5768063068389893}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.3","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.345157623291016}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.842705726623535}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.345157623291016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.3","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.4","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":114,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000241","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":108,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.20635"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2868306565498102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000244","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376531600952}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.1","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.4","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.3","node_attrs":{"div":108,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.1261900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3046787170970133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.7","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}},{"name":"JD.1.1.5","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.6","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":103,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.7","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.6","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.9","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":103,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"GK.3.1","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.4253100000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.3","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.2","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.4","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.4","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.7","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":118,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.6.1","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_34743931","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":119,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000259","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1.1","node_attrs":{"div":118,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.1446400000000003"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3541583181563797"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"KN.1","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.4131407737731934}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.106"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.106"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6764075756073}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.187679767608643}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.515899181365967}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.674118757247925}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0984206199646}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.56"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.201076984405518}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.60"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.624792575836182}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.61"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265189170837402}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.65"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8305227756500244}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.74","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9630099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.74"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0169257119491577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.72","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.72"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.78","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.78"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.76","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.76"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.102418422698975}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.8","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.449069023132324}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.81","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.81"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.6281256675720215}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.83","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.83"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.545154094696045}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.84"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.84"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.25019645690918}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.88"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.88"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.298462867736816}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.89","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.89"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.89"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.91","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.91"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.91"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.224147796630859}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.90"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.90"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.96","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.96"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.96"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.1118998527526855}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"XBB.1.5.94","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.94"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.94"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"NODE_0000263","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.83085"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.83156"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9838451476656441"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.13517951965332}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9350799999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"GB.2","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.46","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"HR.1.1","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.816847085952759}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.310755729675293}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"HT.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"XBB.1.5.49","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.816847085952759}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1.1","node_attrs":{"div":109,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}},{"name":"JB.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000274","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}},{"name":"JB.2","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.74638"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0924169334128189"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.89299"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1.1","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}},{"name":"FD.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}},{"name":"FD.2","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}},{"name":"FD.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000283","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]}]}]}]}]},{"name":"NODE_0000284","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.78204870223999}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.561348915100098}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.214216709136963}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.214216709136963}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86018"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.950188045949472"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.67693"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9788766097021935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}},{"name":"FY.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_87efaafa","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388861656188965}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8926499999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"NODE_0000297","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3936004638671875}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3936004638671875}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":106,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}}]},{"name":"internal_6436aedc","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"FY.1.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000305","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":101,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.99566912651062}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":101,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.99566912651062}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.181058645248413}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.10","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.14","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.7388600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.21","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.23","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.25","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.24","node_attrs":{"div":111,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.26","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.182722091674805}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.27","node_attrs":{"div":116,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000307","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":114,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"KJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.1","node_attrs":{"div":110,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"JM.2","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"XBB.1.16.15","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.1","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"HF.1.2","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121835708618164}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000315","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.2","node_attrs":{"div":110,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1.1","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}},{"name":"JF.1.1","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"2.14642"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}},{"name":"FU.3.1","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}}]},{"name":"NODE_0000319","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.4","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8164899999999998"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.3","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.5","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.8","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.7","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.9","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":115,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0967888832092285}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.42","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000327","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":93,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":93,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":94,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.6","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.13558"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"XBB.1.9.5","node_attrs":{"div":94,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"NODE_0000329","node_attrs":{"div":95,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.331241607666016}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":95,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":96,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927204608917236}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.064053058624268}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.2342681884765625}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.532744884490967}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.29","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.7904599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.27","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.34","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.2174906730651855}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.6","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.7","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"FL.8","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"XBB.1.9.1","node_attrs":{"div":96,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927204608917236}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000331","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0848"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9957660361777405"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}},{"name":"FL.31","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000336","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.516284465789795}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.919839382171631}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}},{"name":"FL.39","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000340","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.5920999999999998"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.2","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.98073"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1216394663867173"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10.3","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000347","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.96117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8835"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.2","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.4","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.5","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"totalAminoacidDeletions":{"value":35},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_10382b90","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_59305500","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.67327356338501}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_24b5ee08","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000358","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000359","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000361","node_attrs":{"div":111,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":114,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":113,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]}]},{"name":"NODE_0000362","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.6712799072265625}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.4","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"internal_fc124546","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"FL.2.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000366","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4584245681762695}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.93509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.3348299999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.4.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.48144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0186868047371063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000369","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.6","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}},{"name":"FL.4.5","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.3","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.8","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"FL.1.7","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"internal_18deba5f","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.89211"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9778643306477401"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5381855964660645}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5381855964660645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000374","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.06800999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000375","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}},{"name":"KC.1.1","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}}]}]},{"name":"NODE_0000376","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000377","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4.2","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HN.4","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000378","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":115,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.0007299999999998658"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005141566416802"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000379","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232717037200928}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000380","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000381","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000382","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.6197006702423096}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.12","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.13","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.11","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.14","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.7","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1186099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.6197006702423096}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}},{"name":"EG.9","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.20938"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}}]},{"name":"internal_16d15670","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}},{"name":"EG.10.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000387","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000388","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.3","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}},{"name":"EG.2.5","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.2","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.2","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}},{"name":"EG.4.5","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000391","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.3","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.5","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.6","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"EG.1.7","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"internal_e85bc240","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4.1","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}},{"name":"EG.1.4","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173667907715}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"internal_cc5f07eb","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"NODE_0000395","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000396","node_attrs":{"div":104,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":104,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.13","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.16","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.18","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.19","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.2","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.5","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000400","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.73257"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4312755323086508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-29"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000401","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000402","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{}}},{"name":"JG.2","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.1","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.4","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000404","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.2","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.4253100000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.4","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"JG.3.3","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}}]}]},{"name":"NODE_0000405","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000406","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1.10","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.025979999999999802"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.0887599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3341105633249508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.4","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.3","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.21974"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005451981781486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.7","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.8","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"internal_2378868c","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.048559999999999943"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.38161000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3552393372267753"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000408","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000410","node_attrs":{"div":115,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":115,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":118,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000411","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.19","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.17","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.13706999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1972306507819483"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.21","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.1481699999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.205901853206978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":117,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.49366"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.310148541751831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":125,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-27"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.29","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.28","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.30","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.32","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.31","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.4","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.6088199999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2183176254438959"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000418","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":119,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.48614000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3534097328298118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000422","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":117,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"NODE_0000426","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":116,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.15","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.14","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":108,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_membership":{"value":"23H"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":108,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":109,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.10","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":112,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.13","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":112,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.5","node_attrs":{"div":114,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.4","node_attrs":{"div":113,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.9","node_attrs":{"div":113,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"HK.3.7","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"internal_ca7dc568","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_membership":{"value":"23H"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":117,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":118,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000431","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.23","node_attrs":{"div":2,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.23"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.23"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.469736099243164}},"branch_attrs":{"mutations":{"nuc":["A1605-","T1606-","G1607-","C20270T","C29870A"],"ORF1a":["D448-"],"ORF1b":["A2268V"]},"labels":{"aa":"ORF1a: D448-; ORF1b: A2268V"}}},{"name":"B.3","node_attrs":{"div":2,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.0303568840026855}},"branch_attrs":{"mutations":{"nuc":["G1440A","G2891A"],"ORF1a":["G392D","A876T"]},"labels":{"aa":"ORF1a: G392D, A876T"}}},{"name":"B.55","node_attrs":{"div":1,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.55"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":0},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.333273410797119}},"branch_attrs":{"mutations":{"nuc":["T514C"]}}},{"name":"internal_f40a","node_attrs":{"div":1,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.376053333282471}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"B.4","node_attrs":{"div":4,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.114970684051514}},"branch_attrs":{"mutations":{"nuc":["G1397A","T28688C","G29742T"],"ORF1a":["V378I"]},"labels":{"aa":"ORF1a: V378I"}}},{"name":"NODE_0000433","node_attrs":{"div":3,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.597896099090576}},"branch_attrs":{"mutations":{"nuc":["C14805T","G26144T"],"ORF3a":["G251V"]},"labels":{"aa":"ORF3a: G251V"}},"children":[{"name":"B.39","node_attrs":{"div":6,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.39"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["A1515G","C9223T","T17247C"],"ORF1a":["H417R"]},"labels":{"aa":"ORF1a: H417R"}}},{"name":"B.40","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.40"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.40"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.6938891410827637}},"branch_attrs":{"mutations":{"nuc":["A2480G","C2558T"],"ORF1a":["I739V","P765S"]},"labels":{"aa":"ORF1a: I739V, P765S"}}}]},{"name":"NODE_0000434","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{"nuc":["C6312A","C13730T","C23929T","C28311T"],"N":["P13L"],"ORF1a":["T2016K"],"ORF1b":["A88V"],"ORF9b":["P10S"]},"labels":{"aa":"N: P13L; ORF1a: T2016K; ORF1b: A88V; ORF9b: P10S"}},"children":[{"name":"B.6.6","node_attrs":{"div":7,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6.6"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.6.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.402256011962891}},"branch_attrs":{"mutations":{"nuc":["C6310A","C19524T"],"ORF1a":["S2015R"]},"labels":{"aa":"ORF1a: S2015R"}}},{"name":"B.6","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000435","node_attrs":{"div":3,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.371640682220459}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S","clade":"19B"}},"children":[{"name":"A","node_attrs":{"div":3,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.371640682220459}},"branch_attrs":{"mutations":{}}},{"name":"A.1","node_attrs":{"div":6,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-3.6224653720855713}},"branch_attrs":{"mutations":{"nuc":["C17747T","A17858G","C18060T"],"ORF1b":["P1427L","Y1464C"]},"labels":{"aa":"ORF1b: P1427L, Y1464C"}}},{"name":"A.5","node_attrs":{"div":4,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.451473712921143}},"branch_attrs":{"mutations":{"nuc":["C26088T"]}}},{"name":"A.3","node_attrs":{"div":13,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.0400519371032715}},"branch_attrs":{"mutations":{"nuc":["T490A","C3177T","C6040T","G12478A","T18736C","C24034T","T26729C","G28077C","C28896G","A29700G"],"N":["A208G"],"ORF1a":["D75E","P971L","M4071I"],"ORF1b":["F1757L"],"ORF8":["V62L"]},"labels":{"aa":"N: A208G; ORF1a: D75E, P971L, M4071I; ORF1b: F1757L; ORF8: V62L"}}},{"name":"NODE_0000436","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["T9477A","C14805T","G25979T","C28657T","C28863T"],"N":["S197L"],"ORF1a":["F3071Y"],"ORF3a":["G196V"]},"labels":{"aa":"N: S197L; ORF1a: F3071Y; ORF3a: G196V"}},"children":[{"name":"A.2","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000437","node_attrs":{"div":27,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{"nuc":["C275T","C1567T","C4543T","A5234G","A5488G","C10029T","C11005A","C12815T","C16466T","T16857C","T18417C","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T22917G","A23403G","G24697A","C25613T","C26681T","A28272T","G28975T","C29421T"],"N":["M234I","P383L"],"ORF1a":["L4F","K1657E","T3255I","H3580Q"],"ORF1b":["P1000L"],"ORF3a":["S74F"],"S":["L141-","G142-","V143-","L452R","D614G"]},"labels":{"aa":"N: M234I, P383L; ORF1a: L4F, K1657E, T3255I, H3580Q; ORF1b: P1000L; ORF3a: S74F; S: L141-, G142-, V143-, L452R, D614G","spike_mutations":"L141-, G142-, V143-, L452R, D614G"}},"children":[{"name":"A.2.5","node_attrs":{"div":27,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{}}},{"name":"A.2.5.1","node_attrs":{"div":29,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.277773380279541}},"branch_attrs":{"mutations":{"nuc":["C1722T","C29366T"],"N":["P365S"],"ORF1a":["A486V"]},"labels":{"aa":"N: P365S; ORF1a: A486V"}}},{"name":"A.2.5.2","node_attrs":{"div":30,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.2"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.212984561920166}},"branch_attrs":{"mutations":{"nuc":["T15326C","A22525G","G27706T"],"ORF1b":["M620T"],"ORF7a":["A105S"]},"labels":{"aa":"ORF1b: M620T; ORF7a: A105S"}}},{"name":"A.2.5.3","node_attrs":{"div":30,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-04"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["G2272A","G22992A","C29870A"],"S":["S477N"]},"labels":{"aa":"S: S477N","spike_mutations":"S477N"}}}]}]},{"name":"NODE_0000438","node_attrs":{"div":5,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.395697593688965}},"branch_attrs":{"mutations":{"nuc":["G28878A","G29742A"],"N":["S202N"]},"labels":{"aa":"N: S202N"}},"children":[{"name":"A.18","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.221602916717529}},"branch_attrs":{"mutations":{"nuc":["A3234T","C15126T","A23403G","C27812T"],"ORF1a":["Q990L"],"S":["D614G"]},"labels":{"aa":"ORF1a: Q990L; S: D614G","spike_mutations":"D614G"}}},{"name":"A.21","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.21"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.21"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C10138T","G11417T","G23402A","G25687T"],"ORF1a":["V3718F"],"ORF3a":["A99S"],"S":["D614N"]},"labels":{"aa":"ORF1a: V3718F; ORF3a: A99S; S: D614N","spike_mutations":"D614N"}}},{"name":"NODE_0000439","node_attrs":{"div":6,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.657860279083252}},"branch_attrs":{"mutations":{"nuc":["G22468T"]}},"children":[{"name":"A.28","node_attrs":{"div":20,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.28"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-18"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A481G","G521T","C2197T","G10850A","C12469T","C16391T","G17014T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A23064C","C23525T","C25904T","C27294T","A27489G","A28272T","C28377T"],"N":["A35V"],"ORF1a":["V86F","A3529T"],"ORF1b":["A975V","D1183Y"],"ORF3a":["S171L"],"ORF9b":["R32C"],"S":["H69-","V70-","N501T","H655Y"]},"labels":{"aa":"N: A35V; ORF1a: V86F, A3529T; ORF1b: A975V, D1183Y; ORF3a: S171L; ORF9b: R32C; S: H69-, V70-, N501T, H655Y","spike_mutations":"H69-, V70-, N501T, H655Y"}}},{"name":"NODE_0000440","node_attrs":{"div":7,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A361G"]}},"children":[{"name":"A.19","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.19"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.19"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12820G","A23403G"],"S":["D614G"]},"labels":{"aa":"S: D614G","spike_mutations":"D614G"}}},{"name":"A.27","node_attrs":{"div":24,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.27"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-18"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C1122T","C2509T","A9204G","A11217G","C16466T","A18366G","A20262G","C21614T","T22917G","A23063T","C23520T","C23525T","G23948T","G25218T","T25541C","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","C27247T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28273T"],"ORF1a":["P286L","D2980G","N3651S"],"ORF1b":["P1000L"],"ORF3a":["V50A","N257-","P258-"],"ORF8":["D119-","F120-"],"S":["L18F","L452R","N501Y","A653V","H655Y","D796Y","G1219V"]},"labels":{"aa":"ORF1a: P286L, D2980G, N3651S; ORF1b: P1000L; ORF3a: V50A, N257-, P258-; ORF8: D119-, F120-; S: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V","spike_mutations":"L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V"}}}]}]},{"name":"NODE_0000441","node_attrs":{"div":7,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G11230T","G28167A"],"ORF1a":["M3655I"],"ORF8":["E92K"]},"labels":{"aa":"ORF1a: M3655I; ORF8: E92K"}},"children":[{"name":"A.25","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.25"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.25"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5544T"],"ORF1a":["T1760I"]},"labels":{"aa":"ORF1a: T1760I"}}},{"name":"A.29","node_attrs":{"div":24,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"S:142-143"},"partiallyAliased":{"value":"A.29"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-21"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G521T","C2110T","C8605T","C9891T","C12970T","G17964T","A19426G","A21069G","G21255T","T21982-","T21983-","T21984-","G21985-","T21992-","A21993-","A22194-","T22195-","T22196-","T22907C","A23063T","T23255C","C23525T","T26767G","G27604T","A28271-","G28337T","C29739T"],"M":["I82S"],"N":["D22Y"],"ORF1a":["V86F","A3209V"],"ORF1b":["M1499I","I1987V"],"ORF7a":["V71L"],"ORF9b":["Q18H"],"S":["F140-","L141-","Y144-","N211-","L212I","Y449H","N501Y","F565L","H655Y"]},"labels":{"aa":"M: I82S; N: D22Y; ORF1a: V86F, A3209V; ORF1b: M1499I, I1987V; ORF7a: V71L; ORF9b: Q18H; S: F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y","spike_mutations":"F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y"}}},{"name":"NODE_0000442","node_attrs":{"div":18,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C4573T","C10747T","G11266T","C16575T","C17745T","C22000T","C22033A","G22661T","G23401T","T24097C","G28378C"],"ORF1a":["L3667F"],"ORF9b":["R32P"],"S":["F157L","V367F","Q613H"]},"labels":{"aa":"ORF1a: L3667F; ORF9b: R32P; S: F157L, V367F, Q613H","spike_mutations":"F157L, V367F, Q613H"}},"children":[{"name":"A.23","node_attrs":{"div":18,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.23"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"A.23.1","node_attrs":{"div":20,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.23.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["G11521T","C23604G"],"ORF1a":["M3752I"],"S":["P681R"]},"labels":{"aa":"ORF1a: M3752I; S: P681R","spike_mutations":"P681R"}}}]}]}]}]},{"name":"NODE_0000443","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C14408T","A23403G"],"ORF1b":["P314L"],"S":["D614G"]},"labels":{"aa":"ORF1b: P314L; S: D614G","clade":"20A","spike_mutations":"D614G"}},"children":[{"name":"B.1","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{}}},{"name":"B.1.126","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.126"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.126"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1042866706848145}},"branch_attrs":{"mutations":{"nuc":["T3011C","G22205T","T27869C","T28853G"],"N":["S194A"],"S":["D215Y"]},"labels":{"aa":"N: S194A; S: D215Y","spike_mutations":"D215Y"}}},{"name":"B.1.143","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.143"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.143"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.873954772949219}},"branch_attrs":{"mutations":{"nuc":["C4084T"]}}},{"name":"B.1.128","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.128"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.128"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9753756523132324}},"branch_attrs":{"mutations":{"nuc":["C8293T","T18488C","T24739C","A26530G"],"M":["D3G"],"ORF1b":["I1674T"]},"labels":{"aa":"M: D3G; ORF1b: I1674T"}}},{"name":"B.1.179","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.179"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.179"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.5756611824035645}},"branch_attrs":{"mutations":{"nuc":["C7834T"]}}},{"name":"B.1.195","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.195"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.195"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.644052028656006}},"branch_attrs":{"mutations":{"nuc":["A1T","A6466G"]}}},{"name":"B.1.206","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.206"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.206"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.032867431640625}},"branch_attrs":{"mutations":{"nuc":["G2282A","T9742C","C17639T"],"ORF1a":["E673K"],"ORF1b":["S1391L"]},"labels":{"aa":"ORF1a: E673K; ORF1b: S1391L"}}},{"name":"B.1.22","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.22"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.22"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.218015670776367}},"branch_attrs":{"mutations":{"nuc":["C1594T","C11109T","G25563T"],"ORF1a":["A3615V"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: A3615V; ORF3a: Q57H"}}},{"name":"B.1.222","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.222"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.222"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.234422206878662}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.247","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.247"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.247"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{}}},{"name":"B.1.260","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.260"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.260"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.373773574829102}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}}},{"name":"B.1.298","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.298"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.298"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.417770862579346}},"branch_attrs":{"mutations":{"nuc":["C1059T","G5012T","C19488T","G25563T","T28843G"],"N":["S190R"],"ORF1a":["T265I","V1583F"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S190R; ORF1a: T265I, V1583F; ORF3a: Q57H"}}},{"name":"B.1.311","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.311"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.311"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6185555458068848}},"branch_attrs":{"mutations":{"nuc":["C1059T","A5011C","C12525T","G25563T","C27920T","C28893T"],"N":["P207L"],"ORF1a":["T265I","Q1582H","T4087I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: P207L; ORF1a: T265I, Q1582H, T4087I; ORF3a: Q57H"}}},{"name":"B.1.319","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.319"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.319"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.19646692276001}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10851T","G25563T"],"ORF1a":["T265I","A3529V"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, A3529V; ORF3a: Q57H"}}},{"name":"B.1.324","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.324"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.324"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.300193786621094}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7528T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.320","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.320"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.320"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.052657604217529}},"branch_attrs":{"mutations":{"nuc":["A1G","C379A","C1059T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.349","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.349"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.349"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.087948799133301}},"branch_attrs":{"mutations":{"nuc":["C1059T","C18555T","G25563T","C28892T"],"N":["P207S"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: P207S; ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.340","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.340"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.340"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.638462543487549}},"branch_attrs":{"mutations":{"nuc":["C1059T","A4197G","G25563T","A28715T"],"N":["T148S"],"ORF1a":["T265I","E1311G"],"ORF3a":["Q57H"]},"labels":{"aa":"N: T148S; ORF1a: T265I, E1311G; ORF3a: Q57H"}}},{"name":"B.1.350","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.350"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.350"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515401363372803}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25217T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"S":["G1219C"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; S: G1219C","spike_mutations":"G1219C"}}},{"name":"B.1.356","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.356"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.356"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.372903347015381}},"branch_attrs":{"mutations":{"nuc":["C1059T","T13006C","G25563T","C25688T"],"ORF1a":["T265I"],"ORF3a":["Q57H","A99V"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H, A99V"}}},{"name":"B.1.371","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.371"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.371"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0627546310424805}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","G29553A"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.377","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.377"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.377"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.690332889556885}},"branch_attrs":{"mutations":{"nuc":["G28300T","G28883A","A28998G"],"N":["Q9H","G204R","Q242R"],"ORF9b":["S6I"]},"labels":{"aa":"N: Q9H, G204R, Q242R; ORF9b: S6I"}}},{"name":"B.1.379","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.379"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.379"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.871178150177002}},"branch_attrs":{"mutations":{"nuc":["A11782G"]}}},{"name":"B.1.380","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.380"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.380"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0439043045043945}},"branch_attrs":{"mutations":{"nuc":["C7420T","C12439T","T26017G"],"ORF3a":["S209A"]},"labels":{"aa":"ORF3a: S209A"}}},{"name":"B.1.391","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.391"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.391"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.035602569580078}},"branch_attrs":{"mutations":{"nuc":["C16289T","G25429T"],"ORF1b":["A941V"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1b: A941V; ORF3a: V13L"}}},{"name":"B.1.393","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.393"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.393"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.20594596862793}},"branch_attrs":{"mutations":{"nuc":["A5040G","G29477T","C29774T"],"N":["D402Y"],"ORF1a":["Q1592R"]},"labels":{"aa":"N: D402Y; ORF1a: Q1592R"}}},{"name":"B.1.395","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.395"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.395"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.245898246765137}},"branch_attrs":{"mutations":{"nuc":["C6990T"],"ORF1a":["S2242F"]},"labels":{"aa":"ORF1a: S2242F"}}},{"name":"B.1.411","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.411"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.411"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.553281307220459}},"branch_attrs":{"mutations":{"nuc":["C1519T","A14774G","G15438T","T16062C","G17334T","C25037T","C27945T"],"ORF1b":["D436G","M657I"],"ORF8":["Q18*"],"S":["H1159Y"]},"labels":{"aa":"ORF1b: D436G, M657I; ORF8: Q18*; S: H1159Y","spike_mutations":"H1159Y"}}},{"name":"B.1.428","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.428"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.428"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.162219524383545}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1302T","G25563T"],"ORF1a":["T265I","T346I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, T346I; ORF3a: Q57H"}}},{"name":"B.1.453","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.453"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.453"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.023926258087158}},"branch_attrs":{"mutations":{"nuc":["C1059T","C2668T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.517","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.517"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.517"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8103365898132324}},"branch_attrs":{"mutations":{"nuc":["C1059T","G3231T","A12850G","C21364T","A23064C","G25563T","C28890T"],"N":["S206F"],"ORF1a":["T265I","G989V"],"ORF1b":["P2633S"],"ORF3a":["Q57H"],"S":["N501T"]},"labels":{"aa":"N: S206F; ORF1a: T265I, G989V; ORF1b: P2633S; ORF3a: Q57H; S: N501T","spike_mutations":"N501T"}}},{"name":"B.1.527","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.527"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.527"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.679739952087402}},"branch_attrs":{"mutations":{"nuc":["A1G","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}}},{"name":"B.1.537","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.537"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.537"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.6834211349487305}},"branch_attrs":{"mutations":{"nuc":["G4354A","C6573T","C25528T"],"ORF1a":["S2103F"],"ORF3a":["L46F"]},"labels":{"aa":"ORF1a: S2103F; ORF3a: L46F"}}},{"name":"B.1.538","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.538"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.538"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.957637310028076}},"branch_attrs":{"mutations":{"nuc":["C313T","C5700A","C29870A"],"ORF1a":["A1812D"]},"labels":{"aa":"ORF1a: A1812D"}}},{"name":"B.1.540","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.540"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.540"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.101133823394775}},"branch_attrs":{"mutations":{"nuc":["G28221T"],"ORF8":["E110*"]},"labels":{"aa":"ORF8: E110*"}}},{"name":"B.1.544","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.544"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.544"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.623403549194336}},"branch_attrs":{"mutations":{"nuc":["G13348T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"B.1.549","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.549"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.549"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.000475883483887}},"branch_attrs":{"mutations":{"nuc":["C1514T","G5542T","C10029T","A11451G","G17122T","G17320T","C18463T","G23611A"],"ORF1a":["H417Y","Q1759H","T3255I","Q3729R"],"ORF1b":["A1219S","A1285S","P1666S"]},"labels":{"aa":"ORF1a: H417Y, Q1759H, T3255I, Q3729R; ORF1b: A1219S, A1285S, P1666S"}}},{"name":"B.1.560","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.560"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.560"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.553897380828857}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}}},{"name":"B.1.566","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.566"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.566"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.201295375823975}},"branch_attrs":{"mutations":{"nuc":["C1059T","C13860T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.570","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.570"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.570"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.377383232116699}},"branch_attrs":{"mutations":{"nuc":["C1059T","T7767C","G11087A","C13452T","C21161T","C23604T","G25455T","G25563T","T29867A","G29868A","C29870A"],"ORF1a":["T265I","I2501T","E3608K","A4396V"],"ORF1b":["A2565V"],"ORF3a":["K21N","Q57H"],"S":["P681L"]},"labels":{"aa":"ORF1a: T265I, I2501T, E3608K, A4396V; ORF1b: A2565V; ORF3a: K21N, Q57H; S: P681L","spike_mutations":"P681L"}}},{"name":"B.1.576","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.576"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.576"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.5748648643493652}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.606","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.606"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.606"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.854406833648682}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10015T","G14829T","C23191T","G25563T","G26769T"],"M":["A83S"],"ORF1a":["T265I"],"ORF1b":["M454I"],"ORF3a":["Q57H"]},"labels":{"aa":"M: A83S; ORF1a: T265I; ORF1b: M454I; ORF3a: Q57H"}}},{"name":"B.1.605","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.605"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.605"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.770111560821533}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10747T","C13694T","T14103C","C24909A","G25563T"],"ORF1a":["T265I"],"ORF1b":["T76I"],"ORF3a":["Q57H"],"S":["T1116N"]},"labels":{"aa":"ORF1a: T265I; ORF1b: T76I; ORF3a: Q57H; S: T1116N","spike_mutations":"T1116N"}}},{"name":"B.1.618","node_attrs":{"div":25,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.618"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.618"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-13"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G105T","C853T","C1684T","A3830G","C4809T","T5263C","G14245A","A17066G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","G23012A","T25084C","C25844T","C26885T","G26909T","C27493T","G27852T","A27979T","G28325A","G28628T","G28922T","G28975T","G29372C"],"N":["G18S","A119S","A217S","M234I","E367Q"],"ORF1a":["S1189G","S1515F"],"ORF1b":["D260N","Y1200C"],"ORF3a":["T151I"],"ORF7a":["P34S"],"ORF7b":["E33*"],"ORF8":["Q29L"],"S":["Y145-","H146-","E484K"]},"labels":{"aa":"N: G18S, A119S, A217S, M234I, E367Q; ORF1a: S1189G, S1515F; ORF1b: D260N, Y1200C; ORF3a: T151I; ORF7a: P34S; ORF7b: E33*; ORF8: Q29L; S: Y145-, H146-, E484K","spike_mutations":"Y145-, H146-, E484K"}}},{"name":"B.1.639","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.639"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.639"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.9996724128723145}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22020C","C22995A","G23012A","C24138A","G24368T","A26161-","T27919C","A28271G","A28742G"],"N":["I157V"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF3a":["N257-"],"ORF8":["I9T"],"S":["H69-","V70-","M153T","T478K","E484K","T859N","D936Y"]},"labels":{"aa":"N: I157V; ORF1a: S3675-, G3676-, F3677-; ORF3a: N257-; ORF8: I9T; S: H69-, V70-, M153T, T478K, E484K, T859N, D936Y","spike_mutations":"H69-, V70-, M153T, T478K, E484K, T859N, D936Y"}}},{"name":"B.1.78","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.78"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.78"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.457021713256836}},"branch_attrs":{"mutations":{"nuc":["G29422T"]}}},{"name":"B.1.8","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.388116359710693}},"branch_attrs":{"mutations":{"nuc":["A24862G"]}}},{"name":"B.1.91","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.91"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.91"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.194854259490967}},"branch_attrs":{"mutations":{"nuc":["G24077T"],"S":["D839Y"]},"labels":{"aa":"S: D839Y","spike_mutations":"D839Y"}}},{"name":"NODE_0000444","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515961647033691}},"branch_attrs":{"mutations":{"nuc":["C8389T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.110","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.110"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515961647033691}},"branch_attrs":{"mutations":{}}},{"name":"B.1.110.3","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.110.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.013051509857178}},"branch_attrs":{"mutations":{"nuc":["C601T","G27915A"],"ORF8":["G8R"]},"labels":{"aa":"ORF8: G8R"}}}]},{"name":"NODE_0000445","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.175020217895508}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10582T","G25563T","C27804T","C28830A"],"N":["S186Y"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S186Y; ORF1a: T265I; ORF3a: Q57H"}},"children":[{"name":"B.1.367","node_attrs":{"div":27,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.367"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.367"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C3099T","G4960T","C4965T","C6070T","C7303T","C7564T","C9246T","C10279T","C10301A","C10525T","G10688T","G11851T","C14230A","G21800T","G27632T","G29402T","G29779T"],"N":["D377Y"],"ORF1a":["T945I","T1567I","A2994V","Q3346K","V3475F","M3862I"],"ORF1b":["P255T"],"ORF7a":["R80I"],"S":["D80Y"]},"labels":{"aa":"N: D377Y; ORF1a: T945I, T1567I, A2994V, Q3346K, V3475F, M3862I; ORF1b: P255T; ORF7a: R80I; S: D80Y","spike_mutations":"D80Y"}}},{"name":"B.1.597","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.597"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.597"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.175020217895508}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000446","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{"nuc":["C1059T","C16260T","G25563T","C28821A"],"N":["S183Y"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S183Y; ORF1a: T265I; ORF3a: Q57H"}},"children":[{"name":"B.1.369","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.369"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.369"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{"nuc":["A1C"]}}},{"name":"B.1.564","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.564"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.564"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000447","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.648159980773926}},"branch_attrs":{"mutations":{"nuc":["C2416T","C14322T","C23604A","G23948T","G25563T","T26038C"],"ORF3a":["Q57H","S216P"],"S":["P681H","D796Y"]},"labels":{"aa":"ORF3a: Q57H, S216P; S: P681H, D796Y","spike_mutations":"P681H, D796Y"}},"children":[{"name":"B.1.474","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.474"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.474"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.585629463195801}},"branch_attrs":{"mutations":{"nuc":["C539T","C5884T","C7834T","G8618A","C15579T","G16912T","C25207T","C26600T","C27970A","C28887T"],"N":["T205I"],"ORF1a":["L92F","A2785T"],"ORF1b":["V1149L"],"ORF8":["T26N"]},"labels":{"aa":"N: T205I; ORF1a: L92F, A2785T; ORF1b: V1149L; ORF8: T26N"}}},{"name":"B.1.629","node_attrs":{"div":29,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.629"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.629"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-01"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C815T","C1191T","C3040T","A4229C","T5095C","C5178T","G11128A","C12459T","G21987A","A22107G","T22917G","C22995A","G25266T","C25433T","T26498C","T26767G","A28482G","C28833T","C28926T"],"M":["I82S"],"N":["Q70R","S187L","A218V"],"ORF1a":["R184C","P309L","T1322P","T1638I","M3621I","T4065I"],"ORF3a":["T14I"],"ORF9b":["K67E"],"S":["G142D","K182R","L452R","T478K","C1235F"]},"labels":{"aa":"M: I82S; N: Q70R, S187L, A218V; ORF1a: R184C, P309L, T1322P, T1638I, M3621I, T4065I; ORF3a: T14I; ORF9b: K67E; S: G142D, K182R, L452R, T478K, C1235F","spike_mutations":"G142D, K182R, L452R, T478K, C1235F"}}}]},{"name":"NODE_0000448","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.43609094619751}},"branch_attrs":{"mutations":{"nuc":["C1059T","T9867C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C25517T","G25563T","C27925T","A28271-"],"ORF1a":["T265I","L3201P","S3675-","G3676-","F3677-"],"ORF3a":["P42L","Q57H"],"ORF8":["T11I"]},"labels":{"aa":"ORF1a: T265I, L3201P, S3675-, G3676-, F3677-; ORF3a: P42L, Q57H; ORF8: T11I"}},"children":[{"name":"B.1.526","node_attrs":{"div":14,"clade_display":{"value":"21F (Iota)"},"Nextclade_pango":{"value":"B.1.526"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21F"},"clade_who":{"value":"Iota"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.526"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"21F"},"placement_prior":{"value":-2.5307040214538574}},"branch_attrs":{"mutations":{"nuc":["A16500C","A20262G","C21575T","C21846T","A22320G"],"ORF1b":["Q1011H"],"S":["L5F","T95I","D253G"]},"labels":{"aa":"ORF1b: Q1011H; S: L5F, T95I, D253G","clade":"Iota","spike_mutations":"L5F, T95I, D253G"}}},{"name":"B.1.637","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.637"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.637"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0134620666503906}},"branch_attrs":{"mutations":{"nuc":["A9749G","C9891T","G11804A","A21801G","T21992-","A21993-","T21994-","T22032C","T22917G","C24138A","G24410C","G28044T","C28887T","G28975A"],"N":["T205I","M234I"],"ORF1a":["K3162E","A3209V","V3847I"],"ORF8":["A51S"],"S":["D80G","Y144-","F157S","L452R","T859N","D950H"]},"labels":{"aa":"N: T205I, M234I; ORF1a: K3162E, A3209V, V3847I; ORF8: A51S; S: D80G, Y144-, F157S, L452R, T859N, D950H","spike_mutations":"D80G, Y144-, F157S, L452R, T859N, D950H"}}}]},{"name":"NODE_0000449","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.79054069519043}},"branch_attrs":{"mutations":{"nuc":["G3871T"],"ORF1a":["K1202N"]},"labels":{"aa":"ORF1a: K1202N"}},"children":[{"name":"B.1.378","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.378"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.378"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.79054069519043}},"branch_attrs":{"mutations":{"nuc":["A6-","G7-","G8-","T9-","T13-","A14-","C15-","C16-","T17-","T18-","C19-","C20-","C21-","A22-","G23-","G24-"]}}},{"name":"NODE_0000450","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.390692710876465}},"branch_attrs":{"mutations":{"nuc":["A696C","T3931C","C28977T"],"N":["S235F"],"ORF1a":["D144A"]},"labels":{"aa":"N: S235F; ORF1a: D144A"}},"children":[{"name":"B.1.139","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.139"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.139"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.390692710876465}},"branch_attrs":{"mutations":{}}},{"name":"B.1.565","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.565"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.565"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.867055892944336}},"branch_attrs":{"mutations":{"nuc":["C6285T","C19524T","C20429T"],"ORF1a":["T2007I"],"ORF1b":["P2321L"]},"labels":{"aa":"ORF1a: T2007I; ORF1b: P2321L"}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.336426258087158}},"branch_attrs":{"mutations":{"nuc":["C1059T","C6730T","T23042C","C23604A","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"S":["S494P","P681H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; S: S494P, P681H","spike_mutations":"S494P, P681H"}},"children":[{"name":"B.1.623","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.623"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.623"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-13"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["T8704C","C9120T","C9870T","C11005A","C12854T","C13458T","G14559A","A23063T","G24893A","A27926-","A27927-","C27928-","T27929-","G27930-","T27931-","A27932-","G27933-","C27934-","T27935-","G27936-","C27937-","A27938-","T27939-","T27940-","T27941-","C27942-","A27943-","C27944-","C27945-","A27946-","A27947-","G27948-","A27949-","A27950-","T27951-","G27952-","T27953-","A27954-","G27955-","A28272T","G28975A"],"N":["M234I"],"ORF1a":["T2952I","T3202M","H3580Q","P4197S","S4398L"],"ORF8":["T12-","V13-","A14-","A15-","F16-","H17-","Q18-","E19-","C20-","S21-"],"S":["N501Y","E1111K"]},"labels":{"aa":"N: M234I; ORF1a: T2952I, T3202M, H3580Q, P4197S, S4398L; ORF8: T12-, V13-, A14-, A15-, F16-, H17-, Q18-, E19-, C20-, S21-; S: N501Y, E1111K","spike_mutations":"N501Y, E1111K"}}},{"name":"NODE_0000452","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8313348293304443}},"branch_attrs":{"mutations":{"nuc":["A1C","A1180G","C6936T","C10029T","C11514T","C16375T","T20748C","C23709T","T26767C","A28271-","C28887T","G29711-","C29719T"],"M":["I82T"],"N":["T205I"],"ORF1a":["S2224F","T3255I","T3750I"],"ORF1b":["P970S"],"S":["T716I"]},"labels":{"aa":"M: I82T; N: T205I; ORF1a: S2224F, T3255I, T3750I; ORF1b: P970S; S: T716I","spike_mutations":"T716I"}},"children":[{"name":"B.1.575","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.575"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8313348293304443}},"branch_attrs":{"mutations":{}}},{"name":"B.1.575.1","node_attrs":{"div":22,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.575.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.644876003265381}},"branch_attrs":{"mutations":{"nuc":["G29513T","C29614T"],"N":["A414S"]},"labels":{"aa":"N: A414S"}}}]}]},{"name":"NODE_0000453","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.800264835357666}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","C23625T","A26161-"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"B.1.634","node_attrs":{"div":27,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.634"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.634"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G613A","C841T","A7142G","T8634C","A9614G","C9693T","A9754C","C11289-","G11291-","G11292-","G15451A","C16466T","C20823T","T21615G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A22036C","G23012A","C23854A","C26681T","T27645C","C27735T","A28271T","C28531T","C28606T","A28910T"],"N":["N213Y"],"ORF1a":["S2293G","I2790T","T3117A","A3143V","R3163S","S3675-","G3676-","F3677-"],"ORF1b":["G662S","P1000L"],"ORF3a":["N257-"],"ORF9b":["T83I"],"S":["L18R","H69-","V70-","T95I","R158S","E484K","N764K"]},"labels":{"aa":"N: N213Y; ORF1a: S2293G, I2790T, T3117A, A3143V, R3163S, S3675-, G3676-, F3677-; ORF1b: G662S, P1000L; ORF3a: N257-; ORF9b: T83I; S: L18R, H69-, V70-, T95I, R158S, E484K, N764K","spike_mutations":"L18R, H69-, V70-, T95I, R158S, E484K, N764K"}}},{"name":"NODE_0000454","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.438127517700195}},"branch_attrs":{"mutations":{"nuc":["C24642T"],"S":["T1027I"]},"labels":{"aa":"S: T1027I","spike_mutations":"T1027I"}},"children":[{"name":"B.1.636","node_attrs":{"div":18,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.636"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.636"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","C5907T","C5986T","A9085G","C11289-","G11291-","G11292-","C21614T","A22005C","G23867A","C25931T","-26161A","C27925T","A28295T","A28742G","G29734C"],"N":["N8Y","I157V"],"ORF1a":["T1881I","S3675-","G3676-","F3677-"],"ORF3a":["S180F"],"ORF8":["T11I"],"ORF9b":["K4N"],"S":["L18F","N148T","G769R"]},"labels":{"aa":"N: N8Y, I157V; ORF1a: T1881I, S3675-, G3676-, F3677-; ORF3a: S180F; ORF8: T11I; ORF9b: K4N; S: L18F, N148T, G769R","spike_mutations":"L18F, N148T, G769R"}}},{"name":"NODE_0000455","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A994G","G9756A","C9924T","A10982G","G11283-","T11284-","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C23604A","T23765G","C24442T","G26158-","T26159-","T26160-","C26222T"],"ORF1a":["R3164H","A3220V","K3573E","S3673-"],"ORF3a":["V256-","N257-"],"S":["P681H","S735A"]},"labels":{"aa":"ORF1a: R3164H, A3220V, K3573E, S3673-; ORF3a: V256-, N257-; S: P681H, S735A","spike_mutations":"P681H, S735A"}},"children":[{"name":"B.1.627","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.627"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.627"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-01"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C1912T","C7869T","C9611T","T11285-","T20124A","T21752A","T22020C","C28923T","T29574-","T29575-","T29576-","T29577-","C29578-","G29579-","C29580-"],"N":["A217V"],"ORF1a":["S2535L","L3116F","L3674M"],"S":["W64R","M153T"]},"labels":{"aa":"N: A217V; ORF1a: S2535L, L3116F, L3674M; S: W64R, M153T","spike_mutations":"W64R, M153T"}}},{"name":"B.1.631","node_attrs":{"div":28,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.631"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.631"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-26"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C829T","C4534T","C6120T","G7787A","A11282-","T21615G","C21846T","A22036C","C22916A","C25465T","C27769T","A28271-","A28330G","C28830T","G28907T","C28957T"],"N":["S186F","G212C"],"ORF1a":["S1952L","A2508T"],"ORF3a":["P25S"],"ORF7b":["S5L"],"ORF9b":["D16G"],"S":["L18R","T95I","R158S","L452M"]},"labels":{"aa":"N: S186F, G212C; ORF1a: S1952L, A2508T; ORF3a: P25S; ORF7b: S5L; ORF9b: D16G; S: L18R, T95I, R158S, L452M","spike_mutations":"L18R, T95I, R158S, L452M"}}}]}]}]},{"name":"NODE_0000456","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8648552894592285}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.524","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.524"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.524"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.313449859619141}},"branch_attrs":{"mutations":{"nuc":["C6312T","C8637T","A10124G","C17518T","C21516T","C21622A","C23664T","A28133T"],"ORF1a":["T2016I","T2791I","T3287A"],"ORF1b":["L1351F"],"S":["A701V"]},"labels":{"aa":"ORF1a: T2016I, T2791I, T3287A; ORF1b: L1351F; S: A701V","spike_mutations":"A701V"}}},{"name":"NODE_0000457","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.2996320724487305}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.362","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.362"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.362"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.244770526885986}},"branch_attrs":{"mutations":{"nuc":["C683T","C1059T","C6402T","T10249C","G11083T","G17427T"],"ORF1a":["T265I","P2046L","L3606F"]},"labels":{"aa":"ORF1a: T265I, P2046L, L3606F"}}},{"name":"NODE_0000458","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.4366543292999268}},"branch_attrs":{"mutations":{"nuc":["C2416T"]}},"children":[{"name":"B.1.279","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.279"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.279"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.854538679122925}},"branch_attrs":{"mutations":{"nuc":["C1913T","G2528A","C12525T","C16806T","G20014T","A25718G","T28854C"],"N":["L194S"],"ORF1a":["R550C","E755K","T4087I"],"ORF1b":["D2183Y"],"ORF3a":["Y109C"]},"labels":{"aa":"N: L194S; ORF1a: R550C, E755K, T4087I; ORF1b: D2183Y; ORF3a: Y109C"}}},{"name":"B.1.389","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.389"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.389"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G8371T","C9430T","A15477T","C18395T","A20622T","G20623T","A20624T","C23730T","A26319G","G29044A"],"ORF1a":["Q2702H"],"ORF1b":["A1643V","K2385N","D2386F"],"S":["T723I"]},"labels":{"aa":"ORF1a: Q2702H; ORF1b: A1643V, K2385N, D2386F; S: T723I","spike_mutations":"T723I"}}},{"name":"B.1.480","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.480"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.480"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.699548721313477}},"branch_attrs":{"mutations":{"nuc":["C875T","A10904G","G25249T"],"ORF1a":["L204F","S3547G"],"S":["M1229I"]},"labels":{"aa":"ORF1a: L204F, S3547G; S: M1229I","spike_mutations":"M1229I"}}}]}]}]},{"name":"NODE_0000459","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.48314905166626}},"branch_attrs":{"mutations":{"nuc":["C1059T","A10323G","G25563T","G28842T"],"N":["S190I"],"ORF1a":["T265I","K3353R"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S190I; ORF1a: T265I, K3353R; ORF3a: Q57H"}},"children":[{"name":"B.1.361","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.361"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.361"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0868425369262695}},"branch_attrs":{"mutations":{"nuc":["A705G","G1463A","G11417T","C18167T","A21080G","G29779T"],"ORF1a":["D147G","G400S","V3718F"],"ORF1b":["P1567L","K2538R"]},"labels":{"aa":"ORF1a: D147G, G400S, V3718F; ORF1b: P1567L, K2538R"}}},{"name":"B.1.580","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.580"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.580"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.48314905166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000460","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{"nuc":["T15276A"]}},"children":[{"name":"B.1.568","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.568"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.568"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097565650939941}},"branch_attrs":{"mutations":{"nuc":["C5654T","C10450T","C12049T","C12455A","C16428T","C17483T","G25913A","G27916T"],"ORF1a":["L4064I"],"ORF1b":["T1339I"],"ORF3a":["G174D"],"ORF8":["G8V"]},"labels":{"aa":"ORF1a: L4064I; ORF1b: T1339I; ORF3a: G174D; ORF8: G8V"}}},{"name":"B.1.582","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.582"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.582"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{}}},{"name":"B.1.612","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.612"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.612"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000461","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.893455743789673}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.530","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.530"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.530"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G61T","A3291G","C11050T","G16935T","A19339G","C23604A","C26549T","T29471C"],"ORF1a":["Q1009R"],"ORF1b":["M1156I","S1958G"],"S":["P681H"]},"labels":{"aa":"ORF1a: Q1009R; ORF1b: M1156I, S1958G; S: P681H","spike_mutations":"P681H"}}},{"name":"NODE_0000462","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.436675548553467}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","A21768-","T21769-","G21770-","G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.415.1","node_attrs":{"div":29,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.415.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.415.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1150T","T7185C","C8251T","A11023T","A11217G","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C13458T","G15732T","T16348C","A16619G","A18410G","T19143C","A20268G","C21767-","C22286-","T22287-","T22288-","G22299C","G22599A","A23064C","C23604A","C24138A","C24507T","G26840T","G28178A","A28271-","G28302A","C28932T"],"N":["R10Q","A220V"],"ORF1a":["I2307T","N3651S","S4398L"],"ORF1b":["S961P","E1051G","Y1648C"],"ORF9b":["E7K"],"S":["H69-","V70-","L241-","R246T","R346K","N501T","P681H","T859N","S982L"]},"labels":{"aa":"N: R10Q, A220V; ORF1a: I2307T, N3651S, S4398L; ORF1b: S961P, E1051G, Y1648C; ORF9b: E7K; S: H69-, V70-, L241-, R246T, R346K, N501T, P681H, T859N, S982L","spike_mutations":"H69-, V70-, L241-, R246T, R346K, N501T, P681H, T859N, S982L"}}},{"name":"B.1.525","node_attrs":{"div":24,"clade_display":{"value":"21D (Eta)"},"Nextclade_pango":{"value":"B.1.525"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21D"},"clade_who":{"value":"Eta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.525"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"21D"},"placement_prior":{"value":-3.212512969970703}},"branch_attrs":{"mutations":{"nuc":["C1498T","A1807G","G2659A","C6285T","T8593C","C9565T","C11289-","G11291-","G11292-","C14407T","C18171T","A20724G","A21717G","C21762T","C21767-","T21992-","A21993-","T21994-","G23593C","T24224C","C24748T","T27205-","T27206-","T27207-","C28278-","T28279-","G28280-","C28308G","A28699G","G29543T"],"N":["S2-","D3Y","A12G"],"ORF1a":["T2007I","S3675-","G3676-","F3677-"],"ORF1b":["L314F"],"ORF6":["F2-"],"ORF9b":["H9D"],"S":["Q52R","A67V","H69-","V70-","Y144-","Q677H","F888L"]},"labels":{"aa":"N: S2-, D3Y, A12G; ORF1a: T2007I, S3675-, G3676-, F3677-; ORF1b: L314F; ORF6: F2-; ORF9b: H9D; S: Q52R, A67V, H69-, V70-, Y144-, Q677H, F888L","clade":"Eta","spike_mutations":"Q52R, A67V, H69-, V70-, Y144-, Q677H, F888L"}}},{"name":"NODE_0000463","node_attrs":{"div":30,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2407A","G5008T","C6633T","G8084A","C8311T","C9319T","C11289-","G11291-","G11292-","G11521T","C12473T","C14403T","C15324T","G19962A","C21637T","-21765T","-21766A","-21768A","-21769T","-21770G","T22191C","T22882G","T24194C","G24368A","C24378T","C24642T","G26211T","C26606T","G27459T","C28311T","G28875T"],"N":["P13L","S201I"],"ORF1a":["A2123V","E2607K","S3675-","G3676-","F3677-","M3752I"],"ORF7a":["E22D"],"ORF9b":["P10S"],"S":["I210T","N440K","D936N","S939F","T1027I"]},"labels":{"aa":"N: P13L, S201I; ORF1a: A2123V, E2607K, S3675-, G3676-, F3677-, M3752I; ORF7a: E22D; ORF9b: P10S; S: I210T, N440K, D936N, S939F, T1027I","spike_mutations":"I210T, N440K, D936N, S939F, T1027I"}},"children":[{"name":"B.1.619.1","node_attrs":{"div":38,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.619.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-27"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C19T","T5701C","A12051G","A21213G","T22738C","A28271-","C28441T","T28600C","C28957T"],"ORF1a":["K3929R"],"ORF9b":["S53L"]},"labels":{"aa":"ORF1a: K3929R; ORF9b: S53L"}}},{"name":"B.1.619","node_attrs":{"div":30,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.619"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-20"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000464","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.037975788116455}},"branch_attrs":{"mutations":{"nuc":["C1059T","C11916T","G25563T"],"ORF1a":["T265I","S3884L"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, S3884L; ORF3a: Q57H"}},"children":[{"name":"B.1.3","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C715T","A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"B.1.497","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.497"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.497"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A1G","C16650T","A20675T","G29179T"],"ORF1b":["Q2403L"]},"labels":{"aa":"ORF1b: Q2403L"}}},{"name":"B.1.509","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.509"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.509"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097174167633057}},"branch_attrs":{"mutations":{"nuc":["C1385T","G1738T","G3242A","C28087T"],"ORF1a":["H374Y","G993S"],"ORF8":["A65V"]},"labels":{"aa":"ORF1a: H374Y, G993S; ORF8: A65V"}}},{"name":"NODE_0000465","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8570423126220703}},"branch_attrs":{"mutations":{"nuc":["C18998T","G29540A"],"ORF1b":["A1844V"]},"labels":{"aa":"ORF1b: A1844V"}},"children":[{"name":"B.1.503","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.503"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.503"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25947C"],"ORF3a":["Q185H"]},"labels":{"aa":"ORF3a: Q185H"}}},{"name":"B.1.499","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.499"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.499"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["C28863T"],"N":["S197L"]},"labels":{"aa":"N: S197L"}}},{"name":"B.1.505","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.505"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.505"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C66A","C7768T","A8773G","C17304T","T24805C"]}}}]}]},{"name":"NODE_0000466","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.3400766849517822}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","C27964T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"ORF8":["S24L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; ORF8: S24L"}},"children":[{"name":"B.1.265","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.265"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.265"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.216925144195557}},"branch_attrs":{"mutations":{"nuc":["C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}}},{"name":"B.1.336","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.336"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.336"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.552525043487549}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}}},{"name":"B.1.426","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.426"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.426"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8291878700256348}},"branch_attrs":{"mutations":{"nuc":["T833C","A22320G"],"ORF1a":["F190L"],"S":["D253G"]},"labels":{"aa":"ORF1a: F190L; S: D253G","spike_mutations":"D253G"}}},{"name":"NODE_0000467","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.473392963409424}},"branch_attrs":{"mutations":{"nuc":["A18424G","G25907T"],"ORF1b":["N1653D"],"ORF3a":["G172V"]},"labels":{"aa":"ORF1b: N1653D; ORF3a: G172V"}},"children":[{"name":"B.1.2","node_attrs":{"div":13,"clade_display":{"value":"20G"},"Nextclade_pango":{"value":"B.1.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20G"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20G"},"placement_prior":{"value":-2.0290510654449463}},"branch_attrs":{"mutations":{"nuc":["C10319T","C21304T","C28472T","C28869T"],"N":["P67S","P199L"],"ORF1a":["L3352F"],"ORF1b":["R2613C"]},"labels":{"aa":"N: P67S, P199L; ORF1a: L3352F; ORF1b: R2613C","clade":"20G"}}},{"name":"B.1.596","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.596"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.596"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.473392963409424}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000468","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7301440238952637}},"branch_attrs":{"mutations":{"nuc":["C10319T"],"ORF1a":["L3352F"]},"labels":{"aa":"ORF1a: L3352F"}},"children":[{"name":"B.1.567","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.567"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.567"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.657745838165283}},"branch_attrs":{"mutations":{"nuc":["C11575T","A20262G","G21305A","C28868T"],"N":["P199S"],"ORF1b":["R2613H"]},"labels":{"aa":"N: P199S; ORF1b: R2613H"}}},{"name":"B.1.577","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.577"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.577"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8689005374908447}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"B.1.595","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.595"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.595"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7301440238952637}},"branch_attrs":{"mutations":{"nuc":["A1G"]}}},{"name":"NODE_0000469","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.712774276733398}},"branch_attrs":{"mutations":{"nuc":["G6052A","G19872T","G25855T","G29254T","G29474T"],"N":["D401Y"],"ORF3a":["D155Y"]},"labels":{"aa":"N: D401Y; ORF3a: D155Y"}},"children":[{"name":"B.1.588","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.588"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.588"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{"nuc":["C7600T","G7675C","C21621T","G22201T","G28975T","G29764T"],"N":["M234I"],"S":["T20I"]},"labels":{"aa":"N: M234I; S: T20I","spike_mutations":"T20I"}}},{"name":"B.1.587","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.587"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.587"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.289678573608398}},"branch_attrs":{"mutations":{"nuc":["T5122C","G20102T","C20117T","A22095G"],"ORF1b":["S2212I","T2217I"],"S":["D178G"]},"labels":{"aa":"ORF1b: S2212I, T2217I; S: D178G","spike_mutations":"D178G"}}}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.361743927001953}},"branch_attrs":{"mutations":{"nuc":["C15324T"]}},"children":[{"name":"B.1.146","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.146"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.146"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["C10833T","G28747T","G28917T","G29543T"],"N":["G215V"],"ORF1a":["A3523V"]},"labels":{"aa":"N: G215V; ORF1a: A3523V"}}},{"name":"B.1.149","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.149"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.149"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.820753574371338}},"branch_attrs":{"mutations":{"nuc":["G16846T"],"ORF1b":["D1127Y"]},"labels":{"aa":"ORF1b: D1127Y"}}},{"name":"B.1.147","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.147"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.147"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.988577127456665}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"B.1.210","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.210"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.210"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.527066707611084}},"branch_attrs":{"mutations":{"nuc":["A1C","C3634T"]}}},{"name":"B.1.212","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.212"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.212"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.869997978210449}},"branch_attrs":{"mutations":{"nuc":["C16428T"]}}},{"name":"B.1.221","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.221"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.221"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.022772789001465}},"branch_attrs":{"mutations":{"nuc":["C3602T","C6941T","C21855T","A25505G","G25906C","G25996T","C28651T","C28869T"],"N":["P199L"],"ORF1a":["H1113Y"],"ORF3a":["Q38R","G172R","V202L"],"S":["S98F"]},"labels":{"aa":"N: P199L; ORF1a: H1113Y; ORF3a: Q38R, G172R, V202L; S: S98F","spike_mutations":"S98F"}}},{"name":"B.1.219","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.219"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.219"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.373951435089111}},"branch_attrs":{"mutations":{"nuc":["T13A","C16193T","A22404T"],"ORF1b":["P909L"],"S":["E281V"]},"labels":{"aa":"ORF1b: P909L; S: E281V","spike_mutations":"E281V"}}},{"name":"B.1.620","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.620"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.620"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A22T","C1473T","G6236A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G17110T","T20049C","C21638T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21939C","T21992-","A21993-","T21994-","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","C22295T","C22498T","G22992A","G23012A","A23416T","C23604A","C24642T","G24914C","A28271T","T28297C","C28932T"],"N":["A220V"],"ORF1a":["T403I","V1991I","S3675-","G3676-","F3677-"],"ORF1b":["A1215S"],"ORF9b":["I5T"],"S":["P26S","H69-","V70-","V126A","Y144-","L241-","L242-","A243-","H245Y","S477N","E484K","P681H","T1027I","D1118H"]},"labels":{"aa":"N: A220V; ORF1a: T403I, V1991I, S3675-, G3676-, F3677-; ORF1b: A1215S; ORF9b: I5T; S: P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H","spike_mutations":"P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H"}}},{"name":"NODE_0000471","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.518583297729492}},"branch_attrs":{"mutations":{"nuc":["A4457G","C5907T","C12312T"],"ORF1a":["I1398V","T1881I","A4016V"]},"labels":{"aa":"ORF1a: I1398V, T1881I, A4016V"}},"children":[{"name":"B.1.214","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.518583297729492}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000472","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-7.461870193481445}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.214.1","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-02"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.2221879959106445}},"branch_attrs":{"mutations":{"nuc":["A481G","C5144T","C17304G","C17999T"],"ORF1b":["T1511I"]},"labels":{"aa":"ORF1b: T1511I"}}},{"name":"NODE_0000473","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C4891T","A15187G","C23709T","T27576C","G28280C","A28281T","T28282A","C28846T"],"N":["D3L"],"ORF1b":["R574G"],"S":["T716I"]},"labels":{"aa":"N: D3L; ORF1b: R574G; S: T716I","spike_mutations":"T716I"}},"children":[{"name":"B.1.214.2","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:29-276"},"partiallyAliased":{"value":"B.1.214.2"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-02"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9553585052490234}},"branch_attrs":{"mutations":{"nuc":["C22802A","T22912G","A25448-","A25449-","A25450-","T25451-","C25452-","A25453-","A25454-","G25455-","G25456-","A25457-","T25458-","G25459-","C25460-","T25461-","A25462-","C25463-","T25464-","C25465-","C25466-","T25467-","T25468-","C25469-","A25470-","G25471-","A25472-","T25473-","T25474-","T25475-"],"ORF3a":["E19-","I20-","K21-","D22-","A23-","T24-","P25-","S26-","D27-","F28-"],"S":["Q414K","N450K"]},"labels":{"aa":"ORF3a: E19-, I20-, K21-, D22-, A23-, T24-, P25-, S26-, D27-, F28-; S: Q414K, N450K","spike_mutations":"Q414K, N450K"}}},{"name":"B.1.214.3","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-01"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C673T","A11282-","G11283-","T11284-","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291T","A11430G","C21846T"],"ORF1a":["S3673-","L3674-","S3675-","G3676C","Y3722C"],"S":["T95I"]},"labels":{"aa":"ORF1a: S3673-, L3674-, S3675-, G3676C, Y3722C; S: T95I","spike_mutations":"T95I"}}}]}]}]}]},{"name":"NODE_0000474","node_attrs":{"div":7,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-3.818593740463257}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","C28887T"],"N":["T205I"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: T205I; ORF1a: T265I; ORF3a: Q57H","clade":"20C"}},"children":[{"name":"B.1.346","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.346"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.346"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["A12820G","C16762T","A17637G","C20762T"],"ORF1b":["L1099F","T2432I"]},"labels":{"aa":"ORF1b: L1099F, T2432I"}}},{"name":"B.1.433","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.433"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.433"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.620072364807129}},"branch_attrs":{"mutations":{"nuc":["C6843T","T11764C","T17040C","G29402T"],"N":["D377Y"],"ORF1a":["S2193F"]},"labels":{"aa":"N: D377Y; ORF1a: S2193F"}}},{"name":"B.1.626","node_attrs":{"div":29,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.626"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.626"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-25"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1914A","C2197T","C9142T","C9803T","C10416T","C10908T","G11222T","C13011T","C16961T","C21614T","C21758-","A21759-","T21760-","G21761-","C21762-","T21763-","A21764-","T21765-","A21766-","G22331A","G23012A","T23031C","A23064C","C24138A","T24364C","C25511T","C25583T","T26767G","C27434T","A28271-","G28280T","C29627T","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"M":["I82S"],"N":["D3Y"],"ORF1a":["R550H","S3384L","A3548V","V3653F","T4249I"],"ORF1b":["P1165L"],"ORF3a":["S40L","T64I"],"ORF7a":["T14I"],"S":["L18F","H66-","A67-","I68-","G257S","E484K","F490S","N501T","T859N"]},"labels":{"aa":"M: I82S; N: D3Y; ORF1a: R550H, S3384L, A3548V, V3653F, T4249I; ORF1b: P1165L; ORF3a: S40L, T64I; ORF7a: T14I; S: L18F, H66-, A67-, I68-, G257S, E484K, F490S, N501T, T859N","spike_mutations":"L18F, H66-, A67-, I68-, G257S, E484K, F490S, N501T, T859N"}}},{"name":"NODE_0000475","node_attrs":{"div":8,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.235102653503418}},"branch_attrs":{"mutations":{"nuc":["G17259T"],"ORF1b":["E1264D"]},"labels":{"aa":"ORF1b: E1264D"}},"children":[{"name":"B.1.375","node_attrs":{"div":14,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.375"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.375"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.301670551300049}},"branch_attrs":{"mutations":{"nuc":["T1171C","A5747G","C10789T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G24007A","C25844T","A26664G"],"M":["I48V"],"ORF1a":["T1828A"],"ORF3a":["T151I"],"S":["H69-","V70-"]},"labels":{"aa":"M: I48V; ORF1a: T1828A; ORF3a: T151I; S: H69-, V70-","spike_mutations":"H69-, V70-"}}},{"name":"B.1.596.1","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.596.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.596.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["C21780T","G25907T","G28857A"],"N":["R195K"],"ORF3a":["G172V"],"S":["T73I"]},"labels":{"aa":"N: R195K; ORF3a: G172V; S: T73I","spike_mutations":"T73I"}}}]},{"name":"NODE_0000476","node_attrs":{"div":8,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.433472633361816}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"B.1.630","node_attrs":{"div":36,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.630"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.630"},"totalAminoacidDeletions":{"value":14},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-13"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C629T","A1262G","C1627T","G4963T","A5040G","A5648C","C6730T","C6794T","C7768T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T17505C","C19602T","G21255T","C21588T","C21637T","G21969T","T21992-","A21993-","T21994-","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22995G","G23012C","C23525T","G24410A","C25498-","C25499-","G25500-","A25501-","T25502-","A25503-","C25504-","A25505-","A25506-","G25507-","C25508-","C25509-","T25510-","C25511-","A25512-","C25513-","T25514-","C25515-","C25516-","C25517-","T25518-","T25519-","T25520-","C25521-","T25563G","T27796C","C27889T","A28272G","C28512G","G29508A","C29739T"],"N":["P80R","S412N"],"ORF1a":["L122F","T333A","R1566S","Q1592R","K1795Q","A3209V","S3675-","G3676-","F3677-"],"ORF3a":["P36-","I37-","Q38-","A39-","S40-","L41-","P42-","F43-","H57Q"],"ORF7b":["L14S"],"ORF9b":["Q77E"],"S":["P9L","C136F","Y144-","A222V","L242-","A243-","T478R","E484Q","H655Y","D950N"]},"labels":{"aa":"N: P80R, S412N; ORF1a: L122F, T333A, R1566S, Q1592R, K1795Q, A3209V, S3675-, G3676-, F3677-; ORF3a: P36-, I37-, Q38-, A39-, S40-, L41-, P42-, F43-, H57Q; ORF7b: L14S; ORF9b: Q77E; S: P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N","spike_mutations":"P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N"}}},{"name":"21C","node_attrs":{"div":13,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["G17014T","G21600T","G22018T","C26681T","A28272T"],"ORF1b":["D1183Y"],"S":["S13I","W152C"]},"labels":{"aa":"ORF1b: D1183Y; S: S13I, W152C","clade":"Epsilon","spike_mutations":"S13I, W152C"}},"children":[{"name":"B.1.429","node_attrs":{"div":20,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1.429"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.429"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-2.493906021118164}},"branch_attrs":{"mutations":{"nuc":["C2395T","T2597C","C8947T","C12100T","A12878G","T24349C","G27890T"],"ORF1a":["I4205V"]},"labels":{"aa":"ORF1a: I4205V"}}},{"name":"B.1.427","node_attrs":{"div":17,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1.427"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.427"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-2.8388144969940186}},"branch_attrs":{"mutations":{"nuc":["G9738C","G13713A","C16394T","C29362T"],"ORF1a":["S3158T"],"ORF1b":["P976L"]},"labels":{"aa":"ORF1a: S3158T; ORF1b: P976L"}}}]}]},{"name":"NODE_0000478","node_attrs":{"div":18,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.885955572128296}},"branch_attrs":{"mutations":{"nuc":["G174T","G5230T","A10323G","A21801C","A22206G","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","G22813T","G23012A","A23063T","C23664T","C26456T","C28253T"],"E":["P71L"],"ORF1a":["K1655N","K3353R"],"S":["D80A","D215G","L241-","L242-","A243-","K417N","E484K","N501Y","A701V"]},"labels":{"aa":"E: P71L; ORF1a: K1655N, K3353R; S: D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V","clade":"Beta","spike_mutations":"D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V"}},"children":[{"name":"B.1.351.1","node_attrs":{"div":27,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-5.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["C11289G","G11291T","G11292A","T11293C","G11299T","C11300T","T11301A","A11302C","C22513A"],"ORF1a":["S3675C","G3676Y","K3678N","L3679Y"],"S":["N317K"]},"labels":{"aa":"ORF1a: S3675C, G3676Y, K3678N, L3679Y; S: N317K","spike_mutations":"N317K"}}},{"name":"NODE_0000479","node_attrs":{"div":19,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.237952470779419}},"branch_attrs":{"mutations":{"nuc":["C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}},"children":[{"name":"B.1.351","node_attrs":{"div":19,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.237952470779419}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000480","node_attrs":{"div":21,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-2.969865322113037}},"branch_attrs":{"mutations":{"nuc":["A2692T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C21614T"],"ORF1a":["S3675-","G3676-","F3677-"],"S":["L18F"]},"labels":{"aa":"ORF1a: S3675-, G3676-, F3677-; S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.351.5","node_attrs":{"div":31,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.5"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-20"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-4.056198596954346}},"branch_attrs":{"mutations":{"nuc":["C664T","G1463T","C16338T","C19019A","C24109T","C24334T","G25660A","C25844T","C26645T","A29406T"],"N":["E378V"],"ORF1a":["G400C"],"ORF1b":["P1851Q"],"ORF3a":["V90I","T151I"]},"labels":{"aa":"N: E378V; ORF1a: G400C; ORF1b: P1851Q; ORF3a: V90I, T151I"}}},{"name":"NODE_0000481","node_attrs":{"div":23,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A8052G","G10396T"],"ORF1a":["N2596S"]},"labels":{"aa":"ORF1a: N2596S"}},"children":[{"name":"B.1.351.2","node_attrs":{"div":24,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.2"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C10632T"],"ORF1a":["A3456V"]},"labels":{"aa":"ORF1a: A3456V"}}},{"name":"B.1.351.3","node_attrs":{"div":28,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.3"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-05"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-4.0184102058410645}},"branch_attrs":{"mutations":{"nuc":["T3G","C6402T","T7624C","C10615T","A16687G"],"ORF1a":["P2046L"],"ORF1b":["I1074V"]},"labels":{"aa":"ORF1a: P2046L; ORF1b: I1074V"}}}]}]}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":11,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.10436749458313}},"branch_attrs":{"mutations":{"nuc":["T445C","C6286T","G21255C","C22227T","C26801G","C28932T","G29645T"],"N":["A220V"],"S":["A222V"]},"labels":{"aa":"N: A220V; S: A222V","clade":"20E","spike_mutations":"A222V"}},"children":[{"name":"B.1.177","node_attrs":{"div":11,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.10436749458313}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.16","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.051562786102295}},"branch_attrs":{"mutations":{"nuc":["C28310A"],"N":["P13T"],"ORF9b":["H9Q"]},"labels":{"aa":"N: P13T; ORF9b: H9Q"}}},{"name":"B.1.177.18","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.176742076873779}},"branch_attrs":{"mutations":{"nuc":["A10323G","G23311C","G25440T","C27752T"],"ORF1a":["K3353R"],"ORF3a":["K16N"],"ORF7a":["T120I"],"S":["E583D"]},"labels":{"aa":"ORF1a: K3353R; ORF3a: K16N; ORF7a: T120I; S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.177.15","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.15"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.15"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.8122081756591797}},"branch_attrs":{"mutations":{"nuc":["C5170T","C10078T","G11132T","G11417T","G22051T","G29179T"],"ORF1a":["A3623S","V3718F"]},"labels":{"aa":"ORF1a: A3623S, V3718F"}}},{"name":"B.1.177.32","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.32"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.204561233520508}},"branch_attrs":{"mutations":{"nuc":["C5700T","C11152T"],"ORF1a":["A1812V"]},"labels":{"aa":"ORF1a: A1812V"}}},{"name":"B.1.177.73","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.73"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.0868425369262695}},"branch_attrs":{"mutations":{"nuc":["G1820A","A2473G","T7543C","C13671T","A24774T","C26060A"],"ORF1a":["G519S"],"ORF3a":["T223N"],"S":["Q1071L"]},"labels":{"aa":"ORF1a: G519S; ORF3a: T223N; S: Q1071L","spike_mutations":"Q1071L"}}},{"name":"B.1.177.75","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.75"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.15676212310791}},"branch_attrs":{"mutations":{"nuc":["A1C","T8284C"]}}},{"name":"NODE_0000483","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.143002986907959}},"branch_attrs":{"mutations":{"nuc":["C222T","T20661C","C29386T"]}},"children":[{"name":"B.1.177.44","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.44"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.074657917022705}},"branch_attrs":{"mutations":{"nuc":["G21468T"],"ORF1b":["M2667I"]},"labels":{"aa":"ORF1b: M2667I"}}},{"name":"NODE_0000484","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.473905324935913}},"branch_attrs":{"mutations":{"nuc":["C29366T"],"N":["P365S"]},"labels":{"aa":"N: P365S"}},"children":[{"name":"B.1.177.12","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.12"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.12"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.395730495452881}},"branch_attrs":{"mutations":{"nuc":["T24814C","G25757T"],"ORF3a":["R122I"]},"labels":{"aa":"ORF3a: R122I"}}},{"name":"B.1.177.35","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.877903938293457}},"branch_attrs":{"mutations":{"nuc":["T26966C"]}}}]}]},{"name":"NODE_0000485","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.9249725341796875}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}},"children":[{"name":"B.1.177.10","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.106119155883789}},"branch_attrs":{"mutations":{"nuc":["G28321A"],"ORF9b":["R13H"]},"labels":{"aa":"ORF9b: R13H"}}},{"name":"B.1.177.46","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.46"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.155553817749023}},"branch_attrs":{"mutations":{"nuc":["C9693T","C18508T","G29179T"],"ORF1a":["A3143V"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: A3143V; ORF1b: L1681F"}}},{"name":"NODE_0000486","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.44374942779541}},"branch_attrs":{"mutations":{"nuc":["C1513T","C22377T"],"S":["P272L"]},"labels":{"aa":"S: P272L","spike_mutations":"P272L"}},"children":[{"name":"B.1.177.82","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.82"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.837984561920166}},"branch_attrs":{"mutations":{"nuc":["G28378T","G29757T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.177.83","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.83"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.299724102020264}},"branch_attrs":{"mutations":{"nuc":["C2062T"]}}},{"name":"B.1.177.87","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.87"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.936094045639038}},"branch_attrs":{"mutations":{"nuc":["C28706T","C29095T"],"N":["H145Y"]},"labels":{"aa":"N: H145Y"}}}]}]},{"name":"NODE_0000487","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.161720037460327}},"branch_attrs":{"mutations":{"nuc":["C27944T"]}},"children":[{"name":"B.1.177.4","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.478666067123413}},"branch_attrs":{"mutations":{"nuc":["C66T","A1987G","G10870T","C25614T"]}}},{"name":"B.1.177.52","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.52"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.295442581176758}},"branch_attrs":{"mutations":{"nuc":["A1T","G5023T","C25047G"],"ORF1a":["M1586I"],"S":["P1162R"]},"labels":{"aa":"ORF1a: M1586I; S: P1162R","spike_mutations":"P1162R"}}},{"name":"B.1.177.81","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.81"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.399031639099121}},"branch_attrs":{"mutations":{"nuc":["C12119T","A21222T","C25889T"],"ORF1a":["P3952S"],"ORF3a":["S166L"]},"labels":{"aa":"ORF1a: P3952S; ORF3a: S166L"}}},{"name":"NODE_0000488","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.53"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.278008460998535}},"branch_attrs":{"mutations":{"nuc":["C2973T","G9805T"],"ORF1a":["A903V"]},"labels":{"aa":"ORF1a: A903V"}},"children":[{"name":"B.1.177.53","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.53"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.278008460998535}},"branch_attrs":{"mutations":{}}},{"name":"W.1","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"W.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.53.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-5.000475883483887}},"branch_attrs":{"mutations":{"nuc":["C17463T","C17676T","T24799C","G25785T"],"ORF3a":["W131C"]},"labels":{"aa":"ORF3a: W131C"}}}]},{"name":"NODE_0000489","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.131291389465332}},"branch_attrs":{"mutations":{"nuc":["G204T"]}},"children":[{"name":"B.1.177.21","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.21"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.21"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.0787036418914795}},"branch_attrs":{"mutations":{"nuc":["T16242A"]}}},{"name":"B.1.177.77","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.77"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.045211315155029}},"branch_attrs":{"mutations":{"nuc":["T3592C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"NODE_0000490","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.644140243530273}},"branch_attrs":{"mutations":{"nuc":["C9745T"]}},"children":[{"name":"B.1.177.54","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.54"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.9744465351104736}},"branch_attrs":{"mutations":{"nuc":["C23644T","T25878C","G25879A","A25881T"],"ORF3a":["V163I"]},"labels":{"aa":"ORF3a: V163I"}}},{"name":"NODE_0000491","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.353252410888672}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"ORF1a":["A2554V"]},"labels":{"aa":"ORF1a: A2554V"}},"children":[{"name":"B.1.177.56","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.56"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.353252410888672}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.57","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.57"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.707308292388916}},"branch_attrs":{"mutations":{"nuc":["C6807T"],"ORF1a":["T2181I"]},"labels":{"aa":"ORF1a: T2181I"}}}]}]},{"name":"NODE_0000492","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-2.56699800491333}},"branch_attrs":{"mutations":{"nuc":["C21614T"],"S":["L18F"]},"labels":{"aa":"S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.177.5","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.151096820831299}},"branch_attrs":{"mutations":{"nuc":["T24769C","C25460T"],"ORF3a":["A23V"]},"labels":{"aa":"ORF3a: A23V"}}},{"name":"B.1.177.60","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.60"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.3496036529541016}},"branch_attrs":{"mutations":{"nuc":["A1G","G25621T"],"ORF3a":["V77F"]},"labels":{"aa":"ORF3a: V77F"}}},{"name":"B.1.177.62","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.62"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.26824951171875}},"branch_attrs":{"mutations":{"nuc":["C7195T","C21714T","G24368T","G25855T"],"ORF3a":["D155Y"],"S":["T51I","D936Y"]},"labels":{"aa":"ORF3a: D155Y; S: T51I, D936Y","spike_mutations":"T51I, D936Y"}}},{"name":"B.1.177.7","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.7"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.4441723823547363}},"branch_attrs":{"mutations":{"nuc":["C15480T"]}}},{"name":"B.1.177.8","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.112912654876709}},"branch_attrs":{"mutations":{"nuc":["G8179T"]}}},{"name":"B.1.177.86","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.86"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.4548091888427734}},"branch_attrs":{"mutations":{"nuc":["C6040T","G26801T","G27870T"],"ORF7b":["E39*"]},"labels":{"aa":"ORF7b: E39*"}}}]}]}]}]},{"name":"NODE_0000493","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.2655062675476074}},"branch_attrs":{"mutations":{"nuc":["A20268G"]}},"children":[{"name":"B.1.189","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.189"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.189"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0477776527404785}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.192","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.192"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.192"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.362252235412598}},"branch_attrs":{"mutations":{"nuc":["C11833T"]}}},{"name":"B.1.237","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.237"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.237"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.8359174728393555}},"branch_attrs":{"mutations":{"nuc":["G2164C"],"ORF1a":["E633D"]},"labels":{"aa":"ORF1a: E633D"}}},{"name":"B.1.381","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.381"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.381"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.034161567687988}},"branch_attrs":{"mutations":{"nuc":["C355T","C4093T"]}}},{"name":"B.1.420","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.420"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.420"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.049466133117676}},"branch_attrs":{"mutations":{"nuc":["T23443C"]}}},{"name":"B.1.417","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.417"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.417"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.064149856567383}},"branch_attrs":{"mutations":{"nuc":["T5422C","C7051T","G7743T","C12880T"],"ORF1a":["S2493I"]},"labels":{"aa":"ORF1a: S2493I"}}},{"name":"B.1.609","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.609"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.609"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.865211248397827}},"branch_attrs":{"mutations":{"nuc":["C4582T"]}}},{"name":"B.1.600","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.600"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.600"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.995730876922607}},"branch_attrs":{"mutations":{"nuc":["A5G","A6G","G7A","C5784T","C27982T"],"ORF1a":["T1840I"],"ORF8":["P30L"]},"labels":{"aa":"ORF1a: T1840I; ORF8: P30L"}}},{"name":"NODE_0000494","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.637956142425537}},"branch_attrs":{"mutations":{"nuc":["A1C","C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}},"children":[{"name":"B.1.416","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.416"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.27862024307251}},"branch_attrs":{"mutations":{"nuc":["C1625T"],"ORF1a":["L454F"]},"labels":{"aa":"ORF1a: L454F"}}},{"name":"B.1.416.1","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.416.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.302814483642578}},"branch_attrs":{"mutations":{"nuc":["C25731T"]}}}]},{"name":"NODE_0000495","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{"nuc":["A1G","T7767C","C8047T","C17104T","C22879A","G29734C"],"ORF1a":["I2501T"],"ORF1b":["H1213Y"],"S":["N439K"]},"labels":{"aa":"ORF1a: I2501T; ORF1b: H1213Y; S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.258","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{}}},{"name":"B.1.258.3","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9645659923553467}},"branch_attrs":{"mutations":{"nuc":["G1464A","A10978T","G18803T","T20799C"],"ORF1a":["G400D"],"ORF1b":["S1779I"]},"labels":{"aa":"ORF1a: G400D; ORF1b: S1779I"}}},{"name":"NODE_0000496","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9934825897216797}},"branch_attrs":{"mutations":{"nuc":["C27800A"]}},"children":[{"name":"B.1.258.14","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.14"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.14"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.224915027618408}},"branch_attrs":{"mutations":{"nuc":["G1A","C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}}},{"name":"NODE_0000497","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.193143367767334}},"branch_attrs":{"mutations":{"nuc":["G12988T","G15598A","G18028T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T24910C","T26972C"],"ORF1a":["M4241I"],"ORF1b":["V711I","A1521S"],"S":["H69-","V70-"]},"labels":{"aa":"ORF1a: M4241I; ORF1b: V711I, A1521S; S: H69-, V70-","spike_mutations":"H69-, V70-"}},"children":[{"name":"B.1.258.11","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.11"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.11"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.367208242416382}},"branch_attrs":{"mutations":{"nuc":["C12455T","C20451T"],"ORF1a":["L4064F"]},"labels":{"aa":"ORF1a: L4064F"}}},{"name":"B.1.258.17","node_attrs":{"div":25,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.17"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.17"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.194498300552368}},"branch_attrs":{"mutations":{"nuc":["C829T","C14697T","C16394T","C18176T","G19398T","C22127T","G23876A","G25947T"],"ORF1b":["P976L","P1570L","E1977D"],"ORF3a":["Q185H"],"S":["L189F","V772I"]},"labels":{"aa":"ORF1b: P976L, P1570L, E1977D; ORF3a: Q185H; S: L189F, V772I","spike_mutations":"L189F, V772I"}}}]}]}]},{"name":"NODE_0000498","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0564932823181152}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.232","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.232"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.232"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8151824474334717}},"branch_attrs":{"mutations":{"nuc":["G27987T"],"ORF8":["V32L"]},"labels":{"aa":"ORF8: V32L"}}},{"name":"B.1.236","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.236"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.236"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.487241744995117}},"branch_attrs":{"mutations":{"nuc":["G11842A","A12759G","G18292T"],"ORF1a":["D4165G"],"ORF1b":["A1609S"]},"labels":{"aa":"ORF1a: D4165G; ORF1b: A1609S"}}},{"name":"B.1.234","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.234"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.234"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.2366039752960205}},"branch_attrs":{"mutations":{"nuc":["G2258A","A6441G","C8140T","A9204G"],"ORF1a":["V665I","K2059R","D2980G"]},"labels":{"aa":"ORF1a: V665I, K2059R, D2980G"}}},{"name":"B.1.239","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.239"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.239"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.171220779418945}},"branch_attrs":{"mutations":{"nuc":["G16741A"],"ORF1b":["V1092I"]},"labels":{"aa":"ORF1b: V1092I"}}},{"name":"B.1.243","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.243"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.243"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.002568006515503}},"branch_attrs":{"mutations":{"nuc":["T24076C"]}}},{"name":"B.1.241","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.241"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.241"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9270756244659424}},"branch_attrs":{"mutations":{"nuc":["C11575T"]}}},{"name":"B.1.398","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.398"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.398"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.523491859436035}},"branch_attrs":{"mutations":{"nuc":["G4136A","C11224T","C12295A","C21846T"],"ORF1a":["V1291I"],"S":["T95I"]},"labels":{"aa":"ORF1a: V1291I; S: T95I","spike_mutations":"T95I"}}},{"name":"B.1.396","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.396"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.396"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1255927085876465}},"branch_attrs":{"mutations":{"nuc":["C1191T","C9521A","C24904T","G29422T","A29567G"],"ORF1a":["P309L","L3086I"]},"labels":{"aa":"ORF1a: P309L, L3086I"}}},{"name":"B.1.397","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.397"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.397"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.8025803565979}},"branch_attrs":{"mutations":{"nuc":["G1135T"],"ORF1a":["K290N"]},"labels":{"aa":"ORF1a: K290N"}}},{"name":"B.1.400","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.400"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.400"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.656111001968384}},"branch_attrs":{"mutations":{"nuc":["G19969A"],"ORF1b":["A2168T"]},"labels":{"aa":"ORF1b: A2168T"}}},{"name":"B.1.399","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.399"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.399"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.259310722351074}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}}},{"name":"B.1.409","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.409"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.409"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.119840621948242}},"branch_attrs":{"mutations":{"nuc":["G3527A","G5015A","A5877G","G8017T","C11008T","C20283T","C25714T","G25855T","C27434T","C27998T"],"ORF1a":["D1088N","V1584M","N1871S"],"ORF3a":["L108F","D155Y"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: D1088N, V1584M, N1871S; ORF3a: L108F, D155Y; ORF7a: T14I"}}},{"name":"B.1.402","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.402"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.402"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0817766189575195}},"branch_attrs":{"mutations":{"nuc":["C4633T","T14643C","C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"B.1.551","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.551"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.551"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.050684928894043}},"branch_attrs":{"mutations":{"nuc":["C3738T","C23604G"],"ORF1a":["P1158L"],"S":["P681R"]},"labels":{"aa":"ORF1a: P1158L; S: P681R","spike_mutations":"P681R"}}},{"name":"B.1.558","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.558"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.558"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.163711071014404}},"branch_attrs":{"mutations":{"nuc":["C1288T"]}}},{"name":"NODE_0000499","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6818833351135254}},"branch_attrs":{"mutations":{"nuc":["C18486T","T22162C"]}},"children":[{"name":"B.1.240","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.240"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6818833351135254}},"branch_attrs":{"mutations":{}}},{"name":"B.1.240.1","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.240.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-8.3259916305542}},"branch_attrs":{"mutations":{"nuc":["G10610T","G10870T","G11335T","C14262T","G29494A"],"ORF1a":["V3449F"]},"labels":{"aa":"ORF1a: V3449F"}}}]},{"name":"NODE_0000500","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.489668369293213}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"B.1.404","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.404"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.404"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["G5572T","G7042T","A12644G","T16743C","G19086T","G22992A"],"ORF1a":["M1769I","M2259I","I4127V"],"ORF1b":["K1873N"],"S":["S477N"]},"labels":{"aa":"ORF1a: M1769I, M2259I, I4127V; ORF1b: K1873N; S: S477N","spike_mutations":"S477N"}}},{"name":"B.1.561","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.561"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.561"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6974472999572754}},"branch_attrs":{"mutations":{"nuc":["G2516T","A5999G","C18693T","G21974T","T25577C","G28975T"],"N":["M234I"],"ORF1a":["V751L","I1912V"],"ORF3a":["I62T"],"S":["D138Y"]},"labels":{"aa":"N: M234I; ORF1a: V751L, I1912V; ORF3a: I62T; S: D138Y","spike_mutations":"D138Y"}}}]}]}]},{"name":"NODE_0000501","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.725203275680542}},"branch_attrs":{"mutations":{"nuc":["C18877T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.111","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.111"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.111"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.209517478942871}},"branch_attrs":{"mutations":{"nuc":["C10507T"]}}},{"name":"B.1.170","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.170"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.170"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.725203275680542}},"branch_attrs":{"mutations":{}}},{"name":"B.1.436","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.436"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.436"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.123165607452393}},"branch_attrs":{"mutations":{"nuc":["C28890T","T29710A"],"N":["S206F"]},"labels":{"aa":"N: S206F"}}},{"name":"B.1.438","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.438"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.438"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.653039455413818}},"branch_attrs":{"mutations":{"nuc":["A1154G","G29474T"],"N":["D401Y"],"ORF1a":["M297V"]},"labels":{"aa":"N: D401Y; ORF1a: M297V"}}},{"name":"B.1.441","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.441"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.441"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.796085357666016}},"branch_attrs":{"mutations":{"nuc":["T8296C","G28690T"],"N":["L139F"]},"labels":{"aa":"N: L139F"}}},{"name":"NODE_0000502","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.096360206604004}},"branch_attrs":{"mutations":{"nuc":["A28272G","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}},"children":[{"name":"B.1.438.1","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.438.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.438.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.225435256958008}},"branch_attrs":{"mutations":{"nuc":["A1154G","C8152T","A12121G","G23587T","G25677T","G29474T"],"N":["D401Y"],"ORF1a":["M297V"],"ORF3a":["L95F"],"S":["Q675H"]},"labels":{"aa":"N: D401Y; ORF1a: M297V; ORF3a: L95F; S: Q675H","spike_mutations":"Q675H"}}},{"name":"B.1.625","node_attrs":{"div":26,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.625"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:4-122"},"partiallyAliased":{"value":"B.1.625"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-19"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["G521T","C2306T","A4220G","C5730T","C6401T","A10323G","C10775T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12730G","A13712G","C16694T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","T21992-","A21993-","T21994-","C22033A","T22882G","G23012A","G24410A","G25244T","T26767C","A27721G","A27897-","A27898-","A27899-","T27900-","T27901-"],"M":["I82T"],"ORF1a":["V86F","L681F","K1319E","T1822I","P2046S","K3353R","P3504S","S3675-","G3676-","F3677-"],"ORF1b":["K82R","T1076I"],"ORF7a":["I110V"],"ORF8":["K2-","F3-"],"S":["H69-","V70-","T95I","Y144-","F157L","N440K","E484K","D950N","V1228L"]},"labels":{"aa":"M: I82T; ORF1a: V86F, L681F, K1319E, T1822I, P2046S, K3353R, P3504S, S3675-, G3676-, F3677-; ORF1b: K82R, T1076I; ORF7a: I110V; ORF8: K2-, F3-; S: H69-, V70-, T95I, Y144-, F157L, N440K, E484K, D950N, V1228L","spike_mutations":"H69-, V70-, T95I, Y144-, F157L, N440K, E484K, D950N, V1228L"}}}]},{"name":"NODE_0000503","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.250260353088379}},"branch_attrs":{"mutations":{"nuc":["C7765T","C17690T"],"ORF1b":["S1408L"]},"labels":{"aa":"ORF1b: S1408L"}},"children":[{"name":"B.1.9.5","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.9.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.250260353088379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.9","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.9"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.655849933624268}},"branch_attrs":{"mutations":{"nuc":["C2113T"]}}}]},{"name":"NODE_0000504","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.290716171264648}},"branch_attrs":{"mutations":{"nuc":["C10029T","A21993-","A23063T","C23604A","A26492T","C28887T"],"N":["T205I"],"ORF1a":["T3255I"],"S":["Y144-","N501Y","P681H"]},"labels":{"aa":"N: T205I; ORF1a: T3255I; S: Y144-, N501Y, P681H","spike_mutations":"Y144-, N501Y, P681H"}},"children":[{"name":"B.1.640.1","node_attrs":{"div":46,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.640.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.640.1"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C601T","C1191T","A1620G","C2416T","C2455T","G6622T","C9711T","G9756A","T11418C","C11956T","C16575T","C16869T","T18877C","C20283T","C21588T","G21848C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","T21994-","G22132T","T22191C","A22600C","A22743G","T22907A","T23030C","T23031G","C24138A","G24368C","C25487T","T26767C","C27513T","C27807T","C27972T","A28271-","T28297C","G28337T","T29377C","G29405C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","G29779T"],"M":["I82T"],"N":["D22Y","E378Q"],"ORF1a":["P309L","E452G","L2119F","S3149F","R3164H","V3718A"],"ORF3a":["T32I"],"ORF8":["Q27*"],"ORF9b":["I5T","Q18H"],"S":["P9L","E96Q","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","R190S","I210T","R346S","N394S","Y449N","F490R","T859N","D936H"]},"labels":{"aa":"M: I82T; N: D22Y, E378Q; ORF1a: P309L, E452G, L2119F, S3149F, R3164H, V3718A; ORF3a: T32I; ORF8: Q27*; ORF9b: I5T, Q18H; S: P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, R190S, I210T, R346S, N394S, Y449N, F490R, T859N, D936H","spike_mutations":"P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, R190S, I210T, R346S, N394S, Y449N, F490R, T859N, D936H"}}},{"name":"NODE_0000505","node_attrs":{"div":29,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-3.4022557735443115}},"branch_attrs":{"mutations":{"nuc":["A3428G","C4878T","C6037T","A11451G","A13057T","C17491T","T19035C","C20148T","C21846T","-21993C","T21995A","G22599A","G23012A","G24410A","G26158-","T26159-","T26160-","A26161-","C27925A","C28005T","C28093T","A28272T"],"ORF1a":["T1055A","T1538I","Q3729R"],"ORF1b":["P1342S"],"ORF3a":["V256-","N257-"],"ORF8":["T11K","P38S","S67F"],"S":["T95I","-144S","Y145N","R346K","E484K","D950N"]},"labels":{"aa":"ORF1a: T1055A, T1538I, Q3729R; ORF1b: P1342S; ORF3a: V256-, N257-; ORF8: T11K, P38S, S67F; S: T95I, -144S, Y145N, R346K, E484K, D950N","clade":"Mu","spike_mutations":"T95I, -144S, Y145N, R346K, E484K, D950N"}},"children":[{"name":"B.1.621","node_attrs":{"div":29,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-23"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-3.4022557735443115}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":31,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.116074562072754}},"branch_attrs":{"mutations":{"nuc":["C5192T","C17707T"],"ORF1b":["P1414S"]},"labels":{"aa":"ORF1b: P1414S"}},"children":[{"name":"B.1.621.2","node_attrs":{"div":39,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-05"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["T177C","C2700T","T22907A","G23311T","G26959A","A27675C","G29736A","G29779T"],"M":["R146H"],"ORF1a":["T812I"],"ORF7a":["Q94H"],"S":["Y449N","E583D"]},"labels":{"aa":"M: R146H; ORF1a: T812I; ORF7a: Q94H; S: Y449N, E583D","spike_mutations":"Y449N, E583D"}}},{"name":"NODE_0000507","node_attrs":{"div":38,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.1"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{"nuc":["A6704G","C9120T","C20402T","T22384A","G26167T","C28657T","T29748C"],"ORF1a":["N2147D","T2952I"],"ORF1b":["S2312L"]},"labels":{"aa":"ORF1a: N2147D, T2952I; ORF1b: S2312L"}},"children":[{"name":"B.1.621.1","node_attrs":{"div":38,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.1"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-30"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{}}},{"name":"BB.2","node_attrs":{"div":42,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"BB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.1.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A6708G","C15963T","C24378T","C29409T"],"N":["T379I"],"ORF1a":["K2148R"],"S":["S939F"]},"labels":{"aa":"N: T379I; ORF1a: K2148R; S: S939F","spike_mutations":"S939F"}}}]}]}]}]},{"name":"NODE_0000508","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0052971839904785}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}},"children":[{"name":"B.1.465","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.465"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.465"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.766111373901367}},"branch_attrs":{"mutations":{"nuc":["G24197T"],"S":["A879S"]},"labels":{"aa":"S: A879S","spike_mutations":"A879S"}}},{"name":"B.1.462","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.462"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.462"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.589012622833252}},"branch_attrs":{"mutations":{"nuc":["C3811T"]}}},{"name":"B.1.468","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.468"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.468"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.633845806121826}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}}},{"name":"B.1.470","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.470"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.470"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.864387512207031}},"branch_attrs":{"mutations":{"nuc":["C14120T"],"ORF1b":["P218L"]},"labels":{"aa":"ORF1b: P218L"}}},{"name":"B.1.471","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.471"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.471"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.839450836181641}},"branch_attrs":{"mutations":{"nuc":["C16915T","T24202C"]}}},{"name":"B.1.469","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.469"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.469"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.699270725250244}},"branch_attrs":{"mutations":{"nuc":["A12075G","A21137G","C28866T"],"N":["T198I"],"ORF1a":["N3937S"],"ORF1b":["K2557R"]},"labels":{"aa":"N: T198I; ORF1a: N3937S; ORF1b: K2557R"}}},{"name":"B.1.523","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.523"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.523"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.353262901306152}},"branch_attrs":{"mutations":{"nuc":["G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"NODE_0000509","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.896757125854492}},"branch_attrs":{"mutations":{"nuc":["C4543T","G5629T","G9526T","C11497T","G13993T","G15766T","A16889G","G17019T","G22992A","C25710T","T26876C","G28975C","G29399A"],"N":["M234I","A376T"],"ORF1a":["M3087I"],"ORF1b":["A176S","V767L","K1141R","E1184D"],"S":["S477N"]},"labels":{"aa":"N: M234I, A376T; ORF1a: M3087I; ORF1b: A176S, V767L, K1141R, E1184D; S: S477N","spike_mutations":"S477N"}},"children":[{"name":"B.1.160","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.160"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.896757125854492}},"branch_attrs":{"mutations":{}}},{"name":"B.1.160.16","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.160.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.024462699890137}},"branch_attrs":{"mutations":{"nuc":["C27434T","C27964T","G29557T"],"ORF7a":["T14I"],"ORF8":["S24L"]},"labels":{"aa":"ORF7a: T14I; ORF8: S24L"}}}]},{"name":"NODE_0000510","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.83497428894043}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.466.1","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["A3423G","C6318A","C15026T","A19960G","C22879A","G25526T","C25553T","C26111T","A29019G","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K249R"],"ORF1a":["K1053R","P2018Q"],"ORF1b":["A520V","T2165A"],"ORF3a":["W45L","A54V","P240L"],"S":["N439K"]},"labels":{"aa":"N: K249R; ORF1a: K1053R, P2018Q; ORF1b: A520V, T2165A; ORF3a: W45L, A54V, P240L; S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.466","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.83497428894043}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000511","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.037178993225098}},"branch_attrs":{"mutations":{"nuc":["C5184T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"B.1.459","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.459"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.459"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.037178993225098}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000512","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.371043682098389}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22879A","C28887T"],"N":["T205I"],"ORF1a":["T1168I"],"S":["N439K"]},"labels":{"aa":"N: T205I; ORF1a: T1168I; S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.466.2","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.371043682098389}},"branch_attrs":{"mutations":{"nuc":["A29897T","A29898G","A29899G","A29902G"]}}},{"name":"NODE_0000513","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7382190227508545}},"branch_attrs":{"mutations":{"nuc":["C683T","C3096T","C11195T","C12880T","C17012T","T22219C","C23604G","C29718T","C29743T"],"ORF1a":["S944L","L3644F"],"ORF1b":["S1182L"],"S":["P681R"]},"labels":{"aa":"ORF1a: S944L, L3644F; ORF1b: S1182L; S: P681R","spike_mutations":"P681R"}},"children":[{"name":"AU.2","node_attrs":{"div":24,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"AU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-30"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.538212776184082}},"branch_attrs":{"mutations":{"nuc":["A11117G","C12439T","G20002T","G25314T"],"ORF1a":["I3618V"],"ORF1b":["D2179Y"],"S":["G1251V"]},"labels":{"aa":"ORF1a: I3618V; ORF1b: D2179Y; S: G1251V","spike_mutations":"G1251V"}}},{"name":"AU.3","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"AU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-30"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.585629463195801}},"branch_attrs":{"mutations":{"nuc":["C8109T","C19586T","G29315C"],"N":["D348H"],"ORF1a":["T2615I"],"ORF1b":["T2040I"]},"labels":{"aa":"N: D348H; ORF1a: T2615I; ORF1b: T2040I"}}}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.642129898071289}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36.19","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.19"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.19"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.078061103820801}},"branch_attrs":{"mutations":{"nuc":["A1C","G28086T","C29614T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"B.1.456","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.456"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.456"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.642129898071289}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000515","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}},"children":[{"name":"B.1.36","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.1","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.350651741027832}},"branch_attrs":{"mutations":{"nuc":["C11224T","C11941T","C12043T"]}}},{"name":"B.1.36.10","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.16","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.127452373504639}},"branch_attrs":{"mutations":{"nuc":["A1T","G25494T"]}}},{"name":"B.1.36.22","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.22"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.22"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1283345222473145}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"B.1.36.29","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.29"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8214738368988037}},"branch_attrs":{"mutations":{"nuc":["C3267T","C21034T","G26173T","G28183T","T28277C"],"N":["S2P"],"ORF1a":["T1001I"],"ORF1b":["L2523F"],"ORF3a":["E261*"],"ORF8":["S97I"]},"labels":{"aa":"N: S2P; ORF1a: T1001I; ORF1b: L2523F; ORF3a: E261*; ORF8: S97I"}}},{"name":"B.1.36.24","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.24"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.24"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.737071990966797}},"branch_attrs":{"mutations":{"nuc":["G22201T"]}}},{"name":"B.1.36.31","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.31"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1722T","A8512G","T9877C","G11222T","C12616T","C15738T","A21868T","C22227T","C25463T","G27561T","C28253T","C29095T"],"ORF1a":["A486V","V3653F"],"ORF3a":["T24I"],"S":["R102S","A222V"]},"labels":{"aa":"ORF1a: A486V, V3653F; ORF3a: T24I; S: R102S, A222V","spike_mutations":"R102S, A222V"}}},{"name":"B.1.36.35","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.654303073883057}},"branch_attrs":{"mutations":{"nuc":["G25440T"],"ORF3a":["K16N"]},"labels":{"aa":"ORF3a: K16N"}}},{"name":"B.1.36.7","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.7"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.544944763183594}},"branch_attrs":{"mutations":{"nuc":["A11211G","A22190-","T22191-","T22192-"],"ORF1a":["Y3649C"],"S":["I210-"]},"labels":{"aa":"ORF1a: Y3649C; S: I210-","spike_mutations":"I210-"}}},{"name":"B.1.36.8","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.073090076446533}},"branch_attrs":{"mutations":{"nuc":["A1T","C2836T"]}}},{"name":"B.1.36.9","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.9"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.9"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["G2035T","C2523T","G3994A","C5730T","C9924T","G11083T","C11109T","A22190-","T22191-","T22192-","C24138A"],"ORF1a":["L590F","T753I","T1822I","A3220V","L3606F","A3615V"],"S":["I210-","T859N"]},"labels":{"aa":"ORF1a: L590F, T753I, T1822I, A3220V, L3606F, A3615V; S: I210-, T859N","spike_mutations":"I210-, T859N"}}},{"name":"NODE_0000516","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.4276256561279297}},"branch_attrs":{"mutations":{"nuc":["T1947C"],"ORF1a":["V561A"]},"labels":{"aa":"ORF1a: V561A"}},"children":[{"name":"B.1.36.36","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8934714794158936}},"branch_attrs":{"mutations":{"nuc":["C2668T","G4136T","C12141T","C19512T","C28292A","G29179T"],"N":["Q7K"],"ORF1a":["V1291F","T3959I"]},"labels":{"aa":"N: Q7K; ORF1a: V1291F, T3959I"}}},{"name":"B.1.36.38","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.38"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.2723917961120605}},"branch_attrs":{"mutations":{"nuc":["G22918T"]}}},{"name":"NODE_0000517","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.259945392608643}},"branch_attrs":{"mutations":{"nuc":["C29555T"]}},"children":[{"name":"B.1.36.18","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8423047065734863}},"branch_attrs":{"mutations":{"nuc":["G8027T","G15438T","C18981T","G21785C","C28093T"],"ORF1a":["V2588F"],"ORF1b":["M657I"],"ORF8":["S67F"],"S":["G75R"]},"labels":{"aa":"ORF1a: V2588F; ORF1b: M657I; ORF8: S67F; S: G75R","spike_mutations":"G75R"}}},{"name":"NODE_0000518","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}},"children":[{"name":"B.1.36.17","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.17"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.17"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.39","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2319C","C6573T","C9936A","C15981T","C25904T"],"ORF1a":["F685S","S2103F","T3224N"],"ORF3a":["S171L"]},"labels":{"aa":"ORF1a: F685S, S2103F, T3224N; ORF3a: S171L"}}}]}]}]}]}]}]}]},{"name":"NODE_0000519","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9009342193603516}},"branch_attrs":{"mutations":{"nuc":["G210T","T22917G","C23604G","T27638C","G28881T","G29402T","G29742T"],"N":["R203M","D377Y"],"ORF7a":["V82A"],"S":["T19R","L452R","P681R"]},"labels":{"aa":"N: R203M, D377Y; ORF7a: V82A; S: T19R, L452R, P681R","spike_mutations":"T19R, L452R, P681R"}},"children":[{"name":"B.1.617.3","node_attrs":{"div":22,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["C835T","C7296T","C8208T","G10634T","C11322T","C16293T","C21618G","G23012C","T27384C","C27970T","C28472T"],"N":["P67S"],"ORF1a":["A2344V","T2648I","A3457S","A3686V"],"ORF8":["T26I"],"S":["E484Q"]},"labels":{"aa":"N: P67S; ORF1a: A2344V, T2648I, A3457S, A3686V; ORF8: T26I; S: E484Q","spike_mutations":"E484Q"}}},{"name":"internal_d736","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.266930103302002}},"branch_attrs":{"mutations":{"nuc":["G21987A","C25469T"],"ORF3a":["S26L"],"S":["G142D"]},"labels":{"aa":"ORF3a: S26L; S: G142D","spike_mutations":"G142D"}},"children":[{"name":"B.1.617.1","node_attrs":{"div":25,"clade_display":{"value":"21B (Kappa)"},"Nextclade_pango":{"value":"B.1.617.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21B"},"clade_who":{"value":"Kappa"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"21B"},"placement_prior":{"value":-3.281346321105957}},"branch_attrs":{"mutations":{"nuc":["C3457T","C4965T","A11201G","G17523T","A20396G","T21895C","G22022A","G23012C","C26681T","T26767G"],"M":["I82S"],"ORF1a":["T1567I","T3646A"],"ORF1b":["M1352I","K2310R"],"S":["R19T","E154K","E484Q"]},"labels":{"aa":"M: I82S; ORF1a: T1567I, T3646A; ORF1b: M1352I, K2310R; S: R19T, E154K, E484Q","clade":"Kappa","spike_mutations":"R19T, E154K, E484Q"}}},{"name":"NODE_0000521","node_attrs":{"div":19,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.944439172744751}},"branch_attrs":{"mutations":{"nuc":["C21618G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22995A","G24410A","T26767C","C27752T","A28271-","A28461G"],"M":["I82T"],"N":["D63G"],"ORF7a":["T120I"],"ORF9b":["T60A"],"S":["E156-","F157-","R158G","T478K","D950N"]},"labels":{"aa":"M: I82T; N: D63G; ORF7a: T120I; ORF9b: T60A; S: E156-, F157-, R158G, T478K, D950N","clade":"Delta","spike_mutations":"E156-, F157-, R158G, T478K, D950N"}},"children":[{"name":"NODE_0000522","node_attrs":{"div":29,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.1252341270446777}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","C5184T","G9203A","T9678C","C11005A","A17496G","A20396G","A21792C","C28253T"],"ORF1a":["P309L","P1640L","D2980N","F3138S","H3580Q"],"ORF1b":["K2310R"],"S":["K77T"]},"labels":{"aa":"ORF1a: P309L, P1640L, D2980N, F3138S, H3580Q; ORF1b: K2310R; S: K77T","spike_mutations":"K77T"}},"children":[{"name":"AY.35","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.35"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.42242431640625}},"branch_attrs":{"mutations":{"nuc":["A1C","C6027A","C13989T","C16915T","G23012C"],"ORF1a":["P1921Q"],"S":["E484Q"]},"labels":{"aa":"ORF1a: P1921Q; S: E484Q","spike_mutations":"E484Q"}}},{"name":"AY.48","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.48"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A10399G","C10868T","G27948T"],"ORF8":["E19*"]},"labels":{"aa":"ORF8: E19*"}}}]},{"name":"NODE_0000523","node_attrs":{"div":21,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.307433843612671}},"branch_attrs":{"mutations":{"nuc":["G15451A","C16466T"],"ORF1b":["G662S","P1000L"]},"labels":{"aa":"ORF1b: G662S, P1000L"}},"children":[{"name":"B.1.617.2","node_attrs":{"div":21,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.307433843612671}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000524","node_attrs":{"div":24,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.925917625427246}},"branch_attrs":{"mutations":{"nuc":["C5184T","C9891T","T11418C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-"],"ORF1a":["P1640L","A3209V","V3718A"],"ORF8":["D119-","F120-"]},"labels":{"aa":"ORF1a: P1640L, A3209V, V3718A; ORF8: D119-, F120-"}},"children":[{"name":"NODE_0000525","node_attrs":{"div":29,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.995262622833252}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","T12946C","A20262G","C27739T"],"ORF1a":["P309L"],"ORF7a":["L116F"]},"labels":{"aa":"ORF1a: P309L; ORF7a: L116F"}},"children":[{"name":"NODE_0000526","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.093592643737793}},"branch_attrs":{"mutations":{"nuc":["C6539T","C20320T","C24745T","G28690T","G29427A"],"N":["L139F","R385K"],"ORF1a":["H2092Y"],"ORF1b":["H2285Y"]},"labels":{"aa":"N: L139F, R385K; ORF1a: H2092Y; ORF1b: H2285Y"}},"children":[{"name":"AY.30","node_attrs":{"div":37,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.30"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-02"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.6562891006469727}},"branch_attrs":{"mutations":{"nuc":["C9319T","A13482G","-28271A","G29781T"]}}},{"name":"AY.40","node_attrs":{"div":41,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.40"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["A1558G","C1912T","G2755T","A15892G","G23282T","C28099T","T28297C"],"ORF1a":["I431M"],"ORF1b":["M809V"],"ORF8":["S69L"],"ORF9b":["I5T"],"S":["D574Y"]},"labels":{"aa":"ORF1a: I431M; ORF1b: M809V; ORF8: S69L; ORF9b: I5T; S: D574Y","spike_mutations":"D574Y"}}}]},{"name":"NODE_0000527","node_attrs":{"div":30,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.395604133605957}},"branch_attrs":{"mutations":{"nuc":["C18176T"],"ORF1b":["P1570L"]},"labels":{"aa":"ORF1b: P1570L"}},"children":[{"name":"AY.49","node_attrs":{"div":36,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"21A"},"qc.frameShifts.frameShifts":{"value":"ORF3a:30-276"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF3a:30-276"},"partiallyAliased":{"value":"B.1.617.2.49"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T5773C","C10834T","C23039G","G24124T","G25471-","A25472-","T25473-","T25474-","T25475-","T25476-","G25477-","T25478-","C26110T","A27979T"],"ORF3a":["L26-","D27-","F28-","V29-"],"ORF8":["Q29L"],"S":["Q493E","K854N"]},"labels":{"aa":"ORF3a: L26-, D27-, F28-, V29-; ORF8: Q29L; S: Q493E, K854N","spike_mutations":"Q493E, K854N"}}},{"name":"AY.50","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.50"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C884T","C5730T","C19554T","G22484C","-28271A","G28809T"],"N":["G179V"],"ORF1a":["R207C","T1822I"],"S":["V308L"]},"labels":{"aa":"N: G179V; ORF1a: R207C, T1822I; S: V308L","spike_mutations":"V308L"}}},{"name":"AY.52","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.52"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["T24984G","T25689C","G26428T","C26858T","C28419T"],"E":["V62F"],"N":["T49I"],"S":["L1141W"]},"labels":{"aa":"E: V62F; N: T49I; S: L1141W","spike_mutations":"L1141W"}}},{"name":"AY.53","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.53"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.5879409313201904}},"branch_attrs":{"mutations":{"nuc":["G1738T","A2292C","C18348T","C20031T","G21641T"],"ORF1a":["Q676P"],"S":["A27S"]},"labels":{"aa":"ORF1a: Q676P; S: A27S","spike_mutations":"A27S"}}},{"name":"AY.8","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.8"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.8487331867218018}},"branch_attrs":{"mutations":{"nuc":["C11455T","A14170G"],"ORF1b":["I235V"]},"labels":{"aa":"ORF1b: I235V"}}},{"name":"NODE_0000528","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.849754571914673}},"branch_attrs":{"mutations":{"nuc":["A18468G"]}},"children":[{"name":"AY.13","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.13"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.3170342445373535}},"branch_attrs":{"mutations":{"nuc":["A17406G","C29095T"]}}},{"name":"NODE_0000529","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{"nuc":["T26076A"]}},"children":[{"name":"AY.16","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.16"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{}}},{"name":"AY.16.1","node_attrs":{"div":37,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.16.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C8407T","A12417G","G12911A","C14913T","T29867A"],"ORF1a":["N4051S","V4216I"]},"labels":{"aa":"ORF1a: N4051S, V4216I"}}}]}]},{"name":"NODE_0000530","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.429879188537598}},"branch_attrs":{"mutations":{"nuc":["C19160T"],"ORF1b":["S1898F"]},"labels":{"aa":"ORF1b: S1898F"}},"children":[{"name":"AY.15","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.15"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.385550022125244}},"branch_attrs":{"mutations":{"nuc":["A16872G","G27382C","-28271A"],"ORF6":["D61H"]},"labels":{"aa":"ORF6: D61H"}}},{"name":"AY.14","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.14"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1877G","G20718T"],"ORF1a":["S538A"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1a: S538A; ORF1b: M2417I"}}},{"name":"AY.54","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.54"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.0774948596954346}},"branch_attrs":{"mutations":{"nuc":["A1G","C193T","G14187A","A25806G"]}}}]},{"name":"NODE_0000531","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.021132946014404}},"branch_attrs":{"mutations":{"nuc":["A25562G"],"ORF3a":["Q57R"]},"labels":{"aa":"ORF3a: Q57R"}},"children":[{"name":"AY.17","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.17"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2240G","C14708T","C17436T","-28271A"],"ORF1a":["I659V"],"ORF1b":["A414V"]},"labels":{"aa":"ORF1a: I659V; ORF1b: A414V"}}},{"name":"AY.19","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.19"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25019T","G25947T","-28271A"],"ORF3a":["Q185H"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: Q185H; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"AY.51","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.51"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.13735818862915}},"branch_attrs":{"mutations":{"nuc":["G12223T","A25697T"],"ORF3a":["E102V"]},"labels":{"aa":"ORF3a: E102V"}}}]}]}]},{"name":"NODE_0000532","node_attrs":{"div":26,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.616595983505249}},"branch_attrs":{"mutations":{"nuc":["C11514T","C22227T"],"ORF1a":["T3750I"],"S":["A222V"]},"labels":{"aa":"ORF1a: T3750I; S: A222V","clade":"21I","spike_mutations":"A222V"}},"children":[{"name":"AY.62","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.62"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["A1045T","G1820A","A20085G","C28093T","G29440A"],"ORF1a":["G519S"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: G519S; ORF8: S67F"}}},{"name":"NODE_0000533","node_attrs":{"div":27,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.667755365371704}},"branch_attrs":{"mutations":{"nuc":["A5584G"]}},"children":[{"name":"AY.24","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.24"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-17"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.5928659439086914}},"branch_attrs":{"mutations":{"nuc":["C23896T","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"NODE_0000534","node_attrs":{"div":28,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.900347948074341}},"branch_attrs":{"mutations":{"nuc":["C13019T"]}},"children":[{"name":"AY.10","node_attrs":{"div":34,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.10"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.07296895980835}},"branch_attrs":{"mutations":{"nuc":["G219T","A8651G","G9526T","C12756T","C13665T","A23734G"],"ORF1a":["M2796V","M3087I","T4164I"]},"labels":{"aa":"ORF1a: M2796V, M3087I, T4164I"}}},{"name":"AY.11","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.11"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-09"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.418825149536133}},"branch_attrs":{"mutations":{"nuc":["C3486T","C18526T","T19516C","G26526T","C29509T"],"M":["A2S"],"ORF1a":["A1074V"],"ORF1b":["R1687C"]},"labels":{"aa":"M: A2S; ORF1a: A1074V; ORF1b: R1687C"}}},{"name":"AY.27","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.27"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.842771530151367}},"branch_attrs":{"mutations":{"nuc":["T11938C","A14475G","G29422T"]}}},{"name":"AY.28","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.28"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C335T","G2167T","C8950T","C9246T","G23663T","G24794T","G25855T"],"ORF1a":["R24C","K634N","A2994V"],"ORF3a":["D155Y"],"S":["A701S","A1078S"]},"labels":{"aa":"ORF1a: R24C, K634N, A2994V; ORF3a: D155Y; S: A701S, A1078S","spike_mutations":"A701S, A1078S"}}},{"name":"AY.47","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.47"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.620307207107544}},"branch_attrs":{"mutations":{"nuc":["C1684T","G5164T","C12049T","G22427A","G28326T"],"N":["G18V"],"ORF1a":["E1633D"],"ORF9b":["V15L"],"S":["V289I"]},"labels":{"aa":"N: G18V; ORF1a: E1633D; ORF9b: V15L; S: V289I","spike_mutations":"V289I"}}},{"name":"AY.55","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.55"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.71439266204834}},"branch_attrs":{"mutations":{"nuc":["A10978G","-28271A"]}}},{"name":"AY.56","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.56"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3634T","C25624T","G27870T"],"ORF3a":["H78Y"],"ORF7b":["E39*"]},"labels":{"aa":"ORF3a: H78Y; ORF7b: E39*"}}},{"name":"AY.57","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.57"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.764986515045166}},"branch_attrs":{"mutations":{"nuc":["C1403T","G5584T"],"ORF1a":["P380S"]},"labels":{"aa":"ORF1a: P380S"}}},{"name":"AY.59","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.59"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C19164T","T20391G","C21302T"],"ORF1b":["P2612L"]},"labels":{"aa":"ORF1b: P2612L"}}},{"name":"AY.60","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.60"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A2165C","C2919T","G4162T","T8634C","T12056A","T13701C","G17122T"],"ORF1a":["K634Q","P885L","I2790T","C3931S"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1a: K634Q, P885L, I2790T, C3931S; ORF1b: A1219S"}}},{"name":"AY.61","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.61"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9422552585601807}},"branch_attrs":{"mutations":{"nuc":["T25532C"],"ORF3a":["I47T"]},"labels":{"aa":"ORF3a: I47T"}}},{"name":"AY.64","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.64"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9437766075134277}},"branch_attrs":{"mutations":{"nuc":["T2C","C346T","C5784T","C6388T","C24130T","G25135T","G25691T","C27005T","G29254T","G29688T"],"ORF1a":["T1840I"],"ORF3a":["G100V"],"S":["K1191N"]},"labels":{"aa":"ORF1a: T1840I; ORF3a: G100V; S: K1191N","spike_mutations":"K1191N"}}},{"name":"AY.67","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.67"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C4890T","T5644C","T19519C","A27368G"],"ORF1a":["T1542I"],"ORF1b":["Y2018H"],"ORF6":["Q56R"]},"labels":{"aa":"ORF1a: T1542I; ORF1b: Y2018H; ORF6: Q56R"}}},{"name":"AY.68","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.68"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.760132312774658}},"branch_attrs":{"mutations":{"nuc":["G105T","C3294T","C8208T","C14362T","C19524T","A22320C","T24499A","C25782T","A26891G","T27878C"],"ORF1a":["P1010L","T2648I"],"S":["D253A","D979E"]},"labels":{"aa":"ORF1a: P1010L, T2648I; S: D253A, D979E","spike_mutations":"D253A, D979E"}}},{"name":"AY.66","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.66"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T13C","T6496C","G14874T","C28892T"],"N":["P207S"],"ORF1b":["K469N"]},"labels":{"aa":"N: P207S; ORF1b: K469N"}}},{"name":"AY.69","node_attrs":{"div":36,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.69"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C3984T","A4405T","A4838G","G9431A","G16864A","G17847A","G25720T","C27559T"],"ORF1a":["T1240I","I1525V","V3056I"],"ORF1b":["V1133I"],"ORF3a":["A110S"]},"labels":{"aa":"ORF1a: T1240I, I1525V, V3056I; ORF1b: V1133I; ORF3a: A110S"}}},{"name":"AY.70","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.70"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.4444899559020996}},"branch_attrs":{"mutations":{"nuc":["C4891T","G21255T","G21624C","G28899T","G28903T"],"N":["R209I","M210I"],"S":["R21T"]},"labels":{"aa":"N: R209I, M210I; S: R21T","spike_mutations":"R21T"}}},{"name":"NODE_0000535","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.80359411239624}},"branch_attrs":{"mutations":{"nuc":["C5192T"]}},"children":[{"name":"AY.58","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.58"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["G8540A","C26079A","C27131T"],"ORF1a":["A2759T"]},"labels":{"aa":"ORF1a: A2759T"}}},{"name":"AY.63","node_attrs":{"div":39,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.63"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.740610122680664}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","A7886G","C8964T","C9857T","C13335T","A14246G","A19126G","A23848G","C25710T","G29616T","T29728C"],"ORF1a":["K141-","S142-","F143-","I2541V","S2900L","A4357V"],"ORF1b":["D260G","I1887V"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I2541V, S2900L, A4357V; ORF1b: D260G, I1887V"}}}]},{"name":"NODE_0000536","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1813859939575195}},"branch_attrs":{"mutations":{"nuc":["C21622T"]}},"children":[{"name":"AY.75","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1813859939575195}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000537","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.644587278366089}},"branch_attrs":{"mutations":{"nuc":["G29744A"]}},"children":[{"name":"AY.75.2","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-19"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T13C","T7717C","A16824G","A21987G","G23611T"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}}},{"name":"AY.75.3","node_attrs":{"div":36,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-19"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T322C","C1329A","G8428A","G16873A","T19127C","C22314T"],"ORF1a":["T355N"],"ORF1b":["G1136S","I1887T"],"S":["P251L"]},"labels":{"aa":"ORF1a: T355N; ORF1b: G1136S, I1887T; S: P251L","spike_mutations":"P251L"}}}]}]},{"name":"NODE_0000538","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.335732936859131}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"AY.9","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.335732936859131}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000539","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.805464744567871}},"branch_attrs":{"mutations":{"nuc":["G1729A","G14030A","C18086T"],"ORF1b":["R188Q","T1540I"]},"labels":{"aa":"ORF1b: R188Q, T1540I"}},"children":[{"name":"AY.9.2","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.805464744567871}},"branch_attrs":{"mutations":{}}},{"name":"AY.9.2.2","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6840121746063232}},"branch_attrs":{"mutations":{"nuc":["C4321T","A9685G","C23585A"],"ORF1a":["I3140M"],"S":["Q675K"]},"labels":{"aa":"ORF1a: I3140M; S: Q675K","spike_mutations":"Q675K"}}}]}]},{"name":"NODE_0000540","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.977773427963257}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.133","node_attrs":{"div":40,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.133"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.133"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-01"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C203T","C449T","C4763T","C12025T","C20104T","T21613A","C21614T","C23058G","C24370T","T25333C","T29867A"],"ORF1a":["P62S","H1500Y"],"ORF1b":["L2213F"],"S":["N17K","L18F","P499R"]},"labels":{"aa":"ORF1a: P62S, H1500Y; ORF1b: L2213F; S: N17K, L18F, P499R","spike_mutations":"N17K, L18F, P499R"}}},{"name":"NODE_0000541","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T13019C"]}},"children":[{"name":"AY.65","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:121-122"},"partiallyAliased":{"value":"B.1.617.2.65"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G14028T","C27005T","-28253T","-28271A"],"ORF1b":["M187I"]},"labels":{"aa":"ORF1b: M187I"}}},{"name":"NODE_0000542","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.0165014266967773}},"branch_attrs":{"mutations":{"nuc":["A27345T"],"ORF6":["K48N"]},"labels":{"aa":"ORF6: K48N"}},"children":[{"name":"AY.26","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.26"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.0165014266967773}},"branch_attrs":{"mutations":{}}},{"name":"AY.26.1","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.26.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G20580T","A21987G","G23012C","A24587T","G26529C","G27703T","C29769T"],"M":["D3H"],"ORF7a":["V104F"],"S":["D142G","E484Q","T1009S"]},"labels":{"aa":"M: D3H; ORF7a: V104F; S: D142G, E484Q, T1009S","spike_mutations":"D142G, E484Q, T1009S"}}}]}]}]},{"name":"NODE_0000543","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.119155406951904}},"branch_attrs":{"mutations":{"nuc":["C2509T"]}},"children":[{"name":"AY.2","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-14"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6743454933166504}},"branch_attrs":{"mutations":{"nuc":["A1G","T3055C","G3701A","C17336T","C18570T","G21770T","G22813T","T29867A","G29868A"],"ORF1a":["A1146T"],"ORF1b":["T1290I"],"S":["V70F","K417N"]},"labels":{"aa":"ORF1a: A1146T; ORF1b: T1290I; S: V70F, K417N","spike_mutations":"V70F, K417N"}}},{"name":"AY.38","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.38"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.963697910308838}},"branch_attrs":{"mutations":{"nuc":["G15760T","A22310T","-28271A","G29212T","T29742G"],"ORF1b":["G765C"],"S":["T250S"]},"labels":{"aa":"ORF1b: G765C; S: T250S","spike_mutations":"T250S"}}},{"name":"AY.37","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.37"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6478559970855713}},"branch_attrs":{"mutations":{"nuc":["G2185T","T20911C"],"ORF1a":["E640D"]},"labels":{"aa":"ORF1a: E640D"}}},{"name":"AY.71","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.71"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.8321352005004883}},"branch_attrs":{"mutations":{"nuc":["A1T","C25317T","-28271A"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"NODE_0000544","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.954825401306152}},"branch_attrs":{"mutations":{"nuc":["G5539A"]}},"children":[{"name":"AY.72","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.72"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.11883020401001}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G6080T","A25856G","C26013T"],"ORF1a":["K141-","S142-","F143-","D1939Y"],"ORF3a":["D155G"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, D1939Y; ORF3a: D155G"}}},{"name":"AY.74","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.74"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1409428119659424}},"branch_attrs":{"mutations":{"nuc":["G3994A","C25413T","G29392T"],"N":["K373N"]},"labels":{"aa":"N: K373N"}}},{"name":"AY.73","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.73"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9488861560821533}},"branch_attrs":{"mutations":{"nuc":["C222T","C6573T","C27657T","C28409T","C28893T"],"N":["P46S","P207L"],"ORF1a":["S2103F"]},"labels":{"aa":"N: P46S, P207L; ORF1a: S2103F"}}}]}]}]}]}]}]},{"name":"NODE_0000545","node_attrs":{"div":31,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1954586505889893}},"branch_attrs":{"mutations":{"nuc":["G4181T","C6402T","C7124T","C8986T","C10029T","A11201G","A11332G","C19220T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","G28916T"],"N":["G215C"],"ORF1a":["A1306S","P2046L","P2287S","T3255I","T3646A"],"ORF1b":["A1918V"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"]},"labels":{"aa":"N: G215C; ORF1a: A1306S, P2046L, P2287S, T3255I, T3646A; ORF1b: A1918V; ORF7b: T40I; ORF8: D119-, F120-","clade":"21J"}},"children":[{"name":"AY.78","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.78"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.552375793457031}},"branch_attrs":{"mutations":{"nuc":["T13188C","G14874T","G15372T","C21846T","-28271A","C29200T","G29227A"],"ORF1a":["I4308T"],"ORF1b":["K469N"],"S":["T95I"]},"labels":{"aa":"ORF1a: I4308T; ORF1b: K469N; S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000546","node_attrs":{"div":32,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.353039264678955}},"branch_attrs":{"mutations":{"nuc":["G9053T"],"ORF1a":["V2930L"]},"labels":{"aa":"ORF1a: V2930L"}},"children":[{"name":"AY.109","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.109"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.109"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6555240154266357}},"branch_attrs":{"mutations":{"nuc":["A11595G","A14836G","C27549T"],"ORF1a":["Q3777R"],"ORF1b":["I457V"]},"labels":{"aa":"ORF1a: Q3777R; ORF1b: I457V"}}},{"name":"AY.44","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.44"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.8053845167160034}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14014G","A29700G"],"ORF1b":["F183V"]},"labels":{"aa":"ORF1b: F183V"}}},{"name":"AY.6","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.7393529415130615}},"branch_attrs":{"mutations":{"nuc":["G2336A","G17331T"],"ORF1a":["D691N"],"ORF1b":["E1288D"]},"labels":{"aa":"ORF1a: D691N; ORF1b: E1288D"}}},{"name":"AY.76","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.76"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.615240097045898}},"branch_attrs":{"mutations":{"nuc":["T7233C","A16775G"],"ORF1a":["L2323S"],"ORF1b":["Y1103C"]},"labels":{"aa":"ORF1a: L2323S; ORF1b: Y1103C"}}},{"name":"AY.77","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:120-122"},"partiallyAliased":{"value":"B.1.617.2.77"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.287630558013916}},"branch_attrs":{"mutations":{"nuc":["C10376T","T27346C","-28250T","-28251T","-28252T","-28253C"],"ORF1a":["P3371S"],"ORF6":["Y49H"]},"labels":{"aa":"ORF1a: P3371S; ORF6: Y49H"}}},{"name":"AY.79","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.79"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7262611389160156}},"branch_attrs":{"mutations":{"nuc":["T2125C"]}}},{"name":"AY.80","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.80"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.398505210876465}},"branch_attrs":{"mutations":{"nuc":["G5017A","G12479A","C19186T","G19735T","G28028T"],"ORF1a":["V4072I"],"ORF1b":["D2090Y"],"ORF8":["W45C"]},"labels":{"aa":"ORF1a: V4072I; ORF1b: D2090Y; ORF8: W45C"}}},{"name":"AY.81","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.81"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.495386123657227}},"branch_attrs":{"mutations":{"nuc":["G11358A","C23643T","G25340T","A28032G","C28087T","C29530T"],"ORF1a":["R3698K"],"ORF8":["I47V","A65V"],"S":["A694V","D1260Y"]},"labels":{"aa":"ORF1a: R3698K; ORF8: I47V, A65V; S: A694V, D1260Y","spike_mutations":"A694V, D1260Y"}}},{"name":"AY.82","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.82"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.4367475509643555}},"branch_attrs":{"mutations":{"nuc":["C9144T","C22783T"],"ORF1a":["S2960F"]},"labels":{"aa":"ORF1a: S2960F"}}},{"name":"AY.83","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.83"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.207631587982178}},"branch_attrs":{"mutations":{"nuc":["C5544T","G15243T","A25491T"],"ORF1a":["T1760I"],"ORF1b":["M592I"]},"labels":{"aa":"ORF1a: T1760I; ORF1b: M592I"}}},{"name":"AY.84","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.84"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.84"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.880310297012329}},"branch_attrs":{"mutations":{"nuc":["C27297T","G28086T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"AY.86","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.86"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.149416446685791}},"branch_attrs":{"mutations":{"nuc":["G15380T","G24095T","C29445T"],"N":["T391I"],"ORF1b":["S638I"],"S":["A845S"]},"labels":{"aa":"N: T391I; ORF1b: S638I; S: A845S","spike_mutations":"A845S"}}},{"name":"AY.87","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.87"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.119330883026123}},"branch_attrs":{"mutations":{"nuc":["C832T","C2091T","C12651T","C17156T","A19815T","G27556T"],"ORF1a":["T609I","T4129I"],"ORF1b":["T1230I"],"ORF7a":["A55S"]},"labels":{"aa":"ORF1a: T609I, T4129I; ORF1b: T1230I; ORF7a: A55S"}}},{"name":"AY.88","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.88"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.88"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.2233734130859375}},"branch_attrs":{"mutations":{"nuc":["G20709T","C28724T"],"N":["P151S"],"ORF1b":["M2414I"]},"labels":{"aa":"N: P151S; ORF1b: M2414I"}}},{"name":"AY.93","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.93"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.93"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.618436336517334}},"branch_attrs":{"mutations":{"nuc":["A1087G","C1101T","C7262T"],"ORF1a":["S279F","L2333F"]},"labels":{"aa":"ORF1a: S279F, L2333F"}}},{"name":"AY.94","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.94"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.94"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7355687618255615}},"branch_attrs":{"mutations":{"nuc":["G463A","G6367T","C15924T","G16975T","C22987T"],"ORF1a":["Q2034H"],"ORF1b":["V1170F"]},"labels":{"aa":"ORF1a: Q2034H; ORF1b: V1170F"}}},{"name":"NODE_0000547","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.328933000564575}},"branch_attrs":{"mutations":{"nuc":["A17236G"],"ORF1b":["I1257V"]},"labels":{"aa":"ORF1b: I1257V"}},"children":[{"name":"AY.103","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.103"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.103"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7267297506332397}},"branch_attrs":{"mutations":{"nuc":["C24208T"]}}},{"name":"AY.41","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.41"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3743410110473633}},"branch_attrs":{"mutations":{"nuc":["G1820A","G2272T","G7936T","G9220A","A13712G","C14119T","C18395T","G22346T","G22992T","G25062T","-28271A"],"ORF1a":["G519S","K669N"],"ORF1b":["K82R","P218S","A1643V"],"S":["A262S","S477I","G1167V"]},"labels":{"aa":"ORF1a: G519S, K669N; ORF1b: K82R, P218S, A1643V; S: A262S, S477I, G1167V","spike_mutations":"A262S, S477I, G1167V"}}}]},{"name":"NODE_0000548","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.456480503082275}},"branch_attrs":{"mutations":{"nuc":["C897T","C5730T","A7519C","C15738T","G17790T","C25350T","G27762T"],"ORF1a":["A211V","T1822I"],"ORF1b":["Q1441H"],"ORF7b":["E3*"],"S":["P1263L"]},"labels":{"aa":"ORF1a: A211V, T1822I; ORF1b: Q1441H; ORF7b: E3*; S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"AY.123","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.123"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-23"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.456480503082275}},"branch_attrs":{"mutations":{}}},{"name":"AY.123.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.123.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.658047676086426}},"branch_attrs":{"mutations":{"nuc":["G20002T","A24410G"],"ORF1b":["D2179Y"],"S":["N950D"]},"labels":{"aa":"ORF1b: D2179Y; S: N950D","spike_mutations":"N950D"}}}]},{"name":"NODE_0000549","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.341156005859375}},"branch_attrs":{"mutations":{"nuc":["C1404T","C4752T","G25352T"],"ORF1a":["P380L","T1496I"],"S":["V1264L"]},"labels":{"aa":"ORF1a: P380L, T1496I; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.23","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.23"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.341156005859375}},"branch_attrs":{"mutations":{}}},{"name":"AY.23.1","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.23.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4683516025543213}},"branch_attrs":{"mutations":{"nuc":["C1263T","C5497T","A7537G","C12100T","A14748G","G17679T","T22213C","C25262A"],"ORF1a":["T333M"],"S":["L1234I"]},"labels":{"aa":"ORF1a: T333M; S: L1234I","spike_mutations":"L1234I"}}}]},{"name":"NODE_0000550","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.604698181152344}},"branch_attrs":{"mutations":{"nuc":["C23277T","G24124A","-28271A"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"AY.32","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.32"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-03"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.967384099960327}},"branch_attrs":{"mutations":{"nuc":["C9286T","C21304T"],"ORF1b":["R2613C"]},"labels":{"aa":"ORF1b: R2613C"}}},{"name":"AY.95","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.95"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.95"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.071098804473877}},"branch_attrs":{"mutations":{"nuc":["T22293C"],"S":["L244S"]},"labels":{"aa":"S: L244S","spike_mutations":"L244S"}}}]},{"name":"NODE_0000551","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.153012275695801}},"branch_attrs":{"mutations":{"nuc":["A21647G","C22311T"],"S":["T29A","T250I"]},"labels":{"aa":"S: T29A, T250I","spike_mutations":"T29A, T250I"}},"children":[{"name":"AY.33.1","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:77-122"},"partiallyAliased":{"value":"B.1.617.2.33.1"},"totalAminoacidDeletions":{"value":26},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C4182T","T10190C","A11111G","C14318T","C17439T","A18887G","G21010T","C21707T","C22458T","G23401T","G23522A","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-"],"ORF1a":["S1306F","S3309P","M3616V"],"ORF1b":["T284I","H1807R","V2515L"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-"],"S":["H49Y","T299I","Q613H","E654K"]},"labels":{"aa":"ORF1a: S1306F, S3309P, M3616V; ORF1b: T284I, H1807R, V2515L; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-; S: H49Y, T299I, Q613H, E654K","spike_mutations":"H49Y, T299I, Q613H, E654K"}}},{"name":"AY.33","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.33"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.153012275695801}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000552","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.514620304107666}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"AY.46.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.053738117218018}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T","G14186T","C19637T","A21987G","G28378T"],"ORF1a":["A3571V"],"ORF1b":["R240M","A2057V"],"ORF9b":["R32L"],"S":["D142G"]},"labels":{"aa":"ORF1a: A3571V; ORF1b: R240M, A2057V; ORF9b: R32L; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.90","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.90"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.90"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9251A","C25931T","G26720A","G27990T","T28735C"],"ORF1a":["V2996I"],"ORF3a":["S180F"],"ORF8":["V33F"]},"labels":{"aa":"ORF1a: V2996I; ORF3a: S180F; ORF8: V33F"}}}]},{"name":"NODE_0000553","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.887284278869629}},"branch_attrs":{"mutations":{"nuc":["G526T","C19524T"],"ORF1a":["E87D"]},"labels":{"aa":"ORF1a: E87D"}},"children":[{"name":"AY.98","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.98"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.887284278869629}},"branch_attrs":{"mutations":{}}},{"name":"AY.98.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.98.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.6238064765930176}},"branch_attrs":{"mutations":{"nuc":["G2518T","G5437T","C7768T","C22314T","G28086T"],"ORF1a":["E1724D"],"ORF8":["A65S"],"S":["P251L"]},"labels":{"aa":"ORF1a: E1724D; ORF8: A65S; S: P251L","spike_mutations":"P251L"}}}]},{"name":"NODE_0000554","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.317579746246338}},"branch_attrs":{"mutations":{"nuc":["A1G","G26107C","A27507C"],"ORF3a":["E239Q"]},"labels":{"aa":"ORF3a: E239Q"}},"children":[{"name":"AY.25","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.317579746246338}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000555","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432563543319702}},"branch_attrs":{"mutations":{"nuc":["A3948G","G11562T"],"ORF1a":["D1228G","C3766F"]},"labels":{"aa":"ORF1a: D1228G, C3766F"}},"children":[{"name":"AY.25.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432563543319702}},"branch_attrs":{"mutations":{}}},{"name":"AY.25.1.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2407732009887695}},"branch_attrs":{"mutations":{"nuc":["G2564A","A21987G","G23948T"],"ORF1a":["E767K"],"S":["D142G","D796Y"]},"labels":{"aa":"ORF1a: E767K; S: D142G, D796Y","spike_mutations":"D142G, D796Y"}}}]}]},{"name":"NODE_0000556","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.293525695800781}},"branch_attrs":{"mutations":{"nuc":["C25413T","-28271A"]}},"children":[{"name":"AY.45","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.45"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.303795337677002}},"branch_attrs":{"mutations":{"nuc":["G13812T"],"ORF1b":["M115I"]},"labels":{"aa":"ORF1b: M115I"}}},{"name":"NODE_0000557","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.198975563049316}},"branch_attrs":{"mutations":{"nuc":["T1871C","C28236T","G29744A"],"ORF1a":["F536L"],"ORF8":["R115C"]},"labels":{"aa":"ORF1a: F536L; ORF8: R115C"}},"children":[{"name":"AY.91.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.91.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.92111349105835}},"branch_attrs":{"mutations":{"nuc":["C15540T","C17010T","G25650T","A28271-","C28310T"],"N":["P13S"],"ORF3a":["L86F"]},"labels":{"aa":"N: P13S; ORF3a: L86F"}}},{"name":"AY.91","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.91"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.198975563049316}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000558","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.897754669189453}},"branch_attrs":{"mutations":{"nuc":["T2C","G2944A","G11365T","G12718T","G27566T","C27629A"],"ORF1a":["Q4151H"],"ORF7a":["C58F","A79D"]},"labels":{"aa":"ORF1a: Q4151H; ORF7a: C58F, A79D"}},"children":[{"name":"AY.7","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.897754669189453}},"branch_attrs":{"mutations":{}}},{"name":"AY.7.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-13"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1598992347717285}},"branch_attrs":{"mutations":{"nuc":["T15882G","A18675G"]}}},{"name":"AY.7.2","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-13"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.763446092605591}},"branch_attrs":{"mutations":{"nuc":["C2T","G25445T"],"ORF3a":["G18V"]},"labels":{"aa":"ORF3a: G18V"}}}]},{"name":"NODE_0000559","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5587968826293945}},"branch_attrs":{"mutations":{"nuc":["A3536G","T13216C","C15240T"],"ORF1a":["I1091V"]},"labels":{"aa":"ORF1a: I1091V"}},"children":[{"name":"AY.99","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5587968826293945}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000560","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.528911113739014}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.99.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.143618583679199}},"branch_attrs":{"mutations":{"nuc":["C8994T"],"ORF1a":["T2910I"]},"labels":{"aa":"ORF1a: T2910I"}}},{"name":"AY.99.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.7914319038391113}},"branch_attrs":{"mutations":{"nuc":["C4927T","A5638G","C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}}]}]},{"name":"NODE_0000561","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.159926652908325}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"AY.122","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.159926652908325}},"branch_attrs":{"mutations":{}}},{"name":"AY.122.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5672764778137207}},"branch_attrs":{"mutations":{"nuc":["C19983T","G20937T","C23934T","C25516T"],"ORF3a":["P42S"],"S":["T791I"]},"labels":{"aa":"ORF3a: P42S; S: T791I","spike_mutations":"T791I"}}},{"name":"AY.122.3","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.337822437286377}},"branch_attrs":{"mutations":{"nuc":["T168C","C12513T","G17338A","T17694C","T20838C","G23401T","C27527T","C28873A"],"ORF1a":["T4083M"],"ORF1b":["A1291T"],"ORF7a":["P45L"],"S":["Q613H"]},"labels":{"aa":"ORF1a: T4083M; ORF1b: A1291T; ORF7a: P45L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"AY.122.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7381060123443604}},"branch_attrs":{"mutations":{"nuc":["G13892A","G14772A","G22793T"],"ORF1b":["C142Y"],"S":["A411S"]},"labels":{"aa":"ORF1b: C142Y; S: A411S","spike_mutations":"A411S"}}}]},{"name":"NODE_0000562","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.67804217338562}},"branch_attrs":{"mutations":{"nuc":["T3C","A11456G","G29050A","C29509T"],"ORF1a":["I3731V"]},"labels":{"aa":"ORF1a: I3731V"}},"children":[{"name":"AY.3","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-30"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.67804217338562}},"branch_attrs":{"mutations":{}}},{"name":"AY.3.2","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.84430193901062}},"branch_attrs":{"mutations":{"nuc":["G5155A","C5784T","A10075G","A21987G","C22338T","C29546T","C29750T"],"ORF1a":["T1840I"],"S":["D142G","T259I"]},"labels":{"aa":"ORF1a: T1840I; S: D142G, T259I","spike_mutations":"D142G, T259I"}}},{"name":"NODE_0000563","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.2109897136688232}},"branch_attrs":{"mutations":{"nuc":["T23284C","C25339T"]}},"children":[{"name":"AY.3.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-23"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9937832355499268}},"branch_attrs":{"mutations":{"nuc":["G3644T","C18115T","C20199T","A21987G"],"ORF1a":["D1127Y"],"ORF1b":["H1550Y"],"S":["D142G"]},"labels":{"aa":"ORF1a: D1127Y; ORF1b: H1550Y; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.3.3","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.715099811553955}},"branch_attrs":{"mutations":{"nuc":["T2083C","A6229G","C9924T","T12538C","G21770A","A22803G","A26021C"],"ORF1a":["A3220V"],"ORF3a":["D210A"],"S":["V70I","Q414R"]},"labels":{"aa":"ORF1a: A3220V; ORF3a: D210A; S: V70I, Q414R","spike_mutations":"V70I, Q414R"}}}]}]},{"name":"NODE_0000564","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3763246536254883}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T"],"ORF1a":["A3571V"]},"labels":{"aa":"ORF1a: A3571V"}},"children":[{"name":"AY.46.2","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9185075759887695}},"branch_attrs":{"mutations":{"nuc":["A17799G","-28271A"]}}},{"name":"AY.46","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3763246536254883}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.46.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.001236915588379}},"branch_attrs":{"mutations":{"nuc":["T25673C"],"ORF3a":["L94P"]},"labels":{"aa":"ORF3a: L94P"}}},{"name":"AY.46.6","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.815885066986084}},"branch_attrs":{"mutations":{"nuc":["C6310T","C8326T"]}}},{"name":"AY.46.5","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0684127807617188}},"branch_attrs":{"mutations":{"nuc":["C15569T","T16242G"],"ORF1b":["T701I"]},"labels":{"aa":"ORF1b: T701I"}}},{"name":"AY.46.4","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.352943181991577}},"branch_attrs":{"mutations":{"nuc":["G23545T"],"S":["E661D"]},"labels":{"aa":"S: E661D","spike_mutations":"E661D"}}}]},{"name":"NODE_0000565","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6843671798706055}},"branch_attrs":{"mutations":{"nuc":["G24928T"]}},"children":[{"name":"AY.5","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6843671798706055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000566","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432929515838623}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}},"children":[{"name":"AY.5.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.634615898132324}},"branch_attrs":{"mutations":{"nuc":["C27143A"],"M":["N207K"]},"labels":{"aa":"M: N207K"}}},{"name":"AY.5.3","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.852130651473999}},"branch_attrs":{"mutations":{"nuc":["C7488T"],"ORF1a":["T2408I"]},"labels":{"aa":"ORF1a: T2408I"}}},{"name":"AY.5.4","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5176773071289062}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"AY.5.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.416350364685059}},"branch_attrs":{"mutations":{"nuc":["C12369T","C25572T"],"ORF1a":["T4035I"]},"labels":{"aa":"ORF1a: T4035I"}}},{"name":"AY.5.5","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C6840T","G17193T","T23398C"],"ORF1a":["A2192V"],"ORF1b":["E1242D"]},"labels":{"aa":"ORF1a: A2192V; ORF1b: E1242D"}}}]}]},{"name":"NODE_0000567","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.3014614582061768}},"branch_attrs":{"mutations":{"nuc":["C15952A","A28299T"],"N":["Q9L"],"ORF1b":["L829I"],"ORF9b":["S6C"]},"labels":{"aa":"N: Q9L; ORF1b: L829I; ORF9b: S6C"}},"children":[{"name":"AY.43","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.3014614582061768}},"branch_attrs":{"mutations":{}}},{"name":"AY.43.5","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["A17457G","A23064G","C23638T","C24937T","C28045T","G28857T","G29179T"],"N":["R195I"],"ORF8":["A51V"],"S":["N501S"]},"labels":{"aa":"N: R195I; ORF8: A51V; S: N501S","spike_mutations":"N501S"}}},{"name":"NODE_0000568","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.2774245738983154}},"branch_attrs":{"mutations":{"nuc":["C18744T","C24130T"]}},"children":[{"name":"AY.43.3","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.8283350467681885}},"branch_attrs":{"mutations":{"nuc":["C19955T"],"ORF1b":["T2163I"]},"labels":{"aa":"ORF1b: T2163I"}}},{"name":"AY.43.4","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.776319980621338}},"branch_attrs":{"mutations":{"nuc":["C5241T"],"ORF1a":["P1659L"]},"labels":{"aa":"ORF1a: P1659L"}}},{"name":"AY.43.6","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3442535400390625}},"branch_attrs":{"mutations":{"nuc":["C233T","C1952A","T27409C","G29081T"],"N":["V270L"],"ORF1a":["Q563K"],"ORF7a":["F6L"]},"labels":{"aa":"N: V270L; ORF1a: Q563K; ORF7a: F6L"}}},{"name":"NODE_0000569","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.388669013977051}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.43.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.167776584625244}},"branch_attrs":{"mutations":{"nuc":["C12663T","C25433T"],"ORF1a":["A4133V"],"ORF3a":["T14I"]},"labels":{"aa":"ORF1a: A4133V; ORF3a: T14I"}}},{"name":"AY.43.2","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.031640529632568}},"branch_attrs":{"mutations":{"nuc":["G3728T"],"ORF1a":["G1155C"]},"labels":{"aa":"ORF1a: G1155C"}}},{"name":"AY.43.7","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-26"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.195249557495117}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}}}]}]}]},{"name":"NODE_0000570","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.174302339553833}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}},"children":[{"name":"AY.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-04"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.566736936569214}},"branch_attrs":{"mutations":{"nuc":["G22335T","G22813T"],"S":["W258L","K417N"]},"labels":{"aa":"S: W258L, K417N","spike_mutations":"W258L, K417N"}}},{"name":"AY.105","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.105"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.105"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.090245246887207}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2939T"],"ORF1a":["P892S"]},"labels":{"aa":"ORF1a: P892S"}}},{"name":"AY.107","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.107"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.107"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.489321231842041}},"branch_attrs":{"mutations":{"nuc":["A15012G","C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"AY.106","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.106"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.106"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.667900800704956}},"branch_attrs":{"mutations":{"nuc":["C9811T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"AY.112","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.112"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.112"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2532191276550293}},"branch_attrs":{"mutations":{"nuc":["G25647T","-28271A"],"ORF3a":["L85F"]},"labels":{"aa":"ORF3a: L85F"}}},{"name":"AY.111","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.111"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.111"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2215194702148438}},"branch_attrs":{"mutations":{"nuc":["C4456T"]}}},{"name":"AY.110","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.110"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.110"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5870707035064697}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","C912A"],"ORF1a":["K141-","S142-","F143-","S216Y"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, S216Y"}}},{"name":"AY.117","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.117"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.117"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.009160041809082}},"branch_attrs":{"mutations":{"nuc":["A1G","G2202T","G14186T","C15810T","C28708T"],"ORF1a":["W646L"],"ORF1b":["R240M"]},"labels":{"aa":"ORF1a: W646L; ORF1b: R240M"}}},{"name":"AY.118","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.118"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.118"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-04"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.8734261989593506}},"branch_attrs":{"mutations":{"nuc":["A1C","T826C","A27338T"],"ORF6":["E46V"]},"labels":{"aa":"ORF6: E46V"}}},{"name":"AY.126","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.126"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.126"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.6275558471679688}},"branch_attrs":{"mutations":{"nuc":["A1T","C14925T","A21137G","A24110C","A25439C"],"ORF1b":["K2557R"],"ORF3a":["K16T"],"S":["I850L"]},"labels":{"aa":"ORF1b: K2557R; ORF3a: K16T; S: I850L","spike_mutations":"I850L"}}},{"name":"AY.129","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.129"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.129"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1022281646728516}},"branch_attrs":{"mutations":{"nuc":["A21194G","G28001T","T28156C"],"ORF1b":["D2576G"],"ORF8":["I88T"]},"labels":{"aa":"ORF1b: D2576G; ORF8: I88T"}}},{"name":"AY.131","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.131"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.131"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-21"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.790039539337158}},"branch_attrs":{"mutations":{"nuc":["C14407T","G19999T","G22899T","A23064C","T29014C","G29688T"],"ORF1b":["L314F","V2178F"],"S":["G446V","N501T"]},"labels":{"aa":"ORF1b: L314F, V2178F; S: G446V, N501T","spike_mutations":"G446V, N501T"}}},{"name":"AY.132","node_attrs":{"div":48,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.132"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.132"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-28"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.3016180992126465}},"branch_attrs":{"mutations":{"nuc":["G1418A","A2172G","C4754T","C7945T","G11161A","T11488C","G18213A","T19500C","A19908G","C23683T","C25710T","G25855T","C27131T","G27870T","C27881A"],"ORF1a":["A385T","K636R","P1497S"],"ORF1b":["M1582I","I2147M"],"ORF3a":["D155Y"],"ORF7b":["E39*","H42Q"]},"labels":{"aa":"ORF1a: A385T, K636R, P1497S; ORF1b: M1582I, I2147M; ORF3a: D155Y; ORF7b: E39*, H42Q"}}},{"name":"AY.92","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.92"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.92"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5235536098480225}},"branch_attrs":{"mutations":{"nuc":["C28657T","C29167T"]}}},{"name":"NODE_0000571","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9998865127563477}},"branch_attrs":{"mutations":{"nuc":["C745T"]}},"children":[{"name":"AY.104","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.104"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.104"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.191296577453613}},"branch_attrs":{"mutations":{"nuc":["T13048C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"AY.108","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.108"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.108"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.212674140930176}},"branch_attrs":{"mutations":{"nuc":["T2C","G370T","C823T","C6828T"],"ORF1a":["S2188F"]},"labels":{"aa":"ORF1a: S2188F"}}}]},{"name":"NODE_0000572","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9742491245269775}},"branch_attrs":{"mutations":{"nuc":["A10691G"],"ORF1a":["I3476V"]},"labels":{"aa":"ORF1a: I3476V"}},"children":[{"name":"AY.116","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.116"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9742491245269775}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.116.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.116.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5009799003601074}},"branch_attrs":{"mutations":{"nuc":["G12071A","C19160T","G20968A"],"ORF1a":["D3936N"],"ORF1b":["S1898F","V2501I"]},"labels":{"aa":"ORF1a: D3936N; ORF1b: S1898F, V2501I"}}}]},{"name":"NODE_0000573","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.260836124420166}},"branch_attrs":{"mutations":{"nuc":["G16914T"]}},"children":[{"name":"AY.114","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.114"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.114"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.435910940170288}},"branch_attrs":{"mutations":{"nuc":["C884T","G19677T"],"ORF1a":["R207C"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1a: R207C; ORF1b: Q2070H"}}},{"name":"AY.85","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.85"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3503634929656982}},"branch_attrs":{"mutations":{"nuc":["A708G","C1825T","T17748A","C25810T","G26428T","C26873T"],"E":["V62F"],"ORF1a":["E148G"],"ORF3a":["L140F"]},"labels":{"aa":"E: V62F; ORF1a: E148G; ORF3a: L140F"}}}]},{"name":"NODE_0000574","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.015812635421753}},"branch_attrs":{"mutations":{"nuc":["A1C","C13168T","C23557T","G25996T"],"ORF3a":["V202L"]},"labels":{"aa":"ORF3a: V202L"}},"children":[{"name":"AY.121","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.121"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.015812635421753}},"branch_attrs":{"mutations":{}}},{"name":"AY.121.1","node_attrs":{"div":46,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.121.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-25"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4786581993103027}},"branch_attrs":{"mutations":{"nuc":["T209C","T6949C","C16726T","C19859T","C21648T","C27638T","C27737T","G28396A","G29690T"],"ORF1b":["H1087Y","A2131V"],"ORF7a":["A82V","T115I"],"ORF9b":["G38D"],"S":["T29I"]},"labels":{"aa":"ORF1b: H1087Y, A2131V; ORF7a: A82V, T115I; ORF9b: G38D; S: T29I","spike_mutations":"T29I"}}}]},{"name":"NODE_0000575","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5549795627593994}},"branch_attrs":{"mutations":{"nuc":["C1593T","A10323G","C21301A"],"ORF1a":["S443F","K3353R"],"ORF1b":["P2612T"]},"labels":{"aa":"ORF1a: S443F, K3353R; ORF1b: P2612T"}},"children":[{"name":"AY.124.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.124.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":35},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.1392822265625}},"branch_attrs":{"mutations":{"nuc":["C4276T","G25445T","G25720T","C26058T","G28628T"],"N":["A119S"],"ORF3a":["G18V","A110S"]},"labels":{"aa":"N: A119S; ORF3a: G18V, A110S"}}},{"name":"AY.124","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.124"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-23"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5549795627593994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000576","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.08727502822876}},"branch_attrs":{"mutations":{"nuc":["G15906T"],"ORF1b":["Q813H"]},"labels":{"aa":"ORF1b: Q813H"}},"children":[{"name":"AY.125","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.125"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.125"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.753838300704956}},"branch_attrs":{"mutations":{"nuc":["C745T","C6730T","C13944T","G18905A","G25471T","A26786G"],"ORF1b":["R1813H"],"ORF3a":["D27Y"]},"labels":{"aa":"ORF1b: R1813H; ORF3a: D27Y"}}},{"name":"AY.128","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.128"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.128"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.398505210876465}},"branch_attrs":{"mutations":{"nuc":["C2973T","G16795T","T28150C"],"ORF1a":["A903V"],"ORF1b":["V1110L"],"ORF8":["F86S"]},"labels":{"aa":"ORF1a: A903V; ORF1b: V1110L; ORF8: F86S"}}}]},{"name":"NODE_0000577","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.111449956893921}},"branch_attrs":{"mutations":{"nuc":["A1T","G25538T","C26054A"],"ORF3a":["G49V","T221K"]},"labels":{"aa":"ORF3a: G49V, T221K"}},"children":[{"name":"AY.127","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.127"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.111449956893921}},"branch_attrs":{"mutations":{}}},{"name":"AY.127.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.127.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.655613422393799}},"branch_attrs":{"mutations":{"nuc":["G242A","T7816C","A19445G","G23608T","C24138A","G28378T"],"ORF1b":["K1993R"],"ORF9b":["R32L"],"S":["T859N"]},"labels":{"aa":"ORF1b: K1993R; ORF9b: R32L; S: T859N","spike_mutations":"T859N"}}}]},{"name":"NODE_0000578","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.579427719116211}},"branch_attrs":{"mutations":{"nuc":["A1G","C5239T","T5514C"],"ORF1a":["V1750A"]},"labels":{"aa":"ORF1a: V1750A"}},"children":[{"name":"AY.29","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.29"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.579427719116211}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.29.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.29.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4895212650299072}},"branch_attrs":{"mutations":{"nuc":["G22081T"],"S":["Q173H"]},"labels":{"aa":"S: Q173H","spike_mutations":"Q173H"}}}]},{"name":"NODE_0000579","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0413548946380615}},"branch_attrs":{"mutations":{"nuc":["G2258A","C12073T","C15237T","C25872T"],"ORF1a":["V665I"]},"labels":{"aa":"ORF1a: V665I"}},"children":[{"name":"AY.42.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.42.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7342679500579834}},"branch_attrs":{"mutations":{"nuc":["T4081A","C23718T","C24374T"],"ORF1a":["S1272R"],"S":["T719I","L938F"]},"labels":{"aa":"ORF1a: S1272R; S: T719I, L938F","spike_mutations":"T719I, L938F"}}},{"name":"AY.42","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.42"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0413548946380615}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000580","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.57420015335083}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}},"children":[{"name":"AY.113","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.113"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.113"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0687098503112793}},"branch_attrs":{"mutations":{"nuc":["A1G","C9165T","A10323G","A12772G"],"ORF1a":["T2967I","K3353R"]},"labels":{"aa":"ORF1a: T2967I, K3353R"}}},{"name":"NODE_0000581","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5571038722991943}},"branch_attrs":{"mutations":{"nuc":["C9559T","T28007C"]}},"children":[{"name":"AY.100","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.100"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.100"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.274301290512085}},"branch_attrs":{"mutations":{"nuc":["G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}}},{"name":"AY.101","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.101"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.101"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.416262626647949}},"branch_attrs":{"mutations":{"nuc":["C925T","C9474T","C25460T"],"ORF1a":["A3070V"],"ORF3a":["A23V"]},"labels":{"aa":"ORF1a: A3070V; ORF3a: A23V"}}}]}]},{"name":"NODE_0000582","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9556076526641846}},"branch_attrs":{"mutations":{"nuc":["C8829T","G19006T"],"ORF1a":["A2855V"],"ORF1b":["A1847S"]},"labels":{"aa":"ORF1a: A2855V; ORF1b: A1847S"}},"children":[{"name":"AY.119","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-04"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9556076526641846}},"branch_attrs":{"mutations":{}}},{"name":"AY.119.1","node_attrs":{"div":44,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":38},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.377321720123291}},"branch_attrs":{"mutations":{"nuc":["C100T","C2973T","G17338T","C22227T","T24063C","G25552T","G26031T","T26621C","G29392T"],"N":["K373N"],"ORF1a":["A903V"],"ORF1b":["A1291S"],"ORF3a":["A54S","Q213H"],"S":["A222V","I834T"]},"labels":{"aa":"N: K373N; ORF1a: A903V; ORF1b: A1291S; ORF3a: A54S, Q213H; S: A222V, I834T","spike_mutations":"A222V, I834T"}}},{"name":"AY.119.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1326918601989746}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000583","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.408951759338379}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"AY.36","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.36"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9737071990966797}},"branch_attrs":{"mutations":{"nuc":["T15628C","G18079T","A20532G","C29738T"],"ORF1b":["C721R","V1538L"]},"labels":{"aa":"ORF1b: C721R, V1538L"}}},{"name":"NODE_0000584","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.006218194961548}},"branch_attrs":{"mutations":{"nuc":["C2061T"],"ORF1a":["A599V"]},"labels":{"aa":"ORF1a: A599V"}},"children":[{"name":"AY.20","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.20"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.006218194961548}},"branch_attrs":{"mutations":{}}},{"name":"AY.20.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.20.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6867918968200684}},"branch_attrs":{"mutations":{"nuc":["C8880T","G9190T","C11173T","C24106T","G25481T","C27393T","G29737T"],"ORF1a":["T2872M"],"ORF3a":["R30L"]},"labels":{"aa":"ORF1a: T2872M; ORF3a: R30L"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1764931678771973}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"AY.22","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.22"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.319343566894531}},"branch_attrs":{"mutations":{"nuc":["T12496C","G14209T","A21987G","G22216T","G24872T","G26062T"],"ORF1b":["V248F"],"ORF3a":["G224C"],"S":["D142G","Q218H","V1104L"]},"labels":{"aa":"ORF1b: V248F; ORF3a: G224C; S: D142G, Q218H, V1104L","spike_mutations":"D142G, Q218H, V1104L"}}},{"name":"NODE_0000586","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5547027587890625}},"branch_attrs":{"mutations":{"nuc":["G1495T","A27690T","C29836T"]}},"children":[{"name":"AY.102","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5547027587890625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000587","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.114130020141602}},"branch_attrs":{"mutations":{"nuc":["A21987G","T25333C","A29700G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.102.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-5.037963390350342}},"branch_attrs":{"mutations":{"nuc":["G25218T"],"S":["G1219V"]},"labels":{"aa":"S: G1219V","spike_mutations":"G1219V"}}},{"name":"AY.102.2","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.796270847320557}},"branch_attrs":{"mutations":{"nuc":["C26395A","G29861T","G29862A","T29867-"],"E":["L51I"]},"labels":{"aa":"E: L51I"}}}]}]}]},{"name":"NODE_0000588","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0078787803649902}},"branch_attrs":{"mutations":{"nuc":["C6408T","A25003G"],"ORF1a":["S2048F"]},"labels":{"aa":"ORF1a: S2048F"}},"children":[{"name":"AY.120","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0078787803649902}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.1","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5417470932006836}},"branch_attrs":{"mutations":{"nuc":["C11095T"]}}},{"name":"NODE_0000589","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.590936183929443}},"branch_attrs":{"mutations":{"nuc":["G174T","C21758T"],"S":["H66Y"]},"labels":{"aa":"S: H66Y","spike_mutations":"H66Y"}},"children":[{"name":"AY.120.2","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.590936183929443}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.2.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.8597543239593506}},"branch_attrs":{"mutations":{"nuc":["C7105T","C13138T","T27017A"]}}}]}]},{"name":"NODE_0000590","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.438511610031128}},"branch_attrs":{"mutations":{"nuc":["A1G","G9441T","G18255T","C22498T","G23593C","G26109A","C26681T","G27014T"],"ORF1a":["C3059F"],"ORF1b":["M1596I"],"S":["Q677H"]},"labels":{"aa":"ORF1a: C3059F; ORF1b: M1596I; S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"AY.34","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.438511610031128}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.2","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":35},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.642725944519043}},"branch_attrs":{"mutations":{"nuc":["G11417T","A14457G","C21110T","C24138T"],"ORF1a":["V3718F"],"ORF1b":["T2548I"],"S":["T859I"]},"labels":{"aa":"ORF1a: V3718F; ORF1b: T2548I; S: T859I","spike_mutations":"T859I"}}},{"name":"NODE_0000591","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6367361545562744}},"branch_attrs":{"mutations":{"nuc":["C25355T","C28961T"],"N":["L230F"],"S":["L1265F"]},"labels":{"aa":"N: L230F; S: L1265F","spike_mutations":"L1265F"}},"children":[{"name":"AY.34.1.1","node_attrs":{"div":46,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.820716381072998}},"branch_attrs":{"mutations":{"nuc":["C2106T","G8017T","A21987G"],"ORF1a":["T614I"],"S":["D142G"]},"labels":{"aa":"ORF1a: T614I; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.34.1","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6367361545562744}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000592","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.79569411277771}},"branch_attrs":{"mutations":{"nuc":["G21372T","G27604A"],"ORF1b":["Q2635H"],"ORF7a":["V71I"]},"labels":{"aa":"ORF1b: Q2635H; ORF7a: V71I"}},"children":[{"name":"AY.39","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.79569411277771}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.2","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7347331047058105}},"branch_attrs":{"mutations":{"nuc":["G2494T","G5716T","C6883T","A21987G","G24781C"],"ORF1a":["E743D","K1817N"],"S":["D142G","K1073N"]},"labels":{"aa":"ORF1a: E743D, K1817N; S: D142G, K1073N","spike_mutations":"D142G, K1073N"}}},{"name":"NODE_0000593","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.059364080429077}},"branch_attrs":{"mutations":{"nuc":["A13482G"]}},"children":[{"name":"AY.39.1.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:78-122"},"partiallyAliased":{"value":"B.1.617.2.39.1.3"},"totalAminoacidDeletions":{"value":11},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.902846097946167}},"branch_attrs":{"mutations":{"nuc":["G2164T","A21987G","C25046G","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF1a":["E633D"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"S":["D142G","P1162A"]},"labels":{"aa":"ORF1a: E633D; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; S: D142G, P1162A","spike_mutations":"D142G, P1162A"}}},{"name":"AY.39.1.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:78-122"},"partiallyAliased":{"value":"B.1.617.2.39.1.2"},"totalAminoacidDeletions":{"value":11},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.295774221420288}},"branch_attrs":{"mutations":{"nuc":["G1577A","C18555T","C25568T","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF1a":["V438I"],"ORF3a":["A59V"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"]},"labels":{"aa":"ORF1a: V438I; ORF3a: A59V; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-"}}},{"name":"AY.39.1","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.059364080429077}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.1.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3977465629577637}},"branch_attrs":{"mutations":{"nuc":["G19563T"],"ORF1b":["L2032F"]},"labels":{"aa":"ORF1b: L2032F"}}}]}]},{"name":"NODE_0000594","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7977098226547241}},"branch_attrs":{"mutations":{"nuc":["C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}},"children":[{"name":"AY.4","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7977098226547241}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.10","node_attrs":{"div":44,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.10"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-22"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.931220293045044}},"branch_attrs":{"mutations":{"nuc":["C4320T","C5512T","T8604C","C10714T","C12513T","A16602G","G20663A","C23996T","G25757T","T27900C"],"ORF1a":["A1352V","F2780S","T4083M"],"ORF1b":["S2399N"],"ORF3a":["R122I"],"ORF8":["F3L"],"S":["P812S"]},"labels":{"aa":"ORF1a: A1352V, F2780S, T4083M; ORF1b: S2399N; ORF3a: R122I; ORF8: F3L; S: P812S","spike_mutations":"P812S"}}},{"name":"AY.4.4","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6386144161224365}},"branch_attrs":{"mutations":{"nuc":["G14209T","C21575T","C22000T","G24348C"],"ORF1b":["V248F"],"S":["L5F","S929T"]},"labels":{"aa":"ORF1b: V248F; S: L5F, S929T","spike_mutations":"L5F, S929T"}}},{"name":"AY.4.3","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-08"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5429084300994873}},"branch_attrs":{"mutations":{"nuc":["C21638T"],"S":["P26S"]},"labels":{"aa":"S: P26S","spike_mutations":"P26S"}}},{"name":"AY.4.5","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.983483076095581}},"branch_attrs":{"mutations":{"nuc":["A14882C","G25337T"],"ORF1b":["D472A"],"S":["D1259Y"]},"labels":{"aa":"ORF1b: D472A; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"AY.4.7","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.372633218765259}},"branch_attrs":{"mutations":{"nuc":["A1T","G14829T","G17193T","G26416T","C28291T"],"E":["V58F"],"ORF1b":["M454I","E1242D"],"ORF9b":["P3L"]},"labels":{"aa":"E: V58F; ORF1b: M454I, E1242D; ORF9b: P3L"}}},{"name":"AY.4.8","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.8"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.532318353652954}},"branch_attrs":{"mutations":{"nuc":["C2706T","C11450A","A12124G","G25489T","C29774T"],"ORF1a":["T814I","Q3729K"],"ORF3a":["A33S"]},"labels":{"aa":"ORF1a: T814I, Q3729K; ORF3a: A33S"}}},{"name":"NODE_0000595","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.684542179107666}},"branch_attrs":{"mutations":{"nuc":["T17040C"]}},"children":[{"name":"AY.4.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.0368428230285645}},"branch_attrs":{"mutations":{"nuc":["C2706T","T18927C","A20374C","G22899T"],"ORF1a":["T814I"],"ORF1b":["I2303L"],"S":["G446V"]},"labels":{"aa":"ORF1a: T814I; ORF1b: I2303L; S: G446V","spike_mutations":"G446V"}}},{"name":"AY.4.6","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1065709590911865}},"branch_attrs":{"mutations":{"nuc":["C16293T","C19524T","C20404T","A28967G"],"N":["S232G"],"ORF1b":["P2313S"]},"labels":{"aa":"N: S232G; ORF1b: P2313S"}}},{"name":"AY.4.9","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.9"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-22"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.86684250831604}},"branch_attrs":{"mutations":{"nuc":["C3140T","T4066A","C12513T"],"ORF1a":["P959S","T4083M"]},"labels":{"aa":"ORF1a: P959S, T4083M"}}},{"name":"NODE_0000596","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.5733251571655273}},"branch_attrs":{"mutations":{"nuc":["T21995C","C22227T","C25614T"],"S":["Y145H","A222V"]},"labels":{"aa":"S: Y145H, A222V","spike_mutations":"Y145H, A222V"}},"children":[{"name":"AY.4.2","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-04"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.5733251571655273}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.2.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4524967670440674}},"branch_attrs":{"mutations":{"nuc":["G26526T"],"M":["A2S"]},"labels":{"aa":"M: A2S"}}},{"name":"AY.4.2.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.774232864379883}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"AY.4.2.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.891268491744995}},"branch_attrs":{"mutations":{"nuc":["C15720T","C18687T","G21668T","G28878T"],"N":["S202I"],"S":["V36F"]},"labels":{"aa":"N: S202I; S: V36F","spike_mutations":"V36F"}}}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000597","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{"nuc":["G28881A","G28882A","G28883C"],"N":["R203K","G204R"]},"labels":{"aa":"N: R203K, G204R","clade":"20B"}},"children":[{"name":"B.1.1","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.111","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.111"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.111"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.088804244995117}},"branch_attrs":{"mutations":{"nuc":["T27447C","T29661C"]}}},{"name":"B.1.1.115","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.115"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.115"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5503621101379395}},"branch_attrs":{"mutations":{"nuc":["G26918T","T29464C"]}}},{"name":"B.1.1.101","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.101"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.101"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.795865058898926}},"branch_attrs":{"mutations":{"nuc":["G8371T","G29868A"],"ORF1a":["Q2702H"]},"labels":{"aa":"ORF1a: Q2702H"}}},{"name":"B.1.1.117","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.117"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.117"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5670976638793945}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"B.1.1.135","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.135"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.135"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.479676723480225}},"branch_attrs":{"mutations":{"nuc":["C10376T"],"ORF1a":["P3371S"]},"labels":{"aa":"ORF1a: P3371S"}}},{"name":"B.1.1.121","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.121"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.121"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.165002346038818}},"branch_attrs":{"mutations":{"nuc":["C27538T"]}}},{"name":"B.1.1.133","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.133"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.133"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4965T","A8072G","A16011G","A21213G"],"ORF1a":["T1567I","N2603D"]},"labels":{"aa":"ORF1a: T1567I, N2603D"}}},{"name":"B.1.1.141","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.141"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.141"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.263731002807617}},"branch_attrs":{"mutations":{"nuc":["T22020C","G26056T"],"ORF3a":["D222Y"],"S":["M153T"]},"labels":{"aa":"ORF3a: D222Y; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.157","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.157"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.157"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.143161773681641}},"branch_attrs":{"mutations":{"nuc":["C6145T","G11272A","C17678T"],"ORF1a":["M3669I"],"ORF1b":["T1404M"]},"labels":{"aa":"ORF1a: M3669I; ORF1b: T1404M"}}},{"name":"B.1.1.161","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.161"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.161"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.087497711181641}},"branch_attrs":{"mutations":{"nuc":["G23403A"],"S":["G614D"]},"labels":{"aa":"S: G614D","spike_mutations":"G614D"}}},{"name":"B.1.1.171","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.171"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.171"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7598371505737305}},"branch_attrs":{"mutations":{"nuc":["C1437T","G29745T"],"ORF1a":["S391F"]},"labels":{"aa":"ORF1a: S391F"}}},{"name":"B.1.1.163","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.163"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.163"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.996797561645508}},"branch_attrs":{"mutations":{"nuc":["G11029A","C21772T","C29518T"]}}},{"name":"B.1.1.174","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.174"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.174"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.569986343383789}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.1.176","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.176"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.176"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.818801164627075}},"branch_attrs":{"mutations":{"nuc":["C8208T","G9267A","T9667C","G25947T","G28361A"],"N":["G30R"],"ORF1a":["T2648I","S3001N"],"ORF3a":["Q185H"],"ORF9b":["M26I"]},"labels":{"aa":"N: G30R; ORF1a: T2648I, S3001N; ORF3a: Q185H; ORF9b: M26I"}}},{"name":"B.1.1.186","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.186"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.186"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.552790641784668}},"branch_attrs":{"mutations":{"nuc":["C4113T","G21974C","C23191T"],"ORF1a":["A1283V"],"S":["D138H"]},"labels":{"aa":"ORF1a: A1283V; S: D138H","spike_mutations":"D138H"}}},{"name":"B.1.1.189","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.189"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.189"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.426567554473877}},"branch_attrs":{"mutations":{"nuc":["C9430T","C12823T"]}}},{"name":"B.1.1.192","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.192"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.192"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.35951042175293}},"branch_attrs":{"mutations":{"nuc":["A1G","C673T"]}}},{"name":"B.1.1.203","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.203"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.203"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.922868251800537}},"branch_attrs":{"mutations":{"nuc":["C23854T"]}}},{"name":"B.1.1.207","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.207"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.207"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.143320560455322}},"branch_attrs":{"mutations":{"nuc":["T9172C","A10948G","C10977T","C23604A","A24874G","G26730T","A26927G"],"M":["V70F"],"ORF1a":["A3571V"],"S":["P681H"]},"labels":{"aa":"M: V70F; ORF1a: A3571V; S: P681H","spike_mutations":"P681H"}}},{"name":"B.1.1.198","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.198"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.198"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.466541767120361}},"branch_attrs":{"mutations":{"nuc":["C3261T","A15984T","C20946T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}}},{"name":"B.1.1.205","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.205"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.205"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7890214920043945}},"branch_attrs":{"mutations":{"nuc":["G5539A","G21468A"],"ORF1b":["M2667I"]},"labels":{"aa":"ORF1b: M2667I"}}},{"name":"B.1.1.228","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.228"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.228"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.376809597015381}},"branch_attrs":{"mutations":{"nuc":["A20288G","C21721T","C26894T","C28638A"],"N":["P122H"],"ORF1b":["E2274G"]},"labels":{"aa":"N: P122H; ORF1b: E2274G"}}},{"name":"B.1.1.232","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.232"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.232"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.283544063568115}},"branch_attrs":{"mutations":{"nuc":["T2537G","G12191T","T16479C"],"ORF1a":["L758V","V3976F"]},"labels":{"aa":"ORF1a: L758V, V3976F"}}},{"name":"B.1.1.231","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.231"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.231"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.253881931304932}},"branch_attrs":{"mutations":{"nuc":["A1G","A25505C"],"ORF3a":["Q38P"]},"labels":{"aa":"ORF3a: Q38P"}}},{"name":"B.1.1.253","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.253"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.253"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5750203132629395}},"branch_attrs":{"mutations":{"nuc":["T19893C"]}}},{"name":"B.1.1.241","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.241"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.241"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.247255802154541}},"branch_attrs":{"mutations":{"nuc":["A11782G","T21570G","C21575T","T25473C","C28253T"],"S":["V3G","L5F"]},"labels":{"aa":"S: V3G, L5F","spike_mutations":"V3G, L5F"}}},{"name":"B.1.1.243","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.243"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.243"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7952799797058105}},"branch_attrs":{"mutations":{"nuc":["C5339T","A9900C","C12733A"],"ORF1a":["P1692S","N3212T"]},"labels":{"aa":"ORF1a: P1692S, N3212T"}}},{"name":"B.1.1.263","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.263"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.263"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.34738302230835}},"branch_attrs":{"mutations":{"nuc":["G5924A","T21775G"],"ORF1a":["V1887I"]},"labels":{"aa":"ORF1a: V1887I"}}},{"name":"B.1.1.265","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.265"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.265"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.462660312652588}},"branch_attrs":{"mutations":{"nuc":["C11005A","A28624T"],"ORF1a":["H3580Q"]},"labels":{"aa":"ORF1a: H3580Q"}}},{"name":"B.1.1.269","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.269"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.269"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.337713718414307}},"branch_attrs":{"mutations":{"nuc":["C5055T","G11851T","G24812T","C26895T"],"M":["H125Y"],"ORF1a":["T1597I","M3862I"],"S":["D1084Y"]},"labels":{"aa":"M: H125Y; ORF1a: T1597I, M3862I; S: D1084Y","spike_mutations":"D1084Y"}}},{"name":"B.1.1.277","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.277"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.277"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1255927085876465}},"branch_attrs":{"mutations":{"nuc":["A1G","T772C","A2869G","C10868T","G15652T","C29095T"],"ORF1b":["D729Y"]},"labels":{"aa":"ORF1b: D729Y"}}},{"name":"B.1.1.274","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.274"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.274"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.412598133087158}},"branch_attrs":{"mutations":{"nuc":["G25912T"],"ORF3a":["G174C"]},"labels":{"aa":"ORF3a: G174C"}}},{"name":"B.1.1.298","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.298"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.298"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.084219455718994}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22920T","C25936T"],"ORF1b":["T730I"],"ORF3a":["H182Y"],"S":["Y453F"]},"labels":{"aa":"ORF1b: T730I; ORF3a: H182Y; S: Y453F","spike_mutations":"Y453F"}}},{"name":"B.1.1.297","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.297"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.297"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.437381267547607}},"branch_attrs":{"mutations":{"nuc":["A20742C","T27922C"],"ORF1b":["Q2425H"],"ORF8":["I10T"]},"labels":{"aa":"ORF1b: Q2425H; ORF8: I10T"}}},{"name":"B.1.1.294","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.294"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.294"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.174857139587402}},"branch_attrs":{"mutations":{"nuc":["C3373A","C6883T","G21724A"],"ORF1a":["D1036E"]},"labels":{"aa":"ORF1a: D1036E"}}},{"name":"B.1.1.307","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.307"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.307"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8598484992980957}},"branch_attrs":{"mutations":{"nuc":["G1210T","G9802T","G12067T"],"ORF1a":["M315I","M3934I"]},"labels":{"aa":"ORF1a: M315I, M3934I"}}},{"name":"B.1.1.311","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.311"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.311"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8074538707733154}},"branch_attrs":{"mutations":{"nuc":["G11230T","T24088C","G25617T"],"ORF1a":["M3655I"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1a: M3655I; ORF3a: K75N"}}},{"name":"B.1.1.329","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.329"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.329"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.522205352783203}},"branch_attrs":{"mutations":{"nuc":["A2132C","A10323G","G10360A"],"ORF1a":["K623Q","K3353R"]},"labels":{"aa":"ORF1a: K623Q, K3353R"}}},{"name":"B.1.1.348","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.348"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.348"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.965911388397217}},"branch_attrs":{"mutations":{"nuc":["C25521T","C29870A"]}}},{"name":"B.1.1.359","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.359"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.359"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.385677337646484}},"branch_attrs":{"mutations":{"nuc":["A28305G"],"N":["N11S"],"ORF9b":["M8V"]},"labels":{"aa":"N: N11S; ORF9b: M8V"}}},{"name":"B.1.1.37","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.37"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.37"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.5076286792755127}},"branch_attrs":{"mutations":{"nuc":["C21637T","A28169G"]}}},{"name":"B.1.1.368","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.368"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.368"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.436727523803711}},"branch_attrs":{"mutations":{"nuc":["C9996T","G27798T","G29402T"],"N":["D377Y"],"ORF1a":["S3244L"],"ORF7b":["A15S"]},"labels":{"aa":"N: D377Y; ORF1a: S3244L; ORF7b: A15S"}}},{"name":"B.1.1.370","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.370"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.370"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.374","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.374"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.374"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C344A","T1456C","C8595T","C8836T","G11222T","C22792T","T22917A","T26047G"],"ORF1a":["L27I","T2777I","V3653F"],"ORF3a":["L219V"],"S":["L452Q"]},"labels":{"aa":"ORF1a: L27I, T2777I, V3653F; ORF3a: L219V; S: L452Q","spike_mutations":"L452Q"}}},{"name":"B.1.1.376","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.376"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.376"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.826653480529785}},"branch_attrs":{"mutations":{"nuc":["A6716G","G11596T"],"ORF1a":["S2151G","Q3777H"]},"labels":{"aa":"ORF1a: S2151G, Q3777H"}}},{"name":"B.1.1.39","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.39"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9360604286193848}},"branch_attrs":{"mutations":{"nuc":["G9130T","T27319C","G28487A","C28868T"],"N":["V72I","P199S"]},"labels":{"aa":"N: V72I, P199S"}}},{"name":"B.1.1.378","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.378"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.378"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.596437454223633}},"branch_attrs":{"mutations":{"nuc":["C29284T","C29870A"]}}},{"name":"B.1.1.391","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.391"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.391"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.078312397003174}},"branch_attrs":{"mutations":{"nuc":["T7171C","C27002T"]}}},{"name":"B.1.1.398","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.398"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.398"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.419233322143555}},"branch_attrs":{"mutations":{"nuc":["C5806T"]}}},{"name":"B.1.1.409","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.409"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.409"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.411","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.411"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.411"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.413","node_attrs":{"div":16,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.413"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.413"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A604G","C3096T","G13849T","A19020T","G21974T","G22992A","A26741G","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","C28291T","C29311T"],"M":["I73M"],"ORF1a":["S944L"],"ORF1b":["G128C"],"ORF8":["G66-","S67-","K68E"],"ORF9b":["P3L"],"S":["D138Y","S477N"]},"labels":{"aa":"M: I73M; ORF1a: S944L; ORF1b: G128C; ORF8: G66-, S67-, K68E; ORF9b: P3L; S: D138Y, S477N","spike_mutations":"D138Y, S477N"}}},{"name":"B.1.1.432","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.432"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.432"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.086132526397705}},"branch_attrs":{"mutations":{"nuc":["A6985T","C9319T","C12412T","T14313C"]}}},{"name":"B.1.1.419","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.419"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.419"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.420","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.420"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.420"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.130890846252441}},"branch_attrs":{"mutations":{"nuc":["T847C","G3994T","C5178T","C5548T","A11451G","C13694T","T18132C","C21614T","T22882G","A24373G","G25839T","C28310T","T28862A"],"N":["P13S","S197T"],"ORF1a":["T1638I","Q3729R"],"ORF1b":["T76I"],"ORF3a":["W149C"],"S":["L18F","N440K"]},"labels":{"aa":"N: P13S, S197T; ORF1a: T1638I, Q3729R; ORF1b: T76I; ORF3a: W149C; S: L18F, N440K","spike_mutations":"L18F, N440K"}}},{"name":"B.1.1.442","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.442"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.442"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.203185558319092}},"branch_attrs":{"mutations":{"nuc":["A3879-","G3880-","A3881-","T3882-","T3883-","C3884-","C3885-","T3886-","A3887-","A3888-","A3889-","G3890-","A3891-","G3892-","G3893-","A3894-","A3895-","G3896-","T3897-","T3898-","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","A3908-","C13432T","C29409T"],"N":["T379I"],"ORF1a":["E1205-","I1206-","P1207-","K1208-","E1209-","E1210-","V1211-","K1212-","P1213-","F1214-","I1215V"]},"labels":{"aa":"N: T379I; ORF1a: E1205-, I1206-, P1207-, K1208-, E1209-, E1210-, V1211-, K1212-, P1213-, F1214-, I1215V"}}},{"name":"B.1.1.44","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.44"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.44"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.21798849105835}},"branch_attrs":{"mutations":{"nuc":["G28884T"],"N":["R204L"]},"labels":{"aa":"N: R204L"}}},{"name":"B.1.1.485","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.485"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.485"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.884125232696533}},"branch_attrs":{"mutations":{"nuc":["C745T"]}}},{"name":"B.1.1.462","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.462"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.462"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.083774089813232}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.1.487","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.487"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.487"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.523555278778076}},"branch_attrs":{"mutations":{"nuc":["A20374G"],"ORF1b":["I2303V"]},"labels":{"aa":"ORF1b: I2303V"}}},{"name":"B.1.1.500","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.500"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.500"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.359643936157227}},"branch_attrs":{"mutations":{"nuc":["T23689C","C29230T"]}}},{"name":"B.1.1.52","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.52"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.52"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":1},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.163636207580566}},"branch_attrs":{"mutations":{"nuc":["G8T","T9C","A12T","T14222G","T29867A"],"ORF1b":["L252*"]},"labels":{"aa":"ORF1b: L252*"}}},{"name":"B.1.1.525","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.525"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.525"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-18"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1C","T2C","T3478G","C8299T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12781T","A16550C","C16887T","C18252T","T21992-","A21993-","T21994-","G23012A","C23525T","A28271C","G28916T"],"N":["G215C"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF1b":["D1028A"],"S":["Y144-","E484K","H655Y"]},"labels":{"aa":"N: G215C; ORF1a: S3675-, G3676-, F3677-; ORF1b: D1028A; S: Y144-, E484K, H655Y","spike_mutations":"Y144-, E484K, H655Y"}}},{"name":"B.1.1.53","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.53"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.53"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.883930683135986}},"branch_attrs":{"mutations":{"nuc":["G9890T","A20318G"],"ORF1a":["A3209S"],"ORF1b":["E2284G"]},"labels":{"aa":"ORF1a: A3209S; ORF1b: E2284G"}}},{"name":"B.1.1.57","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.57"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.57"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.499952793121338}},"branch_attrs":{"mutations":{"nuc":["C20234T"],"ORF1b":["P2256L"]},"labels":{"aa":"ORF1b: P2256L"}}},{"name":"B.1.1.61","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.61"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.61"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.901400566101074}},"branch_attrs":{"mutations":{"nuc":["G18898T"],"ORF1b":["V1811F"]},"labels":{"aa":"ORF1b: V1811F"}}},{"name":"B.1.1.63","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.63"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.63"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.753174304962158}},"branch_attrs":{"mutations":{"nuc":["C21597T","C29144T"],"S":["S12F"]},"labels":{"aa":"S: S12F","spike_mutations":"S12F"}}},{"name":"B.1.1.83","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.83"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.83"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.398312091827393}},"branch_attrs":{"mutations":{"nuc":["C1420T"]}}},{"name":"B.1.1.99","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.99"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.99"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.941136360168457}},"branch_attrs":{"mutations":{"nuc":["C28005T","C29870A"],"ORF8":["P38S"]},"labels":{"aa":"ORF8: P38S"}}},{"name":"B.1.533","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.533"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.533"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.077569961547852}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"NODE_0000598","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.773193359375}},"branch_attrs":{"mutations":{"nuc":["G26211T"]}},"children":[{"name":"AT.1","node_attrs":{"div":32,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.370.1"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-19"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1392T","G3281T","A3542G","A5176G","C7005A","T9070C","C9778T","C10029T","A11451G","T12620A","C16985A","G17562T","G19180T","C20759T","C21588T","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","A22206G","A22296C","G23012A","G23900A","C24370T","T25675A","C26568A","G28079T","A28271G"],"M":["L16I"],"ORF1a":["S376L","V1006F","T1093A","T2247N","T3255I","Q3729R","S4119T"],"ORF1b":["T1173N","V1905L","A2431V"],"ORF3a":["L95M"],"S":["P9L","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","D215G","H245P","E484K","E780K"]},"labels":{"aa":"M: L16I; ORF1a: S376L, V1006F, T1093A, T2247N, T3255I, Q3729R, S4119T; ORF1b: T1173N, V1905L, A2431V; ORF3a: L95M; S: P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K","spike_mutations":"P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K"}}},{"name":"B.1.1.404","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.404"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.404"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.654805660247803}},"branch_attrs":{"mutations":{"nuc":["T19275A","G20548T","C26534T"],"ORF1b":["D2361Y"]},"labels":{"aa":"ORF1b: D2361Y"}}}]},{"name":"NODE_0000599","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.10"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.217991828918457}},"branch_attrs":{"mutations":{"nuc":["C19170T","G19509A"]}},"children":[{"name":"B.1.1.10","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.217991828918457}},"branch_attrs":{"mutations":{}}},{"name":"L.3","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"L.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.10.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.097334861755371}},"branch_attrs":{"mutations":{"nuc":["C1601T","G4399T","C4543T","G8179T","C8481T","A9453C","C19269T","T22917G","A25026T","G25244T","A26927G"],"ORF1a":["L446F","M1378I","P2739L","Y3063S"],"S":["L452R","Y1155F","V1228L"]},"labels":{"aa":"ORF1a: L446F, M1378I, P2739L, Y3063S; S: L452R, Y1155F, V1228L","spike_mutations":"L452R, Y1155F, V1228L"}}}]},{"name":"NODE_0000600","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.581684589385986}},"branch_attrs":{"mutations":{"nuc":["C9120T"],"ORF1a":["T2952I"]},"labels":{"aa":"ORF1a: T2952I"}},"children":[{"name":"B.1.1.159","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.159"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.159"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.9156622886657715}},"branch_attrs":{"mutations":{"nuc":["G6865T","A9204C","C15237T","C28290T"],"N":["P6L"],"ORF1a":["K2200N","D2980A"],"ORF9b":["P3S"]},"labels":{"aa":"N: P6L; ORF1a: K2200N, D2980A; ORF9b: P3S"}}},{"name":"B.1.1.302","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.302"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.302"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.444321632385254}},"branch_attrs":{"mutations":{"nuc":["C7267T","C18032T","C20233T","G24926T","A27674T","A29350G"],"ORF1b":["T1522I","P2256S"],"ORF7a":["Q94L"],"S":["V1122L"]},"labels":{"aa":"ORF1b: T1522I, P2256S; ORF7a: Q94L; S: V1122L","spike_mutations":"V1122L"}}}]},{"name":"NODE_0000601","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.953939437866211}},"branch_attrs":{"mutations":{"nuc":["C1427T"],"ORF1a":["H388Y"]},"labels":{"aa":"ORF1a: H388Y"}},"children":[{"name":"B.1.1.254","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.254"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.254"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.953939437866211}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.507","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.507"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.507"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.39810848236084}},"branch_attrs":{"mutations":{"nuc":["G1042A","C12253T","G19656A"]}}}]},{"name":"NODE_0000602","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.189764499664307}},"branch_attrs":{"mutations":{"nuc":["G21624T"],"S":["R21I"]},"labels":{"aa":"S: R21I","spike_mutations":"R21I"}},"children":[{"name":"B.1.1.279","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.279"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.279"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.194469451904297}},"branch_attrs":{"mutations":{"nuc":["C1419T","C4158T","C8318A","G18859T"],"ORF1a":["A385V","A1298V","P2685T"],"ORF1b":["A1798S"]},"labels":{"aa":"ORF1a: A385V, A1298V, P2685T; ORF1b: A1798S"}}},{"name":"B.1.1.360","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.360"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.360"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.070791721343994}},"branch_attrs":{"mutations":{"nuc":["G25598T"],"ORF3a":["W69L"]},"labels":{"aa":"ORF3a: W69L"}}}]},{"name":"NODE_0000603","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.919500827789307}},"branch_attrs":{"mutations":{"nuc":["C936T","G3259T"],"ORF1a":["T224I","Q998H"]},"labels":{"aa":"ORF1a: T224I, Q998H"}},"children":[{"name":"B.1.1.304","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.304"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.304"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.919500827789307}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.434","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.434"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.434"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2342G","C11591T","G17122T","C18348T","A26069G"],"ORF1a":["I693V","L3776F"],"ORF1b":["A1219S"],"ORF3a":["E226G"]},"labels":{"aa":"ORF1a: I693V, L3776F; ORF1b: A1219S; ORF3a: E226G"}}}]},{"name":"NODE_0000604","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986992835998535}},"branch_attrs":{"mutations":{"nuc":["C25528T"],"ORF3a":["L46F"]},"labels":{"aa":"ORF3a: L46F"}},"children":[{"name":"B.1.1.326","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.326"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.326"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.312770843505859}},"branch_attrs":{"mutations":{"nuc":["A12C","G4354A","C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}}},{"name":"B.1.1.8","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986992835998535}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000605","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.15211820602417}},"branch_attrs":{"mutations":{"nuc":["G16853T"],"ORF1b":["G1129V"]},"labels":{"aa":"ORF1b: G1129V"}},"children":[{"name":"B.1.1.34","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.34"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.34"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.187512397766113}},"branch_attrs":{"mutations":{"nuc":["C2094T"],"ORF1a":["S610L"]},"labels":{"aa":"ORF1a: S610L"}}},{"name":"B.1.1.382","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.382"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.382"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.577414035797119}},"branch_attrs":{"mutations":{"nuc":["G6368A"],"ORF1a":["G2035R"]},"labels":{"aa":"ORF1a: G2035R"}}}]},{"name":"NODE_0000606","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.365635395050049}},"branch_attrs":{"mutations":{"nuc":["G28077T"],"ORF8":["V62L"]},"labels":{"aa":"ORF8: V62L"}},"children":[{"name":"B.1.1.397","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.397"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.397"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4799723625183105}},"branch_attrs":{"mutations":{"nuc":["G21974T","T22020C","G28975T"],"N":["M234I"],"S":["D138Y","M153T"]},"labels":{"aa":"N: M234I; S: D138Y, M153T","spike_mutations":"D138Y, M153T"}}},{"name":"B.1.1.526","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.526"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.526"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-25"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-8.3259916305542}},"branch_attrs":{"mutations":{"nuc":["G4510T","C8917T","G9389A","C9611T","G12167T","G14622A","C23604A","T24811C","G25250T","G25906T","C29659T"],"ORF1a":["D3042N","L3116F","V3968F"],"ORF3a":["G172C"],"S":["P681H","V1230L"]},"labels":{"aa":"ORF1a: D3042N, L3116F, V3968F; ORF3a: G172C; S: P681H, V1230L","spike_mutations":"P681H, V1230L"}}}]},{"name":"NODE_0000607","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.675731658935547}},"branch_attrs":{"mutations":{"nuc":["T12503C","C29721T"],"ORF1a":["Y4080H"]},"labels":{"aa":"ORF1a: Y4080H"}},"children":[{"name":"B.1.1.448","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.448"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.448"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.675731658935547}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.54","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.54"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.54"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.6780924797058105}},"branch_attrs":{"mutations":{"nuc":["C6762T","G25770T"],"ORF1a":["T2166I"],"ORF3a":["R126S"]},"labels":{"aa":"ORF1a: T2166I; ORF3a: R126S"}}}]},{"name":"NODE_0000608","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.731308460235596}},"branch_attrs":{"mutations":{"nuc":["C21648T"],"S":["T29I"]},"labels":{"aa":"S: T29I","spike_mutations":"T29I"}},"children":[{"name":"B.1.1.486","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.486"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.486"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["C12439T","C23277T","G23593T","G24368A","G25565A","C25624T","T27242C","C27630T","G28975T","G29332T","G29751T"],"N":["M234I"],"ORF3a":["S58N","H78Y"],"ORF6":["I14T"],"S":["T572I","Q677H","D936N"]},"labels":{"aa":"N: M234I; ORF3a: S58N, H78Y; ORF6: I14T; S: T572I, Q677H, D936N","spike_mutations":"T572I, Q677H, D936N"}}},{"name":"B.1.1.67","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.67"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.67"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.89309549331665}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"ORF1a":["D3728N"]},"labels":{"aa":"ORF1a: D3728N"}}}]},{"name":"NODE_0000609","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.003873348236084}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"B.1.1.371","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.371"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.371"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.003873348236084}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000610","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-7.580465316772461}},"branch_attrs":{"mutations":{"nuc":["C13887T","C23248T"]}},"children":[{"name":"B.1.1.153","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.153"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.153"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C1912T","T9151C","C9693T"],"ORF1a":["A3143V"]},"labels":{"aa":"ORF1a: A3143V"}}},{"name":"B.1.1.170","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.170"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.170"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.357182025909424}},"branch_attrs":{"mutations":{"nuc":["C2062T","C5184A","C16456T","C18687T"],"ORF1a":["P1640H"],"ORF1b":["P997S"]},"labels":{"aa":"ORF1a: P1640H; ORF1b: P997S"}}}]}]},{"name":"NODE_0000611","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.207353591918945}},"branch_attrs":{"mutations":{"nuc":["C26060T"],"ORF3a":["T223I"]},"labels":{"aa":"ORF3a: T223I"}},"children":[{"name":"B.1.1.216","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.216"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.216"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.874288558959961}},"branch_attrs":{"mutations":{"nuc":["A1T","C5884T"]}}},{"name":"B.1.1.416","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.416"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.416"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.053168773651123}},"branch_attrs":{"mutations":{"nuc":["C16386T","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"B.1.1.433","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.433"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.433"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.377383232116699}},"branch_attrs":{"mutations":{"nuc":["C313T","G3692T","C5007T","A11991G","G14584A","C14805T","T15114C","C15848T","G20940T","C22993G","G23580C","T23599A","G26217T","G26951C","T27900C"],"ORF1a":["V1143F","T1581M","E3909G"],"ORF1b":["A373T","T794I"],"ORF3a":["L275F"],"ORF8":["F3L"],"S":["S477R","S673T","N679K"]},"labels":{"aa":"ORF1a: V1143F, T1581M, E3909G; ORF1b: A373T, T794I; ORF3a: L275F; ORF8: F3L; S: S477R, S673T, N679K","spike_mutations":"S477R, S673T, N679K"}}}]},{"name":"NODE_0000612","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.322074890136719}},"branch_attrs":{"mutations":{"nuc":["G10265A"],"ORF1a":["G3334S"]},"labels":{"aa":"ORF1a: G3334S"}},"children":[{"name":"B.1.1.27","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.27"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.27"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.765736103057861}},"branch_attrs":{"mutations":{"nuc":["C16293T"]}}},{"name":"B.1.1.301","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.301"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.301"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.301371097564697}},"branch_attrs":{"mutations":{"nuc":["A9433T","A19650G"]}}},{"name":"B.1.1.70","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.70"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.70"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.566112756729126}},"branch_attrs":{"mutations":{"nuc":["A15972G","C19718T","T28759C"],"ORF1b":["T2084I"]},"labels":{"aa":"ORF1b: T2084I"}}}]},{"name":"NODE_0000613","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.842899322509766}},"branch_attrs":{"mutations":{"nuc":["C22675T"]}},"children":[{"name":"B.1.1.273","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.273"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.273"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.872927665710449}},"branch_attrs":{"mutations":{"nuc":["A7064G"],"ORF1a":["R2267G"]},"labels":{"aa":"ORF1a: R2267G"}}},{"name":"B.1.1.412","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.412"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.412"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986691951751709}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"ORF1a":["D3728N"]},"labels":{"aa":"ORF1a: D3728N"}}},{"name":"B.1.1.56","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.56"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.56"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.680346488952637}},"branch_attrs":{"mutations":{"nuc":["T9508C","G23868T","G24794T"],"S":["G769V","A1078S"]},"labels":{"aa":"S: G769V, A1078S","spike_mutations":"G769V, A1078S"}}}]},{"name":"NODE_0000614","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879861831665039}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"B.1.1.312","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.312"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.312"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420843601226807}},"branch_attrs":{"mutations":{"nuc":["C2455T","C14625T","C19018T","A24432T","A28081G"],"ORF1b":["P1851S"],"ORF8":["D63G"],"S":["Q957L"]},"labels":{"aa":"ORF1b: P1851S; ORF8: D63G; S: Q957L","spike_mutations":"Q957L"}}},{"name":"B.1.1.406","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.406"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.406"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.854406833648682}},"branch_attrs":{"mutations":{"nuc":["C683T","C7051T","C7303T","C8964T","G25314T","C29296T","G29744A"],"ORF1a":["S2900L"],"S":["G1251V"]},"labels":{"aa":"ORF1a: S2900L; S: G1251V","spike_mutations":"G1251V"}}},{"name":"B.1.1.417","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.417"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.417"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.553449630737305}},"branch_attrs":{"mutations":{"nuc":["A2871G","C11455T","T12433C","C16997T","C17285T","A17739G","C19017T","G19072T","C20823T","G21800T","C25416T","G29781T"],"ORF1a":["N869S"],"ORF1b":["P1177L","S1273L","D1869Y"],"S":["D80Y"]},"labels":{"aa":"ORF1a: N869S; ORF1b: P1177L, S1273L, D1869Y; S: D80Y","spike_mutations":"D80Y"}}}]},{"name":"NODE_0000615","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.0597028732299805}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}},"children":[{"name":"B.1.1.351","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.351"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.351"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C7231T","A9749G","C10776A","A13867C","A15489G","C16658T","G17815A","C19164T","G21724T","C23604A"],"ORF1a":["K3162E","P3504H"],"ORF1b":["K134Q","T1064I","G1450R"],"S":["L54F","P681H"]},"labels":{"aa":"ORF1a: K3162E, P3504H; ORF1b: K134Q, T1064I, G1450R; S: L54F, P681H","spike_mutations":"L54F, P681H"}}},{"name":"B.1.1.354","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.354"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.354"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.894475221633911}},"branch_attrs":{"mutations":{"nuc":["A1T","G9389A","G28899T"],"N":["R209I"],"ORF1a":["D3042N"]},"labels":{"aa":"N: R209I; ORF1a: D3042N"}}},{"name":"B.1.1.46","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.46"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.46"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["A1C","C1218T","C27110T","T27384C"],"ORF1a":["S318L"]},"labels":{"aa":"ORF1a: S318L"}}}]},{"name":"NODE_0000616","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.25"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1366167068481445}},"branch_attrs":{"mutations":{"nuc":["A1G","A1163T"],"ORF1a":["I300F"]},"labels":{"aa":"ORF1a: I300F"}},"children":[{"name":"B.1.1.25","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.25"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.25"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1366167068481445}},"branch_attrs":{"mutations":{}}},{"name":"D.2","node_attrs":{"div":14,"clade_display":{"value":"20F"},"Nextclade_pango":{"value":"D.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20F"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.25.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20F"},"placement_prior":{"value":-3.0833330154418945}},"branch_attrs":{"mutations":{"nuc":["T7540C","G16647T","C18555T","G22992A","G23401A"],"S":["S477N"]},"labels":{"aa":"S: S477N","clade":"20F","spike_mutations":"S477N"}}},{"name":"NODE_0000617","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.315"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{"nuc":["G1A","T3256C","G14202T","C19718T","C22388T","C26060T","G29227T","C29466T","A29771G"],"N":["A398V"],"ORF1b":["E245D","T2084I"],"ORF3a":["T223I"]},"labels":{"aa":"N: A398V; ORF1b: E245D, T2084I; ORF3a: T223I"}},"children":[{"name":"AD.2","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.315.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.5890538692474365}},"branch_attrs":{"mutations":{"nuc":["C5622T","G19542T"],"ORF1a":["P1786L"],"ORF1b":["M2025I"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: M2025I"}}},{"name":"B.1.1.315","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.315"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.315"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000618","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.33"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8492207527160645}},"branch_attrs":{"mutations":{"nuc":["T27299C","T29148C"],"N":["I292T"],"ORF6":["I33T"]},"labels":{"aa":"N: I292T; ORF6: I33T"}},"children":[{"name":"B.1.1.33","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.33"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8492207527160645}},"branch_attrs":{"mutations":{}}},{"name":"N.3","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.3295159339904785}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"N.4","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.656519889831543}},"branch_attrs":{"mutations":{"nuc":["A1C","A2475G"],"ORF1a":["K737R"]},"labels":{"aa":"ORF1a: K737R"}}},{"name":"N.5","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A298G","C17274T","A22803G","C25904T","G29134A"],"ORF3a":["S171L"],"S":["Q414R"]},"labels":{"aa":"ORF3a: S171L; S: Q414R","spike_mutations":"Q414R"}}},{"name":"N.6","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.9203901290893555}},"branch_attrs":{"mutations":{"nuc":["C5365T","G8137T"]}}},{"name":"N.9","node_attrs":{"div":16,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.9"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["G1264T","C7600T","C7851T","T11078C","G23012A","A27853C","A29882C"],"ORF1a":["A2529V","F3605L"],"ORF7b":["E33A"],"S":["E484K"]},"labels":{"aa":"ORF1a: A2529V, F3605L; ORF7b: E33A; S: E484K","spike_mutations":"E484K"}}}]},{"name":"NODE_0000619","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.563066005706787}},"branch_attrs":{"mutations":{"nuc":["G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.1.523","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.523"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.523"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-16"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["A1087G","A1610G","A2311G","A2969G","G6609T","C9430T","G10961A","G11222T","C13356T","G14126A","C16466T","G16917A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22035-","A22036-","T22478C","T23042C","A23901C","A24078T","C24642T","C25904T","G25993T","A28273T","G28907T"],"N":["G212C"],"ORF1a":["N449D","M902V","R2115I","V3566I","V3653F","T4364I"],"ORF1b":["S220N","P1000L"],"ORF3a":["S171L","V201F"],"S":["E156-","F157-","R158-","F306L","S494P","E780A","D839V","T1027I"]},"labels":{"aa":"N: G212C; ORF1a: N449D, M902V, R2115I, V3566I, V3653F, T4364I; ORF1b: S220N, P1000L; ORF3a: S171L, V201F; S: E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I","spike_mutations":"E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I"}}},{"name":"NODE_0000620","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1T","C3961T","G7798T","C9072T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G20578A","C21846T","T21992-","A21993-","T21994-","T23287C","C23604A","G23948C","C25276A","A27887-","A27888-","C27889-","G27890-","A27891-","A27892-","C27893-","A27894-","T27895-","G27896-","A27897-","A27898-","A27899-","T27900-","T27901-","G28209T","A28271G","C28896-","T28897-","A28898-","C29769T"],"N":["A208-","R209G"],"ORF1a":["K2511N","T2936I","A3209V","S3675-","G3676-","F3677-"],"ORF1b":["V2371M"],"ORF8":["E106*"],"S":["T95I","Y144-","P681H","D796H"]},"labels":{"aa":"N: A208-, R209G; ORF1a: K2511N, T2936I, A3209V, S3675-, G3676-, F3677-; ORF1b: V2371M; ORF8: E106*; S: T95I, Y144-, P681H, D796H","spike_mutations":"T95I, Y144-, P681H, D796H"}},"children":[{"name":"AZ.4","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.4"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2416T","G7829C","T7831A","C17569T","T27384C"],"ORF1a":["V2522L"],"ORF1b":["P1368S"]},"labels":{"aa":"ORF1a: V2522L; ORF1b: P1368S"}}},{"name":"NODE_0000621","node_attrs":{"div":24,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C24382T"]}},"children":[{"name":"AZ.5","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.5"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T1G","G3259T","G6463T","T20994C","C29077T","A29879G"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"NODE_0000622","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.047728061676025}},"branch_attrs":{"mutations":{"nuc":["C10116T"],"ORF1a":["T3284I"]},"labels":{"aa":"ORF1a: T3284I"}},"children":[{"name":"B.1.1.318","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.047728061676025}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000623","node_attrs":{"div":27,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9889705181121826}},"branch_attrs":{"mutations":{"nuc":["A3852T","G21004T"],"ORF1a":["E1196V"],"ORF1b":["A2513S"]},"labels":{"aa":"ORF1a: E1196V; ORF1b: A2513S"}},"children":[{"name":"AZ.1","node_attrs":{"div":29,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.1"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.071262836456299}},"branch_attrs":{"mutations":{"nuc":["C11345T","C11644T"],"ORF1a":["L3694F"]},"labels":{"aa":"ORF1a: L3694F"}}},{"name":"AZ.2","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.2"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.056198596954346}},"branch_attrs":{"mutations":{"nuc":["C10369T","C12400T","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"AZ.3","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.3"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["T11850C"],"ORF1a":["M3862T"]},"labels":{"aa":"ORF1a: M3862T"}}}]}]}]}]}]},{"name":"NODE_0000624","node_attrs":{"div":28,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.706334114074707}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14676T","C15279T","T16176C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23271A","C23604A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","S3675-","G3676-","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["H69-","V70-","Y144-","N501Y","A570D","P681H","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, S3675-, G3676-, F3677-; ORF8: Q27*, R52I, Y73C; S: H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":28,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.706334114074707}},"branch_attrs":{"mutations":{}}},{"name":"Q.1","node_attrs":{"div":29,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.1"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-02"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.273845911026001}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}}},{"name":"Q.2","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.2"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-02"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.9566643238067627}},"branch_attrs":{"mutations":{"nuc":["A1752G","C6636T","G22468T","C25626T","C27752T","C28227T"],"ORF1a":["Y496C","T2124I"],"ORF7a":["T120I"],"ORF8":["H112Y"]},"labels":{"aa":"ORF1a: Y496C, T2124I; ORF7a: T120I; ORF8: H112Y"}}},{"name":"NODE_0000625","node_attrs":{"div":29,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.8349618911743164}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"Q.3","node_attrs":{"div":33,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.3"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-03"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.3964552879333496}},"branch_attrs":{"mutations":{"nuc":["G5023A","G10396T","G20962A","G26730C"],"M":["V70L"],"ORF1a":["M1586I"],"ORF1b":["D2499N"]},"labels":{"aa":"M: V70L; ORF1a: M1586I; ORF1b: D2499N"}}},{"name":"Q.4","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.4"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.756404399871826}},"branch_attrs":{"mutations":{"nuc":["C335T","A4964G","C7224T","A12162G","A23604G"],"ORF1a":["R24C","T1567A","A2320V","Q3966R"],"S":["H681R"]},"labels":{"aa":"ORF1a: R24C, T1567A, A2320V, Q3966R; S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000626","node_attrs":{"div":30,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.7612149715423584}},"branch_attrs":{"mutations":{"nuc":["T15096C","A28095T"],"ORF8":["K68*"]},"labels":{"aa":"ORF8: K68*"}},"children":[{"name":"Q.7","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.7"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-22"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.1349854469299316}},"branch_attrs":{"mutations":{"nuc":["A7069C","A17337G","T18018C","G28884C"],"N":["R204P"],"ORF1a":["E2268D"]},"labels":{"aa":"N: R204P; ORF1a: E2268D"}}},{"name":"Q.8","node_attrs":{"div":35,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.8"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-22"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-4.827495098114014}},"branch_attrs":{"mutations":{"nuc":["C12525T","C19164T","C25096T","A25974C","G29751T"],"ORF1a":["T4087I"],"ORF3a":["E194D"]},"labels":{"aa":"ORF1a: T4087I; ORF3a: E194D"}}}]}]},{"name":"NODE_0000627","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.3056695461273193}},"branch_attrs":{"mutations":{"nuc":["C313T"]}},"children":[{"name":"B.1.1.181","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.181"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.181"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.882154941558838}},"branch_attrs":{"mutations":{"nuc":["C14724T"]}}},{"name":"B.1.1.214","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.214"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.214"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-2.8961265087127686}},"branch_attrs":{"mutations":{"nuc":["C18167T","G21518T","G28975T"],"N":["M234I"],"ORF1b":["P1567L","R2684I"]},"labels":{"aa":"N: M234I; ORF1b: P1567L, R2684I"}}},{"name":"B.1.1.305","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.305"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.305"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.705223083496094}},"branch_attrs":{"mutations":{"nuc":["G28396A"],"ORF9b":["G38D"]},"labels":{"aa":"ORF9b: G38D"}}},{"name":"B.1.1.50","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.50"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.50"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.180130958557129}},"branch_attrs":{"mutations":{"nuc":["G4510A","G15438T","G25785T"],"ORF1b":["M657I"],"ORF3a":["W131C"]},"labels":{"aa":"ORF1b: M657I; ORF3a: W131C"}}},{"name":"B.1.1.51","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.51"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.51"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.485178470611572}},"branch_attrs":{"mutations":{"nuc":["T10453C","C11195T"],"ORF1a":["L3644F"]},"labels":{"aa":"ORF1a: L3644F"}}},{"name":"NODE_0000628","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.781398296356201}},"branch_attrs":{"mutations":{"nuc":["C9286T"]}},"children":[{"name":"B.1.1.284","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.284"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.284"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.229825973510742}},"branch_attrs":{"mutations":{"nuc":["T4346C","C10376T","C14708T","C28725T","G29692T"],"N":["P151L"],"ORF1a":["S1361P","P3371S"],"ORF1b":["A414V"]},"labels":{"aa":"N: P151L; ORF1a: S1361P, P3371S; ORF1b: A414V"}}},{"name":"B.1.1.47","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.47"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.47"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.771064281463623}},"branch_attrs":{"mutations":{"nuc":["C19763T"],"ORF1b":["T2099I"]},"labels":{"aa":"ORF1b: T2099I"}}}]},{"name":"NODE_0000629","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.306"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.095082759857178}},"branch_attrs":{"mutations":{"nuc":["A1C","C5700A"],"ORF1a":["A1812D"]},"labels":{"aa":"ORF1a: A1812D"}},"children":[{"name":"AE.8","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AE.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.943758726119995}},"branch_attrs":{"mutations":{"nuc":["C1347T","C1943T","C6031T","T7153C","G13975T"],"ORF1a":["P361L","R560C"],"ORF1b":["G170C"]},"labels":{"aa":"ORF1a: P361L, R560C; ORF1b: G170C"}}},{"name":"AE.1","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.027614116668701}},"branch_attrs":{"mutations":{"nuc":["C25791T"]}}},{"name":"B.1.1.306","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.306"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.095082759857178}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000630","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.462162494659424}},"branch_attrs":{"mutations":{"nuc":["T19839C"]}},"children":[{"name":"B.1.1.221","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.221"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.221"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.094874382019043}},"branch_attrs":{"mutations":{"nuc":["C21646T","C26846T"]}}},{"name":"B.1.1.220","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.220"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.220"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.653388977050781}},"branch_attrs":{"mutations":{"nuc":["C26681T"]}}},{"name":"B.1.1.291","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.291"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.291"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9558887481689453}},"branch_attrs":{"mutations":{"nuc":["C15933T","C29784T"]}}},{"name":"B.1.1.317","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.317"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.317"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8059520721435547}},"branch_attrs":{"mutations":{"nuc":["C28905T"],"N":["A211V"]},"labels":{"aa":"N: A211V"}}},{"name":"B.1.1.459","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.459"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.459"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.984232425689697}},"branch_attrs":{"mutations":{"nuc":["C16971T","A21137G","C24099T"],"ORF1b":["K2557R"],"S":["A846V"]},"labels":{"aa":"ORF1b: K2557R; S: A846V","spike_mutations":"A846V"}}},{"name":"B.1.1.464","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.464"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.464"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.0467987060546875}},"branch_attrs":{"mutations":{"nuc":["C12025T","C23707T"]}}},{"name":"B.1.1.521","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.521"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.521"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{"nuc":["C4927T","C9693T","C18744T","C23422T"],"ORF1a":["A3143V"]},"labels":{"aa":"ORF1a: A3143V"}}},{"name":"R.1","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"R.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.316.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.1175601482391357}},"branch_attrs":{"mutations":{"nuc":["C14340T","G17551A","C18877T","A19167G","C19274A","G22017T","G23012A","G23868T","T26604C","C27213T","C28833T","G29527T"],"M":["F28L"],"N":["S187L","Q418H"],"ORF1b":["G1362R","P1936H"],"S":["W152L","E484K","G769V"]},"labels":{"aa":"M: F28L; N: S187L, Q418H; ORF1b: G1362R, P1936H; S: W152L, E484K, G769V","spike_mutations":"W152L, E484K, G769V"}}},{"name":"NODE_0000631","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{"nuc":["A23756G"],"S":["T732A"]},"labels":{"aa":"S: T732A","spike_mutations":"T732A"}},"children":[{"name":"B.1.1.222","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.222"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.222"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000632","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.1.1.316","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.316"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.316"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.084819793701172}},"branch_attrs":{"mutations":{"nuc":["C21757T","G23593C","G23756T","G29751T"],"S":["Q677H","A732S"]},"labels":{"aa":"S: Q677H, A732S","spike_mutations":"Q677H, A732S"}}},{"name":"B.1.1.418","node_attrs":{"div":17,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.418"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.418"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["C1812T","A8072G","A10323G","A21194G","C22480T","G24197T","G24415T","G29751C"],"ORF1a":["A516V","N2603D","K3353R"],"ORF1b":["D2576G"],"S":["A879S"]},"labels":{"aa":"ORF1a: A516V, N2603D, K3353R; ORF1b: D2576G; S: A879S","spike_mutations":"A879S"}}}]}]}]},{"name":"NODE_0000633","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.308648586273193}},"branch_attrs":{"mutations":{"nuc":["G10097A","C23731T"],"ORF1a":["G3278S"]},"labels":{"aa":"ORF1a: G3278S"}},"children":[{"name":"B.1.1.369","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.369"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.369"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7873337268829346}},"branch_attrs":{"mutations":{"nuc":["G28580T"],"N":["D103Y"]},"labels":{"aa":"N: D103Y"}}},{"name":"B.1.1.372","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.372"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.372"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.308648586273193}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000634","node_attrs":{"div":12,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-3.7463936805725098}},"branch_attrs":{"mutations":{"nuc":["A1G","C4002T","C13536T"],"ORF1a":["T1246I"]},"labels":{"aa":"ORF1a: T1246I","clade":"20D"}},"children":[{"name":"B.1.1.1","node_attrs":{"div":12,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-3.7463936805725098}},"branch_attrs":{"mutations":{}}},{"name":"C.11","node_attrs":{"div":16,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.11"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.11"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["T3G","T8071C","G13201A","C27804T"]}}},{"name":"C.13","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.13"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.13"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.601921081542969}},"branch_attrs":{"mutations":{"nuc":["A21131G"],"ORF1b":["Q2555R"]},"labels":{"aa":"ORF1b: Q2555R"}}},{"name":"C.14","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.14"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.14"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.61112642288208}},"branch_attrs":{"mutations":{"nuc":["G29179T"]}}},{"name":"C.26","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.26"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.097334861755371}},"branch_attrs":{"mutations":{"nuc":["G1T","T8278C","G12661A","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-","A29866-","T29867-","G29868-","A29869-","C29870-","A29871-","A29872-","A29873-"]}}},{"name":"C.29","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.29"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.6840291023254395}},"branch_attrs":{"mutations":{"nuc":["T27900C"],"ORF8":["F3L"]},"labels":{"aa":"ORF8: F3L"}}},{"name":"C.23","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.23"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.90360689163208}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}}},{"name":"C.32","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.32"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.39810848236084}},"branch_attrs":{"mutations":{"nuc":["C14877T"]}}},{"name":"C.33","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.33"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.331234931945801}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}}},{"name":"C.35","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.0755510330200195}},"branch_attrs":{"mutations":{"nuc":["G1T","G5950T","G19732T"],"ORF1a":["K1895N"],"ORF1b":["V2089F"]},"labels":{"aa":"ORF1a: K1895N; ORF1b: V2089F"}}},{"name":"C.38","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.38"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-28"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A4307C","C4763T","C5812T","G6609T","A9103C","C9286T","A11201G","G11417T","C19862T","C21057T","C21727T","T21752A","G23012A","G23948T","T26112C","T26767C","C27925A","C28311T","C28905T","G29405C"],"M":["I82T"],"N":["P13L","A211V","E378Q"],"ORF1a":["K1348Q","H1500Y","R2115I","E2946D","T3646A","V3718F"],"ORF1b":["A2132V"],"ORF8":["T11K"],"ORF9b":["P10S"],"S":["W64R","E484K","D796Y"]},"labels":{"aa":"M: I82T; N: P13L, A211V, E378Q; ORF1a: K1348Q, H1500Y, R2115I, E2946D, T3646A, V3718F; ORF1b: A2132V; ORF8: T11K; ORF9b: P10S; S: W64R, E484K, D796Y","spike_mutations":"W64R, E484K, D796Y"}}},{"name":"C.4","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["A4G","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"NODE_0000635","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.439589977264404}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"C.16","node_attrs":{"div":16,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.2959184646606445}},"branch_attrs":{"mutations":{"nuc":["G3302A","C9693T","G29422T"],"ORF1a":["E1013K","A3143V"]},"labels":{"aa":"ORF1a: E1013K, A3143V"}}},{"name":"C.40","node_attrs":{"div":23,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"20D"},"qc.frameShifts.frameShifts":{"value":"S:245-246"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"S:245-246,ORF3a:258-276"},"partiallyAliased":{"value":"B.1.1.1.40"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-27"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2094T","A3069G","C9891T","A10982G","A12820G","C16466T","G22205C","T22292-","G22299-","A22300-","A22301-","G22302-","T22303-","C23481T","C24138A","A26161-","A28271-","G28917T"],"N":["G215V"],"ORF1a":["S610L","D935G","A3209V","K3573E"],"ORF1b":["P1000L"],"ORF3a":["N257-"],"S":["D215H","L244-","S247-","S640F","T859N"]},"labels":{"aa":"N: G215V; ORF1a: S610L, D935G, A3209V, K3573E; ORF1b: P1000L; ORF3a: N257-; S: D215H, L244-, S247-, S640F, T859N","spike_mutations":"D215H, L244-, S247-, S640F, T859N"}}}]},{"name":"NODE_0000636","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.998632907867432}},"branch_attrs":{"mutations":{"nuc":["T14345C","G18292T"],"ORF1b":["L293S","A1609S"]},"labels":{"aa":"ORF1b: L293S, A1609S"}},"children":[{"name":"C.2","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.998632907867432}},"branch_attrs":{"mutations":{}}},{"name":"C.2.1","node_attrs":{"div":22,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.2.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["G922T","T8323C","T15437C","C18501T","A23064C","C25624T","C28453T","C29642T"],"ORF1b":["M657T"],"ORF3a":["H78Y"],"ORF9b":["A57V"],"S":["N501T"]},"labels":{"aa":"ORF1b: M657T; ORF3a: H78Y; ORF9b: A57V; S: N501T","spike_mutations":"N501T"}}}]},{"name":"NODE_0000637","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.791934013366699}},"branch_attrs":{"mutations":{"nuc":["C18747T","G29425T"],"N":["Q384H"]},"labels":{"aa":"N: Q384H"}},"children":[{"name":"B.1.1.375","node_attrs":{"div":23,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.375"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.375"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.2221879959106445}},"branch_attrs":{"mutations":{"nuc":["G1A","C2509T","T4002C","C6781T","A10097G","G17027T","G22992A","A23233G","G28048A"],"ORF1a":["I1246T","S3278G"],"ORF1b":["S1187I"],"ORF8":["R52K"],"S":["S477N"]},"labels":{"aa":"ORF1a: I1246T, S3278G; ORF1b: S1187I; ORF8: R52K; S: S477N","spike_mutations":"S477N"}}},{"name":"C.1","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.791934013366699}},"branch_attrs":{"mutations":{}}},{"name":"C.1.2","node_attrs":{"div":30,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.1.2"},"totalAminoacidDeletions":{"value":5},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["G569A","C2485T","C5175T","A7699G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21969T","G22132T","A22206G","C22210T","G22289-","C22290-","T22291-","T22907C","G23012A","A23063T","C23525T","T23599A","C23709T","G26155-","T26156-","T26157-","C28311T","T28516C"],"N":["P13L"],"ORF1a":["E102K","T1637I","S3675-","G3676-","F3677-"],"ORF3a":["V255-"],"ORF9b":["P10S","M78T"],"S":["C136F","R190S","D215G","A243-","Y449H","E484K","N501Y","H655Y","N679K","T716I"]},"labels":{"aa":"N: P13L; ORF1a: E102K, T1637I, S3675-, G3676-, F3677-; ORF3a: V255-; ORF9b: P10S, M78T; S: C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I","spike_mutations":"C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I"}}}]},{"name":"NODE_0000638","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.54981803894043}},"branch_attrs":{"mutations":{"nuc":["G28908T"],"N":["G212V"]},"labels":{"aa":"N: G212V"}},"children":[{"name":"C.36","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.54981803894043}},"branch_attrs":{"mutations":{}}},{"name":"internal_9cca","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G569A","C2841T","G5180A","C7124T","G9203A","G9929A","C11325T","T11337C","C12534T","G16549T","C17766T","C21597T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22016A","A22600C","T22917G","G23593T","G24257T","T26767C","G27882T","A28271-"],"M":["I82T"],"ORF1a":["E102K","A859V","D1639N","P2287S","D2980N","D3222N","S3687L","L3691S","T4090I"],"ORF1b":["D1028Y"],"ORF7b":["A43S"],"S":["S12F","H69-","V70-","W152R","R346S","L452R","Q677H","A899S"]},"labels":{"aa":"M: I82T; ORF1a: E102K, A859V, D1639N, P2287S, D2980N, D3222N, S3687L, L3691S, T4090I; ORF1b: D1028Y; ORF7b: A43S; S: S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S","spike_mutations":"S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S"}},"children":[{"name":"C.36.3.1","node_attrs":{"div":40,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36.3.1"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-26"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C6706T","C17822T","C18189T","G22992A","T24811C","T25729C","A29040G","C29632T"],"N":["K256R"],"ORF1b":["P1452L"],"ORF3a":["Y113H"],"S":["S477N"]},"labels":{"aa":"N: K256R; ORF1b: P1452L; ORF3a: Y113H; S: S477N","spike_mutations":"S477N"}}},{"name":"C.36.3","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36.3"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-26"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000640","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9867C","T22917A","C28253T","A28271C"],"ORF1a":["L3201P"],"S":["L452Q"]},"labels":{"aa":"ORF1a: L3201P; S: L452Q","spike_mutations":"L452Q"}},"children":[{"name":"C.39","node_attrs":{"div":31,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2110T","C4763T","C6726T","C7113T","T7348G","C11345T","C14585T","C15194A","C21588T","G22131A","C22997T","T26038C","C26366T","C27128T","A28742G"],"E":["A41V"],"N":["I157V"],"ORF1a":["H1500Y","T2154I","T2283I","N2361K","L3694F"],"ORF1b":["A373V","A576D"],"ORF3a":["S216P"],"S":["P9L","R190K","P479S"]},"labels":{"aa":"E: A41V; N: I157V; ORF1a: H1500Y, T2154I, T2283I, N2361K, L3694F; ORF1b: A373V, A576D; ORF3a: S216P; S: P9L, R190K, P479S","spike_mutations":"P9L, R190K, P479S"}}},{"name":"NODE_0000641","node_attrs":{"div":28,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37"},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{"nuc":["C7124T","T7424G","C9857T","C10029T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21786T","C21789T","G22299-","A22300-","A22301-","G22302-","T22303-","T22304-","A22305-","T22306-","T22307-","T22308-","G22309-","A22310-","C22311-","T22312-","C22313-","C22314-","T22315-","G22316-","G22317-","T22318-","G22319-","T23031C","C24138A","C26894T","C28271T","C28311T","G28913T","C29311T"],"N":["P13L","G214C"],"ORF1a":["P2287S","F2387V","T3255I","S3675-","G3676-","F3677-"],"ORF9b":["P10S"],"S":["G75V","T76I","R246-","S247-","Y248-","L249-","T250-","P251-","G252-","D253N","F490S","T859N"]},"labels":{"aa":"N: P13L, G214C; ORF1a: P2287S, F2387V, T3255I, S3675-, G3676-, F3677-; ORF9b: P10S; S: G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N","clade":"Lambda","spike_mutations":"G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N"}},"children":[{"name":"C.37","node_attrs":{"div":28,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.37"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-23"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{}}},{"name":"C.37.1","node_attrs":{"div":32,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.37.1"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C20806T","T25760C","A28877T","G28878C"],"ORF3a":["I123T"]},"labels":{"aa":"ORF3a: I123T"}}}]}]}]}]},{"name":"NODE_0000642","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8542699813842773}},"branch_attrs":{"mutations":{"nuc":["G25088T"],"S":["V1176F"]},"labels":{"aa":"S: V1176F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.28","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8542699813842773}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.332","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.332"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.332"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.391775608062744}},"branch_attrs":{"mutations":{"nuc":["A1G","C442A","C6310T","G11417T","C12053T","T16944C","G26062C"],"ORF1a":["V3718F","L3930F"],"ORF3a":["G224R"]},"labels":{"aa":"ORF1a: V3718F, L3930F; ORF3a: G224R"}}},{"name":"P.3","node_attrs":{"div":26,"clade_display":{"value":"21E (Theta)"},"Nextclade_pango":{"value":"P.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21E"},"clade_who":{"value":"Theta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-10"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"21E"},"placement_prior":{"value":-4.444321632385254}},"branch_attrs":{"mutations":{"nuc":["A4926G","C7564A","T9867C","C11308A","C12049T","C12053T","C17074T","C17339T","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","A22356G","G23012A","A23063T","T23341C","C23604A","T24187A","G24836A","C24863T","A27897C","A28271-","C29724T"],"ORF1a":["D1554G","L3201P","D3681E","L3930F"],"ORF1b":["L1203F","A1291V"],"ORF8":["K2Q"],"S":["L141-","G142-","V143-","Y265C","E484K","N501Y","P681H","E1092K","H1101Y"]},"labels":{"aa":"ORF1a: D1554G, L3201P, D3681E, L3930F; ORF1b: L1203F, A1291V; ORF8: K2Q; S: L141-, G142-, V143-, Y265C, E484K, N501Y, P681H, E1092K, H1101Y","clade":"Theta","spike_mutations":"L141-, G142-, V143-, Y265C, E484K, N501Y, P681H, E1092K, H1101Y"}}},{"name":"P.7","node_attrs":{"div":21,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.7"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A1G","C1288T","C7124T","C7765T","G8027T","C9344T","G10870T","G11596T","C12053T","C17172T","C17676T","C25844T","C28311T"],"N":["P13L"],"ORF1a":["P2287S","V2588F","L3027F","Q3777H","L3930F"],"ORF3a":["T151I"],"ORF9b":["P10S"]},"labels":{"aa":"N: P13L; ORF1a: P2287S, V2588F, L3027F, Q3777H, L3930F; ORF3a: T151I; ORF9b: P10S"}}},{"name":"NODE_0000643","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.082197666168213}},"branch_attrs":{"mutations":{"nuc":["C12053T","C28253T"],"ORF1a":["L3930F"]},"labels":{"aa":"ORF1a: L3930F"}},"children":[{"name":"P.2","node_attrs":{"div":17,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.3414323329925537}},"branch_attrs":{"mutations":{"nuc":["C100T","T10667G","C11824T","G23012A","G28628T","G28975T","C29754T"],"N":["A119S","M234I"],"ORF1a":["L3468V"],"S":["E484K"]},"labels":{"aa":"N: A119S, M234I; ORF1a: L3468V; S: E484K","spike_mutations":"E484K"}}},{"name":"P.6","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-27"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C1077T","G2534T","C3736T","C7043T","C8980T","C10029T","A14113G","G21305A","G23587C","G23593T","C24382T","C25665T","G26172T"],"ORF1a":["P271L","V757F","P2260S","T3255I"],"ORF1b":["T216A","R2613H"],"ORF3a":["M260I"],"S":["Q675H","Q677H"]},"labels":{"aa":"ORF1a: P271L, V757F, P2260S, T3255I; ORF1b: T216A, R2613H; ORF3a: M260I; S: Q675H, Q677H","spike_mutations":"Q675H, Q677H"}}}]},{"name":"NODE_0000644","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-6.34883975982666}},"branch_attrs":{"mutations":{"nuc":["C11450A","A28271C"],"ORF1a":["Q3729K"]},"labels":{"aa":"ORF1a: Q3729K"}},"children":[{"name":"P.4","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-25"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A136G","G1811A","C3177T","C9693T","T9867C","C12008T","C12880T","A15932G","G18756T","C20436T","T22054G","C22079A","T22917G","C23673T","A23720G","G25540A","C28253T","C28932T"],"N":["A220V"],"ORF1a":["A516T","P971L","A3143V","L3201P","L3915F"],"ORF1b":["Y822C"],"ORF3a":["V50I"],"S":["N164K","Q173K","L452R","S704L","I720V"]},"labels":{"aa":"N: A220V; ORF1a: A516T, P971L, A3143V, L3201P, L3915F; ORF1b: Y822C; ORF3a: V50I; S: N164K, Q173K, L452R, S704L, I720V","spike_mutations":"N164K, Q173K, L452R, S704L, I720V"}}},{"name":"P.5","node_attrs":{"div":27,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-19"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5175T","C8950T","C9891T","T10264C","C11152T","C13275T","T14103C","C14571T","T21568A","C21602A","C21721T","C21846T","G23012C","A23064C","C24904T","C28271T","C28531T","G28917T"],"N":["G215V"],"ORF1a":["T1637I","A3209V","P4337L"],"ORF9b":["T83I"],"S":["F2L","Q14K","T95I","E484Q","N501T"]},"labels":{"aa":"N: G215V; ORF1a: T1637I, A3209V, P4337L; ORF9b: T83I; S: F2L, Q14K, T95I, E484Q, N501T","spike_mutations":"F2L, Q14K, T95I, E484Q, N501T"}}}]},{"name":"NODE_0000645","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.67503023147583}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21974T","A28877T","G28878C"],"ORF1a":["S3675-","G3676-","F3677-"],"S":["D138Y"]},"labels":{"aa":"ORF1a: S3675-, G3676-, F3677-; S: D138Y","spike_mutations":"D138Y"}},"children":[{"name":"B.1.1.528","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.528"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.528"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-19"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["A1072G","C1449T","C2094T","A3868T","G9526T","G9756A","G16853T","T22912G","C23604G","T25088G","T26767C","C27297T","A28911T","C29303T"],"M":["I82T"],"N":["N213I","P344S"],"ORF1a":["T395I","S610L","Q1201H","M3087I","R3164H"],"ORF1b":["G1129V"],"S":["N450K","P681R","F1176V"]},"labels":{"aa":"M: I82T; N: N213I, P344S; ORF1a: T395I, S610L, Q1201H, M3087I, R3164H; ORF1b: G1129V; S: N450K, P681R, F1176V","spike_mutations":"N450K, P681R, F1176V"}}},{"name":"NODE_0000646","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{"nuc":["T733C","C2749T","C3828T","A5648C","A6319G","A6613G","C12778T","C13860T","G17259T","C21614T","C21621A","C21638T","G22132T","A22812C","G23012A","A23063T","C23525T","C24642T","T26149C","G28167A","C28512G","T29834A"],"N":["P80R"],"ORF1a":["S1188L","K1795Q"],"ORF1b":["E1264D"],"ORF3a":["S253P"],"ORF8":["E92K"],"ORF9b":["Q77E"],"S":["L18F","T20N","P26S","R190S","K417T","E484K","N501Y","H655Y","T1027I"]},"labels":{"aa":"N: P80R; ORF1a: S1188L, K1795Q; ORF1b: E1264D; ORF3a: S253P; ORF8: E92K; ORF9b: Q77E; S: L18F, T20N, P26S, R190S, K417T, E484K, N501Y, H655Y, T1027I","clade":"Gamma","spike_mutations":"L18F, T20N, P26S, R190S, K417T, E484K, N501Y, H655Y, T1027I"}},"children":[{"name":"P.1","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{}}},{"name":"P.1.1","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-08"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.7353131771087646}},"branch_attrs":{"mutations":{"nuc":["T13851C"]}}},{"name":"P.1.11","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.11"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.509119987487793}},"branch_attrs":{"mutations":{"nuc":["C7945T","C23604G"],"S":["P681R"]},"labels":{"aa":"S: P681R","spike_mutations":"P681R"}}},{"name":"P.1.12","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.12"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-23"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{}}},{"name":"P.1.12.1","node_attrs":{"div":43,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.12.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-19"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["T3592C","T14769G","G20925A","A22298G","C22413T","T23599A","C25613T","C25844T","T28251G","C28253T"],"ORF3a":["S74F","T151I"],"ORF8":["F120V"],"S":["R246G","T284I","N679K"]},"labels":{"aa":"ORF3a: S74F, T151I; ORF8: F120V; S: R246G, T284I, N679K","spike_mutations":"R246G, T284I, N679K"}}},{"name":"P.1.14","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.14"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8808484077453613}},"branch_attrs":{"mutations":{"nuc":["A1G","G9105A","C23380T"],"ORF1a":["S2947N"]},"labels":{"aa":"ORF1a: S2947N"}}},{"name":"P.1.15","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.15"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.483485460281372}},"branch_attrs":{"mutations":{"nuc":["A2596G","C18129T"]}}},{"name":"P.1.16","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.16"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.7957029342651367}},"branch_attrs":{"mutations":{"nuc":["A25746G"],"ORF3a":["I118M"]},"labels":{"aa":"ORF3a: I118M"}}},{"name":"P.1.4","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.4"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.011761665344238}},"branch_attrs":{"mutations":{"nuc":["T23599G"],"S":["N679K"]},"labels":{"aa":"S: N679K","spike_mutations":"N679K"}}},{"name":"P.1.6","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.6"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10615T","C15714T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}},{"name":"P.1.7.1","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.7.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T3049C","C10116T","C23604A"],"ORF1a":["T3284I"],"S":["P681H"]},"labels":{"aa":"ORF1a: T3284I; S: P681H","spike_mutations":"P681H"}}},{"name":"NODE_0000647","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.013174533843994}},"branch_attrs":{"mutations":{"nuc":["A1T","C1427T"],"ORF1a":["H388Y"]},"labels":{"aa":"ORF1a: H388Y"}},"children":[{"name":"P.1.10","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.10"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-12"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.013174533843994}},"branch_attrs":{"mutations":{}}},{"name":"P.1.10.1","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.10.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-12"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.112314701080322}},"branch_attrs":{"mutations":{"nuc":["C2841T","G4300T","C13329T","C26873T"],"ORF1a":["A859V","T4355I"]},"labels":{"aa":"ORF1a: A859V, T4355I"}}}]},{"name":"NODE_0000648","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A1T","C346T","C28603T"]}},"children":[{"name":"P.1.17.1","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.17.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A6704G","G19999T","C21707T"],"ORF1a":["N2147D"],"ORF1b":["V2178F"],"S":["H49Y"]},"labels":{"aa":"ORF1a: N2147D; ORF1b: V2178F; S: H49Y","spike_mutations":"H49Y"}}},{"name":"P.1.17","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.17"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000649","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["T592C","A4040G","C9891T"],"ORF1a":["I1259V","A3209V"]},"labels":{"aa":"ORF1a: I1259V, A3209V"}},"children":[{"name":"P.1.8","node_attrs":{"div":42,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.8"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-03"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A20055G","C22971A","C23604G","G25266T","C26039T","G27915T"],"ORF3a":["S216L"],"ORF8":["G8*"],"S":["T470N","P681R","C1235F"]},"labels":{"aa":"ORF3a: S216L; ORF8: G8*; S: T470N, P681R, C1235F","spike_mutations":"T470N, P681R, C1235F"}}},{"name":"P.1.9","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.9"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C6040T","C18647T","G23587C"],"ORF1b":["P1727L"],"S":["Q675H"]},"labels":{"aa":"ORF1b: P1727L; S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000650","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.685761451721191}},"branch_attrs":{"mutations":{"nuc":["C1912T"]}},"children":[{"name":"P.1.13","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.13"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.1822357177734375}},"branch_attrs":{"mutations":{"nuc":["G10610T"],"ORF1a":["V3449F"]},"labels":{"aa":"ORF1a: V3449F"}}},{"name":"P.1.2","node_attrs":{"div":38,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.2"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-26"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.205961227416992}},"branch_attrs":{"mutations":{"nuc":["A2550G","C5724T","G25855T","C28789T"],"ORF1a":["D762G","T1820I"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF1a: D762G, T1820I; ORF3a: D155Y"}}},{"name":"P.1.7","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.7"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.55728816986084}},"branch_attrs":{"mutations":{"nuc":["C16293T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}}]}]}]}]},{"name":"NODE_0000651","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7765681743621826}},"branch_attrs":{"mutations":{"nuc":["C10029T","C22995A","C23604A"],"ORF1a":["T3255I"],"S":["T478K","P681H"]},"labels":{"aa":"ORF1a: T3255I; S: T478K, P681H","spike_mutations":"T478K, P681H"}},"children":[{"name":"B.1.1.519","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.519"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.519"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-2.7773401737213135}},"branch_attrs":{"mutations":{"nuc":["C203T","C222T","C3140T","C10954T","A11117G","C12789T","T19839C","C21306T","A23756G","C29197T"],"ORF1a":["P959S","I3618V","T4175I"],"S":["T732A"]},"labels":{"aa":"ORF1a: P959S, I3618V, T4175I; S: T732A","spike_mutations":"T732A"}}},{"name":"21M","node_attrs":{"div":40,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-3.6954684257507324}},"branch_attrs":{"mutations":{"nuc":["C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","A23013C","A23040G","A23055G","A23063T","T23075C","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C26270T","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-"],"ORF1a":["P3395H","S3675-","G3676-"],"ORF1b":["I1566V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371F","S373P","S375F","K417N","N440K","G446S","S477N","E484A","Q493R","Q498R","N501Y","Y505H","H655Y","N679K","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-; ORF1a: P3395H, S3675-, G3676-; ORF1b: I1566V; ORF9b: P10S, E27-, N28-, A29-; S: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K","clade":"Omicron","spike_mutations":"A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"NODE_0000653","node_attrs":{"div":54,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.9919633865356445}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","clade":"21K","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}},"children":[{"name":"BA.1","node_attrs":{"div":54,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":46},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.9919633865356445}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.12","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.12"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7732186317443848}},"branch_attrs":{"mutations":{"nuc":["A5T","G22487C","C28315T"],"ORF9b":["A11V"],"S":["E309Q"]},"labels":{"aa":"ORF9b: A11V; S: E309Q","spike_mutations":"E309Q"}}},{"name":"BA.1.10","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.10"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.681899070739746}},"branch_attrs":{"mutations":{"nuc":["C21T","A17042G"],"ORF1b":["Y1192C"]},"labels":{"aa":"ORF1b: Y1192C"}}},{"name":"BA.1.19","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.19"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.5513505935668945}},"branch_attrs":{"mutations":{"nuc":["A1G","C21034T"],"ORF1b":["L2523F"]},"labels":{"aa":"ORF1b: L2523F"}}},{"name":"BA.1.18","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.18"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.3796181678771973}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}}},{"name":"BA.1.2","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.660147190093994}},"branch_attrs":{"mutations":{"nuc":["C7420T","C11669T"],"ORF1a":["R3802C"]},"labels":{"aa":"ORF1a: R3802C"}}},{"name":"BA.1.20","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.20"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.5852789878845215}},"branch_attrs":{"mutations":{"nuc":["C11950T","C28472T"],"N":["P67S"]},"labels":{"aa":"N: P67S"}}},{"name":"BA.1.22","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.22"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.776266574859619}},"branch_attrs":{"mutations":{"nuc":["C21T","G3182A","G5515T"],"ORF1a":["E973K"]},"labels":{"aa":"ORF1a: E973K"}}},{"name":"BA.1.23","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.23"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.952954292297363}},"branch_attrs":{"mutations":{"nuc":["G22599C","T22926G","A22935T","C23013T","C23625T"],"S":["R346T","L455W","K458M","A484V","A688V"]},"labels":{"aa":"S: R346T, L455W, K458M, A484V, A688V","spike_mutations":"R346T, L455W, K458M, A484V, A688V"}}},{"name":"BA.1.3","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.336390495300293}},"branch_attrs":{"mutations":{"nuc":["C21T","A3481G","C8645T"],"ORF1a":["H2794Y"]},"labels":{"aa":"ORF1a: H2794Y"}}},{"name":"BA.1.24","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.24"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.808385372161865}},"branch_attrs":{"mutations":{"nuc":["G22580A","G28378T"],"ORF9b":["R32L"],"S":["E340K"]},"labels":{"aa":"ORF9b: R32L; S: E340K","spike_mutations":"E340K"}}},{"name":"BA.1.6","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.6"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.269890308380127}},"branch_attrs":{"mutations":{"nuc":["C21T","C17639T"],"ORF1b":["S1391L"]},"labels":{"aa":"ORF1b: S1391L"}}},{"name":"BA.1.4","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.4"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.153940677642822}},"branch_attrs":{"mutations":{"nuc":["C21T","G23351A"],"S":["V597I"]},"labels":{"aa":"S: V597I","spike_mutations":"V597I"}}},{"name":"BA.1.5","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.5"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.170540809631348}},"branch_attrs":{"mutations":{"nuc":["C21T","C2091T","C24054T"],"ORF1a":["T609I"],"S":["A831V"]},"labels":{"aa":"ORF1a: T609I; S: A831V","spike_mutations":"A831V"}}},{"name":"BA.1.9","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.9"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.14980149269104}},"branch_attrs":{"mutations":{"nuc":["A1C","C21T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BA.1.7","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.7"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.598451852798462}},"branch_attrs":{"mutations":{"nuc":["C21T","C27686T"],"ORF7a":["S98F"]},"labels":{"aa":"ORF7a: S98F"}}},{"name":"BA.1.8","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.8"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.060263156890869}},"branch_attrs":{"mutations":{"nuc":["A1G","C11455T","C23987T","C29666T"],"S":["P809S"]},"labels":{"aa":"S: P809S","spike_mutations":"P809S"}}},{"name":"NODE_0000654","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{"nuc":["G1957T"],"ORF1a":["K564N"]},"labels":{"aa":"ORF1a: K564N"}},"children":[{"name":"BA.1.13","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.13"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.13.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.13.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.6200735569000244}},"branch_attrs":{"mutations":{"nuc":["A3779G","G19684T"],"ORF1a":["N1172D"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1a: N1172D; ORF1b: V2073L"}}}]},{"name":"NODE_0000655","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4473202228546143}},"branch_attrs":{"mutations":{"nuc":["G27762T"],"ORF7b":["E3*"]},"labels":{"aa":"ORF7b: E3*"}},"children":[{"name":"BA.1.21","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.21"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4473202228546143}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.21.1","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.21.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.046947002410889}},"branch_attrs":{"mutations":{"nuc":["T15685A"],"ORF1b":["L740M"]},"labels":{"aa":"ORF1b: L740M"}}}]},{"name":"NODE_0000656","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{"nuc":["A1C","C12786T"],"ORF1a":["T4174I"]},"labels":{"aa":"ORF1a: T4174I"}},"children":[{"name":"BA.1.14","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.14.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.468590497970581}},"branch_attrs":{"mutations":{"nuc":["C11109T"],"ORF1a":["A3615V"]},"labels":{"aa":"ORF1a: A3615V"}}},{"name":"BA.1.14.2","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.215561389923096}},"branch_attrs":{"mutations":{"nuc":["C1812T"],"ORF1a":["A516V"]},"labels":{"aa":"ORF1a: A516V"}}}]},{"name":"NODE_0000657","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{"nuc":["T3104C","C29632T"],"ORF1a":["Y947H"]},"labels":{"aa":"ORF1a: Y947H"}},"children":[{"name":"BA.1.16","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.16.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.663555145263672}},"branch_attrs":{"mutations":{"nuc":["G9758A","G25455A","T25556G"],"ORF1a":["V3165I"],"ORF3a":["V55G"]},"labels":{"aa":"ORF1a: V3165I; ORF3a: V55G"}}},{"name":"BA.1.16.2","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-5.067101955413818}},"branch_attrs":{"mutations":{"nuc":["C21T","T12436C","A28254G"],"ORF8":["I121V"]},"labels":{"aa":"ORF8: I121V"}}}]},{"name":"NODE_0000658","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{"nuc":["A1C","T10135C","C25708T","A29301G"],"N":["D343G"],"ORF3a":["L106F"]},"labels":{"aa":"N: D343G; ORF3a: L106F"}},"children":[{"name":"BA.1.15.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.538003921508789}},"branch_attrs":{"mutations":{"nuc":["A24803G"],"S":["I1081V"]},"labels":{"aa":"S: I1081V","spike_mutations":"I1081V"}}},{"name":"BA.1.15","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.15.3","node_attrs":{"div":61,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.2535817623138428}},"branch_attrs":{"mutations":{"nuc":["C21T","C3602T","C25886T"],"ORF1a":["H1113Y"],"ORF3a":["S165F"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: S165F"}}},{"name":"BA.1.15.2","node_attrs":{"div":60,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.754347085952759}},"branch_attrs":{"mutations":{"nuc":["G22520A","C23444A"],"S":["V320I","Q628K"]},"labels":{"aa":"S: V320I, Q628K","spike_mutations":"V320I, Q628K"}}}]},{"name":"NODE_0000659","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{"nuc":["A1C","G5924A"],"ORF1a":["V1887I"]},"labels":{"aa":"ORF1a: V1887I"}},"children":[{"name":"BA.1.17","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.17.1","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.100674629211426}},"branch_attrs":{"mutations":{"nuc":["C21T","C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}}},{"name":"NODE_0000660","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.2"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.335338592529297}},"branch_attrs":{"mutations":{"nuc":["C1G","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}},"children":[{"name":"BA.1.17.2","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.335338592529297}},"branch_attrs":{"mutations":{}}},{"name":"BD.1","node_attrs":{"div":61,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.2.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4503445625305176}},"branch_attrs":{"mutations":{"nuc":["C21T","C3241T","C23444A"],"S":["Q628K"]},"labels":{"aa":"S: Q628K","spike_mutations":"Q628K"}}}]}]},{"name":"NODE_0000661","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4241011142730713}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}},"children":[{"name":"BA.1.1","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-07"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4241011142730713}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.1.3","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["C4582T","C23934T","A28416G"],"N":["N48S"],"ORF9b":["I45V"],"S":["T791I"]},"labels":{"aa":"N: N48S; ORF9b: I45V; S: T791I","spike_mutations":"T791I"}}},{"name":"BA.1.1.4","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.4"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7377076148986816}},"branch_attrs":{"mutations":{"nuc":["C21T","G16744A","T25711C","C29754T"],"ORF1b":["G1093S"],"ORF3a":["Y107H"]},"labels":{"aa":"ORF1b: G1093S; ORF3a: Y107H"}}},{"name":"NODE_0000662","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.674670696258545}},"branch_attrs":{"mutations":{"nuc":["A1T","A16064G"],"ORF1b":["Q866R"]},"labels":{"aa":"ORF1b: Q866R"}},"children":[{"name":"BA.1.1.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.674670696258545}},"branch_attrs":{"mutations":{}}},{"name":"BC.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.36091685295105}},"branch_attrs":{"mutations":{"nuc":["C5833T","A22259G"],"S":["I233V"]},"labels":{"aa":"S: I233V","spike_mutations":"I233V"}}},{"name":"BC.2","node_attrs":{"div":60,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.884258270263672}},"branch_attrs":{"mutations":{"nuc":["C21T","C13862T","G19348A"],"ORF1b":["T132I","V1961I"]},"labels":{"aa":"ORF1b: T132I, V1961I"}}}]},{"name":"NODE_0000663","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.3621480464935303}},"branch_attrs":{"mutations":{"nuc":["C2470T"]}},"children":[{"name":"BA.1.1.11","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.11"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.2315807342529297}},"branch_attrs":{"mutations":{"nuc":["G2354A"],"ORF1a":["G697R"]},"labels":{"aa":"ORF1a: G697R"}}},{"name":"BA.1.1.10","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.10"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4704771041870117}},"branch_attrs":{"mutations":{"nuc":["C21T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"BA.1.1.12","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.12"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.3868720531463623}},"branch_attrs":{"mutations":{"nuc":["C21T","C2942A"],"ORF1a":["L893M"]},"labels":{"aa":"ORF1a: L893M"}}},{"name":"BA.1.1.13","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.13"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.139563798904419}},"branch_attrs":{"mutations":{"nuc":["C21T","C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"BA.1.1.14","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.14"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.8932130336761475}},"branch_attrs":{"mutations":{"nuc":["A14107G"],"ORF1b":["I214V"]},"labels":{"aa":"ORF1b: I214V"}}},{"name":"BA.1.1.16","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.16"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.8349038362503052}},"branch_attrs":{"mutations":{"nuc":["A1C","C21595T","C27509G"],"ORF7a":["T39R"]},"labels":{"aa":"ORF7a: T39R"}}},{"name":"BA.1.1.17","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.17"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.2085862159729}},"branch_attrs":{"mutations":{"nuc":["G1659T","C5183T"],"ORF1a":["G465V","P1640S"]},"labels":{"aa":"ORF1a: G465V, P1640S"}}},{"name":"BA.1.1.15","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.15"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.933518171310425}},"branch_attrs":{"mutations":{"nuc":["G13570A","G29755C"],"ORF1b":["G35S"]},"labels":{"aa":"ORF1b: G35S"}}},{"name":"BA.1.1.18","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.18"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.329127073287964}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"ORF1a":["A2554V"]},"labels":{"aa":"ORF1a: A2554V"}}},{"name":"BA.1.1.2","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.413982391357422}},"branch_attrs":{"mutations":{"nuc":["C10560G"],"ORF1a":["T3432S"]},"labels":{"aa":"ORF1a: T3432S"}}},{"name":"BA.1.1.5","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.5"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.915313482284546}},"branch_attrs":{"mutations":{"nuc":["C21T","A2589G","C26996T"],"ORF1a":["E775G"]},"labels":{"aa":"ORF1a: E775G"}}},{"name":"BA.1.1.7","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.7"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.486417531967163}},"branch_attrs":{"mutations":{"nuc":["C2453T"],"ORF1a":["L730F"]},"labels":{"aa":"ORF1a: L730F"}}},{"name":"BA.1.1.8","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.8"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.9190704822540283}},"branch_attrs":{"mutations":{"nuc":["C1766A"],"ORF1a":["Q501K"]},"labels":{"aa":"ORF1a: Q501K"}}},{"name":"BA.1.1.9","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.9"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4197943210601807}},"branch_attrs":{"mutations":{"nuc":["C13421T"],"ORF1a":["L4386F"]},"labels":{"aa":"ORF1a: L4386F"}}},{"name":"BA.1.1.6","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.6"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.071193695068359}},"branch_attrs":{"mutations":{"nuc":["C21T","C5144T","C28757T"],"N":["P162S"]},"labels":{"aa":"N: P162S"}}}]}]}]},{"name":"internal_a01b","node_attrs":{"div":51,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.757229804992676}},"branch_attrs":{"mutations":{"nuc":["T670G","G4184A","C4321T","C9534T","G10447A","T11294-","T11295-","T11296-","C12880T","C15714T","G22775A","C26060T","C26858T","A29510C","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["S413R"],"ORF1a":["S135R","G1307S","T3090I","F3677-"],"ORF3a":["T223I"],"S":["D405N"]},"labels":{"aa":"N: S413R; ORF1a: S135R, G1307S, T3090I, F3677-; ORF3a: T223I; S: D405N","spike_mutations":"D405N"}},"children":[{"name":"internal_8b65","node_attrs":{"div":54,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}},"children":[{"name":"BA.3.1","node_attrs":{"div":57,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3.1"},"totalAminoacidDeletions":{"value":15},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-21"},"totalAminoacidSubstitutions":{"value":45},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3791A","C3792A","A22812C"],"ORF1a":["A1176N"],"S":["N417T"]},"labels":{"aa":"ORF1a: A1176N; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.3","node_attrs":{"div":54,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3"},"totalAminoacidDeletions":{"value":15},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-14"},"totalAminoacidSubstitutions":{"value":44},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000666","node_attrs":{"div":70,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9307780265808105}},"branch_attrs":{"mutations":{"nuc":["C2790T","C9344T","A9424G","C10198T","C17410T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21762C","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","T21846C","-21987A","-21988T","-21989G","-21990T","-21991T","-21992T","-21993A","-21994T","-21995T","-22194A","-22195T","-22196T","T22200G","A22688G","A22786C","A22898G","C25000T","C25584T","G27382C","A27383T","T27384C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-"],"ORF1a":["T842I","L3027F"],"ORF1b":["R1315C","T2163I"],"ORF6":["D61L"],"S":["T19I","L24-","P25-","P26-","A27S","V67A","-69H","-70V","I95T","-142D","-143V","-144Y","D145Y","-211N","I212L","V213G","T376A","R408S","S446G"]},"labels":{"aa":"ORF1a: T842I, L3027F; ORF1b: R1315C, T2163I; ORF6: D61L; S: T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G","clade":"21L","spike_mutations":"T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G"}},"children":[{"name":"BA.2","node_attrs":{"div":70,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9307780265808105}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.16","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.223683834075928}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.828702449798584}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.19"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.502110004425049}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":129,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.8217399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.87.1"},"totalAminoacidDeletions":{"value":41},"immune_escape":{"value":"0.6657453429914796"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"NODE_0000668","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4827568531036377}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.958770990371704}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0617406368255615}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9340405464172363}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.24"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.01261797446067892"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.043281078338623}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.26"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5770962238311768}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.28","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.28"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.954390048980713}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.29"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.246047258377075}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.27","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.27"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9474263191223145}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.30","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.30"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.186139106750488}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.32"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.723714828491211}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.39","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.39"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.4","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7227389812469482}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.41","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.41"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7298529148101807}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.42","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.42"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.43"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.411208152770996}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.46","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.46"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.78423547744751}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.48","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.48"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-01"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7899765968322754}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.50"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.211312770843506}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.5","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5876340866088867}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.54","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.54"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.137404441833496}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.58"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.05063533782959}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.55","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.55"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.214793682098389}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.59","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.59"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.600702285766602}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.60","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.60"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.61","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.61"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.497011184692383}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.62"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9947850704193115}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.63","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.63"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17851448059082}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.65","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.65"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8447577953338623}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.64","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.64"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5229573249816895}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.70","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.70"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.472323894500732}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":81,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9213199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.77"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3221048136122174"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.605336666107178}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-28"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.326139211654663}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":89,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.12534"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.83"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.22071783986880583"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.82","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.82"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.2169976234436035}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.85","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.85"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.299220561981201}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000669","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000670","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.123861312866211}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.123861312866211}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.867143630981445}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000672","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.892359733581543}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.35","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.35"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.569701671600342}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.33","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.33"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086283206939697}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}}]},{"name":"internal_ad79","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.795884370803833}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.795884370803833}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.748093843460083}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000674","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9647769927978516}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9647769927978516}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.696688175201416}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"NODE_0000675","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636352777481079}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636352777481079}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.4","node_attrs":{"div":83,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.73328"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3166622371297313"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-09"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.095335006713867}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"BA.2.10.3","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.07940673828125}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.2","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6844911575317383}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"internal_ffa6","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4720098972320557}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4720098972320557}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.09519000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.6181860283242497"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000677","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.6233294010162354}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6388018131256104}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.22"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2793378829956055}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.34"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.040848255157471}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.36"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0697343349456787}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.45","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.45"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-23"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6386520862579346}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.47","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.47"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.130117893218994}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.49"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7807652950286865}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.53","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.53"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.51","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.51"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.694986581802368}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.52"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8800220489501953}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.6","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6629879474639893}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.69"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.939220905303955}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.7","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3562943935394287}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.71","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.71"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.660242795944214}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.72","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.72"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.616490125656128}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10838000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.80"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.31190394480802347"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6446309089660645}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.81"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.347172260284424}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25.1","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.99613094329834}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BA.2.25","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8e5d","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.7391467094421387}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.44"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-21"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.218840599060059}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.024046421051025}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000681","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1916520595550537}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1916520595550537}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":83,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.2","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.620241165161133}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.3","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3528671264648438}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.4","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2389769554138184}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5045342445373535}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":81,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000682","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.10","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.098408222198486}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.11","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7979328632354736}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.12","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.15","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8729300498962402}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.13","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3481757640838623}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.958418846130371}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.17","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8992514610290527}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.19","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.19"},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.70237398147583}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.18","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.462869644165039}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.4","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.5","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3020405769348145}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.7","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.8","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8521335124969482}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":86,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9456899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.43687237373984505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601434707641602}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06758"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.828201770782471}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":87,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"DD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9683399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4733677107846063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000685","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17149543762207}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":85,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.37526000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.22"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.42289430257523936"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0095014572143555}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000687","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.1","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.6589000000000002"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.6029918987948071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.66194"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.49181526572268314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.2","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.66821"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.4975483601650658"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000688","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.8190299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7593324873420084"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000689","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.91683"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7016283989012374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":104,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9440299999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8143059671640498"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.2","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"CM.5.1","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}}]},{"name":"internal_fc49","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.99403"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7255583352017505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000693","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1.2","node_attrs":{"div":103,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.4","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000694","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":104,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000695","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":107,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"FV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.28625999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0761544902802131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.35566999999999993"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0179803928276123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000698","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000699","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9729599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9785485534494837"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000700","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1288509368896484}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.1123433113098145}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.21"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.37"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-03"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.100731134414673}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.57"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.165760517120361}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.66"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.677023410797119}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.68"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.937255382537842}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.73"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0411696434021}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.21698000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.74"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.33134042675697756"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8886804580688477}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.78"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.664361953735352}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000701","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.096076011657715}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.67"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000702","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000703","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000704","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.18492"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.2640232066165751"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4447848796844482}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-06"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4447848796844482}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.08445999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.07383293656037815"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":82,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.370455061085298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.580877304077148}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000707","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.987913131713867}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0862932205200195}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000708","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.91279411315918}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.449609756469727}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07350000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.062348652344665065"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000710","node_attrs":{"div":75,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0579044818878174}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":75,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0579044818878174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000711","node_attrs":{"div":77,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292837142944336}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":80,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.4","node_attrs":{"div":82,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.3","node_attrs":{"div":79,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.5","node_attrs":{"div":79,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-28"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.2","node_attrs":{"div":85,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-18"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.7","node_attrs":{"div":84,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.6","node_attrs":{"div":80,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}}]}]}]},{"name":"NODE_0000712","node_attrs":{"div":88,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":88,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.499692916870117}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.8","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04854"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.544774532318115}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.514627933502197}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.4722700119018555}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.13451"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.4722700119018555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000715","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.378986120223999}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"BR.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b66e","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.24593"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5588825437629772"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000717","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.12575999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7451886007636047"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000718","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.10514"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5013910005227346"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000719","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}},{"name":"BR.5","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000721","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210728645324707}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.16854"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000722","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590982437133789}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590982437133789}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000723","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.19193"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.3464399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.56756"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6011952983295785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.1.2","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.6","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.11979"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5544855553668998"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.681193828582764}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.681193828582764}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_147e","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{}}},{"name":"CA.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.716528415679932}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.4","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.6","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"CA.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"internal_80b8","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.2371799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"NODE_0000730","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096992492675781}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096992492675781}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78438138961792}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.653690335850791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.11385"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5060716304521155"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000733","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.8","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.5340599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9193315170816834"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.7","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"NODE_0000734","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000735","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000736","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1331"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7470314258752732"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.31233"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7815531080803261"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000737","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000738","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":106,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}},{"name":"BN.1.4.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}}]}]},{"name":"NODE_0000739","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.136174201965332}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.220160484313965}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000740","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.21326"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7326886306518271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.4","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.6","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.8","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000741","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000742","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1.2","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.3","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000743","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49798059463501}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.2","node_attrs":{"div":102,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}},{"name":"DS.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.16291"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0513083167390975"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.12","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.9","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.3","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":102,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.6","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}},{"name":"BN.1.3.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}}]}]}]}]}]},{"name":"NODE_0000750","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.6","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"BM.5","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.03087854385376}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000751","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.26994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5272935807019111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"BM.2","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000752","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.78817"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000755","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.43724"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000758","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.87567"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9457248359372292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000759","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3.1","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000761","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000762","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000763","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":104,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000764","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000765","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":118,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000769","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852804660797119}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.0219999999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.36891999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7685109779549473"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":95,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":95,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000773","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"23C"},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"ace2_binding":{"value":"0.08511000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7a:59-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9441222497200389"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000774","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000775","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1.1","node_attrs":{"div":107,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}},{"name":"GQ.1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000776","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.24","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.29","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000777","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"internal_ddb1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":109,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000785","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000786","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.7","node_attrs":{"div":117,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}},{"name":"DV.7.1.6","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}}]},{"name":"internal_38689e19","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":114,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":118,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":119,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000790","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.3","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000791","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000792","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000793","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.3","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}},{"name":"GP.2","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}}]},{"name":"NODE_0000794","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462465286255}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.22","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.23","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.30","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.6","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.8","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000795","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000796","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000797","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000798","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1.1","node_attrs":{"div":115,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}},{"name":"JP.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"internal_7d467e42","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.2","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}},{"name":"FK.1.2.1","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}}]},{"name":"internal_d1673169","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}},{"name":"FK.1.4","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000804","node_attrs":{"div":107,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":109,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}},{"name":"FK.1.1.1","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.16085999999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9815994835819151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_5be7761b","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["T241-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["-241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000807","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000808","node_attrs":{"div":118,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"LV.2","node_attrs":{"div":132,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000809","node_attrs":{"div":120,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.68471097946167}},"branch_attrs":{"mutations":{"nuc":["C21T","T13339C"]}},"children":[{"name":"BA.2.86","node_attrs":{"div":120,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-17"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.68471097946167}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":121,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000810","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}}]},{"name":"NODE_0000811","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-13"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000812","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.6738025507980547"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000813","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000814","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.15919"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-05"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000815","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-20"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":137,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":134,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000816","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.804112911224365}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.519156455993652}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000817","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.16","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.15","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.15"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.17","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.14","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.19","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.19"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.18","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.6","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.8","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"NODE_0000818","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11.1","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.11","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000819","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000820","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","C6525T","C29171T"],"N":["H300Y"],"ORF1a":["P892S","T2087I"]},"labels":{"aa":"N: H300Y; ORF1a: P892S, T2087I"}},"children":[{"name":"JN.3.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.3.2","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000821","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":132,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.6465599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000822","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}}]},{"name":"internal_59b29264","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000824","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000825","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.503751754760742}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000826","node_attrs":{"div":128,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7886734008789062}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":128,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-29"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7886734008789062}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.413212776184082}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.26806999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2179718017578125}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9045636653900146}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063994884490967}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.875786304473877}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.6742007732391357}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4943132400512695}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.498900413513184}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407996654510498}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.0337066650390625}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.46","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.232485294342041}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.45","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2978410720825195}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.5","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.8044490814208984}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.117572784423828}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.344854354858398}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.61","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.93036"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.496607246855186"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4297661781311035}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.67","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.5563645362854}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}}},{"name":"JN.1.66","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086506843566895}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086506843566895}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.2.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.971957206726074}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240969657897949}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-20"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240969657897949}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013700485229492}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.323051452636719}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013700485229492}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.16291618347168}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.16291618347168}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.261717796325684}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.847394943237305}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.847394943237305}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3922882080078125}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3922882080078125}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741697788238525}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.846282005310059}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.44","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741697788238525}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.501391887664795}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.501391887664795}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.05681999999999991"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.532734695870142"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9070000648498535}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9070000648498535}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.56.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.7602899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5395016697354735"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803360939025879}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":8.507},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}},{"name":"JN.1.59","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803360939025879}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235310077667236}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235310077667236}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4939866065979}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000838","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1673784255981445}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.744482040405273}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}},{"name":"JN.1.63","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1673784255981445}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_4e516d94","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.049008369445801}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.049008369445801}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.251441478729248}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.251441478729248}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395014762878418}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395014762878418}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.455239772796631}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332273483276367}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332273483276367}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.063151836395264}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005981922149658}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.993703842163086}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005981922149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.405921936035156}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.405921936035156}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082502841949463}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082502841949463}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.514431953430176}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.514431953430176}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.825034141540527}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"NODE_0000850","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.62","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-08"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","G23604A"],"S":["V62F","R681H"]},"labels":{"aa":"S: V62F, R681H","spike_mutations":"V62F, R681H"}}},{"name":"NODE_0000851","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{"nuc":["G4162A","G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MZ.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9003684520721436}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9003684520721436}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.853470802307129}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.176589012145996}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.56445837020874}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.965569496154785}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.965569496154785}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.303284645080566}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439889430999756}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439889430999756}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MS.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217808246612549}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-18"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"ME.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.27215999999999985"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894906520843506}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894906520843506}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834674835205078}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834674835205078}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000860","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2595099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.2","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}},{"name":"MF.1","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343885898590088}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343885898590088}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000864","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548393249511719}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548393249511719}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693490982055664}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.125247478485107}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566946029663086}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000868","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"internal_137393d6","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000871","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000872","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4388251304626465}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000873","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.779577732086182}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.779577732086182}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753198623657227}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":141,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-20"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.396686553955078}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":96},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000879","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.62368106842041}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.62368106842041}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000880","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000881","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.9318500000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3745641202332524"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000882","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000883","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7748894691467285}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.327071189880371}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7748894691467285}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5151262283325195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000887","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000888","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MV.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.30217999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000889","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309098243713379}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309098243713379}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.409302234649658}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.224720478057861}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.8731584548950195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.8731584548950195}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.486703395843506}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.53473424911499}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.53473424911499}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3433942794799805}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3433942794799805}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917654037475586}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917654037475586}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.225796699523926}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005701065063477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1.3","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.098504066467285}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.57","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_dd754174","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.730973243713379}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.730973243713379}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.287435054779053}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.08313"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.566638469696045}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69068717956543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.6","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.7","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.175660610198975}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.9","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000903","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000904","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}},{"name":"MQ.2","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.04395"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{}}},{"name":"LK.2.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.95433"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.712064027786255}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.776793003082275}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.712064027786255}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.4","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.743773937225342}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1655168533325195}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000909","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.8164446353912354}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0372114181518555}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.78267240524292}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.78267240524292}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000913","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769777297973633}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769777297973633}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145885944366455}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000914","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5280601978302}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5280601978302}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"internal_e3b87428","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6427741050720215}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6427741050720215}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000917","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.973682403564453}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.973682403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621864318847656}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621864318847656}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000921","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227319717407227}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.88560676574707}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.850419044494629}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000922","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000923","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":142,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":11.111},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000924","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.2","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.3","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"internal_3e3e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056468486785889}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056468486785889}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.607524394989014}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.143589496612549}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.143589496612549}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.6","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.9","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"LB.1.8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"NODE_0000928","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.3"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-24"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000929","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.662585735321045}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}},{"name":"LB.1.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.3","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000931","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883640289307}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883640289307}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.472174644470215}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347520351409912}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.416768550872803}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.416768550872803}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LA.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.04741999999999978"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"S":["T346I"]},"labels":{"aa":"S: T346I","spike_mutations":"T346I"}}},{"name":"LA.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685051918029785}},"branch_attrs":{"mutations":{"nuc":["T22599C"]}}}]}]},{"name":"NODE_0000936","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.71908712387085}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012791156768799}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MT.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_acb00454","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.085048198699951}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.085048198699951}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":50.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21767999999999987"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.817229820305529"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LF.3.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}}]}]},{"name":"NODE_0000944","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671684741973877}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671684741973877}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000945","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9.1"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000946","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000947","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}},{"name":"LF.8.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.107455253601074}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.107455253601074}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958076000213623}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958076000213623}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688903331756592}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688903331756592}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.83402681350708}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.83402681350708}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.795686721801758}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":11.111},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3926199999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451968669891357}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451968669891357}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.52098274230957}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}},{"name":"LQ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000957","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.106265068054199}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172470569610596}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172470569610596}},"branch_attrs":{"mutations":{}}},{"name":"LY.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}},{"name":"LY.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}}]},{"name":"NODE_0000960","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]},{"name":"NODE_0000962","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}},{"name":"LZ.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":132,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299810886383057}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":132,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299810886383057}},"branch_attrs":{"mutations":{}}},{"name":"KP.6","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.04741999999999978"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.009568691253662}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"KP.5","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.512091159820557}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000966","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.27333999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7741516492587035"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000970","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679379463195801}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-22"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679379463195801}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MU.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923413038253784}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923413038253784}},"branch_attrs":{"mutations":{}}},{"name":"LP.3","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.4","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_bfd296bd","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928688049316}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928688049316}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000976","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000977","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013410568237305}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013410568237305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.11","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.12","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.1","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.616664409637451}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.19","node_attrs":{"div":140,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.19"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.23"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.24"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.083328723907471}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.0966644287109375}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000981","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7908990401504723"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.4","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.3","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000982","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":140,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MW.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":96},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000983","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.91617751121521}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.21942999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.17","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.16","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.532774448394775}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.18"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.196527481079102}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.22"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000984","node_attrs":{"div":133,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987264633178711}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":133,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987264633178711}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.6","node_attrs":{"div":134,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.770003318786621}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.3.5","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"internal_123a0013","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094734191894531}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094734191894531}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":141,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.2","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5554650921238282"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"KP.3.3.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"NODE_0000987","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MR.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9914960861206055}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2.1","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9914960861206055}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.2","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.5","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-09"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.35004997253418}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"KP.3.2.4","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.093895435333252}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"internal_f3994b77","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000991","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":142,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":142,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000992","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000993","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":141,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MY.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000995","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":143,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.11924"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7206397516519647"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000997","node_attrs":{"div":137,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":137,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.10"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.12"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.14"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.15","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.15"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.16"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.3","node_attrs":{"div":142,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.4","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.6","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.5","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.7","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5369762101413171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000998","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":140,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000999","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13.1","node_attrs":{"div":140,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}},{"name":"MC.13","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2.1","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}},{"name":"MC.2","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_836f2465","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":142,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.767807722091675}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0001003","node_attrs":{"div":75,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.517561435699463}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":75,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.517561435699463}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001004","node_attrs":{"div":76,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.3251705169677734}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":76,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.3251705169677734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0001005","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.9142704010009766}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.5","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.3","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.7","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0001006","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.1","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-05"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.3","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.71883"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.2","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.4","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0001007","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":82,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"DC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.66094"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"internal_813c","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.69476318359375}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.69476318359375}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.5","node_attrs":{"div":79,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.4","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.6","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.9","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.872365713119507}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"BA.4.1.8"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001009","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001010","node_attrs":{"div":79,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":86,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0001011","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.67074"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5308081831240151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":87,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"CS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5702799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.7561969850799493"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0001012","node_attrs":{"div":83,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.145464897155762}},"branch_attrs":{"mutations":{"nuc":["C1931A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF1a":["Q556K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF1a: Q556K; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.918104648590088}},"branch_attrs":{"mutations":{"nuc":["A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}}},{"name":"BA.5.3.1","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.109306812286377}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"BA.5.3","node_attrs":{"div":83,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.145464897155762}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:72-122"},"partiallyAliased":{"value":"BA.5.3.3"},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.781851291656494}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.5"},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.9","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2392046451568604}},"branch_attrs":{"mutations":{"nuc":["T1570C","A1931C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["K556Q","T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: K556Q, T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"BE.2","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.800013303756714}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T","G28681T"],"N":["E136D"],"ORF1a":["T882I"]},"labels":{"aa":"N: E136D; ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.220089912414551}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","G28681T","C28724T"],"N":["E136D","P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: E136D, P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.109306812286377}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"NODE_0001013","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8083324432373047}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.4","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.250558853149414}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}},{"name":"BA.5.3.2","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.920682430267334}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}}]},{"name":"NODE_0001014","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.902167558670044}},"branch_attrs":{"mutations":{"nuc":["A1931C","A6551C","G29032A"],"ORF1a":["K556Q","M2096L"]},"labels":{"aa":"ORF1a: K556Q, M2096L"}},"children":[{"name":"BA.5.8","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}},{"name":"BA.5.7","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}}]},{"name":"NODE_0001015","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420078754425049}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A","G28681T"],"N":["E136D"],"S":["K444T","N460K"]},"labels":{"aa":"N: E136D; S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6684834957122803}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0001016","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2845587730407715}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","G28681T","T28693C"],"N":["E136D"],"ORF1a":["M85-"]},"labels":{"aa":"N: E136D; ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.6"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.737102031707764}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.7"},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.387746334075928}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001017","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.943603277206421}},"branch_attrs":{"mutations":{"nuc":["A1931C","C21789T"],"ORF1a":["K556Q"],"S":["T76I"]},"labels":{"aa":"ORF1a: K556Q; S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.243032455444336}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"BA.5.5","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.943603277206421}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001018","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891446590423584}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5124127864837646}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0001019","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.720151901245117}},"branch_attrs":{"mutations":{"nuc":["G28681T","T28693C"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BE.12","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0075602531433105}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0001020","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236769199371338}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5231200000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.13"},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.5088823627149919"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.8"},"totalAminoacidDeletions":{"value":94},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":1},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0001021","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T","G28681T"],"N":["E136D"],"ORF1a":["T3308N"]},"labels":{"aa":"N: E136D; ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001022","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281350135803223}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0001023","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001024","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.919694185256958}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0001025","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0001026","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075679063796997}},"branch_attrs":{"mutations":{"nuc":["A1931C","T4906C","C17402T","T18957C","C21077T"],"ORF1a":["K556Q"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1a: K556Q; ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075679063796997}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001027","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130266189575195}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.4","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5883099999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}},{"name":"BA.5.6.3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001028","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001029","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6570799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0001030","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-20"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}}]}]}]}]},{"name":"NODE_0001031","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2636122703552246}},"branch_attrs":{"mutations":{"nuc":["A1T","A1931C","T27438C","C29666T"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.1","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2636122703552246}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.11","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.12","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.42498517036438}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.9656171798706055}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.953991413116455}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.774555206298828}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.263641834259033}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.364013195037842}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.3","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1492865085601807}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.28","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.255985736846924}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.30","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9020943641662598}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.34"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0658464431762695}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.146693468093872}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.6","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.541465997695923}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.4","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.7","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8861465454101562}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.8","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6324868202209473}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0001032","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9345109462738037}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0001034","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213008403778076}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213008403778076}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0001035","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.302816867828369}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198367118835449}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198367118835449}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001038","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.846538543701172}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.846538543701172}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1157443523406982}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.33618688583374}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}},{"name":"DE.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}}]}]},{"name":"NODE_0001041","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4297988414764404}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-28"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001042","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069684028625488}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069684028625488}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806603193283081}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806603193283081}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.106252193450928}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.106252193450928}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001045","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.244868278503418}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.3","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-23"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"DJ.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-10"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0001046","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.52162766456604}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.1.27"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001049","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0001050","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0001051","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7331035137176514}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.082880973815918}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047396659851074}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-15"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.180698871612549}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0001052","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127193450927734}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.532985687255859}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.36","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"NODE_0001053","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024437427520752}},"branch_attrs":{"mutations":{"nuc":["G16935A","G28681T"],"N":["E136D"],"ORF1b":["M1156I"]},"labels":{"aa":"N: E136D; ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024437427520752}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0001054","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.29529333114624}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.29529333114624}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001055","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.49383999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8224959014481948"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0001056","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.3","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"BE.1.4.4","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0001057","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0001058","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708044052124023}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708044052124023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001059","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0001060","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036477565765381}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036477565765381}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45205000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5680790723509552"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.677981853485107}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0001061","node_attrs":{"div":91,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3800950050354004}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":91,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3800950050354004}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3855841159820557}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.436852216720581}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6127800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7257362514460642"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.20","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5446"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8308113969466171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4570536613464355}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6570799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.423999309539795}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.428560256958008}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.4","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.33","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.946379661560059}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.6","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.5","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.459336757659912}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.7","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.914120197296143}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.9","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6576948165893555}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001062","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-26"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0001063","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0001064","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0001065","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001066","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009603500366211}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"NODE_0001067","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710107326507568}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710107326507568}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001068","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"internal_56b3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0001071","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0001073","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6353800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6853534127590314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688453674316406}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2.3","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875691413879395}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"BQ.1.2","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688453674316406}},"branch_attrs":{"mutations":{}}},{"name":"internal_dbfb","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5174000000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6925976779449897"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001078","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":105,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66664"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9874397743924017"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0001079","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-28"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":109,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6059300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:83-122"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"totalAminoacidDeletions":{"value":31},"immune_escape":{"value":"1.0821590912755812"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7586400508880615}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.546395778656006}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.23","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4521584510803223}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.057005405426025}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.637411117553711}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":102,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0001083","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.392918109893799}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-09"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.392918109893799}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.891563892364502}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.535731792449951}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.19","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.225134372711182}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.17","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1496901512146}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.21","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.20","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.5311388969421387}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.25","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7449699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.073443412780762}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5921799999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8728938682420008"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.841209411621094}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8330562114715576}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.36","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.201071739196777}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.314393997192383}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.34","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.40","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.44","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.068432331085205}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.45","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7044315338134766}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.41","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9046695232391357}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.47","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.249931335449219}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.386255741119385}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995408058166504}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.861392974853516}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.56","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530673980712891}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.57","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.360785007476807}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.58","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.378429889678955}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.6","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.975255012512207}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.60","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.916863918304443}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.63","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.371269702911377}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.67","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.056057929992676}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.66","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276078224182129}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.70","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.841140031814575}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.69","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.636171579360962}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.75","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.051732686328446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.239450931549072}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.731176376342773}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.202805519104004}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.202805519104004}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.70602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.662565231323242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0001085","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.960555553436279}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001086","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-19"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-12"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0001087","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.942427635192871}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.780996322631836}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-02"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530292510986328}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0001088","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500977516174316}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ET.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0001090","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ES.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001091","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.74371"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-30"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.994874000549316}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452495098114014}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452495098114014}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918554306030273}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bf35","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.695047378540039}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.695047378540039}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001094","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66913"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9105813557217661"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6774299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001096","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.908818006515503}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.908818006515503}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.810004711151123}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.999442100524902}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0001097","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001098","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0001099","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.548947811126709}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001100","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001101","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0001102","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6486213207244873}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.388934135437012}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.766948223114014}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.134593486785889}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.134593486785889}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478137016296387}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.34834999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.880706782961692"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9221577644348145}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_1117","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504772186279297}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504772186279297}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.8300909996032715}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.499401330947876}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.499401330947876}},"branch_attrs":{"mutations":{}}},{"name":"ED.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1880574226379395}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.897567272186279}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0001106","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.167686462402344}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0001107","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002800464630127}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002800464630127}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.66091775894165}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.224764823913574}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.117682456970215}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302685260772705}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0001111","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.18422269821167}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131554126739502}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.522237777709961}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.840278148651123}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0001113","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.255103588104248}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0001114","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-24"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.3","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"EW.2","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}}]},{"name":"NODE_0001115","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0001116","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":102,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-17"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0001117","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":103,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0001118","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.141738414764404}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.141738414764404}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.071822166442871}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.241168022155762}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001120","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138625144958496}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001122","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0001123","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6995503902435303}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0001124","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-7.3331193923950195}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0001125","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001126","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.1","node_attrs":{"div":104,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"2.05606"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8990816968865659"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.2","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5626099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8771384492554943"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6722600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8744814686582322"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.3","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}}]}]}]}]}]}]}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1467015743255615}},"branch_attrs":{"mutations":{"nuc":["C1627T","A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.11","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.11"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.792257070541382}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001129","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001130","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0001131","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6492786407470703}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6492786407470703}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001132","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6364240646362305}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6364240646362305}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5279"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.933121919631958}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.076331377029419}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"ORF1b":["H1087Y"],"S":["N450D"]},"labels":{"aa":"ORF1b: H1087Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.18","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.087855815887451}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.19","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.17","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.484903812408447}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.2","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4420108795166016}},"branch_attrs":{"mutations":{"nuc":["T6979G","G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.100374221801758}},"branch_attrs":{"mutations":{"nuc":["A396T","T6979G"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.30","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6034899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.35","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"],"S":["N450D"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.36","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8252875804901123}},"branch_attrs":{"mutations":{"nuc":["A761G","T6979G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.4","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5455124378204346}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.914348602294922}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4831809997558594}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"BF.9","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4603519439697266}},"branch_attrs":{"mutations":{"nuc":["G5555A","T6979G","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0001133","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4077556133270264}},"branch_attrs":{"mutations":{"nuc":["T4690C","T6979G","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4077556133270264}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0001134","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.132326364517212}},"branch_attrs":{"mutations":{"nuc":["T6979G","C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.132326364517212}},"branch_attrs":{"mutations":{}}},{"name":"BF.10.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.3218"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.563032084337257"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}}]},{"name":"NODE_0001135","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1162216663360596}},"branch_attrs":{"mutations":{"nuc":["T6979G","C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.380282402038574}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.539719581604004}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0001136","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4314894676208496}},"branch_attrs":{"mutations":{"nuc":["T6979G","C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3808767795562744}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0001137","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.251821517944336}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.251821517944336}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.985884428024292}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.33263"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5959379308450252"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.378326892852783}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.985884428024292}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112126350402832}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112126350402832}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001140","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.462851047515869}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0001141","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.165992736816406}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.292901039123535}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0001142","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.430593729019165}},"branch_attrs":{"mutations":{"nuc":["A3859G","T6979G"]}},"children":[{"name":"BF.16","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36989164352417}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.13","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.22","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5231502056121826}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.734994888305664}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.34"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6532351970672607}},"branch_attrs":{"mutations":{"nuc":["T6979G","G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.735113620758057}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.314535617828369}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.314535617828369}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.48889999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2785773277282715}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0001145","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.552170276641846}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6700541973114014}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0001146","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160181045532227}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160181045532227}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001147","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.755500316619873}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0001148","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.070246458053589}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.266221046447754}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001149","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.60558819770813}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0001150","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.3","node_attrs":{"div":116,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-08"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}},{"name":"BF.5.2","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.603853225708008}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"BA.5.2.1.42"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.39715313911438}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257153511047363}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416705131530762}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2871978282928467}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238437175750732}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238437175750732}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.085692405700684}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0001154","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.84029483795166}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.84029483795166}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-05"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.12","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.11","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.15","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6393200000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.23","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.21","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.24","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.26","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.6","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.8","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.7","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.9","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0001155","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001156","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0001157","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001158","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.2","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}}]},{"name":"NODE_0001159","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0001160","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3122615814208984}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0001161","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0001162","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-25"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.4","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.7","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"BF.7.14.5","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"NODE_0001163","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.3","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.2","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.6","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0001164","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6319823265075684}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8151323795318604}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.182566165924072}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9923171997070312}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0001165","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-1.9059104919433594}},"branch_attrs":{"mutations":{"nuc":["C16616A","C27012T","C27513T"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3895606994628906}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6929638385772705}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7767930030822754}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.22","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4965717792510986}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.28","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1461098194122314}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.30","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523481845855713}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.29","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.456769943237305}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.34","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.34"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.511476755142212}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.394333839416504}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.42"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.44","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.44"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278106212615967}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.43","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5642800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.43"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5413273873731987"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.46","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.46"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.212985038757324}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.45","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5131699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.45"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998797416687012}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.54","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.54"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.171896934509277}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.52","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.52"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112395763397217}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.55"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.987527847290039}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.53","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.53"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.224037170410156}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.57","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.57"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.694659471511841}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.58","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.58"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236799716949463}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.61","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.61"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.711515426635742}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.63","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.63"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-14"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.59","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.59"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1926188468933105}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.5.2.62","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.62"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162878036499023}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.8","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9392523765563965}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.285115718841553}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.365017890930176}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782564401626587}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782564401626587}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796359539031982}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"NODE_0001168","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3798828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"internal_1651","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162424087524414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162424087524414}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4564899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7208595659836455"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.671617031097412}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.313830852508545}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.56458"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.30660604695253"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.313830852508545}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.4733147621154785}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001171","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.635266304016113}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.56"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.025681972503662}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0001173","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0985677242279053}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0985677242279053}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.277458667755127}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"internal_d5b0","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4673573970794678}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4673573970794678}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{}}},{"name":"BZ.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}},{"name":"BZ.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_74ef","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.5325236320495605}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5594199999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3253063676642168"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0001177","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]},{"name":"NODE_0001178","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.059089183807373}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.51","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.51"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.50","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.50"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-21"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.72301721572876}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.60","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.60"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0001179","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{}}},{"name":"CY.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.678462505340576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}},{"name":"CY.2","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}}]},{"name":"NODE_0001180","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.246817111968994}},"branch_attrs":{"mutations":{"nuc":["T27012C","T27513C"]}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.743002891540527}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.62591552734375}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0001181","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8558647632598877}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8558647632598877}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]}]},{"name":"NODE_0001182","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.204470634460449}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-25"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.356487274169922}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DB.3","node_attrs":{"div":107,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}}]},{"name":"NODE_0001185","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.905637264251709}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"internal_f379","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.66318941116333}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.66318941116333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001187","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36233377456665}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}},{"name":"CR.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0001188","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7050411701202393}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0001189","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8912155628204346}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]},{"name":"NODE_0001190","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}},{"name":"DY.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_7385","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.201568603515625}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.201568603515625}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.38661"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.82891845703125}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.4","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.628321170806885}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6942999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.5295255377787571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.5","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.973639488220215}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-02"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.6","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.885843276977539}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"internal_7ebe","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}}]},{"name":"NODE_0001193","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.384389877319336}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.319447994232178}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}},{"name":"CP.1.3","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6003199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"NODE_0001194","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047609329223633}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047609329223633}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.240954875946045}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.374807834625244}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.374807834625244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001197","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0001198","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.068063735961914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.068063735961914}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0001199","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.98232364654541}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.71883"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998134136199951}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.711119651794434}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0001200","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.607345104217529}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0001201","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-29"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.657632350921631}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json.bak b/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json.bak new file mode 100644 index 00000000..de441105 --- /dev/null +++ b/data/nextstrain/sars-cov-2/wuhan-hu-1/orfs/tree.json.bak @@ -0,0 +1 @@ +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-21","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF1a":{"end":13468,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"ORF1b":{"end":21555,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":13468,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/wuhan/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-02-18","#531EA6"],["2021-02-21","#521EA7"],["2021-03-02","#4E20AC"],["2021-03-10","#4C24AF"],["2021-03-15","#4B26B1"],["2021-04-01","#472DB8"],["2021-04-07","#462FBA"],["2021-04-08","#4530BB"],["2021-04-13","#4432BD"],["2021-04-19","#4334BF"],["2021-04-20","#4335C0"],["2021-04-21","#4235C0"],["2021-04-23","#4236C1"],["2021-04-26","#4137C2"],["2021-04-30","#4039C4"],["2021-05-05","#403BC5"],["2021-05-13","#4040C6"],["2021-05-16","#4041C7"],["2021-05-21","#3F44C8"],["2021-05-25","#3F46C8"],["2021-05-26","#3F46C9"],["2021-06-04","#3F4BCA"],["2021-06-14","#3F50CC"],["2021-06-18","#3F53CD"],["2021-06-19","#3F53CD"],["2021-06-25","#3F56CE"],["2021-06-30","#3E59CF"],["2021-07-01","#3E59CF"],["2021-07-13","#3F5FD0"],["2021-07-22","#4064CF"],["2021-07-23","#4064CF"],["2021-07-26","#4066CF"],["2021-07-27","#4066CF"],["2021-07-28","#4067CF"],["2021-07-30","#4068CF"],["2021-08-02","#4169CF"],["2021-08-03","#416ACF"],["2021-08-04","#416ACF"],["2021-08-07","#416CCE"],["2021-08-09","#416DCE"],["2021-08-10","#416DCE"],["2021-08-12","#416ECE"],["2021-08-13","#416FCE"],["2021-08-16","#4270CE"],["2021-08-17","#4271CE"],["2021-08-18","#4271CE"],["2021-08-19","#4271CE"],["2021-08-22","#4273CE"],["2021-08-25","#4374CD"],["2021-08-27","#4375CD"],["2021-09-02","#4378CD"],["2021-09-03","#4379CD"],["2021-09-13","#447DCC"],["2021-09-20","#4580CA"],["2021-09-23","#4681C9"],["2021-09-24","#4682C9"],["2021-09-27","#4783C8"],["2021-09-29","#4783C8"],["2021-09-30","#4784C8"],["2021-10-04","#4885C7"],["2021-10-08","#4887C6"],["2021-10-11","#4988C5"],["2021-10-12","#4988C5"],["2021-10-18","#4A8BC3"],["2021-10-22","#4A8CC2"],["2021-10-25","#4B8DC2"],["2021-10-27","#4B8EC1"],["2021-10-28","#4B8FC1"],["2021-11-02","#4C91C0"],["2021-11-04","#4C91BF"],["2021-11-05","#4D92BF"],["2021-11-17","#4F96BC"],["2021-11-18","#4F96BB"],["2021-11-19","#4F97BB"],["2021-11-23","#5098BA"],["2021-11-24","#5098B9"],["2021-11-25","#5098B9"],["2021-11-29","#5199B7"],["2021-12-03","#529AB6"],["2021-12-07","#539BB4"],["2021-12-08","#539CB4"],["2021-12-10","#539CB3"],["2021-12-13","#549DB2"],["2021-12-14","#549DB2"],["2021-12-17","#559EB1"],["2021-12-19","#559FB0"],["2021-12-21","#569FAF"],["2021-12-22","#56A0AF"],["2021-12-26","#57A1AE"],["2021-12-28","#57A1AD"],["2022-01-01","#58A2AB"],["2022-01-05","#59A3AA"],["2022-01-07","#59A4A9"],["2022-02-16","#63AC99"],["2022-02-23","#65AD96"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-29","#6FB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-21","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Beta","#4067CF"],["Gamma","#4A8BC3"],["Delta","#5AA4A9"],["Epsilon","#6FB488"],["Eta","#8BBB69"],["Theta","#A9BD53"],["Iota","#C7B944"],["Kappa","#DDA93C"],["Lambda","#E68A35"],["Mu","#E35C2C"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","clade_who","clade_display","designation_date","designation_recency"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":true},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":false},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{},"labels":{"clade":"19A"}},"children":[{"name":"B","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":0},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{"ORF6":["D61L"],"S":["T19I"]},"labels":{"aa":"ORF6: D61L; S: T19I","spike_mutations":"T19I"}},"children":[{"name":"XAA","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAA"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A1610G","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C8247T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12445T","C12880T","C14408T","C15714T","C17410T","A18163G","A19356G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["N449D","K856R","S2083-","L2084I","S2661F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: N449D, K856R, S2083-, L2084I, S2661F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XA","node_attrs":{"div":33,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XA"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-05"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T445C","T2019C","C3037T","C4999T","C6286T","C8090T","C9430T","A10323G","C13945T","C14408T","G20410A","G21255C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23208T","C23271A","A23403G","C23604A","C23709T","T24506G","G24914C","G25855T","C27972T","G28048T","A28095T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"N":["D3L","R203K","G204R","S235F"],"ORF1a":["M585T","L2609F","K3353R"],"ORF1b":["P160S","P314L","E2315K"],"ORF3a":["D155Y"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","K68*","Y73C"],"S":["I19T","H69-","V70-","Y144-","N501Y","T549I","A570D","D614G","P681H","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, R203K, G204R, S235F; ORF1a: M585T, L2609F, K3353R; ORF1b: P160S, P314L, E2315K; ORF3a: D155Y; ORF6: L61D; ORF8: Q27*, R52I, K68*, Y73C; S: I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H","spike_mutations":"I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H"}}},{"name":"XAC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAC"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.851975917816162}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15720T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25731T","C25810T","C26028T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","A2909V","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["L140F"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, A2909V, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: L140F; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAB","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.443575382232666}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17010T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAF","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-","T3750I","V3751F"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-, T3750I, V3751F; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAG","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.28093999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C2857T","C3037T","T5386G","C5585A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C12880T","C14408T","C15714T","C17410T","C17502T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","L1774I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, L1774I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAD","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAD"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.857146263122559}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","A1250G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T329A","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T329A, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAE","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.17270999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAE"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","G4975A","A6390C","C9344T","A9424G","C9534T","C9803T","C9866T","C10029T","C10198T","G10447A","C10449A","C11249T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C","T29748C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","E2042A","L3027F","T3090I","L3201F","T3255I","P3395H","R3662C","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, E2042A, L3027F, T3090I, L3201F, T3255I, P3395H, R3662C, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAL","node_attrs":{"div":61,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","A2865G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","G21586T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","E867G","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L8F","L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, E867G, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K","spike_mutations":"L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K"}}},{"name":"XAK","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.15166"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAK"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.3037714005953052"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4927T","T5386G","C7834T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C12880T","C14408T","C15240T","A18163G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","A22001G","T22200G","G22578A","G22599A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22942G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24863T","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","I1566V"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","H69-","V70-","G142D","K147E","V213G","G339D","R346K","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N460K","S477N","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","H1101Y"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, I1566V; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y","spike_mutations":"I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y"}}},{"name":"XAJ","node_attrs":{"div":72,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAJ"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.647030830383301}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11674T","C12880T","C14408T","T15009C","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","A23535G","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N658S","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XAH","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAH"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.713448524475098}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","G17242T","C17410T","A18163G","C18246T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33G","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","A1259S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33G, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, A1259S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAM","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.75567"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAM"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T3750I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T3750I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAP","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAP"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-30"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9286975860595703}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C5407A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAR","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.44734525680542}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21796T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","R78S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAN","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAN"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.080811023712158}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7973A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","C17822T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","T27696C","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29666T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L2570M","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","P1452L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L2570M, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, P1452L, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAQ","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","C9857T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23779T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAT","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","C10277T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19317T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25810T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","A2909V","L3027F","T3090I","L3201F","T3255I","L3338F","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["L140F","T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, A2909V, L3027F, T3090I, L3201F, T3255I, L3338F, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: L140F, T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAV","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAV"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.706950664520264}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C6606T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15960T","G17278T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","S2114F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","V1271L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, S2114F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, V1271L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAU","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAU"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.173168659210205}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","T17407C","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAS","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAS"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.466667652130127}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAW","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.91409"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAW"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.274687314409391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C335T","G569A","T689C","G1048T","G1125A","C1973T","C3037T","G3246A","G4181T","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9676C","C10029T","A10323G","A11201G","G11330A","A11332G","C11866T","C13806T","C13994T","C14408T","C14585T","G15451A","C16466T","C17304T","C17550T","A17973G","G18525A","C19220T","C19290T","C20402T","G20493A","C21575T","C21618G","C21636T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","T22942A","G22992A","C22995A","A23013C","T23042C","A23055G","A23063T","T23075C","C23114T","A23403G","C23525T","C23604A","C23854A","G23948T","G24145A","A24424T","T24469A","C25000T","C25584T","A25592G","C26060T","C26270T","C26537T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28562A","G28646A","C28849T","C28873T","G28881T","G28916T","G29402T","C29635T","G29742T"],"E":["T9I"],"M":["Q19E","A63T"],"N":["D63G","G97S","A125T","R203M","G215C","D377Y"],"ORF1a":["R24C","E102K","S142P","K261N","R287K","S994N","A1306S","P1596L","D1962N","P2046L","P2287S","A2388T","V2930L","T3255I","K3353R","T3646A","V3689M"],"ORF1b":["A176V","P314L","A373V","G662S","P1000L","A1918V","S2312L"],"ORF3a":["K67R","T223I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["L5F","I19R","P25L","E156-","F157-","R158G","N211-","L212I","L242-","A243-","G339D","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","N460K","S477N","T478K","E484A","S494P","Q498R","N501Y","Y505H","D614G","H655Y","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: D63G, G97S, A125T, R203M, G215C, D377Y; ORF1a: R24C, E102K, S142P, K261N, R287K, S994N, A1306S, P1596L, D1962N, P2046L, P2287S, A2388T, V2930L, T3255I, K3353R, T3646A, V3689M; ORF1b: A176V, P314L, A373V, G662S, P1000L, A1918V, S2312L; ORF3a: K67R, T223I; ORF8: D119-, F120-; ORF9b: T60A; S: L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAZ","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAZ"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1912T","C2232T","C2790T","C3037T","C3317T","T3358C","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A656V","T842I","P1018S","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A656V, T842I, P1018S, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XB","node_attrs":{"div":29,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"XB"},"totalAminoacidDeletions":{"value":5},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-18"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.699341297149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C3688T","C3884T","C6633T","A7142G","A9614G","C9693T","A9754C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14408T","G15451A","C16466T","C21057T","T21615G","C21846T","A22036C","A23403G","C23604A","C23625T","T23765G","C24442T","C24642T","G26158-","T26159-","T26160-","A26161-","C26222T","C27389T","C27769T","G28048A","A28271-","A28330G","C28854T","A28910T"],"N":["S194L","N213Y"],"ORF1a":["P1207S","A2123V","S2293G","T3117A","A3143V","R3163S","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","P1000L"],"ORF3a":["V256-","N257-","P258I","M260I","E261I","P262I","T269I","P274I","L275I"],"ORF6":["L61D"],"ORF7b":["S5L"],"ORF8":["R52K"],"ORF9b":["D16G"],"S":["L18R","I19T","T95I","R158S","D614G","P681H","A688V","S735A","T1027I"]},"labels":{"aa":"N: S194L, N213Y; ORF1a: P1207S, A2123V, S2293G, T3117A, A3143V, R3163S, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, P1000L; ORF3a: V256-, N257-, P258I, M260I, E261I, P262I, T269I, P274I, L275I; ORF6: L61D; ORF7b: S5L; ORF8: R52K; ORF9b: D16G; S: L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I","spike_mutations":"L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I"}}},{"name":"XBA","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20215999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBA"},"totalAminoacidDeletions":{"value":4},"immune_escape":{"value":"0.29808642936638835"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4181T","C6402T","C7124T","C8595T","C8986T","G9053T","C10029T","A11201G","A11332G","G13812T","C14408T","C14790T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","A22991G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","T26767C","G26959A","T27638C","A27663T","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","C28311T","A28461G","G28881A","G28882A","G28883C","G29402T","G29742T"],"M":["I82T","R146H"],"N":["P13L","D63G","R203K","G204R","D377Y"],"ORF1a":["S135R","T842I","A1306S","P2046L","P2287S","T2777I","V2930L","T3255I","T3646A"],"ORF1b":["M115I","P314L","A520V","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["P10S","T60A"],"S":["L18F","I19R","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477D","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","T1117I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, D63G, R203K, G204R, D377Y; ORF1a: S135R, T842I, A1306S, P2046L, P2287S, T2777I, V2930L, T3255I, T3646A; ORF1b: M115I, P314L, A520V, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: P10S, T60A; S: L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I","spike_mutations":"L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I"}}},{"name":"XBD","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBD"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBE","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBE"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.568920612335205}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27800T","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","T1050N","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, T1050N, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBH","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.37244999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBH"},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-16"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7528T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13730T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25157A","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28881A","G28882A","G28883C","A29510C","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","T29758C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["A88V","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","D1199N"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: A88V, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N"}}},{"name":"XBG","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBG"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10116T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11665T","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","A24676G","C25000T","C25584T","C26060T","T26180C","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","T3284I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I","I263T"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, T3284I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I, I263T; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBM","node_attrs":{"div":74,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBM"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","G19891A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23202T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27549T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","D2142N","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","T547I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, D2142N, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBN","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.40686999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBN"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","A2863G","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","A19459G","C19554T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C25638T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","I1998V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, I1998V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBP","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBP"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7303T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C12952T","C13965T","C14408T","C15277T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","T23773C","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","H604Y","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, H604Y, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBQ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBQ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G14829T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","M454I","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, M454I, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBR","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1093T","G1440A","A1964G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","A5844G","C8597T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21077T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22855T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25471C","C25553T","T25569C","C25584T","G26031A","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","G392D","I567V","T842I","S1221L","G1307S","P1640S","K1860R","L2778F","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I","T2537I"],"ORF3a":["D27H","A54V","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, G392D, I567V, T842I, S1221L, G1307S, P1640S, K1860R, L2778F, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I, T2537I; ORF3a: D27H, A54V, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBU","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBU"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","A3620V","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, A3620V, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBS","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBS"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T670G","C2790T","C2842T","C3037T","C3796T","C3809T","C3927T","G4184A","C4321T","C4586T","C5183T","C6982T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","T20748C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["G82-","H83-","V84-","M85V","S135R","T842I","L1182F","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: G82-, H83-, V84-, M85V, S135R, T842I, L1182F, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBT","node_attrs":{"div":81,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.64255"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5037920175803539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C829T","C1627T","C2790T","C3037T","A3207G","G4184A","G4288A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","G23587A","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","D981G","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, D981G, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBV","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32919999999999994"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBV"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8040G","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","G15957T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123A","A23223G","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24170G","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","D2592G","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","T1050N","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","P521T","E554G","D614G","H655Y","N679K","P681H","N764K","D796Y","I870V","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, D2592G, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, T1050N, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K"}}},{"name":"XBW","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBW"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22612C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","G29260A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBY","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBY"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5812T","C9344T","A9424G","C9532T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","G19962T","A20055G","C21054T","G21305A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T28137A","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I","R2613H"],"ORF3a":["T223I"],"ORF8":["S82T"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I, R2613H; ORF3a: T223I; ORF8: S82T; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBZ","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBZ"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","T2954C","C3037T","G4184A","C4321T","C6040T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","C12880T","T14257C","C14408T","C15714T","G16935A","A17039G","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T21992-","A21993-","T21994-","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22858T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23086T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26428T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","C28770T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","V62F"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","T166I","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["Y264H","P314L","M1156I","N1191S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","Y144-","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, V62F; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, T166I, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: Y264H, P314L, M1156I, N1191S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XC","node_attrs":{"div":39,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XC"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5239T","T5514C","C6402T","C7124T","C8986T","G9053T","C10029T","A11201G","A11332G","C14408T","G15451A","C16466T","C19220T","C21618G","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22081T","T22917G","C22995A","A23403G","C23604G","G24410A","C25469T","T26767C","G27390T","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"M":["I82T"],"N":["D3L","R203K","G204R","S235F"],"ORF1a":["A1306S","V1750A","P2046L","P2287S","V2930L","T3255I","T3646A"],"ORF1b":["P314L","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","Y73C"],"S":["I19R","T95I","G142D","E156-","F157-","R158G","Q173H","L452R","T478K","D614G","P681R","D950N"]},"labels":{"aa":"M: I82T; N: D3L, R203K, G204R, S235F; ORF1a: A1306S, V1750A, P2046L, P2287S, V2930L, T3255I, T3646A; ORF1b: P314L, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF8: Q27*, R52I, Y73C; S: I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N","spike_mutations":"I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N"}}},{"name":"XCC","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCC"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1545T","C2790T","C3037T","C3796T","C3857A","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A427V","T842I","Q1198K","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A427V, T842I, Q1198K, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCA","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.74825"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCA"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2062T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C5748A","C9344T","A9424G","T9454C","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19017T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21893A","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","C22747T","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","C23595T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","T25975C","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","T1828N","L3027F","T3090I","L3201F","T3255I","P3395H","A3620V","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["S195P","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","D111N","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","T678I","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, T1828N, L3027F, T3090I, L3201F, T3255I, P3395H, A3620V, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: S195P, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCB","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.41968"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCB"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","A11126G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C12880T","C14408T","C14724T","C15714T","C17410T","A18163G","G18651A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22302-","T22303-","T22304-","T22348A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27600T","C27807T","C27889T","A28271T","T28282C","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","M3621V","S3675-","G3676-","F3677-","A4016T"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","S247-","Y248N","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, M3621V, S3675-, G3676-, F3677-, A4016T; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCE","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1931A","C2790T","T2954C","C3037T","G4184A","C4321T","C9344T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15810T","T15939C","T16342C","C17410T","T17859C","A18163G","G18811A","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","Q556K","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","D1782N","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","Y200C","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, Q556K, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, D1782N, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCD","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.95377"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCD"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-08"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18006C","A18163G","A19173G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22203A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","G28077T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28681T","G28881A","G28882A","G28883C","C29367T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","P365L","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","R214H","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, P365L, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF8: V62L; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCG","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.16254"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8170G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCJ","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCJ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C1063T","C2790T","C3037T","G4184A","C4321T","C6312T","A6616G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22843C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27431T","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28770T","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","T166I","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","T2016I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["A13V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","G181R","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, T166I, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, T2016I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: A13V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCK","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCK"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","T2128C","C2790T","C3037T","G3242A","G4184A","C4321T","C5512T","G5720A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12880T","C12970T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18096C","A18163G","A19326G","C19955T","G19962T","A20055G","G20060T","A21137G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","C26270T","G26529A","C26577G","G26709A","G26951C","C27807T","C27889T","C28163A","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","T29726-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G993S","G1307S","G1819S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I","S2198I","K2557R"],"ORF3a":["T223I","V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G993S, G1307S, G1819S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I, S2198I, K2557R; ORF3a: T223I, V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XCL","node_attrs":{"div":101,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.89509"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C7417T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15755G","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23093A","A23403G","C23525T","T23599G","C23604A","C23741T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25046T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S763C","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","V511I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","P1162S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S763C, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S"}}},{"name":"XCN","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18525999999999987"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCN"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C337T","T670G","C1142T","C1471T","C1513T","C1686T","T2372C","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7318T","C8782T","G8849A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C14408T","C14790T","T14961C","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21807A","C21910T","G21987A","A22001G","T22016C","C22033A","A22121G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","T23332C","A23403G","C23453T","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27635T","C27807T","G27915T","C28253T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","L293F","A474V","T842I","S1221L","G1307S","P1640S","V2862M","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","P82H","G142D","K147E","W152R","F157L","K187E","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","P631S","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, L293F, A474V, T842I, S1221L, G1307S, P1640S, V2862M, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: S81L; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCM","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","G331T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","C5730T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T13560C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17661C","T17859C","A18163G","A18879G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24134A","A24373G","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","A29558G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["Q22H","K47R","S135R","T842I","G1307S","T1822I","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["A72T","A110V","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","F157L","N185D","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: Q22H, K47R, S135R, T842I, G1307S, T1822I, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: A72T, A110V, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}}},{"name":"XCP","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCP"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","C3622T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","C12880T","C14408T","A14634G","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","C19185T","A19326G","C19488T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","I3758V","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, I3758V, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCQ","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","A13187G","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","A22320G","C22388T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23757T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","I4308V"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","T732I","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, I4308V; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K"}}},{"name":"XCR","node_attrs":{"div":106,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCR"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C13405T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24373C","A24424T","T24469A","C25000T","A25359G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26708G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K","K1266R"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R"}}},{"name":"XCS","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCS"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17010T","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27669G","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","A29221G","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K"}}},{"name":"XCU","node_attrs":{"div":99,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.8835"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCU"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1437T","C2790T","C3037T","T3478C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","C9891T","C10029T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","A17207G","A19890G","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","T23042C","A23055G","A23063T","T23075C","C23123A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","C26606T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28376A","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","A35T","R203K","G204R","S413R"],"ORF1a":["S135R","S391F","T842I","T1543I","P1640L","S2104I","G2265S","V2276I","I2501V","A3209V","T3255I","V3718A","T3750I"],"ORF1b":["P314L","G662S","P1000L","T1050I","Y1247C"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","D215H","A222V","L242-","A243-","S256L","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","S494P","Q498R","N501Y","Y505H","P521T","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, A35T, R203K, G204R, S413R; ORF1a: S135R, S391F, T842I, T1543I, P1640L, S2104I, G2265S, V2276I, I2501V, A3209V, T3255I, V3718A, T3750I; ORF1b: P314L, G662S, P1000L, T1050I, Y1247C; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCV","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCV"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","T5422C","C7044A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27065A","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28182G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","P2260H","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, P2260H, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, S97G; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCY","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.0860600000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCY"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCW","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.9577000000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCW"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","T6394C","G6536A","G8863T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T14305C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","G18636A","T18882C","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27513T","C27684T","C27807T","G27915T","T28034C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","G2091S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["Y280H","P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","I210-","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, G2091S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: Y280H, P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCZ","node_attrs":{"div":112,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCZ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","A15436G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22609G","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26735T","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28519T","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","M657V","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-","T79I"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, M657V, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-, T79I; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XD","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.029110000000000004"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XD"},"totalAminoacidDeletions":{"value":5},"immune_escape":{"value":"0.17203353628663032"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","A1321C","C3037T","G4181T","C6402T","C7124T","C7851T","A8723G","C8986T","G9053T","C10029T","A11201G","A11332G","C14407T","C14408T","T15264C","G15451A","C16466T","C19220T","C21618G","G21641T","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25667T","G25855T","T26767C","T27638C","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G28916T","G29402T","G29540A","G29645T","G29742T"],"M":["I82T"],"N":["D63G","R203M","G215C","D377Y"],"ORF1a":["E352D","A1306S","P2046L","P2287S","A2529V","I2820V","V2930L","T3255I","T3646A"],"ORF1b":["P314F","G662S","P1000L","A1918V"],"ORF3a":["S92L","D155Y"],"ORF6":["L61D"],"ORF7a":["V82A","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["I19R","A27S","T95I","G142D","E156-","F157-","R158G","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"M: I82T; N: D63G, R203M, G215C, D377Y; ORF1a: E352D, A1306S, P2046L, P2287S, A2529V, I2820V, V2930L, T3255I, T3646A; ORF1b: P314F, G662S, P1000L, A1918V; ORF3a: S92L, D155Y; ORF6: L61D; ORF7a: V82A, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: T60A; S: I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XDB","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.8657900000000001"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","G15982A","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["P314L","G662S","V839I","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: P314L, G662S, V839I, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDC","node_attrs":{"div":108,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDC"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2110T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","C15763T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21036T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDE","node_attrs":{"div":104,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.42535999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","T21363C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26612G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29535T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","S302F","T842I","G1307S","P2079Q","T2283I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","P4220L"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, S302F, T842I, G1307S, P2079Q, T2283I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, P4220L; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDF","node_attrs":{"div":107,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C335T","A405G","T670G","C2790T","C3037T","T3453C","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","G27666T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","T28382C","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","S37P","R203K","G204R","S413R"],"ORF1a":["R24C","K47R","S135R","T842I","V1063A","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, S37P, R203K, G204R, S413R; ORF1a: R24C, K47R, S135R, T842I, V1063A, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7a: E91D; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDG","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDG"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C547T","T670G","C1758T","C2790T","C3037T","G4184A","C4321T","T4579A","T4690C","T4930C","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","T16905C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","A23598G","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","A25744G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28754T","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","L161F","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A498V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["I118V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679R","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, L161F, R203K, G204R, S413R; ORF1a: K47R, S135R, A498V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: I118V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDH","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.00936"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDH"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","T2992A","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","T4744C","C5183T","T7477C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C13335T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","D909E","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S","A4357V"],"ORF1b":["P314L","G662S","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, D909E, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S, A4357V; ORF1b: P314L, G662S, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDJ","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDJ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C8947T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","A10861G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G29081T","A29510C","C29625T","A29700G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","V270L","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","F157L","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, V270L, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDL","node_attrs":{"div":110,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2650T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","C17410T","T17859C","C17976T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","T24903C","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","C28253A","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["D54N","P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","F120L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","I1114T"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: D54N, P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, F120L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T"}}},{"name":"XDM","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.1446900000000002"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","T24046C","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","D335G","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["T76A","P314L","G662S","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, D335G, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: T76A, P314L, G662S, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDN","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDN"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","C280T","T670G","C897A","C1762A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","C12880T","T13339C","C14408T","C14425T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","F499L","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, F499L, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K"}}},{"name":"XDS","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDS"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","G598A","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29409T","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","C29836T"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","T379I","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, T379I, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDT","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDT"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C1601T","C2790T","C3037T","G3431T","G4184A","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9344T","A9424G","C9534T","C9661T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","T25496C","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27014A","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29778A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","L446F","T842I","V1056L","G1307S","N2526S","A2710T","I2790V","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","V3892A","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["I35T","T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","H69-","V70-","V127F","G142D","Y144-","R158G","N211-","L212I","V213G","L216F","A222V","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, L446F, T842I, V1056L, G1307S, N2526S, A2710T, I2790V, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, V3892A, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: I35T, T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}}},{"name":"XDU","node_attrs":{"div":111,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.63761"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDU"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.9475349114594978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","C3177T","C3587T","C3944A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","C22674T","T22679C","C22686T","A22688G","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26078T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","P971L","H1108Y","Q1227K","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I","T229I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","S371F","S373P","S375F","T376A","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, P971L, H1108Y, Q1227K, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I, T229I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDW","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.15919"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDW"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","T1030C","A2127G","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14120T","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21301T","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","Y621C","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P218L","P314L","R1315C","I1566V","T2163I","P2612S"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A263V","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, Y621C, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P218L, P314L, R1315C, I1566V, T2163I, P2612S; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XDZ","node_attrs":{"div":114,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDZ"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7086T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","C23557T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","T2274I","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, T2274I, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDY","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDY"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","G19669A","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","C22858T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","G2068R","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, G2068R, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XE","node_attrs":{"div":62,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XE"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XE"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C14599T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XEA","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.41162"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEA"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2268340125514634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","C13255T","T13339C","A13712G","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","D1513E","K1973R","N2526S","A2529S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["K82R","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, D1513E, K1973R, N2526S, A2529S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: K82R, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEB","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEB"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XED","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XED"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":17.361},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XED"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9430T","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","A13308G","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25350T","C25584T","C26060T","C26270T","G26529C","C26577G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","T170I","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I","K4348R"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L","P1263L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, T170I, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I, K4348R; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L"}}},{"name":"XEG","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEG"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":950.694},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEG"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","A2443G","C2790T","C2939T","C3037T","C3876T","G4184A","C4234T","C4321T","G6536A","A6646G","T6747C","C7819G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T10723C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","G19327T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","C23191T","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","P892S","A1204V","G1307S","G2091S","L2161S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","A1954S","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, P892S, A1204V, G1307S, G2091S, L2161S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, A1954S, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEE","node_attrs":{"div":125,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEE"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEE"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.013909339904785}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","G17334T","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","T2121A","T2283I","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","H146Q","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, T2121A, T2283I, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XEF","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEF"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":34.028},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.12538"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEF"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7268345560655398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","G4255T","C4321T","C4683T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","A1473V","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","N211-","L212I","V213G","L216F","H245N","A264D","I332V","L335S","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, A1473V, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XG","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XG"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XG"},"totalAminoacidDeletions":{"value":9},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","T5386G","C5672T","G5924A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19855G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","P1803S","V1887I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","I2130V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, P1803S, V1887I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, I2130V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XH","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XH"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.385257720947266}},"branch_attrs":{"mutations":{"nuc":["C241T","T902C","C904A","G1244A","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28435T","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["C213R","G327S","K856R","S2083-","L2084I","A2710T","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-","P51L"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: C213R, G327S, K856R, S2083-, L2084I, A2710T, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-, P51L; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XF","node_attrs":{"div":57,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XF"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.623017311096191}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","T1390C","A2255G","C3037T","G4181T","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29632T"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["I664V","A1306S","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: I664V, A1306S, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XJ","node_attrs":{"div":65,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XJ"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","G11287-","T11288-","C11289-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675F","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675F, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XK","node_attrs":{"div":59,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-3.62446"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XK"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":45},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A16064G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23403G","C23525T","T23599G","C23604A","A23767G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","R1628C","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","Q866R","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, R1628C, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, Q866R, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XL","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C241T","C875T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G14229A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["L204F","K856R","V1887I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: L204F, K856R, V1887I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XM","node_attrs":{"div":60,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XM"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XM"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-31"},"totalAminoacidSubstitutions":{"value":46},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.202030658721924}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XN","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XN"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XN"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.321341514587402}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","G10986A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","R3574K","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, R3574K, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XP","node_attrs":{"div":59,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.023200000000000068"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XP"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3616394203564539"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.596989154815674}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24190C","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","C26880A","A27259C","C27807T","A28254-","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3G","Q19E","A63T","L120I"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF8":["I121-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T, L120I; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF8: I121-; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XQ","node_attrs":{"div":66,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XQ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.557485103607178}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A17615G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","K1383R","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, K1383R, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XR","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XR"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C4893T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G13295A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25524G","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","C27131T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","T1543I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","D4344N"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, T1543I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, D4344N; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XS","node_attrs":{"div":61,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XS"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XS"},"totalAminoacidDeletions":{"value":14},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.812867641448975}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5365T","C6196T","C6402T","C7124T","C8986T","G9053T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21595T","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["A1306S","P2046L","P2287S","V2930L","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","I1566V"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: A1306S, P2046L, P2287S, V2930L, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, I1566V; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XU","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XU"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XU"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.814977169036865}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C16887T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","V1887I","S2083-","L2084I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, V1887I, S2083-, L2084I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XT","node_attrs":{"div":63,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.945826530456543}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13994T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21786T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["A176V","P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G75V","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: A176V, P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XV","node_attrs":{"div":62,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XV"},"totalAminoacidDeletions":{"value":10},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.5818281173706055}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3583T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XW","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XW"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XW"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-12"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","C10507T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12756T","C12880T","C14408T","C15714T","G16020T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","G1307S","L3027F","T3090I","T3255I","P3395H","S3675-","G3676-","F3677-","T4164I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, G1307S, L3027F, T3090I, T3255I, P3395H, S3675-, G3676-, F3677-, T4164I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XY","node_attrs":{"div":68,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XY"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A1585G","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11049C","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","A22351G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26058T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K856R","S2083-","L2084I","A2710T","T3255I","P3395H","V3595A","L3674-","S3675-","G3676-","I3758V"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K856R, S2083-, L2084I, A2710T, T3255I, P3395H, V3595A, L3674-, S3675-, G3676-, I3758V; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XZ","node_attrs":{"div":64,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XZ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XZ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.045060634613037}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","G20398A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF1a":["S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","R1315C","I1566V","T2163I","E2311K"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF1a: S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, R1315C, I1566V, T2163I, E2311K; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"internal_XBK","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBK.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBK"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","A1124G","C1973T","A2163C","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16856G","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","G25947C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27741T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R287G","E633A","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","A4068S"],"ORF1b":["P314L","G662S","S959P","D1130G","R1315C","I1566V","T2163I"],"ORF3a":["Q185H","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R287G, E633A, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, A4068S; ORF1b: P314L, G662S, S959P, D1130G, R1315C, I1566V, T2163I; ORF3a: Q185H, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCH.1","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCH"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.36673000000000006"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCH"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1684T","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7051T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19886G","C19955T","A20055G","C20320T","A20741G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22115G","A22190G","T22200G","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","T24073C","C24134A","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","R542C","A690V","T842I","G1307S","G1819S","L3027F","T3090I","A3143V","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","K2140R","T2163I","H2285Y","Q2425R"],"ORF3a":["A72T","A110V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","N185D","I210V","V213G","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, R542C, A690V, T842I, G1307S, G1819S, L3027F, T3090I, A3143V, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, G662S, S959P, R1315C, I1566V, K2140R, T2163I, H2285Y, Q2425R; ORF3a: A72T, A110V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}},"children":[{"name":"XCT.1","node_attrs":{"div":111,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":109,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCT"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCT"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","D335G","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","L3829F"],"ORF1b":["T76A","P314L","G662S","S959P","R1315C","I1566V","D1746Y","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, D335G, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, L3829F; ORF1b: T76A, P314L, G662S, S959P, R1315C, I1566V, D1746Y, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDA.1","node_attrs":{"div":108,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":105,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDA"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.041689999999999984"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDA"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-18"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18657T","C18894T","C19716T","C19955T","A20055G","C21618T","C21622T","G21624C","C21627A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25006T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28291A","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G28884C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204P","Q229K","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P3H","P10S","E27-","N28-","A29-"],"S":["R21T","T22N","L24-","P25-","P26-","A27S","S50L","F59S","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204P, Q229K, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P3H, P10S, E27-, N28-, A29-; S: R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L","spike_mutations":"R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":133,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":29.34},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-14"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"ORF1a":["A599T","L4182F"],"S":["K182R"]},"labels":{"aa":"ORF1a: A599T, L4182F; S: K182R","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":127,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XEC"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":34.028},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XEC"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4006A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17067C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","T26012G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["F207C","T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: F207C, T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCF","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":93,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XCF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.18829999999999997"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XCF.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T170I","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T170I, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.758352756500244}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"ORF1a":["H388Y","L397P"],"S":["E1092D"]},"labels":{"aa":"ORF1a: H388Y, L397P; S: E1092D","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDP.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2668T","C2790T","C3037T","G4184A","C4321T","C6896T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"ORF1a":["A1938S"],"S":["F59S","R346T"]},"labels":{"aa":"ORF1a: A1938S; S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.1","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF1a":["A2142V"],"ORF1b":["A2480D"],"ORF8":["E92K"],"S":["F456L"]},"labels":{"aa":"ORF1a: A2142V; ORF1b: A2480D; ORF8: E92K; S: F456L","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":122,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDR.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDR.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"ORF1a":["L3754F"],"ORF1b":["L1890F"]},"labels":{"aa":"ORF1a: L3754F; ORF1b: L1890F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G3446A","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","A20379G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","A1061T","S1221L","G1307S","P1640S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, A1061T, S1221L, G1307S, P1640S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBL","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":96,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.1","node_attrs":{"div":99,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"XBL.2","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"NODE_0000016","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3","node_attrs":{"div":98,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"XBL.3.1","node_attrs":{"div":102,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBL.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0124"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBL.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","C7420T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A27980G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","T29023C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","A211D","T842I","V1056L","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, A211D, T842I, V1056L, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K","spike_mutations":"R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDQ","node_attrs":{"div":113,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":114,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.493660926818848}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.2","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"ORF1a":["F2802C"],"S":["N487D"]},"labels":{"aa":"ORF1a: F2802C; S: N487D","spike_mutations":"N487D"}}},{"name":"XDQ.3","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-18"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"NODE_0000019","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.296816825866699}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1.1","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDQ.1","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDQ.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.296816825866699}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1471T","C2445T","C2790T","C3037T","G3072A","G4184A","C4321T","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10189T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C12880T","C14408T","C15714T","C17410T","C17678T","A18163G","C18252T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22020C","T22054G","T22200G","C22295A","G22332A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893G","A22910G","C22916A","T22942G","G22992A","C22995A","G23012A","A23013G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25896T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T727I","T842I","C936Y","G1307S","I1714T","M2169V","T2174I","A2584V","T2648I","A2909V","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","Q3922R"],"ORF1b":["P314L","R1315C","T1404M","I1566V","T2163I"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","M153T","N164K","V213G","H245N","G257D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444R","N450D","L452M","N460K","S477N","T478K","E484R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T727I, T842I, C936Y, G1307S, I1714T, M2169V, T2174I, A2584V, T2648I, A2909V, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, Q3922R; ORF1b: P314L, R1315C, T1404M, I1566V, T2163I; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBJ","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000021","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.2","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"ORF1a":["K2928N"]},"labels":{"aa":"ORF1a: K2928N"}}},{"name":"XBJ.4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBJ.1.1","node_attrs":{"div":97,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBJ.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","A690V","T842I","G1307S","G1819S","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, A690V, T842I, G1307S, G1819S, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":115,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":116,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.604482173919678}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.2","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"XDD.3","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"ORF1b":["T2048A"],"S":["F456L","T572I"]},"labels":{"aa":"ORF1b: T2048A; S: F456L, T572I","spike_mutations":"F456L, T572I"}}},{"name":"NODE_0000025","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDD.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDD.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","C23277T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","K1973R","N2526S","A2710T","L3027F","T3090I","T3255I","P3395H","V3593F","S3675-","G3676-","F3677-","R3821K","T4175I"],"ORF1b":["P314L","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","T572I","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF1a: K47R, S135R, T842I, G1307S, K1973R, N2526S, A2710T, L3027F, T3090I, T3255I, P3395H, V3593F, S3675-, G3676-, F3677-, R3821K, T4175I; ORF1b: P314L, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":118,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":119,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.2","node_attrs":{"div":125,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","C22928T","A23598G","C27297T"],"S":["L456F","K679R"]},"labels":{"aa":"S: L456F, K679R","spike_mutations":"L456F, K679R"}}},{"name":"XDK.3","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"ORF1a":["F3397L"]},"labels":{"aa":"ORF1a: F3397L"}}},{"name":"XDK.5","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.635818004608154}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"internal_0964eaa1","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":121,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"XDK.4.1","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T"],"ORF1a":["T708I","A1082V"],"ORF1b":["P1727S"]},"labels":{"aa":"ORF1a: T708I, A1082V; ORF1b: P1727S"}}}]},{"name":"internal_C29762T","node_attrs":{"div":120,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":126,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, Q1201K","spike_mutations":"R237K, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":123,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G11596A","C18664T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.2","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.803860664367676}},"branch_attrs":{"mutations":{"nuc":["G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"NODE_0000032","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}},"children":[{"name":"XDK.1","node_attrs":{"div":124,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{}}},{"name":"XDK.1.1","node_attrs":{"div":129,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.0469899999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDK.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","T18664C","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["C241T","G625T","T670G","C1627T","C2790T","C3037T","T3339C","G4184A","C4321T","C6070T","C8692T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K120N","S135R","T842I","V1025A","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","N4060S"],"ORF1b":["P314L","G662S","R1315C","I1566V","V1706I","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K120N, S135R, T842I, V1025A, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, N4060S; ORF1b: P314L, G662S, R1315C, I1566V, V1706I, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBF","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000034","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.2","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.335100173950195}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.10","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.3","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"ORF1a":["V274I"]},"labels":{"aa":"ORF1a: V274I"}}},{"name":"XBF.4","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"ORF1a":["H417Y"]},"labels":{"aa":"ORF1a: H417Y"}}},{"name":"XBF.5","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.6","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"ORF1a":["V3986A"]},"labels":{"aa":"ORF1a: V3986A"}}},{"name":"XBF.9","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"ORF1b":["S1003G"]},"labels":{"aa":"ORF1b: S1003G"}}},{"name":"NODE_0000035","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-08"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"ORF1a":["G1155C"],"S":["P621S"]},"labels":{"aa":"ORF1a: G1155C; S: P621S","spike_mutations":"P621S"}}}]},{"name":"NODE_0000036","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"ORF1a":["N120K"]},"labels":{"aa":"N: T379I; ORF1a: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"ORF1b":["Q1878E"],"S":["T323I"]},"labels":{"aa":"ORF1b: Q1878E; S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0000037","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":94,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBF.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBF.8.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"ORF1a":["K141-","S142-","F143-"],"S":["P621S"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; S: P621S","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C12880T","C14408T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","A21623G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23423T","C23525T","T23599G","C23604A","C23679T","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","C26681T","T26767C","G26959A","C27575G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"M":["I82T","R146H"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["S135R","T842I","G1307S","P2287S","T2777I","V2930L","T3255I","P3395H","S3675-","G3676-","F3677-","T4161I"],"ORF1b":["P314L","A520V","G662S","P1000L","A1918V"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["T61S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L18F","I19R","R21G","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","P621S","H655Y","N679K","P681H","A706V","N764K","D796Y","Q954H","N969K","T1117I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: S135R, T842I, G1307S, P2287S, T2777I, V2930L, T3255I, P3395H, S3675-, G3676-, F3677-, T4161I; ORF1b: P314L, A520V, G662S, P1000L, A1918V; ORF3a: S26L; ORF6: L61D; ORF7a: T61S; ORF9b: P10S, E27-, N28-, A29-; S: L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I","spike_mutations":"L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-25"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000039","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"ORF1b":["D1869Y"]},"labels":{"aa":"ORF1b: D1869Y"}}},{"name":"NODE_0000040","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.996061325073242}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"ORF1a":["Y3765C"]},"labels":{"aa":"ORF1a: Y3765C"}},"children":[{"name":"XAY.2","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.996061325073242}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000041","node_attrs":{"div":81,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15492057800293}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"ORF1a":["I3126T"]},"labels":{"aa":"ORF1a: I3126T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000217437744141}},"branch_attrs":{"mutations":{"nuc":["C657T"],"ORF1a":["A131V"]},"labels":{"aa":"ORF1a: A131V"}}},{"name":"NODE_0000042","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.15492057800293}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796271324157715}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.2.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.6994194984436035}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"ORF1a":["R124C","N447S"]},"labels":{"aa":"ORF1a: R124C, N447S"}}}]}]}]},{"name":"NODE_0000043","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.522014617919922}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"ORF1a":["D48N","I3052V","Q3346K"],"S":["D253G"]},"labels":{"aa":"ORF1a: D48N, I3052V, Q3346K; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.522014617919922}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6144499999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF1a":["T3646I"],"ORF9b":["S50L"]},"labels":{"aa":"ORF1a: T3646I; ORF9b: S50L"}}},{"name":"NODE_0000044","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"ORF1a":["K2108N"],"S":["R346T"]},"labels":{"aa":"ORF1a: K2108N; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.397461414337158}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF7a":["S61T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF7a: S61T"}}},{"name":"NODE_0000045","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097011089324951}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000046","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":90,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.3"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.778554439544678}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"ORF1a":["P1640S"]},"labels":{"aa":"ORF1a: P1640S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.16986083984375}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000047","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.697335243225098}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6888599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752889267417711"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.495386123657227}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":95,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.72587"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XAY.1.1.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-7.971493244171143}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF1a":["S723P"],"ORF9b":["R13L"]},"labels":{"aa":"ORF1a: S723P; ORF9b: R13L"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","S302F","T842I","G1307S","P2079Q","T2283I","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-","P4220L"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, S302F, T842I, G1307S, P2079Q, T2283I, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-, P4220L; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF7b: F19L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":117,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XDV"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000049","node_attrs":{"div":119,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1.1","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":125,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.10"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"ORF1a":["T4175I"],"S":["G181V"]},"labels":{"aa":"ORF1a: T4175I; S: G181V","spike_mutations":"G181V"}}},{"name":"XDV.1","node_attrs":{"div":119,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.11","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.11"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.6","node_attrs":{"div":126,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"ORF1a":["E1209D","T1429I","V1783I"]},"labels":{"aa":"ORF1a: E1209D, T1429I, V1783I"}}},{"name":"XDV.1.4","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.5","node_attrs":{"div":124,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.14808999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5359962252743784"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.8","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000050","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"ORF1a":["L3116F"],"S":["R346T"]},"labels":{"aa":"N: I292T; ORF1a: L3116F; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2.1","node_attrs":{"div":127,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":6.25},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.26874999999999993"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.8051577060608006"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"ORF1a":["L3829F"],"S":["K462R"]},"labels":{"aa":"ORF1a: L3829F; S: K462R","spike_mutations":"K462R"}}},{"name":"XDV.1.2","node_attrs":{"div":122,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.3181399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000051","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"ORF1a":["D2980N"]},"labels":{"aa":"ORF1a: D2980N"}},"children":[{"name":"XDV.1.7","node_attrs":{"div":121,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.7.1","node_attrs":{"div":126,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.7.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"ORF1a":["L681F"],"S":["T22N","V62F"]},"labels":{"aa":"ORF1a: L681F; S: T22N, V62F","spike_mutations":"T22N, V62F"}}}]},{"name":"NODE_0000052","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"clade_membership":{"value":"24D"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"ORF1a":["T2197I"]},"labels":{"aa":"ORF1a: T2197I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":120,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20671999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-17"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":123,"clade_display":{"value":"24D (XDV.1)"},"Nextclade_pango":{"value":"XDV.1.9.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24D"},"ace2_binding":{"value":"0.20783000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XDV.1.9.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5422010449483097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","C9891T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23670T","C23854A","G23948T","A24424T","T24469A","C25000T","C25854T","T26767C","T26819C","T27718C","C27752T","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF1a":["S135R","T842I","T1543I","P1640L","S2104I","V2276I","A3209V","V3718A","T3750I"],"ORF1b":["P314L","G662S","P1000L","T1050I"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["T60A"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","P209L","L212S","D215H","A222V","L242-","A243-","S256L","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N703I","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF1a: S135R, T842I, T1543I, P1640L, S2104I, V2276I, A3209V, V3718A, T3750I; ORF1b: P314L, G662S, P1000L, T1050I; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: T60A; S: P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBC","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6871599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000054","node_attrs":{"div":67,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000055","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"ORF1a":["V2865I"],"S":["K97R"]},"labels":{"aa":"ORF1a: V2865I; S: K97R","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":72,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"recombinant"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"ace2_binding":{"value":"0.6871599999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"partiallyAliased":{"value":"XBC.2"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.2616082621302063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF1a":["A498V"],"ORF8":["D34-"]},"labels":{"aa":"ORF1a: A498V; ORF8: D34-"}}},{"name":"XBC.2.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.58838"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.2.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.44507236664312827"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF1a":["G1307S"],"ORF8":["A15T"],"S":["K444T"]},"labels":{"aa":"ORF1a: G1307S; ORF8: A15T; S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000056","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"ORF1a":["S391F"],"S":["L452M"]},"labels":{"aa":"ORF1a: S391F; S: L452M","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":69,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"recombinant"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"partiallyAliased":{"value":"XBC.1"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000057","node_attrs":{"div":70,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"ORF1a":["T3255I"]},"labels":{"aa":"ORF1a: T3255I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.4"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"ORF1a":["G82-","H83-","V84-","P3952S","V4072A"],"ORF1b":["T794P"],"S":["G184S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, P3952S, V4072A; ORF1b: T794P; S: G184S","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":74,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.5"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"ORF1a":["T708I","A1997V"]},"labels":{"aa":"ORF1a: T708I, A1997V"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBC.1.2"},"totalAminoacidDeletions":{"value":7},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}},{"name":"XBC.1.2.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.2.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}}}]},{"name":"NODE_0000059","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF1a":["K141-","S142-","F143-","I3619T"],"ORF8":["V114L"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I3619T; ORF8: V114L"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.805704593658447}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000060","node_attrs":{"div":78,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1.2"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF1a":["R124C"],"ORF3a":["P262L"],"ORF7a":["P34L"]},"labels":{"aa":"ORF1a: R124C; ORF3a: P262L; ORF7a: P34L"}}},{"name":"XBC.1.1.1","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.11213999999999996"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.1.1"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.48837241784414276"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}}]}]},{"name":"NODE_0000061","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF1b":["Y1247C"],"ORF7a":["T14I"],"S":["K444T","K478R"]},"labels":{"aa":"ORF1b: Y1247C; ORF7a: T14I; S: K444T, K478R","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":75,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.5473299999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.7.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6307633281941917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"ORF1a":["V1006I"],"S":["T299I"]},"labels":{"aa":"ORF1a: V1006I; S: T299I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000062","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":71,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000063","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","Q455K","V2061A","T4174I"],"ORF1b":["S759N"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, Q455K, V2061A, T4174I; ORF1b: S759N; ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":77,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"ORF1a":["E933V"]},"labels":{"aa":"ORF1a: E933V"}},"children":[{"name":"KD.1","node_attrs":{"div":79,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.7857899999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF1a":["M3661L","M3934I"],"ORF3a":["T151I"]},"labels":{"aa":"ORF1a: M3661L, M3934I; ORF3a: T151I"}}},{"name":"KD.4","node_attrs":{"div":82,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"ORF1a":["K394R","L730F","T965I"]},"labels":{"aa":"ORF1a: K394R, L730F, T965I"}}},{"name":"KD.3","node_attrs":{"div":80,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"KD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.79272"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"totalAminoacidDeletions":{"value":21},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}}]}]}]},{"name":"NODE_0000065","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"ORF1a":["A690V","C1114F","H2659Y"],"ORF1b":["I1256V"],"S":["R346S","M452R"]},"labels":{"aa":"ORF1a: A690V, C1114F, H2659Y; ORF1b: I1256V; S: R346S, M452R","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":83,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"ORF1a":["D827N"]},"labels":{"aa":"ORF1a: D827N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.4"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"ORF1a":["V1117I"]},"labels":{"aa":"ORF1a: V1117I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.5"},"totalAminoacidDeletions":{"value":11},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF1a":["G82-","H83-","V84-","M85V"],"ORF1b":["R712C"],"ORF7a":["Q90*"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; ORF1b: R712C; ORF7a: Q90*"}}},{"name":"NODE_0000066","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":87,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"GT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":84,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000067","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"JT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.47217000000000003"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7550301657183831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"S":["V445A"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; S: V445A","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":86,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.6"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":85,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":85,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"XBC.1.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000069","node_attrs":{"div":88,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"clade_membership":{"value":"recombinant"},"clade_who":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"ORF1a":["T1597I","A2123V"]},"labels":{"aa":"ORF1a: T1597I, A2123V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":91,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.63844"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.7420325830319254"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}},{"name":"HW.1.2","node_attrs":{"div":89,"clade_display":{"value":"recombinant"},"Nextclade_pango":{"value":"HW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"recombinant"},"ace2_binding":{"value":"0.6392699999999999"},"clade_who":{"value":"recombinant"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"totalAminoacidDeletions":{"value":8},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"recombinant"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF1a":["K47R","S135R","T842I","G1307S","L3027F","T3090I","L3201F","T3255I","P3395H","S3675-","G3676-","F3677-"],"ORF1b":["P314L","G662S","S959P","R1315C","I1566V","T2163I"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF1a: K47R, S135R, T842I, G1307S, L3027F, T3090I, L3201F, T3255I, P3395H, S3675-, G3676-, F3677-; ORF1b: P314L, G662S, S959P, R1315C, I1566V, T2163I; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K","clade":"22F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBB","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000071","node_attrs":{"div":88,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.3498640060424805}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000072","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"ORF1a":["G82D"]},"labels":{"aa":"ORF1a: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"ORF1a":["V2866M","V3751F"]},"labels":{"aa":"N: T49I; ORF1a: V2866M, V3751F"}}},{"name":"NODE_0000073","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.3064099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.26627999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0810114368008295"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"ORF1a":["N1651K"],"S":["L5F","T470N"]},"labels":{"aa":"ORF1a: N1651K; S: L5F, T470N","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000074","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000075","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.41795539855957}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000076","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}}},{"name":"XBB.8.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"ORF1a":["K634N","K3353R"]},"labels":{"aa":"ORF1a: K634N, K3353R"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"ORF1b":["I1998V"]},"labels":{"aa":"ORF1b: I1998V"}},"children":[{"name":"XBB.3","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.830664157867432}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"NODE_0000079","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"ORF1b":["A520T"],"S":["V1122L"]},"labels":{"aa":"ORF1b: A520T; S: V1122L","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122063159942627}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.122063159942627}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.5","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.636688709259033}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.1652350425720215}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.8","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.256869792938232}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"ORF1a":["V2027I"],"S":["S486P"]},"labels":{"aa":"ORF1a: V2027I; S: S486P","spike_mutations":"S486P"}}},{"name":"NODE_0000081","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143524169922}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XBB.2.11.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}},{"name":"XBB.2.11","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.454143524169922}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000082","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"ORF1a":["R3662H"]},"labels":{"aa":"ORF1a: R3662H"}},"children":[{"name":"XBB.2.7","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.219923973083496}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.7.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65097"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"ORF1a":["E250D"],"S":["Y453F","K478Q"]},"labels":{"aa":"ORF1a: E250D; S: Y453F, K478Q","spike_mutations":"Y453F, K478Q"}}}]},{"name":"NODE_0000083","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.832684516906738}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"internal_d796","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.6237757205963135}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.2.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.35217"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":96,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF1a":["G2091S"],"ORF1b":["P959S"],"ORF7a":["A13V"],"S":["S486P","P521S"]},"labels":{"aa":"ORF1a: G2091S; ORF1b: P959S; ORF7a: A13V; S: S486P, P521S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":96,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF1b":["A241T"],"ORF7a":["H47Y"],"S":["D80Y"]},"labels":{"aa":"ORF1b: A241T; ORF7a: H47Y; S: D80Y","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.0750199999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2567103717994188"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.21","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"ORF1a":["R135S","D3042N"],"S":["T883I"]},"labels":{"aa":"ORF1a: R135S, D3042N; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.20","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.5","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.456076145172119}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.92117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}},"children":[{"name":"JA.1","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84789"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0527558336884004"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.90647"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.901963710784912}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"ORF1a":["D2907N"]},"labels":{"aa":"ORF1a: D2907N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.84876"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"ORF1a":["I4308V"]},"labels":{"aa":"ORF1a: I4308V"}},"children":[{"name":"JS.1","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"JS.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"ORF1a":["M3669I"],"S":["T323I"]},"labels":{"aa":"ORF1a: M3669I; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.2.3.15","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"ORF1a":["P1786L"],"S":["G184V"]},"labels":{"aa":"ORF1a: P1786L; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"ORF1a":["P3504L"],"ORF1b":["K2579R"],"S":["K478T","E654K"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: K2579R; S: K478T, E654K","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.88039"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"ORF1a":["R4017K"]},"labels":{"aa":"ORF1a: R4017K"}},"children":[{"name":"GM.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GM.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89932"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736186906064397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"ORF1a":["S3099L"],"S":["N388K"]},"labels":{"aa":"ORF1a: S3099L; S: N388K","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"ORF1a":["A583V","L3829F"],"S":["K478R"]},"labels":{"aa":"ORF1a: A583V, L3829F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"ORF1a":["I2786V"]},"labels":{"aa":"ORF1a: I2786V"}},"children":[{"name":"HG.3","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"ORF1a":["S2273F"],"S":["S255F"]},"labels":{"aa":"ORF1a: S2273F; S: S255F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HG.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000101","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.7709600000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0079043361863298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF1a":["L4111F"],"ORF3a":["I179V"]},"labels":{"aa":"ORF1a: L4111F; ORF3a: I179V"}}}]},{"name":"NODE_0000102","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.295289993286133}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.6"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"ORF1a":["I114V","K1212-","P1213-","F1214-","S2631P","V3166I"],"ORF1b":["A572V","H1087Y"],"S":["A845S"]},"labels":{"aa":"ORF1a: I114V, K1212-, P1213-, F1214-, S2631P, V3166I; ORF1b: A572V, H1087Y; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000103","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.607783317565918}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"ORF1b":["F2330L"],"S":["R190S"]},"labels":{"aa":"ORF1b: F2330L; S: R190S","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"ORF1a":["L204I"]},"labels":{"aa":"ORF1a: L204I"}},"children":[{"name":"GS.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.293885707855225}},"branch_attrs":{"mutations":{}}},{"name":"GS.7.1","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"ORF1a":["G519S"],"S":["E180Q"]},"labels":{"aa":"ORF1a: G519S; S: E180Q","spike_mutations":"E180Q"}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"ORF1a":["T1822I"],"S":["Q218H"]},"labels":{"aa":"ORF1a: T1822I; S: Q218H","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"ORF1a":["A181T"]},"labels":{"aa":"ORF1a: A181T"}},"children":[{"name":"GS.4","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GS.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"ORF1a":["R2159W"],"S":["G184V"]},"labels":{"aa":"ORF1a: R2159W; S: G184V","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF1a":["L293I","P4197S"],"ORF8":["T26I"],"S":["K147N"]},"labels":{"aa":"ORF1a: L293I, P4197S; ORF8: T26I; S: K147N","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF1a":["D935E"],"ORF8":["G8R"],"S":["K478R"]},"labels":{"aa":"ORF1a: D935E; ORF8: G8R; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bb69915a","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"NODE_0000112","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"ORF1a":["T2977I"]},"labels":{"aa":"ORF1a: T2977I"}},"children":[{"name":"HH.1.1","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"HH.1","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"ORF1a":["D48Y"]},"labels":{"aa":"ORF1a: D48Y"}},"children":[{"name":"HH.2.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"ORF1a":["S3344F"],"ORF1b":["T2537I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S3344F; ORF1b: T2537I; S: K478R","spike_mutations":"K478R"}}},{"name":"HH.2","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"HH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":99,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1b":["I1403V"]},"labels":{"aa":"ORF1b: I1403V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"ORF1a":["P3359S"]},"labels":{"aa":"ORF1a: P3359S"}}},{"name":"GE.1.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"NODE_0000118","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"ORF1a":["G661S"]},"labels":{"aa":"ORF1a: G661S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF1a":["A4148T"],"S":["L118I"]},"labels":{"aa":"ORF1a: A4148T; S: L118I","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF1a":["P1921S","V4369A"],"ORF7a":["P99S"],"S":["N148T"]},"labels":{"aa":"ORF1a: P1921S, V4369A; ORF7a: P99S; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.70075"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.986824739722089"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF1b":["A517V","D1899E"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF1b: A517V, D1899E; ORF6: L61H; ORF7b: F19L; S: S408N","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF3a":["S195C"],"S":["A376S","R478T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF3a: S195C; S: A376S, R478T","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GE.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":111,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":111,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":112,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":114,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":114,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KT.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.95933"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9661216382902195"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"ORF1b":["N2328S"]},"labels":{"aa":"ORF1b: N2328S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":97,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":98,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.203644752502441}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.2","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"ORF1b":["T794I"],"S":["I1114S"]},"labels":{"aa":"ORF1b: T794I; S: I1114S","spike_mutations":"I1114S"}}},{"name":"GJ.3","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"ORF1a":["P971S"],"ORF1b":["V2371L"]},"labels":{"aa":"ORF1a: P971S; ORF1b: V2371L"}}},{"name":"GJ.6","node_attrs":{"div":102,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.13359999999999994"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1722153044473287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"ORF1a":["T891I","Y1814C"],"S":["F456L"]},"labels":{"aa":"M: G6S; ORF1a: T891I, Y1814C; S: F456L","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"ORF1b":["P1727S"],"S":["E183K"]},"labels":{"aa":"ORF1b: P1727S; S: E183K","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"ORF1a":["A540V","A3963V"],"S":["S255F"]},"labels":{"aa":"ORF1a: A540V, A3963V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.5","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF1a":["I4205V"],"ORF8":["E106Q"]},"labels":{"aa":"ORF1a: I4205V; ORF8: E106Q"}},"children":[{"name":"GJ.1","node_attrs":{"div":100,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":101,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"ORF1a":["V1915I","N2228S"],"S":["A222V"]},"labels":{"aa":"N: R319H; ORF1a: V1915I, N2228S; S: A222V","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"ORF1b":["V1110I"]},"labels":{"aa":"ORF1b: V1110I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":103,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":107,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF1a":["G1152C"],"ORF9b":["I5T"],"S":["K478R"]},"labels":{"aa":"ORF1a: G1152C; ORF9b: I5T; S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"ORF1a":["H919Y"]},"labels":{"aa":"ORF1a: H919Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF1a":["C2160Y"],"ORF8":["G8V"],"S":["S255F"]},"labels":{"aa":"ORF1a: C2160Y; ORF8: G8V; S: S255F","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.5","node_attrs":{"div":106,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}},{"name":"GJ.1.2.6","node_attrs":{"div":105,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.452496528625488}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_18110768","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":104,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"GJ.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.89912"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0248043607383275"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":108,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":109,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"clade_membership":{"value":"23E"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":110,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"JE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":115,"clade_display":{"value":"23E (XBB.2.3)"},"Nextclade_pango":{"value":"KH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23E"},"ace2_binding":{"value":"0.75251"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0453841240781256"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23E"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF1a":["R135S"],"ORF7a":["V71L"],"S":["E554K"]},"labels":{"aa":"N: L13F; ORF1a: R135S; ORF7a: V71L; S: E554K","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.062752723693848}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1.10","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13558"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1","node_attrs":{"div":89,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.062752723693848}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.3","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.49564"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"ORF1a":["P2287S"],"S":["A484T"]},"labels":{"aa":"ORF1a: P2287S; S: A484T","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"ORF1b":["L1061I"],"S":["S486P"]},"labels":{"aa":"ORF1b: L1061I; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0545"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.33"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-18"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF1a":["V84-","M85-","T1665I","Q2486P"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"]},"labels":{"aa":"ORF1a: V84-, M85-, T1665I, Q2486P; ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.89405"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.49"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"ORF1a":["R124C"],"S":["T346S"]},"labels":{"aa":"ORF1a: R124C; S: T346S","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54201602935791}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF1a":["P4312T"],"ORF3a":["A72V"]},"labels":{"aa":"ORF1a: P4312T; ORF3a: A72V"}}},{"name":"XBB.1.48","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.9722600000000003"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.48"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.339816093444824}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"ORF1a":["T2069I"],"S":["P521S"]},"labels":{"aa":"ORF1a: T2069I; S: P521S","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"ORF1a":["T1638I","P2046S"],"S":["D936G"]},"labels":{"aa":"ORF1a: T1638I, P2046S; S: D936G","spike_mutations":"D936G"}}},{"name":"GW.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"ORF1a":["S100N","N3537S"]},"labels":{"aa":"ORF1a: S100N, N3537S"}}},{"name":"GW.4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"ORF1a":["M3280I"]},"labels":{"aa":"ORF1a: M3280I"}}},{"name":"XBB.1.19.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF1a":["D264N"],"ORF9b":["T79I"]},"labels":{"aa":"N: M322V; ORF1a: D264N; ORF9b: T79I"}},"children":[{"name":"GW.1.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}}},{"name":"GW.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000141","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"ORF1a":["S302F","P2079Q","P4220L"],"S":["L455F","F456L","K478I"]},"labels":{"aa":"N: P80S; ORF1a: S302F, P2079Q, P4220L; S: L455F, F456L, K478I","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":114,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"ORF1a":["I694V"],"S":["G184A","A475V"]},"labels":{"aa":"ORF1a: I694V; S: G184A, A475V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":110,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.42535999999999996"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":116,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF1a":["P62L"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"]},"labels":{"aa":"ORF1a: P62L; ORF3a: G172C; ORF6: L61H; S: F79S, A475V","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":116,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GW.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.2","node_attrs":{"div":121,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"ORF1a":["A2584V"],"S":["S704L"]},"labels":{"aa":"ORF1a: A2584V; S: S704L","spike_mutations":"S704L"}}},{"name":"KE.1","node_attrs":{"div":121,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.3","node_attrs":{"div":118,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"KE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-1.1446900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"ORF1a":["L3641S"],"ORF1b":["T730I"]},"labels":{"aa":"ORF1a: L3641S; ORF1b: T730I"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":90,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.1269190311431885}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86729"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"ORF1a":["K1247R"],"S":["S486A"]},"labels":{"aa":"ORF1a: K1247R; S: S486A","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.2602599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"ORF1b":["N79I"],"S":["K478R","A890V"]},"labels":{"aa":"ORF1b: N79I; S: K478R, A890V","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"ORF1a":["G3617C","L3829F"],"S":["A292S"]},"labels":{"aa":"ORF1a: G3617C, L3829F; S: A292S","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF1a":["G519S","L2609F"],"ORF3a":["P104S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: G519S, L2609F; ORF3a: P104S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.88502836227417}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"ORF1a":["K1051N"],"S":["V608I"]},"labels":{"aa":"ORF1a: K1051N; S: V608I","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"ORF1a":["C873F","H2520Q"],"S":["Q146K","L216F"]},"labels":{"aa":"ORF1a: C873F, H2520Q; S: Q146K, L216F","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3930888175964355}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"ORF1a":["S216F","A2832V"],"ORF1b":["D251N","T634A"],"S":["Y453F"]},"labels":{"aa":"ORF1a: S216F, A2832V; ORF1b: D251N, T634A; S: Y453F","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-09"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.12.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"ORF1a":["T614I"],"S":["Q613H","E1202Q"]},"labels":{"aa":"ORF1a: T614I; S: Q613H, E1202Q","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.726885795593262}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18493000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"ORF1a":["T2186A"],"S":["Q564E","N856K"]},"labels":{"aa":"ORF1a: T2186A; S: Q564E, N856K","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000148","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.14.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}},"children":[{"name":"XBB.1.15","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.15.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8d12","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.231657028198242}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.37.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.37.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.37.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_234859ae","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.930481910705566}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.38.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_97a057d5","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253978252410889}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.43.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.43.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"ORF1a":["A2621V"],"S":["S486P"]},"labels":{"aa":"ORF1a: A2621V; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_fcda1063","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.44.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.44.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF1a":["A540V"],"ORF3a":["S195F"],"S":["S486P"]},"labels":{"aa":"ORF1a: A540V; ORF3a: S195F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306640625}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.039306640625}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.45.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.45.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.45.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000155","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"ORF1a":["P309L","W2232C"],"S":["Y453F","K478R"]},"labels":{"aa":"ORF1a: P309L, W2232C; S: Y453F, K478R","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF1a":["H1160Y","L3588F"],"ORF3a":["V197L"],"S":["E554K"]},"labels":{"aa":"ORF1a: H1160Y, L3588F; ORF3a: V197L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.31.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.54089"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.31.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"ORF1a":["A1049V"]},"labels":{"aa":"ORF1a: A1049V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}},{"name":"XBB.1.4.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"ORF1a":["V3595F"],"S":["S486P"]},"labels":{"aa":"ORF1a: V3595F; S: S486P","spike_mutations":"S486P"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF1b":["V1092I"],"ORF9b":["R47C"],"S":["S486P","H681R"]},"labels":{"aa":"N: A50V; ORF1b: V1092I; ORF9b: R47C; S: S486P, H681R","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-20"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"ORF1b":["P970L"],"S":["E554K"]},"labels":{"aa":"ORF1b: P970L; S: E554K","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF1a":["G989C"],"ORF8":["C90F"],"S":["K182I"]},"labels":{"aa":"ORF1a: G989C; ORF8: C90F; S: K182I","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.34.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.34.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296722412109375}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.751910209655762}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"XBB.1.39","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.072850704193115}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"ORF1a":["V2866M"]},"labels":{"aa":"ORF1a: V2866M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"ORF1a":["E148D"]},"labels":{"aa":"ORF1a: E148D"}},"children":[{"name":"XBB.1.32","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.32.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF1a":["L642F","T2121I"],"ORF1b":["L2497I"],"ORF7a":["A50S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: L642F, T2121I; ORF1b: L2497I; ORF7a: A50S; S: Y453F","spike_mutations":"Y453F"}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.578298091888428}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.05231"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"ORF1b":["S2212I"],"S":["L335S"]},"labels":{"aa":"ORF1b: S2212I; S: L335S","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"ORF1a":["D2627N"]},"labels":{"aa":"ORF1a: D2627N"}}},{"name":"FW.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.2"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.09468412399292}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"ORF1a":["G82-","H83-","V84-","M85V","G2258C"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, G2258C"}}},{"name":"XBB.1.28.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.28.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.8561224937438965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF1a":["V84-","M85-"],"ORF6":["F2-"],"S":["A701V"]},"labels":{"aa":"ORF1a: V84-, M85-; ORF6: F2-; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.344549655914307}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF1a":["S838N","A4285T"],"ORF1b":["I1448L"],"ORF7a":["E121*"],"S":["N148T"]},"labels":{"aa":"ORF1a: S838N, A4285T; ORF1b: I1448L; ORF7a: E121*; S: N148T","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:3-62"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":106,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.13254"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"1.2584103390429446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF1a":["S2285F","K3353R"],"ORF6":["-2F","L61H"],"S":["A684T"]},"labels":{"aa":"ORF1a: S2285F, K3353R; ORF6: -2F, L61H; S: A684T","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"ORF1a":["T2016I"],"S":["-24L","S27-","H69-","V70-"]},"labels":{"aa":"ORF1a: T2016I; S: -24L, S27-, H69-, V70-","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FP.4","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"XBB.1.11.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"ORF1a":["V3078I"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3078I; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF1a":["I693T","T951A"],"ORF3a":["W149C"],"S":["K478R"]},"labels":{"aa":"ORF1a: I693T, T951A; ORF3a: W149C; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.7388600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FP.2.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"ORF1a":["F143Y"],"S":["P521S"]},"labels":{"aa":"ORF1a: F143Y; S: P521S","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.9296722412109375}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"XBB.1.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"ORF1a":["V89A"]},"labels":{"aa":"ORF1a: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.46"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"ORF1a":["C1114F"]},"labels":{"aa":"ORF1a: C1114F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF1a":["T1761I","C2180Y","I2854V"],"ORF8":["Q18*"]},"labels":{"aa":"ORF1a: T1761I, C2180Y, I2854V; ORF8: Q18*"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.47.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.47.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"ORF1a":["K669N"],"S":["A260V","S486P","V1122G"]},"labels":{"aa":"ORF1a: K669N; S: A260V, S486P, V1122G","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"ORF1a":["K120R"],"S":["S486P"]},"labels":{"aa":"ORF1a: K120R; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.24.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.05408"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"NODE_0000173","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"XBB.1.24.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}},{"name":"XBB.1.24.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.24.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.24.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"ORF1a":["D2579G"]},"labels":{"aa":"ORF1a: D2579G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.696715831756592}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.35757303237915}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000176","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF1a":["S1133G"],"ORF3a":["F207C"],"S":["F456L"]},"labels":{"aa":"ORF1a: S1133G; ORF3a: F207C; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"NODE_0000177","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.4","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.5","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FE.1.1.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"ORF1a":["Q991H"],"S":["K1086R"]},"labels":{"aa":"ORF1a: Q991H; S: K1086R","spike_mutations":"K1086R"}}},{"name":"NODE_0000178","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FE.1.1.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"ORF1a":["T403I"],"ORF1b":["S2212I"],"S":["L335S","R403K","S486P"]},"labels":{"aa":"ORF1a: T403I; ORF1b: S2212I; S: L335S, R403K, S486P","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.6066099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1099290580037755"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"ORF1b":["A186T"],"S":["S494P"]},"labels":{"aa":"ORF1b: A186T; S: S494P","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.65784"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.079714171690073"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"ORF1a":["L397F"],"S":["K478R"]},"labels":{"aa":"ORF1a: L397F; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"ORF1b":["Y1200H"],"S":["Q14K"]},"labels":{"aa":"ORF1b: Y1200H; S: Q14K","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"ORF1a":["P1220L"]},"labels":{"aa":"N: H300Y; ORF1a: P1220L"}},"children":[{"name":"JC.5","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"ORF1a":["G98S"],"S":["Q173K"]},"labels":{"aa":"ORF1a: G98S; S: Q173K","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"S":["N703I"]},"labels":{"aa":"S: N703I","spike_mutations":"N703I"}}},{"name":"JC.4","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.51123"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}},{"name":"JC.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"JC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.43418"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.41.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.100757948723013"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"ORF1a":["V1056L"],"S":["H339R"]},"labels":{"aa":"ORF1a: V1056L; S: H339R","spike_mutations":"H339R"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"ORF1a":["L469F"]},"labels":{"aa":"ORF1a: L469F"}},"children":[{"name":"XBB.1.17.2","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"ORF1a":["A698S"]},"labels":{"aa":"ORF1a: A698S"}}},{"name":"XBB.1.17","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000188","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"ORF1a":["G728C"]},"labels":{"aa":"ORF1a: G728C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"ORF1b":["V2236I"]},"labels":{"aa":"ORF1b: V2236I"}},"children":[{"name":"GA.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"ORF1b":["A186V"]},"labels":{"aa":"ORF1b: A186V"}}},{"name":"GA.5","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}},"children":[{"name":"GA.10.1","node_attrs":{"div":111,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-03"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF1a":["I368V","A776V","F1214S","S2103F"],"ORF1b":["K1947R"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"]},"labels":{"aa":"M: H125Y, R146H; ORF1a: I368V, A776V, F1214S, S2103F; ORF1b: K1947R; ORF9b: T95M; S: L455F, F456L, K478R","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.10","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"ORF1a":["I2138V"]},"labels":{"aa":"ORF1a: I2138V"}},"children":[{"name":"GA.6.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"S":["T250I","K478R"]},"labels":{"aa":"S: T250I, K478R","spike_mutations":"T250I, K478R"}}},{"name":"GA.6","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000192","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"ORF1a":["I1551V"]},"labels":{"aa":"ORF1a: I1551V"}}},{"name":"GA.8.1","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.96117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF1b":["A2168V"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"]},"labels":{"aa":"M: H125Y; ORF1b: A2168V; ORF8: C102F; S: K182E, S494P, E554K","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}},"children":[{"name":"GA.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000194","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80721"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"ORF1a":["M85-"],"S":["N450D","K478R"]},"labels":{"aa":"ORF1a: M85-; S: N450D, K478R","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000195","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"ORF1a":["E622G","T1429I"]},"labels":{"aa":"ORF1a: E622G, T1429I"}},"children":[{"name":"GA.7.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}},{"name":"GA.7.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.90647"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000196","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"ORF1a":["N1080D","S2553F"],"S":["K356T"]},"labels":{"aa":"ORF1a: N1080D, S2553F; S: K356T","spike_mutations":"K356T"}},"children":[{"name":"GA.4","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.2","node_attrs":{"div":105,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"ORF1b":["P2313S"],"S":["K558N","G1124S"]},"labels":{"aa":"ORF1b: P2313S; S: K558N, G1124S","spike_mutations":"K558N, G1124S"}}},{"name":"NODE_0000197","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":109,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"ORF1b":["E1184D"],"S":["F186L","L585F"]},"labels":{"aa":"ORF1b: E1184D; S: F186L, L585F","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000198","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":108,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":109,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.2","node_attrs":{"div":113,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF1a":["G519S"],"ORF6":["E13Q"],"S":["T572I"]},"labels":{"aa":"ORF1a: G519S; ORF6: E13Q; S: T572I","spike_mutations":"T572I"}}},{"name":"GA.4.1.3","node_attrs":{"div":112,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"GA.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"ORF1a":["V1339I"]},"labels":{"aa":"N: K370N; ORF1a: V1339I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":92,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":92,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7953476905822754}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.110"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.110"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.232283592224121}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"ORF1a":["T4129I"]},"labels":{"aa":"ORF1a: T4129I"}}},{"name":"XBB.1.5.22","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"ORF1a":["E1498A"],"S":["Q146K"]},"labels":{"aa":"ORF1a: E1498A; S: Q146K","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.23","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"ORF1a":["P4220L"]},"labels":{"aa":"ORF1a: P4220L"}}},{"name":"XBB.1.5.43","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.43"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.45","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.45"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.57","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.57"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.58"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF1b":["V1607I"],"ORF6":["D6G"],"S":["Q146K","S704L"]},"labels":{"aa":"ORF1b: V1607I; ORF6: D6G; S: Q146K, S704L","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.87"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"ORF1a":["M1588K","E1633K"],"S":["K478T"]},"labels":{"aa":"ORF1a: M1588K, E1633K; S: K478T","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8739418983459473}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.062387466430664}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8739418983459473}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":93,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.2760300636291504}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.755798816680908}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"ORF1b":["A1643V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1643V; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.101"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.101"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.707679271697998}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.104"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.104"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.082747936248779}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.105"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.105"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"ORF1a":["S911F"],"ORF1b":["Y1176H","V2178I"],"S":["K304N"]},"labels":{"aa":"ORF1a: S911F; ORF1b: Y1176H, V2178I; S: K304N","spike_mutations":"K304N"}}},{"name":"XBB.1.5.108","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.108"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.108"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","T22930A","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF1b":["A1547S"],"ORF9b":["V30M"],"S":["K304N","F456L"]},"labels":{"aa":"N: G30-, -33D; ORF1b: A1547S; ORF9b: V30M; S: K304N, F456L","spike_mutations":"K304N, F456L"}}},{"name":"XBB.1.5.109","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.109"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.109"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"ORF1a":["T654A"],"S":["F456L"]},"labels":{"aa":"ORF1a: T654A; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.11","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.960801124572754}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"ORF1a":["G401S"]},"labels":{"aa":"ORF1a: G401S"}}},{"name":"XBB.1.5.12","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.64321231842041}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.18","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.734973192214966}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"ORF1a":["T2300I"]},"labels":{"aa":"ORF1a: T2300I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.002401351928711}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8424923419952393}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.29","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.41404999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"ORF1a":["L3808F"],"ORF1b":["S2312L","A2431V"],"S":["A348V"]},"labels":{"aa":"ORF1a: L3808F; ORF1b: S2312L, A2431V; S: A348V","spike_mutations":"A348V"}}},{"name":"XBB.1.5.31","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.887559652328491}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.34","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.28225564956665}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"ORF1a":["T1754I"]},"labels":{"aa":"ORF1a: T1754I"}}},{"name":"XBB.1.5.33","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.639432430267334}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.35","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.06293249130249}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.36","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.254280090332031}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.95377"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184874534606934}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.52","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.52"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.847869634628296}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.54"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.51","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.51"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.948946714401245}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF1a":["D3009A"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1a: D3009A; ORF3a: A54V"}}},{"name":"XBB.1.5.59","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.59"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.106780052185059}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"ORF1a":["S2822P"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2822P; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.62"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.189829349517822}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.63"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7503247261047363}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.64"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.169807434082031}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.67"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.767808198928833}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.66"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8009426593780518}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}},{"name":"XBB.1.5.69","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.69"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.266829013824463}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"ORF1a":["V2943I"]},"labels":{"aa":"ORF1a: V2943I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.75"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.355569362640381}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.79"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.65611457824707}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.80"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.27465295791626}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.91194"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.82"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0449196302129404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.85","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.85"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9143218994140625}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.97"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.97"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439690589904785}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.98","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.98"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.98"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.99","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.99"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.99"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.526114463806152}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"ORF1a":["V1122A","T2121I"]},"labels":{"aa":"ORF1a: V1122A, T2121I"}}},{"name":"NODE_0000202","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.174046039581299}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-21"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.359072208404541}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"ORF1b":["V248F"]},"labels":{"aa":"ORF1b: V248F"}},"children":[{"name":"EM.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.395593643188477}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6628339290618896}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762267112731934}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"ORF1a":["T403I"],"S":["I666V"]},"labels":{"aa":"ORF1a: T403I; S: I666V","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.809103012084961}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.762267112731934}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.943019390106201}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.9225876331329346}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000206","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.29094"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1023732112409157"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.41123000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.109566688537598}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"ORF1a":["T1168I"]},"labels":{"aa":"ORF1a: T1168I"}},"children":[{"name":"HQ.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.92"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.92"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.738426208496094}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.282760143280029}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.100"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.100"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.495176315307617}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7288198471069336}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850557327270508}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-29"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7288198471069336}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9712748527526855}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"ORF1b":["L1681F"],"S":["F456L"]},"labels":{"aa":"ORF1b: L1681F; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.107"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.107"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.522456645965576}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF1a":["T3696A"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"]},"labels":{"aa":"N: A155V; ORF1a: T3696A; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.994798421859741}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.399629592895508}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.50"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"ORF1a":["A2097V"],"S":["P621S"]},"labels":{"aa":"N: T49I; ORF1a: A2097V; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.48403999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.71"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.380539417266846}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["V511I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: V511I","spike_mutations":"V511I"}}}]},{"name":"NODE_0000213","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"ORF1a":["K322R"]},"labels":{"aa":"ORF1a: K322R"}},"children":[{"name":"GC.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9061"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.03073601411565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.989252090454102}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"ORF1a":["F4342L"],"S":["T323I"]},"labels":{"aa":"ORF1a: F4342L; S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.277385234832764}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000214","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2972187995910645}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"ORF1a":["G2868S"]},"labels":{"aa":"ORF1a: G2868S"}},"children":[{"name":"XBB.1.5.86","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.2972187995910645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000215","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.86"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.091251373291016}},"branch_attrs":{"mutations":{"nuc":["A11399G"],"ORF1a":["M3712V"]},"labels":{"aa":"ORF1a: M3712V"}},"children":[{"name":"HA.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"HA.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.86.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}}}]}]},{"name":"NODE_0000216","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.93"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.033751010894775}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000217","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"ORF1a":["T2280N"],"S":["T346I"]},"labels":{"aa":"ORF1a: T2280N; S: T346I","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.7416800000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.73864"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"ORF1a":["T3356I"]},"labels":{"aa":"ORF1a: T3356I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.262170791625977}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"ORF1a":["A1851V"]},"labels":{"aa":"ORF1a: A1851V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.95"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.288366317749023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.83075475692749}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.99921178817749}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.1186099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF1a":["P309S"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"]},"labels":{"aa":"ORF1a: P309S; ORF3a: A31V, T269M; S: T284I, R403K, L513F","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.693548202514648}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.511922359466553}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000223","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.372507095336914}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000224","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{}}},{"name":"FZ.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0000225","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"ORF1a":["I3693T"]},"labels":{"aa":"ORF1a: I3693T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000226","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"HZ.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.68.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"ORF1a":["H3580Y"]},"labels":{"aa":"ORF1a: H3580Y"}}}]}]},{"name":"NODE_0000227","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"ORF1a":["P1862S","T3775A"],"S":["Q146P","P631S"]},"labels":{"aa":"ORF1a: P1862S, T3775A; S: Q146P, P631S","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000228","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"ORF1a":["G1073V"]},"labels":{"aa":"ORF1a: G1073V"}},"children":[{"name":"HC.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HC.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.44.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"ORF1a":["A1352V","E1858K"],"S":["D1084H"]},"labels":{"aa":"ORF1a: A1352V, E1858K; S: D1084H","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000229","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5768063068389893}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.3","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"EK.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9873000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.0346353162114479"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["M85-"],"S":["N417S"]},"labels":{"aa":"ORF1a: M85-; S: N417S","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.174569606781006}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.5.13","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.5768063068389893}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"ORF1a":["L3829F"],"S":["T259I"]},"labels":{"aa":"ORF1a: L3829F; S: T259I","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000231","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{"nuc":["C920T"]}},"children":[{"name":"XBB.1.5.26","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.580750465393066}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{"nuc":["C21910A","C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"EU.1","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9577000000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.103054523468018}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000233","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}},{"name":"EU.1.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.3","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"EU.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.5237400000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9548847118984406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}}]}]}]},{"name":"NODE_0000234","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.345157623291016}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.842705726623535}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"ORF1a":["Q3966L"]},"labels":{"aa":"ORF1a: Q3966L"}}},{"name":"GN.5","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"ORF1a":["L1110I","S4135F"]},"labels":{"aa":"ORF1a: L1110I, S4135F"}}},{"name":"XBB.1.5.73","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.345157623291016}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000235","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.668501853942871}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF1a":["T3356I"],"ORF3a":["G18V"]},"labels":{"aa":"ORF1a: T3356I; ORF3a: G18V"}},"children":[{"name":"GN.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000236","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"ORF1b":["A1643V"]},"labels":{"aa":"ORF1b: A1643V"}}},{"name":"GN.1","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.347914218902588}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.3","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"ORF1a":["P4211T"],"S":["L455F"]},"labels":{"aa":"ORF1a: P4211T; S: L455F","spike_mutations":"L455F"}}},{"name":"GN.1.2","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.4","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.102"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.851889610290527}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"ORF1b":["H2388Y"]},"labels":{"aa":"ORF1b: H2388Y"}},"children":[{"name":"JD.2","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"ORF1a":["G519S"],"S":["E554K"]},"labels":{"aa":"ORF1a: G519S; S: E554K","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.6221184730529785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000240","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}},{"name":"JD.1.2.1","node_attrs":{"div":114,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF1b":["D1656E"],"ORF8":["A65V"],"S":["E554Q"]},"labels":{"aa":"N: P365L; ORF1b: D1656E; ORF8: A65V; S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0000241","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"ORF1b":["A241V"],"S":["A475V"]},"labels":{"aa":"ORF1b: A241V; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.9703145027160645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000242","node_attrs":{"div":104,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.197514057159424}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000243","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"ORF1a":["N1094K"]},"labels":{"aa":"ORF1a: N1094K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":108,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"ORF1a":["D1940G"],"S":["D1153H"]},"labels":{"aa":"ORF1a: D1940G; S: D1153H","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.20635"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2868306565498102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000244","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.328376531600952}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.1","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.2","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.4","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.3","node_attrs":{"div":108,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.1261900000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3046787170970133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-04"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF1a":["V1584M"],"ORF6":["N28D"],"S":["T470N"]},"labels":{"aa":"ORF1a: V1584M; ORF6: N28D; S: T470N","spike_mutations":"T470N"}}},{"name":"JD.1.1.7","node_attrs":{"div":106,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"ORF1b":["R2257S"]},"labels":{"aa":"ORF1b: R2257S"}}},{"name":"JD.1.1.5","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"JD.1.1.6","node_attrs":{"div":107,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JD.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}}]}]}]}]}]},{"name":"internal_db2d2241","node_attrs":{"div":103,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF1a":["A4068S"],"ORF8":["P38S"],"S":["L455F","F456L"]},"labels":{"aa":"ORF1a: A4068S; ORF8: P38S; S: L455F, F456L","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"ORF1b":["D1028G"],"S":["E554G"]},"labels":{"aa":"ORF1b: D1028G; S: E554G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.7","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.6","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.9","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":103,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000246","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"ORF1b":["T792I"],"S":["E180K"]},"labels":{"aa":"ORF1b: T792I; S: E180K","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.8.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"ORF1a":["N1555S","I2010V"],"S":["N185I","A475V"]},"labels":{"aa":"ORF1a: N1555S, I2010V; S: N185I, A475V","spike_mutations":"N185I, A475V"}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"ORF1a":["T2859I"],"ORF1b":["T310I"],"S":["A475V"]},"labels":{"aa":"ORF1a: T2859I; ORF1b: T310I; S: A475V","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"ORF1a":["A876S"]},"labels":{"aa":"ORF1a: A876S"}},"children":[{"name":"GK.3","node_attrs":{"div":105,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"GK.3.1","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"NODE_0000250","node_attrs":{"div":104,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.4253100000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"ORF1a":["A2710T","M3129I","P3134S"],"S":["T76I","N450D"]},"labels":{"aa":"ORF1a: A2710T, M3129I, P3134S; S: T76I, N450D","spike_mutations":"T76I, N450D"}}},{"name":"internal_a33b4516","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.3","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.2","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2.4","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.8981300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4069020708463185"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"ORF1a":["L624I","L3641S"],"ORF1b":["S763C"]},"labels":{"aa":"ORF1a: L624I, L3641S; ORF1b: S763C"}},"children":[{"name":"GK.2.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.89509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000253","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":106,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"ORF1a":["R287G","E633A"],"ORF1b":["D1130G"]},"labels":{"aa":"ORF1a: R287G, E633A; ORF1b: D1130G"}}},{"name":"GK.1.5","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"ORF1a":["T1597I"],"S":["F186L"]},"labels":{"aa":"ORF1a: T1597I; S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.4","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"ORF1a":["A2379V"],"S":["S98F","K478R"]},"labels":{"aa":"ORF1a: A2379V; S: S98F, K478R","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.7","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.1.1","node_attrs":{"div":109,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"ORF1a":["P309L"],"S":["A475V"]},"labels":{"aa":"ORF1a: P309L; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":110,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"ORF1a":["M2374L"],"ORF1b":["G1789S"],"S":["I68V"]},"labels":{"aa":"ORF1a: M2374L; ORF1b: G1789S; S: I68V","spike_mutations":"I68V"}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":107,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":118,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"ORF1a":["D147G","D2592Y","V2715I","T4175I"],"ORF1b":["N1426K"],"S":["A475V"]},"labels":{"aa":"ORF1a: D147G, D2592Y, V2715I, T4175I; ORF1b: N1426K; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6","node_attrs":{"div":108,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.6.1","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"ORF1a":["I114V"],"S":["A475V"]},"labels":{"aa":"ORF1a: I114V; S: A475V","spike_mutations":"A475V"}}}]},{"name":"internal_34743931","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"ORF1a":["L16F","G2207S","S2214L"],"S":["A475V","E554K"]},"labels":{"aa":"ORF1a: L16F, G2207S, S2214L; S: A475V, E554K","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":119,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF1a":["P2046S"],"ORF3a":["R134H"],"S":["K187I","A222P"]},"labels":{"aa":"ORF1a: P2046S; ORF3a: R134H; S: K187I, A222P","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000259","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF1a":["I573V","T4129I"],"ORF8":["A65V"],"ORF9b":["T95M"]},"labels":{"aa":"ORF1a: I573V, T4129I; ORF8: A65V; ORF9b: T95M"}},"children":[{"name":"GK.1.10","node_attrs":{"div":111,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000260","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":113,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"GK.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000261","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"clade_membership":{"value":"23G"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1.1","node_attrs":{"div":118,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.1446400000000003"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3541583181563797"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"ORF1a":["T1754I"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: T1754I; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"KN.1","node_attrs":{"div":114,"clade_display":{"value":"23G (XBB.1.5.70)"},"Nextclade_pango":{"value":"KN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23G"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000262","node_attrs":{"div":94,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-2.4131407737731934}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.106"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.106"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.205327987670898}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"ORF1a":["V28I","R3542H"],"S":["A623V"]},"labels":{"aa":"ORF1a: V28I, R3542H; S: A623V","spike_mutations":"A623V"}}},{"name":"XBB.1.5.19","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0622477531433105}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"ORF1b":["R172C"]},"labels":{"aa":"ORF1b: R172C"}}},{"name":"XBB.1.5.20","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.6764075756073}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.25","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-18"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.187679767608643}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.515899181365967}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"ORF1a":["E1015G"],"S":["K478R"]},"labels":{"aa":"ORF1a: E1015G; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.674118757247925}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"ORF1a":["T2823I"]},"labels":{"aa":"ORF1a: T2823I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.537867546081543}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0984206199646}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"ORF1a":["S2246L"],"S":["K1181I"]},"labels":{"aa":"ORF1a: S2246L; S: K1181I","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.56"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.201076984405518}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.60"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.624792575836182}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"ORF1a":["T2106I"],"S":["M177I"]},"labels":{"aa":"ORF1a: T2106I; S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.540179252624512}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.61"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.265189170837402}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.65"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8305227756500244}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.74","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9630099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.74"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0169257119491577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF1b":["V728I"],"ORF8":["T11I"],"S":["K462R"]},"labels":{"aa":"ORF1b: V728I; ORF8: T11I; S: K462R","spike_mutations":"K462R"}}},{"name":"XBB.1.5.72","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.72"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"ORF1a":["G445S"],"S":["F456L"]},"labels":{"aa":"ORF1a: G445S; S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.1.5.78","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.78"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.389549255371094}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"ORF1a":["N460D"]},"labels":{"aa":"ORF1a: N460D"}}},{"name":"XBB.1.5.76","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.76"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.102418422698975}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"ORF1a":["T3696A"]},"labels":{"aa":"ORF1a: T3696A"}}},{"name":"XBB.1.5.8","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.449069023132324}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.81","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.81"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.6281256675720215}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.83","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.83"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.545154094696045}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.84"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.84"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.25019645690918}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.88","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.88"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.88"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.298462867736816}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.15329647064209}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.89","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.89"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.89"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF1a":["L2869F"],"ORF7a":["T120I"],"S":["K478R","E554A"]},"labels":{"aa":"ORF1a: L2869F; ORF7a: T120I; S: K478R, E554A","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.91","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.91"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.91"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.224147796630859}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.90"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.90"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"ORF1b":["S2312L"],"S":["P621S"]},"labels":{"aa":"ORF1b: S2312L; S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.96","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.96"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.96"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.1118998527526855}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"XBB.1.5.94","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.94"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.94"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"NODE_0000263","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.7865633964538574}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000264","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.83085"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.42"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"ORF1b":["V1706I"],"S":["P521T","V772I"]},"labels":{"aa":"ORF1b: V1706I; S: P521T, V772I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.83156"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9838451476656441"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.93473"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.41"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9544161880958891"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.13517951965332}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.48"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.185689926147461}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000267","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF1a":["T1437I"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"]},"labels":{"aa":"ORF1a: T1437I; ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"KA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.103"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.103"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.166012763977051}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.9350799999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.958531820556306"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"GB.2","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"GB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"ORF1a":["R1464Q","A2636T"],"S":["K478R"]},"labels":{"aa":"ORF1a: R1464Q, A2636T; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.46","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.46"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-23"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.184237480163574}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.0942840576171875}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000270","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF1a":["G519S","V3367I","T4090I"],"ORF9b":["T95M"],"S":["K478R"]},"labels":{"aa":"N: I292V; ORF1a: G519S, V3367I, T4090I; ORF9b: T95M; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HR.1","node_attrs":{"div":105,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"HR.1.1","node_attrs":{"div":110,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"ORF1a":["A1049V","D2980N"],"S":["K304N"]},"labels":{"aa":"ORF1a: A1049V, D2980N; S: K304N","spike_mutations":"K304N"}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.816847085952759}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.2","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.310755729675293}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"HT.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"HT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.592963218688965}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"XBB.1.5.49","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.49"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-25"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.816847085952759}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000272","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":99,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000273","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1.1","node_attrs":{"div":109,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF1a":["H2092Y"],"ORF3a":["I63T"]},"labels":{"aa":"N: S26C; ORF1a: H2092Y; ORF3a: I63T"}}},{"name":"JB.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.74111"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000274","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2.1","node_attrs":{"div":103,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}},{"name":"JB.2","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"JB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.5945"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.53.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0935452141087265"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"ORF1a":["M3684T"]},"labels":{"aa":"ORF1a: M3684T"}},"children":[{"name":"FT.4","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}},"children":[{"name":"FT.1","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"FT.2","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}}]},{"name":"internal_747c613f","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":101,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FT.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.74638"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0924169334128189"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"NODE_0000279","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.89299"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0707606743218023"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":95,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"XBB.1.5.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.8008432388305664}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF1a":["A1473V"],"ORF7a":["P99L"],"ORF7b":["E3*"]},"labels":{"aa":"ORF1a: A1473V; ORF7a: P99L; ORF7b: E3*"}},"children":[{"name":"FD.1.1","node_attrs":{"div":102,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"ORF1a":["T4174I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T4174I; S: F456L","spike_mutations":"F456L"}}},{"name":"FD.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"ORF1a":["G519S"],"S":["Q146K"]},"labels":{"aa":"ORF1a: G519S; S: Q146K","spike_mutations":"Q146K"}},"children":[{"name":"FD.2.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-01"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"ORF1a":["D3022N"]},"labels":{"aa":"ORF1a: D3022N"}}},{"name":"FD.2","node_attrs":{"div":97,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-27"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-3.945685386657715}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"ORF1a":["L4191F"]},"labels":{"aa":"ORF1a: L4191F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":98,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"ORF1a":["T4355I"],"ORF1b":["I2634F"]},"labels":{"aa":"ORF1a: T4355I; ORF1b: I2634F"}}},{"name":"FD.4","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000283","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"clade_membership":{"value":"23A"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["C29580T"]}},"children":[{"name":"FD.5","node_attrs":{"div":96,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":100,"clade_display":{"value":"23A (XBB.1.5)"},"Nextclade_pango":{"value":"FD.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23A"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]}]}]}]}]},{"name":"NODE_0000284","node_attrs":{"div":91,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.78204870223999}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":93,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.561348915100098}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.214216709136963}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.214216709136963}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"ORF1a":["P3504L"],"ORF1b":["H1838N"]},"labels":{"aa":"ORF1a: P3504L; ORF1b: H1838N"}}},{"name":"NODE_0000286","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"HU.2","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF1a":["R24H"],"ORF1b":["A1428V"],"ORF3a":["Q245R"],"S":["T76I"]},"labels":{"aa":"ORF1a: R24H; ORF1b: A1428V; ORF3a: Q245R; S: T76I","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000287","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.86018"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.950188045949472"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.67693"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9788766097021935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"ORF1a":["D220E","C667Y"],"S":["Q675K"]},"labels":{"aa":"ORF1a: D220E, C667Y; S: Q675K","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.547652721405029}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"ORF1b":["S997P"],"S":["I197T"]},"labels":{"aa":"ORF1b: S997P; S: I197T","spike_mutations":"I197T"}},"children":[{"name":"FY.2.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"ORF1a":["T1874I"],"S":["A684V"]},"labels":{"aa":"ORF1a: T1874I; S: A684V","spike_mutations":"A684V"}}},{"name":"FY.2","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_87efaafa","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"ORF1a":["A591V"]},"labels":{"aa":"ORF1a: A591V"}},"children":[{"name":"FY.6","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.388861656188965}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":102,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF1a":["T1079S"],"ORF7b":["A15S"],"S":["S939F"]},"labels":{"aa":"ORF1a: T1079S; ORF7b: A15S; S: S939F","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF1a":["A3143V"],"ORF3a":["A103T"]},"labels":{"aa":"ORF1a: A3143V; ORF3a: A103T"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"ORF1b":["P1682S"],"S":["K478R"]},"labels":{"aa":"ORF1b: P1682S; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.8.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8926499999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"ORF1b":["V1149L"],"S":["P521Q"]},"labels":{"aa":"ORF1b: V1149L; S: P521Q","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"ORF1a":["E750K"]},"labels":{"aa":"ORF1a: E750K"}},"children":[{"name":"FY.3","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.611515045166016}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"ORF1a":["E3764G"]},"labels":{"aa":"ORF1a: E3764G"}}},{"name":"FY.3.3","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}},{"name":"FY.3.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-3.860802173614502}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"ORF1a":["D1282Y","T1760I"],"S":["I210T"]},"labels":{"aa":"ORF1a: D1282Y, T1760I; S: I210T","spike_mutations":"I210T"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.80106"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9530703986942458"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"ORF1a":["Y2171F"],"ORF1b":["V2287I"]},"labels":{"aa":"ORF1a: Y2171F; ORF1b: V2287I"}}},{"name":"NODE_0000297","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.74983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9828941175755879"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-06"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"ORF1a":["S2926F"]},"labels":{"aa":"ORF1a: S2926F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"ORF1a":["L1683I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1683I; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"ORF1a":["V4350I"],"S":["M153I","F186S","S247N"]},"labels":{"aa":"ORF1a: V4350I; S: M153I, F186S, S247N","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"ORF1a":["D3009N","Y4077C"],"S":["T572I"]},"labels":{"aa":"ORF1a: D3009N, Y4077C; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"ORF1a":["M2796I"]},"labels":{"aa":"ORF1a: M2796I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":100,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.5.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3936004638671875}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"ORF1b":["D1782N"]},"labels":{"aa":"ORF1b: D1782N"}},"children":[{"name":"FY.1","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.3936004638671875}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":106,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-16"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"ORF1b":["T1655I"],"S":["I569T"]},"labels":{"aa":"ORF1b: T1655I; S: I569T","spike_mutations":"I569T"}}}]},{"name":"internal_6436aedc","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"ORF1b":["P218L"],"S":["T572I"]},"labels":{"aa":"ORF1b: P218L; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2.1","node_attrs":{"div":103,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"ORF1a":["T1597I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T1597I; S: W64L","spike_mutations":"W64L"}}},{"name":"FY.1.2","node_attrs":{"div":98,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000305","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":101,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":104,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"FY.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000306","node_attrs":{"div":101,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.99566912651062}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF1a":["L3829F"],"ORF1b":["D1746Y"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"]},"labels":{"aa":"ORF1a: L3829F; ORF1b: D1746Y; ORF9b: N55S; S: E180V, K478R, S486P","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":101,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-2.99566912651062}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.181058645248413}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.10","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.21321964263916}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.14","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.7388600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0744467131509066"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.19","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}},{"name":"XBB.1.16.21","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"ORF1a":["V4072I"]},"labels":{"aa":"ORF1a: V4072I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.22","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.469313144683838}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.23","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.3506975173950195}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.25","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"ORF1a":["K510E"]},"labels":{"aa":"ORF1a: K510E"}}},{"name":"XBB.1.16.24","node_attrs":{"div":111,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"ORF1a":["P748L","E972K"],"S":["K182E","P521T","V551I","E554K"]},"labels":{"aa":"ORF1a: P748L, E972K; S: K182E, P521T, V551I, E554K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.26","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.182722091674805}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.27","node_attrs":{"div":116,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF1a":["G963D","K2045R","A3889T"],"ORF3a":["M260T"],"S":["F456L","E554K"]},"labels":{"aa":"ORF1a: G963D, K2045R, A3889T; ORF3a: M260T; S: F456L, E554K","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.28","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"ORF1a":["S994N"],"S":["Q613H","Q675K","V1230A"]},"labels":{"aa":"ORF1a: S994N; S: Q613H, Q675K, V1230A","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.3","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-05"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.5","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.220454692840576}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.7","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-25"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"ORF1a":["Y1090H"],"S":["T732I"]},"labels":{"aa":"ORF1a: Y1090H; S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-26"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.036107540130615}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"ORF1a":["S2500F"],"S":["F456L"]},"labels":{"aa":"ORF1a: S2500F; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000307","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":114,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"KJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF1a":["P1659L"],"ORF8":["F3L"],"S":["T573I"]},"labels":{"aa":"ORF1a: P1659L; ORF8: F3L; S: T573I","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.64385"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.961172580718994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000308","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.1","node_attrs":{"div":110,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"ORF1a":["M598I"],"S":["Q52H"]},"labels":{"aa":"ORF1a: M598I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"JM.2","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-22"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"XBB.1.16.15","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000309","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.326810836791992}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"ORF1a":["L3606F"],"ORF1b":["Y1746D"],"S":["T883I"]},"labels":{"aa":"ORF1a: L3606F; ORF1b: Y1746D; S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"ORF1a":["G519S","G1101D"]},"labels":{"aa":"ORF1a: G519S, G1101D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.1","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"ORF1a":["T2121I"],"ORF1b":["A176V","V1228L"],"S":["H1101Y"]},"labels":{"aa":"N: A35T; ORF1a: T2121I; ORF1b: A176V, V1228L; S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"HF.1.2","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"ORF1a":["P1158S"],"S":["A688V"]},"labels":{"aa":"ORF1a: P1158S; S: A688V","spike_mutations":"A688V"}}},{"name":"HF.1","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"HF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9202957153320312}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_adf0d069","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.265481472015381}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000313","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.1121835708618164}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.2","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF1a":["E237D"],"ORF8":["Q91H"],"S":["Q675H"]},"labels":{"aa":"ORF1a: E237D; ORF8: Q91H; S: Q675H","spike_mutations":"Q675H"}}},{"name":"JF.3","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"ORF1a":["H417Y","D4165G"],"S":["Q14H","L455F","S810L"]},"labels":{"aa":"ORF1a: H417Y, D4165G; S: Q14H, L455F, S810L","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.4","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF1a":["S212L"],"ORF8":["A15V"]},"labels":{"aa":"ORF1a: S212L; ORF8: A15V"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.236754417419434}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000315","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}},"children":[{"name":"JF.1.1.2","node_attrs":{"div":110,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1.1","node_attrs":{"div":112,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF1a":["P2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: P2005S; S: A475V","spike_mutations":"A475V"}}},{"name":"JF.1.1","node_attrs":{"div":109,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"JF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"2.14642"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0306074934635072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-11"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"ORF1a":["R542C"],"S":["K97E"]},"labels":{"aa":"ORF1a: R542C; S: K97E","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":102,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"ORF1a":["T2106N"],"S":["E619Q"]},"labels":{"aa":"ORF1a: T2106N; S: E619Q","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}},{"name":"FU.3.1","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}}]},{"name":"NODE_0000319","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000320","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FU.1.1.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"FU.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"ORF1a":["A1679V"],"S":["N74S"]},"labels":{"aa":"ORF1a: A1679V; S: N74S","spike_mutations":"N74S"}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF1a":["P926H"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1a: P926H; ORF3a: V13L"}},"children":[{"name":"GY.4","node_attrs":{"div":106,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8164899999999998"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.3","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.5","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"ORF1a":["V1765I"]},"labels":{"aa":"ORF1a: V1765I"}}},{"name":"GY.8","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.7","node_attrs":{"div":107,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"ORF1a":["G3617C"]},"labels":{"aa":"ORF1a: G3617C"}}},{"name":"GY.9","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.012419700622559}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":103,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"XBB.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2","node_attrs":{"div":104,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"GY.2.1","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]},{"name":"internal_4bba6217","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"ORF1a":["A4068S"],"S":["L84I"]},"labels":{"aa":"ORF1a: A4068S; S: L84I","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":105,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000324","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"clade_membership":{"value":"23B"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":108,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":115,"clade_display":{"value":"23B (XBB.1.16)"},"Nextclade_pango":{"value":"GY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23B"},"ace2_binding":{"value":"-1.2326700000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2814666878404952"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"ORF1a":["P276S","T951I","V1063I"],"S":["A475V"]},"labels":{"aa":"ORF1a: P276S, T951I, V1063I; S: A475V","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":92,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.0967888832092285}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":94,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000326","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42.1","node_attrs":{"div":96,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-17"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.42","node_attrs":{"div":95,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.806872367858887}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000327","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_membership":{"value":"22F"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":99,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"HL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"ORF1a":["P1950H"],"S":["S929N"]},"labels":{"aa":"ORF1a: P1950H; S: S929N","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":97,"clade_display":{"value":"22F (XBB)"},"Nextclade_pango":{"value":"XBB.1.42.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22F"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.42.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":93,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"ORF1a":["G1819S"]},"labels":{"aa":"ORF1a: G1819S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":93,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.211965560913086}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":94,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.6","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.13558"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0724478315077164"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF1a":["A967V"],"ORF1b":["T577A"],"ORF7b":["H42Q"],"S":["R403K","A570T"]},"labels":{"aa":"ORF1a: A967V; ORF1b: T577A; ORF7b: H42Q; S: R403K, A570T","spike_mutations":"R403K, A570T"}}},{"name":"XBB.1.9.7","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"ORF1a":["P1018T","P2079S"],"S":["K478R","S486P"]},"labels":{"aa":"ORF1a: P1018T, P2079S; S: K478R, S486P","spike_mutations":"K478R, S486P"}}},{"name":"XBB.1.9.5","node_attrs":{"div":94,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"ORF1a":["D629E"]},"labels":{"aa":"ORF1a: D629E"}}},{"name":"NODE_0000329","node_attrs":{"div":95,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"ORF1b":["G1568C","G2005S"]},"labels":{"aa":"ORF1b: G1568C, G2005S"}},"children":[{"name":"GD.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.068892478942871}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.6875"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0109791747614623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.331241607666016}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"GD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"ORF1a":["I4127V"],"S":["F59L"]},"labels":{"aa":"ORF1a: I4127V; S: F59L","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":95,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.40686999999999995"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.036272048950195}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000330","node_attrs":{"div":96,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927204608917236}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.11","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF1a":["L349F"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: L349F; ORF9b: T60I"}}},{"name":"FL.12","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-08"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.064053058624268}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"ORF1a":["C2210F"]},"labels":{"aa":"ORF1a: C2210F"}}},{"name":"FL.14","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.2342681884765625}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.22","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.30185604095459}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1b: I1416V"}}},{"name":"FL.25","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.532744884490967}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.29","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.7904599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.65922737121582}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"ORF1b":["I2331V"],"S":["S490P"]},"labels":{"aa":"ORF1b: I2331V; S: S490P","spike_mutations":"S490P"}}},{"name":"FL.27","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.406278133392334}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"ORF1a":["V3747I"]},"labels":{"aa":"ORF1a: V3747I"}}},{"name":"FL.28","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF1a":["S1520F"],"ORF3a":["R68I"],"S":["K478R"]},"labels":{"aa":"ORF1a: S1520F; ORF3a: R68I; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.34","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.36"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"ORF1a":["V3925I"],"S":["R190S","K356T","T572I","A899S","A1070T"]},"labels":{"aa":"ORF1a: V3925I; S: R190S, K356T, T572I, A899S, A1070T","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.37"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.926265239715576}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.40"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.2174906730651855}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"FL.6","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-03"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.93975305557251}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"ORF1a":["I849V"]},"labels":{"aa":"ORF1a: I849V"}}},{"name":"FL.7","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.511373519897461}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.413914680480957}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"FL.8","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.164649486541748}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"XBB.1.9.1","node_attrs":{"div":96,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.3927204608917236}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000331","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}},{"name":"FL.19.1","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"ORF1b":["A1877V"],"S":["F456L"]},"labels":{"aa":"ORF1b: A1877V; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF1b":["I539V"],"ORF3a":["N82S"],"S":["Q613H","A688V"]},"labels":{"aa":"ORF1b: I539V; ORF3a: N82S; S: Q613H, A688V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.24","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4590277671813965}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0848"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9957660361777405"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF1a":["E1196V"],"ORF3a":["T89I"],"S":["Q493L"]},"labels":{"aa":"ORF1a: E1196V; ORF3a: T89I; S: Q493L","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000334","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"ORF1a":["A79T"],"S":["A484K"]},"labels":{"aa":"ORF1a: A79T; S: A484K","spike_mutations":"A484K"}},"children":[{"name":"FL.30","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"ORF1b":["P1427H","P2313L"]},"labels":{"aa":"ORF1b: P1427H, P2313L"}}},{"name":"FL.30.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.30.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.90046"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.020189608544247"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}}]},{"name":"NODE_0000335","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"ORF1b":["M657I"]},"labels":{"aa":"ORF1b: M657I"}},"children":[{"name":"FL.31.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF1a":["A206V","C667Y","K1051R"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"]},"labels":{"aa":"ORF1a: A206V, C667Y, K1051R; ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H","spike_mutations":"D80H, K478R, Q613H"}}},{"name":"FL.31","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000336","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"ORF1a":["V2356I"],"S":["V6L","E554Q"]},"labels":{"aa":"ORF1a: V2356I; S: V6L, E554Q","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"ORF1b":["T2165M"],"S":["F456L"]},"labels":{"aa":"ORF1b: T2165M; S: F456L","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"ORF1b":["A1377V"]},"labels":{"aa":"ORF1b: A1377V"}},"children":[{"name":"FL.33","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.918431758880615}},"branch_attrs":{"mutations":{}}},{"name":"FL.33.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.33.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.516284465789795}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_14b9e262","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.8872175216674805}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.35.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.919839382171631}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"ORF1a":["E633K"]},"labels":{"aa":"ORF1a: E633K"}},"children":[{"name":"FL.39.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.81109"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"ORF1b":["T797I","P1427S"],"S":["K478R","P521S"]},"labels":{"aa":"ORF1b: T797I, P1427S; S: K478R, P521S","spike_mutations":"K478R, P521S"}}},{"name":"FL.39","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.39"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000340","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9747519493103027}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000341","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.17.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"ORF1a":["L681F","G2941D"],"S":["N74H"]},"labels":{"aa":"ORF1a: L681F, G2941D; S: N74H","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-14"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}}]},{"name":"NODE_0000342","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}},"children":[{"name":"FL.18","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.299053192138672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000343","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G12907A","A27507C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.18.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"ORF1a":["G519S"],"ORF1b":["H641Q"],"S":["Y200C","K478R"]},"labels":{"aa":"ORF1a: G519S; ORF1b: H641Q; S: Y200C, K478R","spike_mutations":"Y200C, K478R"}}}]}]},{"name":"NODE_0000344","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF1a":["I2010V"],"ORF3a":["L108F"],"S":["Q52H","F456L"]},"labels":{"aa":"ORF1a: I2010V; ORF3a: L108F; S: Q52H, F456L","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.5920999999999998"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.20.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.9846930503845215}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.21.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-27"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"ORF1a":["V1019F","I2873M"]},"labels":{"aa":"ORF1a: V1019F, I2873M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"ORF1a":["C657Y"]},"labels":{"aa":"ORF1a: C657Y"}},"children":[{"name":"FL.10.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.34281063079834}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.2","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.98073"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1216394663867173"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF1a":["G4178S"],"ORF1b":["N1382S"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"]},"labels":{"aa":"N: K373N, D415E; ORF1a: G4178S; ORF1b: N1382S; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N","spike_mutations":"K356T, T523N"}}},{"name":"FL.10.3","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0000347","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"ORF1b":["V1132I"]},"labels":{"aa":"ORF1b: V1132I"}},"children":[{"name":"FL.23","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.588370323181152}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"ORF1a":["A2584V"]},"labels":{"aa":"ORF1a: A2584V"}}},{"name":"NODE_0000348","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"ORF1b":["P2256S"],"S":["Q146K","S494P"]},"labels":{"aa":"ORF1b: P2256S; S: Q146K, S494P","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.96117"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9782337833287624"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.23.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8835"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9840230566620973"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000349","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.2","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"ORF1a":["T2264I"]},"labels":{"aa":"ORF1a: T2264I"}}},{"name":"FL.3.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"ORF1a":["E772K","V2998I","A4285V"]},"labels":{"aa":"ORF1a: E772K, V2998I, A4285V"}}},{"name":"FL.3.4","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.47537999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9532427062890917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"ORF1a":["P80S","T4249I"],"S":["A411S"]},"labels":{"aa":"ORF1a: P80S, T4249I; S: A411S","spike_mutations":"A411S"}}},{"name":"FL.13","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.28245210647583}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.5","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"ORF1a":["T1000I","L2527M"],"S":["F456L"]},"labels":{"aa":"ORF1a: T1000I, L2527M; S: F456L","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.952376842498779}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.2.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"totalAminoacidDeletions":{"value":35},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"ORF1a":["I1005-","V1006-","E1007-","V1008-","Q1009-","P1010-","Q1011-","L1012-","E1013-","M1014-","E1015-","L1016-","T1017-","P1018-","V1019-","V1020-","Q1021-","T1022-","I1023-","E1024-","V1025-","N1026-","T3202M"],"ORF1b":["V1110L"],"S":["D178H"]},"labels":{"aa":"ORF1a: I1005-, V1006-, E1007-, V1008-, Q1009-, P1010-, Q1011-, L1012-, E1013-, M1014-, E1015-, L1016-, T1017-, P1018-, V1019-, V1020-, Q1021-, T1022-, I1023-, E1024-, V1025-, N1026-, T3202M; ORF1b: V1110L; S: D178H","spike_mutations":"D178H"}}}]},{"name":"internal_10382b90","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"ORF1a":["P1659L"],"S":["K182E","F456L"]},"labels":{"aa":"ORF1a: P1659L; S: K182E, F456L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"ORF1a":["V2588L","F3753V"],"ORF1b":["T794S"],"S":["Q14H","A484K"]},"labels":{"aa":"ORF1a: V2588L, F3753V; ORF1b: T794S; S: Q14H, A484K","spike_mutations":"Q14H, A484K"}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"ORF1a":["M902V"],"S":["E154Q"]},"labels":{"aa":"ORF1a: M902V; S: E154Q","spike_mutations":"E154Q"}}},{"name":"FL.13.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.13.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_59305500","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.67327356338501}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"ORF1a":["E637K"]},"labels":{"aa":"ORF1a: E637K"}},"children":[{"name":"FL.38","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.38"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000355","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_24b5ee08","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"ORF1a":["G400V"]},"labels":{"aa":"ORF1a: G400V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"NODE_0000357","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"ORF1a":["S2185N"]},"labels":{"aa":"ORF1a: S2185N"}},"children":[{"name":"NODE_0000358","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","A6819G","C11747T","C29236T"],"ORF1a":["N2185S"]},"labels":{"aa":"ORF1a: N2185S"}}},{"name":"FL.15.4","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000359","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G22927T"],"ORF1a":["T2007I"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2007I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000360","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"ORF1a":["A516G","Q575H"],"ORF1b":["G2005S"],"S":["A475V"]},"labels":{"aa":"ORF1a: A516G, Q575H; ORF1b: G2005S; S: A475V","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-27"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000361","node_attrs":{"div":111,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.15.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.1","node_attrs":{"div":114,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"ORF1a":["T3506I"],"S":["P251H"]},"labels":{"aa":"ORF1a: T3506I; S: P251H","spike_mutations":"P251H"}}},{"name":"KF.2","node_attrs":{"div":113,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}}]}]}]}]}]}]}]},{"name":"NODE_0000362","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8401033878326416}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.6712799072265625}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"FL.2.6","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.4","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"internal_fc124546","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"FL.2.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"FL.2.3","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.207552909851074}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.3.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.00936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.11276678947944"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"ORF1a":["A2618T"]},"labels":{"aa":"ORF1a: A2618T"}},"children":[{"name":"FL.2.7","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.912545204162598}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.7.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.2.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-21"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"ORF1a":["V3718F"],"S":["K478R"]},"labels":{"aa":"ORF1a: V3718F; S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000366","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"FL.4","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.10","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.11","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"ORF1a":["R1170C"],"S":["D1259Y"]},"labels":{"aa":"N: T334I; ORF1a: R1170C; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"FL.4.8","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.4584245681762695}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.7751996517181396}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"ORF1a":["T951I"],"S":["V289I"]},"labels":{"aa":"ORF1a: T951I; S: V289I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.93509"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"ORF1a":["T1542I"],"S":["K478T"]},"labels":{"aa":"ORF1a: T1542I; S: K478T","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.97144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0536446089490177"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.3348299999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0393497509509053"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"ORF1a":["I2286T"],"S":["K478R"]},"labels":{"aa":"ORF1a: I2286T; S: K478R","spike_mutations":"K478R"}}},{"name":"FL.4.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.48144"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0186868047371063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000369","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.6","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}},{"name":"FL.4.5","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF1a":["D1228G"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: D1228G; ORF8: S67F"}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"ORF1a":["G993S"],"S":["A701V"]},"labels":{"aa":"ORF1a: G993S; S: A701V","spike_mutations":"A701V"}},"children":[{"name":"FL.1.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"ORF1a":["T4311I"]},"labels":{"aa":"ORF1a: T4311I"}}},{"name":"FL.1.3","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"ORF1a":["T1881I"],"ORF1b":["M606I"]},"labels":{"aa":"ORF1a: T1881I; ORF1b: M606I"}}},{"name":"FL.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.8","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.78812"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9736469561063519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"ORF1a":["P62S","T2300I","K4348R"],"S":["K478R","P521T"]},"labels":{"aa":"M: I8V; ORF1a: P62S, T2300I, K4348R; S: K478R, P521T","spike_mutations":"K478R, P521T"}}},{"name":"FL.1.7","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"internal_18deba5f","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"ORF1b":["Q2635P"]},"labels":{"aa":"ORF1b: Q2635P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-29"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"ORF1a":["S2797F"],"S":["A688S"]},"labels":{"aa":"ORF1a: S2797F; S: A688S","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-23"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.89211"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9778643306477401"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-13"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5381855964660645}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"ORF1b":["K2557R"],"S":["F456L"]},"labels":{"aa":"ORF1b: K2557R; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.5381855964660645}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000374","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.06800999999999986"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000375","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"ORF1a":["S723F","T4129I"],"S":["S490P"]},"labels":{"aa":"ORF1a: S723F, T4129I; S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KC.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}},{"name":"KC.1.1","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"KC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.15393000000000004"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1916964954726457"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}}]}]},{"name":"NODE_0000376","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"ORF1b":["S2198I"],"S":["K478R"]},"labels":{"aa":"ORF1b: S2198I; S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-06"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.5","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"HN.6","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"ORF1a":["D1933A"]},"labels":{"aa":"ORF1a: D1933A"}}},{"name":"NODE_0000377","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF1a":["T403I"],"ORF9b":["G31E"]},"labels":{"aa":"ORF1a: T403I; ORF9b: G31E"}},"children":[{"name":"HN.4.2","node_attrs":{"div":112,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"HN.4","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000378","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.1.1","node_attrs":{"div":115,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.0007299999999998658"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005141566416802"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}}]}]},{"name":"NODE_0000379","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"FL.1.5.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.1232717037200928}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.7","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.777098655700684}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"HN.8","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"ORF1a":["E2042D"]},"labels":{"aa":"ORF1a: E2042D"}}},{"name":"NODE_0000380","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"ORF1b":["P223S"]},"labels":{"aa":"ORF1b: P223S"}},"children":[{"name":"HN.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000381","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"HN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"-0.009539999999999936"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2172876260248378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"ORF1a":["G345C"],"S":["D253G"]},"labels":{"aa":"ORF1a: G345C; S: D253G","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000382","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.6197006702423096}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.12","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF1a":["T4159I"],"ORF3a":["S40L"],"S":["Q146K","E554K"]},"labels":{"aa":"N: R195T; ORF1a: T4159I; ORF3a: S40L; S: Q146K, E554K","spike_mutations":"Q146K, E554K"}}},{"name":"EG.13","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"ORF1a":["K798N"]},"labels":{"aa":"ORF1a: K798N"}}},{"name":"EG.11","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.14","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF1b":["K1383R"],"ORF3a":["A54V"]},"labels":{"aa":"ORF1b: K1383R; ORF3a: A54V"}}},{"name":"EG.7","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1186099999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0727745250647887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"ORF1a":["N2531S"],"ORF1b":["A1662V"],"S":["R403K","L513F"]},"labels":{"aa":"ORF1a: N2531S; ORF1b: A1662V; S: R403K, L513F","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"ORF1a":["S2303F"]},"labels":{"aa":"ORF1a: S2303F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":97,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.6197006702423096}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"ORF1a":["T1474I"],"ORF1b":["N969S"],"S":["R403K"]},"labels":{"aa":"ORF1a: T1474I; ORF1b: N969S; S: R403K","spike_mutations":"R403K"}},"children":[{"name":"EG.9.1","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}},{"name":"EG.9","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.20938"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}}]},{"name":"internal_16d15670","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.17686"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.0861679898367071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000385","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"ORF1a":["R24C"],"S":["S494P","A701V"]},"labels":{"aa":"ORF1a: R24C; S: S494P, A701V","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-30"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"ORF1a":["V2703L","V3683I"],"ORF1b":["P1570S"]},"labels":{"aa":"ORF1a: V2703L, V3683I; ORF1b: P1570S"}}},{"name":"EG.10.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.1256300000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1167095912810734"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000387","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.1","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.07635999999999983"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2298667334498823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"ORF1a":["P1786L"],"ORF1b":["R1576K"],"S":["L242I","A484K"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: R1576K; S: L242I, A484K","spike_mutations":"L242I, A484K"}}},{"name":"EG.6.1.2","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.6.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}}]}]},{"name":"NODE_0000388","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.3","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"ORF1a":["K322R"],"ORF1b":["I1293V"],"S":["I742V"]},"labels":{"aa":"ORF1a: K322R; ORF1b: I1293V; S: I742V","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.86275"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1352521981201698"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"ORF1a":["G2265D"],"S":["K356T"]},"labels":{"aa":"ORF1a: G2265D; S: K356T","spike_mutations":"K356T"}}},{"name":"EG.2.5","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"EG.2.2","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"ORF1a":["A702V"],"S":["K304N"]},"labels":{"aa":"N: R204P; ORF1a: A702V; S: K304N","spike_mutations":"K304N"}}},{"name":"EG.2.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.041689999999999984"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1863788114390663"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF1a":["Y1634H"],"ORF1b":["R1622I"],"ORF3a":["H243R"],"S":["V327I","F456L"]},"labels":{"aa":"ORF1a: Y1634H; ORF1b: R1622I; ORF3a: H243R; S: V327I, F456L","spike_mutations":"V327I, F456L"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.2","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.3188371658325195}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.3","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4.1","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.4","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"ORF1a":["Y1465C"],"ORF1b":["H873Y"]},"labels":{"aa":"ORF1a: Y1465C; ORF1b: H873Y"}}},{"name":"EG.4.5","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.8657900000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9677241877751146"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":98,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"ORF1a":["L2778F"]},"labels":{"aa":"ORF1a: L2778F"}}},{"name":"NODE_0000391","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":99,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.2","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.1","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"ORF1a":["T403I"],"S":["V70F","I312V"]},"labels":{"aa":"ORF1a: T403I; S: V70F, I312V","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.3","node_attrs":{"div":101,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.5","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.6","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":105,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"ORF1b":["D161G","P2321L"],"S":["S640F"]},"labels":{"aa":"ORF1b: D161G, P2321L; S: S640F","spike_mutations":"S640F"}}},{"name":"EG.1.7","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"internal_e85bc240","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"ORF1a":["S2500F"]},"labels":{"aa":"ORF1a: S2500F"}},"children":[{"name":"EG.1.4.1","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-30"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF1a":["P1921L","A2279T"],"ORF1b":["N865K"],"ORF3a":["F114V","D199E"],"S":["P217L"]},"labels":{"aa":"ORF1a: P1921L, A2279T; ORF1b: N865K; ORF3a: F114V, D199E; S: P217L","spike_mutations":"P217L"}}},{"name":"EG.1.4","node_attrs":{"div":100,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"1.0124"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.9484139900167534"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":102,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.696173667907715}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF1a":["A690V","A3143V"],"S":["F456L"]},"labels":{"aa":"ORF1a: A690V, A3143V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":103,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"internal_cc5f07eb","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":104,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.303452014923096}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.2","node_attrs":{"div":107,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"EG.5.2.3","node_attrs":{"div":106,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"NODE_0000395","node_attrs":{"div":108,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2"},"clade_membership":{"value":"23D"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF1a":["H1113Y","N2155S"],"ORF3a":["I118V"]},"labels":{"aa":"ORF1a: H1113Y, N2155S; ORF3a: I118V"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":110,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":109,"clade_display":{"value":"23D (XBB.1.9)"},"Nextclade_pango":{"value":"EG.5.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23D"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000396","node_attrs":{"div":104,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":104,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.3747880458831787}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.10","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.850918769836426}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"ORF1a":["I3758V"]},"labels":{"aa":"ORF1a: I3758V"}}},{"name":"EG.5.1.12","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.14","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.13","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.15","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.343207359313965}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"ORF1a":["T753I"]},"labels":{"aa":"ORF1a: T753I"}}},{"name":"EG.5.1.16","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"ORF1b":["A2431V"]},"labels":{"aa":"ORF1b: A2431V"}}},{"name":"EG.5.1.17","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.18","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF1a":["G3002S"],"ORF3a":["S220I"]},"labels":{"aa":"ORF1a: G3002S; ORF3a: S220I"}}},{"name":"EG.5.1.19","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.2","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"ORF1b":["V1644I"]},"labels":{"aa":"ORF1b: V1644I"}}},{"name":"EG.5.1.5","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"ORF1a":["L3293I"],"ORF1b":["T1274I","L2349V"]},"labels":{"aa":"ORF1a: L3293I; ORF1b: T1274I, L2349V"}}},{"name":"EG.5.1.7","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-25"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.31285285949707}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.9","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"ORF1a":["D982G"],"S":["L176F"]},"labels":{"aa":"ORF1a: D982G; S: L176F","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.720257520675659}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.37783145904541}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":105,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000400","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"ORF1a":["L450F"],"ORF1b":["G2510C"],"S":["L455F","K478R"]},"labels":{"aa":"ORF1a: L450F; ORF1b: G2510C; S: L455F, K478R","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"JR.1.1.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JR.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.73257"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.4312755323086508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-29"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"ORF1a":["A3061V"],"S":["K356Q"]},"labels":{"aa":"ORF1a: A3061V; S: K356Q","spike_mutations":"K356Q"}}}]}]}]},{"name":"NODE_0000401","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"NODE_0000402","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.787606239318848}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"internal_e3bca771","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"ORF1a":["R542C"]},"labels":{"aa":"ORF1a: R542C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":106,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{}}},{"name":"JG.2","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.1","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.4","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000404","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"ORF1a":["T2274I"],"S":["L455F","S704L"]},"labels":{"aa":"ORF1a: T2274I; S: L455F, S704L","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3.2","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.4253100000000001"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2837475542379917"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.8458516597747803}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF1a":["S2556L"],"ORF3a":["L140F"],"S":["T307I"]},"labels":{"aa":"ORF1a: S2556L; ORF3a: L140F; S: T307I","spike_mutations":"T307I"}}},{"name":"JG.3.4","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.5133399999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.216901623730935"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.123693943023682}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"JG.3.3","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"JG.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}}]}]},{"name":"NODE_0000405","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"ORF1a":["S1857L"],"S":["F157L"]},"labels":{"aa":"ORF1a: S1857L; S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.735767126083374}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000406","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1.10","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.025979999999999802"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.068491220474243}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.11","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.0887599999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3341105633249508"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.4","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.3","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.21974"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3005451981781486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.5","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.7","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.8","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"ORF1a":["T346I"],"S":["T208M"]},"labels":{"aa":"ORF1a: T346I; S: T208M","spike_mutations":"T208M"}}},{"name":"HV.1.9","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"internal_2378868c","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}},"children":[{"name":"HV.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.048559999999999943"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}},{"name":"HV.1.2","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.38161000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3552393372267753"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}}]},{"name":"NODE_0000408","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"ORF1a":["T1794I","P2018S"]},"labels":{"aa":"ORF1a: T1794I, P2018S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000409","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HV.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000410","node_attrs":{"div":115,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":115,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":118,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"KL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.008039999999999839"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3830518742909887"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF1b":["Q1878H"],"ORF3a":["S40P"],"S":["H1101Y"]},"labels":{"aa":"ORF1b: Q1878H; ORF3a: S40P; S: H1101Y","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000411","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"ORF1b":["D54N"]},"labels":{"aa":"ORF1b: D54N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":107,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-20"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.19","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.508697509765625}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.17","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.13706999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1972306507819483"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.14733999999999992"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2787222677331491"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.21","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.1481699999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.205901853206978"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":117,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.49366"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.310148541751831"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF1b":["R1622K"],"ORF3a":["M5I"],"S":["L452Q","L455F"]},"labels":{"aa":"ORF1b: R1622K; ORF3a: M5I; S: L452Q, L455F","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":125,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-27"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF1a":["P309L","H1141Y","E2112D","V3751F"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"]},"labels":{"aa":"N: P365L; ORF1a: P309L, H1141Y, E2112D, V3751F; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R","spike_mutations":"K356T, H681R"}}},{"name":"HK.29","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"ORF1a":["G2509D"]},"labels":{"aa":"ORF1a: G2509D"}}},{"name":"HK.28","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.30","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.32","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.31","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"ORF1a":["G604S"]},"labels":{"aa":"ORF1a: G604S"}}},{"name":"HK.4","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-30"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"ORF1a":["V2019I"],"S":["T307I","L455F"]},"labels":{"aa":"ORF1a: V2019I; S: T307I, L455F","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11.1","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.11","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"ORF1a":["P2144S"],"S":["L455F"]},"labels":{"aa":"ORF1a: P2144S; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-6.294871807098389}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.6088199999999999"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2183176254438959"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000418","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"ORF1a":["T2906N"],"S":["L455F"]},"labels":{"aa":"ORF1a: T2906N; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":113,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":119,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.23.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.48614000000000007"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3534097328298118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"ORF1a":["G268W","E342G","D466N"],"ORF1b":["G2197D"],"S":["A348S"]},"labels":{"aa":"ORF1a: G268W, E342G, D466N; ORF1b: G2197D; S: A348S","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"ORF1a":["A1923T"],"S":["D253G"]},"labels":{"aa":"ORF1a: A1923T; S: D253G","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.919094085693359}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"ORF1a":["T1589I"]},"labels":{"aa":"ORF1a: T1589I"}},"children":[{"name":"HK.27","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000422","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.27.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"ORF1a":["V3660M"],"S":["F186S"]},"labels":{"aa":"ORF1a: V3660M; S: F186S","spike_mutations":"F186S"}},"children":[{"name":"HK.34","node_attrs":{"div":114,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HK.34.1","node_attrs":{"div":117,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18525999999999987"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.3709381401972789"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.2021074295043945}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"NODE_0000426","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":116,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.13.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"ORF1a":["A4357V"],"ORF1b":["T1178A"],"S":["T250I"]},"labels":{"aa":"N: T379I; ORF1a: A4357V; ORF1b: T1178A; S: T250I","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":108,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"EG.5.1.1"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.15","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"ORF1a":["Q991R"],"S":["A262T"]},"labels":{"aa":"ORF1a: Q991R; S: A262T","spike_mutations":"A262T"}}},{"name":"HK.14","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.16","node_attrs":{"div":112,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-13"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-5.089318752288818}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":110,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"0.18829999999999997"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1663965021068448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"clade_membership":{"value":"23F"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":109,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-01"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":111,"clade_display":{"value":"23F (EG.5.1)"},"Nextclade_pango":{"value":"HK.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23F"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23F"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":108,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"clade_membership":{"value":"23H"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3","node_attrs":{"div":108,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-23"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.1366169452667236}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.1","node_attrs":{"div":109,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3.12","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.10","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":112,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.13","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.741405963897705}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":112,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-1.0860600000000002"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.2622098838280695"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"ORF1b":["I2378T"],"S":["A475V"]},"labels":{"aa":"ORF1b: I2378T; S: A475V","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.6","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.5","node_attrs":{"div":114,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"ORF1a":["E1210K"],"S":["P174S"]},"labels":{"aa":"ORF1a: E1210K; S: P174S","spike_mutations":"P174S"}}},{"name":"HK.3.4","node_attrs":{"div":113,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"ORF1a":["T340I"],"S":["P809S"]},"labels":{"aa":"ORF1a: T340I; S: P809S","spike_mutations":"P809S"}}},{"name":"HK.3.9","node_attrs":{"div":113,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.8","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"ORF1b":["T243N"],"S":["E554K"]},"labels":{"aa":"ORF1b: T243N; S: E554K","spike_mutations":"E554K"}}},{"name":"HK.3.7","node_attrs":{"div":110,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"internal_ca7dc568","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"clade_membership":{"value":"23H"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2","node_attrs":{"div":111,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-3.8179337978363037}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.1","node_attrs":{"div":117,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF1a":["E148A","T614I"],"ORF1b":["T2376I"],"ORF8":["A55T"],"S":["Q677H"]},"labels":{"aa":"ORF1a: E148A, T614I; ORF1b: T2376I; ORF8: A55T; S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.3.2.2","node_attrs":{"div":118,"clade_display":{"value":"23H (HK.3)"},"Nextclade_pango":{"value":"HK.3.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23H"},"ace2_binding":{"value":"-0.36673000000000006"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"1.1968892804259947"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-24"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF1a":["G2342E"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"]},"labels":{"aa":"ORF1a: G2342E; ORF3a: I35T; ORF8: M1L; S: N185D","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000431","node_attrs":{"div":0,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.7332983016967773}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.23","node_attrs":{"div":2,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.23"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.23"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.469736099243164}},"branch_attrs":{"mutations":{"nuc":["A1605-","T1606-","G1607-","C20270T","C29870A"],"ORF1a":["D448-"],"ORF1b":["A2268V"]},"labels":{"aa":"ORF1a: D448-; ORF1b: A2268V"}}},{"name":"B.3","node_attrs":{"div":2,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.0303568840026855}},"branch_attrs":{"mutations":{"nuc":["G1440A","G2891A"],"ORF1a":["G392D","A876T"]},"labels":{"aa":"ORF1a: G392D, A876T"}}},{"name":"B.55","node_attrs":{"div":1,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.55"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":0},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.333273410797119}},"branch_attrs":{"mutations":{"nuc":["T514C"]}}},{"name":"internal_f40a","node_attrs":{"div":1,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.376053333282471}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"B.4","node_attrs":{"div":4,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.114970684051514}},"branch_attrs":{"mutations":{"nuc":["G1397A","T28688C","G29742T"],"ORF1a":["V378I"]},"labels":{"aa":"ORF1a: V378I"}}},{"name":"NODE_0000433","node_attrs":{"div":3,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.597896099090576}},"branch_attrs":{"mutations":{"nuc":["C14805T","G26144T"],"ORF3a":["G251V"]},"labels":{"aa":"ORF3a: G251V"}},"children":[{"name":"B.39","node_attrs":{"div":6,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.39"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["A1515G","C9223T","T17247C"],"ORF1a":["H417R"]},"labels":{"aa":"ORF1a: H417R"}}},{"name":"B.40","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.40"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.40"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-3.6938891410827637}},"branch_attrs":{"mutations":{"nuc":["A2480G","C2558T"],"ORF1a":["I739V","P765S"]},"labels":{"aa":"ORF1a: I739V, P765S"}}}]},{"name":"NODE_0000434","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6"},"clade_membership":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{"nuc":["C6312A","C13730T","C23929T","C28311T"],"N":["P13L"],"ORF1a":["T2016K"],"ORF1b":["A88V"],"ORF9b":["P10S"]},"labels":{"aa":"N: P13L; ORF1a: T2016K; ORF1b: A88V; ORF9b: P10S"}},"children":[{"name":"B.6.6","node_attrs":{"div":7,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6.6"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.6.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.402256011962891}},"branch_attrs":{"mutations":{"nuc":["C6310A","C19524T"],"ORF1a":["S2015R"]},"labels":{"aa":"ORF1a: S2015R"}}},{"name":"B.6","node_attrs":{"div":5,"clade_display":{"value":"19A"},"Nextclade_pango":{"value":"B.6"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000435","node_attrs":{"div":3,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.371640682220459}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S","clade":"19B"}},"children":[{"name":"A","node_attrs":{"div":3,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.371640682220459}},"branch_attrs":{"mutations":{}}},{"name":"A.1","node_attrs":{"div":6,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-3.6224653720855713}},"branch_attrs":{"mutations":{"nuc":["C17747T","A17858G","C18060T"],"ORF1b":["P1427L","Y1464C"]},"labels":{"aa":"ORF1b: P1427L, Y1464C"}}},{"name":"A.5","node_attrs":{"div":4,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.451473712921143}},"branch_attrs":{"mutations":{"nuc":["C26088T"]}}},{"name":"A.3","node_attrs":{"div":13,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.0400519371032715}},"branch_attrs":{"mutations":{"nuc":["T490A","C3177T","C6040T","G12478A","T18736C","C24034T","T26729C","G28077C","C28896G","A29700G"],"N":["A208G"],"ORF1a":["D75E","P971L","M4071I"],"ORF1b":["F1757L"],"ORF8":["V62L"]},"labels":{"aa":"N: A208G; ORF1a: D75E, P971L, M4071I; ORF1b: F1757L; ORF8: V62L"}}},{"name":"NODE_0000436","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["T9477A","C14805T","G25979T","C28657T","C28863T"],"N":["S197L"],"ORF1a":["F3071Y"],"ORF3a":["G196V"]},"labels":{"aa":"N: S197L; ORF1a: F3071Y; ORF3a: G196V"}},"children":[{"name":"A.2","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000437","node_attrs":{"div":27,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{"nuc":["C275T","C1567T","C4543T","A5234G","A5488G","C10029T","C11005A","C12815T","C16466T","T16857C","T18417C","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T22917G","A23403G","G24697A","C25613T","C26681T","A28272T","G28975T","C29421T"],"N":["M234I","P383L"],"ORF1a":["L4F","K1657E","T3255I","H3580Q"],"ORF1b":["P1000L"],"ORF3a":["S74F"],"S":["L141-","G142-","V143-","L452R","D614G"]},"labels":{"aa":"N: M234I, P383L; ORF1a: L4F, K1657E, T3255I, H3580Q; ORF1b: P1000L; ORF3a: S74F; S: L141-, G142-, V143-, L452R, D614G","spike_mutations":"L141-, G142-, V143-, L452R, D614G"}},"children":[{"name":"A.2.5","node_attrs":{"div":27,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{}}},{"name":"A.2.5.1","node_attrs":{"div":29,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.277773380279541}},"branch_attrs":{"mutations":{"nuc":["C1722T","C29366T"],"N":["P365S"],"ORF1a":["A486V"]},"labels":{"aa":"N: P365S; ORF1a: A486V"}}},{"name":"A.2.5.2","node_attrs":{"div":30,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.2"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.212984561920166}},"branch_attrs":{"mutations":{"nuc":["T15326C","A22525G","G27706T"],"ORF1b":["M620T"],"ORF7a":["A105S"]},"labels":{"aa":"ORF1b: M620T; ORF7a: A105S"}}},{"name":"A.2.5.3","node_attrs":{"div":30,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.2.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.2.5.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-04"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["G2272A","G22992A","C29870A"],"S":["S477N"]},"labels":{"aa":"S: S477N","spike_mutations":"S477N"}}}]}]},{"name":"NODE_0000438","node_attrs":{"div":5,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.395697593688965}},"branch_attrs":{"mutations":{"nuc":["G28878A","G29742A"],"N":["S202N"]},"labels":{"aa":"N: S202N"}},"children":[{"name":"A.18","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.221602916717529}},"branch_attrs":{"mutations":{"nuc":["A3234T","C15126T","A23403G","C27812T"],"ORF1a":["Q990L"],"S":["D614G"]},"labels":{"aa":"ORF1a: Q990L; S: D614G","spike_mutations":"D614G"}}},{"name":"A.21","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.21"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.21"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C10138T","G11417T","G23402A","G25687T"],"ORF1a":["V3718F"],"ORF3a":["A99S"],"S":["D614N"]},"labels":{"aa":"ORF1a: V3718F; ORF3a: A99S; S: D614N","spike_mutations":"D614N"}}},{"name":"NODE_0000439","node_attrs":{"div":6,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.657860279083252}},"branch_attrs":{"mutations":{"nuc":["G22468T"]}},"children":[{"name":"A.28","node_attrs":{"div":20,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.28"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-18"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A481G","G521T","C2197T","G10850A","C12469T","C16391T","G17014T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A23064C","C23525T","C25904T","C27294T","A27489G","A28272T","C28377T"],"N":["A35V"],"ORF1a":["V86F","A3529T"],"ORF1b":["A975V","D1183Y"],"ORF3a":["S171L"],"ORF9b":["R32C"],"S":["H69-","V70-","N501T","H655Y"]},"labels":{"aa":"N: A35V; ORF1a: V86F, A3529T; ORF1b: A975V, D1183Y; ORF3a: S171L; ORF9b: R32C; S: H69-, V70-, N501T, H655Y","spike_mutations":"H69-, V70-, N501T, H655Y"}}},{"name":"NODE_0000440","node_attrs":{"div":7,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A361G"]}},"children":[{"name":"A.19","node_attrs":{"div":9,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.19"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.19"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12820G","A23403G"],"S":["D614G"]},"labels":{"aa":"S: D614G","spike_mutations":"D614G"}}},{"name":"A.27","node_attrs":{"div":24,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.27"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-18"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C1122T","C2509T","A9204G","A11217G","C16466T","A18366G","A20262G","C21614T","T22917G","A23063T","C23520T","C23525T","G23948T","G25218T","T25541C","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","C27247T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28273T"],"ORF1a":["P286L","D2980G","N3651S"],"ORF1b":["P1000L"],"ORF3a":["V50A","N257-","P258-"],"ORF8":["D119-","F120-"],"S":["L18F","L452R","N501Y","A653V","H655Y","D796Y","G1219V"]},"labels":{"aa":"ORF1a: P286L, D2980G, N3651S; ORF1b: P1000L; ORF3a: V50A, N257-, P258-; ORF8: D119-, F120-; S: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V","spike_mutations":"L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V"}}}]}]},{"name":"NODE_0000441","node_attrs":{"div":7,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G11230T","G28167A"],"ORF1a":["M3655I"],"ORF8":["E92K"]},"labels":{"aa":"ORF1a: M3655I; ORF8: E92K"}},"children":[{"name":"A.25","node_attrs":{"div":8,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.25"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.25"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5544T"],"ORF1a":["T1760I"]},"labels":{"aa":"ORF1a: T1760I"}}},{"name":"A.29","node_attrs":{"div":24,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"S:142-143"},"partiallyAliased":{"value":"A.29"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-21"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G521T","C2110T","C8605T","C9891T","C12970T","G17964T","A19426G","A21069G","G21255T","T21982-","T21983-","T21984-","G21985-","T21992-","A21993-","A22194-","T22195-","T22196-","T22907C","A23063T","T23255C","C23525T","T26767G","G27604T","A28271-","G28337T","C29739T"],"M":["I82S"],"N":["D22Y"],"ORF1a":["V86F","A3209V"],"ORF1b":["M1499I","I1987V"],"ORF7a":["V71L"],"ORF9b":["Q18H"],"S":["F140-","L141-","Y144-","N211-","L212I","Y449H","N501Y","F565L","H655Y"]},"labels":{"aa":"M: I82S; N: D22Y; ORF1a: V86F, A3209V; ORF1b: M1499I, I1987V; ORF7a: V71L; ORF9b: Q18H; S: F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y","spike_mutations":"F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y"}}},{"name":"NODE_0000442","node_attrs":{"div":18,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23"},"clade_membership":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C4573T","C10747T","G11266T","C16575T","C17745T","C22000T","C22033A","G22661T","G23401T","T24097C","G28378C"],"ORF1a":["L3667F"],"ORF9b":["R32P"],"S":["F157L","V367F","Q613H"]},"labels":{"aa":"ORF1a: L3667F; ORF9b: R32P; S: F157L, V367F, Q613H","spike_mutations":"F157L, V367F, Q613H"}},"children":[{"name":"A.23","node_attrs":{"div":18,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.23"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"A.23.1","node_attrs":{"div":20,"clade_display":{"value":"19B"},"Nextclade_pango":{"value":"A.23.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"19B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"A.23.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"19B"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["G11521T","C23604G"],"ORF1a":["M3752I"],"S":["P681R"]},"labels":{"aa":"ORF1a: M3752I; S: P681R","spike_mutations":"P681R"}}}]}]}]}]},{"name":"NODE_0000443","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C14408T","A23403G"],"ORF1b":["P314L"],"S":["D614G"]},"labels":{"aa":"ORF1b: P314L; S: D614G","clade":"20A","spike_mutations":"D614G"}},"children":[{"name":"B.1","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{}}},{"name":"B.1.126","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.126"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.126"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1042866706848145}},"branch_attrs":{"mutations":{"nuc":["T3011C","G22205T","T27869C","T28853G"],"N":["S194A"],"S":["D215Y"]},"labels":{"aa":"N: S194A; S: D215Y","spike_mutations":"D215Y"}}},{"name":"B.1.143","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.143"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.143"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.873954772949219}},"branch_attrs":{"mutations":{"nuc":["C4084T"]}}},{"name":"B.1.128","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.128"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.128"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9753756523132324}},"branch_attrs":{"mutations":{"nuc":["C8293T","T18488C","T24739C","A26530G"],"M":["D3G"],"ORF1b":["I1674T"]},"labels":{"aa":"M: D3G; ORF1b: I1674T"}}},{"name":"B.1.179","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.179"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.179"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.5756611824035645}},"branch_attrs":{"mutations":{"nuc":["C7834T"]}}},{"name":"B.1.195","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.195"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.195"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.644052028656006}},"branch_attrs":{"mutations":{"nuc":["A1T","A6466G"]}}},{"name":"B.1.206","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.206"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.206"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.032867431640625}},"branch_attrs":{"mutations":{"nuc":["G2282A","T9742C","C17639T"],"ORF1a":["E673K"],"ORF1b":["S1391L"]},"labels":{"aa":"ORF1a: E673K; ORF1b: S1391L"}}},{"name":"B.1.22","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.22"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.22"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.218015670776367}},"branch_attrs":{"mutations":{"nuc":["C1594T","C11109T","G25563T"],"ORF1a":["A3615V"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: A3615V; ORF3a: Q57H"}}},{"name":"B.1.222","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.222"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.222"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.234422206878662}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.247","node_attrs":{"div":4,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.247"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.247"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0538268089294434}},"branch_attrs":{"mutations":{}}},{"name":"B.1.260","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.260"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.260"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.373773574829102}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}}},{"name":"B.1.298","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.298"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.298"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.417770862579346}},"branch_attrs":{"mutations":{"nuc":["C1059T","G5012T","C19488T","G25563T","T28843G"],"N":["S190R"],"ORF1a":["T265I","V1583F"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S190R; ORF1a: T265I, V1583F; ORF3a: Q57H"}}},{"name":"B.1.311","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.311"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.311"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6185555458068848}},"branch_attrs":{"mutations":{"nuc":["C1059T","A5011C","C12525T","G25563T","C27920T","C28893T"],"N":["P207L"],"ORF1a":["T265I","Q1582H","T4087I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: P207L; ORF1a: T265I, Q1582H, T4087I; ORF3a: Q57H"}}},{"name":"B.1.319","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.319"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.319"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.19646692276001}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10851T","G25563T"],"ORF1a":["T265I","A3529V"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, A3529V; ORF3a: Q57H"}}},{"name":"B.1.324","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.324"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.324"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.300193786621094}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7528T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.320","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.320"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.320"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.052657604217529}},"branch_attrs":{"mutations":{"nuc":["A1G","C379A","C1059T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.349","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.349"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.349"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.087948799133301}},"branch_attrs":{"mutations":{"nuc":["C1059T","C18555T","G25563T","C28892T"],"N":["P207S"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: P207S; ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.340","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.340"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.340"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.638462543487549}},"branch_attrs":{"mutations":{"nuc":["C1059T","A4197G","G25563T","A28715T"],"N":["T148S"],"ORF1a":["T265I","E1311G"],"ORF3a":["Q57H"]},"labels":{"aa":"N: T148S; ORF1a: T265I, E1311G; ORF3a: Q57H"}}},{"name":"B.1.350","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.350"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.350"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515401363372803}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25217T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"S":["G1219C"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; S: G1219C","spike_mutations":"G1219C"}}},{"name":"B.1.356","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.356"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.356"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.372903347015381}},"branch_attrs":{"mutations":{"nuc":["C1059T","T13006C","G25563T","C25688T"],"ORF1a":["T265I"],"ORF3a":["Q57H","A99V"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H, A99V"}}},{"name":"B.1.371","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.371"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.371"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0627546310424805}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","G29553A"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.377","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.377"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.377"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.690332889556885}},"branch_attrs":{"mutations":{"nuc":["G28300T","G28883A","A28998G"],"N":["Q9H","G204R","Q242R"],"ORF9b":["S6I"]},"labels":{"aa":"N: Q9H, G204R, Q242R; ORF9b: S6I"}}},{"name":"B.1.379","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.379"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.379"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.871178150177002}},"branch_attrs":{"mutations":{"nuc":["A11782G"]}}},{"name":"B.1.380","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.380"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.380"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0439043045043945}},"branch_attrs":{"mutations":{"nuc":["C7420T","C12439T","T26017G"],"ORF3a":["S209A"]},"labels":{"aa":"ORF3a: S209A"}}},{"name":"B.1.391","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.391"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.391"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.035602569580078}},"branch_attrs":{"mutations":{"nuc":["C16289T","G25429T"],"ORF1b":["A941V"],"ORF3a":["V13L"]},"labels":{"aa":"ORF1b: A941V; ORF3a: V13L"}}},{"name":"B.1.393","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.393"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.393"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.20594596862793}},"branch_attrs":{"mutations":{"nuc":["A5040G","G29477T","C29774T"],"N":["D402Y"],"ORF1a":["Q1592R"]},"labels":{"aa":"N: D402Y; ORF1a: Q1592R"}}},{"name":"B.1.395","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.395"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.395"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.245898246765137}},"branch_attrs":{"mutations":{"nuc":["C6990T"],"ORF1a":["S2242F"]},"labels":{"aa":"ORF1a: S2242F"}}},{"name":"B.1.411","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.411"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.411"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.553281307220459}},"branch_attrs":{"mutations":{"nuc":["C1519T","A14774G","G15438T","T16062C","G17334T","C25037T","C27945T"],"ORF1b":["D436G","M657I"],"ORF8":["Q18*"],"S":["H1159Y"]},"labels":{"aa":"ORF1b: D436G, M657I; ORF8: Q18*; S: H1159Y","spike_mutations":"H1159Y"}}},{"name":"B.1.428","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.428"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.428"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.162219524383545}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1302T","G25563T"],"ORF1a":["T265I","T346I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, T346I; ORF3a: Q57H"}}},{"name":"B.1.453","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.453"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.453"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.023926258087158}},"branch_attrs":{"mutations":{"nuc":["C1059T","C2668T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.517","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.517"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.517"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8103365898132324}},"branch_attrs":{"mutations":{"nuc":["C1059T","G3231T","A12850G","C21364T","A23064C","G25563T","C28890T"],"N":["S206F"],"ORF1a":["T265I","G989V"],"ORF1b":["P2633S"],"ORF3a":["Q57H"],"S":["N501T"]},"labels":{"aa":"N: S206F; ORF1a: T265I, G989V; ORF1b: P2633S; ORF3a: Q57H; S: N501T","spike_mutations":"N501T"}}},{"name":"B.1.527","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.527"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.527"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.679739952087402}},"branch_attrs":{"mutations":{"nuc":["A1G","C6354T"],"ORF1a":["S2030L"]},"labels":{"aa":"ORF1a: S2030L"}}},{"name":"B.1.537","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.537"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.537"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.6834211349487305}},"branch_attrs":{"mutations":{"nuc":["G4354A","C6573T","C25528T"],"ORF1a":["S2103F"],"ORF3a":["L46F"]},"labels":{"aa":"ORF1a: S2103F; ORF3a: L46F"}}},{"name":"B.1.538","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.538"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.538"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.957637310028076}},"branch_attrs":{"mutations":{"nuc":["C313T","C5700A","C29870A"],"ORF1a":["A1812D"]},"labels":{"aa":"ORF1a: A1812D"}}},{"name":"B.1.540","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.540"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.540"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.101133823394775}},"branch_attrs":{"mutations":{"nuc":["G28221T"],"ORF8":["E110*"]},"labels":{"aa":"ORF8: E110*"}}},{"name":"B.1.544","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.544"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.544"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.623403549194336}},"branch_attrs":{"mutations":{"nuc":["G13348T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"B.1.549","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.549"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.549"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.000475883483887}},"branch_attrs":{"mutations":{"nuc":["C1514T","G5542T","C10029T","A11451G","G17122T","G17320T","C18463T","G23611A"],"ORF1a":["H417Y","Q1759H","T3255I","Q3729R"],"ORF1b":["A1219S","A1285S","P1666S"]},"labels":{"aa":"ORF1a: H417Y, Q1759H, T3255I, Q3729R; ORF1b: A1219S, A1285S, P1666S"}}},{"name":"B.1.560","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.560"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.560"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.553897380828857}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}}},{"name":"B.1.566","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.566"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.566"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.201295375823975}},"branch_attrs":{"mutations":{"nuc":["C1059T","C13860T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.570","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.570"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.570"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.377383232116699}},"branch_attrs":{"mutations":{"nuc":["C1059T","T7767C","G11087A","C13452T","C21161T","C23604T","G25455T","G25563T","T29867A","G29868A","C29870A"],"ORF1a":["T265I","I2501T","E3608K","A4396V"],"ORF1b":["A2565V"],"ORF3a":["K21N","Q57H"],"S":["P681L"]},"labels":{"aa":"ORF1a: T265I, I2501T, E3608K, A4396V; ORF1b: A2565V; ORF3a: K21N, Q57H; S: P681L","spike_mutations":"P681L"}}},{"name":"B.1.576","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.576"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.576"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.5748648643493652}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H"}}},{"name":"B.1.606","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.606"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.606"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.854406833648682}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10015T","G14829T","C23191T","G25563T","G26769T"],"M":["A83S"],"ORF1a":["T265I"],"ORF1b":["M454I"],"ORF3a":["Q57H"]},"labels":{"aa":"M: A83S; ORF1a: T265I; ORF1b: M454I; ORF3a: Q57H"}}},{"name":"B.1.605","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.605"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.605"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.770111560821533}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10747T","C13694T","T14103C","C24909A","G25563T"],"ORF1a":["T265I"],"ORF1b":["T76I"],"ORF3a":["Q57H"],"S":["T1116N"]},"labels":{"aa":"ORF1a: T265I; ORF1b: T76I; ORF3a: Q57H; S: T1116N","spike_mutations":"T1116N"}}},{"name":"B.1.618","node_attrs":{"div":25,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.618"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.618"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-13"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G105T","C853T","C1684T","A3830G","C4809T","T5263C","G14245A","A17066G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","G23012A","T25084C","C25844T","C26885T","G26909T","C27493T","G27852T","A27979T","G28325A","G28628T","G28922T","G28975T","G29372C"],"N":["G18S","A119S","A217S","M234I","E367Q"],"ORF1a":["S1189G","S1515F"],"ORF1b":["D260N","Y1200C"],"ORF3a":["T151I"],"ORF7a":["P34S"],"ORF7b":["E33*"],"ORF8":["Q29L"],"S":["Y145-","H146-","E484K"]},"labels":{"aa":"N: G18S, A119S, A217S, M234I, E367Q; ORF1a: S1189G, S1515F; ORF1b: D260N, Y1200C; ORF3a: T151I; ORF7a: P34S; ORF7b: E33*; ORF8: Q29L; S: Y145-, H146-, E484K","spike_mutations":"Y145-, H146-, E484K"}}},{"name":"B.1.639","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.639"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.639"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.9996724128723145}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22020C","C22995A","G23012A","C24138A","G24368T","A26161-","T27919C","A28271G","A28742G"],"N":["I157V"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF3a":["N257-"],"ORF8":["I9T"],"S":["H69-","V70-","M153T","T478K","E484K","T859N","D936Y"]},"labels":{"aa":"N: I157V; ORF1a: S3675-, G3676-, F3677-; ORF3a: N257-; ORF8: I9T; S: H69-, V70-, M153T, T478K, E484K, T859N, D936Y","spike_mutations":"H69-, V70-, M153T, T478K, E484K, T859N, D936Y"}}},{"name":"B.1.78","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.78"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.78"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.457021713256836}},"branch_attrs":{"mutations":{"nuc":["G29422T"]}}},{"name":"B.1.8","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.388116359710693}},"branch_attrs":{"mutations":{"nuc":["A24862G"]}}},{"name":"B.1.91","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.91"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.91"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.194854259490967}},"branch_attrs":{"mutations":{"nuc":["G24077T"],"S":["D839Y"]},"labels":{"aa":"S: D839Y","spike_mutations":"D839Y"}}},{"name":"NODE_0000444","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515961647033691}},"branch_attrs":{"mutations":{"nuc":["C8389T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.110","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.110"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.515961647033691}},"branch_attrs":{"mutations":{}}},{"name":"B.1.110.3","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.110.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.110.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.013051509857178}},"branch_attrs":{"mutations":{"nuc":["C601T","G27915A"],"ORF8":["G8R"]},"labels":{"aa":"ORF8: G8R"}}}]},{"name":"NODE_0000445","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.175020217895508}},"branch_attrs":{"mutations":{"nuc":["C1059T","C10582T","G25563T","C27804T","C28830A"],"N":["S186Y"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S186Y; ORF1a: T265I; ORF3a: Q57H"}},"children":[{"name":"B.1.367","node_attrs":{"div":27,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.367"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.367"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C3099T","G4960T","C4965T","C6070T","C7303T","C7564T","C9246T","C10279T","C10301A","C10525T","G10688T","G11851T","C14230A","G21800T","G27632T","G29402T","G29779T"],"N":["D377Y"],"ORF1a":["T945I","T1567I","A2994V","Q3346K","V3475F","M3862I"],"ORF1b":["P255T"],"ORF7a":["R80I"],"S":["D80Y"]},"labels":{"aa":"N: D377Y; ORF1a: T945I, T1567I, A2994V, Q3346K, V3475F, M3862I; ORF1b: P255T; ORF7a: R80I; S: D80Y","spike_mutations":"D80Y"}}},{"name":"B.1.597","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.597"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.597"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.175020217895508}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000446","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{"nuc":["C1059T","C16260T","G25563T","C28821A"],"N":["S183Y"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S183Y; ORF1a: T265I; ORF3a: Q57H"}},"children":[{"name":"B.1.369","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.369"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.369"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{"nuc":["A1C"]}}},{"name":"B.1.564","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.564"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.564"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7091031074523926}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000447","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.648159980773926}},"branch_attrs":{"mutations":{"nuc":["C2416T","C14322T","C23604A","G23948T","G25563T","T26038C"],"ORF3a":["Q57H","S216P"],"S":["P681H","D796Y"]},"labels":{"aa":"ORF3a: Q57H, S216P; S: P681H, D796Y","spike_mutations":"P681H, D796Y"}},"children":[{"name":"B.1.474","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.474"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.474"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.585629463195801}},"branch_attrs":{"mutations":{"nuc":["C539T","C5884T","C7834T","G8618A","C15579T","G16912T","C25207T","C26600T","C27970A","C28887T"],"N":["T205I"],"ORF1a":["L92F","A2785T"],"ORF1b":["V1149L"],"ORF8":["T26N"]},"labels":{"aa":"N: T205I; ORF1a: L92F, A2785T; ORF1b: V1149L; ORF8: T26N"}}},{"name":"B.1.629","node_attrs":{"div":29,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.629"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.629"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-01"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C815T","C1191T","C3040T","A4229C","T5095C","C5178T","G11128A","C12459T","G21987A","A22107G","T22917G","C22995A","G25266T","C25433T","T26498C","T26767G","A28482G","C28833T","C28926T"],"M":["I82S"],"N":["Q70R","S187L","A218V"],"ORF1a":["R184C","P309L","T1322P","T1638I","M3621I","T4065I"],"ORF3a":["T14I"],"ORF9b":["K67E"],"S":["G142D","K182R","L452R","T478K","C1235F"]},"labels":{"aa":"M: I82S; N: Q70R, S187L, A218V; ORF1a: R184C, P309L, T1322P, T1638I, M3621I, T4065I; ORF3a: T14I; ORF9b: K67E; S: G142D, K182R, L452R, T478K, C1235F","spike_mutations":"G142D, K182R, L452R, T478K, C1235F"}}}]},{"name":"NODE_0000448","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.43609094619751}},"branch_attrs":{"mutations":{"nuc":["C1059T","T9867C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C25517T","G25563T","C27925T","A28271-"],"ORF1a":["T265I","L3201P","S3675-","G3676-","F3677-"],"ORF3a":["P42L","Q57H"],"ORF8":["T11I"]},"labels":{"aa":"ORF1a: T265I, L3201P, S3675-, G3676-, F3677-; ORF3a: P42L, Q57H; ORF8: T11I"}},"children":[{"name":"B.1.526","node_attrs":{"div":14,"clade_display":{"value":"21F (Iota)"},"Nextclade_pango":{"value":"B.1.526"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21F"},"clade_who":{"value":"Iota"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.526"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"21F"},"placement_prior":{"value":-2.5307040214538574}},"branch_attrs":{"mutations":{"nuc":["A16500C","A20262G","C21575T","C21846T","A22320G"],"ORF1b":["Q1011H"],"S":["L5F","T95I","D253G"]},"labels":{"aa":"ORF1b: Q1011H; S: L5F, T95I, D253G","clade":"Iota","spike_mutations":"L5F, T95I, D253G"}}},{"name":"B.1.637","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.637"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.637"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0134620666503906}},"branch_attrs":{"mutations":{"nuc":["A9749G","C9891T","G11804A","A21801G","T21992-","A21993-","T21994-","T22032C","T22917G","C24138A","G24410C","G28044T","C28887T","G28975A"],"N":["T205I","M234I"],"ORF1a":["K3162E","A3209V","V3847I"],"ORF8":["A51S"],"S":["D80G","Y144-","F157S","L452R","T859N","D950H"]},"labels":{"aa":"N: T205I, M234I; ORF1a: K3162E, A3209V, V3847I; ORF8: A51S; S: D80G, Y144-, F157S, L452R, T859N, D950H","spike_mutations":"D80G, Y144-, F157S, L452R, T859N, D950H"}}}]},{"name":"NODE_0000449","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.79054069519043}},"branch_attrs":{"mutations":{"nuc":["G3871T"],"ORF1a":["K1202N"]},"labels":{"aa":"ORF1a: K1202N"}},"children":[{"name":"B.1.378","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.378"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.378"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.79054069519043}},"branch_attrs":{"mutations":{"nuc":["A6-","G7-","G8-","T9-","T13-","A14-","C15-","C16-","T17-","T18-","C19-","C20-","C21-","A22-","G23-","G24-"]}}},{"name":"NODE_0000450","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.390692710876465}},"branch_attrs":{"mutations":{"nuc":["A696C","T3931C","C28977T"],"N":["S235F"],"ORF1a":["D144A"]},"labels":{"aa":"N: S235F; ORF1a: D144A"}},"children":[{"name":"B.1.139","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.139"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.139"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.390692710876465}},"branch_attrs":{"mutations":{}}},{"name":"B.1.565","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.565"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.565"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.867055892944336}},"branch_attrs":{"mutations":{"nuc":["C6285T","C19524T","C20429T"],"ORF1a":["T2007I"],"ORF1b":["P2321L"]},"labels":{"aa":"ORF1a: T2007I; ORF1b: P2321L"}}}]}]},{"name":"NODE_0000451","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.336426258087158}},"branch_attrs":{"mutations":{"nuc":["C1059T","C6730T","T23042C","C23604A","G25563T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"S":["S494P","P681H"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; S: S494P, P681H","spike_mutations":"S494P, P681H"}},"children":[{"name":"B.1.623","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.623"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.623"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-13"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["T8704C","C9120T","C9870T","C11005A","C12854T","C13458T","G14559A","A23063T","G24893A","A27926-","A27927-","C27928-","T27929-","G27930-","T27931-","A27932-","G27933-","C27934-","T27935-","G27936-","C27937-","A27938-","T27939-","T27940-","T27941-","C27942-","A27943-","C27944-","C27945-","A27946-","A27947-","G27948-","A27949-","A27950-","T27951-","G27952-","T27953-","A27954-","G27955-","A28272T","G28975A"],"N":["M234I"],"ORF1a":["T2952I","T3202M","H3580Q","P4197S","S4398L"],"ORF8":["T12-","V13-","A14-","A15-","F16-","H17-","Q18-","E19-","C20-","S21-"],"S":["N501Y","E1111K"]},"labels":{"aa":"N: M234I; ORF1a: T2952I, T3202M, H3580Q, P4197S, S4398L; ORF8: T12-, V13-, A14-, A15-, F16-, H17-, Q18-, E19-, C20-, S21-; S: N501Y, E1111K","spike_mutations":"N501Y, E1111K"}}},{"name":"NODE_0000452","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8313348293304443}},"branch_attrs":{"mutations":{"nuc":["A1C","A1180G","C6936T","C10029T","C11514T","C16375T","T20748C","C23709T","T26767C","A28271-","C28887T","G29711-","C29719T"],"M":["I82T"],"N":["T205I"],"ORF1a":["S2224F","T3255I","T3750I"],"ORF1b":["P970S"],"S":["T716I"]},"labels":{"aa":"M: I82T; N: T205I; ORF1a: S2224F, T3255I, T3750I; ORF1b: P970S; S: T716I","spike_mutations":"T716I"}},"children":[{"name":"B.1.575","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.575"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8313348293304443}},"branch_attrs":{"mutations":{}}},{"name":"B.1.575.1","node_attrs":{"div":22,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.575.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.575.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.644876003265381}},"branch_attrs":{"mutations":{"nuc":["G29513T","C29614T"],"N":["A414S"]},"labels":{"aa":"N: A414S"}}}]}]},{"name":"NODE_0000453","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.800264835357666}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","C23625T","A26161-"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"B.1.634","node_attrs":{"div":27,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.634"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.634"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G613A","C841T","A7142G","T8634C","A9614G","C9693T","A9754C","C11289-","G11291-","G11292-","G15451A","C16466T","C20823T","T21615G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A22036C","G23012A","C23854A","C26681T","T27645C","C27735T","A28271T","C28531T","C28606T","A28910T"],"N":["N213Y"],"ORF1a":["S2293G","I2790T","T3117A","A3143V","R3163S","S3675-","G3676-","F3677-"],"ORF1b":["G662S","P1000L"],"ORF3a":["N257-"],"ORF9b":["T83I"],"S":["L18R","H69-","V70-","T95I","R158S","E484K","N764K"]},"labels":{"aa":"N: N213Y; ORF1a: S2293G, I2790T, T3117A, A3143V, R3163S, S3675-, G3676-, F3677-; ORF1b: G662S, P1000L; ORF3a: N257-; ORF9b: T83I; S: L18R, H69-, V70-, T95I, R158S, E484K, N764K","spike_mutations":"L18R, H69-, V70-, T95I, R158S, E484K, N764K"}}},{"name":"NODE_0000454","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.438127517700195}},"branch_attrs":{"mutations":{"nuc":["C24642T"],"S":["T1027I"]},"labels":{"aa":"S: T1027I","spike_mutations":"T1027I"}},"children":[{"name":"B.1.636","node_attrs":{"div":18,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.636"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.636"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","C5907T","C5986T","A9085G","C11289-","G11291-","G11292-","C21614T","A22005C","G23867A","C25931T","-26161A","C27925T","A28295T","A28742G","G29734C"],"N":["N8Y","I157V"],"ORF1a":["T1881I","S3675-","G3676-","F3677-"],"ORF3a":["S180F"],"ORF8":["T11I"],"ORF9b":["K4N"],"S":["L18F","N148T","G769R"]},"labels":{"aa":"N: N8Y, I157V; ORF1a: T1881I, S3675-, G3676-, F3677-; ORF3a: S180F; ORF8: T11I; ORF9b: K4N; S: L18F, N148T, G769R","spike_mutations":"L18F, N148T, G769R"}}},{"name":"NODE_0000455","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A994G","G9756A","C9924T","A10982G","G11283-","T11284-","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C23604A","T23765G","C24442T","G26158-","T26159-","T26160-","C26222T"],"ORF1a":["R3164H","A3220V","K3573E","S3673-"],"ORF3a":["V256-","N257-"],"S":["P681H","S735A"]},"labels":{"aa":"ORF1a: R3164H, A3220V, K3573E, S3673-; ORF3a: V256-, N257-; S: P681H, S735A","spike_mutations":"P681H, S735A"}},"children":[{"name":"B.1.627","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.627"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.627"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-01"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["C1912T","C7869T","C9611T","T11285-","T20124A","T21752A","T22020C","C28923T","T29574-","T29575-","T29576-","T29577-","C29578-","G29579-","C29580-"],"N":["A217V"],"ORF1a":["S2535L","L3116F","L3674M"],"S":["W64R","M153T"]},"labels":{"aa":"N: A217V; ORF1a: S2535L, L3116F, L3674M; S: W64R, M153T","spike_mutations":"W64R, M153T"}}},{"name":"B.1.631","node_attrs":{"div":28,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.631"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.631"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-26"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C829T","C4534T","C6120T","G7787A","A11282-","T21615G","C21846T","A22036C","C22916A","C25465T","C27769T","A28271-","A28330G","C28830T","G28907T","C28957T"],"N":["S186F","G212C"],"ORF1a":["S1952L","A2508T"],"ORF3a":["P25S"],"ORF7b":["S5L"],"ORF9b":["D16G"],"S":["L18R","T95I","R158S","L452M"]},"labels":{"aa":"N: S186F, G212C; ORF1a: S1952L, A2508T; ORF3a: P25S; ORF7b: S5L; ORF9b: D16G; S: L18R, T95I, R158S, L452M","spike_mutations":"L18R, T95I, R158S, L452M"}}}]}]}]},{"name":"NODE_0000456","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8648552894592285}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.524","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.524"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.524"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.313449859619141}},"branch_attrs":{"mutations":{"nuc":["C6312T","C8637T","A10124G","C17518T","C21516T","C21622A","C23664T","A28133T"],"ORF1a":["T2016I","T2791I","T3287A"],"ORF1b":["L1351F"],"S":["A701V"]},"labels":{"aa":"ORF1a: T2016I, T2791I, T3287A; ORF1b: L1351F; S: A701V","spike_mutations":"A701V"}}},{"name":"NODE_0000457","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.2996320724487305}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.362","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.362"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.362"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.244770526885986}},"branch_attrs":{"mutations":{"nuc":["C683T","C1059T","C6402T","T10249C","G11083T","G17427T"],"ORF1a":["T265I","P2046L","L3606F"]},"labels":{"aa":"ORF1a: T265I, P2046L, L3606F"}}},{"name":"NODE_0000458","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.4366543292999268}},"branch_attrs":{"mutations":{"nuc":["C2416T"]}},"children":[{"name":"B.1.279","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.279"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.279"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.854538679122925}},"branch_attrs":{"mutations":{"nuc":["C1913T","G2528A","C12525T","C16806T","G20014T","A25718G","T28854C"],"N":["L194S"],"ORF1a":["R550C","E755K","T4087I"],"ORF1b":["D2183Y"],"ORF3a":["Y109C"]},"labels":{"aa":"N: L194S; ORF1a: R550C, E755K, T4087I; ORF1b: D2183Y; ORF3a: Y109C"}}},{"name":"B.1.389","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.389"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.389"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G8371T","C9430T","A15477T","C18395T","A20622T","G20623T","A20624T","C23730T","A26319G","G29044A"],"ORF1a":["Q2702H"],"ORF1b":["A1643V","K2385N","D2386F"],"S":["T723I"]},"labels":{"aa":"ORF1a: Q2702H; ORF1b: A1643V, K2385N, D2386F; S: T723I","spike_mutations":"T723I"}}},{"name":"B.1.480","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.480"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.480"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.699548721313477}},"branch_attrs":{"mutations":{"nuc":["C875T","A10904G","G25249T"],"ORF1a":["L204F","S3547G"],"S":["M1229I"]},"labels":{"aa":"ORF1a: L204F, S3547G; S: M1229I","spike_mutations":"M1229I"}}}]}]}]},{"name":"NODE_0000459","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.48314905166626}},"branch_attrs":{"mutations":{"nuc":["C1059T","A10323G","G25563T","G28842T"],"N":["S190I"],"ORF1a":["T265I","K3353R"],"ORF3a":["Q57H"]},"labels":{"aa":"N: S190I; ORF1a: T265I, K3353R; ORF3a: Q57H"}},"children":[{"name":"B.1.361","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.361"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.361"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0868425369262695}},"branch_attrs":{"mutations":{"nuc":["A705G","G1463A","G11417T","C18167T","A21080G","G29779T"],"ORF1a":["D147G","G400S","V3718F"],"ORF1b":["P1567L","K2538R"]},"labels":{"aa":"ORF1a: D147G, G400S, V3718F; ORF1b: P1567L, K2538R"}}},{"name":"B.1.580","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.580"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.580"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.48314905166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000460","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{"nuc":["T15276A"]}},"children":[{"name":"B.1.568","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.568"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.568"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097565650939941}},"branch_attrs":{"mutations":{"nuc":["C5654T","C10450T","C12049T","C12455A","C16428T","C17483T","G25913A","G27916T"],"ORF1a":["L4064I"],"ORF1b":["T1339I"],"ORF3a":["G174D"],"ORF8":["G8V"]},"labels":{"aa":"ORF1a: L4064I; ORF1b: T1339I; ORF3a: G174D; ORF8: G8V"}}},{"name":"B.1.582","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.582"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.582"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{}}},{"name":"B.1.612","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.612"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.612"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.187291145324707}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000461","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.893455743789673}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.530","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.530"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.530"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G61T","A3291G","C11050T","G16935T","A19339G","C23604A","C26549T","T29471C"],"ORF1a":["Q1009R"],"ORF1b":["M1156I","S1958G"],"S":["P681H"]},"labels":{"aa":"ORF1a: Q1009R; ORF1b: M1156I, S1958G; S: P681H","spike_mutations":"P681H"}}},{"name":"NODE_0000462","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.436675548553467}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","A21768-","T21769-","G21770-","G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.415.1","node_attrs":{"div":29,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.415.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.415.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1150T","T7185C","C8251T","A11023T","A11217G","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C13458T","G15732T","T16348C","A16619G","A18410G","T19143C","A20268G","C21767-","C22286-","T22287-","T22288-","G22299C","G22599A","A23064C","C23604A","C24138A","C24507T","G26840T","G28178A","A28271-","G28302A","C28932T"],"N":["R10Q","A220V"],"ORF1a":["I2307T","N3651S","S4398L"],"ORF1b":["S961P","E1051G","Y1648C"],"ORF9b":["E7K"],"S":["H69-","V70-","L241-","R246T","R346K","N501T","P681H","T859N","S982L"]},"labels":{"aa":"N: R10Q, A220V; ORF1a: I2307T, N3651S, S4398L; ORF1b: S961P, E1051G, Y1648C; ORF9b: E7K; S: H69-, V70-, L241-, R246T, R346K, N501T, P681H, T859N, S982L","spike_mutations":"H69-, V70-, L241-, R246T, R346K, N501T, P681H, T859N, S982L"}}},{"name":"B.1.525","node_attrs":{"div":24,"clade_display":{"value":"21D (Eta)"},"Nextclade_pango":{"value":"B.1.525"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21D"},"clade_who":{"value":"Eta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.525"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"21D"},"placement_prior":{"value":-3.212512969970703}},"branch_attrs":{"mutations":{"nuc":["C1498T","A1807G","G2659A","C6285T","T8593C","C9565T","C11289-","G11291-","G11292-","C14407T","C18171T","A20724G","A21717G","C21762T","C21767-","T21992-","A21993-","T21994-","G23593C","T24224C","C24748T","T27205-","T27206-","T27207-","C28278-","T28279-","G28280-","C28308G","A28699G","G29543T"],"N":["S2-","D3Y","A12G"],"ORF1a":["T2007I","S3675-","G3676-","F3677-"],"ORF1b":["L314F"],"ORF6":["F2-"],"ORF9b":["H9D"],"S":["Q52R","A67V","H69-","V70-","Y144-","Q677H","F888L"]},"labels":{"aa":"N: S2-, D3Y, A12G; ORF1a: T2007I, S3675-, G3676-, F3677-; ORF1b: L314F; ORF6: F2-; ORF9b: H9D; S: Q52R, A67V, H69-, V70-, Y144-, Q677H, F888L","clade":"Eta","spike_mutations":"Q52R, A67V, H69-, V70-, Y144-, Q677H, F888L"}}},{"name":"NODE_0000463","node_attrs":{"div":30,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2407A","G5008T","C6633T","G8084A","C8311T","C9319T","C11289-","G11291-","G11292-","G11521T","C12473T","C14403T","C15324T","G19962A","C21637T","-21765T","-21766A","-21768A","-21769T","-21770G","T22191C","T22882G","T24194C","G24368A","C24378T","C24642T","G26211T","C26606T","G27459T","C28311T","G28875T"],"N":["P13L","S201I"],"ORF1a":["A2123V","E2607K","S3675-","G3676-","F3677-","M3752I"],"ORF7a":["E22D"],"ORF9b":["P10S"],"S":["I210T","N440K","D936N","S939F","T1027I"]},"labels":{"aa":"N: P13L, S201I; ORF1a: A2123V, E2607K, S3675-, G3676-, F3677-, M3752I; ORF7a: E22D; ORF9b: P10S; S: I210T, N440K, D936N, S939F, T1027I","spike_mutations":"I210T, N440K, D936N, S939F, T1027I"}},"children":[{"name":"B.1.619.1","node_attrs":{"div":38,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.619.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-27"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C19T","T5701C","A12051G","A21213G","T22738C","A28271-","C28441T","T28600C","C28957T"],"ORF1a":["K3929R"],"ORF9b":["S53L"]},"labels":{"aa":"ORF1a: K3929R; ORF9b: S53L"}}},{"name":"B.1.619","node_attrs":{"div":30,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.619"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.619"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-20"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000464","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.037975788116455}},"branch_attrs":{"mutations":{"nuc":["C1059T","C11916T","G25563T"],"ORF1a":["T265I","S3884L"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF1a: T265I, S3884L; ORF3a: Q57H"}},"children":[{"name":"B.1.3","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C715T","A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"B.1.497","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.497"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.497"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A1G","C16650T","A20675T","G29179T"],"ORF1b":["Q2403L"]},"labels":{"aa":"ORF1b: Q2403L"}}},{"name":"B.1.509","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.509"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.509"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.097174167633057}},"branch_attrs":{"mutations":{"nuc":["C1385T","G1738T","G3242A","C28087T"],"ORF1a":["H374Y","G993S"],"ORF8":["A65V"]},"labels":{"aa":"ORF1a: H374Y, G993S; ORF8: A65V"}}},{"name":"NODE_0000465","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8570423126220703}},"branch_attrs":{"mutations":{"nuc":["C18998T","G29540A"],"ORF1b":["A1844V"]},"labels":{"aa":"ORF1b: A1844V"}},"children":[{"name":"B.1.503","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.503"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.503"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25947C"],"ORF3a":["Q185H"]},"labels":{"aa":"ORF3a: Q185H"}}},{"name":"B.1.499","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.499"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.499"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["C28863T"],"N":["S197L"]},"labels":{"aa":"N: S197L"}}},{"name":"B.1.505","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.505"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.505"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C66A","C7768T","A8773G","C17304T","T24805C"]}}}]}]},{"name":"NODE_0000466","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.3400766849517822}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","C27964T"],"ORF1a":["T265I"],"ORF3a":["Q57H"],"ORF8":["S24L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: Q57H; ORF8: S24L"}},"children":[{"name":"B.1.265","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.265"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.265"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.216925144195557}},"branch_attrs":{"mutations":{"nuc":["C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}}},{"name":"B.1.336","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.336"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.336"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.552525043487549}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}}},{"name":"B.1.426","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.426"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.426"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8291878700256348}},"branch_attrs":{"mutations":{"nuc":["T833C","A22320G"],"ORF1a":["F190L"],"S":["D253G"]},"labels":{"aa":"ORF1a: F190L; S: D253G","spike_mutations":"D253G"}}},{"name":"NODE_0000467","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.473392963409424}},"branch_attrs":{"mutations":{"nuc":["A18424G","G25907T"],"ORF1b":["N1653D"],"ORF3a":["G172V"]},"labels":{"aa":"ORF1b: N1653D; ORF3a: G172V"}},"children":[{"name":"B.1.2","node_attrs":{"div":13,"clade_display":{"value":"20G"},"Nextclade_pango":{"value":"B.1.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20G"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20G"},"placement_prior":{"value":-2.0290510654449463}},"branch_attrs":{"mutations":{"nuc":["C10319T","C21304T","C28472T","C28869T"],"N":["P67S","P199L"],"ORF1a":["L3352F"],"ORF1b":["R2613C"]},"labels":{"aa":"N: P67S, P199L; ORF1a: L3352F; ORF1b: R2613C","clade":"20G"}}},{"name":"B.1.596","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.596"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.596"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.473392963409424}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000468","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7301440238952637}},"branch_attrs":{"mutations":{"nuc":["C10319T"],"ORF1a":["L3352F"]},"labels":{"aa":"ORF1a: L3352F"}},"children":[{"name":"B.1.567","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.567"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.567"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.657745838165283}},"branch_attrs":{"mutations":{"nuc":["C11575T","A20262G","G21305A","C28868T"],"N":["P199S"],"ORF1b":["R2613H"]},"labels":{"aa":"N: P199S; ORF1b: R2613H"}}},{"name":"B.1.577","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.577"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.577"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8689005374908447}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"B.1.595","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.595"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.595"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7301440238952637}},"branch_attrs":{"mutations":{"nuc":["A1G"]}}},{"name":"NODE_0000469","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.712774276733398}},"branch_attrs":{"mutations":{"nuc":["G6052A","G19872T","G25855T","G29254T","G29474T"],"N":["D401Y"],"ORF3a":["D155Y"]},"labels":{"aa":"N: D401Y; ORF3a: D155Y"}},"children":[{"name":"B.1.588","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.588"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.588"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{"nuc":["C7600T","G7675C","C21621T","G22201T","G28975T","G29764T"],"N":["M234I"],"S":["T20I"]},"labels":{"aa":"N: M234I; S: T20I","spike_mutations":"T20I"}}},{"name":"B.1.587","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.587"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.587"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.289678573608398}},"branch_attrs":{"mutations":{"nuc":["T5122C","G20102T","C20117T","A22095G"],"ORF1b":["S2212I","T2217I"],"S":["D178G"]},"labels":{"aa":"ORF1b: S2212I, T2217I; S: D178G","spike_mutations":"D178G"}}}]}]}]},{"name":"NODE_0000470","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.361743927001953}},"branch_attrs":{"mutations":{"nuc":["C15324T"]}},"children":[{"name":"B.1.146","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.146"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.146"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["C10833T","G28747T","G28917T","G29543T"],"N":["G215V"],"ORF1a":["A3523V"]},"labels":{"aa":"N: G215V; ORF1a: A3523V"}}},{"name":"B.1.149","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.149"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.149"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.820753574371338}},"branch_attrs":{"mutations":{"nuc":["G16846T"],"ORF1b":["D1127Y"]},"labels":{"aa":"ORF1b: D1127Y"}}},{"name":"B.1.147","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.147"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.147"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.988577127456665}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"B.1.210","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.210"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.210"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.527066707611084}},"branch_attrs":{"mutations":{"nuc":["A1C","C3634T"]}}},{"name":"B.1.212","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.212"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.212"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.869997978210449}},"branch_attrs":{"mutations":{"nuc":["C16428T"]}}},{"name":"B.1.221","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.221"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.221"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.022772789001465}},"branch_attrs":{"mutations":{"nuc":["C3602T","C6941T","C21855T","A25505G","G25906C","G25996T","C28651T","C28869T"],"N":["P199L"],"ORF1a":["H1113Y"],"ORF3a":["Q38R","G172R","V202L"],"S":["S98F"]},"labels":{"aa":"N: P199L; ORF1a: H1113Y; ORF3a: Q38R, G172R, V202L; S: S98F","spike_mutations":"S98F"}}},{"name":"B.1.219","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.219"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.219"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.373951435089111}},"branch_attrs":{"mutations":{"nuc":["T13A","C16193T","A22404T"],"ORF1b":["P909L"],"S":["E281V"]},"labels":{"aa":"ORF1b: P909L; S: E281V","spike_mutations":"E281V"}}},{"name":"B.1.620","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.620"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.620"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A22T","C1473T","G6236A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G17110T","T20049C","C21638T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21939C","T21992-","A21993-","T21994-","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","C22295T","C22498T","G22992A","G23012A","A23416T","C23604A","C24642T","G24914C","A28271T","T28297C","C28932T"],"N":["A220V"],"ORF1a":["T403I","V1991I","S3675-","G3676-","F3677-"],"ORF1b":["A1215S"],"ORF9b":["I5T"],"S":["P26S","H69-","V70-","V126A","Y144-","L241-","L242-","A243-","H245Y","S477N","E484K","P681H","T1027I","D1118H"]},"labels":{"aa":"N: A220V; ORF1a: T403I, V1991I, S3675-, G3676-, F3677-; ORF1b: A1215S; ORF9b: I5T; S: P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H","spike_mutations":"P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H"}}},{"name":"NODE_0000471","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.518583297729492}},"branch_attrs":{"mutations":{"nuc":["A4457G","C5907T","C12312T"],"ORF1a":["I1398V","T1881I","A4016V"]},"labels":{"aa":"ORF1a: I1398V, T1881I, A4016V"}},"children":[{"name":"B.1.214","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.518583297729492}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000472","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-7.461870193481445}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.214.1","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-02"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.2221879959106445}},"branch_attrs":{"mutations":{"nuc":["A481G","C5144T","C17304G","C17999T"],"ORF1b":["T1511I"]},"labels":{"aa":"ORF1b: T1511I"}}},{"name":"NODE_0000473","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C4891T","A15187G","C23709T","T27576C","G28280C","A28281T","T28282A","C28846T"],"N":["D3L"],"ORF1b":["R574G"],"S":["T716I"]},"labels":{"aa":"N: D3L; ORF1b: R574G; S: T716I","spike_mutations":"T716I"}},"children":[{"name":"B.1.214.2","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:29-276"},"partiallyAliased":{"value":"B.1.214.2"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-02"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9553585052490234}},"branch_attrs":{"mutations":{"nuc":["C22802A","T22912G","A25448-","A25449-","A25450-","T25451-","C25452-","A25453-","A25454-","G25455-","G25456-","A25457-","T25458-","G25459-","C25460-","T25461-","A25462-","C25463-","T25464-","C25465-","C25466-","T25467-","T25468-","C25469-","A25470-","G25471-","A25472-","T25473-","T25474-","T25475-"],"ORF3a":["E19-","I20-","K21-","D22-","A23-","T24-","P25-","S26-","D27-","F28-"],"S":["Q414K","N450K"]},"labels":{"aa":"ORF3a: E19-, I20-, K21-, D22-, A23-, T24-, P25-, S26-, D27-, F28-; S: Q414K, N450K","spike_mutations":"Q414K, N450K"}}},{"name":"B.1.214.3","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.214.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.214.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-01"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C673T","A11282-","G11283-","T11284-","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291T","A11430G","C21846T"],"ORF1a":["S3673-","L3674-","S3675-","G3676C","Y3722C"],"S":["T95I"]},"labels":{"aa":"ORF1a: S3673-, L3674-, S3675-, G3676C, Y3722C; S: T95I","spike_mutations":"T95I"}}}]}]}]}]},{"name":"NODE_0000474","node_attrs":{"div":7,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-3.818593740463257}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T","C28887T"],"N":["T205I"],"ORF1a":["T265I"],"ORF3a":["Q57H"]},"labels":{"aa":"N: T205I; ORF1a: T265I; ORF3a: Q57H","clade":"20C"}},"children":[{"name":"B.1.346","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.346"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.346"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["A12820G","C16762T","A17637G","C20762T"],"ORF1b":["L1099F","T2432I"]},"labels":{"aa":"ORF1b: L1099F, T2432I"}}},{"name":"B.1.433","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.433"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.433"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.620072364807129}},"branch_attrs":{"mutations":{"nuc":["C6843T","T11764C","T17040C","G29402T"],"N":["D377Y"],"ORF1a":["S2193F"]},"labels":{"aa":"N: D377Y; ORF1a: S2193F"}}},{"name":"B.1.626","node_attrs":{"div":29,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.626"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.626"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-25"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1914A","C2197T","C9142T","C9803T","C10416T","C10908T","G11222T","C13011T","C16961T","C21614T","C21758-","A21759-","T21760-","G21761-","C21762-","T21763-","A21764-","T21765-","A21766-","G22331A","G23012A","T23031C","A23064C","C24138A","T24364C","C25511T","C25583T","T26767G","C27434T","A28271-","G28280T","C29627T","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"M":["I82S"],"N":["D3Y"],"ORF1a":["R550H","S3384L","A3548V","V3653F","T4249I"],"ORF1b":["P1165L"],"ORF3a":["S40L","T64I"],"ORF7a":["T14I"],"S":["L18F","H66-","A67-","I68-","G257S","E484K","F490S","N501T","T859N"]},"labels":{"aa":"M: I82S; N: D3Y; ORF1a: R550H, S3384L, A3548V, V3653F, T4249I; ORF1b: P1165L; ORF3a: S40L, T64I; ORF7a: T14I; S: L18F, H66-, A67-, I68-, G257S, E484K, F490S, N501T, T859N","spike_mutations":"L18F, H66-, A67-, I68-, G257S, E484K, F490S, N501T, T859N"}}},{"name":"NODE_0000475","node_attrs":{"div":8,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.235102653503418}},"branch_attrs":{"mutations":{"nuc":["G17259T"],"ORF1b":["E1264D"]},"labels":{"aa":"ORF1b: E1264D"}},"children":[{"name":"B.1.375","node_attrs":{"div":14,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.375"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.375"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.301670551300049}},"branch_attrs":{"mutations":{"nuc":["T1171C","A5747G","C10789T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G24007A","C25844T","A26664G"],"M":["I48V"],"ORF1a":["T1828A"],"ORF3a":["T151I"],"S":["H69-","V70-"]},"labels":{"aa":"M: I48V; ORF1a: T1828A; ORF3a: T151I; S: H69-, V70-","spike_mutations":"H69-, V70-"}}},{"name":"B.1.596.1","node_attrs":{"div":11,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.596.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.596.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["C21780T","G25907T","G28857A"],"N":["R195K"],"ORF3a":["G172V"],"S":["T73I"]},"labels":{"aa":"N: R195K; ORF3a: G172V; S: T73I","spike_mutations":"T73I"}}}]},{"name":"NODE_0000476","node_attrs":{"div":8,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-4.433472633361816}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"B.1.630","node_attrs":{"div":36,"clade_display":{"value":"20C"},"Nextclade_pango":{"value":"B.1.630"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20C"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.630"},"totalAminoacidDeletions":{"value":14},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-13"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C629T","A1262G","C1627T","G4963T","A5040G","A5648C","C6730T","C6794T","C7768T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T17505C","C19602T","G21255T","C21588T","C21637T","G21969T","T21992-","A21993-","T21994-","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22995G","G23012C","C23525T","G24410A","C25498-","C25499-","G25500-","A25501-","T25502-","A25503-","C25504-","A25505-","A25506-","G25507-","C25508-","C25509-","T25510-","C25511-","A25512-","C25513-","T25514-","C25515-","C25516-","C25517-","T25518-","T25519-","T25520-","C25521-","T25563G","T27796C","C27889T","A28272G","C28512G","G29508A","C29739T"],"N":["P80R","S412N"],"ORF1a":["L122F","T333A","R1566S","Q1592R","K1795Q","A3209V","S3675-","G3676-","F3677-"],"ORF3a":["P36-","I37-","Q38-","A39-","S40-","L41-","P42-","F43-","H57Q"],"ORF7b":["L14S"],"ORF9b":["Q77E"],"S":["P9L","C136F","Y144-","A222V","L242-","A243-","T478R","E484Q","H655Y","D950N"]},"labels":{"aa":"N: P80R, S412N; ORF1a: L122F, T333A, R1566S, Q1592R, K1795Q, A3209V, S3675-, G3676-, F3677-; ORF3a: P36-, I37-, Q38-, A39-, S40-, L41-, P42-, F43-, H57Q; ORF7b: L14S; ORF9b: Q77E; S: P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N","spike_mutations":"P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N"}}},{"name":"21C","node_attrs":{"div":13,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["G17014T","G21600T","G22018T","C26681T","A28272T"],"ORF1b":["D1183Y"],"S":["S13I","W152C"]},"labels":{"aa":"ORF1b: D1183Y; S: S13I, W152C","clade":"Epsilon","spike_mutations":"S13I, W152C"}},"children":[{"name":"B.1.429","node_attrs":{"div":20,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1.429"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.429"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-2.493906021118164}},"branch_attrs":{"mutations":{"nuc":["C2395T","T2597C","C8947T","C12100T","A12878G","T24349C","G27890T"],"ORF1a":["I4205V"]},"labels":{"aa":"ORF1a: I4205V"}}},{"name":"B.1.427","node_attrs":{"div":17,"clade_display":{"value":"21C (Epsilon)"},"Nextclade_pango":{"value":"B.1.427"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21C"},"clade_who":{"value":"Epsilon"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.427"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"21C"},"placement_prior":{"value":-2.8388144969940186}},"branch_attrs":{"mutations":{"nuc":["G9738C","G13713A","C16394T","C29362T"],"ORF1a":["S3158T"],"ORF1b":["P976L"]},"labels":{"aa":"ORF1a: S3158T; ORF1b: P976L"}}}]}]},{"name":"NODE_0000478","node_attrs":{"div":18,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.885955572128296}},"branch_attrs":{"mutations":{"nuc":["G174T","G5230T","A10323G","A21801C","A22206G","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","G22813T","G23012A","A23063T","C23664T","C26456T","C28253T"],"E":["P71L"],"ORF1a":["K1655N","K3353R"],"S":["D80A","D215G","L241-","L242-","A243-","K417N","E484K","N501Y","A701V"]},"labels":{"aa":"E: P71L; ORF1a: K1655N, K3353R; S: D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V","clade":"Beta","spike_mutations":"D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V"}},"children":[{"name":"B.1.351.1","node_attrs":{"div":27,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-5.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["C11289G","G11291T","G11292A","T11293C","G11299T","C11300T","T11301A","A11302C","C22513A"],"ORF1a":["S3675C","G3676Y","K3678N","L3679Y"],"S":["N317K"]},"labels":{"aa":"ORF1a: S3675C, G3676Y, K3678N, L3679Y; S: N317K","spike_mutations":"N317K"}}},{"name":"NODE_0000479","node_attrs":{"div":19,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.237952470779419}},"branch_attrs":{"mutations":{"nuc":["C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}},"children":[{"name":"B.1.351","node_attrs":{"div":19,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.237952470779419}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000480","node_attrs":{"div":21,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-2.969865322113037}},"branch_attrs":{"mutations":{"nuc":["A2692T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C21614T"],"ORF1a":["S3675-","G3676-","F3677-"],"S":["L18F"]},"labels":{"aa":"ORF1a: S3675-, G3676-, F3677-; S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.351.5","node_attrs":{"div":31,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.5"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-20"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-4.056198596954346}},"branch_attrs":{"mutations":{"nuc":["C664T","G1463T","C16338T","C19019A","C24109T","C24334T","G25660A","C25844T","C26645T","A29406T"],"N":["E378V"],"ORF1a":["G400C"],"ORF1b":["P1851Q"],"ORF3a":["V90I","T151I"]},"labels":{"aa":"N: E378V; ORF1a: G400C; ORF1b: P1851Q; ORF3a: V90I, T151I"}}},{"name":"NODE_0000481","node_attrs":{"div":23,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351"},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A8052G","G10396T"],"ORF1a":["N2596S"]},"labels":{"aa":"ORF1a: N2596S"}},"children":[{"name":"B.1.351.2","node_attrs":{"div":24,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.2"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C10632T"],"ORF1a":["A3456V"]},"labels":{"aa":"ORF1a: A3456V"}}},{"name":"B.1.351.3","node_attrs":{"div":28,"clade_display":{"value":"20H (Beta)"},"Nextclade_pango":{"value":"B.1.351.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20H"},"clade_who":{"value":"Beta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.351.3"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-05"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20H"},"placement_prior":{"value":-4.0184102058410645}},"branch_attrs":{"mutations":{"nuc":["T3G","C6402T","T7624C","C10615T","A16687G"],"ORF1a":["P2046L"],"ORF1b":["I1074V"]},"labels":{"aa":"ORF1a: P2046L; ORF1b: I1074V"}}}]}]}]}]}]},{"name":"NODE_0000482","node_attrs":{"div":11,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.10436749458313}},"branch_attrs":{"mutations":{"nuc":["T445C","C6286T","G21255C","C22227T","C26801G","C28932T","G29645T"],"N":["A220V"],"S":["A222V"]},"labels":{"aa":"N: A220V; S: A222V","clade":"20E","spike_mutations":"A222V"}},"children":[{"name":"B.1.177","node_attrs":{"div":11,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.10436749458313}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.16","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.051562786102295}},"branch_attrs":{"mutations":{"nuc":["C28310A"],"N":["P13T"],"ORF9b":["H9Q"]},"labels":{"aa":"N: P13T; ORF9b: H9Q"}}},{"name":"B.1.177.18","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.176742076873779}},"branch_attrs":{"mutations":{"nuc":["A10323G","G23311C","G25440T","C27752T"],"ORF1a":["K3353R"],"ORF3a":["K16N"],"ORF7a":["T120I"],"S":["E583D"]},"labels":{"aa":"ORF1a: K3353R; ORF3a: K16N; ORF7a: T120I; S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.177.15","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.15"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.15"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.8122081756591797}},"branch_attrs":{"mutations":{"nuc":["C5170T","C10078T","G11132T","G11417T","G22051T","G29179T"],"ORF1a":["A3623S","V3718F"]},"labels":{"aa":"ORF1a: A3623S, V3718F"}}},{"name":"B.1.177.32","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.32"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.204561233520508}},"branch_attrs":{"mutations":{"nuc":["C5700T","C11152T"],"ORF1a":["A1812V"]},"labels":{"aa":"ORF1a: A1812V"}}},{"name":"B.1.177.73","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.73"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.0868425369262695}},"branch_attrs":{"mutations":{"nuc":["G1820A","A2473G","T7543C","C13671T","A24774T","C26060A"],"ORF1a":["G519S"],"ORF3a":["T223N"],"S":["Q1071L"]},"labels":{"aa":"ORF1a: G519S; ORF3a: T223N; S: Q1071L","spike_mutations":"Q1071L"}}},{"name":"B.1.177.75","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.75"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.15676212310791}},"branch_attrs":{"mutations":{"nuc":["A1C","T8284C"]}}},{"name":"NODE_0000483","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.143002986907959}},"branch_attrs":{"mutations":{"nuc":["C222T","T20661C","C29386T"]}},"children":[{"name":"B.1.177.44","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.44"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.074657917022705}},"branch_attrs":{"mutations":{"nuc":["G21468T"],"ORF1b":["M2667I"]},"labels":{"aa":"ORF1b: M2667I"}}},{"name":"NODE_0000484","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.473905324935913}},"branch_attrs":{"mutations":{"nuc":["C29366T"],"N":["P365S"]},"labels":{"aa":"N: P365S"}},"children":[{"name":"B.1.177.12","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.12"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.12"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.395730495452881}},"branch_attrs":{"mutations":{"nuc":["T24814C","G25757T"],"ORF3a":["R122I"]},"labels":{"aa":"ORF3a: R122I"}}},{"name":"B.1.177.35","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.877903938293457}},"branch_attrs":{"mutations":{"nuc":["T26966C"]}}}]}]},{"name":"NODE_0000485","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.9249725341796875}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}},"children":[{"name":"B.1.177.10","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.106119155883789}},"branch_attrs":{"mutations":{"nuc":["G28321A"],"ORF9b":["R13H"]},"labels":{"aa":"ORF9b: R13H"}}},{"name":"B.1.177.46","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.46"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.155553817749023}},"branch_attrs":{"mutations":{"nuc":["C9693T","C18508T","G29179T"],"ORF1a":["A3143V"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: A3143V; ORF1b: L1681F"}}},{"name":"NODE_0000486","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.44374942779541}},"branch_attrs":{"mutations":{"nuc":["C1513T","C22377T"],"S":["P272L"]},"labels":{"aa":"S: P272L","spike_mutations":"P272L"}},"children":[{"name":"B.1.177.82","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.82"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.837984561920166}},"branch_attrs":{"mutations":{"nuc":["G28378T","G29757T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.177.83","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.83"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.299724102020264}},"branch_attrs":{"mutations":{"nuc":["C2062T"]}}},{"name":"B.1.177.87","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.87"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.936094045639038}},"branch_attrs":{"mutations":{"nuc":["C28706T","C29095T"],"N":["H145Y"]},"labels":{"aa":"N: H145Y"}}}]}]},{"name":"NODE_0000487","node_attrs":{"div":12,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.161720037460327}},"branch_attrs":{"mutations":{"nuc":["C27944T"]}},"children":[{"name":"B.1.177.4","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.478666067123413}},"branch_attrs":{"mutations":{"nuc":["C66T","A1987G","G10870T","C25614T"]}}},{"name":"B.1.177.52","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.52"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.295442581176758}},"branch_attrs":{"mutations":{"nuc":["A1T","G5023T","C25047G"],"ORF1a":["M1586I"],"S":["P1162R"]},"labels":{"aa":"ORF1a: M1586I; S: P1162R","spike_mutations":"P1162R"}}},{"name":"B.1.177.81","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.81"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.399031639099121}},"branch_attrs":{"mutations":{"nuc":["C12119T","A21222T","C25889T"],"ORF1a":["P3952S"],"ORF3a":["S166L"]},"labels":{"aa":"ORF1a: P3952S; ORF3a: S166L"}}},{"name":"NODE_0000488","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.53"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.278008460998535}},"branch_attrs":{"mutations":{"nuc":["C2973T","G9805T"],"ORF1a":["A903V"]},"labels":{"aa":"ORF1a: A903V"}},"children":[{"name":"B.1.177.53","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.53"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.278008460998535}},"branch_attrs":{"mutations":{}}},{"name":"W.1","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"W.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.53.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-5.000475883483887}},"branch_attrs":{"mutations":{"nuc":["C17463T","C17676T","T24799C","G25785T"],"ORF3a":["W131C"]},"labels":{"aa":"ORF3a: W131C"}}}]},{"name":"NODE_0000489","node_attrs":{"div":13,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.131291389465332}},"branch_attrs":{"mutations":{"nuc":["G204T"]}},"children":[{"name":"B.1.177.21","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.21"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.21"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.0787036418914795}},"branch_attrs":{"mutations":{"nuc":["T16242A"]}}},{"name":"B.1.177.77","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.77"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.045211315155029}},"branch_attrs":{"mutations":{"nuc":["T3592C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"NODE_0000490","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.644140243530273}},"branch_attrs":{"mutations":{"nuc":["C9745T"]}},"children":[{"name":"B.1.177.54","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.54"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.9744465351104736}},"branch_attrs":{"mutations":{"nuc":["C23644T","T25878C","G25879A","A25881T"],"ORF3a":["V163I"]},"labels":{"aa":"ORF3a: V163I"}}},{"name":"NODE_0000491","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.353252410888672}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"ORF1a":["A2554V"]},"labels":{"aa":"ORF1a: A2554V"}},"children":[{"name":"B.1.177.56","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.56"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.353252410888672}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.57","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.57"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.707308292388916}},"branch_attrs":{"mutations":{"nuc":["C6807T"],"ORF1a":["T2181I"]},"labels":{"aa":"ORF1a: T2181I"}}}]}]},{"name":"NODE_0000492","node_attrs":{"div":14,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177"},"clade_membership":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-2.56699800491333}},"branch_attrs":{"mutations":{"nuc":["C21614T"],"S":["L18F"]},"labels":{"aa":"S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.177.5","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.151096820831299}},"branch_attrs":{"mutations":{"nuc":["T24769C","C25460T"],"ORF3a":["A23V"]},"labels":{"aa":"ORF3a: A23V"}}},{"name":"B.1.177.60","node_attrs":{"div":16,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.60"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.3496036529541016}},"branch_attrs":{"mutations":{"nuc":["A1G","G25621T"],"ORF3a":["V77F"]},"labels":{"aa":"ORF3a: V77F"}}},{"name":"B.1.177.62","node_attrs":{"div":18,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.62"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.26824951171875}},"branch_attrs":{"mutations":{"nuc":["C7195T","C21714T","G24368T","G25855T"],"ORF3a":["D155Y"],"S":["T51I","D936Y"]},"labels":{"aa":"ORF3a: D155Y; S: T51I, D936Y","spike_mutations":"T51I, D936Y"}}},{"name":"B.1.177.7","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.7"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.4441723823547363}},"branch_attrs":{"mutations":{"nuc":["C15480T"]}}},{"name":"B.1.177.8","node_attrs":{"div":15,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-4.112912654876709}},"branch_attrs":{"mutations":{"nuc":["G8179T"]}}},{"name":"B.1.177.86","node_attrs":{"div":17,"clade_display":{"value":"20E"},"Nextclade_pango":{"value":"B.1.177.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20E"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.177.86"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20E"},"placement_prior":{"value":-3.4548091888427734}},"branch_attrs":{"mutations":{"nuc":["C6040T","G26801T","G27870T"],"ORF7b":["E39*"]},"labels":{"aa":"ORF7b: E39*"}}}]}]}]}]},{"name":"NODE_0000493","node_attrs":{"div":5,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.2655062675476074}},"branch_attrs":{"mutations":{"nuc":["A20268G"]}},"children":[{"name":"B.1.189","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.189"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.189"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0477776527404785}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.192","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.192"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.192"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.362252235412598}},"branch_attrs":{"mutations":{"nuc":["C11833T"]}}},{"name":"B.1.237","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.237"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.237"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.8359174728393555}},"branch_attrs":{"mutations":{"nuc":["G2164C"],"ORF1a":["E633D"]},"labels":{"aa":"ORF1a: E633D"}}},{"name":"B.1.381","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.381"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.381"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.034161567687988}},"branch_attrs":{"mutations":{"nuc":["C355T","C4093T"]}}},{"name":"B.1.420","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.420"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.420"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.049466133117676}},"branch_attrs":{"mutations":{"nuc":["T23443C"]}}},{"name":"B.1.417","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.417"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.417"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.064149856567383}},"branch_attrs":{"mutations":{"nuc":["T5422C","C7051T","G7743T","C12880T"],"ORF1a":["S2493I"]},"labels":{"aa":"ORF1a: S2493I"}}},{"name":"B.1.609","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.609"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.609"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":2},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.865211248397827}},"branch_attrs":{"mutations":{"nuc":["C4582T"]}}},{"name":"B.1.600","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.600"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.600"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.995730876922607}},"branch_attrs":{"mutations":{"nuc":["A5G","A6G","G7A","C5784T","C27982T"],"ORF1a":["T1840I"],"ORF8":["P30L"]},"labels":{"aa":"ORF1a: T1840I; ORF8: P30L"}}},{"name":"NODE_0000494","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.637956142425537}},"branch_attrs":{"mutations":{"nuc":["A1C","C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}},"children":[{"name":"B.1.416","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.416"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.27862024307251}},"branch_attrs":{"mutations":{"nuc":["C1625T"],"ORF1a":["L454F"]},"labels":{"aa":"ORF1a: L454F"}}},{"name":"B.1.416.1","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.416.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.416.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.302814483642578}},"branch_attrs":{"mutations":{"nuc":["C25731T"]}}}]},{"name":"NODE_0000495","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{"nuc":["A1G","T7767C","C8047T","C17104T","C22879A","G29734C"],"ORF1a":["I2501T"],"ORF1b":["H1213Y"],"S":["N439K"]},"labels":{"aa":"ORF1a: I2501T; ORF1b: H1213Y; S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.258","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0006608963012695}},"branch_attrs":{"mutations":{}}},{"name":"B.1.258.3","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9645659923553467}},"branch_attrs":{"mutations":{"nuc":["G1464A","A10978T","G18803T","T20799C"],"ORF1a":["G400D"],"ORF1b":["S1779I"]},"labels":{"aa":"ORF1a: G400D; ORF1b: S1779I"}}},{"name":"NODE_0000496","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9934825897216797}},"branch_attrs":{"mutations":{"nuc":["C27800A"]}},"children":[{"name":"B.1.258.14","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.14"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.14"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.224915027618408}},"branch_attrs":{"mutations":{"nuc":["G1A","C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}}},{"name":"NODE_0000497","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.193143367767334}},"branch_attrs":{"mutations":{"nuc":["G12988T","G15598A","G18028T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T24910C","T26972C"],"ORF1a":["M4241I"],"ORF1b":["V711I","A1521S"],"S":["H69-","V70-"]},"labels":{"aa":"ORF1a: M4241I; ORF1b: V711I, A1521S; S: H69-, V70-","spike_mutations":"H69-, V70-"}},"children":[{"name":"B.1.258.11","node_attrs":{"div":19,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.11"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.11"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.367208242416382}},"branch_attrs":{"mutations":{"nuc":["C12455T","C20451T"],"ORF1a":["L4064F"]},"labels":{"aa":"ORF1a: L4064F"}}},{"name":"B.1.258.17","node_attrs":{"div":25,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.258.17"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.258.17"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.194498300552368}},"branch_attrs":{"mutations":{"nuc":["C829T","C14697T","C16394T","C18176T","G19398T","C22127T","G23876A","G25947T"],"ORF1b":["P976L","P1570L","E1977D"],"ORF3a":["Q185H"],"S":["L189F","V772I"]},"labels":{"aa":"ORF1b: P976L, P1570L, E1977D; ORF3a: Q185H; S: L189F, V772I","spike_mutations":"L189F, V772I"}}}]}]}]},{"name":"NODE_0000498","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.0564932823181152}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.232","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.232"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.232"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8151824474334717}},"branch_attrs":{"mutations":{"nuc":["G27987T"],"ORF8":["V32L"]},"labels":{"aa":"ORF8: V32L"}}},{"name":"B.1.236","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.236"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.236"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.487241744995117}},"branch_attrs":{"mutations":{"nuc":["G11842A","A12759G","G18292T"],"ORF1a":["D4165G"],"ORF1b":["A1609S"]},"labels":{"aa":"ORF1a: D4165G; ORF1b: A1609S"}}},{"name":"B.1.234","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.234"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.234"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.2366039752960205}},"branch_attrs":{"mutations":{"nuc":["G2258A","A6441G","C8140T","A9204G"],"ORF1a":["V665I","K2059R","D2980G"]},"labels":{"aa":"ORF1a: V665I, K2059R, D2980G"}}},{"name":"B.1.239","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.239"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.239"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.171220779418945}},"branch_attrs":{"mutations":{"nuc":["G16741A"],"ORF1b":["V1092I"]},"labels":{"aa":"ORF1b: V1092I"}}},{"name":"B.1.243","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.243"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.243"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.002568006515503}},"branch_attrs":{"mutations":{"nuc":["T24076C"]}}},{"name":"B.1.241","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.241"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.241"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9270756244659424}},"branch_attrs":{"mutations":{"nuc":["C11575T"]}}},{"name":"B.1.398","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.398"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.398"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.523491859436035}},"branch_attrs":{"mutations":{"nuc":["G4136A","C11224T","C12295A","C21846T"],"ORF1a":["V1291I"],"S":["T95I"]},"labels":{"aa":"ORF1a: V1291I; S: T95I","spike_mutations":"T95I"}}},{"name":"B.1.396","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.396"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.396"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1255927085876465}},"branch_attrs":{"mutations":{"nuc":["C1191T","C9521A","C24904T","G29422T","A29567G"],"ORF1a":["P309L","L3086I"]},"labels":{"aa":"ORF1a: P309L, L3086I"}}},{"name":"B.1.397","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.397"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.397"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.8025803565979}},"branch_attrs":{"mutations":{"nuc":["G1135T"],"ORF1a":["K290N"]},"labels":{"aa":"ORF1a: K290N"}}},{"name":"B.1.400","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.400"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.400"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.656111001968384}},"branch_attrs":{"mutations":{"nuc":["G19969A"],"ORF1b":["A2168T"]},"labels":{"aa":"ORF1b: A2168T"}}},{"name":"B.1.399","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.399"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.399"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.259310722351074}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}}},{"name":"B.1.409","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.409"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.409"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.119840621948242}},"branch_attrs":{"mutations":{"nuc":["G3527A","G5015A","A5877G","G8017T","C11008T","C20283T","C25714T","G25855T","C27434T","C27998T"],"ORF1a":["D1088N","V1584M","N1871S"],"ORF3a":["L108F","D155Y"],"ORF7a":["T14I"]},"labels":{"aa":"ORF1a: D1088N, V1584M, N1871S; ORF3a: L108F, D155Y; ORF7a: T14I"}}},{"name":"B.1.402","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.402"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.402"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.0817766189575195}},"branch_attrs":{"mutations":{"nuc":["C4633T","T14643C","C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"B.1.551","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.551"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.551"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.050684928894043}},"branch_attrs":{"mutations":{"nuc":["C3738T","C23604G"],"ORF1a":["P1158L"],"S":["P681R"]},"labels":{"aa":"ORF1a: P1158L; S: P681R","spike_mutations":"P681R"}}},{"name":"B.1.558","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.558"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.558"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.163711071014404}},"branch_attrs":{"mutations":{"nuc":["C1288T"]}}},{"name":"NODE_0000499","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6818833351135254}},"branch_attrs":{"mutations":{"nuc":["C18486T","T22162C"]}},"children":[{"name":"B.1.240","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.240"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6818833351135254}},"branch_attrs":{"mutations":{}}},{"name":"B.1.240.1","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.240.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.240.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-8.3259916305542}},"branch_attrs":{"mutations":{"nuc":["G10610T","G10870T","G11335T","C14262T","G29494A"],"ORF1a":["V3449F"]},"labels":{"aa":"ORF1a: V3449F"}}}]},{"name":"NODE_0000500","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.489668369293213}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"B.1.404","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.404"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.404"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["G5572T","G7042T","A12644G","T16743C","G19086T","G22992A"],"ORF1a":["M1769I","M2259I","I4127V"],"ORF1b":["K1873N"],"S":["S477N"]},"labels":{"aa":"ORF1a: M1769I, M2259I, I4127V; ORF1b: K1873N; S: S477N","spike_mutations":"S477N"}}},{"name":"B.1.561","node_attrs":{"div":13,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.561"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.561"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.6974472999572754}},"branch_attrs":{"mutations":{"nuc":["G2516T","A5999G","C18693T","G21974T","T25577C","G28975T"],"N":["M234I"],"ORF1a":["V751L","I1912V"],"ORF3a":["I62T"],"S":["D138Y"]},"labels":{"aa":"N: M234I; ORF1a: V751L, I1912V; ORF3a: I62T; S: D138Y","spike_mutations":"D138Y"}}}]}]}]},{"name":"NODE_0000501","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.725203275680542}},"branch_attrs":{"mutations":{"nuc":["C18877T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.111","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.111"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.111"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.209517478942871}},"branch_attrs":{"mutations":{"nuc":["C10507T"]}}},{"name":"B.1.170","node_attrs":{"div":6,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.170"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.170"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.725203275680542}},"branch_attrs":{"mutations":{}}},{"name":"B.1.436","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.436"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.436"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.123165607452393}},"branch_attrs":{"mutations":{"nuc":["C28890T","T29710A"],"N":["S206F"]},"labels":{"aa":"N: S206F"}}},{"name":"B.1.438","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.438"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.438"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.653039455413818}},"branch_attrs":{"mutations":{"nuc":["A1154G","G29474T"],"N":["D401Y"],"ORF1a":["M297V"]},"labels":{"aa":"N: D401Y; ORF1a: M297V"}}},{"name":"B.1.441","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.441"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.441"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.796085357666016}},"branch_attrs":{"mutations":{"nuc":["T8296C","G28690T"],"N":["L139F"]},"labels":{"aa":"N: L139F"}}},{"name":"NODE_0000502","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.096360206604004}},"branch_attrs":{"mutations":{"nuc":["A28272G","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}},"children":[{"name":"B.1.438.1","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.438.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.438.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.225435256958008}},"branch_attrs":{"mutations":{"nuc":["A1154G","C8152T","A12121G","G23587T","G25677T","G29474T"],"N":["D401Y"],"ORF1a":["M297V"],"ORF3a":["L95F"],"S":["Q675H"]},"labels":{"aa":"N: D401Y; ORF1a: M297V; ORF3a: L95F; S: Q675H","spike_mutations":"Q675H"}}},{"name":"B.1.625","node_attrs":{"div":26,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.625"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:4-122"},"partiallyAliased":{"value":"B.1.625"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-19"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["G521T","C2306T","A4220G","C5730T","C6401T","A10323G","C10775T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12730G","A13712G","C16694T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","T21992-","A21993-","T21994-","C22033A","T22882G","G23012A","G24410A","G25244T","T26767C","A27721G","A27897-","A27898-","A27899-","T27900-","T27901-"],"M":["I82T"],"ORF1a":["V86F","L681F","K1319E","T1822I","P2046S","K3353R","P3504S","S3675-","G3676-","F3677-"],"ORF1b":["K82R","T1076I"],"ORF7a":["I110V"],"ORF8":["K2-","F3-"],"S":["H69-","V70-","T95I","Y144-","F157L","N440K","E484K","D950N","V1228L"]},"labels":{"aa":"M: I82T; ORF1a: V86F, L681F, K1319E, T1822I, P2046S, K3353R, P3504S, S3675-, G3676-, F3677-; ORF1b: K82R, T1076I; ORF7a: I110V; ORF8: K2-, F3-; S: H69-, V70-, T95I, Y144-, F157L, N440K, E484K, D950N, V1228L","spike_mutations":"H69-, V70-, T95I, Y144-, F157L, N440K, E484K, D950N, V1228L"}}}]},{"name":"NODE_0000503","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.250260353088379}},"branch_attrs":{"mutations":{"nuc":["C7765T","C17690T"],"ORF1b":["S1408L"]},"labels":{"aa":"ORF1b: S1408L"}},"children":[{"name":"B.1.9.5","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9.5"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.9.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.250260353088379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.9","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.9"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.9"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.655849933624268}},"branch_attrs":{"mutations":{"nuc":["C2113T"]}}}]},{"name":"NODE_0000504","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-6.290716171264648}},"branch_attrs":{"mutations":{"nuc":["C10029T","A21993-","A23063T","C23604A","A26492T","C28887T"],"N":["T205I"],"ORF1a":["T3255I"],"S":["Y144-","N501Y","P681H"]},"labels":{"aa":"N: T205I; ORF1a: T3255I; S: Y144-, N501Y, P681H","spike_mutations":"Y144-, N501Y, P681H"}},"children":[{"name":"B.1.640.1","node_attrs":{"div":46,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.640.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.640.1"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C601T","C1191T","A1620G","C2416T","C2455T","G6622T","C9711T","G9756A","T11418C","C11956T","C16575T","C16869T","T18877C","C20283T","C21588T","G21848C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","T21994-","G22132T","T22191C","A22600C","A22743G","T22907A","T23030C","T23031G","C24138A","G24368C","C25487T","T26767C","C27513T","C27807T","C27972T","A28271-","T28297C","G28337T","T29377C","G29405C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","G29779T"],"M":["I82T"],"N":["D22Y","E378Q"],"ORF1a":["P309L","E452G","L2119F","S3149F","R3164H","V3718A"],"ORF3a":["T32I"],"ORF8":["Q27*"],"ORF9b":["I5T","Q18H"],"S":["P9L","E96Q","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","R190S","I210T","R346S","N394S","Y449N","F490R","T859N","D936H"]},"labels":{"aa":"M: I82T; N: D22Y, E378Q; ORF1a: P309L, E452G, L2119F, S3149F, R3164H, V3718A; ORF3a: T32I; ORF8: Q27*; ORF9b: I5T, Q18H; S: P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, R190S, I210T, R346S, N394S, Y449N, F490R, T859N, D936H","spike_mutations":"P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, R190S, I210T, R346S, N394S, Y449N, F490R, T859N, D936H"}}},{"name":"NODE_0000505","node_attrs":{"div":29,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-3.4022557735443115}},"branch_attrs":{"mutations":{"nuc":["A3428G","C4878T","C6037T","A11451G","A13057T","C17491T","T19035C","C20148T","C21846T","-21993C","T21995A","G22599A","G23012A","G24410A","G26158-","T26159-","T26160-","A26161-","C27925A","C28005T","C28093T","A28272T"],"ORF1a":["T1055A","T1538I","Q3729R"],"ORF1b":["P1342S"],"ORF3a":["V256-","N257-"],"ORF8":["T11K","P38S","S67F"],"S":["T95I","-144S","Y145N","R346K","E484K","D950N"]},"labels":{"aa":"ORF1a: T1055A, T1538I, Q3729R; ORF1b: P1342S; ORF3a: V256-, N257-; ORF8: T11K, P38S, S67F; S: T95I, -144S, Y145N, R346K, E484K, D950N","clade":"Mu","spike_mutations":"T95I, -144S, Y145N, R346K, E484K, D950N"}},"children":[{"name":"B.1.621","node_attrs":{"div":29,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-23"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-3.4022557735443115}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":31,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.116074562072754}},"branch_attrs":{"mutations":{"nuc":["C5192T","C17707T"],"ORF1b":["P1414S"]},"labels":{"aa":"ORF1b: P1414S"}},"children":[{"name":"B.1.621.2","node_attrs":{"div":39,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-05"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["T177C","C2700T","T22907A","G23311T","G26959A","A27675C","G29736A","G29779T"],"M":["R146H"],"ORF1a":["T812I"],"ORF7a":["Q94H"],"S":["Y449N","E583D"]},"labels":{"aa":"M: R146H; ORF1a: T812I; ORF7a: Q94H; S: Y449N, E583D","spike_mutations":"Y449N, E583D"}}},{"name":"NODE_0000507","node_attrs":{"div":38,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.1"},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{"nuc":["A6704G","C9120T","C20402T","T22384A","G26167T","C28657T","T29748C"],"ORF1a":["N2147D","T2952I"],"ORF1b":["S2312L"]},"labels":{"aa":"ORF1a: N2147D, T2952I; ORF1b: S2312L"}},"children":[{"name":"B.1.621.1","node_attrs":{"div":38,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"B.1.621.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.1"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-30"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{}}},{"name":"BB.2","node_attrs":{"div":42,"clade_display":{"value":"21H (Mu)"},"Nextclade_pango":{"value":"BB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21H"},"clade_who":{"value":"Mu"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF3a:258-276"},"partiallyAliased":{"value":"B.1.621.1.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21H"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A6708G","C15963T","C24378T","C29409T"],"N":["T379I"],"ORF1a":["K2148R"],"S":["S939F"]},"labels":{"aa":"N: T379I; ORF1a: K2148R; S: S939F","spike_mutations":"S939F"}}}]}]}]}]},{"name":"NODE_0000508","node_attrs":{"div":7,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.0052971839904785}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}},"children":[{"name":"B.1.465","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.465"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.465"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.766111373901367}},"branch_attrs":{"mutations":{"nuc":["G24197T"],"S":["A879S"]},"labels":{"aa":"S: A879S","spike_mutations":"A879S"}}},{"name":"B.1.462","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.462"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.462"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.589012622833252}},"branch_attrs":{"mutations":{"nuc":["C3811T"]}}},{"name":"B.1.468","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.468"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.468"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.633845806121826}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}}},{"name":"B.1.470","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.470"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.470"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.864387512207031}},"branch_attrs":{"mutations":{"nuc":["C14120T"],"ORF1b":["P218L"]},"labels":{"aa":"ORF1b: P218L"}}},{"name":"B.1.471","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.471"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.471"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.839450836181641}},"branch_attrs":{"mutations":{"nuc":["C16915T","T24202C"]}}},{"name":"B.1.469","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.469"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.469"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.699270725250244}},"branch_attrs":{"mutations":{"nuc":["A12075G","A21137G","C28866T"],"N":["T198I"],"ORF1a":["N3937S"],"ORF1b":["K2557R"]},"labels":{"aa":"N: T198I; ORF1a: N3937S; ORF1b: K2557R"}}},{"name":"B.1.523","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.523"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.523"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.353262901306152}},"branch_attrs":{"mutations":{"nuc":["G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"NODE_0000509","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.896757125854492}},"branch_attrs":{"mutations":{"nuc":["C4543T","G5629T","G9526T","C11497T","G13993T","G15766T","A16889G","G17019T","G22992A","C25710T","T26876C","G28975C","G29399A"],"N":["M234I","A376T"],"ORF1a":["M3087I"],"ORF1b":["A176S","V767L","K1141R","E1184D"],"S":["S477N"]},"labels":{"aa":"N: M234I, A376T; ORF1a: M3087I; ORF1b: A176S, V767L, K1141R, E1184D; S: S477N","spike_mutations":"S477N"}},"children":[{"name":"B.1.160","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.160"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-2.896757125854492}},"branch_attrs":{"mutations":{}}},{"name":"B.1.160.16","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.160.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.160.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.024462699890137}},"branch_attrs":{"mutations":{"nuc":["C27434T","C27964T","G29557T"],"ORF7a":["T14I"],"ORF8":["S24L"]},"labels":{"aa":"ORF7a: T14I; ORF8: S24L"}}}]},{"name":"NODE_0000510","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.83497428894043}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.466.1","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["A3423G","C6318A","C15026T","A19960G","C22879A","G25526T","C25553T","C26111T","A29019G","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K249R"],"ORF1a":["K1053R","P2018Q"],"ORF1b":["A520V","T2165A"],"ORF3a":["W45L","A54V","P240L"],"S":["N439K"]},"labels":{"aa":"N: K249R; ORF1a: K1053R, P2018Q; ORF1b: A520V, T2165A; ORF3a: W45L, A54V, P240L; S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.466","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.83497428894043}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000511","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.037178993225098}},"branch_attrs":{"mutations":{"nuc":["C5184T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"B.1.459","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.459"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.459"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.037178993225098}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000512","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.371043682098389}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22879A","C28887T"],"N":["T205I"],"ORF1a":["T1168I"],"S":["N439K"]},"labels":{"aa":"N: T205I; ORF1a: T1168I; S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.466.2","node_attrs":{"div":15,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.371043682098389}},"branch_attrs":{"mutations":{"nuc":["A29897T","A29898G","A29899G","A29902G"]}}},{"name":"NODE_0000513","node_attrs":{"div":20,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.466.2"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.7382190227508545}},"branch_attrs":{"mutations":{"nuc":["C683T","C3096T","C11195T","C12880T","C17012T","T22219C","C23604G","C29718T","C29743T"],"ORF1a":["S944L","L3644F"],"ORF1b":["S1182L"],"S":["P681R"]},"labels":{"aa":"ORF1a: S944L, L3644F; ORF1b: S1182L; S: P681R","spike_mutations":"P681R"}},"children":[{"name":"AU.2","node_attrs":{"div":24,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"AU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-30"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.538212776184082}},"branch_attrs":{"mutations":{"nuc":["A11117G","C12439T","G20002T","G25314T"],"ORF1a":["I3618V"],"ORF1b":["D2179Y"],"S":["G1251V"]},"labels":{"aa":"ORF1a: I3618V; ORF1b: D2179Y; S: G1251V","spike_mutations":"G1251V"}}},{"name":"AU.3","node_attrs":{"div":23,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"AU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.466.2.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-30"},"totalAminoacidSubstitutions":{"value":14},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.585629463195801}},"branch_attrs":{"mutations":{"nuc":["C8109T","C19586T","G29315C"],"N":["D348H"],"ORF1a":["T2615I"],"ORF1b":["T2040I"]},"labels":{"aa":"N: D348H; ORF1a: T2615I; ORF1b: T2040I"}}}]}]}]},{"name":"NODE_0000514","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.642129898071289}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36.19","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.19"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.19"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.078061103820801}},"branch_attrs":{"mutations":{"nuc":["A1C","G28086T","C29614T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"B.1.456","node_attrs":{"div":8,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.456"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.456"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.642129898071289}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000515","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}},"children":[{"name":"B.1.36","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.1","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.350651741027832}},"branch_attrs":{"mutations":{"nuc":["C11224T","C11941T","C12043T"]}}},{"name":"B.1.36.10","node_attrs":{"div":9,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9620213508605957}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.16","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.127452373504639}},"branch_attrs":{"mutations":{"nuc":["A1T","G25494T"]}}},{"name":"B.1.36.22","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.22"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.22"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.1283345222473145}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"B.1.36.29","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.29"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8214738368988037}},"branch_attrs":{"mutations":{"nuc":["C3267T","C21034T","G26173T","G28183T","T28277C"],"N":["S2P"],"ORF1a":["T1001I"],"ORF1b":["L2523F"],"ORF3a":["E261*"],"ORF8":["S97I"]},"labels":{"aa":"N: S2P; ORF1a: T1001I; ORF1b: L2523F; ORF3a: E261*; ORF8: S97I"}}},{"name":"B.1.36.24","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.24"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.24"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.737071990966797}},"branch_attrs":{"mutations":{"nuc":["G22201T"]}}},{"name":"B.1.36.31","node_attrs":{"div":21,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.31"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1722T","A8512G","T9877C","G11222T","C12616T","C15738T","A21868T","C22227T","C25463T","G27561T","C28253T","C29095T"],"ORF1a":["A486V","V3653F"],"ORF3a":["T24I"],"S":["R102S","A222V"]},"labels":{"aa":"ORF1a: A486V, V3653F; ORF3a: T24I; S: R102S, A222V","spike_mutations":"R102S, A222V"}}},{"name":"B.1.36.35","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.654303073883057}},"branch_attrs":{"mutations":{"nuc":["G25440T"],"ORF3a":["K16N"]},"labels":{"aa":"ORF3a: K16N"}}},{"name":"B.1.36.7","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.7"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.544944763183594}},"branch_attrs":{"mutations":{"nuc":["A11211G","A22190-","T22191-","T22192-"],"ORF1a":["Y3649C"],"S":["I210-"]},"labels":{"aa":"ORF1a: Y3649C; S: I210-","spike_mutations":"I210-"}}},{"name":"B.1.36.8","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.073090076446533}},"branch_attrs":{"mutations":{"nuc":["A1T","C2836T"]}}},{"name":"B.1.36.9","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.9"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.9"},"totalAminoacidDeletions":{"value":1},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["G2035T","C2523T","G3994A","C5730T","C9924T","G11083T","C11109T","A22190-","T22191-","T22192-","C24138A"],"ORF1a":["L590F","T753I","T1822I","A3220V","L3606F","A3615V"],"S":["I210-","T859N"]},"labels":{"aa":"ORF1a: L590F, T753I, T1822I, A3220V, L3606F, A3615V; S: I210-, T859N","spike_mutations":"I210-, T859N"}}},{"name":"NODE_0000516","node_attrs":{"div":10,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.4276256561279297}},"branch_attrs":{"mutations":{"nuc":["T1947C"],"ORF1a":["V561A"]},"labels":{"aa":"ORF1a: V561A"}},"children":[{"name":"B.1.36.36","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8934714794158936}},"branch_attrs":{"mutations":{"nuc":["C2668T","G4136T","C12141T","C19512T","C28292A","G29179T"],"N":["Q7K"],"ORF1a":["V1291F","T3959I"]},"labels":{"aa":"N: Q7K; ORF1a: V1291F, T3959I"}}},{"name":"B.1.36.38","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.38"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.2723917961120605}},"branch_attrs":{"mutations":{"nuc":["G22918T"]}}},{"name":"NODE_0000517","node_attrs":{"div":11,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-5.259945392608643}},"branch_attrs":{"mutations":{"nuc":["C29555T"]}},"children":[{"name":"B.1.36.18","node_attrs":{"div":16,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.18"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.18"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.8423047065734863}},"branch_attrs":{"mutations":{"nuc":["G8027T","G15438T","C18981T","G21785C","C28093T"],"ORF1a":["V2588F"],"ORF1b":["M657I"],"ORF8":["S67F"],"S":["G75R"]},"labels":{"aa":"ORF1a: V2588F; ORF1b: M657I; ORF8: S67F; S: G75R","spike_mutations":"G75R"}}},{"name":"NODE_0000518","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}},"children":[{"name":"B.1.36.17","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.17"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.17"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.39","node_attrs":{"div":17,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.36.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.36.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2319C","C6573T","C9936A","C15981T","C25904T"],"ORF1a":["F685S","S2103F","T3224N"],"ORF3a":["S171L"]},"labels":{"aa":"ORF1a: F685S, S2103F, T3224N; ORF3a: S171L"}}}]}]}]}]}]}]}]},{"name":"NODE_0000519","node_attrs":{"div":12,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-3.9009342193603516}},"branch_attrs":{"mutations":{"nuc":["G210T","T22917G","C23604G","T27638C","G28881T","G29402T","G29742T"],"N":["R203M","D377Y"],"ORF7a":["V82A"],"S":["T19R","L452R","P681R"]},"labels":{"aa":"N: R203M, D377Y; ORF7a: V82A; S: T19R, L452R, P681R","spike_mutations":"T19R, L452R, P681R"}},"children":[{"name":"B.1.617.3","node_attrs":{"div":22,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20A"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["C835T","C7296T","C8208T","G10634T","C11322T","C16293T","C21618G","G23012C","T27384C","C27970T","C28472T"],"N":["P67S"],"ORF1a":["A2344V","T2648I","A3457S","A3686V"],"ORF8":["T26I"],"S":["E484Q"]},"labels":{"aa":"N: P67S; ORF1a: A2344V, T2648I, A3457S, A3686V; ORF8: T26I; S: E484Q","spike_mutations":"E484Q"}}},{"name":"internal_d736","node_attrs":{"div":14,"clade_display":{"value":"20A"},"Nextclade_pango":{"value":"B.1.617"},"clade_membership":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"placement_prior":{"value":-4.266930103302002}},"branch_attrs":{"mutations":{"nuc":["G21987A","C25469T"],"ORF3a":["S26L"],"S":["G142D"]},"labels":{"aa":"ORF3a: S26L; S: G142D","spike_mutations":"G142D"}},"children":[{"name":"B.1.617.1","node_attrs":{"div":25,"clade_display":{"value":"21B (Kappa)"},"Nextclade_pango":{"value":"B.1.617.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21B"},"clade_who":{"value":"Kappa"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"21B"},"placement_prior":{"value":-3.281346321105957}},"branch_attrs":{"mutations":{"nuc":["C3457T","C4965T","A11201G","G17523T","A20396G","T21895C","G22022A","G23012C","C26681T","T26767G"],"M":["I82S"],"ORF1a":["T1567I","T3646A"],"ORF1b":["M1352I","K2310R"],"S":["R19T","E154K","E484Q"]},"labels":{"aa":"M: I82S; ORF1a: T1567I, T3646A; ORF1b: M1352I, K2310R; S: R19T, E154K, E484Q","clade":"Kappa","spike_mutations":"R19T, E154K, E484Q"}}},{"name":"NODE_0000521","node_attrs":{"div":19,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.944439172744751}},"branch_attrs":{"mutations":{"nuc":["C21618G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22995A","G24410A","T26767C","C27752T","A28271-","A28461G"],"M":["I82T"],"N":["D63G"],"ORF7a":["T120I"],"ORF9b":["T60A"],"S":["E156-","F157-","R158G","T478K","D950N"]},"labels":{"aa":"M: I82T; N: D63G; ORF7a: T120I; ORF9b: T60A; S: E156-, F157-, R158G, T478K, D950N","clade":"Delta","spike_mutations":"E156-, F157-, R158G, T478K, D950N"}},"children":[{"name":"NODE_0000522","node_attrs":{"div":29,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.1252341270446777}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","C5184T","G9203A","T9678C","C11005A","A17496G","A20396G","A21792C","C28253T"],"ORF1a":["P309L","P1640L","D2980N","F3138S","H3580Q"],"ORF1b":["K2310R"],"S":["K77T"]},"labels":{"aa":"ORF1a: P309L, P1640L, D2980N, F3138S, H3580Q; ORF1b: K2310R; S: K77T","spike_mutations":"K77T"}},"children":[{"name":"AY.35","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.35"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.42242431640625}},"branch_attrs":{"mutations":{"nuc":["A1C","C6027A","C13989T","C16915T","G23012C"],"ORF1a":["P1921Q"],"S":["E484Q"]},"labels":{"aa":"ORF1a: P1921Q; S: E484Q","spike_mutations":"E484Q"}}},{"name":"AY.48","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.48"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A10399G","C10868T","G27948T"],"ORF8":["E19*"]},"labels":{"aa":"ORF8: E19*"}}}]},{"name":"NODE_0000523","node_attrs":{"div":21,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.307433843612671}},"branch_attrs":{"mutations":{"nuc":["G15451A","C16466T"],"ORF1b":["G662S","P1000L"]},"labels":{"aa":"ORF1b: G662S, P1000L"}},"children":[{"name":"B.1.617.2","node_attrs":{"div":21,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-21"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.307433843612671}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000524","node_attrs":{"div":24,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.925917625427246}},"branch_attrs":{"mutations":{"nuc":["C5184T","C9891T","T11418C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-"],"ORF1a":["P1640L","A3209V","V3718A"],"ORF8":["D119-","F120-"]},"labels":{"aa":"ORF1a: P1640L, A3209V, V3718A; ORF8: D119-, F120-"}},"children":[{"name":"NODE_0000525","node_attrs":{"div":29,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.995262622833252}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","T12946C","A20262G","C27739T"],"ORF1a":["P309L"],"ORF7a":["L116F"]},"labels":{"aa":"ORF1a: P309L; ORF7a: L116F"}},"children":[{"name":"NODE_0000526","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.093592643737793}},"branch_attrs":{"mutations":{"nuc":["C6539T","C20320T","C24745T","G28690T","G29427A"],"N":["L139F","R385K"],"ORF1a":["H2092Y"],"ORF1b":["H2285Y"]},"labels":{"aa":"N: L139F, R385K; ORF1a: H2092Y; ORF1b: H2285Y"}},"children":[{"name":"AY.30","node_attrs":{"div":37,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.30"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-02"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.6562891006469727}},"branch_attrs":{"mutations":{"nuc":["C9319T","A13482G","-28271A","G29781T"]}}},{"name":"AY.40","node_attrs":{"div":41,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.40"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["A1558G","C1912T","G2755T","A15892G","G23282T","C28099T","T28297C"],"ORF1a":["I431M"],"ORF1b":["M809V"],"ORF8":["S69L"],"ORF9b":["I5T"],"S":["D574Y"]},"labels":{"aa":"ORF1a: I431M; ORF1b: M809V; ORF8: S69L; ORF9b: I5T; S: D574Y","spike_mutations":"D574Y"}}}]},{"name":"NODE_0000527","node_attrs":{"div":30,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.395604133605957}},"branch_attrs":{"mutations":{"nuc":["C18176T"],"ORF1b":["P1570L"]},"labels":{"aa":"ORF1b: P1570L"}},"children":[{"name":"AY.49","node_attrs":{"div":36,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"21A"},"qc.frameShifts.frameShifts":{"value":"ORF3a:30-276"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF3a:30-276"},"partiallyAliased":{"value":"B.1.617.2.49"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T5773C","C10834T","C23039G","G24124T","G25471-","A25472-","T25473-","T25474-","T25475-","T25476-","G25477-","T25478-","C26110T","A27979T"],"ORF3a":["L26-","D27-","F28-","V29-"],"ORF8":["Q29L"],"S":["Q493E","K854N"]},"labels":{"aa":"ORF3a: L26-, D27-, F28-, V29-; ORF8: Q29L; S: Q493E, K854N","spike_mutations":"Q493E, K854N"}}},{"name":"AY.50","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.50"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C884T","C5730T","C19554T","G22484C","-28271A","G28809T"],"N":["G179V"],"ORF1a":["R207C","T1822I"],"S":["V308L"]},"labels":{"aa":"N: G179V; ORF1a: R207C, T1822I; S: V308L","spike_mutations":"V308L"}}},{"name":"AY.52","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.52"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["T24984G","T25689C","G26428T","C26858T","C28419T"],"E":["V62F"],"N":["T49I"],"S":["L1141W"]},"labels":{"aa":"E: V62F; N: T49I; S: L1141W","spike_mutations":"L1141W"}}},{"name":"AY.53","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.53"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.5879409313201904}},"branch_attrs":{"mutations":{"nuc":["G1738T","A2292C","C18348T","C20031T","G21641T"],"ORF1a":["Q676P"],"S":["A27S"]},"labels":{"aa":"ORF1a: Q676P; S: A27S","spike_mutations":"A27S"}}},{"name":"AY.8","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.8"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.8487331867218018}},"branch_attrs":{"mutations":{"nuc":["C11455T","A14170G"],"ORF1b":["I235V"]},"labels":{"aa":"ORF1b: I235V"}}},{"name":"NODE_0000528","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.849754571914673}},"branch_attrs":{"mutations":{"nuc":["A18468G"]}},"children":[{"name":"AY.13","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.13"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.3170342445373535}},"branch_attrs":{"mutations":{"nuc":["A17406G","C29095T"]}}},{"name":"NODE_0000529","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{"nuc":["T26076A"]}},"children":[{"name":"AY.16","node_attrs":{"div":32,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.16"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{}}},{"name":"AY.16.1","node_attrs":{"div":37,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.16.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C8407T","A12417G","G12911A","C14913T","T29867A"],"ORF1a":["N4051S","V4216I"]},"labels":{"aa":"ORF1a: N4051S, V4216I"}}}]}]},{"name":"NODE_0000530","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.429879188537598}},"branch_attrs":{"mutations":{"nuc":["C19160T"],"ORF1b":["S1898F"]},"labels":{"aa":"ORF1b: S1898F"}},"children":[{"name":"AY.15","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.15"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.385550022125244}},"branch_attrs":{"mutations":{"nuc":["A16872G","G27382C","-28271A"],"ORF6":["D61H"]},"labels":{"aa":"ORF6: D61H"}}},{"name":"AY.14","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.14"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.01540470123291}},"branch_attrs":{"mutations":{"nuc":["T1877G","G20718T"],"ORF1a":["S538A"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1a: S538A; ORF1b: M2417I"}}},{"name":"AY.54","node_attrs":{"div":35,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.54"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-3.0774948596954346}},"branch_attrs":{"mutations":{"nuc":["A1G","C193T","G14187A","A25806G"]}}}]},{"name":"NODE_0000531","node_attrs":{"div":31,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.021132946014404}},"branch_attrs":{"mutations":{"nuc":["A25562G"],"ORF3a":["Q57R"]},"labels":{"aa":"ORF3a: Q57R"}},"children":[{"name":"AY.17","node_attrs":{"div":34,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.17"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2240G","C14708T","C17436T","-28271A"],"ORF1a":["I659V"],"ORF1b":["A414V"]},"labels":{"aa":"ORF1a: I659V; ORF1b: A414V"}}},{"name":"AY.19","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.19"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25019T","G25947T","-28271A"],"ORF3a":["Q185H"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: Q185H; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"AY.51","node_attrs":{"div":33,"clade_display":{"value":"21A (Delta)"},"Nextclade_pango":{"value":"AY.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21A"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.51"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21A"},"placement_prior":{"value":-4.13735818862915}},"branch_attrs":{"mutations":{"nuc":["G12223T","A25697T"],"ORF3a":["E102V"]},"labels":{"aa":"ORF3a: E102V"}}}]}]}]},{"name":"NODE_0000532","node_attrs":{"div":26,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.616595983505249}},"branch_attrs":{"mutations":{"nuc":["C11514T","C22227T"],"ORF1a":["T3750I"],"S":["A222V"]},"labels":{"aa":"ORF1a: T3750I; S: A222V","clade":"21I","spike_mutations":"A222V"}},"children":[{"name":"AY.62","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.62"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["A1045T","G1820A","A20085G","C28093T","G29440A"],"ORF1a":["G519S"],"ORF8":["S67F"]},"labels":{"aa":"ORF1a: G519S; ORF8: S67F"}}},{"name":"NODE_0000533","node_attrs":{"div":27,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.667755365371704}},"branch_attrs":{"mutations":{"nuc":["A5584G"]}},"children":[{"name":"AY.24","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.24"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-17"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.5928659439086914}},"branch_attrs":{"mutations":{"nuc":["C23896T","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"NODE_0000534","node_attrs":{"div":28,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.900347948074341}},"branch_attrs":{"mutations":{"nuc":["C13019T"]}},"children":[{"name":"AY.10","node_attrs":{"div":34,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.10"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.07296895980835}},"branch_attrs":{"mutations":{"nuc":["G219T","A8651G","G9526T","C12756T","C13665T","A23734G"],"ORF1a":["M2796V","M3087I","T4164I"]},"labels":{"aa":"ORF1a: M2796V, M3087I, T4164I"}}},{"name":"AY.11","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.11"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-09"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.418825149536133}},"branch_attrs":{"mutations":{"nuc":["C3486T","C18526T","T19516C","G26526T","C29509T"],"M":["A2S"],"ORF1a":["A1074V"],"ORF1b":["R1687C"]},"labels":{"aa":"M: A2S; ORF1a: A1074V; ORF1b: R1687C"}}},{"name":"AY.27","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.27"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.842771530151367}},"branch_attrs":{"mutations":{"nuc":["T11938C","A14475G","G29422T"]}}},{"name":"AY.28","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.28"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C335T","G2167T","C8950T","C9246T","G23663T","G24794T","G25855T"],"ORF1a":["R24C","K634N","A2994V"],"ORF3a":["D155Y"],"S":["A701S","A1078S"]},"labels":{"aa":"ORF1a: R24C, K634N, A2994V; ORF3a: D155Y; S: A701S, A1078S","spike_mutations":"A701S, A1078S"}}},{"name":"AY.47","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.47"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.620307207107544}},"branch_attrs":{"mutations":{"nuc":["C1684T","G5164T","C12049T","G22427A","G28326T"],"N":["G18V"],"ORF1a":["E1633D"],"ORF9b":["V15L"],"S":["V289I"]},"labels":{"aa":"N: G18V; ORF1a: E1633D; ORF9b: V15L; S: V289I","spike_mutations":"V289I"}}},{"name":"AY.55","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.55"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.71439266204834}},"branch_attrs":{"mutations":{"nuc":["A10978G","-28271A"]}}},{"name":"AY.56","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.56"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3634T","C25624T","G27870T"],"ORF3a":["H78Y"],"ORF7b":["E39*"]},"labels":{"aa":"ORF3a: H78Y; ORF7b: E39*"}}},{"name":"AY.57","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.57"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.764986515045166}},"branch_attrs":{"mutations":{"nuc":["C1403T","G5584T"],"ORF1a":["P380S"]},"labels":{"aa":"ORF1a: P380S"}}},{"name":"AY.59","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.59"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C19164T","T20391G","C21302T"],"ORF1b":["P2612L"]},"labels":{"aa":"ORF1b: P2612L"}}},{"name":"AY.60","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.60"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A2165C","C2919T","G4162T","T8634C","T12056A","T13701C","G17122T"],"ORF1a":["K634Q","P885L","I2790T","C3931S"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1a: K634Q, P885L, I2790T, C3931S; ORF1b: A1219S"}}},{"name":"AY.61","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.61"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9422552585601807}},"branch_attrs":{"mutations":{"nuc":["T25532C"],"ORF3a":["I47T"]},"labels":{"aa":"ORF3a: I47T"}}},{"name":"AY.64","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.64"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9437766075134277}},"branch_attrs":{"mutations":{"nuc":["T2C","C346T","C5784T","C6388T","C24130T","G25135T","G25691T","C27005T","G29254T","G29688T"],"ORF1a":["T1840I"],"ORF3a":["G100V"],"S":["K1191N"]},"labels":{"aa":"ORF1a: T1840I; ORF3a: G100V; S: K1191N","spike_mutations":"K1191N"}}},{"name":"AY.67","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.67"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C4890T","T5644C","T19519C","A27368G"],"ORF1a":["T1542I"],"ORF1b":["Y2018H"],"ORF6":["Q56R"]},"labels":{"aa":"ORF1a: T1542I; ORF1b: Y2018H; ORF6: Q56R"}}},{"name":"AY.68","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.68"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.760132312774658}},"branch_attrs":{"mutations":{"nuc":["G105T","C3294T","C8208T","C14362T","C19524T","A22320C","T24499A","C25782T","A26891G","T27878C"],"ORF1a":["P1010L","T2648I"],"S":["D253A","D979E"]},"labels":{"aa":"ORF1a: P1010L, T2648I; S: D253A, D979E","spike_mutations":"D253A, D979E"}}},{"name":"AY.66","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.66"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T13C","T6496C","G14874T","C28892T"],"N":["P207S"],"ORF1b":["K469N"]},"labels":{"aa":"N: P207S; ORF1b: K469N"}}},{"name":"AY.69","node_attrs":{"div":36,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.69"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C3984T","A4405T","A4838G","G9431A","G16864A","G17847A","G25720T","C27559T"],"ORF1a":["T1240I","I1525V","V3056I"],"ORF1b":["V1133I"],"ORF3a":["A110S"]},"labels":{"aa":"ORF1a: T1240I, I1525V, V3056I; ORF1b: V1133I; ORF3a: A110S"}}},{"name":"AY.70","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.70"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.4444899559020996}},"branch_attrs":{"mutations":{"nuc":["C4891T","G21255T","G21624C","G28899T","G28903T"],"N":["R209I","M210I"],"S":["R21T"]},"labels":{"aa":"N: R209I, M210I; S: R21T","spike_mutations":"R21T"}}},{"name":"NODE_0000535","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.80359411239624}},"branch_attrs":{"mutations":{"nuc":["C5192T"]}},"children":[{"name":"AY.58","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.58"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["G8540A","C26079A","C27131T"],"ORF1a":["A2759T"]},"labels":{"aa":"ORF1a: A2759T"}}},{"name":"AY.63","node_attrs":{"div":39,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.63"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.740610122680664}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","A7886G","C8964T","C9857T","C13335T","A14246G","A19126G","A23848G","C25710T","G29616T","T29728C"],"ORF1a":["K141-","S142-","F143-","I2541V","S2900L","A4357V"],"ORF1b":["D260G","I1887V"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, I2541V, S2900L, A4357V; ORF1b: D260G, I1887V"}}}]},{"name":"NODE_0000536","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1813859939575195}},"branch_attrs":{"mutations":{"nuc":["C21622T"]}},"children":[{"name":"AY.75","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1813859939575195}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000537","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.644587278366089}},"branch_attrs":{"mutations":{"nuc":["G29744A"]}},"children":[{"name":"AY.75.2","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-19"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T13C","T7717C","A16824G","A21987G","G23611T"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}}},{"name":"AY.75.3","node_attrs":{"div":36,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.75.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.75.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-19"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T322C","C1329A","G8428A","G16873A","T19127C","C22314T"],"ORF1a":["T355N"],"ORF1b":["G1136S","I1887T"],"S":["P251L"]},"labels":{"aa":"ORF1a: T355N; ORF1b: G1136S, I1887T; S: P251L","spike_mutations":"P251L"}}}]}]},{"name":"NODE_0000538","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.335732936859131}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"AY.9","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.335732936859131}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000539","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.805464744567871}},"branch_attrs":{"mutations":{"nuc":["G1729A","G14030A","C18086T"],"ORF1b":["R188Q","T1540I"]},"labels":{"aa":"ORF1b: R188Q, T1540I"}},"children":[{"name":"AY.9.2","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.805464744567871}},"branch_attrs":{"mutations":{}}},{"name":"AY.9.2.2","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.9.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.9.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6840121746063232}},"branch_attrs":{"mutations":{"nuc":["C4321T","A9685G","C23585A"],"ORF1a":["I3140M"],"S":["Q675K"]},"labels":{"aa":"ORF1a: I3140M; S: Q675K","spike_mutations":"Q675K"}}}]}]},{"name":"NODE_0000540","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-2.977773427963257}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.133","node_attrs":{"div":40,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.133"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.133"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-01"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["C203T","C449T","C4763T","C12025T","C20104T","T21613A","C21614T","C23058G","C24370T","T25333C","T29867A"],"ORF1a":["P62S","H1500Y"],"ORF1b":["L2213F"],"S":["N17K","L18F","P499R"]},"labels":{"aa":"ORF1a: P62S, H1500Y; ORF1b: L2213F; S: N17K, L18F, P499R","spike_mutations":"N17K, L18F, P499R"}}},{"name":"NODE_0000541","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T13019C"]}},"children":[{"name":"AY.65","node_attrs":{"div":32,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:121-122"},"partiallyAliased":{"value":"B.1.617.2.65"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G14028T","C27005T","-28253T","-28271A"],"ORF1b":["M187I"]},"labels":{"aa":"ORF1b: M187I"}}},{"name":"NODE_0000542","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.0165014266967773}},"branch_attrs":{"mutations":{"nuc":["A27345T"],"ORF6":["K48N"]},"labels":{"aa":"ORF6: K48N"}},"children":[{"name":"AY.26","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.26"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-25"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.0165014266967773}},"branch_attrs":{"mutations":{}}},{"name":"AY.26.1","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.26.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G20580T","A21987G","G23012C","A24587T","G26529C","G27703T","C29769T"],"M":["D3H"],"ORF7a":["V104F"],"S":["D142G","E484Q","T1009S"]},"labels":{"aa":"M: D3H; ORF7a: V104F; S: D142G, E484Q, T1009S","spike_mutations":"D142G, E484Q, T1009S"}}}]}]}]},{"name":"NODE_0000543","node_attrs":{"div":29,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.119155406951904}},"branch_attrs":{"mutations":{"nuc":["C2509T"]}},"children":[{"name":"AY.2","node_attrs":{"div":38,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-14"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6743454933166504}},"branch_attrs":{"mutations":{"nuc":["A1G","T3055C","G3701A","C17336T","C18570T","G21770T","G22813T","T29867A","G29868A"],"ORF1a":["A1146T"],"ORF1b":["T1290I"],"S":["V70F","K417N"]},"labels":{"aa":"ORF1a: A1146T; ORF1b: T1290I; S: V70F, K417N","spike_mutations":"V70F, K417N"}}},{"name":"AY.38","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.38"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.963697910308838}},"branch_attrs":{"mutations":{"nuc":["G15760T","A22310T","-28271A","G29212T","T29742G"],"ORF1b":["G765C"],"S":["T250S"]},"labels":{"aa":"ORF1b: G765C; S: T250S","spike_mutations":"T250S"}}},{"name":"AY.37","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.37"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.6478559970855713}},"branch_attrs":{"mutations":{"nuc":["G2185T","T20911C"],"ORF1a":["E640D"]},"labels":{"aa":"ORF1a: E640D"}}},{"name":"AY.71","node_attrs":{"div":31,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.71"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.8321352005004883}},"branch_attrs":{"mutations":{"nuc":["A1T","C25317T","-28271A"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"NODE_0000544","node_attrs":{"div":30,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.954825401306152}},"branch_attrs":{"mutations":{"nuc":["G5539A"]}},"children":[{"name":"AY.72","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.72"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-4.11883020401001}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G6080T","A25856G","C26013T"],"ORF1a":["K141-","S142-","F143-","D1939Y"],"ORF3a":["D155G"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, D1939Y; ORF3a: D155G"}}},{"name":"AY.74","node_attrs":{"div":33,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.74"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.1409428119659424}},"branch_attrs":{"mutations":{"nuc":["G3994A","C25413T","G29392T"],"N":["K373N"]},"labels":{"aa":"N: K373N"}}},{"name":"AY.73","node_attrs":{"div":35,"clade_display":{"value":"21I (Delta)"},"Nextclade_pango":{"value":"AY.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21I"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.73"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-22"},"totalAminoacidSubstitutions":{"value":27},"clade_nextstrain":{"value":"21I"},"placement_prior":{"value":-3.9488861560821533}},"branch_attrs":{"mutations":{"nuc":["C222T","C6573T","C27657T","C28409T","C28893T"],"N":["P46S","P207L"],"ORF1a":["S2103F"]},"labels":{"aa":"N: P46S, P207L; ORF1a: S2103F"}}}]}]}]}]}]}]},{"name":"NODE_0000545","node_attrs":{"div":31,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1954586505889893}},"branch_attrs":{"mutations":{"nuc":["G4181T","C6402T","C7124T","C8986T","C10029T","A11201G","A11332G","C19220T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","G28916T"],"N":["G215C"],"ORF1a":["A1306S","P2046L","P2287S","T3255I","T3646A"],"ORF1b":["A1918V"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"]},"labels":{"aa":"N: G215C; ORF1a: A1306S, P2046L, P2287S, T3255I, T3646A; ORF1b: A1918V; ORF7b: T40I; ORF8: D119-, F120-","clade":"21J"}},"children":[{"name":"AY.78","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.78"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.552375793457031}},"branch_attrs":{"mutations":{"nuc":["T13188C","G14874T","G15372T","C21846T","-28271A","C29200T","G29227A"],"ORF1a":["I4308T"],"ORF1b":["K469N"],"S":["T95I"]},"labels":{"aa":"ORF1a: I4308T; ORF1b: K469N; S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000546","node_attrs":{"div":32,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.353039264678955}},"branch_attrs":{"mutations":{"nuc":["G9053T"],"ORF1a":["V2930L"]},"labels":{"aa":"ORF1a: V2930L"}},"children":[{"name":"AY.109","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.109"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.109"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6555240154266357}},"branch_attrs":{"mutations":{"nuc":["A11595G","A14836G","C27549T"],"ORF1a":["Q3777R"],"ORF1b":["I457V"]},"labels":{"aa":"ORF1a: Q3777R; ORF1b: I457V"}}},{"name":"AY.44","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.44"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.8053845167160034}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14014G","A29700G"],"ORF1b":["F183V"]},"labels":{"aa":"ORF1b: F183V"}}},{"name":"AY.6","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.7393529415130615}},"branch_attrs":{"mutations":{"nuc":["G2336A","G17331T"],"ORF1a":["D691N"],"ORF1b":["E1288D"]},"labels":{"aa":"ORF1a: D691N; ORF1b: E1288D"}}},{"name":"AY.76","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.76"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.615240097045898}},"branch_attrs":{"mutations":{"nuc":["T7233C","A16775G"],"ORF1a":["L2323S"],"ORF1b":["Y1103C"]},"labels":{"aa":"ORF1a: L2323S; ORF1b: Y1103C"}}},{"name":"AY.77","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:120-122"},"partiallyAliased":{"value":"B.1.617.2.77"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.287630558013916}},"branch_attrs":{"mutations":{"nuc":["C10376T","T27346C","-28250T","-28251T","-28252T","-28253C"],"ORF1a":["P3371S"],"ORF6":["Y49H"]},"labels":{"aa":"ORF1a: P3371S; ORF6: Y49H"}}},{"name":"AY.79","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.79"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7262611389160156}},"branch_attrs":{"mutations":{"nuc":["T2125C"]}}},{"name":"AY.80","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.80"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.398505210876465}},"branch_attrs":{"mutations":{"nuc":["G5017A","G12479A","C19186T","G19735T","G28028T"],"ORF1a":["V4072I"],"ORF1b":["D2090Y"],"ORF8":["W45C"]},"labels":{"aa":"ORF1a: V4072I; ORF1b: D2090Y; ORF8: W45C"}}},{"name":"AY.81","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.81"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.495386123657227}},"branch_attrs":{"mutations":{"nuc":["G11358A","C23643T","G25340T","A28032G","C28087T","C29530T"],"ORF1a":["R3698K"],"ORF8":["I47V","A65V"],"S":["A694V","D1260Y"]},"labels":{"aa":"ORF1a: R3698K; ORF8: I47V, A65V; S: A694V, D1260Y","spike_mutations":"A694V, D1260Y"}}},{"name":"AY.82","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.82"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.4367475509643555}},"branch_attrs":{"mutations":{"nuc":["C9144T","C22783T"],"ORF1a":["S2960F"]},"labels":{"aa":"ORF1a: S2960F"}}},{"name":"AY.83","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.83"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.207631587982178}},"branch_attrs":{"mutations":{"nuc":["C5544T","G15243T","A25491T"],"ORF1a":["T1760I"],"ORF1b":["M592I"]},"labels":{"aa":"ORF1a: T1760I; ORF1b: M592I"}}},{"name":"AY.84","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.84"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.84"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.880310297012329}},"branch_attrs":{"mutations":{"nuc":["C27297T","G28086T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"AY.86","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.86"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.149416446685791}},"branch_attrs":{"mutations":{"nuc":["G15380T","G24095T","C29445T"],"N":["T391I"],"ORF1b":["S638I"],"S":["A845S"]},"labels":{"aa":"N: T391I; ORF1b: S638I; S: A845S","spike_mutations":"A845S"}}},{"name":"AY.87","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.87"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.119330883026123}},"branch_attrs":{"mutations":{"nuc":["C832T","C2091T","C12651T","C17156T","A19815T","G27556T"],"ORF1a":["T609I","T4129I"],"ORF1b":["T1230I"],"ORF7a":["A55S"]},"labels":{"aa":"ORF1a: T609I, T4129I; ORF1b: T1230I; ORF7a: A55S"}}},{"name":"AY.88","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.88"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.88"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.2233734130859375}},"branch_attrs":{"mutations":{"nuc":["G20709T","C28724T"],"N":["P151S"],"ORF1b":["M2414I"]},"labels":{"aa":"N: P151S; ORF1b: M2414I"}}},{"name":"AY.93","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.93"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.93"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.618436336517334}},"branch_attrs":{"mutations":{"nuc":["A1087G","C1101T","C7262T"],"ORF1a":["S279F","L2333F"]},"labels":{"aa":"ORF1a: S279F, L2333F"}}},{"name":"AY.94","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.94"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.94"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7355687618255615}},"branch_attrs":{"mutations":{"nuc":["G463A","G6367T","C15924T","G16975T","C22987T"],"ORF1a":["Q2034H"],"ORF1b":["V1170F"]},"labels":{"aa":"ORF1a: Q2034H; ORF1b: V1170F"}}},{"name":"NODE_0000547","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.328933000564575}},"branch_attrs":{"mutations":{"nuc":["A17236G"],"ORF1b":["I1257V"]},"labels":{"aa":"ORF1b: I1257V"}},"children":[{"name":"AY.103","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.103"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.103"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7267297506332397}},"branch_attrs":{"mutations":{"nuc":["C24208T"]}}},{"name":"AY.41","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.41"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3743410110473633}},"branch_attrs":{"mutations":{"nuc":["G1820A","G2272T","G7936T","G9220A","A13712G","C14119T","C18395T","G22346T","G22992T","G25062T","-28271A"],"ORF1a":["G519S","K669N"],"ORF1b":["K82R","P218S","A1643V"],"S":["A262S","S477I","G1167V"]},"labels":{"aa":"ORF1a: G519S, K669N; ORF1b: K82R, P218S, A1643V; S: A262S, S477I, G1167V","spike_mutations":"A262S, S477I, G1167V"}}}]},{"name":"NODE_0000548","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.456480503082275}},"branch_attrs":{"mutations":{"nuc":["C897T","C5730T","A7519C","C15738T","G17790T","C25350T","G27762T"],"ORF1a":["A211V","T1822I"],"ORF1b":["Q1441H"],"ORF7b":["E3*"],"S":["P1263L"]},"labels":{"aa":"ORF1a: A211V, T1822I; ORF1b: Q1441H; ORF7b: E3*; S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"AY.123","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.123"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-23"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.456480503082275}},"branch_attrs":{"mutations":{}}},{"name":"AY.123.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.123.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.123.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.658047676086426}},"branch_attrs":{"mutations":{"nuc":["G20002T","A24410G"],"ORF1b":["D2179Y"],"S":["N950D"]},"labels":{"aa":"ORF1b: D2179Y; S: N950D","spike_mutations":"N950D"}}}]},{"name":"NODE_0000549","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.341156005859375}},"branch_attrs":{"mutations":{"nuc":["C1404T","C4752T","G25352T"],"ORF1a":["P380L","T1496I"],"S":["V1264L"]},"labels":{"aa":"ORF1a: P380L, T1496I; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.23","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.23"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.341156005859375}},"branch_attrs":{"mutations":{}}},{"name":"AY.23.1","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.23.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4683516025543213}},"branch_attrs":{"mutations":{"nuc":["C1263T","C5497T","A7537G","C12100T","A14748G","G17679T","T22213C","C25262A"],"ORF1a":["T333M"],"S":["L1234I"]},"labels":{"aa":"ORF1a: T333M; S: L1234I","spike_mutations":"L1234I"}}}]},{"name":"NODE_0000550","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.604698181152344}},"branch_attrs":{"mutations":{"nuc":["C23277T","G24124A","-28271A"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"AY.32","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.32"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-03"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.967384099960327}},"branch_attrs":{"mutations":{"nuc":["C9286T","C21304T"],"ORF1b":["R2613C"]},"labels":{"aa":"ORF1b: R2613C"}}},{"name":"AY.95","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.95"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.95"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.071098804473877}},"branch_attrs":{"mutations":{"nuc":["T22293C"],"S":["L244S"]},"labels":{"aa":"S: L244S","spike_mutations":"L244S"}}}]},{"name":"NODE_0000551","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.153012275695801}},"branch_attrs":{"mutations":{"nuc":["A21647G","C22311T"],"S":["T29A","T250I"]},"labels":{"aa":"S: T29A, T250I","spike_mutations":"T29A, T250I"}},"children":[{"name":"AY.33.1","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:77-122"},"partiallyAliased":{"value":"B.1.617.2.33.1"},"totalAminoacidDeletions":{"value":26},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C4182T","T10190C","A11111G","C14318T","C17439T","A18887G","G21010T","C21707T","C22458T","G23401T","G23522A","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-"],"ORF1a":["S1306F","S3309P","M3616V"],"ORF1b":["T284I","H1807R","V2515L"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-"],"S":["H49Y","T299I","Q613H","E654K"]},"labels":{"aa":"ORF1a: S1306F, S3309P, M3616V; ORF1b: T284I, H1807R, V2515L; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-; S: H49Y, T299I, Q613H, E654K","spike_mutations":"H49Y, T299I, Q613H, E654K"}}},{"name":"AY.33","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.33"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.153012275695801}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000552","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.514620304107666}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"AY.46.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.053738117218018}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T","G14186T","C19637T","A21987G","G28378T"],"ORF1a":["A3571V"],"ORF1b":["R240M","A2057V"],"ORF9b":["R32L"],"S":["D142G"]},"labels":{"aa":"ORF1a: A3571V; ORF1b: R240M, A2057V; ORF9b: R32L; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.90","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.90"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.90"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9251A","C25931T","G26720A","G27990T","T28735C"],"ORF1a":["V2996I"],"ORF3a":["S180F"],"ORF8":["V33F"]},"labels":{"aa":"ORF1a: V2996I; ORF3a: S180F; ORF8: V33F"}}}]},{"name":"NODE_0000553","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.887284278869629}},"branch_attrs":{"mutations":{"nuc":["G526T","C19524T"],"ORF1a":["E87D"]},"labels":{"aa":"ORF1a: E87D"}},"children":[{"name":"AY.98","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.98"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.887284278869629}},"branch_attrs":{"mutations":{}}},{"name":"AY.98.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.98.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.98.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.6238064765930176}},"branch_attrs":{"mutations":{"nuc":["G2518T","G5437T","C7768T","C22314T","G28086T"],"ORF1a":["E1724D"],"ORF8":["A65S"],"S":["P251L"]},"labels":{"aa":"ORF1a: E1724D; ORF8: A65S; S: P251L","spike_mutations":"P251L"}}}]},{"name":"NODE_0000554","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.317579746246338}},"branch_attrs":{"mutations":{"nuc":["A1G","G26107C","A27507C"],"ORF3a":["E239Q"]},"labels":{"aa":"ORF3a: E239Q"}},"children":[{"name":"AY.25","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.317579746246338}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000555","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432563543319702}},"branch_attrs":{"mutations":{"nuc":["A3948G","G11562T"],"ORF1a":["D1228G","C3766F"]},"labels":{"aa":"ORF1a: D1228G, C3766F"}},"children":[{"name":"AY.25.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432563543319702}},"branch_attrs":{"mutations":{}}},{"name":"AY.25.1.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.25.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.25.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2407732009887695}},"branch_attrs":{"mutations":{"nuc":["G2564A","A21987G","G23948T"],"ORF1a":["E767K"],"S":["D142G","D796Y"]},"labels":{"aa":"ORF1a: E767K; S: D142G, D796Y","spike_mutations":"D142G, D796Y"}}}]}]},{"name":"NODE_0000556","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.293525695800781}},"branch_attrs":{"mutations":{"nuc":["C25413T","-28271A"]}},"children":[{"name":"AY.45","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.45"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.303795337677002}},"branch_attrs":{"mutations":{"nuc":["G13812T"],"ORF1b":["M115I"]},"labels":{"aa":"ORF1b: M115I"}}},{"name":"NODE_0000557","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.198975563049316}},"branch_attrs":{"mutations":{"nuc":["T1871C","C28236T","G29744A"],"ORF1a":["F536L"],"ORF8":["R115C"]},"labels":{"aa":"ORF1a: F536L; ORF8: R115C"}},"children":[{"name":"AY.91.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.91.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.92111349105835}},"branch_attrs":{"mutations":{"nuc":["C15540T","C17010T","G25650T","A28271-","C28310T"],"N":["P13S"],"ORF3a":["L86F"]},"labels":{"aa":"N: P13S; ORF3a: L86F"}}},{"name":"AY.91","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.91"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.91"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.198975563049316}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000558","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.897754669189453}},"branch_attrs":{"mutations":{"nuc":["T2C","G2944A","G11365T","G12718T","G27566T","C27629A"],"ORF1a":["Q4151H"],"ORF7a":["C58F","A79D"]},"labels":{"aa":"ORF1a: Q4151H; ORF7a: C58F, A79D"}},"children":[{"name":"AY.7","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.897754669189453}},"branch_attrs":{"mutations":{}}},{"name":"AY.7.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-13"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1598992347717285}},"branch_attrs":{"mutations":{"nuc":["T15882G","A18675G"]}}},{"name":"AY.7.2","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.7.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-13"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.763446092605591}},"branch_attrs":{"mutations":{"nuc":["C2T","G25445T"],"ORF3a":["G18V"]},"labels":{"aa":"ORF3a: G18V"}}}]},{"name":"NODE_0000559","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5587968826293945}},"branch_attrs":{"mutations":{"nuc":["A3536G","T13216C","C15240T"],"ORF1a":["I1091V"]},"labels":{"aa":"ORF1a: I1091V"}},"children":[{"name":"AY.99","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5587968826293945}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000560","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.528911113739014}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.99.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.143618583679199}},"branch_attrs":{"mutations":{"nuc":["C8994T"],"ORF1a":["T2910I"]},"labels":{"aa":"ORF1a: T2910I"}}},{"name":"AY.99.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.99.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.99.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.7914319038391113}},"branch_attrs":{"mutations":{"nuc":["C4927T","A5638G","C12525T"],"ORF1a":["T4087I"]},"labels":{"aa":"ORF1a: T4087I"}}}]}]},{"name":"NODE_0000561","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.159926652908325}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"ORF1a":["K261N"]},"labels":{"aa":"ORF1a: K261N"}},"children":[{"name":"AY.122","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.159926652908325}},"branch_attrs":{"mutations":{}}},{"name":"AY.122.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5672764778137207}},"branch_attrs":{"mutations":{"nuc":["C19983T","G20937T","C23934T","C25516T"],"ORF3a":["P42S"],"S":["T791I"]},"labels":{"aa":"ORF3a: P42S; S: T791I","spike_mutations":"T791I"}}},{"name":"AY.122.3","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.337822437286377}},"branch_attrs":{"mutations":{"nuc":["T168C","C12513T","G17338A","T17694C","T20838C","G23401T","C27527T","C28873A"],"ORF1a":["T4083M"],"ORF1b":["A1291T"],"ORF7a":["P45L"],"S":["Q613H"]},"labels":{"aa":"ORF1a: T4083M; ORF1b: A1291T; ORF7a: P45L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"AY.122.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.122.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.122.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7381060123443604}},"branch_attrs":{"mutations":{"nuc":["G13892A","G14772A","G22793T"],"ORF1b":["C142Y"],"S":["A411S"]},"labels":{"aa":"ORF1b: C142Y; S: A411S","spike_mutations":"A411S"}}}]},{"name":"NODE_0000562","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.67804217338562}},"branch_attrs":{"mutations":{"nuc":["T3C","A11456G","G29050A","C29509T"],"ORF1a":["I3731V"]},"labels":{"aa":"ORF1a: I3731V"}},"children":[{"name":"AY.3","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-30"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.67804217338562}},"branch_attrs":{"mutations":{}}},{"name":"AY.3.2","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.84430193901062}},"branch_attrs":{"mutations":{"nuc":["G5155A","C5784T","A10075G","A21987G","C22338T","C29546T","C29750T"],"ORF1a":["T1840I"],"S":["D142G","T259I"]},"labels":{"aa":"ORF1a: T1840I; S: D142G, T259I","spike_mutations":"D142G, T259I"}}},{"name":"NODE_0000563","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.2109897136688232}},"branch_attrs":{"mutations":{"nuc":["T23284C","C25339T"]}},"children":[{"name":"AY.3.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-23"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9937832355499268}},"branch_attrs":{"mutations":{"nuc":["G3644T","C18115T","C20199T","A21987G"],"ORF1a":["D1127Y"],"ORF1b":["H1550Y"],"S":["D142G"]},"labels":{"aa":"ORF1a: D1127Y; ORF1b: H1550Y; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.3.3","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.3.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.715099811553955}},"branch_attrs":{"mutations":{"nuc":["T2083C","A6229G","C9924T","T12538C","G21770A","A22803G","A26021C"],"ORF1a":["A3220V"],"ORF3a":["D210A"],"S":["V70I","Q414R"]},"labels":{"aa":"ORF1a: A3220V; ORF3a: D210A; S: V70I, Q414R","spike_mutations":"V70I, Q414R"}}}]}]},{"name":"NODE_0000564","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3763246536254883}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T"],"ORF1a":["A3571V"]},"labels":{"aa":"ORF1a: A3571V"}},"children":[{"name":"AY.46.2","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9185075759887695}},"branch_attrs":{"mutations":{"nuc":["A17799G","-28271A"]}}},{"name":"AY.46","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3763246536254883}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.46.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.001236915588379}},"branch_attrs":{"mutations":{"nuc":["T25673C"],"ORF3a":["L94P"]},"labels":{"aa":"ORF3a: L94P"}}},{"name":"AY.46.6","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.815885066986084}},"branch_attrs":{"mutations":{"nuc":["C6310T","C8326T"]}}},{"name":"AY.46.5","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0684127807617188}},"branch_attrs":{"mutations":{"nuc":["C15569T","T16242G"],"ORF1b":["T701I"]},"labels":{"aa":"ORF1b: T701I"}}},{"name":"AY.46.4","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.46.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.46.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.352943181991577}},"branch_attrs":{"mutations":{"nuc":["G23545T"],"S":["E661D"]},"labels":{"aa":"S: E661D","spike_mutations":"E661D"}}}]},{"name":"NODE_0000565","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6843671798706055}},"branch_attrs":{"mutations":{"nuc":["G24928T"]}},"children":[{"name":"AY.5","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6843671798706055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000566","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.432929515838623}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}},"children":[{"name":"AY.5.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.634615898132324}},"branch_attrs":{"mutations":{"nuc":["C27143A"],"M":["N207K"]},"labels":{"aa":"M: N207K"}}},{"name":"AY.5.3","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.852130651473999}},"branch_attrs":{"mutations":{"nuc":["C7488T"],"ORF1a":["T2408I"]},"labels":{"aa":"ORF1a: T2408I"}}},{"name":"AY.5.4","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5176773071289062}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"ORF1a":["P309L"]},"labels":{"aa":"ORF1a: P309L"}}},{"name":"AY.5.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.416350364685059}},"branch_attrs":{"mutations":{"nuc":["C12369T","C25572T"],"ORF1a":["T4035I"]},"labels":{"aa":"ORF1a: T4035I"}}},{"name":"AY.5.5","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.5.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C6840T","G17193T","T23398C"],"ORF1a":["A2192V"],"ORF1b":["E1242D"]},"labels":{"aa":"ORF1a: A2192V; ORF1b: E1242D"}}}]}]},{"name":"NODE_0000567","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.3014614582061768}},"branch_attrs":{"mutations":{"nuc":["C15952A","A28299T"],"N":["Q9L"],"ORF1b":["L829I"],"ORF9b":["S6C"]},"labels":{"aa":"N: Q9L; ORF1b: L829I; ORF9b: S6C"}},"children":[{"name":"AY.43","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.3014614582061768}},"branch_attrs":{"mutations":{}}},{"name":"AY.43.5","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["A17457G","A23064G","C23638T","C24937T","C28045T","G28857T","G29179T"],"N":["R195I"],"ORF8":["A51V"],"S":["N501S"]},"labels":{"aa":"N: R195I; ORF8: A51V; S: N501S","spike_mutations":"N501S"}}},{"name":"NODE_0000568","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.2774245738983154}},"branch_attrs":{"mutations":{"nuc":["C18744T","C24130T"]}},"children":[{"name":"AY.43.3","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.8283350467681885}},"branch_attrs":{"mutations":{"nuc":["C19955T"],"ORF1b":["T2163I"]},"labels":{"aa":"ORF1b: T2163I"}}},{"name":"AY.43.4","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.776319980621338}},"branch_attrs":{"mutations":{"nuc":["C5241T"],"ORF1a":["P1659L"]},"labels":{"aa":"ORF1a: P1659L"}}},{"name":"AY.43.6","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3442535400390625}},"branch_attrs":{"mutations":{"nuc":["C233T","C1952A","T27409C","G29081T"],"N":["V270L"],"ORF1a":["Q563K"],"ORF7a":["F6L"]},"labels":{"aa":"N: V270L; ORF1a: Q563K; ORF7a: F6L"}}},{"name":"NODE_0000569","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.388669013977051}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.43.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.167776584625244}},"branch_attrs":{"mutations":{"nuc":["C12663T","C25433T"],"ORF1a":["A4133V"],"ORF3a":["T14I"]},"labels":{"aa":"ORF1a: A4133V; ORF3a: T14I"}}},{"name":"AY.43.2","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.031640529632568}},"branch_attrs":{"mutations":{"nuc":["G3728T"],"ORF1a":["G1155C"]},"labels":{"aa":"ORF1a: G1155C"}}},{"name":"AY.43.7","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.43.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.43.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-26"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.195249557495117}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}}}]}]}]},{"name":"NODE_0000570","node_attrs":{"div":33,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.174302339553833}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}},"children":[{"name":"AY.1","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-04"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.566736936569214}},"branch_attrs":{"mutations":{"nuc":["G22335T","G22813T"],"S":["W258L","K417N"]},"labels":{"aa":"S: W258L, K417N","spike_mutations":"W258L, K417N"}}},{"name":"AY.105","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.105"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.105"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.090245246887207}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2939T"],"ORF1a":["P892S"]},"labels":{"aa":"ORF1a: P892S"}}},{"name":"AY.107","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.107"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.107"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.489321231842041}},"branch_attrs":{"mutations":{"nuc":["A15012G","C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"AY.106","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.106"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.106"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.667900800704956}},"branch_attrs":{"mutations":{"nuc":["C9811T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"AY.112","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.112"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.112"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2532191276550293}},"branch_attrs":{"mutations":{"nuc":["G25647T","-28271A"],"ORF3a":["L85F"]},"labels":{"aa":"ORF3a: L85F"}}},{"name":"AY.111","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.111"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.111"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.2215194702148438}},"branch_attrs":{"mutations":{"nuc":["C4456T"]}}},{"name":"AY.110","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.110"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.110"},"totalAminoacidDeletions":{"value":7},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5870707035064697}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","C912A"],"ORF1a":["K141-","S142-","F143-","S216Y"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-, S216Y"}}},{"name":"AY.117","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.117"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.117"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.009160041809082}},"branch_attrs":{"mutations":{"nuc":["A1G","G2202T","G14186T","C15810T","C28708T"],"ORF1a":["W646L"],"ORF1b":["R240M"]},"labels":{"aa":"ORF1a: W646L; ORF1b: R240M"}}},{"name":"AY.118","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.118"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.118"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-04"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.8734261989593506}},"branch_attrs":{"mutations":{"nuc":["A1C","T826C","A27338T"],"ORF6":["E46V"]},"labels":{"aa":"ORF6: E46V"}}},{"name":"AY.126","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.126"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.126"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.6275558471679688}},"branch_attrs":{"mutations":{"nuc":["A1T","C14925T","A21137G","A24110C","A25439C"],"ORF1b":["K2557R"],"ORF3a":["K16T"],"S":["I850L"]},"labels":{"aa":"ORF1b: K2557R; ORF3a: K16T; S: I850L","spike_mutations":"I850L"}}},{"name":"AY.129","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.129"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.129"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1022281646728516}},"branch_attrs":{"mutations":{"nuc":["A21194G","G28001T","T28156C"],"ORF1b":["D2576G"],"ORF8":["I88T"]},"labels":{"aa":"ORF1b: D2576G; ORF8: I88T"}}},{"name":"AY.131","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.131"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.131"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-21"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.790039539337158}},"branch_attrs":{"mutations":{"nuc":["C14407T","G19999T","G22899T","A23064C","T29014C","G29688T"],"ORF1b":["L314F","V2178F"],"S":["G446V","N501T"]},"labels":{"aa":"ORF1b: L314F, V2178F; S: G446V, N501T","spike_mutations":"G446V, N501T"}}},{"name":"AY.132","node_attrs":{"div":48,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.132"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.132"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-28"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.3016180992126465}},"branch_attrs":{"mutations":{"nuc":["G1418A","A2172G","C4754T","C7945T","G11161A","T11488C","G18213A","T19500C","A19908G","C23683T","C25710T","G25855T","C27131T","G27870T","C27881A"],"ORF1a":["A385T","K636R","P1497S"],"ORF1b":["M1582I","I2147M"],"ORF3a":["D155Y"],"ORF7b":["E39*","H42Q"]},"labels":{"aa":"ORF1a: A385T, K636R, P1497S; ORF1b: M1582I, I2147M; ORF3a: D155Y; ORF7b: E39*, H42Q"}}},{"name":"AY.92","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.92"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.92"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5235536098480225}},"branch_attrs":{"mutations":{"nuc":["C28657T","C29167T"]}}},{"name":"NODE_0000571","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9998865127563477}},"branch_attrs":{"mutations":{"nuc":["C745T"]}},"children":[{"name":"AY.104","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.104"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.104"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.191296577453613}},"branch_attrs":{"mutations":{"nuc":["T13048C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"AY.108","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.108"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.108"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.212674140930176}},"branch_attrs":{"mutations":{"nuc":["T2C","G370T","C823T","C6828T"],"ORF1a":["S2188F"]},"labels":{"aa":"ORF1a: S2188F"}}}]},{"name":"NODE_0000572","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9742491245269775}},"branch_attrs":{"mutations":{"nuc":["A10691G"],"ORF1a":["I3476V"]},"labels":{"aa":"ORF1a: I3476V"}},"children":[{"name":"AY.116","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.116"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.9742491245269775}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.116.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.116.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.116.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5009799003601074}},"branch_attrs":{"mutations":{"nuc":["G12071A","C19160T","G20968A"],"ORF1a":["D3936N"],"ORF1b":["S1898F","V2501I"]},"labels":{"aa":"ORF1a: D3936N; ORF1b: S1898F, V2501I"}}}]},{"name":"NODE_0000573","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.260836124420166}},"branch_attrs":{"mutations":{"nuc":["G16914T"]}},"children":[{"name":"AY.114","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.114"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.114"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.435910940170288}},"branch_attrs":{"mutations":{"nuc":["C884T","G19677T"],"ORF1a":["R207C"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1a: R207C; ORF1b: Q2070H"}}},{"name":"AY.85","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.85"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-25"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3503634929656982}},"branch_attrs":{"mutations":{"nuc":["A708G","C1825T","T17748A","C25810T","G26428T","C26873T"],"E":["V62F"],"ORF1a":["E148G"],"ORF3a":["L140F"]},"labels":{"aa":"E: V62F; ORF1a: E148G; ORF3a: L140F"}}}]},{"name":"NODE_0000574","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.015812635421753}},"branch_attrs":{"mutations":{"nuc":["A1C","C13168T","C23557T","G25996T"],"ORF3a":["V202L"]},"labels":{"aa":"ORF3a: V202L"}},"children":[{"name":"AY.121","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.121"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.015812635421753}},"branch_attrs":{"mutations":{}}},{"name":"AY.121.1","node_attrs":{"div":46,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.121.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.121.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-25"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4786581993103027}},"branch_attrs":{"mutations":{"nuc":["T209C","T6949C","C16726T","C19859T","C21648T","C27638T","C27737T","G28396A","G29690T"],"ORF1b":["H1087Y","A2131V"],"ORF7a":["A82V","T115I"],"ORF9b":["G38D"],"S":["T29I"]},"labels":{"aa":"ORF1b: H1087Y, A2131V; ORF7a: A82V, T115I; ORF9b: G38D; S: T29I","spike_mutations":"T29I"}}}]},{"name":"NODE_0000575","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5549795627593994}},"branch_attrs":{"mutations":{"nuc":["C1593T","A10323G","C21301A"],"ORF1a":["S443F","K3353R"],"ORF1b":["P2612T"]},"labels":{"aa":"ORF1a: S443F, K3353R; ORF1b: P2612T"}},"children":[{"name":"AY.124.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.124.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-08"},"totalAminoacidSubstitutions":{"value":35},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.1392822265625}},"branch_attrs":{"mutations":{"nuc":["C4276T","G25445T","G25720T","C26058T","G28628T"],"N":["A119S"],"ORF3a":["G18V","A110S"]},"labels":{"aa":"N: A119S; ORF3a: G18V, A110S"}}},{"name":"AY.124","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.124"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.124"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-23"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5549795627593994}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000576","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.08727502822876}},"branch_attrs":{"mutations":{"nuc":["G15906T"],"ORF1b":["Q813H"]},"labels":{"aa":"ORF1b: Q813H"}},"children":[{"name":"AY.125","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.125"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.125"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.753838300704956}},"branch_attrs":{"mutations":{"nuc":["C745T","C6730T","C13944T","G18905A","G25471T","A26786G"],"ORF1b":["R1813H"],"ORF3a":["D27Y"]},"labels":{"aa":"ORF1b: R1813H; ORF3a: D27Y"}}},{"name":"AY.128","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.128"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.128"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.398505210876465}},"branch_attrs":{"mutations":{"nuc":["C2973T","G16795T","T28150C"],"ORF1a":["A903V"],"ORF1b":["V1110L"],"ORF8":["F86S"]},"labels":{"aa":"ORF1a: A903V; ORF1b: V1110L; ORF8: F86S"}}}]},{"name":"NODE_0000577","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.111449956893921}},"branch_attrs":{"mutations":{"nuc":["A1T","G25538T","C26054A"],"ORF3a":["G49V","T221K"]},"labels":{"aa":"ORF3a: G49V, T221K"}},"children":[{"name":"AY.127","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.127"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.111449956893921}},"branch_attrs":{"mutations":{}}},{"name":"AY.127.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.127.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.127.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.655613422393799}},"branch_attrs":{"mutations":{"nuc":["G242A","T7816C","A19445G","G23608T","C24138A","G28378T"],"ORF1b":["K1993R"],"ORF9b":["R32L"],"S":["T859N"]},"labels":{"aa":"ORF1b: K1993R; ORF9b: R32L; S: T859N","spike_mutations":"T859N"}}}]},{"name":"NODE_0000578","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.579427719116211}},"branch_attrs":{"mutations":{"nuc":["A1G","C5239T","T5514C"],"ORF1a":["V1750A"]},"labels":{"aa":"ORF1a: V1750A"}},"children":[{"name":"AY.29","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.29"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-02"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.579427719116211}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.29.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.29.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.29.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4895212650299072}},"branch_attrs":{"mutations":{"nuc":["G22081T"],"S":["Q173H"]},"labels":{"aa":"S: Q173H","spike_mutations":"Q173H"}}}]},{"name":"NODE_0000579","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0413548946380615}},"branch_attrs":{"mutations":{"nuc":["G2258A","C12073T","C15237T","C25872T"],"ORF1a":["V665I"]},"labels":{"aa":"ORF1a: V665I"}},"children":[{"name":"AY.42.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.42.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7342679500579834}},"branch_attrs":{"mutations":{"nuc":["T4081A","C23718T","C24374T"],"ORF1a":["S1272R"],"S":["T719I","L938F"]},"labels":{"aa":"ORF1a: S1272R; S: T719I, L938F","spike_mutations":"T719I, L938F"}}},{"name":"AY.42","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.42"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-18"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0413548946380615}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000580","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.57420015335083}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}},"children":[{"name":"AY.113","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.113"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.113"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0687098503112793}},"branch_attrs":{"mutations":{"nuc":["A1G","C9165T","A10323G","A12772G"],"ORF1a":["T2967I","K3353R"]},"labels":{"aa":"ORF1a: T2967I, K3353R"}}},{"name":"NODE_0000581","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5571038722991943}},"branch_attrs":{"mutations":{"nuc":["C9559T","T28007C"]}},"children":[{"name":"AY.100","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.100"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.100"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.274301290512085}},"branch_attrs":{"mutations":{"nuc":["G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}}},{"name":"AY.101","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.101"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.101"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.416262626647949}},"branch_attrs":{"mutations":{"nuc":["C925T","C9474T","C25460T"],"ORF1a":["A3070V"],"ORF3a":["A23V"]},"labels":{"aa":"ORF1a: A3070V; ORF3a: A23V"}}}]}]},{"name":"NODE_0000582","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9556076526641846}},"branch_attrs":{"mutations":{"nuc":["C8829T","G19006T"],"ORF1a":["A2855V"],"ORF1b":["A1847S"]},"labels":{"aa":"ORF1a: A2855V; ORF1b: A1847S"}},"children":[{"name":"AY.119","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-04"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9556076526641846}},"branch_attrs":{"mutations":{}}},{"name":"AY.119.1","node_attrs":{"div":44,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":38},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.377321720123291}},"branch_attrs":{"mutations":{"nuc":["C100T","C2973T","G17338T","C22227T","T24063C","G25552T","G26031T","T26621C","G29392T"],"N":["K373N"],"ORF1a":["A903V"],"ORF1b":["A1291S"],"ORF3a":["A54S","Q213H"],"S":["A222V","I834T"]},"labels":{"aa":"N: K373N; ORF1a: A903V; ORF1b: A1291S; ORF3a: A54S, Q213H; S: A222V, I834T","spike_mutations":"A222V, I834T"}}},{"name":"AY.119.2","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.119.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.119.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1326918601989746}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000583","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.408951759338379}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"AY.36","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.36"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-27"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.9737071990966797}},"branch_attrs":{"mutations":{"nuc":["T15628C","G18079T","A20532G","C29738T"],"ORF1b":["C721R","V1538L"]},"labels":{"aa":"ORF1b: C721R, V1538L"}}},{"name":"NODE_0000584","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.006218194961548}},"branch_attrs":{"mutations":{"nuc":["C2061T"],"ORF1a":["A599V"]},"labels":{"aa":"ORF1a: A599V"}},"children":[{"name":"AY.20","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.20"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.006218194961548}},"branch_attrs":{"mutations":{}}},{"name":"AY.20.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.20.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.20.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-17"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6867918968200684}},"branch_attrs":{"mutations":{"nuc":["C8880T","G9190T","C11173T","C24106T","G25481T","C27393T","G29737T"],"ORF1a":["T2872M"],"ORF3a":["R30L"]},"labels":{"aa":"ORF1a: T2872M; ORF3a: R30L"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"B.1.617.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1764931678771973}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"AY.22","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.22"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-16"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.319343566894531}},"branch_attrs":{"mutations":{"nuc":["T12496C","G14209T","A21987G","G22216T","G24872T","G26062T"],"ORF1b":["V248F"],"ORF3a":["G224C"],"S":["D142G","Q218H","V1104L"]},"labels":{"aa":"ORF1b: V248F; ORF3a: G224C; S: D142G, Q218H, V1104L","spike_mutations":"D142G, Q218H, V1104L"}}},{"name":"NODE_0000586","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5547027587890625}},"branch_attrs":{"mutations":{"nuc":["G1495T","A27690T","C29836T"]}},"children":[{"name":"AY.102","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-27"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.5547027587890625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000587","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.114130020141602}},"branch_attrs":{"mutations":{"nuc":["A21987G","T25333C","A29700G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.102.1","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-5.037963390350342}},"branch_attrs":{"mutations":{"nuc":["G25218T"],"S":["G1219V"]},"labels":{"aa":"S: G1219V","spike_mutations":"G1219V"}}},{"name":"AY.102.2","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.102.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.102.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.796270847320557}},"branch_attrs":{"mutations":{"nuc":["C26395A","G29861T","G29862A","T29867-"],"E":["L51I"]},"labels":{"aa":"E: L51I"}}}]}]}]},{"name":"NODE_0000588","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0078787803649902}},"branch_attrs":{"mutations":{"nuc":["C6408T","A25003G"],"ORF1a":["S2048F"]},"labels":{"aa":"ORF1a: S2048F"}},"children":[{"name":"AY.120","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.0078787803649902}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.1","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5417470932006836}},"branch_attrs":{"mutations":{"nuc":["C11095T"]}}},{"name":"NODE_0000589","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.590936183929443}},"branch_attrs":{"mutations":{"nuc":["G174T","C21758T"],"S":["H66Y"]},"labels":{"aa":"S: H66Y","spike_mutations":"H66Y"}},"children":[{"name":"AY.120.2","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.590936183929443}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.2.1","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.120.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.120.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.8597543239593506}},"branch_attrs":{"mutations":{"nuc":["C7105T","C13138T","T27017A"]}}}]}]},{"name":"NODE_0000590","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.438511610031128}},"branch_attrs":{"mutations":{"nuc":["A1G","G9441T","G18255T","C22498T","G23593C","G26109A","C26681T","G27014T"],"ORF1a":["C3059F"],"ORF1b":["M1596I"],"S":["Q677H"]},"labels":{"aa":"ORF1a: C3059F; ORF1b: M1596I; S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"AY.34","node_attrs":{"div":41,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.438511610031128}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.2","node_attrs":{"div":45,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":35},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.642725944519043}},"branch_attrs":{"mutations":{"nuc":["G11417T","A14457G","C21110T","C24138T"],"ORF1a":["V3718F"],"ORF1b":["T2548I"],"S":["T859I"]},"labels":{"aa":"ORF1a: V3718F; ORF1b: T2548I; S: T859I","spike_mutations":"T859I"}}},{"name":"NODE_0000591","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6367361545562744}},"branch_attrs":{"mutations":{"nuc":["C25355T","C28961T"],"N":["L230F"],"S":["L1265F"]},"labels":{"aa":"N: L230F; S: L1265F","spike_mutations":"L1265F"}},"children":[{"name":"AY.34.1.1","node_attrs":{"div":46,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.820716381072998}},"branch_attrs":{"mutations":{"nuc":["C2106T","G8017T","A21987G"],"ORF1a":["T614I"],"S":["D142G"]},"labels":{"aa":"ORF1a: T614I; S: D142G","spike_mutations":"D142G"}}},{"name":"AY.34.1","node_attrs":{"div":43,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.34.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.34.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-02"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6367361545562744}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000592","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.79569411277771}},"branch_attrs":{"mutations":{"nuc":["G21372T","G27604A"],"ORF1b":["Q2635H"],"ORF7a":["V71I"]},"labels":{"aa":"ORF1b: Q2635H; ORF7a: V71I"}},"children":[{"name":"AY.39","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.79569411277771}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.2","node_attrs":{"div":40,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-28"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.7347331047058105}},"branch_attrs":{"mutations":{"nuc":["G2494T","G5716T","C6883T","A21987G","G24781C"],"ORF1a":["E743D","K1817N"],"S":["D142G","K1073N"]},"labels":{"aa":"ORF1a: E743D, K1817N; S: D142G, K1073N","spike_mutations":"D142G, K1073N"}}},{"name":"NODE_0000593","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.059364080429077}},"branch_attrs":{"mutations":{"nuc":["A13482G"]}},"children":[{"name":"AY.39.1.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:78-122"},"partiallyAliased":{"value":"B.1.617.2.39.1.3"},"totalAminoacidDeletions":{"value":11},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-17"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.902846097946167}},"branch_attrs":{"mutations":{"nuc":["G2164T","A21987G","C25046G","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF1a":["E633D"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"S":["D142G","P1162A"]},"labels":{"aa":"ORF1a: E633D; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; S: D142G, P1162A","spike_mutations":"D142G, P1162A"}}},{"name":"AY.39.1.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:78-122"},"partiallyAliased":{"value":"B.1.617.2.39.1.2"},"totalAminoacidDeletions":{"value":11},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.295774221420288}},"branch_attrs":{"mutations":{"nuc":["G1577A","C18555T","C25568T","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF1a":["V438I"],"ORF3a":["A59V"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"]},"labels":{"aa":"ORF1a: V438I; ORF3a: A59V; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-"}}},{"name":"AY.39.1","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.059364080429077}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.1.1","node_attrs":{"div":37,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.39.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.39.1.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-11"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.3977465629577637}},"branch_attrs":{"mutations":{"nuc":["G19563T"],"ORF1b":["L2032F"]},"labels":{"aa":"ORF1b: L2032F"}}}]}]},{"name":"NODE_0000594","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7977098226547241}},"branch_attrs":{"mutations":{"nuc":["C7851T"],"ORF1a":["A2529V"]},"labels":{"aa":"ORF1a: A2529V"}},"children":[{"name":"AY.4","node_attrs":{"div":34,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":30},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.7977098226547241}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.10","node_attrs":{"div":44,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.10"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-22"},"totalAminoacidSubstitutions":{"value":37},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.931220293045044}},"branch_attrs":{"mutations":{"nuc":["C4320T","C5512T","T8604C","C10714T","C12513T","A16602G","G20663A","C23996T","G25757T","T27900C"],"ORF1a":["A1352V","F2780S","T4083M"],"ORF1b":["S2399N"],"ORF3a":["R122I"],"ORF8":["F3L"],"S":["P812S"]},"labels":{"aa":"ORF1a: A1352V, F2780S, T4083M; ORF1b: S2399N; ORF3a: R122I; ORF8: F3L; S: P812S","spike_mutations":"P812S"}}},{"name":"AY.4.4","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.4"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.6386144161224365}},"branch_attrs":{"mutations":{"nuc":["G14209T","C21575T","C22000T","G24348C"],"ORF1b":["V248F"],"S":["L5F","S929T"]},"labels":{"aa":"ORF1b: V248F; S: L5F, S929T","spike_mutations":"L5F, S929T"}}},{"name":"AY.4.3","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-08"},"totalAminoacidSubstitutions":{"value":31},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.5429084300994873}},"branch_attrs":{"mutations":{"nuc":["C21638T"],"S":["P26S"]},"labels":{"aa":"S: P26S","spike_mutations":"P26S"}}},{"name":"AY.4.5","node_attrs":{"div":36,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.5"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-12"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.983483076095581}},"branch_attrs":{"mutations":{"nuc":["A14882C","G25337T"],"ORF1b":["D472A"],"S":["D1259Y"]},"labels":{"aa":"ORF1b: D472A; S: D1259Y","spike_mutations":"D1259Y"}}},{"name":"AY.4.7","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.7"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.372633218765259}},"branch_attrs":{"mutations":{"nuc":["A1T","G14829T","G17193T","G26416T","C28291T"],"E":["V58F"],"ORF1b":["M454I","E1242D"],"ORF9b":["P3L"]},"labels":{"aa":"E: V58F; ORF1b: M454I, E1242D; ORF9b: P3L"}}},{"name":"AY.4.8","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.8"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-10"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.532318353652954}},"branch_attrs":{"mutations":{"nuc":["C2706T","C11450A","A12124G","G25489T","C29774T"],"ORF1a":["T814I","Q3729K"],"ORF3a":["A33S"]},"labels":{"aa":"ORF1a: T814I, Q3729K; ORF3a: A33S"}}},{"name":"NODE_0000595","node_attrs":{"div":35,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-1.684542179107666}},"branch_attrs":{"mutations":{"nuc":["T17040C"]}},"children":[{"name":"AY.4.1","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-24"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-4.0368428230285645}},"branch_attrs":{"mutations":{"nuc":["C2706T","T18927C","A20374C","G22899T"],"ORF1a":["T814I"],"ORF1b":["I2303L"],"S":["G446V"]},"labels":{"aa":"ORF1a: T814I; ORF1b: I2303L; S: G446V","spike_mutations":"G446V"}}},{"name":"AY.4.6","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.6"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.1065709590911865}},"branch_attrs":{"mutations":{"nuc":["C16293T","C19524T","C20404T","A28967G"],"N":["S232G"],"ORF1b":["P2313S"]},"labels":{"aa":"N: S232G; ORF1b: P2313S"}}},{"name":"AY.4.9","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.9"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-22"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.86684250831604}},"branch_attrs":{"mutations":{"nuc":["C3140T","T4066A","C12513T"],"ORF1a":["P959S","T4083M"]},"labels":{"aa":"ORF1a: P959S, T4083M"}}},{"name":"NODE_0000596","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2"},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.5733251571655273}},"branch_attrs":{"mutations":{"nuc":["T21995C","C22227T","C25614T"],"S":["Y145H","A222V"]},"labels":{"aa":"S: Y145H, A222V","spike_mutations":"Y145H, A222V"}},"children":[{"name":"AY.4.2","node_attrs":{"div":38,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-10-04"},"totalAminoacidSubstitutions":{"value":32},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.5733251571655273}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.2.3","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.3"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-03"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-3.4524967670440674}},"branch_attrs":{"mutations":{"nuc":["G26526T"],"M":["A2S"]},"labels":{"aa":"M: A2S"}}},{"name":"AY.4.2.2","node_attrs":{"div":39,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.2"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-29"},"totalAminoacidSubstitutions":{"value":33},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.774232864379883}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"AY.4.2.1","node_attrs":{"div":42,"clade_display":{"value":"21J (Delta)"},"Nextclade_pango":{"value":"AY.4.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21J"},"clade_who":{"value":"Delta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.617.2.4.2.1"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-11-05"},"totalAminoacidSubstitutions":{"value":34},"clade_nextstrain":{"value":"21J"},"placement_prior":{"value":-2.891268491744995}},"branch_attrs":{"mutations":{"nuc":["C15720T","C18687T","G21668T","G28878T"],"N":["S202I"],"S":["V36F"]},"labels":{"aa":"N: S202I; S: V36F","spike_mutations":"V36F"}}}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000597","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{"nuc":["G28881A","G28882A","G28883C"],"N":["R203K","G204R"]},"labels":{"aa":"N: R203K, G204R","clade":"20B"}},"children":[{"name":"B.1.1","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.111","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.111"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.111"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.088804244995117}},"branch_attrs":{"mutations":{"nuc":["T27447C","T29661C"]}}},{"name":"B.1.1.115","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.115"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.115"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5503621101379395}},"branch_attrs":{"mutations":{"nuc":["G26918T","T29464C"]}}},{"name":"B.1.1.101","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.101"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.101"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.795865058898926}},"branch_attrs":{"mutations":{"nuc":["G8371T","G29868A"],"ORF1a":["Q2702H"]},"labels":{"aa":"ORF1a: Q2702H"}}},{"name":"B.1.1.117","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.117"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.117"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5670976638793945}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"B.1.1.135","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.135"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.135"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.479676723480225}},"branch_attrs":{"mutations":{"nuc":["C10376T"],"ORF1a":["P3371S"]},"labels":{"aa":"ORF1a: P3371S"}}},{"name":"B.1.1.121","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.121"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.121"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.165002346038818}},"branch_attrs":{"mutations":{"nuc":["C27538T"]}}},{"name":"B.1.1.133","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.133"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.133"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4965T","A8072G","A16011G","A21213G"],"ORF1a":["T1567I","N2603D"]},"labels":{"aa":"ORF1a: T1567I, N2603D"}}},{"name":"B.1.1.141","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.141"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.141"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.263731002807617}},"branch_attrs":{"mutations":{"nuc":["T22020C","G26056T"],"ORF3a":["D222Y"],"S":["M153T"]},"labels":{"aa":"ORF3a: D222Y; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.157","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.157"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.157"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.143161773681641}},"branch_attrs":{"mutations":{"nuc":["C6145T","G11272A","C17678T"],"ORF1a":["M3669I"],"ORF1b":["T1404M"]},"labels":{"aa":"ORF1a: M3669I; ORF1b: T1404M"}}},{"name":"B.1.1.161","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.161"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.161"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.087497711181641}},"branch_attrs":{"mutations":{"nuc":["G23403A"],"S":["G614D"]},"labels":{"aa":"S: G614D","spike_mutations":"G614D"}}},{"name":"B.1.1.171","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.171"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.171"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7598371505737305}},"branch_attrs":{"mutations":{"nuc":["C1437T","G29745T"],"ORF1a":["S391F"]},"labels":{"aa":"ORF1a: S391F"}}},{"name":"B.1.1.163","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.163"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.163"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.996797561645508}},"branch_attrs":{"mutations":{"nuc":["G11029A","C21772T","C29518T"]}}},{"name":"B.1.1.174","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.174"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.174"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.569986343383789}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.1.176","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.176"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.176"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.818801164627075}},"branch_attrs":{"mutations":{"nuc":["C8208T","G9267A","T9667C","G25947T","G28361A"],"N":["G30R"],"ORF1a":["T2648I","S3001N"],"ORF3a":["Q185H"],"ORF9b":["M26I"]},"labels":{"aa":"N: G30R; ORF1a: T2648I, S3001N; ORF3a: Q185H; ORF9b: M26I"}}},{"name":"B.1.1.186","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.186"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.186"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.552790641784668}},"branch_attrs":{"mutations":{"nuc":["C4113T","G21974C","C23191T"],"ORF1a":["A1283V"],"S":["D138H"]},"labels":{"aa":"ORF1a: A1283V; S: D138H","spike_mutations":"D138H"}}},{"name":"B.1.1.189","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.189"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.189"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.426567554473877}},"branch_attrs":{"mutations":{"nuc":["C9430T","C12823T"]}}},{"name":"B.1.1.192","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.192"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.192"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.35951042175293}},"branch_attrs":{"mutations":{"nuc":["A1G","C673T"]}}},{"name":"B.1.1.203","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.203"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.203"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.922868251800537}},"branch_attrs":{"mutations":{"nuc":["C23854T"]}}},{"name":"B.1.1.207","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.207"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.207"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.143320560455322}},"branch_attrs":{"mutations":{"nuc":["T9172C","A10948G","C10977T","C23604A","A24874G","G26730T","A26927G"],"M":["V70F"],"ORF1a":["A3571V"],"S":["P681H"]},"labels":{"aa":"M: V70F; ORF1a: A3571V; S: P681H","spike_mutations":"P681H"}}},{"name":"B.1.1.198","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.198"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.198"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.466541767120361}},"branch_attrs":{"mutations":{"nuc":["C3261T","A15984T","C20946T"],"ORF1a":["T999I"]},"labels":{"aa":"ORF1a: T999I"}}},{"name":"B.1.1.205","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.205"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.205"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7890214920043945}},"branch_attrs":{"mutations":{"nuc":["G5539A","G21468A"],"ORF1b":["M2667I"]},"labels":{"aa":"ORF1b: M2667I"}}},{"name":"B.1.1.228","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.228"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.228"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.376809597015381}},"branch_attrs":{"mutations":{"nuc":["A20288G","C21721T","C26894T","C28638A"],"N":["P122H"],"ORF1b":["E2274G"]},"labels":{"aa":"N: P122H; ORF1b: E2274G"}}},{"name":"B.1.1.232","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.232"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.232"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.283544063568115}},"branch_attrs":{"mutations":{"nuc":["T2537G","G12191T","T16479C"],"ORF1a":["L758V","V3976F"]},"labels":{"aa":"ORF1a: L758V, V3976F"}}},{"name":"B.1.1.231","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.231"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.231"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.253881931304932}},"branch_attrs":{"mutations":{"nuc":["A1G","A25505C"],"ORF3a":["Q38P"]},"labels":{"aa":"ORF3a: Q38P"}}},{"name":"B.1.1.253","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.253"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.253"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.5750203132629395}},"branch_attrs":{"mutations":{"nuc":["T19893C"]}}},{"name":"B.1.1.241","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.241"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.241"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.247255802154541}},"branch_attrs":{"mutations":{"nuc":["A11782G","T21570G","C21575T","T25473C","C28253T"],"S":["V3G","L5F"]},"labels":{"aa":"S: V3G, L5F","spike_mutations":"V3G, L5F"}}},{"name":"B.1.1.243","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.243"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.243"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.7952799797058105}},"branch_attrs":{"mutations":{"nuc":["C5339T","A9900C","C12733A"],"ORF1a":["P1692S","N3212T"]},"labels":{"aa":"ORF1a: P1692S, N3212T"}}},{"name":"B.1.1.263","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.263"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.263"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.34738302230835}},"branch_attrs":{"mutations":{"nuc":["G5924A","T21775G"],"ORF1a":["V1887I"]},"labels":{"aa":"ORF1a: V1887I"}}},{"name":"B.1.1.265","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.265"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.265"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.462660312652588}},"branch_attrs":{"mutations":{"nuc":["C11005A","A28624T"],"ORF1a":["H3580Q"]},"labels":{"aa":"ORF1a: H3580Q"}}},{"name":"B.1.1.269","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.269"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.269"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.337713718414307}},"branch_attrs":{"mutations":{"nuc":["C5055T","G11851T","G24812T","C26895T"],"M":["H125Y"],"ORF1a":["T1597I","M3862I"],"S":["D1084Y"]},"labels":{"aa":"M: H125Y; ORF1a: T1597I, M3862I; S: D1084Y","spike_mutations":"D1084Y"}}},{"name":"B.1.1.277","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.277"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.277"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1255927085876465}},"branch_attrs":{"mutations":{"nuc":["A1G","T772C","A2869G","C10868T","G15652T","C29095T"],"ORF1b":["D729Y"]},"labels":{"aa":"ORF1b: D729Y"}}},{"name":"B.1.1.274","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.274"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.274"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.412598133087158}},"branch_attrs":{"mutations":{"nuc":["G25912T"],"ORF3a":["G174C"]},"labels":{"aa":"ORF3a: G174C"}}},{"name":"B.1.1.298","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.298"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.298"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.084219455718994}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22920T","C25936T"],"ORF1b":["T730I"],"ORF3a":["H182Y"],"S":["Y453F"]},"labels":{"aa":"ORF1b: T730I; ORF3a: H182Y; S: Y453F","spike_mutations":"Y453F"}}},{"name":"B.1.1.297","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.297"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.297"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.437381267547607}},"branch_attrs":{"mutations":{"nuc":["A20742C","T27922C"],"ORF1b":["Q2425H"],"ORF8":["I10T"]},"labels":{"aa":"ORF1b: Q2425H; ORF8: I10T"}}},{"name":"B.1.1.294","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.294"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.294"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.174857139587402}},"branch_attrs":{"mutations":{"nuc":["C3373A","C6883T","G21724A"],"ORF1a":["D1036E"]},"labels":{"aa":"ORF1a: D1036E"}}},{"name":"B.1.1.307","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.307"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.307"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8598484992980957}},"branch_attrs":{"mutations":{"nuc":["G1210T","G9802T","G12067T"],"ORF1a":["M315I","M3934I"]},"labels":{"aa":"ORF1a: M315I, M3934I"}}},{"name":"B.1.1.311","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.311"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.311"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8074538707733154}},"branch_attrs":{"mutations":{"nuc":["G11230T","T24088C","G25617T"],"ORF1a":["M3655I"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1a: M3655I; ORF3a: K75N"}}},{"name":"B.1.1.329","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.329"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.329"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.522205352783203}},"branch_attrs":{"mutations":{"nuc":["A2132C","A10323G","G10360A"],"ORF1a":["K623Q","K3353R"]},"labels":{"aa":"ORF1a: K623Q, K3353R"}}},{"name":"B.1.1.348","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.348"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.348"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.965911388397217}},"branch_attrs":{"mutations":{"nuc":["C25521T","C29870A"]}}},{"name":"B.1.1.359","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.359"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.359"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.385677337646484}},"branch_attrs":{"mutations":{"nuc":["A28305G"],"N":["N11S"],"ORF9b":["M8V"]},"labels":{"aa":"N: N11S; ORF9b: M8V"}}},{"name":"B.1.1.37","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.37"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.37"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.5076286792755127}},"branch_attrs":{"mutations":{"nuc":["C21637T","A28169G"]}}},{"name":"B.1.1.368","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.368"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.368"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.436727523803711}},"branch_attrs":{"mutations":{"nuc":["C9996T","G27798T","G29402T"],"N":["D377Y"],"ORF1a":["S3244L"],"ORF7b":["A15S"]},"labels":{"aa":"N: D377Y; ORF1a: S3244L; ORF7b: A15S"}}},{"name":"B.1.1.370","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.370"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.370"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.374","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.374"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.374"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C344A","T1456C","C8595T","C8836T","G11222T","C22792T","T22917A","T26047G"],"ORF1a":["L27I","T2777I","V3653F"],"ORF3a":["L219V"],"S":["L452Q"]},"labels":{"aa":"ORF1a: L27I, T2777I, V3653F; ORF3a: L219V; S: L452Q","spike_mutations":"L452Q"}}},{"name":"B.1.1.376","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.376"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.376"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.826653480529785}},"branch_attrs":{"mutations":{"nuc":["A6716G","G11596T"],"ORF1a":["S2151G","Q3777H"]},"labels":{"aa":"ORF1a: S2151G, Q3777H"}}},{"name":"B.1.1.39","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.39"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9360604286193848}},"branch_attrs":{"mutations":{"nuc":["G9130T","T27319C","G28487A","C28868T"],"N":["V72I","P199S"]},"labels":{"aa":"N: V72I, P199S"}}},{"name":"B.1.1.378","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.378"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.378"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.596437454223633}},"branch_attrs":{"mutations":{"nuc":["C29284T","C29870A"]}}},{"name":"B.1.1.391","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.391"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.391"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.078312397003174}},"branch_attrs":{"mutations":{"nuc":["T7171C","C27002T"]}}},{"name":"B.1.1.398","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.398"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.398"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.419233322143555}},"branch_attrs":{"mutations":{"nuc":["C5806T"]}}},{"name":"B.1.1.409","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.409"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.409"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.411","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.411"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.411"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.413","node_attrs":{"div":16,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.413"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.413"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["A604G","C3096T","G13849T","A19020T","G21974T","G22992A","A26741G","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","C28291T","C29311T"],"M":["I73M"],"ORF1a":["S944L"],"ORF1b":["G128C"],"ORF8":["G66-","S67-","K68E"],"ORF9b":["P3L"],"S":["D138Y","S477N"]},"labels":{"aa":"M: I73M; ORF1a: S944L; ORF1b: G128C; ORF8: G66-, S67-, K68E; ORF9b: P3L; S: D138Y, S477N","spike_mutations":"D138Y, S477N"}}},{"name":"B.1.1.432","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.432"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.432"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.086132526397705}},"branch_attrs":{"mutations":{"nuc":["A6985T","C9319T","C12412T","T14313C"]}}},{"name":"B.1.1.419","node_attrs":{"div":7,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.419"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.419"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.245302438735962}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.420","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.420"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.420"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.130890846252441}},"branch_attrs":{"mutations":{"nuc":["T847C","G3994T","C5178T","C5548T","A11451G","C13694T","T18132C","C21614T","T22882G","A24373G","G25839T","C28310T","T28862A"],"N":["P13S","S197T"],"ORF1a":["T1638I","Q3729R"],"ORF1b":["T76I"],"ORF3a":["W149C"],"S":["L18F","N440K"]},"labels":{"aa":"N: P13S, S197T; ORF1a: T1638I, Q3729R; ORF1b: T76I; ORF3a: W149C; S: L18F, N440K","spike_mutations":"L18F, N440K"}}},{"name":"B.1.1.442","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.442"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.442"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.203185558319092}},"branch_attrs":{"mutations":{"nuc":["A3879-","G3880-","A3881-","T3882-","T3883-","C3884-","C3885-","T3886-","A3887-","A3888-","A3889-","G3890-","A3891-","G3892-","G3893-","A3894-","A3895-","G3896-","T3897-","T3898-","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","A3908-","C13432T","C29409T"],"N":["T379I"],"ORF1a":["E1205-","I1206-","P1207-","K1208-","E1209-","E1210-","V1211-","K1212-","P1213-","F1214-","I1215V"]},"labels":{"aa":"N: T379I; ORF1a: E1205-, I1206-, P1207-, K1208-, E1209-, E1210-, V1211-, K1212-, P1213-, F1214-, I1215V"}}},{"name":"B.1.1.44","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.44"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.44"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.21798849105835}},"branch_attrs":{"mutations":{"nuc":["G28884T"],"N":["R204L"]},"labels":{"aa":"N: R204L"}}},{"name":"B.1.1.485","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.485"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.485"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.884125232696533}},"branch_attrs":{"mutations":{"nuc":["C745T"]}}},{"name":"B.1.1.462","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.462"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.462"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.083774089813232}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.1.487","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.487"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.487"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.523555278778076}},"branch_attrs":{"mutations":{"nuc":["A20374G"],"ORF1b":["I2303V"]},"labels":{"aa":"ORF1b: I2303V"}}},{"name":"B.1.1.500","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.500"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.500"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.359643936157227}},"branch_attrs":{"mutations":{"nuc":["T23689C","C29230T"]}}},{"name":"B.1.1.52","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.52"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.52"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":1},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.163636207580566}},"branch_attrs":{"mutations":{"nuc":["G8T","T9C","A12T","T14222G","T29867A"],"ORF1b":["L252*"]},"labels":{"aa":"ORF1b: L252*"}}},{"name":"B.1.1.525","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.525"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.525"},"totalAminoacidDeletions":{"value":4},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-18"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1C","T2C","T3478G","C8299T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12781T","A16550C","C16887T","C18252T","T21992-","A21993-","T21994-","G23012A","C23525T","A28271C","G28916T"],"N":["G215C"],"ORF1a":["S3675-","G3676-","F3677-"],"ORF1b":["D1028A"],"S":["Y144-","E484K","H655Y"]},"labels":{"aa":"N: G215C; ORF1a: S3675-, G3676-, F3677-; ORF1b: D1028A; S: Y144-, E484K, H655Y","spike_mutations":"Y144-, E484K, H655Y"}}},{"name":"B.1.1.53","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.53"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.53"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.883930683135986}},"branch_attrs":{"mutations":{"nuc":["G9890T","A20318G"],"ORF1a":["A3209S"],"ORF1b":["E2284G"]},"labels":{"aa":"ORF1a: A3209S; ORF1b: E2284G"}}},{"name":"B.1.1.57","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.57"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.57"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.499952793121338}},"branch_attrs":{"mutations":{"nuc":["C20234T"],"ORF1b":["P2256L"]},"labels":{"aa":"ORF1b: P2256L"}}},{"name":"B.1.1.61","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.61"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.61"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.901400566101074}},"branch_attrs":{"mutations":{"nuc":["G18898T"],"ORF1b":["V1811F"]},"labels":{"aa":"ORF1b: V1811F"}}},{"name":"B.1.1.63","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.63"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.63"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.753174304962158}},"branch_attrs":{"mutations":{"nuc":["C21597T","C29144T"],"S":["S12F"]},"labels":{"aa":"S: S12F","spike_mutations":"S12F"}}},{"name":"B.1.1.83","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.83"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.83"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.398312091827393}},"branch_attrs":{"mutations":{"nuc":["C1420T"]}}},{"name":"B.1.1.99","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.99"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.99"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.941136360168457}},"branch_attrs":{"mutations":{"nuc":["C28005T","C29870A"],"ORF8":["P38S"]},"labels":{"aa":"ORF8: P38S"}}},{"name":"B.1.533","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.533"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.533"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.077569961547852}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"NODE_0000598","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.773193359375}},"branch_attrs":{"mutations":{"nuc":["G26211T"]}},"children":[{"name":"AT.1","node_attrs":{"div":32,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.370.1"},"totalAminoacidDeletions":{"value":9},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-19"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1392T","G3281T","A3542G","A5176G","C7005A","T9070C","C9778T","C10029T","A11451G","T12620A","C16985A","G17562T","G19180T","C20759T","C21588T","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","A22206G","A22296C","G23012A","G23900A","C24370T","T25675A","C26568A","G28079T","A28271G"],"M":["L16I"],"ORF1a":["S376L","V1006F","T1093A","T2247N","T3255I","Q3729R","S4119T"],"ORF1b":["T1173N","V1905L","A2431V"],"ORF3a":["L95M"],"S":["P9L","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","D215G","H245P","E484K","E780K"]},"labels":{"aa":"M: L16I; ORF1a: S376L, V1006F, T1093A, T2247N, T3255I, Q3729R, S4119T; ORF1b: T1173N, V1905L, A2431V; ORF3a: L95M; S: P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K","spike_mutations":"P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K"}}},{"name":"B.1.1.404","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.404"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.404"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.654805660247803}},"branch_attrs":{"mutations":{"nuc":["T19275A","G20548T","C26534T"],"ORF1b":["D2361Y"]},"labels":{"aa":"ORF1b: D2361Y"}}}]},{"name":"NODE_0000599","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.10"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.217991828918457}},"branch_attrs":{"mutations":{"nuc":["C19170T","G19509A"]}},"children":[{"name":"B.1.1.10","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.10"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.10"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.217991828918457}},"branch_attrs":{"mutations":{}}},{"name":"L.3","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"L.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.10.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.097334861755371}},"branch_attrs":{"mutations":{"nuc":["C1601T","G4399T","C4543T","G8179T","C8481T","A9453C","C19269T","T22917G","A25026T","G25244T","A26927G"],"ORF1a":["L446F","M1378I","P2739L","Y3063S"],"S":["L452R","Y1155F","V1228L"]},"labels":{"aa":"ORF1a: L446F, M1378I, P2739L, Y3063S; S: L452R, Y1155F, V1228L","spike_mutations":"L452R, Y1155F, V1228L"}}}]},{"name":"NODE_0000600","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.581684589385986}},"branch_attrs":{"mutations":{"nuc":["C9120T"],"ORF1a":["T2952I"]},"labels":{"aa":"ORF1a: T2952I"}},"children":[{"name":"B.1.1.159","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.159"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.159"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.9156622886657715}},"branch_attrs":{"mutations":{"nuc":["G6865T","A9204C","C15237T","C28290T"],"N":["P6L"],"ORF1a":["K2200N","D2980A"],"ORF9b":["P3S"]},"labels":{"aa":"N: P6L; ORF1a: K2200N, D2980A; ORF9b: P3S"}}},{"name":"B.1.1.302","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.302"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.302"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.444321632385254}},"branch_attrs":{"mutations":{"nuc":["C7267T","C18032T","C20233T","G24926T","A27674T","A29350G"],"ORF1b":["T1522I","P2256S"],"ORF7a":["Q94L"],"S":["V1122L"]},"labels":{"aa":"ORF1b: T1522I, P2256S; ORF7a: Q94L; S: V1122L","spike_mutations":"V1122L"}}}]},{"name":"NODE_0000601","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.953939437866211}},"branch_attrs":{"mutations":{"nuc":["C1427T"],"ORF1a":["H388Y"]},"labels":{"aa":"ORF1a: H388Y"}},"children":[{"name":"B.1.1.254","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.254"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.254"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.953939437866211}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.507","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.507"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.507"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.39810848236084}},"branch_attrs":{"mutations":{"nuc":["G1042A","C12253T","G19656A"]}}}]},{"name":"NODE_0000602","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.189764499664307}},"branch_attrs":{"mutations":{"nuc":["G21624T"],"S":["R21I"]},"labels":{"aa":"S: R21I","spike_mutations":"R21I"}},"children":[{"name":"B.1.1.279","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.279"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.279"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.194469451904297}},"branch_attrs":{"mutations":{"nuc":["C1419T","C4158T","C8318A","G18859T"],"ORF1a":["A385V","A1298V","P2685T"],"ORF1b":["A1798S"]},"labels":{"aa":"ORF1a: A385V, A1298V, P2685T; ORF1b: A1798S"}}},{"name":"B.1.1.360","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.360"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.360"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.070791721343994}},"branch_attrs":{"mutations":{"nuc":["G25598T"],"ORF3a":["W69L"]},"labels":{"aa":"ORF3a: W69L"}}}]},{"name":"NODE_0000603","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.919500827789307}},"branch_attrs":{"mutations":{"nuc":["C936T","G3259T"],"ORF1a":["T224I","Q998H"]},"labels":{"aa":"ORF1a: T224I, Q998H"}},"children":[{"name":"B.1.1.304","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.304"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.304"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.919500827789307}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.434","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.434"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.434"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2342G","C11591T","G17122T","C18348T","A26069G"],"ORF1a":["I693V","L3776F"],"ORF1b":["A1219S"],"ORF3a":["E226G"]},"labels":{"aa":"ORF1a: I693V, L3776F; ORF1b: A1219S; ORF3a: E226G"}}}]},{"name":"NODE_0000604","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986992835998535}},"branch_attrs":{"mutations":{"nuc":["C25528T"],"ORF3a":["L46F"]},"labels":{"aa":"ORF3a: L46F"}},"children":[{"name":"B.1.1.326","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.326"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.326"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.312770843505859}},"branch_attrs":{"mutations":{"nuc":["A12C","G4354A","C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}}},{"name":"B.1.1.8","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.8"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986992835998535}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000605","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.15211820602417}},"branch_attrs":{"mutations":{"nuc":["G16853T"],"ORF1b":["G1129V"]},"labels":{"aa":"ORF1b: G1129V"}},"children":[{"name":"B.1.1.34","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.34"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.34"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.187512397766113}},"branch_attrs":{"mutations":{"nuc":["C2094T"],"ORF1a":["S610L"]},"labels":{"aa":"ORF1a: S610L"}}},{"name":"B.1.1.382","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.382"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.382"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.577414035797119}},"branch_attrs":{"mutations":{"nuc":["G6368A"],"ORF1a":["G2035R"]},"labels":{"aa":"ORF1a: G2035R"}}}]},{"name":"NODE_0000606","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.365635395050049}},"branch_attrs":{"mutations":{"nuc":["G28077T"],"ORF8":["V62L"]},"labels":{"aa":"ORF8: V62L"}},"children":[{"name":"B.1.1.397","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.397"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.397"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4799723625183105}},"branch_attrs":{"mutations":{"nuc":["G21974T","T22020C","G28975T"],"N":["M234I"],"S":["D138Y","M153T"]},"labels":{"aa":"N: M234I; S: D138Y, M153T","spike_mutations":"D138Y, M153T"}}},{"name":"B.1.1.526","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.526"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.526"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-25"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-8.3259916305542}},"branch_attrs":{"mutations":{"nuc":["G4510T","C8917T","G9389A","C9611T","G12167T","G14622A","C23604A","T24811C","G25250T","G25906T","C29659T"],"ORF1a":["D3042N","L3116F","V3968F"],"ORF3a":["G172C"],"S":["P681H","V1230L"]},"labels":{"aa":"ORF1a: D3042N, L3116F, V3968F; ORF3a: G172C; S: P681H, V1230L","spike_mutations":"P681H, V1230L"}}}]},{"name":"NODE_0000607","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.675731658935547}},"branch_attrs":{"mutations":{"nuc":["T12503C","C29721T"],"ORF1a":["Y4080H"]},"labels":{"aa":"ORF1a: Y4080H"}},"children":[{"name":"B.1.1.448","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.448"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.448"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.675731658935547}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.54","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.54"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.54"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.6780924797058105}},"branch_attrs":{"mutations":{"nuc":["C6762T","G25770T"],"ORF1a":["T2166I"],"ORF3a":["R126S"]},"labels":{"aa":"ORF1a: T2166I; ORF3a: R126S"}}}]},{"name":"NODE_0000608","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.731308460235596}},"branch_attrs":{"mutations":{"nuc":["C21648T"],"S":["T29I"]},"labels":{"aa":"S: T29I","spike_mutations":"T29I"}},"children":[{"name":"B.1.1.486","node_attrs":{"div":19,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.486"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.486"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["C12439T","C23277T","G23593T","G24368A","G25565A","C25624T","T27242C","C27630T","G28975T","G29332T","G29751T"],"N":["M234I"],"ORF3a":["S58N","H78Y"],"ORF6":["I14T"],"S":["T572I","Q677H","D936N"]},"labels":{"aa":"N: M234I; ORF3a: S58N, H78Y; ORF6: I14T; S: T572I, Q677H, D936N","spike_mutations":"T572I, Q677H, D936N"}}},{"name":"B.1.1.67","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.67"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.67"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.89309549331665}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"ORF1a":["D3728N"]},"labels":{"aa":"ORF1a: D3728N"}}}]},{"name":"NODE_0000609","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.003873348236084}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"ORF1b":["S997P"]},"labels":{"aa":"ORF1b: S997P"}},"children":[{"name":"B.1.1.371","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.371"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.371"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.003873348236084}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000610","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-7.580465316772461}},"branch_attrs":{"mutations":{"nuc":["C13887T","C23248T"]}},"children":[{"name":"B.1.1.153","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.153"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.153"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C1912T","T9151C","C9693T"],"ORF1a":["A3143V"]},"labels":{"aa":"ORF1a: A3143V"}}},{"name":"B.1.1.170","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.170"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.170"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.357182025909424}},"branch_attrs":{"mutations":{"nuc":["C2062T","C5184A","C16456T","C18687T"],"ORF1a":["P1640H"],"ORF1b":["P997S"]},"labels":{"aa":"ORF1a: P1640H; ORF1b: P997S"}}}]}]},{"name":"NODE_0000611","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.207353591918945}},"branch_attrs":{"mutations":{"nuc":["C26060T"],"ORF3a":["T223I"]},"labels":{"aa":"ORF3a: T223I"}},"children":[{"name":"B.1.1.216","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.216"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.216"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.874288558959961}},"branch_attrs":{"mutations":{"nuc":["A1T","C5884T"]}}},{"name":"B.1.1.416","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.416"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.416"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.053168773651123}},"branch_attrs":{"mutations":{"nuc":["C16386T","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"B.1.1.433","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.433"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.433"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.377383232116699}},"branch_attrs":{"mutations":{"nuc":["C313T","G3692T","C5007T","A11991G","G14584A","C14805T","T15114C","C15848T","G20940T","C22993G","G23580C","T23599A","G26217T","G26951C","T27900C"],"ORF1a":["V1143F","T1581M","E3909G"],"ORF1b":["A373T","T794I"],"ORF3a":["L275F"],"ORF8":["F3L"],"S":["S477R","S673T","N679K"]},"labels":{"aa":"ORF1a: V1143F, T1581M, E3909G; ORF1b: A373T, T794I; ORF3a: L275F; ORF8: F3L; S: S477R, S673T, N679K","spike_mutations":"S477R, S673T, N679K"}}}]},{"name":"NODE_0000612","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.322074890136719}},"branch_attrs":{"mutations":{"nuc":["G10265A"],"ORF1a":["G3334S"]},"labels":{"aa":"ORF1a: G3334S"}},"children":[{"name":"B.1.1.27","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.27"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.27"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.765736103057861}},"branch_attrs":{"mutations":{"nuc":["C16293T"]}}},{"name":"B.1.1.301","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.301"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.301"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.301371097564697}},"branch_attrs":{"mutations":{"nuc":["A9433T","A19650G"]}}},{"name":"B.1.1.70","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.70"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.70"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.566112756729126}},"branch_attrs":{"mutations":{"nuc":["A15972G","C19718T","T28759C"],"ORF1b":["T2084I"]},"labels":{"aa":"ORF1b: T2084I"}}}]},{"name":"NODE_0000613","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.842899322509766}},"branch_attrs":{"mutations":{"nuc":["C22675T"]}},"children":[{"name":"B.1.1.273","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.273"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.273"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.872927665710449}},"branch_attrs":{"mutations":{"nuc":["A7064G"],"ORF1a":["R2267G"]},"labels":{"aa":"ORF1a: R2267G"}}},{"name":"B.1.1.412","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.412"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.412"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.986691951751709}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"ORF1a":["D3728N"]},"labels":{"aa":"ORF1a: D3728N"}}},{"name":"B.1.1.56","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.56"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.56"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.680346488952637}},"branch_attrs":{"mutations":{"nuc":["T9508C","G23868T","G24794T"],"S":["G769V","A1078S"]},"labels":{"aa":"S: G769V, A1078S","spike_mutations":"G769V, A1078S"}}}]},{"name":"NODE_0000614","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879861831665039}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"ORF1a":["L3606F"]},"labels":{"aa":"ORF1a: L3606F"}},"children":[{"name":"B.1.1.312","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.312"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.312"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420843601226807}},"branch_attrs":{"mutations":{"nuc":["C2455T","C14625T","C19018T","A24432T","A28081G"],"ORF1b":["P1851S"],"ORF8":["D63G"],"S":["Q957L"]},"labels":{"aa":"ORF1b: P1851S; ORF8: D63G; S: Q957L","spike_mutations":"Q957L"}}},{"name":"B.1.1.406","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.406"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.406"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.854406833648682}},"branch_attrs":{"mutations":{"nuc":["C683T","C7051T","C7303T","C8964T","G25314T","C29296T","G29744A"],"ORF1a":["S2900L"],"S":["G1251V"]},"labels":{"aa":"ORF1a: S2900L; S: G1251V","spike_mutations":"G1251V"}}},{"name":"B.1.1.417","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.417"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.417"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.553449630737305}},"branch_attrs":{"mutations":{"nuc":["A2871G","C11455T","T12433C","C16997T","C17285T","A17739G","C19017T","G19072T","C20823T","G21800T","C25416T","G29781T"],"ORF1a":["N869S"],"ORF1b":["P1177L","S1273L","D1869Y"],"S":["D80Y"]},"labels":{"aa":"ORF1a: N869S; ORF1b: P1177L, S1273L, D1869Y; S: D80Y","spike_mutations":"D80Y"}}}]},{"name":"NODE_0000615","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.0597028732299805}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}},"children":[{"name":"B.1.1.351","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.351"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.351"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C7231T","A9749G","C10776A","A13867C","A15489G","C16658T","G17815A","C19164T","G21724T","C23604A"],"ORF1a":["K3162E","P3504H"],"ORF1b":["K134Q","T1064I","G1450R"],"S":["L54F","P681H"]},"labels":{"aa":"ORF1a: K3162E, P3504H; ORF1b: K134Q, T1064I, G1450R; S: L54F, P681H","spike_mutations":"L54F, P681H"}}},{"name":"B.1.1.354","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.354"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.354"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.894475221633911}},"branch_attrs":{"mutations":{"nuc":["A1T","G9389A","G28899T"],"N":["R209I"],"ORF1a":["D3042N"]},"labels":{"aa":"N: R209I; ORF1a: D3042N"}}},{"name":"B.1.1.46","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.46"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.46"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.3985700607299805}},"branch_attrs":{"mutations":{"nuc":["A1C","C1218T","C27110T","T27384C"],"ORF1a":["S318L"]},"labels":{"aa":"ORF1a: S318L"}}}]},{"name":"NODE_0000616","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.25"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1366167068481445}},"branch_attrs":{"mutations":{"nuc":["A1G","A1163T"],"ORF1a":["I300F"]},"labels":{"aa":"ORF1a: I300F"}},"children":[{"name":"B.1.1.25","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.25"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.25"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.1366167068481445}},"branch_attrs":{"mutations":{}}},{"name":"D.2","node_attrs":{"div":14,"clade_display":{"value":"20F"},"Nextclade_pango":{"value":"D.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20F"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.25.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20F"},"placement_prior":{"value":-3.0833330154418945}},"branch_attrs":{"mutations":{"nuc":["T7540C","G16647T","C18555T","G22992A","G23401A"],"S":["S477N"]},"labels":{"aa":"S: S477N","clade":"20F","spike_mutations":"S477N"}}},{"name":"NODE_0000617","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.315"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{"nuc":["G1A","T3256C","G14202T","C19718T","C22388T","C26060T","G29227T","C29466T","A29771G"],"N":["A398V"],"ORF1b":["E245D","T2084I"],"ORF3a":["T223I"]},"labels":{"aa":"N: A398V; ORF1b: E245D, T2084I; ORF3a: T223I"}},"children":[{"name":"AD.2","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.315.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.5890538692474365}},"branch_attrs":{"mutations":{"nuc":["C5622T","G19542T"],"ORF1a":["P1786L"],"ORF1b":["M2025I"]},"labels":{"aa":"ORF1a: P1786L; ORF1b: M2025I"}}},{"name":"B.1.1.315","node_attrs":{"div":18,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.315"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.315"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000618","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.33"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8492207527160645}},"branch_attrs":{"mutations":{"nuc":["T27299C","T29148C"],"N":["I292T"],"ORF6":["I33T"]},"labels":{"aa":"N: I292T; ORF6: I33T"}},"children":[{"name":"B.1.1.33","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.33"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8492207527160645}},"branch_attrs":{"mutations":{}}},{"name":"N.3","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.3"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.3"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.3295159339904785}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"N.4","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.656519889831543}},"branch_attrs":{"mutations":{"nuc":["A1C","A2475G"],"ORF1a":["K737R"]},"labels":{"aa":"ORF1a: K737R"}}},{"name":"N.5","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A298G","C17274T","A22803G","C25904T","G29134A"],"ORF3a":["S171L"],"S":["Q414R"]},"labels":{"aa":"ORF3a: S171L; S: Q414R","spike_mutations":"Q414R"}}},{"name":"N.6","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.9203901290893555}},"branch_attrs":{"mutations":{"nuc":["C5365T","G8137T"]}}},{"name":"N.9","node_attrs":{"div":16,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"N.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.33.9"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["G1264T","C7600T","C7851T","T11078C","G23012A","A27853C","A29882C"],"ORF1a":["A2529V","F3605L"],"ORF7b":["E33A"],"S":["E484K"]},"labels":{"aa":"ORF1a: A2529V, F3605L; ORF7b: E33A; S: E484K","spike_mutations":"E484K"}}}]},{"name":"NODE_0000619","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.563066005706787}},"branch_attrs":{"mutations":{"nuc":["G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.1.523","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.523"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.523"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-16"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["A1087G","A1610G","A2311G","A2969G","G6609T","C9430T","G10961A","G11222T","C13356T","G14126A","C16466T","G16917A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22035-","A22036-","T22478C","T23042C","A23901C","A24078T","C24642T","C25904T","G25993T","A28273T","G28907T"],"N":["G212C"],"ORF1a":["N449D","M902V","R2115I","V3566I","V3653F","T4364I"],"ORF1b":["S220N","P1000L"],"ORF3a":["S171L","V201F"],"S":["E156-","F157-","R158-","F306L","S494P","E780A","D839V","T1027I"]},"labels":{"aa":"N: G212C; ORF1a: N449D, M902V, R2115I, V3566I, V3653F, T4364I; ORF1b: S220N, P1000L; ORF3a: S171L, V201F; S: E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I","spike_mutations":"E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I"}}},{"name":"NODE_0000620","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1T","C3961T","G7798T","C9072T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G20578A","C21846T","T21992-","A21993-","T21994-","T23287C","C23604A","G23948C","C25276A","A27887-","A27888-","C27889-","G27890-","A27891-","A27892-","C27893-","A27894-","T27895-","G27896-","A27897-","A27898-","A27899-","T27900-","T27901-","G28209T","A28271G","C28896-","T28897-","A28898-","C29769T"],"N":["A208-","R209G"],"ORF1a":["K2511N","T2936I","A3209V","S3675-","G3676-","F3677-"],"ORF1b":["V2371M"],"ORF8":["E106*"],"S":["T95I","Y144-","P681H","D796H"]},"labels":{"aa":"N: A208-, R209G; ORF1a: K2511N, T2936I, A3209V, S3675-, G3676-, F3677-; ORF1b: V2371M; ORF8: E106*; S: T95I, Y144-, P681H, D796H","spike_mutations":"T95I, Y144-, P681H, D796H"}},"children":[{"name":"AZ.4","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.4"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":17},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2416T","G7829C","T7831A","C17569T","T27384C"],"ORF1a":["V2522L"],"ORF1b":["P1368S"]},"labels":{"aa":"ORF1a: V2522L; ORF1b: P1368S"}}},{"name":"NODE_0000621","node_attrs":{"div":24,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C24382T"]}},"children":[{"name":"AZ.5","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.5"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T1G","G3259T","G6463T","T20994C","C29077T","A29879G"],"ORF1a":["Q998H"]},"labels":{"aa":"ORF1a: Q998H"}}},{"name":"NODE_0000622","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.047728061676025}},"branch_attrs":{"mutations":{"nuc":["C10116T"],"ORF1a":["T3284I"]},"labels":{"aa":"ORF1a: T3284I"}},"children":[{"name":"B.1.1.318","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.047728061676025}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000623","node_attrs":{"div":27,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.318"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9889705181121826}},"branch_attrs":{"mutations":{"nuc":["A3852T","G21004T"],"ORF1a":["E1196V"],"ORF1b":["A2513S"]},"labels":{"aa":"ORF1a: E1196V; ORF1b: A2513S"}},"children":[{"name":"AZ.1","node_attrs":{"div":29,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.1"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.071262836456299}},"branch_attrs":{"mutations":{"nuc":["C11345T","C11644T"],"ORF1a":["L3694F"]},"labels":{"aa":"ORF1a: L3694F"}}},{"name":"AZ.2","node_attrs":{"div":30,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.2"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.056198596954346}},"branch_attrs":{"mutations":{"nuc":["C10369T","C12400T","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"AZ.3","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AZ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.318.3"},"totalAminoacidDeletions":{"value":8},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-07"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["T11850C"],"ORF1a":["M3862T"]},"labels":{"aa":"ORF1a: M3862T"}}}]}]}]}]}]},{"name":"NODE_0000624","node_attrs":{"div":28,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.706334114074707}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14676T","C15279T","T16176C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23271A","C23604A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF1a":["T1001I","A1708D","I2230T","S3675-","G3676-","F3677-"],"ORF8":["Q27*","R52I","Y73C"],"S":["H69-","V70-","Y144-","N501Y","A570D","P681H","T716I","S982A","D1118H"]},"labels":{"aa":"N: D3L, S235F; ORF1a: T1001I, A1708D, I2230T, S3675-, G3676-, F3677-; ORF8: Q27*, R52I, Y73C; S: H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H","clade":"Alpha","spike_mutations":"H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":28,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.706334114074707}},"branch_attrs":{"mutations":{}}},{"name":"Q.1","node_attrs":{"div":29,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.1"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-02"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.273845911026001}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}}},{"name":"Q.2","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.2"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-02"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.9566643238067627}},"branch_attrs":{"mutations":{"nuc":["A1752G","C6636T","G22468T","C25626T","C27752T","C28227T"],"ORF1a":["Y496C","T2124I"],"ORF7a":["T120I"],"ORF8":["H112Y"]},"labels":{"aa":"ORF1a: Y496C, T2124I; ORF7a: T120I; ORF8: H112Y"}}},{"name":"NODE_0000625","node_attrs":{"div":29,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.8349618911743164}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"ORF1b":["K1383R"]},"labels":{"aa":"ORF1b: K1383R"}},"children":[{"name":"Q.3","node_attrs":{"div":33,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.3"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-03"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.3964552879333496}},"branch_attrs":{"mutations":{"nuc":["G5023A","G10396T","G20962A","G26730C"],"M":["V70L"],"ORF1a":["M1586I"],"ORF1b":["D2499N"]},"labels":{"aa":"M: V70L; ORF1a: M1586I; ORF1b: D2499N"}}},{"name":"Q.4","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.4"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.756404399871826}},"branch_attrs":{"mutations":{"nuc":["C335T","A4964G","C7224T","A12162G","A23604G"],"ORF1a":["R24C","T1567A","A2320V","Q3966R"],"S":["H681R"]},"labels":{"aa":"ORF1a: R24C, T1567A, A2320V, Q3966R; S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000626","node_attrs":{"div":30,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"B.1.1.7"},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-1.7612149715423584}},"branch_attrs":{"mutations":{"nuc":["T15096C","A28095T"],"ORF8":["K68*"]},"labels":{"aa":"ORF8: K68*"}},"children":[{"name":"Q.7","node_attrs":{"div":34,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.7"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-22"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-3.1349854469299316}},"branch_attrs":{"mutations":{"nuc":["A7069C","A17337G","T18018C","G28884C"],"N":["R204P"],"ORF1a":["E2268D"]},"labels":{"aa":"N: R204P; ORF1a: E2268D"}}},{"name":"Q.8","node_attrs":{"div":35,"clade_display":{"value":"20I (Alpha)"},"Nextclade_pango":{"value":"Q.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20I"},"clade_who":{"value":"Alpha"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.7.8"},"totalAminoacidDeletions":{"value":6},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-22"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20I"},"placement_prior":{"value":-4.827495098114014}},"branch_attrs":{"mutations":{"nuc":["C12525T","C19164T","C25096T","A25974C","G29751T"],"ORF1a":["T4087I"],"ORF3a":["E194D"]},"labels":{"aa":"ORF1a: T4087I; ORF3a: E194D"}}}]}]},{"name":"NODE_0000627","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.3056695461273193}},"branch_attrs":{"mutations":{"nuc":["C313T"]}},"children":[{"name":"B.1.1.181","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.181"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.181"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.882154941558838}},"branch_attrs":{"mutations":{"nuc":["C14724T"]}}},{"name":"B.1.1.214","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.214"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.214"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-2.8961265087127686}},"branch_attrs":{"mutations":{"nuc":["C18167T","G21518T","G28975T"],"N":["M234I"],"ORF1b":["P1567L","R2684I"]},"labels":{"aa":"N: M234I; ORF1b: P1567L, R2684I"}}},{"name":"B.1.1.305","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.305"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.305"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.705223083496094}},"branch_attrs":{"mutations":{"nuc":["G28396A"],"ORF9b":["G38D"]},"labels":{"aa":"ORF9b: G38D"}}},{"name":"B.1.1.50","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.50"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.50"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.180130958557129}},"branch_attrs":{"mutations":{"nuc":["G4510A","G15438T","G25785T"],"ORF1b":["M657I"],"ORF3a":["W131C"]},"labels":{"aa":"ORF1b: M657I; ORF3a: W131C"}}},{"name":"B.1.1.51","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.51"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.51"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.485178470611572}},"branch_attrs":{"mutations":{"nuc":["T10453C","C11195T"],"ORF1a":["L3644F"]},"labels":{"aa":"ORF1a: L3644F"}}},{"name":"NODE_0000628","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.781398296356201}},"branch_attrs":{"mutations":{"nuc":["C9286T"]}},"children":[{"name":"B.1.1.284","node_attrs":{"div":14,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.284"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.284"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.229825973510742}},"branch_attrs":{"mutations":{"nuc":["T4346C","C10376T","C14708T","C28725T","G29692T"],"N":["P151L"],"ORF1a":["S1361P","P3371S"],"ORF1b":["A414V"]},"labels":{"aa":"N: P151L; ORF1a: S1361P, P3371S; ORF1b: A414V"}}},{"name":"B.1.1.47","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.47"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.47"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.771064281463623}},"branch_attrs":{"mutations":{"nuc":["C19763T"],"ORF1b":["T2099I"]},"labels":{"aa":"ORF1b: T2099I"}}}]},{"name":"NODE_0000629","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.306"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.095082759857178}},"branch_attrs":{"mutations":{"nuc":["A1C","C5700A"],"ORF1a":["A1812D"]},"labels":{"aa":"ORF1a: A1812D"}},"children":[{"name":"AE.8","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AE.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306.8"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.943758726119995}},"branch_attrs":{"mutations":{"nuc":["C1347T","C1943T","C6031T","T7153C","G13975T"],"ORF1a":["P361L","R560C"],"ORF1b":["G170C"]},"labels":{"aa":"ORF1a: P361L, R560C; ORF1b: G170C"}}},{"name":"AE.1","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"AE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.027614116668701}},"branch_attrs":{"mutations":{"nuc":["C25791T"]}}},{"name":"B.1.1.306","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.306"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.306"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.095082759857178}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000630","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.462162494659424}},"branch_attrs":{"mutations":{"nuc":["T19839C"]}},"children":[{"name":"B.1.1.221","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.221"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.221"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.094874382019043}},"branch_attrs":{"mutations":{"nuc":["C21646T","C26846T"]}}},{"name":"B.1.1.220","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.220"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.220"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.653388977050781}},"branch_attrs":{"mutations":{"nuc":["C26681T"]}}},{"name":"B.1.1.291","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.291"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.291"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.9558887481689453}},"branch_attrs":{"mutations":{"nuc":["C15933T","C29784T"]}}},{"name":"B.1.1.317","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.317"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.317"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8059520721435547}},"branch_attrs":{"mutations":{"nuc":["C28905T"],"N":["A211V"]},"labels":{"aa":"N: A211V"}}},{"name":"B.1.1.459","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.459"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.459"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.984232425689697}},"branch_attrs":{"mutations":{"nuc":["C16971T","A21137G","C24099T"],"ORF1b":["K2557R"],"S":["A846V"]},"labels":{"aa":"ORF1b: K2557R; S: A846V","spike_mutations":"A846V"}}},{"name":"B.1.1.464","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.464"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.464"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":4},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.0467987060546875}},"branch_attrs":{"mutations":{"nuc":["C12025T","C23707T"]}}},{"name":"B.1.1.521","node_attrs":{"div":12,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.521"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.521"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.155290126800537}},"branch_attrs":{"mutations":{"nuc":["C4927T","C9693T","C18744T","C23422T"],"ORF1a":["A3143V"]},"labels":{"aa":"ORF1a: A3143V"}}},{"name":"R.1","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"R.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.316.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.1175601482391357}},"branch_attrs":{"mutations":{"nuc":["C14340T","G17551A","C18877T","A19167G","C19274A","G22017T","G23012A","G23868T","T26604C","C27213T","C28833T","G29527T"],"M":["F28L"],"N":["S187L","Q418H"],"ORF1b":["G1362R","P1936H"],"S":["W152L","E484K","G769V"]},"labels":{"aa":"M: F28L; N: S187L, Q418H; ORF1b: G1362R, P1936H; S: W152L, E484K, G769V","spike_mutations":"W152L, E484K, G769V"}}},{"name":"NODE_0000631","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{"nuc":["A23756G"],"S":["T732A"]},"labels":{"aa":"S: T732A","spike_mutations":"T732A"}},"children":[{"name":"B.1.1.222","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.222"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.222"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000632","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.879711866378784}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.1.1.316","node_attrs":{"div":13,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.316"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.316"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.084819793701172}},"branch_attrs":{"mutations":{"nuc":["C21757T","G23593C","G23756T","G29751T"],"S":["Q677H","A732S"]},"labels":{"aa":"S: Q677H, A732S","spike_mutations":"Q677H, A732S"}}},{"name":"B.1.1.418","node_attrs":{"div":17,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.418"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.418"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["C1812T","A8072G","A10323G","A21194G","C22480T","G24197T","G24415T","G29751C"],"ORF1a":["A516V","N2603D","K3353R"],"ORF1b":["D2576G"],"S":["A879S"]},"labels":{"aa":"ORF1a: A516V, N2603D, K3353R; ORF1b: D2576G; S: A879S","spike_mutations":"A879S"}}}]}]}]},{"name":"NODE_0000633","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.308648586273193}},"branch_attrs":{"mutations":{"nuc":["G10097A","C23731T"],"ORF1a":["G3278S"]},"labels":{"aa":"ORF1a: G3278S"}},"children":[{"name":"B.1.1.369","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.369"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.369"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7873337268829346}},"branch_attrs":{"mutations":{"nuc":["G28580T"],"N":["D103Y"]},"labels":{"aa":"N: D103Y"}}},{"name":"B.1.1.372","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.372"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.372"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.308648586273193}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000634","node_attrs":{"div":12,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-3.7463936805725098}},"branch_attrs":{"mutations":{"nuc":["A1G","C4002T","C13536T"],"ORF1a":["T1246I"]},"labels":{"aa":"ORF1a: T1246I","clade":"20D"}},"children":[{"name":"B.1.1.1","node_attrs":{"div":12,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-3.7463936805725098}},"branch_attrs":{"mutations":{}}},{"name":"C.11","node_attrs":{"div":16,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.11"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.11"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.6986260414123535}},"branch_attrs":{"mutations":{"nuc":["T3G","T8071C","G13201A","C27804T"]}}},{"name":"C.13","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.13"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.13"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.601921081542969}},"branch_attrs":{"mutations":{"nuc":["A21131G"],"ORF1b":["Q2555R"]},"labels":{"aa":"ORF1b: Q2555R"}}},{"name":"C.14","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.14"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.14"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.61112642288208}},"branch_attrs":{"mutations":{"nuc":["G29179T"]}}},{"name":"C.26","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.26"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.097334861755371}},"branch_attrs":{"mutations":{"nuc":["G1T","T8278C","G12661A","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-","A29866-","T29867-","G29868-","A29869-","C29870-","A29871-","A29872-","A29873-"]}}},{"name":"C.29","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.29"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.6840291023254395}},"branch_attrs":{"mutations":{"nuc":["T27900C"],"ORF8":["F3L"]},"labels":{"aa":"ORF8: F3L"}}},{"name":"C.23","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.23"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.90360689163208}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}}},{"name":"C.32","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.32"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.39810848236084}},"branch_attrs":{"mutations":{"nuc":["C14877T"]}}},{"name":"C.33","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.33"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":6},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.331234931945801}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}}},{"name":"C.35","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.35"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.0755510330200195}},"branch_attrs":{"mutations":{"nuc":["G1T","G5950T","G19732T"],"ORF1a":["K1895N"],"ORF1b":["V2089F"]},"labels":{"aa":"ORF1a: K1895N; ORF1b: V2089F"}}},{"name":"C.38","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.38"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-28"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A4307C","C4763T","C5812T","G6609T","A9103C","C9286T","A11201G","G11417T","C19862T","C21057T","C21727T","T21752A","G23012A","G23948T","T26112C","T26767C","C27925A","C28311T","C28905T","G29405C"],"M":["I82T"],"N":["P13L","A211V","E378Q"],"ORF1a":["K1348Q","H1500Y","R2115I","E2946D","T3646A","V3718F"],"ORF1b":["A2132V"],"ORF8":["T11K"],"ORF9b":["P10S"],"S":["W64R","E484K","D796Y"]},"labels":{"aa":"M: I82T; N: P13L, A211V, E378Q; ORF1a: K1348Q, H1500Y, R2115I, E2946D, T3646A, V3718F; ORF1b: A2132V; ORF8: T11K; ORF9b: P10S; S: W64R, E484K, D796Y","spike_mutations":"W64R, E484K, D796Y"}}},{"name":"C.4","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.4"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["A4G","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"NODE_0000635","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.439589977264404}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"C.16","node_attrs":{"div":16,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.16"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.16"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.2959184646606445}},"branch_attrs":{"mutations":{"nuc":["G3302A","C9693T","G29422T"],"ORF1a":["E1013K","A3143V"]},"labels":{"aa":"ORF1a: E1013K, A3143V"}}},{"name":"C.40","node_attrs":{"div":23,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"20D"},"qc.frameShifts.frameShifts":{"value":"S:245-246"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"S:245-246,ORF3a:258-276"},"partiallyAliased":{"value":"B.1.1.1.40"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-27"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2094T","A3069G","C9891T","A10982G","A12820G","C16466T","G22205C","T22292-","G22299-","A22300-","A22301-","G22302-","T22303-","C23481T","C24138A","A26161-","A28271-","G28917T"],"N":["G215V"],"ORF1a":["S610L","D935G","A3209V","K3573E"],"ORF1b":["P1000L"],"ORF3a":["N257-"],"S":["D215H","L244-","S247-","S640F","T859N"]},"labels":{"aa":"N: G215V; ORF1a: S610L, D935G, A3209V, K3573E; ORF1b: P1000L; ORF3a: N257-; S: D215H, L244-, S247-, S640F, T859N","spike_mutations":"D215H, L244-, S247-, S640F, T859N"}}}]},{"name":"NODE_0000636","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.998632907867432}},"branch_attrs":{"mutations":{"nuc":["T14345C","G18292T"],"ORF1b":["L293S","A1609S"]},"labels":{"aa":"ORF1b: L293S, A1609S"}},"children":[{"name":"C.2","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.998632907867432}},"branch_attrs":{"mutations":{}}},{"name":"C.2.1","node_attrs":{"div":22,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.2.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":12},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.745294570922852}},"branch_attrs":{"mutations":{"nuc":["G922T","T8323C","T15437C","C18501T","A23064C","C25624T","C28453T","C29642T"],"ORF1b":["M657T"],"ORF3a":["H78Y"],"ORF9b":["A57V"],"S":["N501T"]},"labels":{"aa":"ORF1b: M657T; ORF3a: H78Y; ORF9b: A57V; S: N501T","spike_mutations":"N501T"}}}]},{"name":"NODE_0000637","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.791934013366699}},"branch_attrs":{"mutations":{"nuc":["C18747T","G29425T"],"N":["Q384H"]},"labels":{"aa":"N: Q384H"}},"children":[{"name":"B.1.1.375","node_attrs":{"div":23,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.375"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.375"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.2221879959106445}},"branch_attrs":{"mutations":{"nuc":["G1A","C2509T","T4002C","C6781T","A10097G","G17027T","G22992A","A23233G","G28048A"],"ORF1a":["I1246T","S3278G"],"ORF1b":["S1187I"],"ORF8":["R52K"],"S":["S477N"]},"labels":{"aa":"ORF1a: I1246T, S3278G; ORF1b: S1187I; ORF8: R52K; S: S477N","spike_mutations":"S477N"}}},{"name":"C.1","node_attrs":{"div":14,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.1"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.791934013366699}},"branch_attrs":{"mutations":{}}},{"name":"C.1.2","node_attrs":{"div":30,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.1.2"},"totalAminoacidDeletions":{"value":5},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["G569A","C2485T","C5175T","A7699G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21969T","G22132T","A22206G","C22210T","G22289-","C22290-","T22291-","T22907C","G23012A","A23063T","C23525T","T23599A","C23709T","G26155-","T26156-","T26157-","C28311T","T28516C"],"N":["P13L"],"ORF1a":["E102K","T1637I","S3675-","G3676-","F3677-"],"ORF3a":["V255-"],"ORF9b":["P10S","M78T"],"S":["C136F","R190S","D215G","A243-","Y449H","E484K","N501Y","H655Y","N679K","T716I"]},"labels":{"aa":"N: P13L; ORF1a: E102K, T1637I, S3675-, G3676-, F3677-; ORF3a: V255-; ORF9b: P10S, M78T; S: C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I","spike_mutations":"C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I"}}}]},{"name":"NODE_0000638","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.54981803894043}},"branch_attrs":{"mutations":{"nuc":["G28908T"],"N":["G212V"]},"labels":{"aa":"N: G212V"}},"children":[{"name":"C.36","node_attrs":{"div":13,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":7},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.54981803894043}},"branch_attrs":{"mutations":{}}},{"name":"internal_9cca","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G569A","C2841T","G5180A","C7124T","G9203A","G9929A","C11325T","T11337C","C12534T","G16549T","C17766T","C21597T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22016A","A22600C","T22917G","G23593T","G24257T","T26767C","G27882T","A28271-"],"M":["I82T"],"ORF1a":["E102K","A859V","D1639N","P2287S","D2980N","D3222N","S3687L","L3691S","T4090I"],"ORF1b":["D1028Y"],"ORF7b":["A43S"],"S":["S12F","H69-","V70-","W152R","R346S","L452R","Q677H","A899S"]},"labels":{"aa":"M: I82T; ORF1a: E102K, A859V, D1639N, P2287S, D2980N, D3222N, S3687L, L3691S, T4090I; ORF1b: D1028Y; ORF7b: A43S; S: S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S","spike_mutations":"S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S"}},"children":[{"name":"C.36.3.1","node_attrs":{"div":40,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36.3.1"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-26"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C6706T","C17822T","C18189T","G22992A","T24811C","T25729C","A29040G","C29632T"],"N":["K256R"],"ORF1b":["P1452L"],"ORF3a":["Y113H"],"S":["S477N"]},"labels":{"aa":"N: K256R; ORF1b: P1452L; ORF3a: Y113H; S: S477N","spike_mutations":"S477N"}}},{"name":"C.36.3","node_attrs":{"div":32,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.36.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.36.3"},"totalAminoacidDeletions":{"value":2},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-26"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000640","node_attrs":{"div":15,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"B.1.1.1"},"clade_membership":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9867C","T22917A","C28253T","A28271C"],"ORF1a":["L3201P"],"S":["L452Q"]},"labels":{"aa":"ORF1a: L3201P; S: L452Q","spike_mutations":"L452Q"}},"children":[{"name":"C.39","node_attrs":{"div":31,"clade_display":{"value":"20D"},"Nextclade_pango":{"value":"C.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20D"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.39"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":21},"clade_nextstrain":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2110T","C4763T","C6726T","C7113T","T7348G","C11345T","C14585T","C15194A","C21588T","G22131A","C22997T","T26038C","C26366T","C27128T","A28742G"],"E":["A41V"],"N":["I157V"],"ORF1a":["H1500Y","T2154I","T2283I","N2361K","L3694F"],"ORF1b":["A373V","A576D"],"ORF3a":["S216P"],"S":["P9L","R190K","P479S"]},"labels":{"aa":"E: A41V; N: I157V; ORF1a: H1500Y, T2154I, T2283I, N2361K, L3694F; ORF1b: A373V, A576D; ORF3a: S216P; S: P9L, R190K, P479S","spike_mutations":"P9L, R190K, P479S"}}},{"name":"NODE_0000641","node_attrs":{"div":28,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37"},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{"nuc":["C7124T","T7424G","C9857T","C10029T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21786T","C21789T","G22299-","A22300-","A22301-","G22302-","T22303-","T22304-","A22305-","T22306-","T22307-","T22308-","G22309-","A22310-","C22311-","T22312-","C22313-","C22314-","T22315-","G22316-","G22317-","T22318-","G22319-","T23031C","C24138A","C26894T","C28271T","C28311T","G28913T","C29311T"],"N":["P13L","G214C"],"ORF1a":["P2287S","F2387V","T3255I","S3675-","G3676-","F3677-"],"ORF9b":["P10S"],"S":["G75V","T76I","R246-","S247-","Y248-","L249-","T250-","P251-","G252-","D253N","F490S","T859N"]},"labels":{"aa":"N: P13L, G214C; ORF1a: P2287S, F2387V, T3255I, S3675-, G3676-, F3677-; ORF9b: P10S; S: G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N","clade":"Lambda","spike_mutations":"G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N"}},"children":[{"name":"C.37","node_attrs":{"div":28,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.37"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-23"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{}}},{"name":"C.37.1","node_attrs":{"div":32,"clade_display":{"value":"21G (Lambda)"},"Nextclade_pango":{"value":"C.37.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21G"},"clade_who":{"value":"Lambda"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.1.37.1"},"totalAminoacidDeletions":{"value":10},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":20},"clade_nextstrain":{"value":"21G"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C20806T","T25760C","A28877T","G28878C"],"ORF3a":["I123T"]},"labels":{"aa":"ORF3a: I123T"}}}]}]}]}]},{"name":"NODE_0000642","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8542699813842773}},"branch_attrs":{"mutations":{"nuc":["G25088T"],"S":["V1176F"]},"labels":{"aa":"S: V1176F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.28","node_attrs":{"div":8,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.8542699813842773}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.332","node_attrs":{"div":15,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.332"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.332"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":8},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.391775608062744}},"branch_attrs":{"mutations":{"nuc":["A1G","C442A","C6310T","G11417T","C12053T","T16944C","G26062C"],"ORF1a":["V3718F","L3930F"],"ORF3a":["G224R"]},"labels":{"aa":"ORF1a: V3718F, L3930F; ORF3a: G224R"}}},{"name":"P.3","node_attrs":{"div":26,"clade_display":{"value":"21E (Theta)"},"Nextclade_pango":{"value":"P.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21E"},"clade_who":{"value":"Theta"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.3"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-10"},"totalAminoacidSubstitutions":{"value":18},"clade_nextstrain":{"value":"21E"},"placement_prior":{"value":-4.444321632385254}},"branch_attrs":{"mutations":{"nuc":["A4926G","C7564A","T9867C","C11308A","C12049T","C12053T","C17074T","C17339T","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","A22356G","G23012A","A23063T","T23341C","C23604A","T24187A","G24836A","C24863T","A27897C","A28271-","C29724T"],"ORF1a":["D1554G","L3201P","D3681E","L3930F"],"ORF1b":["L1203F","A1291V"],"ORF8":["K2Q"],"S":["L141-","G142-","V143-","Y265C","E484K","N501Y","P681H","E1092K","H1101Y"]},"labels":{"aa":"ORF1a: D1554G, L3201P, D3681E, L3930F; ORF1b: L1203F, A1291V; ORF8: K2Q; S: L141-, G142-, V143-, Y265C, E484K, N501Y, P681H, E1092K, H1101Y","clade":"Theta","spike_mutations":"L141-, G142-, V143-, Y265C, E484K, N501Y, P681H, E1092K, H1101Y"}}},{"name":"P.7","node_attrs":{"div":21,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.7"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-30"},"totalAminoacidSubstitutions":{"value":13},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A1G","C1288T","C7124T","C7765T","G8027T","C9344T","G10870T","G11596T","C12053T","C17172T","C17676T","C25844T","C28311T"],"N":["P13L"],"ORF1a":["P2287S","V2588F","L3027F","Q3777H","L3930F"],"ORF3a":["T151I"],"ORF9b":["P10S"]},"labels":{"aa":"N: P13L; ORF1a: P2287S, V2588F, L3027F, Q3777H, L3930F; ORF3a: T151I; ORF9b: P10S"}}},{"name":"NODE_0000643","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.082197666168213}},"branch_attrs":{"mutations":{"nuc":["C12053T","C28253T"],"ORF1a":["L3930F"]},"labels":{"aa":"ORF1a: L3930F"}},"children":[{"name":"P.2","node_attrs":{"div":17,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.2"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":10},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.3414323329925537}},"branch_attrs":{"mutations":{"nuc":["C100T","T10667G","C11824T","G23012A","G28628T","G28975T","C29754T"],"N":["A119S","M234I"],"ORF1a":["L3468V"],"S":["E484K"]},"labels":{"aa":"N: A119S, M234I; ORF1a: L3468V; S: E484K","spike_mutations":"E484K"}}},{"name":"P.6","node_attrs":{"div":23,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.6"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-27"},"totalAminoacidSubstitutions":{"value":15},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C1077T","G2534T","C3736T","C7043T","C8980T","C10029T","A14113G","G21305A","G23587C","G23593T","C24382T","C25665T","G26172T"],"ORF1a":["P271L","V757F","P2260S","T3255I"],"ORF1b":["T216A","R2613H"],"ORF3a":["M260I"],"S":["Q675H","Q677H"]},"labels":{"aa":"ORF1a: P271L, V757F, P2260S, T3255I; ORF1b: T216A, R2613H; ORF3a: M260I; S: Q675H, Q677H","spike_mutations":"Q675H, Q677H"}}}]},{"name":"NODE_0000644","node_attrs":{"div":9,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-6.34883975982666}},"branch_attrs":{"mutations":{"nuc":["C11450A","A28271C"],"ORF1a":["Q3729K"]},"labels":{"aa":"ORF1a: Q3729K"}},"children":[{"name":"P.4","node_attrs":{"div":28,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.4"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-05-25"},"totalAminoacidSubstitutions":{"value":19},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A136G","G1811A","C3177T","C9693T","T9867C","C12008T","C12880T","A15932G","G18756T","C20436T","T22054G","C22079A","T22917G","C23673T","A23720G","G25540A","C28253T","C28932T"],"N":["A220V"],"ORF1a":["A516T","P971L","A3143V","L3201P","L3915F"],"ORF1b":["Y822C"],"ORF3a":["V50I"],"S":["N164K","Q173K","L452R","S704L","I720V"]},"labels":{"aa":"N: A220V; ORF1a: A516T, P971L, A3143V, L3201P, L3915F; ORF1b: Y822C; ORF3a: V50I; S: N164K, Q173K, L452R, S704L, I720V","spike_mutations":"N164K, Q173K, L452R, S704L, I720V"}}},{"name":"P.5","node_attrs":{"div":27,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"P.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.5"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-06-19"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5175T","C8950T","C9891T","T10264C","C11152T","C13275T","T14103C","C14571T","T21568A","C21602A","C21721T","C21846T","G23012C","A23064C","C24904T","C28271T","C28531T","G28917T"],"N":["G215V"],"ORF1a":["T1637I","A3209V","P4337L"],"ORF9b":["T83I"],"S":["F2L","Q14K","T95I","E484Q","N501T"]},"labels":{"aa":"N: G215V; ORF1a: T1637I, A3209V, P4337L; ORF9b: T83I; S: F2L, Q14K, T95I, E484Q, N501T","spike_mutations":"F2L, Q14K, T95I, E484Q, N501T"}}}]},{"name":"NODE_0000645","node_attrs":{"div":11,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.28"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.67503023147583}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21974T","A28877T","G28878C"],"ORF1a":["S3675-","G3676-","F3677-"],"S":["D138Y"]},"labels":{"aa":"ORF1a: S3675-, G3676-, F3677-; S: D138Y","spike_mutations":"D138Y"}},"children":[{"name":"B.1.1.528","node_attrs":{"div":25,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.528"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.528"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-19"},"totalAminoacidSubstitutions":{"value":16},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-4.921329021453857}},"branch_attrs":{"mutations":{"nuc":["A1072G","C1449T","C2094T","A3868T","G9526T","G9756A","G16853T","T22912G","C23604G","T25088G","T26767C","C27297T","A28911T","C29303T"],"M":["I82T"],"N":["N213I","P344S"],"ORF1a":["T395I","S610L","Q1201H","M3087I","R3164H"],"ORF1b":["G1129V"],"S":["N450K","P681R","F1176V"]},"labels":{"aa":"M: I82T; N: N213I, P344S; ORF1a: T395I, S610L, Q1201H, M3087I, R3164H; ORF1b: G1129V; S: N450K, P681R, F1176V","spike_mutations":"N450K, P681R, F1176V"}}},{"name":"NODE_0000646","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{"nuc":["T733C","C2749T","C3828T","A5648C","A6319G","A6613G","C12778T","C13860T","G17259T","C21614T","C21621A","C21638T","G22132T","A22812C","G23012A","A23063T","C23525T","C24642T","T26149C","G28167A","C28512G","T29834A"],"N":["P80R"],"ORF1a":["S1188L","K1795Q"],"ORF1b":["E1264D"],"ORF3a":["S253P"],"ORF8":["E92K"],"ORF9b":["Q77E"],"S":["L18F","T20N","P26S","R190S","K417T","E484K","N501Y","H655Y","T1027I"]},"labels":{"aa":"N: P80R; ORF1a: S1188L, K1795Q; ORF1b: E1264D; ORF3a: S253P; ORF8: E92K; ORF9b: Q77E; S: L18F, T20N, P26S, R190S, K417T, E484K, N501Y, H655Y, T1027I","clade":"Gamma","spike_mutations":"L18F, T20N, P26S, R190S, K417T, E484K, N501Y, H655Y, T1027I"}},"children":[{"name":"P.1","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-02-21"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{}}},{"name":"P.1.1","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-08"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.7353131771087646}},"branch_attrs":{"mutations":{"nuc":["T13851C"]}}},{"name":"P.1.11","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.11"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-18"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.509119987487793}},"branch_attrs":{"mutations":{"nuc":["C7945T","C23604G"],"S":["P681R"]},"labels":{"aa":"S: P681R","spike_mutations":"P681R"}}},{"name":"P.1.12","node_attrs":{"div":33,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.12"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-23"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8019158840179443}},"branch_attrs":{"mutations":{}}},{"name":"P.1.12.1","node_attrs":{"div":43,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.12.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-19"},"totalAminoacidSubstitutions":{"value":28},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["T3592C","T14769G","G20925A","A22298G","C22413T","T23599A","C25613T","C25844T","T28251G","C28253T"],"ORF3a":["S74F","T151I"],"ORF8":["F120V"],"S":["R246G","T284I","N679K"]},"labels":{"aa":"ORF3a: S74F, T151I; ORF8: F120V; S: R246G, T284I, N679K","spike_mutations":"R246G, T284I, N679K"}}},{"name":"P.1.14","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.14"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-2.8808484077453613}},"branch_attrs":{"mutations":{"nuc":["A1G","G9105A","C23380T"],"ORF1a":["S2947N"]},"labels":{"aa":"ORF1a: S2947N"}}},{"name":"P.1.15","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.15"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.483485460281372}},"branch_attrs":{"mutations":{"nuc":["A2596G","C18129T"]}}},{"name":"P.1.16","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.16"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.7957029342651367}},"branch_attrs":{"mutations":{"nuc":["A25746G"],"ORF3a":["I118M"]},"labels":{"aa":"ORF3a: I118M"}}},{"name":"P.1.4","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.4"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.011761665344238}},"branch_attrs":{"mutations":{"nuc":["T23599G"],"S":["N679K"]},"labels":{"aa":"S: N679K","spike_mutations":"N679K"}}},{"name":"P.1.6","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.6"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10615T","C15714T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}},{"name":"P.1.7.1","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.7.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-13"},"totalAminoacidSubstitutions":{"value":24},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T3049C","C10116T","C23604A"],"ORF1a":["T3284I"],"S":["P681H"]},"labels":{"aa":"ORF1a: T3284I; S: P681H","spike_mutations":"P681H"}}},{"name":"NODE_0000647","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.013174533843994}},"branch_attrs":{"mutations":{"nuc":["A1T","C1427T"],"ORF1a":["H388Y"]},"labels":{"aa":"ORF1a: H388Y"}},"children":[{"name":"P.1.10","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.10"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-12"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.013174533843994}},"branch_attrs":{"mutations":{}}},{"name":"P.1.10.1","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.10.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-12"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.112314701080322}},"branch_attrs":{"mutations":{"nuc":["C2841T","G4300T","C13329T","C26873T"],"ORF1a":["A859V","T4355I"]},"labels":{"aa":"ORF1a: A859V, T4355I"}}}]},{"name":"NODE_0000648","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A1T","C346T","C28603T"]}},"children":[{"name":"P.1.17.1","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.17.1"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A6704G","G19999T","C21707T"],"ORF1a":["N2147D"],"ORF1b":["V2178F"],"S":["H49Y"]},"labels":{"aa":"ORF1a: N2147D; ORF1b: V2178F; S: H49Y","spike_mutations":"H49Y"}}},{"name":"P.1.17","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.17"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-30"},"totalAminoacidSubstitutions":{"value":22},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000649","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["T592C","A4040G","C9891T"],"ORF1a":["I1259V","A3209V"]},"labels":{"aa":"ORF1a: I1259V, A3209V"}},"children":[{"name":"P.1.8","node_attrs":{"div":42,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.8"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-03"},"totalAminoacidSubstitutions":{"value":29},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A20055G","C22971A","C23604G","G25266T","C26039T","G27915T"],"ORF3a":["S216L"],"ORF8":["G8*"],"S":["T470N","P681R","C1235F"]},"labels":{"aa":"ORF3a: S216L; ORF8: G8*; S: T470N, P681R, C1235F","spike_mutations":"T470N, P681R, C1235F"}}},{"name":"P.1.9","node_attrs":{"div":39,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.9"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-08-10"},"totalAminoacidSubstitutions":{"value":26},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C6040T","C18647T","G23587C"],"ORF1b":["P1727L"],"S":["Q675H"]},"labels":{"aa":"ORF1b: P1727L; S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000650","node_attrs":{"div":34,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1"},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.685761451721191}},"branch_attrs":{"mutations":{"nuc":["C1912T"]}},"children":[{"name":"P.1.13","node_attrs":{"div":35,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.13"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-09-29"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.1822357177734375}},"branch_attrs":{"mutations":{"nuc":["G10610T"],"ORF1a":["V3449F"]},"labels":{"aa":"ORF1a: V3449F"}}},{"name":"P.1.2","node_attrs":{"div":38,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.2"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-04-26"},"totalAminoacidSubstitutions":{"value":25},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-4.205961227416992}},"branch_attrs":{"mutations":{"nuc":["A2550G","C5724T","G25855T","C28789T"],"ORF1a":["D762G","T1820I"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF1a: D762G, T1820I; ORF3a: D155Y"}}},{"name":"P.1.7","node_attrs":{"div":36,"clade_display":{"value":"20J (Gamma)"},"Nextclade_pango":{"value":"P.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20J"},"clade_who":{"value":"Gamma"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.28.1.7"},"totalAminoacidDeletions":{"value":3},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-07-22"},"totalAminoacidSubstitutions":{"value":23},"clade_nextstrain":{"value":"20J"},"placement_prior":{"value":-3.55728816986084}},"branch_attrs":{"mutations":{"nuc":["C16293T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}}]}]}]}]},{"name":"NODE_0000651","node_attrs":{"div":10,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1"},"clade_membership":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-3.7765681743621826}},"branch_attrs":{"mutations":{"nuc":["C10029T","C22995A","C23604A"],"ORF1a":["T3255I"],"S":["T478K","P681H"]},"labels":{"aa":"ORF1a: T3255I; S: T478K, P681H","spike_mutations":"T478K, P681H"}},"children":[{"name":"B.1.1.519","node_attrs":{"div":20,"clade_display":{"value":"20B"},"Nextclade_pango":{"value":"B.1.1.519"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"20B"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"B.1.1.519"},"totalAminoacidDeletions":{"value":0},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-03-15"},"totalAminoacidSubstitutions":{"value":11},"clade_nextstrain":{"value":"20B"},"placement_prior":{"value":-2.7773401737213135}},"branch_attrs":{"mutations":{"nuc":["C203T","C222T","C3140T","C10954T","A11117G","C12789T","T19839C","C21306T","A23756G","C29197T"],"ORF1a":["P959S","I3618V","T4175I"],"S":["T732A"]},"labels":{"aa":"ORF1a: P959S, I3618V, T4175I; S: T732A","spike_mutations":"T732A"}}},{"name":"21M","node_attrs":{"div":40,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-3.6954684257507324}},"branch_attrs":{"mutations":{"nuc":["C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","A23013C","A23040G","A23055G","A23063T","T23075C","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C26270T","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-"],"ORF1a":["P3395H","S3675-","G3676-"],"ORF1b":["I1566V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371F","S373P","S375F","K417N","N440K","G446S","S477N","E484A","Q493R","Q498R","N501Y","Y505H","H655Y","N679K","N764K","D796Y","Q954H","N969K"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-; ORF1a: P3395H, S3675-, G3676-; ORF1b: I1566V; ORF9b: P10S, E27-, N28-, A29-; S: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K","clade":"Omicron","spike_mutations":"A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"NODE_0000653","node_attrs":{"div":54,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.9919633865356445}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"ORF1a":["K856R","S2083-","L2084I","A2710T","L3674-","I3758V"],"S":["F371L","G496S","T547K","N856K","L981F"]},"labels":{"aa":"M: D3G; ORF1a: K856R, S2083-, L2084I, A2710T, L3674-, I3758V; S: F371L, G496S, T547K, N856K, L981F","clade":"21K","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}},"children":[{"name":"BA.1","node_attrs":{"div":54,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":46},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.9919633865356445}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.12","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.12"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7732186317443848}},"branch_attrs":{"mutations":{"nuc":["A5T","G22487C","C28315T"],"ORF9b":["A11V"],"S":["E309Q"]},"labels":{"aa":"ORF9b: A11V; S: E309Q","spike_mutations":"E309Q"}}},{"name":"BA.1.10","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.10"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.681899070739746}},"branch_attrs":{"mutations":{"nuc":["C21T","A17042G"],"ORF1b":["Y1192C"]},"labels":{"aa":"ORF1b: Y1192C"}}},{"name":"BA.1.19","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.19"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.5513505935668945}},"branch_attrs":{"mutations":{"nuc":["A1G","C21034T"],"ORF1b":["L2523F"]},"labels":{"aa":"ORF1b: L2523F"}}},{"name":"BA.1.18","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.18"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-29"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.3796181678771973}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"ORF1a":["T1822I"]},"labels":{"aa":"ORF1a: T1822I"}}},{"name":"BA.1.2","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.660147190093994}},"branch_attrs":{"mutations":{"nuc":["C7420T","C11669T"],"ORF1a":["R3802C"]},"labels":{"aa":"ORF1a: R3802C"}}},{"name":"BA.1.20","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.20"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.5852789878845215}},"branch_attrs":{"mutations":{"nuc":["C11950T","C28472T"],"N":["P67S"]},"labels":{"aa":"N: P67S"}}},{"name":"BA.1.22","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.22"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.776266574859619}},"branch_attrs":{"mutations":{"nuc":["C21T","G3182A","G5515T"],"ORF1a":["E973K"]},"labels":{"aa":"ORF1a: E973K"}}},{"name":"BA.1.23","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.23"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-07"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.952954292297363}},"branch_attrs":{"mutations":{"nuc":["G22599C","T22926G","A22935T","C23013T","C23625T"],"S":["R346T","L455W","K458M","A484V","A688V"]},"labels":{"aa":"S: R346T, L455W, K458M, A484V, A688V","spike_mutations":"R346T, L455W, K458M, A484V, A688V"}}},{"name":"BA.1.3","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.336390495300293}},"branch_attrs":{"mutations":{"nuc":["C21T","A3481G","C8645T"],"ORF1a":["H2794Y"]},"labels":{"aa":"ORF1a: H2794Y"}}},{"name":"BA.1.24","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.24"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.808385372161865}},"branch_attrs":{"mutations":{"nuc":["G22580A","G28378T"],"ORF9b":["R32L"],"S":["E340K"]},"labels":{"aa":"ORF9b: R32L; S: E340K","spike_mutations":"E340K"}}},{"name":"BA.1.6","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.6"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.269890308380127}},"branch_attrs":{"mutations":{"nuc":["C21T","C17639T"],"ORF1b":["S1391L"]},"labels":{"aa":"ORF1b: S1391L"}}},{"name":"BA.1.4","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.4"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.153940677642822}},"branch_attrs":{"mutations":{"nuc":["C21T","G23351A"],"S":["V597I"]},"labels":{"aa":"S: V597I","spike_mutations":"V597I"}}},{"name":"BA.1.5","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.5"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.170540809631348}},"branch_attrs":{"mutations":{"nuc":["C21T","C2091T","C24054T"],"ORF1a":["T609I"],"S":["A831V"]},"labels":{"aa":"ORF1a: T609I; S: A831V","spike_mutations":"A831V"}}},{"name":"BA.1.9","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.9"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.14980149269104}},"branch_attrs":{"mutations":{"nuc":["A1C","C21T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BA.1.7","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.7"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.598451852798462}},"branch_attrs":{"mutations":{"nuc":["C21T","C27686T"],"ORF7a":["S98F"]},"labels":{"aa":"ORF7a: S98F"}}},{"name":"BA.1.8","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.8"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.060263156890869}},"branch_attrs":{"mutations":{"nuc":["A1G","C11455T","C23987T","C29666T"],"S":["P809S"]},"labels":{"aa":"S: P809S","spike_mutations":"P809S"}}},{"name":"NODE_0000654","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{"nuc":["G1957T"],"ORF1a":["K564N"]},"labels":{"aa":"ORF1a: K564N"}},"children":[{"name":"BA.1.13","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.13"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.13.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.13.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.6200735569000244}},"branch_attrs":{"mutations":{"nuc":["A3779G","G19684T"],"ORF1a":["N1172D"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1a: N1172D; ORF1b: V2073L"}}}]},{"name":"NODE_0000655","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4473202228546143}},"branch_attrs":{"mutations":{"nuc":["G27762T"],"ORF7b":["E3*"]},"labels":{"aa":"ORF7b: E3*"}},"children":[{"name":"BA.1.21","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.21"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4473202228546143}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.21.1","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.21.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.21.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.046947002410889}},"branch_attrs":{"mutations":{"nuc":["T15685A"],"ORF1b":["L740M"]},"labels":{"aa":"ORF1b: L740M"}}}]},{"name":"NODE_0000656","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{"nuc":["A1C","C12786T"],"ORF1a":["T4174I"]},"labels":{"aa":"ORF1a: T4174I"}},"children":[{"name":"BA.1.14","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.14.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.468590497970581}},"branch_attrs":{"mutations":{"nuc":["C11109T"],"ORF1a":["A3615V"]},"labels":{"aa":"ORF1a: A3615V"}}},{"name":"BA.1.14.2","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.14.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.14.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.215561389923096}},"branch_attrs":{"mutations":{"nuc":["C1812T"],"ORF1a":["A516V"]},"labels":{"aa":"ORF1a: A516V"}}}]},{"name":"NODE_0000657","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{"nuc":["T3104C","C29632T"],"ORF1a":["Y947H"]},"labels":{"aa":"ORF1a: Y947H"}},"children":[{"name":"BA.1.16","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.16.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.663555145263672}},"branch_attrs":{"mutations":{"nuc":["G9758A","G25455A","T25556G"],"ORF1a":["V3165I"],"ORF3a":["V55G"]},"labels":{"aa":"ORF1a: V3165I; ORF3a: V55G"}}},{"name":"BA.1.16.2","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.16.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-5.067101955413818}},"branch_attrs":{"mutations":{"nuc":["C21T","T12436C","A28254G"],"ORF8":["I121V"]},"labels":{"aa":"ORF8: I121V"}}}]},{"name":"NODE_0000658","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{"nuc":["A1C","T10135C","C25708T","A29301G"],"N":["D343G"],"ORF3a":["L106F"]},"labels":{"aa":"N: D343G; ORF3a: L106F"}},"children":[{"name":"BA.1.15.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.538003921508789}},"branch_attrs":{"mutations":{"nuc":["A24803G"],"S":["I1081V"]},"labels":{"aa":"S: I1081V","spike_mutations":"I1081V"}}},{"name":"BA.1.15","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-16"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.15.3","node_attrs":{"div":61,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.2535817623138428}},"branch_attrs":{"mutations":{"nuc":["C21T","C3602T","C25886T"],"ORF1a":["H1113Y"],"ORF3a":["S165F"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: S165F"}}},{"name":"BA.1.15.2","node_attrs":{"div":60,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.15.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.754347085952759}},"branch_attrs":{"mutations":{"nuc":["G22520A","C23444A"],"S":["V320I","Q628K"]},"labels":{"aa":"S: V320I, Q628K","spike_mutations":"V320I, Q628K"}}}]},{"name":"NODE_0000659","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{"nuc":["A1C","G5924A"],"ORF1a":["V1887I"]},"labels":{"aa":"ORF1a: V1887I"}},"children":[{"name":"BA.1.17","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.17.1","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.100674629211426}},"branch_attrs":{"mutations":{"nuc":["C21T","C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}}},{"name":"NODE_0000660","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.2"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.335338592529297}},"branch_attrs":{"mutations":{"nuc":["C1G","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}},"children":[{"name":"BA.1.17.2","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.17.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.335338592529297}},"branch_attrs":{"mutations":{}}},{"name":"BD.1","node_attrs":{"div":61,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.17.2.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4503445625305176}},"branch_attrs":{"mutations":{"nuc":["C21T","C3241T","C23444A"],"S":["Q628K"]},"labels":{"aa":"S: Q628K","spike_mutations":"Q628K"}}}]}]},{"name":"NODE_0000661","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4241011142730713}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}},"children":[{"name":"BA.1.1","node_attrs":{"div":55,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-01-07"},"totalAminoacidSubstitutions":{"value":47},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.4241011142730713}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.1.3","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.3"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["C4582T","C23934T","A28416G"],"N":["N48S"],"ORF9b":["I45V"],"S":["T791I"]},"labels":{"aa":"N: N48S; ORF9b: I45V; S: T791I","spike_mutations":"T791I"}}},{"name":"BA.1.1.4","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.4"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.7377076148986816}},"branch_attrs":{"mutations":{"nuc":["C21T","G16744A","T25711C","C29754T"],"ORF1b":["G1093S"],"ORF3a":["Y107H"]},"labels":{"aa":"ORF1b: G1093S; ORF3a: Y107H"}}},{"name":"NODE_0000662","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.674670696258545}},"branch_attrs":{"mutations":{"nuc":["A1T","A16064G"],"ORF1b":["Q866R"]},"labels":{"aa":"ORF1b: Q866R"}},"children":[{"name":"BA.1.1.1","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.674670696258545}},"branch_attrs":{"mutations":{}}},{"name":"BC.1","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1.1"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.36091685295105}},"branch_attrs":{"mutations":{"nuc":["C5833T","A22259G"],"S":["I233V"]},"labels":{"aa":"S: I233V","spike_mutations":"I233V"}}},{"name":"BC.2","node_attrs":{"div":60,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BC.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.884258270263672}},"branch_attrs":{"mutations":{"nuc":["C21T","C13862T","G19348A"],"ORF1b":["T132I","V1961I"]},"labels":{"aa":"ORF1b: T132I, V1961I"}}}]},{"name":"NODE_0000663","node_attrs":{"div":56,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1"},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.3621480464935303}},"branch_attrs":{"mutations":{"nuc":["C2470T"]}},"children":[{"name":"BA.1.1.11","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.11"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.2315807342529297}},"branch_attrs":{"mutations":{"nuc":["G2354A"],"ORF1a":["G697R"]},"labels":{"aa":"ORF1a: G697R"}}},{"name":"BA.1.1.10","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.10"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4704771041870117}},"branch_attrs":{"mutations":{"nuc":["C21T","C12513T"],"ORF1a":["T4083M"]},"labels":{"aa":"ORF1a: T4083M"}}},{"name":"BA.1.1.12","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.12"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.3868720531463623}},"branch_attrs":{"mutations":{"nuc":["C21T","C2942A"],"ORF1a":["L893M"]},"labels":{"aa":"ORF1a: L893M"}}},{"name":"BA.1.1.13","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.13"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.139563798904419}},"branch_attrs":{"mutations":{"nuc":["C21T","C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"BA.1.1.14","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.14"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.8932130336761475}},"branch_attrs":{"mutations":{"nuc":["A14107G"],"ORF1b":["I214V"]},"labels":{"aa":"ORF1b: I214V"}}},{"name":"BA.1.1.16","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.16"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-1.8349038362503052}},"branch_attrs":{"mutations":{"nuc":["A1C","C21595T","C27509G"],"ORF7a":["T39R"]},"labels":{"aa":"ORF7a: T39R"}}},{"name":"BA.1.1.17","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.17"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.2085862159729}},"branch_attrs":{"mutations":{"nuc":["G1659T","C5183T"],"ORF1a":["G465V","P1640S"]},"labels":{"aa":"ORF1a: G465V, P1640S"}}},{"name":"BA.1.1.15","node_attrs":{"div":58,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.15"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.933518171310425}},"branch_attrs":{"mutations":{"nuc":["G13570A","G29755C"],"ORF1b":["G35S"]},"labels":{"aa":"ORF1b: G35S"}}},{"name":"BA.1.1.18","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.18"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.329127073287964}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"ORF1a":["A2554V"]},"labels":{"aa":"ORF1a: A2554V"}}},{"name":"BA.1.1.2","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.2"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-2.413982391357422}},"branch_attrs":{"mutations":{"nuc":["C10560G"],"ORF1a":["T3432S"]},"labels":{"aa":"ORF1a: T3432S"}}},{"name":"BA.1.1.5","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.5"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.915313482284546}},"branch_attrs":{"mutations":{"nuc":["C21T","A2589G","C26996T"],"ORF1a":["E775G"]},"labels":{"aa":"ORF1a: E775G"}}},{"name":"BA.1.1.7","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.7"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.486417531967163}},"branch_attrs":{"mutations":{"nuc":["C2453T"],"ORF1a":["L730F"]},"labels":{"aa":"ORF1a: L730F"}}},{"name":"BA.1.1.8","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.8"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.9190704822540283}},"branch_attrs":{"mutations":{"nuc":["C1766A"],"ORF1a":["Q501K"]},"labels":{"aa":"ORF1a: Q501K"}}},{"name":"BA.1.1.9","node_attrs":{"div":57,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.9"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-3.4197943210601807}},"branch_attrs":{"mutations":{"nuc":["C13421T"],"ORF1a":["L4386F"]},"labels":{"aa":"ORF1a: L4386F"}}},{"name":"BA.1.1.6","node_attrs":{"div":59,"clade_display":{"value":"21K (BA.1)"},"Nextclade_pango":{"value":"BA.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21K"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.1.1.6"},"totalAminoacidDeletions":{"value":16},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-23"},"totalAminoacidSubstitutions":{"value":48},"clade_nextstrain":{"value":"21K"},"placement_prior":{"value":-4.071193695068359}},"branch_attrs":{"mutations":{"nuc":["C21T","C5144T","C28757T"],"N":["P162S"]},"labels":{"aa":"N: P162S"}}}]}]}]},{"name":"internal_a01b","node_attrs":{"div":51,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.757229804992676}},"branch_attrs":{"mutations":{"nuc":["T670G","G4184A","C4321T","C9534T","G10447A","T11294-","T11295-","T11296-","C12880T","C15714T","G22775A","C26060T","C26858T","A29510C","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["S413R"],"ORF1a":["S135R","G1307S","T3090I","F3677-"],"ORF3a":["T223I"],"S":["D405N"]},"labels":{"aa":"N: S413R; ORF1a: S135R, G1307S, T3090I, F3677-; ORF3a: T223I; S: D405N","spike_mutations":"D405N"}},"children":[{"name":"internal_8b65","node_attrs":{"div":54,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3"},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"ORF1a":["A3657V"]},"labels":{"aa":"ORF1a: A3657V"}},"children":[{"name":"BA.3.1","node_attrs":{"div":57,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3.1"},"totalAminoacidDeletions":{"value":15},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-21"},"totalAminoacidSubstitutions":{"value":45},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3791A","C3792A","A22812C"],"ORF1a":["A1176N"],"S":["N417T"]},"labels":{"aa":"ORF1a: A1176N; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.3","node_attrs":{"div":54,"clade_display":{"value":"21M (Omicron)"},"Nextclade_pango":{"value":"BA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21M"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.3"},"totalAminoacidDeletions":{"value":15},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-14"},"totalAminoacidSubstitutions":{"value":44},"clade_nextstrain":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000666","node_attrs":{"div":70,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9307780265808105}},"branch_attrs":{"mutations":{"nuc":["C2790T","C9344T","A9424G","C10198T","C17410T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21762C","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","T21846C","-21987A","-21988T","-21989G","-21990T","-21991T","-21992T","-21993A","-21994T","-21995T","-22194A","-22195T","-22196T","T22200G","A22688G","A22786C","A22898G","C25000T","C25584T","G27382C","A27383T","T27384C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-"],"ORF1a":["T842I","L3027F"],"ORF1b":["R1315C","T2163I"],"ORF6":["D61L"],"S":["T19I","L24-","P25-","P26-","A27S","V67A","-69H","-70V","I95T","-142D","-143V","-144Y","D145Y","-211N","I212L","V213G","T376A","R408S","S446G"]},"labels":{"aa":"ORF1a: T842I, L3027F; ORF1b: R1315C, T2163I; ORF6: D61L; S: T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G","clade":"21L","spike_mutations":"T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G"}},"children":[{"name":"BA.2","node_attrs":{"div":70,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2021-12-07"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9307780265808105}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.16","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.223683834075928}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"ORF1a":["V84-","M85-"]},"labels":{"aa":"N: T296I; ORF1a: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.828702449798584}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"ORF1a":["T3150I"],"S":["W64L"]},"labels":{"aa":"ORF1a: T3150I; S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.19"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.502110004425049}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"ORF1a":["T333M"]},"labels":{"aa":"ORF1a: T333M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.87"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":129,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.87.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.8217399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.87.1"},"totalAminoacidDeletions":{"value":41},"immune_escape":{"value":"0.6657453429914796"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF1a":["Q15R","M85-","E93K","E1363D","S1372A","P1640L","A2344V","S2500F","T3258A","L3915F","K4176Q","P4211S"],"ORF1b":["G662S","L820F","Q1393K","L1966S"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF1a: Q15R, M85-, E93K, E1363D, S1372A, P1640L, A2344V, S2500F, T3258A, L3915F, K4176Q, P4211S; ORF1b: G662S, L820F, Q1393K, L1966S; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"NODE_0000668","node_attrs":{"div":71,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.4827568531036377}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"ORF1a":["L3201F"]},"labels":{"aa":"ORF1a: L3201F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.958770990371704}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"ORF1a":["T4175I"]},"labels":{"aa":"ORF1a: T4175I"}}},{"name":"BA.2.11","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"ORF1a":["S2519P"],"S":["L452R"]},"labels":{"aa":"ORF1a: S2519P; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0617406368255615}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9340405464172363}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.03172000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.24"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.01261797446067892"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.043281078338623}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.26"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5770962238311768}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"ORF1a":["L580F","T2825I"]},"labels":{"aa":"ORF1a: L580F, T2825I"}}},{"name":"BA.2.28","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.28"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.954390048980713}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF1a":["R2115S","T3032I"],"ORF3a":["D22G"]},"labels":{"aa":"ORF1a: R2115S, T3032I; ORF3a: D22G"}}},{"name":"BA.2.29","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.29"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.246047258377075}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"ORF1a":["A583T"]},"labels":{"aa":"ORF1a: A583T"}}},{"name":"BA.2.27","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.27"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9474263191223145}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"ORF1a":["M1083I"]},"labels":{"aa":"ORF1a: M1083I"}}},{"name":"BA.2.30","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.30"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.186139106750488}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF1a":["H1113Y"],"ORF3a":["E239D"]},"labels":{"aa":"ORF1a: H1113Y; ORF3a: E239D"}}},{"name":"BA.2.32","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.32"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.723714828491211}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.39","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.39"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"ORF1b":["E735D","V2237F","S2294G"],"S":["L858I"]},"labels":{"aa":"ORF1b: E735D, V2237F, S2294G; S: L858I","spike_mutations":"L858I"}}},{"name":"BA.2.4","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7227389812469482}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.41","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.41"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7298529148101807}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.42","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.42"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.43"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.411208152770996}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"ORF1a":["Q768R"],"S":["F371Y","E1202Q"]},"labels":{"aa":"ORF1a: Q768R; S: F371Y, E1202Q","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.46","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.46"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.78423547744751}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.48","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.48"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-01"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7899765968322754}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"ORF1a":["T1322I"],"S":["Y248S"]},"labels":{"aa":"ORF1a: T1322I; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.50"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.211312770843506}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.5","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5876340866088867}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"ORF1a":["P1018S"]},"labels":{"aa":"ORF1a: P1018S"}}},{"name":"BA.2.54","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.54"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.137404441833496}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.58","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.58"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.05063533782959}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.55","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.55"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.214793682098389}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.59","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.59"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.600702285766602}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.60","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.60"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.602741241455078}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"ORF1a":["T551S","P1497S"],"S":["V1129I","P1162S"]},"labels":{"aa":"ORF1a: T551S, P1497S; S: V1129I, P1162S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.61","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.61"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.497011184692383}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.62","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.62"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9947850704193115}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.63","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.63"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17851448059082}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"ORF1a":["S944L"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1a: S944L; ORF1b: R1736K"}}},{"name":"BA.2.65","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.65"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.8447577953338623}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.64","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.64"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5229573249816895}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"ORF1a":["L3667F"]},"labels":{"aa":"ORF1a: L3667F"}}},{"name":"BA.2.70","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.70"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.472323894500732}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"ORF1a":["I201V","K1655N","A2855T"]},"labels":{"aa":"ORF1a: I201V, K1655N, A2855T"}}},{"name":"BA.2.77","node_attrs":{"div":81,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9213199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.77"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3221048136122174"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.605336666107178}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF1a":["T3356I"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"]},"labels":{"aa":"E: L21F; M: S4F; ORF1a: T3356I; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.8","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-28"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.326139211654663}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":89,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.83"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.12534"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.83"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.22071783986880583"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF1a":["L2146F","T2174A","P3359S","T4311I"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"]},"labels":{"aa":"E: V58L; N: K65R; ORF1a: L2146F, T2174A, P3359S, T4311I; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.82","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.82"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.82"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.2169976234436035}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"ORF1a":["A4005T","T4311I"],"S":["I68T","R346T"]},"labels":{"aa":"ORF1a: A4005T, T4311I; S: I68T, R346T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.85","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.85"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.85"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.299220561981201}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000669","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"ORF1a":["T1543I","T4087I"],"S":["I1221T"]},"labels":{"aa":"ORF1a: T1543I, T4087I; S: I1221T","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000670","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.123861312866211}},"branch_attrs":{"mutations":{"nuc":["G670T"],"ORF1a":["R135S"]},"labels":{"aa":"ORF1a: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":49},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.123861312866211}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.23.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.136961936950684}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF1a":["S2535L"],"ORF9b":["N36Y"]},"labels":{"aa":"N: Q39L; ORF1a: S2535L; ORF9b: N36Y"}}}]},{"name":"internal_04a9","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"ORF1a":["D3936N"]},"labels":{"aa":"ORF1a: D3936N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.31.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.867143630981445}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000672","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.892359733581543}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.35","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.04096000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.35"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.569701671600342}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}},{"name":"BA.2.33","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.33"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.086283206939697}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P1213L"]},"labels":{"aa":"ORF1a: P1213L"}}}]},{"name":"internal_ad79","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.795884370803833}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"ORF1b":["Q2070H"]},"labels":{"aa":"ORF1b: Q2070H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.795884370803833}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.40.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.40.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.748093843460083}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000674","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9647769927978516}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.9647769927978516}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.56.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.56.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.696688175201416}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"NODE_0000675","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636352777481079}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"ORF1b":["S959P"]},"labels":{"aa":"ORF1b: S959P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.636352777481079}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.4","node_attrs":{"div":83,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.73328"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3166622371297313"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-09"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.095335006713867}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF1b":["G662S"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"]},"labels":{"aa":"ORF1b: G662S; ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"BA.2.10.3","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.07940673828125}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.2","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6844911575317383}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"internal_ffa6","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4720098972320557}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4720098972320557}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.09519000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.10.1.1"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.6181860283242497"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF1a":["K47R"],"ORF1b":["G662S"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"]},"labels":{"aa":"M: D3Y; N: T282I; ORF1a: K47R; ORF1b: G662S; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000677","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-1.6233294010162354}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-14"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6388018131256104}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.22"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2793378829956055}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"ORF1a":["Q3966H"],"S":["F186S"]},"labels":{"aa":"ORF1a: Q3966H; S: F186S","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.34"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.040848255157471}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.36"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.0697343349456787}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.45","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.30756000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.45"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-23"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6386520862579346}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.47","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.47"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.130117893218994}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"ORF1a":["L251F"],"S":["Y248H","S1261Y"]},"labels":{"aa":"ORF1a: L251F; S: Y248H, S1261Y","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.49"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-03"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7807652950286865}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.53","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.33552999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.53"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1085477953061414"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.51","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.51"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.694986581802368}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.52"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-05"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8800220489501953}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"ORF1a":["C655R"]},"labels":{"aa":"ORF1a: C655R"}}},{"name":"BA.2.6","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6629879474639893}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.69","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.69"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.939220905303955}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"ORF1b":["M454L"]},"labels":{"aa":"ORF1b: M454L"}}},{"name":"BA.2.7","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-03-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3562943935394287}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"ORF1a":["T2124I"]},"labels":{"aa":"ORF1a: T2124I"}}},{"name":"BA.2.71","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.71"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.660242795944214}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.72","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.72"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-12"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.616490125656128}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.80","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.80"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10838000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.80"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.31190394480802347"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6446309089660645}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"ORF1a":["N840H","R1404C"],"S":["R346T","K356T"]},"labels":{"aa":"ORF1a: N840H, R1404C; S: R346T, K356T","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.81"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.81"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.347172260284424}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"ORF1b":["I235T"],"S":["L452M"]},"labels":{"aa":"ORF1b: I235T; S: L452M","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"ORF1a":["I463V"]},"labels":{"aa":"ORF1a: I463V"}},"children":[{"name":"BA.2.25.1","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.99613094329834}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BA.2.25","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.25"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_8e5d","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.7391467094421387}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11284999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.44"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.021062466983009277"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-21"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.218840599060059}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.13.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.024046421051025}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000681","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1916520595550537}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1916520595550537}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":83,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-08"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"ORF1a":["K322R"],"S":["L452M"]},"labels":{"aa":"N: P67S, S412I; ORF1a: K322R; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.2","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.620241165161133}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"ORF1a":["T2007I"]},"labels":{"aa":"ORF1a: T2007I"}}},{"name":"BA.2.9.3","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3528671264648438}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.4","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.2389769554138184}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"ORF1a":["V1393A"]},"labels":{"aa":"ORF1a: V1393A"}}},{"name":"BA.2.9.6","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.5045342445373535}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"ORF1a":["V627F","P1640S"],"S":["L452M"]},"labels":{"aa":"ORF1a: V627F, P1640S; S: L452M","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":81,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.9.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.9.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF1a":["H1113Y"],"ORF1b":["Q1393R"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"]},"labels":{"aa":"ORF1a: H1113Y; ORF1b: Q1393R; ORF6: L61P; ORF9b: P51L; S: S730F","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000682","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF1a":["A2909V"],"ORF3a":["L140F"]},"labels":{"aa":"ORF1a: A2909V; ORF3a: L140F"}},"children":[{"name":"BA.2.3","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-02-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.10","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.098408222198486}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.1","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3.11","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7979328632354736}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"ORF1a":["T4354I"]},"labels":{"aa":"ORF1a: T4354I"}}},{"name":"BA.2.3.12","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"ORF1a":["T4087I"],"ORF1b":["L1681F"]},"labels":{"aa":"ORF1a: T4087I; ORF1b: L1681F"}}},{"name":"BA.2.3.15","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8729300498962402}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.13","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.3481757640838623}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"ORF1a":["L3338F"]},"labels":{"aa":"ORF1a: L3338F"}}},{"name":"BA.2.3.14","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.958418846130371}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"ORF1a":["D3222A"]},"labels":{"aa":"ORF1a: D3222A"}}},{"name":"BA.2.3.17","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8992514610290527}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"ORF1a":["K798N"],"ORF1b":["A88V"]},"labels":{"aa":"ORF1a: K798N; ORF1b: A88V"}}},{"name":"BA.2.3.19","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.19"},"totalAminoacidDeletions":{"value":6},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.70237398147583}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF1a":["C2239G"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF1a: C2239G; ORF9b: -27E, -28N, -29A; S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.3.18","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.462869644165039}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"ORF1b":["R1078C","I1435S"]},"labels":{"aa":"ORF1b: R1078C, I1435S"}}},{"name":"BA.2.3.4","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.00945520401001}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.5","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3020405769348145}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}}},{"name":"BA.2.3.7","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"ORF1a":["L631F"],"S":["K97E"]},"labels":{"aa":"N: M322I; ORF1a: L631F; S: K97E","spike_mutations":"K97E"}}},{"name":"BA.2.3.8","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"ORF1a":["T1572I","R1701S"]},"labels":{"aa":"ORF1a: T1572I, R1701S"}}},{"name":"BA.2.3.9","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8521335124969482}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9121456146240234}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":86,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9456899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.16.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.43687237373984505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"ORF1a":["E2089D","E3310Q","T4311I"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"]},"labels":{"aa":"M: S4F; ORF1a: E2089D, E3310Q, T4311I; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.601434707641602}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06758"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.828201770782471}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":87,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"DD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9683399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.21.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4733677107846063"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"ORF1a":["A3143V"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"]},"labels":{"aa":"ORF1a: A3143V; S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000685","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.17149543762207}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":85,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.37526000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.22"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.42289430257523936"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF1b":["P1452L"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"]},"labels":{"aa":"ORF1b: P1452L; ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0095014572143555}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000687","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF1a":["E10K","L122F","E726A","H1500Y","I1714V","K1795Q","S2103F","L3829F"],"ORF1b":["T984I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF1a: E10K, L122F, E726A, H1500Y, I1714V, K1795Q, S2103F, L3829F; ORF1b: T984I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1.1","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.6589000000000002"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.6029918987948071"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.66194"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.49181526572268314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-12"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.2","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BS.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.66821"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF6:34-62"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.4975483601650658"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000688","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF1a":["T727I","I1714T","M2169V","T2174I","T2648I","Q3922R"],"ORF1b":["T1404M"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"]},"labels":{"aa":"ORF1a: T727I, I1714T, M2169V, T2174I, T2648I, Q3922R; ORF1b: T1404M; ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":96,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.8190299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7593324873420084"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000689","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"ORF1b":["D146G"]},"labels":{"aa":"ORF1b: D146G"}},"children":[{"name":"CM.4","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.91683"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7016283989012374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G354C"],"ORF1a":["G30A"]},"labels":{"aa":"ORF1a: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":104,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9440299999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8143059671640498"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"ORF1a":["E750G","T2069I"],"S":["A348S"]},"labels":{"aa":"ORF1a: E750G, T2069I; S: A348S","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.2","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"CM.5.1","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}}]},{"name":"internal_fc49","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.99403"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7255583352017505"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000693","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1.2","node_attrs":{"div":103,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.4","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF1b":["N1790D"]},"labels":{"aa":"ORF1b: N1790D"}}},{"name":"NODE_0000694","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":104,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000695","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"ORF1b":["A975V"],"S":["K147N"]},"labels":{"aa":"ORF1b: A975V; S: K147N","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.8.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.17483999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9242014092872922"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":107,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"FV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.28625999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0761544902802131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-26"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_5873","node_attrs":{"div":97,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.3.20"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.12","node_attrs":{"div":102,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.11","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.35566999999999993"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0179803928276123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.3","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.29833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7566134796876517"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"ORF1a":["F3753V"],"S":["G485D"]},"labels":{"aa":"ORF1a: F3753V; S: G485D","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"ORF1a":["S2103F"]},"labels":{"aa":"ORF1a: S2103F"}},"children":[{"name":"CM.2","node_attrs":{"div":98,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"1.06344"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6802814026849654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":101,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000698","node_attrs":{"div":99,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"ORF1b":["N2133S"]},"labels":{"aa":"ORF1b: N2133S"}}},{"name":"NODE_0000699","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":100,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.24425000000000008"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8703968752086992"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-30"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":105,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"CM.7.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.9729599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9785485534494837"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"ORF1a":["L16F","A131T"],"ORF1b":["V345L"],"S":["R403K"]},"labels":{"aa":"ORF1a: L16F, A131T; ORF1b: V345L; S: R403K","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000700","node_attrs":{"div":72,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-2.1288509368896484}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.1123433113098145}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.21"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-19"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"ORF1a":["G1073R","D2833G"]},"labels":{"aa":"ORF1a: G1073R, D2833G"}}},{"name":"BA.2.37","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.37"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-03"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.100731134414673}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"ORF1a":["R1421K"]},"labels":{"aa":"ORF1a: R1421K"}}},{"name":"BA.2.57","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.57"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.165760517120361}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"ORF1a":["Y1920C"]},"labels":{"aa":"ORF1a: Y1920C"}}},{"name":"BA.2.66","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.66"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.677023410797119}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF1a":["N313K","G1152D"]},"labels":{"aa":"ORF1a: N313K, G1152D"}}},{"name":"BA.2.68","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.68"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.937255382537842}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"ORF1a":["G4287R"]},"labels":{"aa":"ORF1a: G4287R"}}},{"name":"BA.2.73","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.73"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0411696434021}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"ORF1a":["P2287S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P2287S; S: G257S","spike_mutations":"G257S"}}},{"name":"BA.2.74","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.21698000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.74"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.33134042675697756"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.8886804580688477}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.78","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.10556"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.78"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.664361953735352}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF1a":["K3353R"],"S":["L452M"]},"labels":{"aa":"ORF1a: K3353R; S: L452M","spike_mutations":"L452M"}}},{"name":"NODE_0000701","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.096076011657715}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.67"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-10"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"ORF1a":["D4317E"]},"labels":{"aa":"ORF1a: D4317E"}}},{"name":"NODE_0000702","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"ORF1b":["P976S"],"S":["Y248S","N450D"]},"labels":{"aa":"ORF1b: P976S; S: Y248S, N450D","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.79.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.058580000000000014"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.79.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.13308596942418072"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"ORF1a":["T2016I"],"ORF1b":["I1416V"]},"labels":{"aa":"ORF1a: T2016I; ORF1b: I1416V"}}}]}]},{"name":"NODE_0000703","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000704","node_attrs":{"div":76,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"ORF1b":["V2073L"]},"labels":{"aa":"ORF1b: V2073L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.11142000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.20519369277613297"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"ORF1a":["A3730T"],"S":["N185H"]},"labels":{"aa":"ORF1a: A3730T; S: N185H","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.76.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.18492"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.76.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.2640232066165751"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"ORF1a":["G1595S"],"S":["R357K"]},"labels":{"aa":"ORF1a: G1595S; S: R357K","spike_mutations":"R357K"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4447848796844482}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.23107"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.05832824607945421"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-06"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.4447848796844482}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":78,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.08445999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.07383293656037815"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":82,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0.11188000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.3.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.370455061085298"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-08"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.580877304077148}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"ORF1a":["F1214I","A3357G"],"S":["Y144-","G446S","L452Q"]},"labels":{"aa":"ORF1a: F1214I, A3357G; S: Y144-, G446S, L452Q","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000707","node_attrs":{"div":73,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.987913131713867}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":79,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.0862932205200195}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000708","node_attrs":{"div":75,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.91279411315918}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.2","node_attrs":{"div":80,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"ORF1a":["T1543I","N3725S","T4355I"],"S":["F157S"]},"labels":{"aa":"ORF1a: T1543I, N3725S, T4355I; S: F157S","spike_mutations":"F157S"}}},{"name":"BA.2.38.4","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.38.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07569000000000004"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.38.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3062371810866485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-4.449609756469727}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"-0"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.000030000450009085718"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":77,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"BA.2.12.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"21L"},"ace2_binding":{"value":"0.07350000000000005"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.062348652344665065"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"NODE_0000710","node_attrs":{"div":75,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0579044818878174}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":75,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0579044818878174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000711","node_attrs":{"div":77,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BA.2.12.1"},"clade_membership":{"value":"22C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-1.8292837142944336}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":80,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-14"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"ORF1a":["N2065D"],"ORF1b":["A914T"]},"labels":{"aa":"ORF1a: N2065D; ORF1b: A914T"}}},{"name":"BG.4","node_attrs":{"div":82,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"ORF1a":["I2278T"],"ORF1b":["L1504F"]},"labels":{"aa":"N: P162L; ORF1a: I2278T; ORF1b: L1504F"}}},{"name":"BG.3","node_attrs":{"div":79,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-4.567025661468506}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"ORF1a":["T2967A"]},"labels":{"aa":"ORF1a: T2967A"}}},{"name":"BG.5","node_attrs":{"div":79,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-28"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.8423187732696533}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"ORF1a":["D3972G"]},"labels":{"aa":"ORF1a: D3972G"}}},{"name":"BG.2","node_attrs":{"div":85,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-18"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF1a":["F3753V"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"]},"labels":{"aa":"N: T282I; ORF1a: F3753V; ORF7b: A15S; ORF8: Q18*; S: V1264L","spike_mutations":"V1264L"}}},{"name":"BG.7","node_attrs":{"div":84,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"ORF1a":["E726K","V1020A","F1632L","F2321L"]},"labels":{"aa":"ORF1a: E726K, V1020A, F1632L, F2321L"}}},{"name":"BG.6","node_attrs":{"div":80,"clade_display":{"value":"22C (BA.2.12.1)"},"Nextclade_pango":{"value":"BG.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22C"},"ace2_binding":{"value":"-0.1269299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.12.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.1617041364563271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"ORF1a":["V4266I"],"S":["E1202Q"]},"labels":{"aa":"ORF1a: V4266I; S: E1202Q","spike_mutations":"E1202Q"}}}]}]}]},{"name":"NODE_0000712","node_attrs":{"div":88,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"ORF1a":["S1221L","P1640S","N4060S"],"ORF1b":["G662S"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"]},"labels":{"aa":"E: T11A; ORF1a: S1221L, P1640S, N4060S; ORF1b: G662S; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":88,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.499692916870117}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BA.2.75.8","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04854"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"ORF1a":["V424A","R1170H"],"ORF1b":["K499R"],"S":["L452Q"]},"labels":{"aa":"ORF1a: V424A, R1170H; ORF1b: K499R; S: L452Q","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.544774532318115}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.9.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.514627933502197}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.4722700119018555}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.13451"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.39024840374521963"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.4722700119018555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000715","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.378986120223999}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"BR.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.7472099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.502370834350586}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b66e","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.24593"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5588825437629772"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"ORF1b":["T11A"],"S":["R346T"]},"labels":{"aa":"ORF1b: T11A; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0000717","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.9449499999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"BR.1.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.12575999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7451886007636047"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"ORF1b":["F2380L"],"S":["F486S"]},"labels":{"aa":"ORF1b: F2380L; S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000718","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.10514"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5013910005227346"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000719","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"ORF1a":["K4014R"],"S":["D574V"]},"labels":{"aa":"ORF1a: K4014R; S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BR.5.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"ORF1a":["K2029N"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1a: K2029N; ORF1b: T1522I"}}},{"name":"BR.5","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BR.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.03573"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.4.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5509033720256986"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_7b7e","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000721","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.210728645324707}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"ORF1a":["P2685S"]},"labels":{"aa":"ORF1a: P2685S"}}},{"name":"BL.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.16854"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF1b":["R1659I"],"ORF8":["L4F"],"S":["R346S"]},"labels":{"aa":"N: P368S; ORF1b: R1659I; ORF8: L4F; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000722","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590982437133789}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.590982437133789}},"branch_attrs":{"mutations":{}}},{"name":"BL.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"ORF1b":["H604Y"],"S":["K182E"]},"labels":{"aa":"ORF1b: H604Y; S: K182E","spike_mutations":"K182E"}}}]}]},{"name":"NODE_0000723","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1783857345581055}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.19193"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"ORF1b":["P2612L","R2613N"],"S":["F490L"]},"labels":{"aa":"ORF1b: P2612L, R2613N; S: F490L","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.3464399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5934256167649397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF1b":["R1430K"],"ORF7b":["S31P"],"S":["F490V"]},"labels":{"aa":"ORF1b: R1430K; ORF7b: S31P; S: F490V","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.56756"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6011952983295785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.1.2","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.543303966522217}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.6","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BL.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.11979"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5544855553668998"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF1a":["L1130F"],"S":["V445A"]},"labels":{"aa":"ORF1a: L1130F; S: V445A","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.681193828582764}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.681193828582764}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.1.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"ORF1a":["I257V","K2771R","A2912S"],"S":["N185D","H207R"]},"labels":{"aa":"ORF1a: I257V, K2771R, A2912S; S: N185D, H207R","spike_mutations":"N185D, H207R"}}}]},{"name":"internal_147e","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}},{"name":"BY.1.2.1","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BY.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["G101V","G4178S"],"S":["S494P"]},"labels":{"aa":"ORF1a: G101V, G4178S; S: S494P","spike_mutations":"S494P"}}}]},{"name":"internal_a555","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-19"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{}}},{"name":"CA.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.41646999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.716528415679932}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF1a":["S887F","S2024L"],"ORF3a":["G44R"],"S":["L452R","T604I"]},"labels":{"aa":"ORF1a: S887F, S2024L; ORF3a: G44R; S: L452R, T604I","spike_mutations":"L452R, T604I"}}},{"name":"CA.4","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"ORF1a":["G519S","E995D","S2389L"],"S":["S486P"]},"labels":{"aa":"ORF1a: G519S, E995D, S2389L; S: S486P","spike_mutations":"S486P"}}},{"name":"CA.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.6","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"ORF1a":["Y196H"]},"labels":{"aa":"ORF1a: Y196H"}}},{"name":"CA.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-24"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"ORF1a":["L3776I"],"S":["L452R"]},"labels":{"aa":"ORF1a: L3776I; S: L452R","spike_mutations":"L452R"}}},{"name":"internal_80b8","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CA.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.2371799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"NODE_0000730","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096992492675781}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.096992492675781}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78438138961792}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"ORF1a":["G392D"],"S":["F490S"]},"labels":{"aa":"ORF1a: G392D; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.6","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"ORF1a":["T3959A"]},"labels":{"aa":"ORF1a: T3959A"}}},{"name":"BN.5","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"ORF1a":["V2955M"]},"labels":{"aa":"ORF1a: V2955M"}}},{"name":"internal_40f9","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1724299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.38697362521288264"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.14197"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5511388309290768"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"internal_ece3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"ORF1a":["G392D","I567V"],"ORF1b":["T2537I"],"S":["N450D"]},"labels":{"aa":"ORF1a: G392D, I567V; ORF1b: T2537I; S: N450D","spike_mutations":"N450D"}},"children":[{"name":"BN.3.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.653690335850791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"ORF1a":["K1860R","L2778F"],"S":["F490S"]},"labels":{"aa":"ORF1a: K1860R, L2778F; S: F490S","spike_mutations":"F490S"}}},{"name":"BN.3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.11385"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5060716304521155"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000733","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"ORF1a":["L2146F"],"S":["L176F","D936H"]},"labels":{"aa":"ORF1a: L2146F; S: L176F, D936H","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.6","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"BN.1.8","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.5340599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9193315170816834"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.7","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"NODE_0000734","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.2021600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7420698342212109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000735","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"ORF1a":["S2103F"],"ORF1b":["G2436D"]},"labels":{"aa":"ORF1a: S2103F; ORF1b: G2436D"}},"children":[{"name":"BN.1.5","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000736","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.1331"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7470314258752732"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}},{"name":"BN.1.5.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.31233"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7815531080803261"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}}]}]},{"name":"NODE_0000737","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"totalAminoacidDeletions":{"value":13},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"ORF1a":["M85-"],"ORF1b":["V1149L","V1723M"]},"labels":{"aa":"ORF1a: M85-; ORF1b: V1149L, V1723M"}}},{"name":"BN.1.4.5","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"ORF1a":["T3287I"]},"labels":{"aa":"ORF1a: T3287I"}}},{"name":"NODE_0000738","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"ORF1a":["V3367I"],"ORF1b":["T284I"]},"labels":{"aa":"ORF1a: V3367I; ORF1b: T284I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":106,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF1a":["T4175I"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"]},"labels":{"aa":"ORF1a: T4175I; ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"ORF1b":["T2099I","K2557R"],"S":["Q1113K"]},"labels":{"aa":"M: T30I; ORF1b: T2099I, K2557R; S: Q1113K","spike_mutations":"Q1113K"}}},{"name":"BN.1.4.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"ORF1a":["P1096T"]},"labels":{"aa":"ORF1a: P1096T"}}}]}]},{"name":"NODE_0000739","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.136174201965332}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-28"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.220160484313965}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000740","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.5018532276153564}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.21326"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7326886306518271"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"ORF1b":["K1671I"],"S":["T470N"]},"labels":{"aa":"ORF1b: K1671I; S: T470N","spike_mutations":"T470N"}}},{"name":"BN.1.2.2","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.4","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"ORF1b":["D1746H"]},"labels":{"aa":"ORF1b: D1746H"}}},{"name":"BN.1.2.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.6","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"ORF1b":["A1326S"]},"labels":{"aa":"ORF1b: A1326S"}}},{"name":"BN.1.2.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.8","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000741","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.163092613220215}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"ORF1a":["Y1920H"],"ORF1b":["I1799S"]},"labels":{"aa":"ORF1a: Y1920H; ORF1b: I1799S"}}},{"name":"NODE_0000742","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1.2","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"ORF1b":["T1173A"],"S":["R190M"]},"labels":{"aa":"ORF1b: T1173A; S: R190M","spike_mutations":"R190M"}}},{"name":"FR.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.3","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF1a":["A206V"],"ORF1b":["A517V"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1a: A206V; ORF1b: A517V; ORF9b: G31R"}}},{"name":"FR.1.5","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"ORF1a":["V116M","S2242F","M4071T"]},"labels":{"aa":"ORF1a: V116M, S2242F, M4071T"}}},{"name":"NODE_0000743","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"ORF1a":["L293F"]},"labels":{"aa":"ORF1a: L293F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-31"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":107,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"FR.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF1a":["M3627I"],"ORF3a":["T229I"]},"labels":{"aa":"ORF1a: M3627I; ORF3a: T229I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.563670635223389}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.49798059463501}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.629613399505615}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"ORF1a":["F3486L"]},"labels":{"aa":"ORF1a: F3486L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8218002319335938}},"branch_attrs":{"mutations":{}}},{"name":"DS.2","node_attrs":{"div":102,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF1b":["H1550Y"],"S":["T572I"]},"labels":{"aa":"ORF1b: H1550Y; S: T572I","spike_mutations":"T572I"}}},{"name":"DS.1","node_attrs":{"div":101,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.16291"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0513083167390975"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}},{"name":"DS.3","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"DS.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"ORF1a":["H110Y"]},"labels":{"aa":"ORF1a: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-30"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"ORF1a":["Q1918R"]},"labels":{"aa":"ORF1a: Q1918R"}}},{"name":"BN.1.3.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"ORF1b":["L1783R"],"S":["V445A"]},"labels":{"aa":"ORF1b: L1783R; S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.12","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.9","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.1","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"EJ.3","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EJ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}}]},{"name":"internal_f14e","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.269749164581299}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":102,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"ORF1a":["T568I","V1211F"]},"labels":{"aa":"ORF1a: T568I, V1211F"}}},{"name":"BN.1.3.13","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.08629"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8610252871641654"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.6","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"ORF1a":["T1429I"]},"labels":{"aa":"ORF1a: T1429I"}}},{"name":"BN.1.3.5","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BN.1.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.25339"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7137312413663139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-02"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-3.8801074028015137}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}}]}]}]}]}]},{"name":"NODE_0000750","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"ORF1b":["V1706I"]},"labels":{"aa":"ORF1b: V1706I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":89,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BA.2.75.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"ORF1b":["P1652S"]},"labels":{"aa":"ORF1b: P1652S"}}},{"name":"BM.6","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"ORF1a":["D2801G"],"S":["G75V","L455S"]},"labels":{"aa":"N: L113I; ORF1a: D2801G; S: G75V, L455S","spike_mutations":"G75V, L455S"}}},{"name":"BM.5","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.15852"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3112478426618121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.03087854385376}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000751","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2.2","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.26994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.5272935807019111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"ORF1a":["L1853F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L1853F; S: L455S","spike_mutations":"L455S"}}},{"name":"BM.2","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.28689"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.43632774842967204"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000752","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.81858"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}},{"name":"BM.2.3","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.78817"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-30"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-03"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000755","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"ORF1a":["R124C","S376L","F2864L"],"S":["T883I","S939F","P1079T"]},"labels":{"aa":"ORF1a: R124C, S376L, F2864L; S: T883I, S939F, P1079T","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.992039203643799}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.43724"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.26723051071167}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":95,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000758","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"ORF1a":["T1581A"]},"labels":{"aa":"ORF1a: T1581A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.87567"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9457248359372292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-14"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"ORF1a":["L2609F"]},"labels":{"aa":"ORF1a: L2609F"}}}]},{"name":"NODE_0000759","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3.1","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"ORF1a":["G3578S"],"S":["R214S"]},"labels":{"aa":"ORF1a: G3578S; S: R214S","spike_mutations":"R214S"}}},{"name":"CJ.1.3","node_attrs":{"div":98,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-07"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.2","node_attrs":{"div":100,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CJ.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.04277"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7836579797060339"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"ORF1a":["F3785L"],"S":["D936H"]},"labels":{"aa":"ORF1a: F3785L; S: D936H","spike_mutations":"D936H"}}}]}]}]},{"name":"NODE_0000760","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000761","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"]}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.1","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42674000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.752146957006636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"ORF1a":["V1550A"],"S":["L452R"]},"labels":{"aa":"ORF1a: V1550A; S: L452R","spike_mutations":"L452R"}}},{"name":"CV.2","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-06"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"ORF1a":["G514E"],"ORF1b":["Y1147C"],"S":["S486P"]},"labels":{"aa":"ORF1a: G514E; ORF1b: Y1147C; S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000762","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"ORF1a":["S216Y","D629A"],"S":["K356T","T572I"]},"labels":{"aa":"ORF1a: S216Y, D629A; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000763","node_attrs":{"div":99,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.1.1.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":104,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.46466000000000013"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.760602270328532"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000764","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"ORF1b":["V2406I"],"S":["L452R"]},"labels":{"aa":"ORF1b: V2406I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":105,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000765","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF1a":["P4120S"],"ORF8":["Q18H"]},"labels":{"aa":"ORF1a: P4120S; ORF8: Q18H"}},"children":[{"name":"EP.1.1","node_attrs":{"div":109,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":118,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"EP.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.42369999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.8912656658423938"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-26"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"ORF1a":["Q1198K"]},"labels":{"aa":"ORF1a: Q1198K"}},"children":[{"name":"BM.4","node_attrs":{"div":90,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.17547"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.23333202257863933"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":91,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.35628"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.3762887593808791"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":92,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-4.506659507751465}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.4677"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000769","node_attrs":{"div":93,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"BM.4.1.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.852804660797119}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"ORF1b":["Q2425R"]},"labels":{"aa":"ORF1b: Q2425R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":97,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.0219999999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6604462442172514"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":96,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"1.07323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.6094925309137131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"clade_membership":{"value":"22D"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":94,"clade_display":{"value":"22D (BA.2.75)"},"Nextclade_pango":{"value":"CH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22D"},"ace2_binding":{"value":"0.36891999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.7685109779549473"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000772","node_attrs":{"div":95,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":95,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"ORF1a":["S538L"]},"labels":{"aa":"ORF1a: S538L"}}},{"name":"CH.1.1.7","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"ORF1a":["F143C"]},"labels":{"aa":"ORF1a: F143C"}}},{"name":"NODE_0000773","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"ORF1a":["M584V","A1074V"],"S":["K187T"]},"labels":{"aa":"N: A155V; ORF1a: M584V, A1074V; S: K187T","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"23C"},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"ace2_binding":{"value":"0.08511000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":1},"frameShifts":{"value":"ORF7a:59-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.9441222497200389"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["C58-"],"S":["N481Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: C58-; S: N481Y","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000774","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000775","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"ORF1a":["H1545Q"],"ORF1b":["V1520L"],"S":["S486P"]},"labels":{"aa":"ORF1a: H1545Q; ORF1b: V1520L; S: S486P","spike_mutations":"S486P"}},"children":[{"name":"GQ.1.1","node_attrs":{"div":107,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF1a":["G82-","H83-","V84-","M85V","I3255T"],"ORF1b":["T239I"],"ORF7a":["H47N"],"S":["G213E"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, I3255T; ORF1b: T239I; ORF7a: H47N; S: G213E","spike_mutations":"G213E"}}},{"name":"GQ.1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.9334899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000776","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.513967514038086}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"ORF1a":["G442S"]},"labels":{"aa":"ORF1a: G442S"}}},{"name":"CH.1.1.15","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"ORF1a":["Y1846C","G2294S"],"S":["T883I"]},"labels":{"aa":"ORF1a: Y1846C, G2294S; S: T883I","spike_mutations":"T883I"}}},{"name":"CH.1.1.25","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"ORF1a":["S330L","P4197S"]},"labels":{"aa":"ORF1a: S330L, P4197S"}}},{"name":"CH.1.1.24","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.29","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"ORF1a":["P371S"],"S":["Q613H"]},"labels":{"aa":"ORF1a: P371S; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-07"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000777","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"ORF1a":["A427V"],"ORF1b":["K2140R"],"S":["N185D"]},"labels":{"aa":"ORF1a: A427V; ORF1b: K2140R; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.010194301605225}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"internal_ddb1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"ORF1a":["R24C"],"S":["Q613H"]},"labels":{"aa":"ORF1a: R24C; S: Q613H","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"ORF1a":["E377K"]},"labels":{"aa":"ORF1a: E377K"}},"children":[{"name":"DV.3","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"ORF1b":["V839I"]},"labels":{"aa":"ORF1b: V839I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-06"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.93373441696167}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":73},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"ORF1b":["T1522I"]},"labels":{"aa":"ORF1b: T1522I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"ORF1a":["A3548V"],"S":["L858I"]},"labels":{"aa":"ORF1a: A3548V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF1b":["A520V"],"ORF3a":["A72T"]},"labels":{"aa":"ORF1b: A520V; ORF3a: A72T"}},"children":[{"name":"DV.7.2","node_attrs":{"div":109,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-25"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000785","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-26"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"ORF1a":["D2582G","P3952S"],"S":["T961M"]},"labels":{"aa":"ORF1a: D2582G, P3952S; S: T961M","spike_mutations":"T961M"}}},{"name":"NODE_0000786","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.7","node_attrs":{"div":117,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"ORF1a":["T666N","H1108Y"],"S":["V90I"]},"labels":{"aa":"ORF1a: T666N, H1108Y; S: V90I","spike_mutations":"V90I"}}},{"name":"DV.7.1.6","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}}]},{"name":"internal_38689e19","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF1a":["A4162V"]},"labels":{"aa":"ORF1a: A4162V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":114,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"ORF1a":["S2246L"]},"labels":{"aa":"ORF1a: S2246L"}},"children":[{"name":"JV.1","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":81},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}},{"name":"JV.2","node_attrs":{"div":118,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"ORF1a":["A690V"],"S":["V772I"]},"labels":{"aa":"ORF1a: A690V; S: V772I","spike_mutations":"V772I"}}}]}]},{"name":"NODE_0000789","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":119,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"KG.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.9432199999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.236487472982447"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"ORF1a":["S100N","D1697E"],"S":["H49Y","A264D","G485R"]},"labels":{"aa":"ORF1a: S100N, D1697E; S: H49Y, A264D, G485R","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000790","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-11"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.3","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.62047004699707}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-15"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"DV.7.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"-1.05117"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.1630613054040446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-17"},"totalAminoacidSubstitutions":{"value":80},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000791","node_attrs":{"div":96,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF1b":["V1092F"],"ORF7b":["I26S"]},"labels":{"aa":"ORF1b: V1092F; ORF7b: I26S"}}},{"name":"CH.1.1.32","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF1a":["E974A"],"ORF9b":["Q77K"],"S":["L858I"]},"labels":{"aa":"N: P80Q; ORF1a: E974A; ORF9b: Q77K; S: L858I","spike_mutations":"L858I"}}},{"name":"NODE_0000792","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000793","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"ORF1a":["A1176T"]},"labels":{"aa":"ORF1a: A1176T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.2560625076293945}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.3","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}},{"name":"GP.2","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"GP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}}]},{"name":"NODE_0000794","node_attrs":{"div":97,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-3.320462465286255}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":104,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF1a":["A698T"],"S":["T299I","R403K","D1165G"]},"labels":{"aa":"ORF1a: A698T; S: T299I, R403K, D1165G","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.22","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF1a":["A2850V"],"ORF6":["K23I"],"S":["K679R"]},"labels":{"aa":"ORF1a: A2850V; ORF6: K23I; S: K679R","spike_mutations":"K679R"}}},{"name":"CH.1.1.23","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.9155097007751465}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.30","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"ORF1a":["Y2968H"]},"labels":{"aa":"ORF1a: Y2968H"}}},{"name":"CH.1.1.5","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-13"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.6","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"ORF1a":["K338R","P1786L"],"S":["T732I"]},"labels":{"aa":"ORF1a: K338R, P1786L; S: T732I","spike_mutations":"T732I"}}},{"name":"CH.1.1.8","node_attrs":{"div":99,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000795","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"ORF1a":["G82-","H83-","V84-","M85V","A486V"],"S":["L858I"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V, A486V; S: L858I","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":71},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.7296142578125}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":101,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-21"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"ORF1a":["Q3966R"]},"labels":{"aa":"ORF1a: Q3966R"}}}]},{"name":"NODE_0000796","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":68},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":100,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-29"},"totalAminoacidSubstitutions":{"value":70},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF1a":["A1204V"],"ORF6":["I26V"]},"labels":{"aa":"ORF1a: A1204V; ORF6: I26V"}}}]},{"name":"NODE_0000797","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"ORF1a":["N593S","P1497S","T2791I"],"ORF1b":["D1024N"]},"labels":{"aa":"ORF1a: N593S, P1497S, T2791I; ORF1b: D1024N"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000798","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","G2265D"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, G2265D; ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1.1","node_attrs":{"div":115,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-01"},"totalAminoacidSubstitutions":{"value":79},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF1a":["T1542I"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"]},"labels":{"aa":"ORF1a: T1542I; ORF3a: P274S; ORF6: L61H; S: G1219V","spike_mutations":"G1219V"}}},{"name":"JP.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"1.05667"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:62-122"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"totalAminoacidDeletions":{"value":34},"immune_escape":{"value":"1.0267165804076408"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":98,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"CH.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-20"},"totalAminoacidSubstitutions":{"value":69},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"internal_7d467e42","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"ORF1a":["L3829F"],"S":["D215G","Q613H"]},"labels":{"aa":"ORF1a: L3829F; S: D215G, Q613H","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":102,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-31"},"totalAminoacidSubstitutions":{"value":72},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"ORF1a":["L384F","R550H"]},"labels":{"aa":"ORF1a: L384F, R550H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":105,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-22"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.2","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":78},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF1a":["D139N","R226K","Q556K"],"ORF3a":["T64N"]},"labels":{"aa":"ORF1a: D139N, R226K, Q556K; ORF3a: T64N"}}},{"name":"FK.1.2.1","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"ORF1a":["T891I"]},"labels":{"aa":"ORF1a: T891I"}}}]},{"name":"internal_d1673169","node_attrs":{"div":103,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"ORF1a":["M3752I"],"S":["G181A"]},"labels":{"aa":"ORF1a: M3752I; S: G181A","spike_mutations":"G181A"}}},{"name":"FK.1.4","node_attrs":{"div":106,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000804","node_attrs":{"div":107,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF1b":["L2580I"],"ORF9b":["G31R"]},"labels":{"aa":"N: -31E, G34-; ORF1b: L2580I; ORF9b: G31R"}},"children":[{"name":"FK.1.5","node_attrs":{"div":109,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":74},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"internal_5faff5ea","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"ORF1a":["A1060T"]},"labels":{"aa":"ORF1a: A1060T"}},"children":[{"name":"FK.1.1","node_attrs":{"div":108,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-13"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}},{"name":"FK.1.1.1","node_attrs":{"div":112,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.16085999999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9815994835819151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-24"},"totalAminoacidSubstitutions":{"value":77},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"ORF1a":["A1352V"],"S":["V445A"]},"labels":{"aa":"ORF1a: A1352V; S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_5be7761b","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["T241-","C3874T","G18984A","G26888A"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":110,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-24"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.260318756103516}},"branch_attrs":{"mutations":{"nuc":["-241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":111,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000807","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"clade_membership":{"value":"23C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":113,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"FK.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":75},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":116,"clade_display":{"value":"23C (CH.1.1)"},"Nextclade_pango":{"value":"JL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23C"},"ace2_binding":{"value":"0.32796"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"totalAminoacidDeletions":{"value":12},"immune_escape":{"value":"0.9092912257894785"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-04"},"totalAminoacidSubstitutions":{"value":76},"clade_nextstrain":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000808","node_attrs":{"div":118,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"ORF1a":["A211D","V1056L","N2526S","A2710T","V3593F","T4175I"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; ORF1a: A211D, V1056L, N2526S, A2710T, V3593F, T4175I; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"LV.2","node_attrs":{"div":132,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"ORF1a":["E148G","W630C","G1069R","G3546D"],"ORF1b":["A520V"],"S":["R346T","L455S","F456L"]},"labels":{"aa":"ORF1a: E148G, W630C, G1069R, G3546D; ORF1b: A520V; S: R346T, L455S, F456L","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000809","node_attrs":{"div":120,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.68471097946167}},"branch_attrs":{"mutations":{"nuc":["C21T","T13339C"]}},"children":[{"name":"BA.2.86","node_attrs":{"div":120,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-17"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.68471097946167}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":121,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.4","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"ORF1a":["V3892A"],"S":["A222V"]},"labels":{"aa":"ORF1a: V3892A; S: A222V","spike_mutations":"A222V"}}},{"name":"BA.2.86.5","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"NODE_0000810","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}},"children":[{"name":"BA.2.86.6","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"LV.1","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"LV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G14347A"],"ORF1b":["D294N"]},"labels":{"aa":"ORF1b: D294N"}}}]},{"name":"NODE_0000811","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"ORF1b":["Y1344H"]},"labels":{"aa":"ORF1b: Y1344H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-13"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000812","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"MP.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.12555999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.6738025507980547"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000813","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":82},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.761799335479736}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000814","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.15919"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.450453001635465"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-05"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000815","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"ORF1a":["L3711F"],"S":["L455S"]},"labels":{"aa":"ORF1a: L3711F; S: L455S","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-20"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":137,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"ORF1b":["Q813H","L1504F"],"S":["T572I"]},"labels":{"aa":"ORF1b: Q813H, L1504F; S: T572I","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":134,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JQ.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF1a":["T265I"],"ORF3a":["I123T"],"S":["F456L"]},"labels":{"aa":"ORF1a: T265I; ORF3a: I123T; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000816","node_attrs":{"div":122,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.804112911224365}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"ORF1a":["K1973R"]},"labels":{"aa":"ORF1a: K1973R"}},"children":[{"name":"JN.4","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.519156455993652}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000817","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":123,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-05"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"ORF1a":["A498G"],"S":["F456V"]},"labels":{"aa":"ORF1a: A498G; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.16","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.15","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.15"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.17","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.14","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.19","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.19"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.18","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.6","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.700375556945801}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.8","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"NODE_0000818","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11.1","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.11","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.07535457611084}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000819","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":83},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-06"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000820","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","C6525T","C29171T"],"N":["H300Y"],"ORF1a":["P892S","T2087I"]},"labels":{"aa":"N: H300Y; ORF1a: P892S, T2087I"}},"children":[{"name":"JN.3.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.2850199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.4889947175626428"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.3.2","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-16"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000821","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-14"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":132,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.6465599999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000822","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"ORF1a":["T2087I"]},"labels":{"aa":"ORF1a: T2087I"}},"children":[{"name":"JN.3","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.1","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-17"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3.3","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}}]},{"name":"internal_59b29264","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"ORF1a":["Y621C"]},"labels":{"aa":"ORF1a: Y621C"}},"children":[{"name":"JN.2","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-10-12"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-3.936847686767578}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.4","node_attrs":{"div":127,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"JN.2.5","node_attrs":{"div":126,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":85},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"NODE_0000824","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"ORF1a":["L3644F"],"S":["T572I"]},"labels":{"aa":"N: G25C; ORF1a: L3644F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":128,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"1.04777"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.282711495408898"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":130,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.2.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"-0.3844699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.3875211680198292"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-26"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"ORF1a":["G82-","H83-","V84-","M85V"],"S":["N487D"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85V; S: N487D","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000825","node_attrs":{"div":124,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"BA.2.86.1"},"clade_membership":{"value":"23I"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":125,"clade_display":{"value":"23I (BA.2.86)"},"Nextclade_pango":{"value":"JN.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"23I"},"ace2_binding":{"value":"0.32843999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.45439241518997"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-21"},"totalAminoacidSubstitutions":{"value":84},"clade_nextstrain":{"value":"23I"},"placement_prior":{"value":-4.503751754760742}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000826","node_attrs":{"div":128,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7886734008789062}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF1a":["R3821K"],"ORF7b":["F19L"],"S":["L455S"]},"labels":{"aa":"ORF1a: R3821K; ORF7b: F19L; S: L455S","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":128,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-29"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.7886734008789062}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.413212776184082}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.26806999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-21"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2179718017578125}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.394120693206787}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9045636653900146}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.20","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063994884490967}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.21","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.875786304473877}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.22","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.6742007732391357}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"ORF1a":["S505F"]},"labels":{"aa":"ORF1a: S505F"}}},{"name":"JN.1.3","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-20"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4943132400512695}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.498900413513184}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.407996654510498}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.0337066650390625}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.46","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.232485294342041}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}}},{"name":"JN.1.45","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.2978410720825195}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.5","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.8044490814208984}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"ORF1b":["V1271T"]},"labels":{"aa":"ORF1b: V1271T"}}},{"name":"JN.1.52","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.117572784423828}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"ORF1a":["K3353R"]},"labels":{"aa":"ORF1a: K3353R"}}},{"name":"JN.1.60","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.344854354858398}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.61","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.93036"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.496607246855186"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4297661781311035}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.67","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.5563645362854}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}}},{"name":"JN.1.66","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF1a":["L2146F","T2283I"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"]},"labels":{"aa":"ORF1a: L2146F, T2283I; ORF3a: L106F; S: H445P, F456L, T1117I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086506843566895}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"ORF1b":["T2488M"],"S":["M1229I"]},"labels":{"aa":"ORF1b: T2488M; S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1086506843566895}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.2.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.971957206726074}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240969657897949}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"ORF1a":["A307V","P2144L"],"S":["K444R","Y453F"]},"labels":{"aa":"ORF1a: A307V, P2144L; S: K444R, Y453F","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"ORF1a":["L1130F"],"S":["N137K","V1264L"]},"labels":{"aa":"ORF1a: L1130F; S: N137K, V1264L","spike_mutations":"N137K, V1264L"}}},{"name":"JN.1.23","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"2.21099"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.535410297587269"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-20"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.240969657897949}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_f571b810","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013700485229492}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.323051452636719}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.24","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.013700485229492}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.16291618347168}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.16291618347168}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.32.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.32.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.261717796325684}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}}]},{"name":"internal_613b5275","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.847394943237305}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"ORF1b":["R1736K"]},"labels":{"aa":"ORF1b: R1736K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.847394943237305}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3922882080078125}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.3922882080078125}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.43.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.052920818328857}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741697788238525}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.846282005310059}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.44","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.741697788238525}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.501391887664795}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.501391887664795}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.54.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.54.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.05681999999999991"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.532734695870142"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"ORF1a":["D2060N","M2096T"],"S":["V407I","F456L"]},"labels":{"aa":"ORF1a: D2060N, M2096T; S: V407I, F456L","spike_mutations":"V407I, F456L"}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9070000648498535}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9070000648498535}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.56.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.56.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.7602899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5395016697354735"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-31"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"ORF1a":["T1638I"],"S":["G181R","R346T","F456V","K484E"]},"labels":{"aa":"ORF1a: T1638I; S: G181R, R346T, F456V, K484E","spike_mutations":"G181R, R346T, F456V, K484E"}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803360939025879}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"ORF1a":["A1204S"]},"labels":{"aa":"ORF1a: A1204S"}},"children":[{"name":"JN.1.59.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":8.507},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"ORF1a":["I841V"],"S":["S31-","R190S","R346T"]},"labels":{"aa":"ORF1a: I841V; S: S31-, R190S, R346T","spike_mutations":"S31-, R190S, R346T"}}},{"name":"JN.1.59","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.803360939025879}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235310077667236}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.235310077667236}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4939866065979}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000838","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1673784255981445}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"ORF1b":["K82R"]},"labels":{"aa":"ORF1b: K82R"}},"children":[{"name":"JN.1.63.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.744482040405273}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"ORF1a":["D1513E","A2529S"]},"labels":{"aa":"ORF1a: D1513E, A2529S"}}},{"name":"JN.1.63","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1673784255981445}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_4e516d94","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.049008369445801}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.049008369445801}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.251441478729248}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.251441478729248}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"ORF1b":["T239I"],"S":["F456L"]},"labels":{"aa":"ORF1b: T239I; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395014762878418}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"ORF1a":["T3224A"]},"labels":{"aa":"ORF1a: T3224A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.395014762878418}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.29.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.341401100158691}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF1a":["E2070K"],"ORF8":["I121-"],"S":["S31P","R346T"]},"labels":{"aa":"ORF1a: E2070K; ORF8: I121-; S: S31P, R346T","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.455239772796631}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332273483276367}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.332273483276367}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.36.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.063151836395264}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005981922149658}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.993703842163086}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"JN.1.47.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"ORF1a":["H374Y"],"S":["T572I","R683Q"]},"labels":{"aa":"ORF1a: H374Y; S: T572I, R683Q","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005981922149658}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.405921936035156}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.405921936035156}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082502841949463}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.51.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.082502841949463}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.514431953430176}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"ORF1a":["K399R"]},"labels":{"aa":"ORF1a: K399R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.514431953430176}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.825034141540527}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"ORF1a":["T1017I"]},"labels":{"aa":"ORF1a: T1017I"}}},{"name":"JN.1.55.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.55.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.631012916564941}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"ORF1b":["P2321H"]},"labels":{"aa":"ORF1b: P2321H"}}}]}]},{"name":"NODE_0000850","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.62","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-08"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","G23604A"],"S":["V62F","R681H"]},"labels":{"aa":"S: V62F, R681H","spike_mutations":"V62F, R681H"}}},{"name":"NODE_0000851","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{"nuc":["G4162A","G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.67.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1867594718933105}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MZ.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9003684520721436}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9003684520721436}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.853470802307129}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF1b":["L2523F"],"ORF3a":["V80A"],"S":["R346T","F456L"]},"labels":{"aa":"ORF1b: L2523F; ORF3a: V80A; S: R346T, F456L","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.176589012145996}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.56445837020874}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.39.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.965569496154785}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.965569496154785}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.303284645080566}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439889430999756}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.42.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.439889430999756}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MS.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.217808246612549}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"ORF1a":["E940G"],"S":["S31-"]},"labels":{"aa":"ORF1a: E940G; S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-18"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"ORF1a":["N1540S"]},"labels":{"aa":"ORF1a: N1540S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.50.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.046438694000244}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"ME.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.27215999999999985"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894906520843506}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.894906520843506}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834674835205078}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.53.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.834674835205078}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000860","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2595099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF1a":["T2152I"],"ORF3a":["L85F"],"S":["T572I"]},"labels":{"aa":"ORF1a: T2152I; ORF3a: L85F; S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.65.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.2","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"ORF1b":["S2339F"],"S":["S60P","W64L"]},"labels":{"aa":"ORF1b: S2339F; S: S60P, W64L","spike_mutations":"S60P, W64L"}}},{"name":"MF.1","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"internal_21507594","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343885898590088}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.343885898590088}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000864","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548393249511719}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.30.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.548393249511719}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.693490982055664}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.125247478485107}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF1a":["I1128F","T2283I"],"ORF7b":["L20I"]},"labels":{"aa":"ORF1a: I1128F, T2283I; ORF7b: L20I"}}},{"name":"KU.2.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KU.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688675403594971}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"ORF1a":["P2739L"],"S":["G213E"]},"labels":{"aa":"ORF1a: P2739L; S: G213E","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9566946029663086}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.10456657409668}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.530190467834473}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000868","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"ORF1a":["A427V"]},"labels":{"aa":"ORF1a: A427V"}}},{"name":"internal_137393d6","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF1a":["T1761I"],"ORF3a":["S60F"]},"labels":{"aa":"ORF1a: T1761I; ORF3a: S60F"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.48.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"ORF1a":["T677I"],"S":["T572I"]},"labels":{"aa":"ORF1a: T677I; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000871","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.491114616394043}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000872","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4388251304626465}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.623403549194336}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000873","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.617250919342041}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"ORF1a":["N3774D"]},"labels":{"aa":"ORF1a: N3774D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.779577732086182}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.779577732086182}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.424570083618164}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.15.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.753198623657227}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.0455780029296875}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":141,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-20"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF1a":["T1000I"],"ORF1b":["P970T"],"ORF7b":["F13L"],"S":["Q677P"]},"labels":{"aa":"ORF1a: T1000I; ORF1b: P970T; ORF7b: F13L; S: Q677P","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.396686553955078}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LU.2.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":96},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF1a":["L204F","T1854I"],"ORF9b":["L64P"],"S":["S60P","K182N"]},"labels":{"aa":"ORF1a: L204F, T1854I; ORF9b: L64P; S: S60P, K182N","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"NODE_0000879","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.62368106842041}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}},"children":[{"name":"JN.1.28","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":86},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.62368106842041}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000880","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24370T"],"ORF1a":["P1640L"]},"labels":{"aa":"ORF1a: P1640L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.28.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000881","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.9318500000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3745641202332524"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000882","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"ORF1b":["R2009K"],"S":["F456L"]},"labels":{"aa":"ORF1b: R2009K; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000883","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7748894691467285}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.327071189880371}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.49","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.7748894691467285}},"branch_attrs":{"mutations":{}}},{"name":"internal_d6241d6f","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.5151262283325195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.49.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"ORF1a":["D571A"]},"labels":{"aa":"ORF1a: D571A"}}},{"name":"internal_0257fb60","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"S":["S31F","F456V"]},"labels":{"aa":"S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"ORF1a":["E670K"]},"labels":{"aa":"ORF1a: E670K"}}},{"name":"NODE_0000887","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000888","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"ORF1a":["T224I"]},"labels":{"aa":"ORF1a: T224I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MB.1.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MV.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.30217999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000889","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309098243713379}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.309098243713379}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.409302234649658}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.224720478057861}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.8731584548950195}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.58.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.8731584548950195}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.486703395843506}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"ORF1a":["T3665K"],"S":["F456L"]},"labels":{"aa":"ORF1a: T3665K; S: F456L","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"ORF1a":["A2529V"],"ORF1b":["T1139S"],"S":["V62F","F456V"]},"labels":{"aa":"ORF1a: A2529V; ORF1b: T1139S; S: V62F, F456V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.53473424911499}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"ORF1a":["N2147S"]},"labels":{"aa":"ORF1a: N2147S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.53473424911499}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3433942794799805}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.64.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3433942794799805}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"ORF1a":["T2800I"],"S":["F456V"]},"labels":{"aa":"ORF1a: T2800I; S: F456V","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917654037475586}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.917654037475586}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}},{"name":"MD.3","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MD.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.225796699523926}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.005701065063477}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.9326603412628174}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"KS.1.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"ORF1a":["L2146F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L2146F; S: T22N","spike_mutations":"T22N"}}},{"name":"KS.1.3","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KS.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.098504066467285}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"ORF1b":["A1219S"]},"labels":{"aa":"ORF1b: A1219S"}},"children":[{"name":"JN.1.57.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"ORF1a":["I3693V"],"S":["S60P"]},"labels":{"aa":"ORF1a: I3693V; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.57","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_dd754174","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.730973243713379}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"ORF1b":["C1563F"]},"labels":{"aa":"ORF1b: C1563F"}}},{"name":"JN.1.7","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.730973243713379}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.287435054779053}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.08313"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.566638469696045}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69068717956543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.6","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"ORF1a":["P1609S"],"S":["S60P"]},"labels":{"aa":"ORF1a: P1609S; S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.7.7","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-05"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.175660610198975}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"ORF1b":["K2557R"]},"labels":{"aa":"ORF1b: K2557R"}}},{"name":"JN.1.7.9","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"ORF1a":["V28I"],"S":["F456L"]},"labels":{"aa":"ORF1a: V28I; S: F456L","spike_mutations":"F456L"}}},{"name":"NODE_0000903","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000904","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}},{"name":"MQ.2","node_attrs":{"div":140,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MQ.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF1a":["P892S"],"ORF9b":["V96A"],"S":["T678I"]},"labels":{"aa":"ORF1a: P892S; ORF9b: V96A; S: T678I","spike_mutations":"T678I"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"ORF1a":["H3395Y"]},"labels":{"aa":"ORF1a: H3395Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.7.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347303867340088}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.04395"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"ORF1a":["R1170C","L3606F"],"S":["H445P"]},"labels":{"aa":"ORF1a: R1170C, L3606F; S: H445P","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.993319988250732}},"branch_attrs":{"mutations":{}}},{"name":"LK.2.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.95433"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-03"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.712064027786255}},"branch_attrs":{"mutations":{"nuc":["C774T"],"ORF1a":["T170I"]},"labels":{"aa":"ORF1a: T170I"}},"children":[{"name":"JN.1.4.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.776793003082275}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-08"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.712064027786255}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.4","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.743773937225342}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.924510955810547}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1655168533325195}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000909","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-2.8164446353912354}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.0372114181518555}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.373998641967773}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.4685418605804443}},"branch_attrs":{"mutations":{}}},{"name":"KV.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"KV.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"ORF1a":["P971L"],"S":["T572I"]},"labels":{"aa":"ORF1a: P971L; S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.78267240524292}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.78267240524292}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.02389"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000913","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769777297973633}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.769777297973633}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.145885944366455}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"ORF1b":["T730I"],"S":["K304N"]},"labels":{"aa":"ORF1b: T730I; S: K304N","spike_mutations":"K304N"}}},{"name":"NODE_0000914","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.3.1","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LE.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5280601978302}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"ORF1a":["F499L"]},"labels":{"aa":"ORF1a: F499L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-11-28"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.5280601978302}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.900146484375}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21984999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"ORF1a":["S2083I"],"S":["H445P","F456L"]},"labels":{"aa":"ORF1a: S2083I; S: H445P, F456L","spike_mutations":"H445P, F456L"}}},{"name":"internal_e3b87428","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6427741050720215}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6427741050720215}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000917","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.973682403564453}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-09"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.973682403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621864318847656}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"ORF1b":["V1092F"]},"labels":{"aa":"ORF1b: V1092F"}},"children":[{"name":"KZ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.621864318847656}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KZ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"ORF1a":["L1546I"],"S":["T572I"]},"labels":{"aa":"ORF1a: L1546I; S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000921","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.3227319717407227}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-12-02"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.391620635986328}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.10","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-14"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.88560676574707}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-12"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.850419044494629}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000922","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-01"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"ORF1a":["L642F","T2087I"]},"labels":{"aa":"ORF1a: L642F, T2087I"}}},{"name":"NODE_0000923","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"ORF1b":["I1539T"],"S":["Q218E"]},"labels":{"aa":"ORF1b: I1539T; S: Q218E","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":142,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.4.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":11.111},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000924","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}},{"name":"KR.1.2","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.3","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"KR.1.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"ORF1a":["L204F","Q455K","I2346V"],"S":["S60P","K304Q"]},"labels":{"aa":"ORF1a: L204F, Q455K, I2346V; S: S60P, K304Q","spike_mutations":"S60P, K304Q"}}}]}]}]}]},{"name":"internal_3e3e","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056468486785889}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-09"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.056468486785889}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.607524394989014}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"ORF1a":["A3143V"],"S":["T572I"]},"labels":{"aa":"ORF1a: A3143V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.143589496612549}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.9.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.143589496612549}},"branch_attrs":{"mutations":{}}},{"name":"internal_58d7eb29","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-3.996467113494873}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"ORF1a":["A2508D"],"S":["V1104L"]},"labels":{"aa":"ORF1a: A2508D; S: V1104L","spike_mutations":"V1104L"}}},{"name":"LB.1.6","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.695790767669678}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"ORF1a":["S2517P"],"S":["I670M"]},"labels":{"aa":"ORF1a: S2517P; S: I670M","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"ORF1b":["T1621I"],"S":["L1143F"]},"labels":{"aa":"ORF1b: T1621I; S: L1143F","spike_mutations":"L1143F"}}},{"name":"LB.1.9","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.2408299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"LB.1.8","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.729199409484863}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"ORF1a":["I785V"],"S":["-31S"]},"labels":{"aa":"ORF1a: I785V; S: -31S","spike_mutations":"-31S"}}},{"name":"NODE_0000928","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"ORF1a":["A1473V"]},"labels":{"aa":"ORF1a: A1473V"}},"children":[{"name":"LB.1.4.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.558183670043945}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.3","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.4.3"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-24"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000929","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"ORF1b":["G2068R"]},"labels":{"aa":"ORF1b: G2068R"}},"children":[{"name":"LB.1.2.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.662585735321045}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"ORF1a":["I1568F"],"S":["F175L"]},"labels":{"aa":"ORF1a: I1568F; S: F175L","spike_mutations":"F175L"}}},{"name":"LB.1.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.624434947967529}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.1423444747924805}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.3","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-13"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000931","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883640289307}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"ORF1b":["T1555I"]},"labels":{"aa":"ORF1b: T1555I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.111883640289307}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF1a":["V84-","M85-"],"ORF7a":["T28I"],"S":["H445P"]},"labels":{"aa":"N: T379I; ORF1a: V84-, M85-; ORF7a: T28I; S: H445P","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.472174644470215}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LB.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-01"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.063838005065918}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-10"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.347520351409912}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_dc847259","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.416768550872803}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.416768550872803}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LA.2","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.04741999999999978"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.465664863586426}},"branch_attrs":{"mutations":{"S":["T346I"]},"labels":{"aa":"S: T346I","spike_mutations":"T346I"}}},{"name":"LA.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.685051918029785}},"branch_attrs":{"mutations":{"nuc":["T22599C"]}}}]}]},{"name":"NODE_0000936","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.71908712387085}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.012791156768799}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF1a":["G400S"],"ORF7a":["F59K"]},"labels":{"aa":"ORF1a: G400S; ORF7a: F59K"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MT.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_acb00454","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.085048198699951}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.085048198699951}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.096623420715332}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF1a":["K247R"],"ORF3a":["Y184H"],"S":["S31-"]},"labels":{"aa":"ORF1a: K247R; ORF3a: Y184H; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.6","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":143,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":50.174},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.21767999999999987"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.817229820305529"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF1a":["S2535L"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"]},"labels":{"aa":"ORF1a: S2535L; ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"ORF1a":["T4368I"]},"labels":{"aa":"N: R385K; ORF1a: T4368I"}},"children":[{"name":"LF.4.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF1a":["G519S"],"ORF8":["Q29*"],"S":["S31-"]},"labels":{"aa":"ORF1a: G519S; ORF8: Q29*; S: S31-","spike_mutations":"S31-"}}},{"name":"LF.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"ORF1a":["A1268T","S2103F"]},"labels":{"aa":"ORF1a: A1268T, S2103F"}},"children":[{"name":"LF.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.688045501708984}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF1a":["A4285V"],"ORF8":["I121-"]},"labels":{"aa":"ORF1a: A4285V; ORF8: I121-"}},"children":[{"name":"LF.3","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LF.3.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}}]}]},{"name":"NODE_0000944","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671684741973877}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.671684741973877}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000945","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"LF.5","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","C21740T","C28660T"],"S":["T33A","P60S"]},"labels":{"aa":"S: T33A, P60S","spike_mutations":"T33A, P60S"}}},{"name":"LF.9.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.9.1"},"designation_recency":{"value":"3-4 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-27"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.6747589111328125}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000946","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000947","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1.1","node_attrs":{"div":138,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"ORF1a":["L4391F"],"S":["T22N"]},"labels":{"aa":"ORF1a: L4391F; S: T22N","spike_mutations":"T22N"}}},{"name":"LF.8.1","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LF.8.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"ORF1b":["Y1588H"]},"labels":{"aa":"ORF1b: Y1588H"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.107455253601074}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":129,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-04"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.107455253601074}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"ORF1a":["A690V"],"ORF1b":["S2339F"],"S":["S31-"]},"labels":{"aa":"ORF1a: A690V; ORF1b: S2339F; S: S31-","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958076000213623}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.958076000213623}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"ORF1a":["E940D","A2584T"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"]},"labels":{"aa":"ORF1a: E940D, A2584T; S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688903331756592}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.688903331756592}},"branch_attrs":{"mutations":{}}},{"name":"LH.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.2212395668029785}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"ORF1a":["G604S"],"S":["K182I"]},"labels":{"aa":"ORF1a: G604S; S: K182I","spike_mutations":"K182I"}}},{"name":"LH.2","node_attrs":{"div":137,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"ORF1a":["E1766A"],"S":["I197V","P251H"]},"labels":{"aa":"ORF1a: E1766A; S: I197V, P251H","spike_mutations":"I197V, P251H"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.83402681350708}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.83402681350708}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.255953788757324}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"S":["S31-","R190S"]},"labels":{"aa":"S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.795686721801758}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3794899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MA.1.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":11.111},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3926199999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451968669891357}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-14"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.451968669891357}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"ORF1a":["T1761I"]},"labels":{"aa":"ORF1a: T1761I"}}},{"name":"internal_7901df09","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.52098274230957}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"ORF1a":["T183A"],"S":["N556K"]},"labels":{"aa":"ORF1a: T183A; S: N556K","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1.1","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.721519947052002}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}},{"name":"LQ.1","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.992994785308838}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000957","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.106265068054199}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":133,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-7.748869895935059}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"MN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"ORF1b":["L1351F"],"S":["D80Y","P174S","S689N"]},"labels":{"aa":"ORF1b: L1351F; S: D80Y, P174S, S689N","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"internal_d540cdaa","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172470569610596}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":131,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.172470569610596}},"branch_attrs":{"mutations":{}}},{"name":"LY.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"ORF1a":["T2002M","A3235T"],"S":["Q183H"]},"labels":{"aa":"ORF1a: T2002M, A3235T; S: Q183H","spike_mutations":"Q183H"}}},{"name":"LY.1","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.744577884674072}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}}]},{"name":"NODE_0000960","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":132,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.18.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.14224"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5525967162870884"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":88},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{}}},{"name":"internal_41eb7227","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"ORF1a":["I740V"],"S":["F456L"]},"labels":{"aa":"N: A152T; ORF1a: I740V; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.1","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LZ.1.1","node_attrs":{"div":139,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}}]},{"name":"NODE_0000962","node_attrs":{"div":134,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G","T22928C"],"ORF1a":["K1226E"],"S":["F456L"]},"labels":{"aa":"ORF1a: K1226E; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":135,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2.1"},"designation_recency":{"value":"2-3 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-09-05"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C29642T"]}}},{"name":"LZ.2","node_attrs":{"div":136,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"LZ.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"clade_membership":{"value":"24A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":130,"clade_display":{"value":"24A (JN.1)"},"Nextclade_pango":{"value":"JN.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24A"},"ace2_binding":{"value":"1.03082"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.3729573686780503"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-11"},"totalAminoacidSubstitutions":{"value":87},"clade_nextstrain":{"value":"24A"},"placement_prior":{"value":-4.858862400054932}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":132,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299810886383057}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"ORF1a":["T2283I"],"S":["F456L"]},"labels":{"aa":"ORF1a: T2283I; S: F456L","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":132,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"JN.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-01-22"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299810886383057}},"branch_attrs":{"mutations":{}}},{"name":"KP.6","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.04741999999999978"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.009568691253662}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"KP.5","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.512091159820557}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_181bd2e5","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":89},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000966","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.726853370666504}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.27333999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7741516492587035"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"ORF1a":["M598V"],"S":["S31-"]},"labels":{"aa":"ORF1a: M598V; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"ORF1b":["T132I"]},"labels":{"aa":"ORF1b: T132I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.4.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"ORF1a":["G519S","I2227V"],"S":["G35R"]},"labels":{"aa":"ORF1a: G519S, I2227V; S: G35R","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000970","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679379463195801}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-02-22"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.679379463195801}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.20671999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5128878466365139"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.064725875854492}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"ORF1b":["L2213F"],"S":["K182N"]},"labels":{"aa":"ORF1b: L2213F; S: K182N","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-25"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"ORF1a":["V3091I"],"S":["T572I","K679N"]},"labels":{"aa":"ORF1a: V3091I; S: T572I, K679N","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.784816741943359}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MU.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"ORF1a":["P4339T"],"ORF1b":["T1902I"],"S":["T572I"]},"labels":{"aa":"ORF1a: P4339T; ORF1b: T1902I; S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923413038253784}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.923413038253784}},"branch_attrs":{"mutations":{}}},{"name":"LP.3","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"ORF1b":["R276S"],"S":["K182E"]},"labels":{"aa":"ORF1b: R276S; S: K182E","spike_mutations":"K182E"}}},{"name":"LP.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"ORF1b":["T2376I"],"S":["S71Y"]},"labels":{"aa":"ORF1b: T2376I; S: S71Y","spike_mutations":"S71Y"}}},{"name":"LP.4","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_bfd296bd","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928688049316}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.200928688049316}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000976","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"LP.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"NODE_0000977","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013410568237305}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":133,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-04"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.8013410568237305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.11","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"ORF1a":["T2093I"],"S":["L56V"]},"labels":{"aa":"ORF1a: T2093I; S: L56V","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.12","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"ORF1a":["E199K"],"S":["V1176F"]},"labels":{"aa":"ORF1a: E199K; S: V1176F","spike_mutations":"V1176F"}}},{"name":"KP.2.14","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.1","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.616664409637451}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.19","node_attrs":{"div":140,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.19"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":1.562},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"ORF1a":["V28I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V28I; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.23"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.24"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.083328723907471}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"ORF1b":["K1671I"],"S":["S60P"]},"labels":{"aa":"ORF1b: K1671I; S: S60P","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.675713062286377}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.15.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"ORF1b":["D436N"]},"labels":{"aa":"ORF1b: D436N"}},"children":[{"name":"KP.2.20.1","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.0966644287109375}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}},{"name":"KP.2.20","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.20"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-7.767837047576904}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_53692388","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-04-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000981","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"-0.40119000000000016"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7908990401504723"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.4","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3312699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"KP.2.3.3","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000982","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"ORF1a":["T2121A"]},"labels":{"aa":"ORF1a: T2121A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":137,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.3.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":140,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"MW.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":96},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF1a":["I785V"],"ORF6":["L16I"],"S":["Q239R"]},"labels":{"aa":"ORF1a: I785V; ORF6: L16I; S: Q239R","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000983","node_attrs":{"div":134,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2"},"clade_membership":{"value":"24B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.91617751121521}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":139,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.21942999999999988"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7334333297137097"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.17","node_attrs":{"div":138,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.16","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.532774448394775}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.18"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-07"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.196527481079102}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-19"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":136,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.22"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"ORF1a":["V3718F"],"S":["S31-"]},"labels":{"aa":"ORF1a: V3718F; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.321987152099609}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":135,"clade_display":{"value":"24B (JN.1.11.1)"},"Nextclade_pango":{"value":"KP.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24B"},"ace2_binding":{"value":"0.3181399999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7057624932604036"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000984","node_attrs":{"div":133,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987264633178711}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":133,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-03-17"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.987264633178711}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.6","node_attrs":{"div":134,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.770003318786621}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.3.5","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"internal_123a0013","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094734191894531}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.094734191894531}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.4.1","node_attrs":{"div":141,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"ORF1a":["E1192K"],"S":["S31F"]},"labels":{"aa":"N: A134V; ORF1a: E1192K; S: S31F","spike_mutations":"S31F"}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.2","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5554650921238282"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-10"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"ORF1a":["N4134T"],"S":["A435S"]},"labels":{"aa":"ORF1a: N4134T; S: A435S","spike_mutations":"A435S"}}},{"name":"KP.3.3.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"NODE_0000987","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"ORF1a":["I1367L"]},"labels":{"aa":"ORF1a: I1367L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MR.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"ORF1a":["V1236I"],"S":["S31-"]},"labels":{"aa":"ORF1a: V1236I; S: S31-","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"ML.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9914960861206055}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2.1","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-29"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.486746788024902}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.9914960861206055}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.2","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-30"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.5","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-09"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.35004997253418}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"KP.3.2.4","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.093895435333252}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"internal_f3994b77","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000991","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":140,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":142,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":94},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"ORF1a":["P2792S"],"S":["T33I"]},"labels":{"aa":"ORF1a: P2792S; S: T33I","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":142,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"LW.1.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000992","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":135,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-16"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-3.6072957515716553}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.5","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-17"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF1a":["Q998H"],"ORF3a":["I186V"],"S":["N556K"]},"labels":{"aa":"ORF1a: Q998H; ORF3a: I186V; S: N556K","spike_mutations":"N556K"}}},{"name":"KP.3.1.7","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"NODE_0000993","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.380892753601074}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":141,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MY.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.174},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-16"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"ORF1b":["P1675S"]},"labels":{"aa":"ORF1b: P1675S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000995","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":90},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.658258438110352}},"branch_attrs":{"mutations":{}}},{"name":"MK.2","node_attrs":{"div":137,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.1","node_attrs":{"div":138,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-07-12"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.3","node_attrs":{"div":143,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"MK.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.694},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.11924"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.7206397516519647"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":95},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"ORF1a":["L293F","S1272G","T2069N","D2592Y"],"S":["R346T","H445R"]},"labels":{"aa":"ORF1a: L293F, S1272G, T2069N, D2592Y; S: R346T, H445R","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":136,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1"},"clade_membership":{"value":"24C"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":139,"clade_display":{"value":"24C (KP.3)"},"Nextclade_pango":{"value":"KP.3.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24C"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-04"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"ORF1a":["A2129V"],"S":["S151I"]},"labels":{"aa":"ORF1a: A2129V; S: S151I","spike_mutations":"S151I"}}},{"name":"NODE_0000997","node_attrs":{"div":137,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"ORF1a":["S4286C"],"S":["S31-"]},"labels":{"aa":"ORF1a: S4286C; S: S31-","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":137,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"KP.3.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-05-28"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-06-29"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.10"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.12"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.14","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.14"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.028985977172852}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.15","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.15"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.16"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-3.9109444618225098}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.3","node_attrs":{"div":142,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.3"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.4","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.4"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.6","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.6"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.380198001861572}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"ORF1a":["P769S","G2091S"]},"labels":{"aa":"ORF1a: P769S, G2091S"}}},{"name":"MC.5","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.5"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.7","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.7"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.3172000000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5369762101413171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-6.5447492599487305}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.9","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.9"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.347928524017334}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF1b":["A1219S"],"ORF3a":["K75N"]},"labels":{"aa":"ORF1b: A1219S; ORF3a: K75N"}}},{"name":"NODE_0000998","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":140,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.11.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000999","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13.1","node_attrs":{"div":140,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}},{"name":"MC.13","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.13"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2.1","node_attrs":{"div":139,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.050478458404541}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}},{"name":"MC.2","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.2"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-08"},"totalAminoacidSubstitutions":{"value":92},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_836f2465","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"clade_membership":{"value":"24E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":138,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":91},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":142,"clade_display":{"value":"24E (KP.3.1.1)"},"Nextclade_pango":{"value":"MC.8.1"},"designation_recency":{"value":"4-8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"24E"},"ace2_binding":{"value":"-1.15353"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"1.5260901910056954"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2024-08-15"},"totalAminoacidSubstitutions":{"value":93},"clade_nextstrain":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":74,"clade_display":{"value":"21L (BA.2)"},"Nextclade_pango":{"value":"B.1.1.529"},"clade_membership":{"value":"21L"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21L"},"placement_prior":{"value":-3.767807722091675}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0001003","node_attrs":{"div":75,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.517561435699463}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":75,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.517561435699463}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001004","node_attrs":{"div":76,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.3251705169677734}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF1a":["K141-","S142-","F143-"],"ORF7b":["L11F"]},"labels":{"aa":"ORF1a: K141-, S142-, F143-; ORF7b: L11F"}},"children":[{"name":"BA.4","node_attrs":{"div":76,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.3251705169677734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"ORF1a":["H1636Q"]},"labels":{"aa":"ORF1a: H1636Q"}}},{"name":"NODE_0001005","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.9142704010009766}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.5","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.3","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"ORF1b":["P2633L"]},"labels":{"aa":"ORF1b: P2633L"}}},{"name":"BA.4.4","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.222130298614502}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.7","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.027553558349609}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0001006","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6.1","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-05"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.979905843734741}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.3","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.71883"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.3"},"totalAminoacidDeletions":{"value":18},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.4821672439575195}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"ORF1a":["G963C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: G963C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.2","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"ORF1a":["D1323G","M2259I"],"S":["V445A"]},"labels":{"aa":"ORF1a: D1323G, M2259I; S: V445A","spike_mutations":"V445A"}}},{"name":"BA.4.6","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.7857272624969482}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.4","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0001007","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.6.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":82,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"DC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.66094"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.6.5.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"internal_813c","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.69476318359375}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":77,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-2.69476318359375}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.729525566101074}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.5","node_attrs":{"div":79,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.5"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"BA.4.1.4","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.4"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":80,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF1a":["R724G"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: R724G; ORF9b: P51L"}}},{"name":"BA.4.1.6","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.6"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"ORF1a":["T4355I"]},"labels":{"aa":"ORF1a: T4355I"}}},{"name":"BA.4.1.9","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-27"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.872365713119507}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"BA.4.1.8"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-3.857666492462158}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001009","node_attrs":{"div":78,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"ORF1b":["L314F"]},"labels":{"aa":"ORF1b: L314F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.2"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF1a":["P971S"],"ORF7a":["P84L"]},"labels":{"aa":"ORF1a: P971S; ORF7a: P84L"}}},{"name":"BA.4.1.7","node_attrs":{"div":83,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.7"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"ORF1a":["D1940G"],"ORF1b":["D1825G"],"S":["Q52R"]},"labels":{"aa":"ORF1a: D1940G; ORF1b: D1825G; S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001010","node_attrs":{"div":79,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":86,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.11"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0001011","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"clade_membership":{"value":"22A"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":81,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"BA.4.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.67074"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.5308081831240151"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":87,"clade_display":{"value":"22A (BA.4)"},"Nextclade_pango":{"value":"CS.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22A"},"ace2_binding":{"value":"0.5702799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.4.1.10.1"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.7561969850799493"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"ORF1b":["E1264D"],"S":["K444R"]},"labels":{"aa":"ORF1b: E1264D; S: K444R","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0001012","node_attrs":{"div":83,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.145464897155762}},"branch_attrs":{"mutations":{"nuc":["C1931A","G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF1a":["Q556K"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF1a: Q556K; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-04-06"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.918104648590088}},"branch_attrs":{"mutations":{"nuc":["A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}}},{"name":"BA.5.3.1","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.109306812286377}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"BA.5.3","node_attrs":{"div":83,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.145464897155762}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:72-122"},"partiallyAliased":{"value":"BA.5.3.3"},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.781851291656494}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","S2193F"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-, S2193F; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-"}}},{"name":"BA.5.3.5","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.5"},"totalAminoacidDeletions":{"value":36},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.9","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2392046451568604}},"branch_attrs":{"mutations":{"nuc":["T1570C","A1931C","C11514T","C11674T","C17676T","C18804T","G22599T"],"ORF1a":["K556Q","T3750I"],"S":["R346I"]},"labels":{"aa":"ORF1a: K556Q, T3750I; S: R346I","spike_mutations":"R346I"}}},{"name":"BE.2","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.800013303756714}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G","C13342T","G28681T"],"N":["E136D"],"ORF1a":["T882I"]},"labels":{"aa":"N: E136D; ORF1a: T882I"}}},{"name":"BE.3","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.220089912414551}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","G28681T","C28724T"],"N":["E136D","P151S"],"ORF1b":["Y1247C"]},"labels":{"aa":"N: E136D, P151S; ORF1b: Y1247C"}}},{"name":"BE.5","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.109306812286377}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}}},{"name":"NODE_0001013","node_attrs":{"div":84,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8083324432373047}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.4","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.250558853149414}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"ORF1b":["M2417I"]},"labels":{"aa":"ORF1b: M2417I"}}},{"name":"BA.5.3.2","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-13"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.920682430267334}},"branch_attrs":{"mutations":{"nuc":["G621A"],"ORF1a":["R119H"]},"labels":{"aa":"ORF1a: R119H"}}}]},{"name":"NODE_0001014","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.902167558670044}},"branch_attrs":{"mutations":{"nuc":["A1931C","A6551C","G29032A"],"ORF1a":["K556Q","M2096L"]},"labels":{"aa":"ORF1a: K556Q, M2096L"}},"children":[{"name":"BA.5.8","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-24"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"ORF1b":["V1271L","T2376I"],"S":["P1162L"]},"labels":{"aa":"ORF1b: V1271L, T2376I; S: P1162L","spike_mutations":"P1162L"}}},{"name":"BA.5.7","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF1a":["E91K","T350I"],"ORF7a":["H47D"]},"labels":{"aa":"ORF1a: E91K, T350I; ORF7a: H47D"}}}]},{"name":"NODE_0001015","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420078754425049}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A","G28681T"],"N":["E136D"],"S":["K444T","N460K"]},"labels":{"aa":"N: E136D; S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"ORF1a":["S74L","S2822F","M3911T"]},"labels":{"aa":"ORF1a: S74L, S2822F, M3911T"}}},{"name":"BE.9","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.9"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6684834957122803}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"ORF1a":["V84-","M85-"],"S":["Y144-"]},"labels":{"aa":"ORF1a: V84-, M85-; S: Y144-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0001016","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2845587730407715}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T","G28681T","T28693C"],"N":["E136D"],"ORF1a":["M85-"]},"labels":{"aa":"N: E136D; ORF1a: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.6"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.737102031707764}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BE.7","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.7"},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.387746334075928}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001017","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.943603277206421}},"branch_attrs":{"mutations":{"nuc":["A1931C","C21789T"],"ORF1a":["K556Q"],"S":["T76I"]},"labels":{"aa":"ORF1a: K556Q; S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.243032455444336}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"ORF1b":["G662V"]},"labels":{"aa":"ORF1b: G662V"}}},{"name":"BA.5.5","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-06"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.943603277206421}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001018","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.891446590423584}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5124127864837646}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"ORF1a":["V3166F"],"ORF1b":["L314R"]},"labels":{"aa":"ORF1a: V3166F; ORF1b: L314R"}}}]}]},{"name":"NODE_0001019","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.720151901245117}},"branch_attrs":{"mutations":{"nuc":["G28681T","T28693C"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BE.12","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0075602531433105}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0001020","node_attrs":{"div":86,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.3.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236769199371338}},"branch_attrs":{"mutations":{"nuc":["A518-","G22599C","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF1a":["M85-"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF1a: M85-; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5231200000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.13"},"totalAminoacidDeletions":{"value":95},"immune_escape":{"value":"0.5088823627149919"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","T2665C","C3176T","A22995G","C23802T","A26170G","C27393T","A27508-","C27509-","A27510-","T27511-"],"ORF1a":["P971S"],"ORF3a":["M260V"],"ORF7a":["T39-"],"S":["K478R","T747I"]},"labels":{"aa":"ORF1a: P971S; ORF3a: M260V; ORF7a: T39-; S: K478R, T747I","spike_mutations":"K478R, T747I"}}},{"name":"BE.8","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":56.25},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.8"},"totalAminoacidDeletions":{"value":94},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":1},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["T519-","G520-","C1853T","C14178T","C22498T","C26110T","A27748-"],"ORF3a":["P240S"],"ORF7a":["K119*"]},"labels":{"aa":"ORF3a: P240S; ORF7a: K119*"}}}]}]},{"name":"NODE_0001021","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{"nuc":["C10188A","C13342T","C27800T","G28681T"],"N":["E136D"],"ORF1a":["T3308N"]},"labels":{"aa":"N: E136D; ORF1a: T3308N"}},"children":[{"name":"BE.4","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.245569229125977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001022","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.281350135803223}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.6132917404174805}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0001023","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"ORF1a":["T1168I"],"S":["P209L","R346T"]},"labels":{"aa":"ORF1a: T1168I; S: P209L, R346T","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001024","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.4.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.919694185256958}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"ORF1a":["H1141Y"],"S":["Y144-","V445A"]},"labels":{"aa":"ORF1a: H1141Y; S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0001025","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"CQ.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0001026","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075679063796997}},"branch_attrs":{"mutations":{"nuc":["A1931C","T4906C","C17402T","T18957C","C21077T"],"ORF1a":["K556Q"],"ORF1b":["A1312V","T2537I"]},"labels":{"aa":"ORF1a: K556Q; ORF1b: A1312V, T2537I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.075679063796997}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001027","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1130266189575195}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"ORF1b":["M1839I"]},"labels":{"aa":"ORF1b: M1839I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.963254690170288}},"branch_attrs":{"mutations":{"nuc":["T29597C"]}}},{"name":"BA.5.6.4","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5883099999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}},{"name":"BA.5.6.3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001028","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.6.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001029","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"ORF1a":["V627I"],"S":["N460K"]},"labels":{"aa":"ORF1a: V627I; S: N460K","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6570799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"ORF1a":["I1551V"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: I1551V; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0001030","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-20"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"ORF1b":["P1001S"]},"labels":{"aa":"ORF1b: P1001S"}}},{"name":"BW.1.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BW.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77355"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"ORF1a":["L864F"]},"labels":{"aa":"ORF1a: L864F"}}}]}]}]}]},{"name":"NODE_0001031","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2636122703552246}},"branch_attrs":{"mutations":{"nuc":["A1T","A1931C","T27438C","C29666T"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.1","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-11"},"totalAminoacidSubstitutions":{"value":50},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.2636122703552246}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.11","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"ORF1a":["I2368T","Q3922R"]},"labels":{"aa":"N: A211S; ORF1a: I2368T, Q3922R"}}},{"name":"BA.5.1.12","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.42498517036438}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.9656171798706055}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"ORF1a":["S2396I"]},"labels":{"aa":"ORF1a: S2396I"}}},{"name":"BA.5.1.16","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.953991413116455}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF1a":["M902V"],"ORF7a":["G26D"]},"labels":{"aa":"ORF1a: M902V; ORF7a: G26D"}}},{"name":"BA.5.1.17","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.774555206298828}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.263641834259033}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.24","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.364013195037842}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"ORF1b":["V1271L"]},"labels":{"aa":"ORF1b: V1271L"}}},{"name":"BA.5.1.3","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1492865085601807}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.28","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.255985736846924}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.30","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9020943641662598}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.34"},"totalAminoacidDeletions":{"value":20},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0658464431762695}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"ORF1a":["G82-","H83-","V84-","M85-","P626L"],"S":["K147-","N148-","P1162S"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, P626L; S: K147-, N148-, P1162S","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.5","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-20"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.146693468093872}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.6","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.541465997695923}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"ORF1a":["V1453I"]},"labels":{"aa":"ORF1a: V1453I"}}},{"name":"BA.5.1.4","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-03"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"ORF1a":["V1117I","S1510C"],"ORF1b":["R1078L"]},"labels":{"aa":"ORF1a: V1117I, S1510C; ORF1b: R1078L"}}},{"name":"BA.5.1.7","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8861465454101562}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"ORF1b":["A520V","T2332I"]},"labels":{"aa":"ORF1b: A520V, T2332I"}}},{"name":"BA.5.1.8","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6324868202209473}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"ORF1a":["T4161I"],"ORF1b":["T2548I"]},"labels":{"aa":"ORF1a: T4161I; ORF1b: T2548I"}}},{"name":"NODE_0001032","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF1a":["K3839R"],"ORF9b":["T60I"]},"labels":{"aa":"ORF1a: K3839R; ORF9b: T60I"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3359532356262207}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9345109462738037}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"ORF1a":["G519S"]},"labels":{"aa":"ORF1a: G519S"}}}]},{"name":"internal_6f22","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"ORF1a":["H3509Y"]},"labels":{"aa":"ORF1a: H3509Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.096940994262695}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0001034","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213008403778076}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"ORF1b":["S1273L"]},"labels":{"aa":"ORF1b: S1273L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.213008403778076}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.22.1"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"ORF1a":["T2093I","A2199T","S2731G"],"S":["Y145-","H146-"]},"labels":{"aa":"ORF1a: T2093I, A2199T, S2731G; S: Y145-, H146-","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0001035","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.26.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.302816867828369}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF1a":["P1692S"],"ORF1b":["V1170I"],"ORF9b":["P51L"]},"labels":{"aa":"ORF1a: P1692S; ORF1b: V1170I; ORF9b: P51L"}}},{"name":"BA.5.1.38","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF1b":["A2589T"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF1b: A2589T; ORF8: S103L; ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198367118835449}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"ORF1a":["I1525M"]},"labels":{"aa":"ORF1a: I1525M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.198367118835449}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.35.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001038","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF1a":["T1444A"],"ORF1b":["G662S"],"ORF9b":["T95M"],"S":["V1264L"]},"labels":{"aa":"ORF1a: T1444A; ORF1b: G662S; ORF9b: T95M; S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416933059692383}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"EQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.33.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.846538543701172}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"ORF1a":["S302F"]},"labels":{"aa":"ORF1a: S302F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.846538543701172}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.23"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1157443523406982}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.33618688583374}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}},{"name":"DE.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.23.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF1a":["A668T"],"ORF1b":["M620T"],"ORF3a":["R134C"],"S":["G181V","R346T"]},"labels":{"aa":"ORF1a: A668T; ORF1b: M620T; ORF3a: R134C; S: G181V, R346T","spike_mutations":"G181V, R346T"}}}]}]},{"name":"NODE_0001041","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4297988414764404}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"ORF1b":["D1903N"]},"labels":{"aa":"ORF1b: D1903N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-28"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF1a":["H417Y"],"ORF1b":["T310I","A1476S"],"ORF7a":["L30H"],"S":["R346T"]},"labels":{"aa":"ORF1a: H417Y; ORF1b: T310I, A1476S; ORF7a: L30H; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001042","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069684028625488}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"ORF1b":["G662S"]},"labels":{"aa":"ORF1b: G662S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.069684028625488}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.21.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_2d50","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806603193283081}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.806603193283081}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.106252193450928}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.106252193450928}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001045","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.244868278503418}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.3","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-23"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"ORF1a":["T3287I"],"ORF1b":["T1697A"]},"labels":{"aa":"ORF1a: T3287I; ORF1b: T1697A"}}},{"name":"DJ.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-10"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF1a":["G82-","H83-","V84-","M85-","V86-","L2869F","I4127V"],"ORF9b":["D2N"],"S":["L176F"]},"labels":{"aa":"N: G5E; ORF1a: G82-, H83-, V84-, M85-, V86-, L2869F, I4127V; ORF9b: D2N; S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0001046","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DJ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"internal_b005","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.52162766456604}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"ORF1b":["N1025S"]},"labels":{"aa":"ORF1b: N1025S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.1.27"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7831974029541016}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-07"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-6.641659259796143}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001049","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"CL.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"NODE_0001050","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.22982931137085}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CL.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"NODE_0001051","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7331035137176514}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.082880973815918}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-04"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047396659851074}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"ORF1b":["G662C"]},"labels":{"aa":"ORF1b: G662C"}}},{"name":"BA.5.1.32","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-15"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF1b":["P1427S","D1565N"],"ORF9b":["V76F"]},"labels":{"aa":"N: S79I, A273S; ORF1b: P1427S, D1565N; ORF9b: V76F"}}},{"name":"BA.5.1.9","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-03"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.180698871612549}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF1b":["M454V"],"ORF6":["D6G"]},"labels":{"aa":"ORF1b: M454V; ORF6: D6G"}}},{"name":"NODE_0001052","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127193450927734}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-07"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.532985687255859}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"ORF1a":["K1407M"]},"labels":{"aa":"ORF1a: K1407M"}}},{"name":"BA.5.1.36","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF1a":["V3892A"],"ORF9b":["L14F"],"S":["G261V"]},"labels":{"aa":"N: G18C; ORF1a: V3892A; ORF9b: L14F; S: G261V","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"NODE_0001053","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024437427520752}},"branch_attrs":{"mutations":{"nuc":["G16935A","G28681T"],"N":["E136D"],"ORF1b":["M1156I"]},"labels":{"aa":"N: E136D; ORF1b: M1156I"}},"children":[{"name":"BE.1","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.024437427520752}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"totalAminoacidDeletions":{"value":17},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"ORF1a":["G82-","H83-","V84-","M85V","L454F"],"S":["M153I","E1258Q"]},"labels":{"aa":"N: P151L; ORF1a: G82-, H83-, V84-, M85V, L454F; S: M153I, E1258Q","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0001054","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.29529333114624}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-10"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.29529333114624}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001055","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"ORF1a":["F678L"],"S":["V445A"]},"labels":{"aa":"ORF1a: F678L; S: V445A","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.28328800201416}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.49383999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8224959014481948"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"ORF1a":["T2836I"],"S":["N460S"]},"labels":{"aa":"ORF1a: T2836I; S: N460S","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0001056","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"ORF1b":["V1787I"]},"labels":{"aa":"ORF1b: V1787I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.3","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"BE.1.4.4","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"NODE_0001057","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF1a":["I3341T"],"ORF1b":["K2557R"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"]},"labels":{"aa":"ORF1a: I3341T; ORF1b: K2557R; ORF8: P93T; ORF9b: S10F; S: R346T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0001058","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708044052124023}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"ORF1a":["L3829F"]},"labels":{"aa":"ORF1a: L3829F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.7708044052124023}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001059","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6190590858459473}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"ORF1a":["K1202N"],"S":["N450D"]},"labels":{"aa":"ORF1a: K1202N; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0001060","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036477565765381}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BE.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.036477565765381}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BQ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45205000000000006"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5680790723509552"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.677981853485107}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0001061","node_attrs":{"div":91,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3800950050354004}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"ORF1b":["Y264H"],"S":["N460K"]},"labels":{"aa":"ORF1b: Y264H; S: N460K","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":91,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-02"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3800950050354004}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.12","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.3855841159820557}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.14","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.436852216720581}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.17","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.19","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6127800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7257362514460642"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.954923629760742}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.20","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5446"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8308113969466171"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4570536613464355}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6570799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"ORF1a":["T2087I"],"S":["Y144-","R346S"]},"labels":{"aa":"ORF1a: T2087I; S: Y144-, R346S","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.423999309539795}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.31","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.428560256958008}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.32","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.4","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"ORF1a":["V2665I"],"S":["R190T"]},"labels":{"aa":"N: H300Q; ORF1a: V2665I; S: R190T","spike_mutations":"R190T"}}},{"name":"BQ.1.33","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.946379661560059}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.6","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9833498001098633}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"ORF1a":["G94C"]},"labels":{"aa":"ORF1a: G94C"}}},{"name":"BQ.1.5","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.459336757659912}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"ORF1b":["T1076I"]},"labels":{"aa":"ORF1b: T1076I"}}},{"name":"BQ.1.7","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.914120197296143}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.9","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.6576948165893555}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"ORF1a":["V2604I"],"S":["R346T"]},"labels":{"aa":"ORF1a: V2604I; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001062","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.11.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-26"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"ORF1a":["H110Y","E1633D"],"S":["L5F","Y144-"]},"labels":{"aa":"ORF1a: H110Y, E1633D; S: L5F, Y144-","spike_mutations":"L5F, Y144-"}}}]},{"name":"NODE_0001063","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"ORF1a":["V627I"]},"labels":{"aa":"ORF1a: V627I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0065107345581055}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0001064","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF1a":["V2157I"],"ORF1b":["P2321L"],"ORF3a":["R68I"]},"labels":{"aa":"ORF1a: V2157I; ORF1b: P2321L; ORF3a: R68I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276405334472656}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0001065","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"ORF1a":["L3116F"]},"labels":{"aa":"ORF1a: L3116F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001066","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.009603500366211}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"ORF1a":["V852A"]},"labels":{"aa":"ORF1a: V852A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.15.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.111164093017578}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"NODE_0001067","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710107326507568}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-12"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.710107326507568}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001068","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF1a":["S248N"],"ORF7b":["A15S"]},"labels":{"aa":"ORF1a: S248N; ORF7b: A15S"}}},{"name":"BQ.1.26.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.26.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"internal_56b3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.176180839538574}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.25.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-21"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8304195404052734}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0001071","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"ORF1a":["L3293I"],"S":["E619Q"]},"labels":{"aa":"ORF1a: L3293I; S: E619Q","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3.2","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.3.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"ORF1a":["L1853F"]},"labels":{"aa":"ORF1a: L1853F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0001073","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"ORF1a":["E352A"]},"labels":{"aa":"ORF1a: E352A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6353800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6853534127590314"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EC.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.579077243804932}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688453674316406}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2.3","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875691413879395}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"BQ.1.2","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4688453674316406}},"branch_attrs":{"mutations":{}}},{"name":"internal_dbfb","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"ORF1b":["P1427S"],"S":["Y144-"]},"labels":{"aa":"N: H300N; ORF1b: P1427S; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"FB.2","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5174000000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6925976779449897"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"ORF1a":["G993D"],"S":["K478R"]},"labels":{"aa":"ORF1a: G993D; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001078","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":105,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66664"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9874397743924017"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF1a":["M85-"],"ORF1b":["E1888K"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"]},"labels":{"aa":"ORF1a: M85-; ORF1b: E1888K; ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0001079","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"ORF1a":["G82-","H83-","V84-"],"S":["F186-","K187-","N188Y"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-; S: F186-, K187-, N188Y","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"totalAminoacidDeletions":{"value":19},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-28"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":109,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"JH.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6059300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7a:83-122"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"totalAminoacidDeletions":{"value":31},"immune_escape":{"value":"1.0821590912755812"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-08-31"},"totalAminoacidSubstitutions":{"value":67},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF1a":["L580F","L730F"],"ORF1b":["V464F","T1453A"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"]},"labels":{"aa":"ORF1a: L580F, L730F; ORF1b: V464F, T1453A; ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A","spike_mutations":"A484K, V486A"}}}]}]}]},{"name":"internal_efa8","node_attrs":{"div":92,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.7586400508880615}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"ORF1b":["N1191S"]},"labels":{"aa":"ORF1b: N1191S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.546395778656006}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"ORF1a":["A540V"]},"labels":{"aa":"ORF1a: A540V"}}},{"name":"BQ.1.23","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4521584510803223}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.057005405426025}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.49690999999999996"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.7651005091732451"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.637411117553711}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"ORF1a":["S505F"],"S":["Y144-"]},"labels":{"aa":"ORF1a: S505F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.8.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":102,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"ORF1a":["I396V"],"ORF1b":["T1511I"],"S":["S256L","Q613H","V1164I"]},"labels":{"aa":"ORF1a: I396V; ORF1b: T1511I; S: S256L, Q613H, V1164I","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0001083","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.392918109893799}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":93,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-09"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-2.392918109893799}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.891563892364502}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-21"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.535731792449951}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"ORF1a":["T4368I"],"S":["S494P"]},"labels":{"aa":"ORF1a: T4368I; S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.16","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.19","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.225134372711182}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.17","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1496901512146}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"ORF1a":["S2273F"]},"labels":{"aa":"ORF1a: S2273F"}}},{"name":"BQ.1.1.21","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.20","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.5311388969421387}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.25","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7449699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.073443412780762}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5921799999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8728938682420008"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-01"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.841209411621094}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.30","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.60833"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9373817650831857"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.31","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8330562114715576}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.36","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.201071739196777}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.314393997192383}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.34","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.100788116455078}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.40","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"ORF1a":["D203N"],"S":["Y144-","S704L"]},"labels":{"aa":"ORF1a: D203N; S: Y144-, S704L","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.44","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.068432331085205}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.45","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.7044315338134766}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.41","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.9046695232391357}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"ORF1a":["A2529V"],"S":["K182I"]},"labels":{"aa":"ORF1a: A2529V; S: K182I","spike_mutations":"K182I"}}},{"name":"BQ.1.1.47","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.249931335449219}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"ORF1a":["V3197M"],"S":["K147I"]},"labels":{"aa":"ORF1a: V3197M; S: K147I","spike_mutations":"K147I"}}},{"name":"BQ.1.1.50","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.386255741119385}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"ORF1a":["K669R"],"ORF1b":["T792I"],"S":["Y144-","I210-"]},"labels":{"aa":"ORF1a: K669R; ORF1b: T792I; S: Y144-, I210-","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995408058166504}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.55","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.861392974853516}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.56","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530673980712891}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.57","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.360785007476807}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.58","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.378429889678955}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.6","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.975255012512207}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"ORF1a":["L681F"]},"labels":{"aa":"ORF1a: L681F"}}},{"name":"BQ.1.1.60","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.64","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.64"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.916863918304443}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.63","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.371269702911377}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"ORF1b":["V1852I"],"S":["Y248H"]},"labels":{"aa":"ORF1b: V1852I; S: Y248H","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.67","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.67"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.056057929992676}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"ORF1a":["T1881I","T2154I"],"S":["L176F"]},"labels":{"aa":"ORF1a: T1881I, T2154I; S: L176F","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.68"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"ORF1a":["V1211I"]},"labels":{"aa":"ORF1a: V1211I"}}},{"name":"BQ.1.1.66","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.66"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.276078224182129}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.70","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.70"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.841140031814575}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"ORF1a":["A903V"]},"labels":{"aa":"M: S212G; ORF1a: A903V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.73"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.69","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.69"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.636171579360962}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"ORF1b":["S2027L"]},"labels":{"aa":"ORF1b: S2027L"}}},{"name":"BQ.1.1.75","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.75"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"-0.04867000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"1.051732686328446"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.363859176635742}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.76"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.239450931549072}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.77"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"ORF1b":["A1428V"],"S":["Y144-"]},"labels":{"aa":"ORF1b: A1428V; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.731176376342773}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.202805519104004}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.202805519104004}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.70602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"totalAminoacidDeletions":{"value":25},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.662565231323242}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"ORF1a":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"],"S":["G446S"]},"labels":{"aa":"ORF1a: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-; S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0001085","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-07"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.960555553436279}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001086","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-19"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-12"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0001087","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.942427635192871}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.780996322631836}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-02"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.530292510986328}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"ORF1a":["F2864L"],"S":["G181R"]},"labels":{"aa":"ORF1a: F2864L; S: G181R","spike_mutations":"G181R"}}}]},{"name":"NODE_0001088","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.500977516174316}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.409616470336914}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"ORF1a":["A2529T"]},"labels":{"aa":"ORF1a: A2529T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.79"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"ORF1a":["A1812T"],"S":["K147E"]},"labels":{"aa":"ORF1a: A1812T; S: K147E","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-14"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ET.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-16"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0001090","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.65"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ES.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001091","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{"nuc":["C912A"],"ORF1a":["S216Y"]},"labels":{"aa":"ORF1a: S216Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.74371"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8470101435700336"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-30"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.994874000549316}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"ORF1a":["A1809T"],"S":["D339N"]},"labels":{"aa":"ORF1a: A1809T; S: D339N","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452495098114014}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"ORF1b":["D100A"]},"labels":{"aa":"ORF1b: D100A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.72"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.452495098114014}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FC.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918554306030273}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bf35","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.695047378540039}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.74"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.695047378540039}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001094","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"ORF1a":["H374Y","L969F"]},"labels":{"aa":"ORF1a: H374Y, L969F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.212833881378174}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.66913"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9105813557217661"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-24"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"internal_edc4","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"ORF1b":["V1639A"]},"labels":{"aa":"ORF1b: V1639A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8035848140716553}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6774299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9883317000263399"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"CZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001096","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.908818006515503}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.908818006515503}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.810004711151123}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.999442100524902}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"NODE_0001097","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001098","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF1a":["P361S"],"ORF8":["P38S"],"S":["G257S"]},"labels":{"aa":"ORF1a: P361S; ORF8: P38S; S: G257S","spike_mutations":"G257S"}}},{"name":"ER.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ER.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-05"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0001099","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-03"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.548947811126709}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-22"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001100","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001101","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"EN.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-26"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.844334125518799}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0001102","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6486213207244873}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.388934135437012}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.766948223114014}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"ORF1a":["I652V"],"S":["H1083D"]},"labels":{"aa":"ORF1a: I652V; S: H1083D","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.78"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-06-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"ORF1a":["M315I"],"ORF1b":["P1953L"]},"labels":{"aa":"ORF1a: M315I; ORF1b: P1953L"}}}]},{"name":"internal_f9e1","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.134593486785889}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.134593486785889}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.478137016296387}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EA.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.34834999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.880706782961692"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.9221577644348145}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_1117","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504772186279297}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.504772186279297}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FM.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.8300909996032715}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_159a","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.499401330947876}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.499401330947876}},"branch_attrs":{"mutations":{}}},{"name":"ED.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.1880574226379395}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"ORF1a":["D928Y"]},"labels":{"aa":"ORF1a: D928Y"}}},{"name":"ED.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.631465435028076}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF1a":["C433S"],"ORF3a":["L108F"]},"labels":{"aa":"ORF1a: C433S; ORF3a: L108F"}}},{"name":"ED.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"ED.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.897567272186279}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}}]},{"name":"NODE_0001106","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.167686462402344}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0001107","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"ORF1b":["P976S"],"S":["P251L"]},"labels":{"aa":"ORF1b: P976S; S: P251L","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-04"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EH.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002800464630127}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-31"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.002800464630127}},"branch_attrs":{"mutations":{}}},{"name":"DT.1","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.7242"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8884096497350694"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"ORF1a":["S2500F"],"S":["S494P"]},"labels":{"aa":"ORF1a: S2500F; S: S494P","spike_mutations":"S494P"}}},{"name":"DT.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.66091775894165}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DT.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-03"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.224764823913574}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.117682456970215}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.4302685260772705}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0001111","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.492291212081909}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.18422269821167}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.131554126739502}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"ORF1b":["V1538I"]},"labels":{"aa":"ORF1b: V1538I"}}},{"name":"EE.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.522237777709961}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EE.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.840278148651123}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0001113","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.255103588104248}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0001114","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-24"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6288199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8585277476746368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.3","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.65602"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.9455376728168823"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"EW.2","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EW.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"ORF1b":["N2079S"],"S":["A701V"]},"labels":{"aa":"ORF1b: N2079S; S: A701V","spike_mutations":"A701V"}}}]},{"name":"NODE_0001115","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0001116","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-27"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":102,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"FQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-17"},"totalAminoacidSubstitutions":{"value":65},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"ORF1a":["V438I"],"S":["Q613H"]},"labels":{"aa":"ORF1a: V438I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0001117","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.71"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-03"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":103,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.24659999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.9021914619017382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0001118","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.141738414764404}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":94,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.141738414764404}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.3","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.071822166442871}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"EF.2","node_attrs":{"div":95,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.241168022155762}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"ORF1b":["V119I"]},"labels":{"aa":"ORF1b: V119I"}}},{"name":"internal_bc60","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001120","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.138625144958496}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.2","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"EF.1.3","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"internal_e491","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.127105236053467}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001122","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EF.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":100,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"EY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-21"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0001123","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"ORF1a":["V3855I"],"ORF1b":["P2313L"]},"labels":{"aa":"ORF1a: V3855I; ORF1b: P2313L"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":96,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"BQ.1.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-3.6995503902435303}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"ORF1b":["D2351N"]},"labels":{"aa":"ORF1b: D2351N"}}},{"name":"NODE_0001124","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"ORF1a":["V1025L"]},"labels":{"aa":"ORF1a: V1025L"}},"children":[{"name":"DN.3","node_attrs":{"div":97,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.508323669433594}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-05-07"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-7.3331193923950195}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0001125","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":98,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-22"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001126","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"clade_membership":{"value":"22E"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"ORF1a":["R2159W"]},"labels":{"aa":"ORF1a: R2159W"}},"children":[{"name":"DN.1.1","node_attrs":{"div":99,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-25"},"totalAminoacidSubstitutions":{"value":63},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.1","node_attrs":{"div":104,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"2.05606"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8990816968865659"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":66},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"ORF1a":["V721I","N2752S"],"S":["Y453F"]},"labels":{"aa":"ORF1a: V721I, N2752S; S: Y453F","spike_mutations":"Y453F"}}},{"name":"DN.1.1.2","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.5626099999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8771384492554943"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-30"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.6722600000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8744814686582322"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"DN.1.1.3","node_attrs":{"div":101,"clade_display":{"value":"22E (BQ.1)"},"Nextclade_pango":{"value":"DN.1.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22E"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":64},"clade_nextstrain":{"value":"22E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}}]}]}]}]}]}]}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":85,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1467015743255615}},"branch_attrs":{"mutations":{"nuc":["C1627T","A1931C"],"ORF1a":["K556Q"]},"labels":{"aa":"ORF1a: K556Q"}},"children":[{"name":"BA.5.11","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.11"},"totalAminoacidDeletions":{"value":22},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.792257070541382}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF1a":["G82-","H83-","V84-","M85-","V86-"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"]},"labels":{"aa":"ORF1a: G82-, H83-, V84-, M85-, V86-; ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"ORF1a":["R207C","Q3922R"],"S":["A262S"]},"labels":{"aa":"E: S50G; ORF1a: R207C, Q3922R; S: A262S","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001129","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"ORF1b":["T2432I"],"S":["R346T"]},"labels":{"aa":"ORF1b: T2432I; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001130","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"ORF1a":["Q1198R"],"S":["Y144-"]},"labels":{"aa":"ORF1a: Q1198R; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-06"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0001131","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6492786407470703}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":87,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-05-25"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6492786407470703}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001132","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6364240646362305}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6364240646362305}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5279"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.933121919631958}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.076331377029419}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"ORF1b":["H1087Y"],"S":["N450D"]},"labels":{"aa":"ORF1b: H1087Y; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.18","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.087855815887451}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.19","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.17","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.484903812408447}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"ORF1a":["D2880N"]},"labels":{"aa":"ORF1a: D2880N"}}},{"name":"BF.2","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4420108795166016}},"branch_attrs":{"mutations":{"nuc":["T6979G","G14398T"],"ORF1b":["V311L"]},"labels":{"aa":"ORF1b: V311L"}}},{"name":"BF.28","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.100374221801758}},"branch_attrs":{"mutations":{"nuc":["A396T","T6979G"],"ORF1a":["Q44L"]},"labels":{"aa":"ORF1a: Q44L"}}},{"name":"BF.30","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C12789T","C14599T","G22599C","C25916T"],"ORF1a":["T1022I","T4175I"],"ORF3a":["T175I"],"S":["R346T"]},"labels":{"aa":"ORF1a: T1022I, T4175I; ORF3a: T175I; S: R346T","spike_mutations":"R346T"}}},{"name":"BF.33","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6034899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"ORF1b":["N782S","T2432I"],"S":["R346I","N460K"]},"labels":{"aa":"ORF1b: N782S, T2432I; S: R346I, N460K","spike_mutations":"R346I, N460K"}}},{"name":"BF.35","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","C12789T","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF1a":["L730R","T4175I"],"ORF1b":["M557I"],"ORF7a":["T14I"],"S":["N450D"]},"labels":{"aa":"ORF1a: L730R, T4175I; ORF1b: M557I; ORF7a: T14I; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.36","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8252875804901123}},"branch_attrs":{"mutations":{"nuc":["A761G","T6979G","C17285T","C17750T"],"ORF1a":["S166G"],"ORF1b":["S1273L","A1428V"]},"labels":{"aa":"ORF1a: S166G; ORF1b: S1273L, A1428V"}}},{"name":"BF.4","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5455124378204346}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-14"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.914348602294922}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4831809997558594}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"BF.9","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4603519439697266}},"branch_attrs":{"mutations":{"nuc":["G5555A","T6979G","G9220A","G11053C","C16859T","C21727T","C28651T"],"ORF1a":["G1764S","Q3596H"],"ORF1b":["A1131V"]},"labels":{"aa":"ORF1a: G1764S, Q3596H; ORF1b: A1131V"}}},{"name":"NODE_0001133","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4077556133270264}},"branch_attrs":{"mutations":{"nuc":["T4690C","T6979G","G21520T","C22879T"],"ORF1b":["V2685F"]},"labels":{"aa":"ORF1b: V2685F"}},"children":[{"name":"BF.1","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-02"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4077556133270264}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"ORF1a":["E87D","Y925H","D983G","V3524I","V3858L"]},"labels":{"aa":"ORF1a: E87D, Y925H, D983G, V3524I, V3858L"}}}]},{"name":"NODE_0001134","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.132326364517212}},"branch_attrs":{"mutations":{"nuc":["T6979G","C17339T","C28310T"],"N":["L13F"],"ORF1b":["A1291V"]},"labels":{"aa":"N: L13F; ORF1b: A1291V"}},"children":[{"name":"BF.10","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.132326364517212}},"branch_attrs":{"mutations":{}}},{"name":"BF.10.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.10.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.3218"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.563032084337257"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}}]},{"name":"NODE_0001135","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1162216663360596}},"branch_attrs":{"mutations":{"nuc":["T6979G","C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.380282402038574}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.539719581604004}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"ORF1a":["T2274N"]},"labels":{"aa":"ORF1a: T2274N"}}}]},{"name":"NODE_0001136","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4314894676208496}},"branch_attrs":{"mutations":{"nuc":["T6979G","C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF1a":["T224I","L642F","D935G"],"ORF3a":["T175I"]},"labels":{"aa":"ORF1a: T224I, L642F, D935G; ORF3a: T175I"}}},{"name":"BF.27","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3808767795562744}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"ORF1a":["A2784V"]},"labels":{"aa":"ORF1a: A2784V"}}}]},{"name":"NODE_0001137","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.251821517944336}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":51},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.251821517944336}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.31.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.985884428024292}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.33263"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5959379308450252"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.378326892852783}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"ORF1b":["R1078L"],"S":["V445A","N450D"]},"labels":{"aa":"ORF1b: R1078L; S: V445A, N450D","spike_mutations":"V445A, N450D"}}},{"name":"BF.39","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.985884428024292}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a7a7","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112126350402832}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112126350402832}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.41.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"ORF1a":["A138V","V3560I"],"S":["R346T"]},"labels":{"aa":"ORF1a: A138V, V3560I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001140","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-25"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5765063762664795}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11.4","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.462851047515869}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"BF.11.5","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF1a":["S531G"],"ORF8":["I121N"]},"labels":{"aa":"ORF1a: S531G; ORF8: I121N"}}},{"name":"NODE_0001141","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.165992736816406}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.292901039123535}},"branch_attrs":{"mutations":{"nuc":["C629T"],"ORF1a":["L122F"]},"labels":{"aa":"ORF1a: L122F"}}},{"name":"BF.11.2","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.11.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"ORF1a":["T2068P"],"S":["K147N"]},"labels":{"aa":"ORF1a: T2068P; S: K147N","spike_mutations":"K147N"}}}]}]},{"name":"NODE_0001142","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.430593729019165}},"branch_attrs":{"mutations":{"nuc":["A3859G","T6979G"]}},"children":[{"name":"BF.16","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-23"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36989164352417}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.13","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7805731296539307}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"ORF1a":["K2589R"],"ORF1b":["K1957R"],"S":["R346S"]},"labels":{"aa":"ORF1a: K2589R; ORF1b: K1957R; S: R346S","spike_mutations":"R346S"}}},{"name":"BF.22","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-31"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5231502056121826}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.734994888305664}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.34"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-08"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"internal_3b8c","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6532351970672607}},"branch_attrs":{"mutations":{"nuc":["T6979G","G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.735113620758057}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"ORF1a":["L1507F"]},"labels":{"aa":"ORF1a: L1507F"}}},{"name":"internal_faef","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.314535617828369}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.314535617828369}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.3.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.48889999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-27"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.2785773277282715}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"NODE_0001145","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.552170276641846}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6700541973114014}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"ORF1a":["G638C"]},"labels":{"aa":"ORF1a: G638C"}}},{"name":"NODE_0001146","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160181045532227}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.160181045532227}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001147","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.755500316619873}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-24"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0001148","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.070246458053589}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"ORF1a":["I2873V"]},"labels":{"aa":"ORF1a: I2873V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.266221046447754}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001149","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.60558819770813}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-10"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"ORF1a":["K3839R"]},"labels":{"aa":"ORF1a: K3839R"}}},{"name":"NODE_0001150","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.3","node_attrs":{"div":116,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-08"},"totalAminoacidSubstitutions":{"value":62},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF1a":["I567T","G1152S","K2533R","T4217I"],"ORF1b":["V965I","H2571Y"],"ORF3a":["P104S"]},"labels":{"aa":"ORF1a: I567T, G1152S, K2533R, T4217I; ORF1b: V965I, H2571Y; ORF3a: P104S"}}},{"name":"BF.5.2","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.5.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-27"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.603853225708008}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF7b:14-44"},"partiallyAliased":{"value":"BA.5.2.1.42"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-04-11"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF1a":["T265I","T568I","A2587V"],"ORF1b":["P1427L","K2557R"],"ORF7b":["F13-"],"ORF8":["I39V"]},"labels":{"aa":"ORF1a: T265I, T568I, A2587V; ORF1b: P1427L, K2557R; ORF7b: F13-; ORF8: I39V"}}},{"name":"internal_928a","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.39715313911438}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"ORF1b":["G376S"]},"labels":{"aa":"ORF1b: G376S"}}},{"name":"BF.32","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257153511047363}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"ORF1a":["T1552N"],"ORF1b":["G662S"],"S":["N450D"]},"labels":{"aa":"ORF1a: T1552N; ORF1b: G662S; S: N450D","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.416705131530762}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"ORF1a":["S944L"],"S":["G446D"]},"labels":{"aa":"ORF1a: S944L; S: G446D","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.2871978282928467}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238437175750732}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.238437175750732}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.085692405700684}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.38.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"ORF1b":["H604Y"],"S":["V445A"]},"labels":{"aa":"ORF1b: H604Y; S: V445A","spike_mutations":"V445A"}}},{"name":"BF.38.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.38.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:122"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}}]},{"name":"NODE_0001154","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.84029483795166}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-16"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.84029483795166}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-05"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.10","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.12","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.11","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.15","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.15"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"ORF1a":["A1812V"],"S":["G257D"]},"labels":{"aa":"ORF1a: A1812V; S: G257D","spike_mutations":"G257D"}}},{"name":"BF.7.17","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.17"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"ORF1a":["A1485V"],"ORF1b":["I1074V"],"S":["A688V","G1167S"]},"labels":{"aa":"ORF1a: A1485V; ORF1b: I1074V; S: A688V, G1167S","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.18","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6393200000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9261085987091064}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.23","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.092196464538574}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"ORF1b":["T239I"]},"labels":{"aa":"ORF1b: T239I"}}},{"name":"BF.7.21","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.24","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-14"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.26","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.6","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.8","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.7","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.9","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0001155","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"ORF1a":["A498V"]},"labels":{"aa":"ORF1a: A498V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.16.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"ORF1a":["A2123V"],"S":["A688V"]},"labels":{"aa":"ORF1a: A2123V; S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001156","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.19.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0001157","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"ORF1b":["P1427L"]},"labels":{"aa":"ORF1b: P1427L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"ORF1a":["H712N"],"S":["Y144-","G181V"]},"labels":{"aa":"M: H155Y; ORF1a: H712N; S: Y144-, G181V","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.749448776245117}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001158","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"ORF1a":["H388Y","H1160Y"]},"labels":{"aa":"ORF1a: H388Y, H1160Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.13.2","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.13.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}}]},{"name":"NODE_0001159","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.4.3","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-10"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF1a":["I473T"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"]},"labels":{"aa":"N: A90S; ORF1a: I473T; ORF7a: H47N; ORF9b: E86D; S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0001160","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-31"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3122615814208984}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"ORF1b":["P1427S"]},"labels":{"aa":"ORF1b: P1427S"}}},{"name":"BF.7.4.2","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.4.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"ORF1a":["S2024L"],"ORF1b":["S1745T"]},"labels":{"aa":"ORF1a: S2024L; ORF1b: S1745T"}}}]}]},{"name":"NODE_0001161","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF1b":["L238F"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF1b: L238F; ORF7a: H47Y"}},"children":[{"name":"BF.7.27","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0001162","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"ORF1a":["V274L"],"S":["C1243F"]},"labels":{"aa":"ORF1a: V274L; S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-25"},"totalAminoacidSubstitutions":{"value":61},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.444378852844238}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"ORF1a":["I1203V","K2901T"]},"labels":{"aa":"ORF1a: I1203V, K2901T"}}},{"name":"BF.7.14.4","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"ORF1a":["T1844I"]},"labels":{"aa":"ORF1a: T1844I"}}},{"name":"BF.7.14.7","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-24"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"BF.7.14.5","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.325514316558838}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"NODE_0001163","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.3","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.2","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":60},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.6","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BF.7.14.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0001164","node_attrs":{"div":88,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.6319823265075684}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.23"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.23"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8151323795318604}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":89,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-01"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.182566165924072}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.40"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.40"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"ORF1a":["G295C"],"ORF1b":["D2067Y"],"S":["L5F","N450D"]},"labels":{"aa":"ORF1a: G295C; ORF1b: D2067Y; S: L5F, N450D","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-07-22"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"ORF1a":["C1114F","P1213L","A3730V"]},"labels":{"aa":"ORF1a: C1114F, P1213L, A3730V"}}},{"name":"BA.5.2.9","node_attrs":{"div":90,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.9"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.9"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-2.9923171997070312}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"ORF1b":["Y512C"]},"labels":{"aa":"ORF1b: Y512C"}}},{"name":"NODE_0001165","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-1.9059104919433594}},"branch_attrs":{"mutations":{"nuc":["C16616A","C27012T","C27513T"],"ORF1b":["T1050N"]},"labels":{"aa":"ORF1b: T1050N"}},"children":[{"name":"BA.5.2.12","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.12"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.12"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.3895606994628906}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.13"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.13"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6929638385772705}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"ORF1a":["I4291V"],"S":["R346T"]},"labels":{"aa":"ORF1a: I4291V; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.14","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.14"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.14"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-06"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"ORF1a":["T2152I"],"S":["W64L","K444M"]},"labels":{"aa":"ORF1a: T2152I; S: W64L, K444M","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.19","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.19"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.19"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7767930030822754}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.22","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.22"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.22"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-20"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4965717792510986}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"ORF1a":["T1022I"]},"labels":{"aa":"ORF1a: T1022I"}}},{"name":"BA.5.2.28","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.28"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.28"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.1461098194122314}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"ORF1a":["T1437I"]},"labels":{"aa":"ORF1a: T1437I"}}},{"name":"BA.5.2.30","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.30"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.30"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.523481845855713}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.29","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.29"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.29"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.456769943237305}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"ORF1b":["T17I"]},"labels":{"aa":"ORF1b: T17I"}}},{"name":"BA.5.2.34","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.34"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.34"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.511476755142212}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"ORF1b":["V1538L"],"S":["R346T"]},"labels":{"aa":"ORF1b: V1538L; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.35"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.35"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.6543283462524414}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.37"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.37"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.394333839416504}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.39"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.39"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.42"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.42"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"ORF1a":["A2249V","L3829F"],"ORF1b":["S1182L"],"S":["K444T","L981I"]},"labels":{"aa":"ORF1a: A2249V, L3829F; ORF1b: S1182L; S: K444T, L981I","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.44","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.44"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.44"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.278106212615967}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"ORF1a":["L2564F"]},"labels":{"aa":"ORF1a: L2564F"}}},{"name":"BA.5.2.43","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.43"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5642800000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.43"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5413273873731987"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-26"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9836478233337402}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"ORF1a":["A1679V"],"S":["G446D","N460K"]},"labels":{"aa":"ORF1a: A1679V; S: G446D, N460K","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.46","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.46"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.66401"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.46"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.212985038757324}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"ORF1a":["K510E"],"S":["K444T","N460K"]},"labels":{"aa":"ORF1a: K510E; S: K444T, N460K","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.45","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.45"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5131699999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.45"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998797416687012}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.54","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.54"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.54"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.171896934509277}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.52","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.52"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.52"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.112395763397217}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"ORF1a":["D2060N"],"S":["N450D"]},"labels":{"aa":"ORF1a: D2060N; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.55"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.55"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.987527847290039}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.53","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.53"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.53"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.224037170410156}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.57","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.57"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.57"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.694659471511841}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.58","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.58"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5513799999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.58"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.236799716949463}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.61","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.61"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.61"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.711515426635742}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"ORF1b":["Q2070L"],"S":["N450D"]},"labels":{"aa":"ORF1b: Q2070L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.63","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.63"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.63"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-14"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF1a":["A776V","T1794I"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"]},"labels":{"aa":"ORF1a: A776V, T1794I; ORF6: Y31C; S: Y144-, K444N, N460K","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.59","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.59"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.59"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.1926188468933105}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.5.2.62","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.62"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.62"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162878036499023}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.8","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.9392523765563965}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"ORF1a":["L2869F"]},"labels":{"aa":"ORF1a: L2869F"}}},{"name":"internal_236a","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.285115718841553}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.11"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.11"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.216363906860352}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.32"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.32"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.365017890930176}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782564401626587}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"ORF1a":["I2332V"]},"labels":{"aa":"ORF1a: I2332V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.27"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.782564401626587}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CF.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.27.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796359539031982}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"NODE_0001168","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.33"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.934490203857422}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CE.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39901000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.33.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3798828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"internal_1651","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162424087524414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.36"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.162424087524414}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CT.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4564899999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.36.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7208595659836455"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.671617031097412}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.313830852508545}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.38"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.56458"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.30660604695253"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.313830852508545}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DA.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6759999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.38.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4998596931256571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-03"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.4733147621154785}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001171","node_attrs":{"div":91,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.41"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.41"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.635266304016113}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"ORF1a":["S2797F"],"S":["K444R"]},"labels":{"aa":"ORF1a: S2797F; S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.56"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.56"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.025681972503662}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.47"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.3281989097595215}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DQ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.47.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-01"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0001173","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0985677242279053}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.20"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.0985677242279053}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.852132320404053}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BV.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.20.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-23"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.277458667755127}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"internal_d5b0","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4673573970794678}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.21"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-18"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.4673573970794678}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-12"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CN.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.21.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-15"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"ORF1a":["K120N"]},"labels":{"aa":"ORF1a: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.593428373336792}},"branch_attrs":{"mutations":{}}},{"name":"BZ.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-21"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"ORF1a":["S17N"],"ORF1b":["E1288D"],"S":["Q677H"]},"labels":{"aa":"ORF1a: S17N; ORF1b: E1288D; S: Q677H","spike_mutations":"Q677H"}}},{"name":"BZ.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.3.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"ORF1a":["H2794Y"],"S":["N450D"]},"labels":{"aa":"ORF1a: H2794Y; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_74ef","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.31"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.127163410186768}},"branch_attrs":{"mutations":{}}},{"name":"CD.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.35979999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4365416773857803"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.5325236320495605}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}},{"name":"CD.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CD.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5594199999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.31.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3253063676642168"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-30"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"ORF1a":["A2098V"],"S":["A435S"]},"labels":{"aa":"N: D144N; ORF1a: A2098V; S: A435S","spike_mutations":"A435S"}}}]},{"name":"NODE_0001177","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"ORF1b":["S997P"],"S":["T883I"]},"labels":{"aa":"ORF1b: S997P; S: T883I","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.49"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.679863452911377}},"branch_attrs":{"mutations":{}}},{"name":"DZ.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"ORF1a":["L3667F"],"S":["D1146Y"]},"labels":{"aa":"ORF1a: L3667F; S: D1146Y","spike_mutations":"D1146Y"}}},{"name":"DZ.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DZ.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.49.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}}]},{"name":"NODE_0001178","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.059089183807373}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"ORF1b":["P1727L"]},"labels":{"aa":"ORF1b: P1727L"}},"children":[{"name":"BA.5.2.51","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.51"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.51"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.50","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.50"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.50"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-21"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.72301721572876}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"ORF1a":["S2488F"]},"labels":{"aa":"ORF1a: S2488F"}}},{"name":"BA.5.2.60","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.60"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.60"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-12"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.585151672363281}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"ORF1a":["K3832R"],"S":["N450D"]},"labels":{"aa":"ORF1a: K3832R; S: N450D","spike_mutations":"N450D"}}}]},{"name":"NODE_0001179","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"ORF1a":["M598T"],"S":["K444M"]},"labels":{"aa":"ORF1a: M598T; S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.064507484436035}},"branch_attrs":{"mutations":{}}},{"name":"CY.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-01"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.678462505340576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}},{"name":"CY.2","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.7.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-28"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"ORF1a":["I2490S"],"S":["T1066N"]},"labels":{"aa":"N: P20S; ORF1a: I2490S; S: T1066N","spike_mutations":"T1066N"}}}]},{"name":"NODE_0001180","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.246817111968994}},"branch_attrs":{"mutations":{"nuc":["T27012C","T27513C"]}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.10"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.10"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-26"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.743002891540527}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"ORF1a":["M1083I"]},"labels":{"aa":"N: A125T; ORF1a: M1083I"}}},{"name":"BA.5.2.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-06-24"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.62591552734375}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"ORF1b":["G2297S"]},"labels":{"aa":"N: R413S; ORF1b: G2297S"}}},{"name":"NODE_0001181","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8558647632598877}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.26"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-29"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8558647632598877}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.36874999999999986"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.26.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-03"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"ORF1a":["S1520F"],"S":["K444M"]},"labels":{"aa":"ORF1a: S1520F; S: K444M","spike_mutations":"K444M"}}}]}]},{"name":"NODE_0001182","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"ORF1a":["A3697V"]},"labels":{"aa":"ORF1a: A3697V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-14"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.268430233001709}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.57323"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.204470634460449}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"ORF1a":["A3357V"],"S":["Y144-","K444M","N460K"]},"labels":{"aa":"ORF1a: A3357V; S: Y144-, K444M, N460K","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.16"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.39120999999999995"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.48835193087700773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-15"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BU.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.4997300000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.16.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.40917808092175934"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"ORF1a":["I1232T"],"S":["K147N","N450D"]},"labels":{"aa":"ORF1a: I1232T; S: K147N, N450D","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.25"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-25"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.415277004241943}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.356487274169922}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45952999999999994"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-04"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.672739028930664}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DB.3","node_attrs":{"div":107,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DB.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.77543"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.25.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-23"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"ORF1a":["A690V"],"ORF1b":["M2025I"],"S":["Y144-","R346T","N460K"]},"labels":{"aa":"ORF1a: A690V; ORF1b: M2025I; S: Y144-, R346T, N460K","spike_mutations":"Y144-, R346T, N460K"}}}]},{"name":"NODE_0001185","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.18"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-17"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.0179314613342285}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.45785000000000003"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.905637264251709}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"internal_f379","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.66318941116333}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.66318941116333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001187","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.36233377456665}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"ORF1a":["T1001I"],"S":["V62I"]},"labels":{"aa":"ORF1a: T1001I; S: V62I","spike_mutations":"V62I"}}},{"name":"CR.1.3","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5692699999999998"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7114855353996671"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-16"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"ORF1a":["D2592G"],"S":["H146Q"]},"labels":{"aa":"ORF1a: D2592G; S: H146Q","spike_mutations":"H146Q"}}},{"name":"CR.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CR.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40216999999999997"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.7986669946614685"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-05"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"ORF1a":["S443F"],"S":["V445A"]},"labels":{"aa":"N: D377Y; ORF1a: S443F; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"NODE_0001188","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-06"},"totalAminoacidSubstitutions":{"value":52},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.029590129852295}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7050411701202393}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"ORF1b":["T2432I"]},"labels":{"aa":"ORF1b: T2432I"}}},{"name":"NODE_0001189","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.48"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.8912155628204346}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.5254945755004883}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-02-19"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.7626352310180664}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"ORF1a":["T1788M"]},"labels":{"aa":"ORF1a: T1788M"}}}]},{"name":"NODE_0001190","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-31"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"ORF1a":["M315V"],"ORF1b":["T1637I"],"S":["K147E"]},"labels":{"aa":"ORF1a: M315V; ORF1b: T1637I; S: K147E","spike_mutations":"K147E"}}},{"name":"DY.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DY.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5583100000000001"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.48.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.3000370340658239"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-28"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.106734752655029}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_7385","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.201568603515625}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-08-21"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-3.201568603515625}},"branch_attrs":{"mutations":{}}},{"name":"CP.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.38661"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5998825593744821"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.82891845703125}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"ORF1a":["K3353R"],"S":["N460Y"]},"labels":{"aa":"ORF1a: K3353R; S: N460Y","spike_mutations":"N460Y"}}},{"name":"CP.4","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.4"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.628321170806885}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.2","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6942999999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.5295255377787571"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.206088066101074}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"ORF1b":["A520T"],"S":["Y144-","N334K"]},"labels":{"aa":"ORF1b: A520T; S: Y144-, N334K","spike_mutations":"Y144-, N334K"}}},{"name":"CP.5","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.5"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.973639488220215}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.7","node_attrs":{"div":101,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.7"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.7"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-02"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF1a":["Y182H"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"]},"labels":{"aa":"E: I9T; ORF1a: Y182H; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y","spike_mutations":"N703Y"}}},{"name":"CP.6","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.6"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.6"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.885843276977539}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"internal_7ebe","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"ORF1b":["D1939G"]},"labels":{"aa":"ORF1b: D1939G"}},"children":[{"name":"CP.8","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-19"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":102,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.8.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-03-23"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"ORF1a":["P959S","A1997V","V2133I"],"ORF1b":["L1701I"],"S":["P812R"]},"labels":{"aa":"ORF1a: P959S, A1997V, V2133I; ORF1b: L1701I; S: P812R","spike_mutations":"P812R"}}}]},{"name":"NODE_0001193","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.432094573974609}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.1","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.5026299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6938954632982287"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-13"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.384389877319336}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6697299999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.4933085602270773"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.319447994232178}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"ORF1a":["S2114F"],"S":["K150N"]},"labels":{"aa":"ORF1a: S2114F; S: K150N","spike_mutations":"K150N"}}},{"name":"CP.1.3","node_attrs":{"div":96,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CP.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.6003199999999999"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"frameShifts":{"value":"ORF8:117-122"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"totalAminoacidDeletions":{"value":16},"immune_escape":{"value":"0.6214095378573192"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-02"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.222529888153076}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"ORF1a":["A3697V"],"S":["Y144-","G446S"]},"labels":{"aa":"ORF1a: A3697V; S: Y144-, G446S","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"NODE_0001194","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047609329223633}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":92,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"BA.5.2.24"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-09-22"},"totalAminoacidSubstitutions":{"value":53},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.047609329223633}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.3"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-14"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.240954875946045}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.40293000000000007"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.5608456933344607"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.5832133293151855}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.374807834625244}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.374807834625244}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001197","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"ORF1a":["V710I","G3578D"],"S":["S255F"]},"labels":{"aa":"ORF1a: V710I, G3578D; S: S255F","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":99,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.2.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-20"},"totalAminoacidSubstitutions":{"value":58},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":100,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"DG.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-11-09"},"totalAminoacidSubstitutions":{"value":59},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0001198","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.068063735961914}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":93,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-10-11"},"totalAminoacidSubstitutions":{"value":54},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.068063735961914}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0001199","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.98232364654541}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.2","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.71883"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"totalAminoacidDeletions":{"value":14},"immune_escape":{"value":"0.8399353043011233"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-01-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.998134136199951}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"ORF1a":["S2797F"],"S":["-144Y","R346T"]},"labels":{"aa":"ORF1a: S2797F; S: -144Y, R346T","spike_mutations":"-144Y, R346T"}}},{"name":"CK.1.3","node_attrs":{"div":95,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.3"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.711119651794434}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]},{"name":"NODE_0001200","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.607345104217529}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.4","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.4"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}},{"name":"CK.1.5","node_attrs":{"div":97,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.5"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"ORF1a":["M3733V"]},"labels":{"aa":"ORF1a: M3733V"}}}]},{"name":"NODE_0001201","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"clade_membership":{"value":"22B"},"clade_who":{"value":"Omicron"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-07-09"},"totalAminoacidSubstitutions":{"value":57},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"ORF1a":["T1788M"],"S":["E654K"]},"labels":{"aa":"ORF1a: T1788M; S: E654K","spike_mutations":"E654K"}}},{"name":"CK.1.1","node_attrs":{"div":94,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2022-12-29"},"totalAminoacidSubstitutions":{"value":55},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-5.021605491638184}},"branch_attrs":{"mutations":{}}},{"name":"CK.1.1.2","node_attrs":{"div":98,"clade_display":{"value":"22B (BA.5)"},"Nextclade_pango":{"value":"CK.1.1.2"},"designation_recency":{"value":">8 weeks"},"qc.overallScore":{"value":0.0},"clade_membership":{"value":"22B"},"ace2_binding":{"value":"0.60741"},"clade_who":{"value":"Omicron"},"qc.frameShifts.totalFrameShifts":{"value":0},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"totalAminoacidDeletions":{"value":15},"immune_escape":{"value":"0.6765077176301588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_date":{"value":"2023-09-10"},"totalAminoacidSubstitutions":{"value":56},"clade_nextstrain":{"value":"22B"},"placement_prior":{"value":-4.657632350921631}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA*","ORF1a":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLN","ORF1b":"RVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json b/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json index 4024c152..681a0bb7 100644 --- a/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json +++ b/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json @@ -1 +1 @@ -{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-25","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/proteins/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/proteins/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/proteins/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF10":{"end":29674,"seqid":"profiles/clades/proteins/reference_seq.gb","start":29558,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/proteins/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/proteins/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/proteins/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nsp1":{"end":805,"seqid":"profiles/clades/proteins/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"nsp10":{"end":13441,"seqid":"profiles/clades/proteins/reference_seq.gb","start":13025,"strand":"+","type":"CDS"},"nsp11":{"end":13480,"seqid":"profiles/clades/proteins/reference_seq.gb","start":13442,"strand":"+","type":"CDS"},"nsp12":{"seqid":"profiles/clades/proteins/reference_seq.gb","strand":"+","type":"CDS","segments":[{"start":13442,"end":13468},{"start":13468,"end":16236}]},"nsp13":{"end":18039,"seqid":"profiles/clades/proteins/reference_seq.gb","start":16237,"strand":"+","type":"CDS"},"nsp14":{"end":19620,"seqid":"profiles/clades/proteins/reference_seq.gb","start":18040,"strand":"+","type":"CDS"},"nsp15":{"end":20658,"seqid":"profiles/clades/proteins/reference_seq.gb","start":19621,"strand":"+","type":"CDS"},"nsp16":{"end":21552,"seqid":"profiles/clades/proteins/reference_seq.gb","start":20659,"strand":"+","type":"CDS"},"nsp2":{"end":2719,"seqid":"profiles/clades/proteins/reference_seq.gb","start":806,"strand":"+","type":"CDS"},"nsp3":{"end":8554,"seqid":"profiles/clades/proteins/reference_seq.gb","start":2720,"strand":"+","type":"CDS"},"nsp4":{"end":10054,"seqid":"profiles/clades/proteins/reference_seq.gb","start":8555,"strand":"+","type":"CDS"},"nsp5":{"end":10972,"seqid":"profiles/clades/proteins/reference_seq.gb","start":10055,"strand":"+","type":"CDS"},"nsp6":{"end":11842,"seqid":"profiles/clades/proteins/reference_seq.gb","start":10973,"strand":"+","type":"CDS"},"nsp7":{"end":12091,"seqid":"profiles/clades/proteins/reference_seq.gb","start":11843,"strand":"+","type":"CDS"},"nsp8":{"end":12685,"seqid":"profiles/clades/proteins/reference_seq.gb","start":12092,"strand":"+","type":"CDS"},"nsp9":{"end":13024,"seqid":"profiles/clades/proteins/reference_seq.gb","start":12686,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-02-18","#531EA6"],["2021-02-21","#521EA7"],["2021-03-02","#4E20AC"],["2021-03-10","#4C24AF"],["2021-03-15","#4B26B1"],["2021-04-01","#472DB8"],["2021-04-07","#462FBA"],["2021-04-08","#4530BB"],["2021-04-13","#4432BD"],["2021-04-19","#4334BF"],["2021-04-20","#4335C0"],["2021-04-21","#4235C0"],["2021-04-23","#4236C1"],["2021-04-26","#4137C2"],["2021-04-30","#4039C4"],["2021-05-05","#403BC5"],["2021-05-13","#4040C6"],["2021-05-16","#4041C7"],["2021-05-21","#3F44C8"],["2021-05-25","#3F46C8"],["2021-05-26","#3F46C9"],["2021-06-04","#3F4BCA"],["2021-06-14","#3F50CC"],["2021-06-18","#3F53CD"],["2021-06-19","#3F53CD"],["2021-06-25","#3F56CE"],["2021-06-30","#3E59CF"],["2021-07-01","#3E59CF"],["2021-07-13","#3F5FD0"],["2021-07-22","#4064CF"],["2021-07-23","#4064CF"],["2021-07-26","#4066CF"],["2021-07-27","#4066CF"],["2021-07-28","#4067CF"],["2021-07-30","#4068CF"],["2021-08-02","#4169CF"],["2021-08-03","#416ACF"],["2021-08-04","#416ACF"],["2021-08-07","#416CCE"],["2021-08-09","#416DCE"],["2021-08-10","#416DCE"],["2021-08-12","#416ECE"],["2021-08-13","#416FCE"],["2021-08-16","#4270CE"],["2021-08-17","#4271CE"],["2021-08-18","#4271CE"],["2021-08-19","#4271CE"],["2021-08-22","#4273CE"],["2021-08-25","#4374CD"],["2021-08-27","#4375CD"],["2021-09-02","#4378CD"],["2021-09-03","#4379CD"],["2021-09-13","#447DCC"],["2021-09-20","#4580CA"],["2021-09-23","#4681C9"],["2021-09-24","#4682C9"],["2021-09-27","#4783C8"],["2021-09-29","#4783C8"],["2021-09-30","#4784C8"],["2021-10-04","#4885C7"],["2021-10-08","#4887C6"],["2021-10-11","#4988C5"],["2021-10-12","#4988C5"],["2021-10-18","#4A8BC3"],["2021-10-22","#4A8CC2"],["2021-10-25","#4B8DC2"],["2021-10-27","#4B8EC1"],["2021-10-28","#4B8FC1"],["2021-11-02","#4C91C0"],["2021-11-04","#4C91BF"],["2021-11-05","#4D92BF"],["2021-11-17","#4F96BC"],["2021-11-18","#4F96BB"],["2021-11-19","#4F97BB"],["2021-11-23","#5098BA"],["2021-11-24","#5098B9"],["2021-11-25","#5098B9"],["2021-11-29","#5199B7"],["2021-12-03","#529AB6"],["2021-12-07","#539BB4"],["2021-12-08","#539CB4"],["2021-12-10","#539CB3"],["2021-12-13","#549DB2"],["2021-12-14","#549DB2"],["2021-12-17","#559EB1"],["2021-12-19","#559FB0"],["2021-12-21","#569FAF"],["2021-12-22","#56A0AF"],["2021-12-26","#57A1AE"],["2021-12-28","#57A1AD"],["2022-01-01","#58A2AB"],["2022-01-05","#59A3AA"],["2022-01-07","#59A4A9"],["2022-02-16","#63AC99"],["2022-02-23","#65AD96"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-29","#6FB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-21","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Beta","#4067CF"],["Gamma","#4A8BC3"],["Delta","#5AA4A9"],["Epsilon","#6FB488"],["Eta","#8BBB69"],["Theta","#A9BD53"],["Iota","#C7B944"],["Kappa","#DDA93C"],["Lambda","#E68A35"],["Mu","#E35C2C"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","clade_who","clade_display","designation_date","designation_recency"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":true},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":false},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{},"labels":{"clade":"19A"}},"children":[{"name":"B","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{"ORF6":["D61L"],"S":["T19I"]},"labels":{"aa":"ORF6: D61L; S: T19I","spike_mutations":"T19I"}},"children":[{"name":"XAA","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A1610G","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C8247T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12445T","C12880T","C14408T","C15714T","C17410T","A18163G","A19356G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["N269D"],"nsp3":["K38R","S1265-","L1266I","S1843F"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: N269D; nsp3: K38R, S1265-, L1266I, S1843F; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAB","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.443575382232666}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17010T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XA","node_attrs":{"div":33,"Nextclade_pango":{"value":"XA"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T445C","T2019C","C3037T","C4999T","C6286T","C8090T","C9430T","A10323G","C13945T","C14408T","G20410A","G21255C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23208T","C23271A","A23403G","C23604A","C23709T","T24506G","G24914C","G25855T","C27972T","G28048T","A28095T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"N":["D3L","R203K","G204R","S235F"],"ORF3a":["D155Y"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","K68*","Y73C"],"S":["I19T","H69-","V70-","Y144-","N501Y","T549I","A570D","D614G","P681H","T716I","S982A","D1118H"],"nsp12":["P169S","P323L"],"nsp15":["E264K"],"nsp2":["M405T"],"nsp3":["L1791F"],"nsp5":["K90R"]},"labels":{"aa":"N: D3L, R203K, G204R, S235F; ORF3a: D155Y; ORF6: L61D; ORF8: Q27*, R52I, K68*, Y73C; S: I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H; nsp12: P169S, P323L; nsp15: E264K; nsp2: M405T; nsp3: L1791F; nsp5: K90R","spike_mutations":"I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H"}}},{"name":"XAF","node_attrs":{"div":65,"Nextclade_pango":{"value":"XAF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","T181I","V182F"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, T181I, V182F","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAE","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.17270999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","G4975A","A6390C","C9344T","A9424G","C9534T","C9803T","C9866T","C10029T","C10198T","G10447A","C10449A","C11249T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C","T29748C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","E1224A"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["R93C","S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, E1224A; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: R93C, S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAD","node_attrs":{"div":66,"Nextclade_pango":{"value":"XAD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.857146263122559}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","A1250G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["T149A"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: T149A; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.851975917816162}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15720T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25731T","C25810T","C26028T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["L140F"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: L140F; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAJ","node_attrs":{"div":72,"Nextclade_pango":{"value":"XAJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.647030830383301}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11674T","C12880T","C14408T","T15009C","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","A23535G","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N658S","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XAH","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.717092990875244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","G17242T","C17410T","A18163G","C18246T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33G","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["A336S","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33G, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: A336S, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAG","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.28093999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C2857T","C3037T","T5386G","C5585A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C12880T","C14408T","C15714T","C17410T","C17502T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","L956I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, L956I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAK","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15166"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3037714005953052"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4927T","T5386G","C7834T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C12880T","C14408T","C15240T","A18163G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","A22001G","T22200G","G22578A","G22599A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22942G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24863T","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","H69-","V70-","G142D","K147E","V213G","G339D","R346K","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N460K","S477N","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","H1101Y"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y; nsp1: S135R; nsp12: P323L; nsp14: I42V; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y"}}},{"name":"XAL","node_attrs":{"div":61,"Nextclade_pango":{"value":"XAL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","A2865G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","G21586T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L8F","L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","E49G","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, E49G, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K"}}},{"name":"XAM","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75567"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","T181I"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, T181I","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAN","node_attrs":{"div":70,"Nextclade_pango":{"value":"XAN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081246852874756}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7973A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","C17822T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","T27696C","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29666T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["L37F"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C","P529L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","L1752M"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: L37F; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C, P529L; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, L1752M; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAR","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.447500705718994}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21796T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","R78S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAP","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.9306466579437256}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C5407A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAQ","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","C9857T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23779T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAS","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.466667652130127}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAT","node_attrs":{"div":66,"Nextclade_pango":{"value":"XAT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","C10277T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19317T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25810T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["L140F","T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["L75F","P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: L140F, T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: L75F, P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAV","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.716916561126709}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C6606T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15960T","G17278T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["V348L","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","S1296F"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: V348L, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, S1296F; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAW","node_attrs":{"div":96,"Nextclade_pango":{"value":"XAW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91409"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.274687314409391"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C335T","G569A","T689C","G1048T","G1125A","C1973T","C3037T","G3246A","G4181T","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9676C","C10029T","A10323G","A11201G","G11330A","A11332G","C11866T","C13806T","C13994T","C14408T","C14585T","G15451A","C16466T","C17304T","C17550T","A17973G","G18525A","C19220T","C19290T","C20402T","G20493A","C21575T","C21618G","C21636T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","T22942A","G22992A","C22995A","A23013C","T23042C","A23055G","A23063T","T23075C","C23114T","A23403G","C23525T","C23604A","C23854A","G23948T","G24145A","A24424T","T24469A","C25000T","C25584T","A25592G","C26060T","C26270T","C26537T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28562A","G28646A","C28849T","C28873T","G28881T","G28916T","G29402T","C29635T","G29742T"],"E":["T9I"],"M":["Q19E","A63T"],"N":["D63G","G97S","A125T","R203M","G215C","D377Y"],"ORF3a":["K67R","T223I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["L5F","I19R","P25L","E156-","F157-","R158G","N211-","L212I","L242-","A243-","G339D","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","N460K","S477N","T478K","E484A","S494P","Q498R","N501Y","Y505H","D614G","H655Y","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["R24C","E102K","S142P"],"nsp12":["A185V","P323L","A382V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp15":["S261L"],"nsp2":["K81N","R107K"],"nsp3":["S176N","A488S","P778L","D1144N","P1228L","P1469S","A1570T"],"nsp4":["V167L","T492I"],"nsp5":["K90R"],"nsp6":["T77A","V120M"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: D63G, G97S, A125T, R203M, G215C, D377Y; ORF3a: K67R, T223I; ORF8: D119-, F120-; ORF9b: T60A; S: L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K; nsp1: R24C, E102K, S142P; nsp12: A185V, P323L, A382V, G671S; nsp13: P77L; nsp14: A394V; nsp15: S261L; nsp2: K81N, R107K; nsp3: S176N, A488S, P778L, D1144N, P1228L, P1469S, A1570T; nsp4: V167L, T492I; nsp5: K90R; nsp6: T77A, V120M","spike_mutations":"L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAU","node_attrs":{"div":70,"Nextclade_pango":{"value":"XAU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.173168659210205}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","T17407C","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAZ","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1912T","C2232T","C2790T","C3037T","C3317T","T3358C","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A476V"],"nsp3":["T24I","P200S","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A476V; nsp3: T24I, P200S, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XB","node_attrs":{"div":29,"Nextclade_pango":{"value":"XB"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-11-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.699317693710327}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C3688T","C3884T","C6633T","A7142G","A9614G","C9693T","A9754C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14408T","G15451A","C16466T","C21057T","T21615G","C21846T","A22036C","A23403G","C23604A","C23625T","T23765G","C24442T","C24642T","G26158-","T26159-","T26160-","A26161-","C26222T","C27389T","C27769T","G28048A","A28271-","A28330G","C28854T","A28910T"],"N":["S194L","N213Y"],"ORF3a":["V256-","N257-","P258I","M260I","E261I","P262I","T269I","P274I","L275I"],"ORF6":["L61D"],"ORF7b":["S5L"],"ORF8":["R52K"],"ORF9b":["D16G"],"S":["L18R","I19T","T95I","R158S","D614G","P681H","A688V","S735A","T1027I"],"nsp12":["P323L","G671S"],"nsp13":["P77L"],"nsp3":["P389S","A1305V","S1475G"],"nsp4":["T354A","A380V","R400S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: S194L, N213Y; ORF3a: V256-, N257-, P258I, M260I, E261I, P262I, T269I, P274I, L275I; ORF6: L61D; ORF7b: S5L; ORF8: R52K; ORF9b: D16G; S: L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I; nsp12: P323L, G671S; nsp13: P77L; nsp3: P389S, A1305V, S1475G; nsp4: T354A, A380V, R400S; nsp6: S106-, G107-, F108-","spike_mutations":"L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I"}}},{"name":"XBA","node_attrs":{"div":70,"Nextclade_pango":{"value":"XBA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20215999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.29808642936638835"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4181T","C6402T","C7124T","C8595T","C8986T","G9053T","C10029T","A11201G","A11332G","G13812T","C14408T","C14790T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","A22991G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","T26767C","G26959A","T27638C","A27663T","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","C28311T","A28461G","G28881A","G28882A","G28883C","G29402T","G29742T"],"M":["I82T","R146H"],"N":["P13L","D63G","R203K","G204R","D377Y"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["P10S","T60A"],"S":["L18F","I19R","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477D","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","T1117I"],"nsp1":["S135R"],"nsp12":["M124I","P323L","A529V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["T24I","A488S","P1228L","P1469S"],"nsp4":["T14I","V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T, R146H; N: P13L, D63G, R203K, G204R, D377Y; ORF3a: S26L; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: P10S, T60A; S: L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I; nsp1: S135R; nsp12: M124I, P323L, A529V, G671S; nsp13: P77L; nsp14: A394V; nsp3: T24I, A488S, P1228L, P1469S; nsp4: T14I, V167L, T492I; nsp6: T77A","spike_mutations":"L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I"}}},{"name":"XBD","node_attrs":{"div":82,"Nextclade_pango":{"value":"XBD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBE","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.574315547943115}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27800T","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["T127N","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: T127N, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBH","node_attrs":{"div":80,"Nextclade_pango":{"value":"XBH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.37244999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7528T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13730T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25157A","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28881A","G28882A","G28883C","A29510C","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","T29758C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","D1199N"],"nsp1":["S135R"],"nsp12":["A97V","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N; nsp1: S135R; nsp12: A97V, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N"}}},{"name":"XBG","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10116T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11665T","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","A24676G","C25000T","C25584T","C26060T","T26180C","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I","I263T"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["T21I","P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I, I263T; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: T21I, P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBN","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","A2863G","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","A19459G","C19554T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C25638T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","I474V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, I474V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBM","node_attrs":{"div":74,"Nextclade_pango":{"value":"XBM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","G19891A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23202T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27549T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","T547I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["D91N","T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: D91N, T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBP","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7303T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C12952T","C13965T","C14408T","C15277T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","T23773C","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","H613Y","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, H613Y, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBR","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1093T","G1440A","A1964G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","A5844G","C8597T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21077T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22855T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25471C","C25553T","T25569C","C25584T","G26031A","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["D27H","A54V","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["T140I"],"nsp2":["G212D","I387V"],"nsp3":["T24I","S403L","G489S","P822S","K1042R"],"nsp4":["L15F","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: D27H, A54V, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: T140I; nsp2: G212D, I387V; nsp3: T24I, S403L, G489S, P822S, K1042R; nsp4: L15F, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBQ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G14829T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","M463I","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, M463I, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBS","node_attrs":{"div":82,"Nextclade_pango":{"value":"XBS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T670G","C2790T","C2842T","C3037T","C3796T","C3809T","C3927T","G4184A","C4321T","C4586T","C5183T","C6982T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","T20748C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["G82-","H83-","V84-","M85V","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","L364F","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: G82-, H83-, V84-, M85V, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, L364F, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBT","node_attrs":{"div":81,"Nextclade_pango":{"value":"XBT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64255"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5037920175803539"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C829T","C1627T","C2790T","C3037T","A3207G","G4184A","G4288A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","G23587A","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","D163G","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, D163G, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBV","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32919999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8040G","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","G15957T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123A","A23223G","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24170G","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","P521T","E554G","D614G","H655Y","N679K","P681H","N764K","D796Y","I870V","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["T127N","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","D1774G"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: T127N, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, D1774G; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K"}}},{"name":"XBW","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22612C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","G29260A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBU","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74825"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["A51V","S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: A51V, S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBY","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5812T","C9344T","A9424G","C9532T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","G19962T","A20055G","C21054T","G21305A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T28137A","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["S82T"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["R216H"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: S82T; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: R216H; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XC","node_attrs":{"div":39,"Nextclade_pango":{"value":"XC"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5239T","T5514C","C6402T","C7124T","C8986T","G9053T","C10029T","A11201G","A11332G","C14408T","G15451A","C16466T","C19220T","C21618G","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22081T","T22917G","C22995A","A23403G","C23604G","G24410A","C25469T","T26767C","G27390T","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"M":["I82T"],"N":["D3L","R203K","G204R","S235F"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","Y73C"],"S":["I19R","T95I","G142D","E156-","F157-","R158G","Q173H","L452R","T478K","D614G","P681R","D950N"],"nsp12":["P323L","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["A488S","V932A","P1228L","P1469S"],"nsp4":["V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T; N: D3L, R203K, G204R, S235F; ORF3a: S26L; ORF6: L61D; ORF8: Q27*, R52I, Y73C; S: I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N; nsp12: P323L, G671S; nsp13: P77L; nsp14: A394V; nsp3: A488S, V932A, P1228L, P1469S; nsp4: V167L, T492I; nsp6: T77A","spike_mutations":"I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N"}}},{"name":"XBZ","node_attrs":{"div":80,"Nextclade_pango":{"value":"XBZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","T2954C","C3037T","G4184A","C4321T","C6040T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","C12880T","T14257C","C14408T","C15714T","G16935A","A17039G","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T21992-","A21993-","T21994-","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22858T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23086T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26428T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","C28770T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","V62F"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","T166I","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","Y144-","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["Y273H","P323L"],"nsp13":["M233I","N268S","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, V62F; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, T166I, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: Y273H, P323L; nsp13: M233I, N268S, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCA","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74825"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2062T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C5748A","C9344T","A9424G","T9454C","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19017T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21893A","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","C22747T","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","C23595T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","T25975C","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["S195P","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","D111N","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","T678I","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S","T1010N"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["A51V","S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: S195P, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S, T1010N; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: A51V, S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCC","node_attrs":{"div":97,"Nextclade_pango":{"value":"XCC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1545T","C2790T","C3037T","C3796T","C3857A","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A247V"],"nsp3":["T24I","Q380K","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A247V; nsp3: T24I, Q380K, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCB","node_attrs":{"div":75,"Nextclade_pango":{"value":"XCB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.41968"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","A11126G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C12880T","C14408T","C14724T","C15714T","C17410T","A18163G","G18651A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22302-","T22303-","T22304-","T22348A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27600T","C27807T","C27889T","A28271T","T28282C","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","S247-","Y248N","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["M52V","S106-","G107-","F108-"],"nsp8":["A74T"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: M52V, S106-, G107-, F108-; nsp8: A74T","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCE","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1931A","C2790T","T2954C","C3037T","G4184A","C4321T","C9344T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15810T","T15939C","T16342C","C17410T","T17859C","A18163G","G18811A","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","Y200C","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D258N"],"nsp15":["T112I"],"nsp2":["Q376K"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D258N; nsp15: T112I; nsp2: Q376K; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCD","node_attrs":{"div":91,"Nextclade_pango":{"value":"XCD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95377"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18006C","A18163G","A19173G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22203A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","G28077T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28681T","G28881A","G28882A","G28883C","C29367T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","P365L","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","R214H","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, P365L, S413R; ORF3a: T223I; ORF6: L61D; ORF8: V62L; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCG","node_attrs":{"div":87,"Nextclade_pango":{"value":"XCG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16254"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8170G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCM","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","G331T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","C5730T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T13560C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17661C","T17859C","A18163G","A18879G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24134A","A24373G","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","A29558G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["M1V"],"ORF3a":["A72T","A110V","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","F157L","N185D","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"],"nsp1":["Q22H","K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","T1004I","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: M1V; ORF3a: A72T, A110V, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K; nsp1: Q22H, K47R, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, T1004I, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}}},{"name":"XCL","node_attrs":{"div":101,"Nextclade_pango":{"value":"XCL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C7417T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15755G","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23093A","A23403G","C23525T","T23599G","C23604A","C23741T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25046T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","V511I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","P1162S"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S","S772C"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S; nsp1: K47R, S135R; nsp12: P323L, G671S, S772C; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S"}}},{"name":"XCJ","node_attrs":{"div":97,"Nextclade_pango":{"value":"XCJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C1063T","C2790T","C3037T","G4184A","C4321T","C6312T","A6616G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22843C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27431T","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28770T","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","T166I","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF7a":["A13V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","G181R","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","T1198I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, T166I, R203K, G204R, S413R; ORF3a: T223I; ORF7a: A13V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, T1198I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCK","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","T2128C","C2790T","C3037T","G3242A","G4184A","C4321T","C5512T","G5720A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12880T","C12970T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18096C","A18163G","A19326G","C19955T","G19962T","A20055G","G20060T","A21137G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","C26270T","G26529A","C26577G","G26709A","G26951C","C27807T","C27889T","C28163A","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","T29726-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I","V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I","S147I"],"nsp16":["K160R"],"nsp3":["T24I","G175S","G489S","G1001S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I, V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I, S147I; nsp16: K160R; nsp3: T24I, G175S, G489S, G1001S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XCP","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","C3622T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","C12880T","C14408T","A14634G","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","C19185T","A19326G","C19488T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","I189V"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, I189V; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCR","node_attrs":{"div":106,"Nextclade_pango":{"value":"XCR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C13405T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24373C","A24424T","T24469A","C25000T","A25359G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26708G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K","K1266R"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R"}}},{"name":"XCQ","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","A13187G","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","A22320G","C22388T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23757T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","T732I","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp10":["I55V"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp10: I55V; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K"}}},{"name":"XCN","node_attrs":{"div":116,"Nextclade_pango":{"value":"XCN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C337T","T670G","C1142T","C1471T","C1513T","C1686T","T2372C","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7318T","C8782T","G8849A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C14408T","C14790T","T14961C","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21807A","C21910T","G21987A","A22001G","T22016C","C22033A","A22121G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","T23332C","A23403G","C23453T","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27635T","C27807T","G27915T","C28253T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","P82H","G142D","K147E","W152R","F157L","K187E","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","P631S","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["L113F","A294V"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["V99M","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF7a: S81L; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: L113F, A294V; nsp3: T24I, S403L, G489S, P822S; nsp4: V99M, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCS","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17010T","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27669G","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","A29221G","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K"}}},{"name":"XCV","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","T5422C","C7044A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27065A","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28182G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","P1442H"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, S97G; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, P1442H; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCU","node_attrs":{"div":99,"Nextclade_pango":{"value":"XCU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8835"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1437T","C2790T","C3037T","T3478C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","C9891T","C10029T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","A17207G","A19890G","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","T23042C","A23055G","A23063T","T23075C","C23123A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","C26606T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28376A","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","A35T","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","D215H","A222V","L242-","A243-","S256L","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","S494P","Q498R","N501Y","Y505H","P521T","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["P77L","T127I","Y324C"],"nsp2":["S211F"],"nsp3":["T24I","T725I","P822L","S1286I","G1447S","V1458I","I1683V"],"nsp4":["A446V","T492I"],"nsp6":["V149A","T181I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, A35T, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: P77L, T127I, Y324C; nsp2: S211F; nsp3: T24I, T725I, P822L, S1286I, G1447S, V1458I, I1683V; nsp4: A446V, T492I; nsp6: V149A, T181I","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCY","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCZ","node_attrs":{"div":112,"Nextclade_pango":{"value":"XCZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","A15436G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22609G","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26735T","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28519T","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-","T79I"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","M666V","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-, T79I; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: D63N, P323L, M666V, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XCW","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","T6394C","G6536A","G8863T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T14305C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","G18636A","T18882C","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27513T","C27684T","C27807T","G27915T","T28034C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","I210-","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["Y289H","P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: Y289H, P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDB","node_attrs":{"div":97,"Nextclade_pango":{"value":"XDB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","G15982A","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S","V848I"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S, V848I; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XD","node_attrs":{"div":65,"Nextclade_pango":{"value":"XD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.029110000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.17203353628663032"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","A1321C","C3037T","G4181T","C6402T","C7124T","C7851T","A8723G","C8986T","G9053T","C10029T","A11201G","A11332G","C14407T","C14408T","T15264C","G15451A","C16466T","C19220T","C21618G","G21641T","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25667T","G25855T","T26767C","T27638C","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G28916T","G29402T","G29540A","G29645T","G29742T"],"M":["I82T"],"N":["D63G","R203M","G215C","D377Y"],"ORF10":["V30L"],"ORF3a":["S92L","D155Y"],"ORF6":["L61D"],"ORF7a":["V82A","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["I19R","A27S","T95I","G142D","E156-","F157-","R158G","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323F","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp2":["E172D"],"nsp3":["A488S","P1228L","P1469S","A1711V"],"nsp4":["I57V","V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T; N: D63G, R203M, G215C, D377Y; ORF10: V30L; ORF3a: S92L, D155Y; ORF6: L61D; ORF7a: V82A, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: T60A; S: I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323F, G671S; nsp13: P77L; nsp14: A394V; nsp2: E172D; nsp3: A488S, P1228L, P1469S, A1711V; nsp4: I57V, V167L, T492I; nsp6: T77A","spike_mutations":"I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XDC","node_attrs":{"div":108,"Nextclade_pango":{"value":"XDC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2110T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","C15763T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21036T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: D63N, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDE","node_attrs":{"div":104,"Nextclade_pango":{"value":"XDE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","T21363C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26612G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29535T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["S122F"],"nsp3":["T24I","G489S","P1261Q","T1465I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["P80L"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: S122F; nsp3: T24I, G489S, P1261Q, T1465I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: P80L","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDF","node_attrs":{"div":107,"Nextclade_pango":{"value":"XDF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C335T","A405G","T670G","C2790T","C3037T","T3453C","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","G27666T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","T28382C","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","S37P","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["R24C","K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","V245A","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, S37P, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF7a: E91D; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: R24C, K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, V245A, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDG","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C547T","T670G","C1758T","C2790T","C3037T","G4184A","C4321T","T4579A","T4690C","T4930C","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","T16905C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","A23598G","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","A25744G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28754T","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","L161F","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["I118V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679R","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A318V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, L161F, R203K, G204R, S413R; ORF10: S23F; ORF3a: I118V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A318V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDH","node_attrs":{"div":97,"Nextclade_pango":{"value":"XDH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","T2992A","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","T4744C","C5183T","T7477C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C13335T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp10":["A104V"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","D91E","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp10: A104V; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, D91E, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDJ","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C8947T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","A10861G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G29081T","A29510C","C29625T","A29700G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","V270L","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","F157L","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, V270L, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDM","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","T24046C","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["T85A","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp2":["D155G"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: T85A, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp2: D155G; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDL","node_attrs":{"div":110,"Nextclade_pango":{"value":"XDL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2650T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","C17410T","T17859C","C17976T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","T24903C","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","C28253A","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","F120L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","I1114T"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, F120L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T; nsp1: K47R, S135R; nsp12: D63N, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T"}}},{"name":"XDN","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","C280T","T670G","C897A","C1762A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","C12880T","T13339C","C14408T","C14425T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D","F319L"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D, F319L; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K"}}},{"name":"XDS","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","G598A","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29409T","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","C29836T"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","T379I","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, T379I, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDT","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C1601T","C2790T","C3037T","G3431T","G4184A","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9344T","A9424G","C9534T","C9661T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","T25496C","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27014A","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29778A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["I35T","T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","H69-","V70-","V127F","G142D","Y144-","R158G","N211-","L212I","V213G","L216F","A222V","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D","L266F"],"nsp3":["T24I","V238L","G489S","N1708S","A1892T"],"nsp4":["I27V","L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp7":["V33A"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: I35T, T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D, L266F; nsp3: T24I, V238L, G489S, N1708S, A1892T; nsp4: I27V, L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp7: V33A; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}}},{"name":"XDU","node_attrs":{"div":111,"Nextclade_pango":{"value":"XDU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.63761"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9475349114594978"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","C3177T","C3587T","C3944A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","C22674T","T22679C","C22686T","A22688G","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26078T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I","T229I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","S371F","S373P","S375F","T376A","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","P153L","H290Y","Q409K","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I, T229I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, P153L, H290Y, Q409K, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDY","node_attrs":{"div":127,"Nextclade_pango":{"value":"XDY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","G19669A","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","C22858T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["G17R","T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: G17R, T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15919"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","T1030C","A2127G","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14120T","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21301T","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A263V","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P227L","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["P215S"],"nsp2":["A31D","Y441C"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P227L, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: P215S; nsp2: A31D, Y441C; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XDZ","node_attrs":{"div":114,"Nextclade_pango":{"value":"XDZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7086T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","C23557T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S","T1456I"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S, T1456I; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XE","node_attrs":{"div":62,"Nextclade_pango":{"value":"XE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C14599T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XEB","node_attrs":{"div":119,"Nextclade_pango":{"value":"XEB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEA","node_attrs":{"div":122,"Nextclade_pango":{"value":"XEA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.41162"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2268340125514634"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","C13255T","T13339C","A13712G","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R"],"nsp12":["K91R","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","D695E","K1155R","N1708S","A1711S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R; nsp12: K91R, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, D695E, K1155R, N1708S, A1711S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XED","node_attrs":{"div":124,"Nextclade_pango":{"value":"XED"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":17.361},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XED"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9430T","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","A13308G","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25350T","C25584T","C26060T","C26270T","G26529C","C26577G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L","P1263L"],"nsp1":["S135R","T170I"],"nsp10":["K95R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L; nsp1: S135R, T170I; nsp10: K95R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L"}}},{"name":"XEG","node_attrs":{"div":119,"Nextclade_pango":{"value":"XEG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":950.694},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","A2443G","C2790T","C2939T","C3037T","C3876T","G4184A","C4234T","C4321T","G6536A","A6646G","T6747C","C7819G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T10723C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","G19327T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","C23191T","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V","A430S"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","P74S","A386V","G489S","G1273S","L1343S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V, A430S; nsp15: T112I; nsp2: A31D; nsp3: T24I, P74S, A386V, G489S, G1273S, L1343S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEE","node_attrs":{"div":125,"Nextclade_pango":{"value":"XEE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.013909816741943}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","G17334T","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","H146Q","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","T1303A","T1465I","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, T1303A, T1465I, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XF","node_attrs":{"div":57,"Nextclade_pango":{"value":"XF"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.623017311096191}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","T1390C","A2255G","C3037T","G4181T","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29632T"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp2":["I484V"],"nsp3":["A488S","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp2: I484V; nsp3: A488S, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XEF","node_attrs":{"div":124,"Nextclade_pango":{"value":"XEF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.12538"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":34.028},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7268345560655398"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","G4255T","C4321T","C4683T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","N211-","L212I","V213G","L216F","H245N","A264D","I332V","L335S","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","A655V","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, A655V, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XH","node_attrs":{"div":65,"Nextclade_pango":{"value":"XH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.385257720947266}},"branch_attrs":{"mutations":{"nuc":["C241T","T902C","C904A","G1244A","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28435T","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-","P51L"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["C33R","G147S"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-, P51L; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: C33R, G147S; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XG","node_attrs":{"div":69,"Nextclade_pango":{"value":"XG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","T5386G","C5672T","G5924A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19855G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["I79V","T112I"],"nsp3":["K38R","P985S","V1069I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: I79V, T112I; nsp3: K38R, P985S, V1069I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XJ","node_attrs":{"div":65,"Nextclade_pango":{"value":"XJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","G11287-","T11288-","C11289-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106F","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106F, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XK","node_attrs":{"div":59,"Nextclade_pango":{"value":"XK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-3.62446"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A16064G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23403G","C23525T","T23599G","C23604A","A23767G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L","Q875R"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","R810C","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L, Q875R; nsp14: I42V; nsp15: T112I; nsp3: K38R, R810C, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XL","node_attrs":{"div":68,"Nextclade_pango":{"value":"XL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","C875T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G14229A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["L24F"],"nsp3":["K38R","V1069I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: L24F; nsp3: K38R, V1069I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XM","node_attrs":{"div":60,"Nextclade_pango":{"value":"XM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.202031135559082}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XP","node_attrs":{"div":59,"Nextclade_pango":{"value":"XP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.023200000000000068"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3616394203564539"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.596989154815674}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24190C","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","C26880A","A27259C","C27807T","A28254-","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3G","Q19E","A63T","L120I"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF6":["L61D"],"ORF8":["I121-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T, L120I; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF6: L61D; ORF8: I121-; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XN","node_attrs":{"div":67,"Nextclade_pango":{"value":"XN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.3213419914245605}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","G10986A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["R5K","S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: R5K, S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XQ","node_attrs":{"div":66,"Nextclade_pango":{"value":"XQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.557600498199463}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A17615G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C","K460R"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C, K460R; nsp14: I42V; nsp15: T112I; nsp3: K38R; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XS","node_attrs":{"div":61,"Nextclade_pango":{"value":"XS"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.812868118286133}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5365T","C6196T","C6402T","C7124T","C8986T","G9053T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21595T","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["A488S","P1228L","P1469S"],"nsp4":["V167L","T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp3: A488S, P1228L, P1469S; nsp4: V167L, T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XT","node_attrs":{"div":63,"Nextclade_pango":{"value":"XT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.9682207107543945}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13994T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21786T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G75V","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["A185V","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: A185V, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XR","node_attrs":{"div":69,"Nextclade_pango":{"value":"XR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C4893T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G13295A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25524G","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","C27131T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp10":["D91N"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","T725I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp10: D91N; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, T725I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XU","node_attrs":{"div":67,"Nextclade_pango":{"value":"XU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.814977645874023}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C16887T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XW","node_attrs":{"div":68,"Nextclade_pango":{"value":"XW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","C10507T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12756T","C12880T","C14408T","C15714T","G16020T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T24I"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T24I","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XV","node_attrs":{"div":62,"Nextclade_pango":{"value":"XV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.5818281173706055}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3583T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XY","node_attrs":{"div":68,"Nextclade_pango":{"value":"XY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A1585G","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11049C","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","A22351G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26058T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["V26A","L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: V26A, L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XZ","node_attrs":{"div":64,"Nextclade_pango":{"value":"XZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.045811176300049}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","G20398A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I","E260K"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I, E260K; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"internal_XBK","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBK.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":105,"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","A1124G","C1973T","A2163C","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16856G","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","G25947C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27741T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["Q185H","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","D207G","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R107G","E453A"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: Q185H, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, D207G, R392C; nsp14: I42V; nsp15: T112I; nsp2: R107G, E453A; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCH.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":105,"Nextclade_pango":{"value":"XCH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1684T","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7051T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19886G","C19955T","A20055G","C20320T","A20741G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22115G","A22190G","T22200G","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","T24073C","C24134A","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["A72T","A110V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","N185D","I210V","V213G","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["K89R","T112I","H234Y"],"nsp16":["Q28R"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: A72T, A110V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: K89R, T112I, H234Y; nsp16: Q28R; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}},"children":[{"name":"XCT.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"XCT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":105,"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["T85A","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp2":["D155G"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: T85A, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp2: D155G; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDA.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"XDA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":105,"Nextclade_pango":{"value":"XDA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":127,"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18657T","C18894T","C19716T","C19955T","A20055G","C21618T","C21622T","G21624C","C21627A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25006T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28291A","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G28884C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204P","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P3H","P10S","E27-","N28-","A29-"],"S":["R21T","T22N","L24-","P25-","P26-","A27S","S50L","F59S","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204P, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P3H, P10S, E27-, N28-, A29-; S: R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"XEC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":29.34},"designation_date":{"value":"2024-08-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"S":["K182R"],"nsp2":["A419T"],"nsp9":["L42F"]},"labels":{"aa":"S: K182R; nsp2: A419T; nsp9: L42F","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":127,"Nextclade_pango":{"value":"XEC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":34.028},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4006A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17067C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","T26012G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["F207C","T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: F207C, T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCF","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"XCF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XCF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XCF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R","T170I"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R, T170I; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"S":["E1092D"],"nsp2":["H208Y","L217P"]},"labels":{"aa":"S: E1092D; nsp2: H208Y, L217P","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2668T","C2790T","C3037T","G4184A","C4321T","C6896T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"S":["F59S","R346T"],"nsp3":["A1120S"]},"labels":{"aa":"S: F59S, R346T; nsp3: A1120S","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF8":["E92K"],"S":["F456L"],"nsp16":["A83D"],"nsp3":["A1324V"]},"labels":{"aa":"ORF8: E92K; S: F456L; nsp16: A83D; nsp3: A1324V","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"nsp14":["L366F"],"nsp6":["L185F"]},"labels":{"aa":"nsp14: L366F; nsp6: L185F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G3446A","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","A20379G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","A243T","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, A243T, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBL","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBL.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}},{"name":"XBL.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","C7420T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A27980G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","T29023C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDQ","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":114,"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.493661403656006}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.3","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDQ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"XDQ.2","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"S":["N487D"],"nsp4":["F39C"]},"labels":{"aa":"S: N487D; nsp4: F39C","spike_mutations":"N487D"}}},{"name":"NODE_0000019","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.296817302703857}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.296817302703857}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1471T","C2445T","C2790T","C3037T","G3072A","G4184A","C4321T","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10189T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C12880T","C14408T","C15714T","C17410T","C17678T","A18163G","C18252T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22020C","T22054G","T22200G","C22295A","G22332A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893G","A22910G","C22916A","T22942G","G22992A","C22995A","G23012A","A23013G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25896T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","M153T","N164K","V213G","H245N","G257D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444R","N450D","L452M","N460K","S477N","T478K","E484R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C","T481M"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["T547I"],"nsp3":["T24I","C118Y","G489S","I896T","M1351V","T1356I","A1766V","T1830I"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp7":["Q63R"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C, T481M; nsp14: I42V; nsp15: T112I; nsp2: T547I; nsp3: T24I, C118Y, G489S, I896T, M1351V, T1356I, A1766V, T1830I; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp7: Q63R","spike_mutations":"L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBJ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000021","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"nsp4":["K165N"]},"labels":{"aa":"nsp4: K165N"}}},{"name":"XBJ.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"S":["F456L","T572I"],"nsp14":["T524A"]},"labels":{"aa":"S: F456L, T572I; nsp14: T524A","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDD.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","C23277T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","T572I","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.2","node_attrs":{"div":125,"Nextclade_pango":{"value":"XDK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","C22928T","A23598G","C27297T"],"S":["L456F","K679R"]},"labels":{"aa":"S: L456F, K679R","spike_mutations":"L456F, K679R"}}},{"name":"XDK.3","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"nsp5":["F134L"]},"labels":{"aa":"nsp5: F134L"}}},{"name":"XDK.5","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.635818004608154}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"internal_0964eaa1","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"XDK.4.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDK.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T"],"nsp14":["P203S"],"nsp2":["T528I"],"nsp3":["A264V"]},"labels":{"aa":"nsp14: P203S; nsp2: T528I; nsp3: A264V"}}}]},{"name":"internal_C29762T","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, Q1201K","spike_mutations":"R237K, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G11596A","C18664T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.2","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.803860664367676}},"branch_attrs":{"mutations":{"nuc":["G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"NODE_0000032","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":129,"Nextclade_pango":{"value":"XDK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0469899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","T18664C","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"XDK.1","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["C241T","G625T","T670G","C1627T","C2790T","C3037T","T3339C","G4184A","C4321T","C6070T","C8692T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K120N","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","V207A","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K120N, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, V207A, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBF","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000034","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.10"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"nsp2":["V94I"]},"labels":{"aa":"nsp2: V94I"}}},{"name":"XBF.5","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.3351006507873535}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.6","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"nsp8":["V44A"]},"labels":{"aa":"nsp8: V44A"}}},{"name":"XBF.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"nsp2":["H237Y"]},"labels":{"aa":"nsp2: H237Y"}}},{"name":"XBF.9","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.9"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"nsp13":["S80G"]},"labels":{"aa":"nsp13: S80G"}}},{"name":"NODE_0000035","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"S":["P621S"],"nsp3":["G337C"]},"labels":{"aa":"S: P621S; nsp3: G337C","spike_mutations":"P621S"}}}]},{"name":"NODE_0000036","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"nsp1":["N120K"]},"labels":{"aa":"N: T379I; nsp1: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBF.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"S":["T323I"],"nsp14":["Q354E"]},"labels":{"aa":"S: T323I; nsp14: Q354E","spike_mutations":"T323I"}}}]},{"name":"NODE_0000037","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBF.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"S":["P621S"],"nsp1":["K141-","S142-","F143-"]},"labels":{"aa":"S: P621S; nsp1: K141-, S142-, F143-","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C12880T","C14408T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","A21623G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23423T","C23525T","T23599G","C23604A","C23679T","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","C26681T","T26767C","G26959A","C27575G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"M":["I82T","R146H"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["T61S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L18F","I19R","R21G","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","P621S","H655Y","N679K","P681H","A706V","N764K","D796Y","Q954H","N969K","T1117I"],"nsp1":["S135R"],"nsp12":["P323L","A529V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["T24I","G489S","P1469S"],"nsp4":["T14I","V167L","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T21I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: S26L; ORF6: L61D; ORF7a: T61S; ORF9b: P10S, E27-, N28-, A29-; S: L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I; nsp1: S135R; nsp12: P323L, A529V, G671S; nsp13: P77L; nsp14: A394V; nsp3: T24I, G489S, P1469S; nsp4: T14I, V167L, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T21I","spike_mutations":"L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000039","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":79,"Nextclade_pango":{"value":"XAY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"nsp14":["D345Y"]},"labels":{"aa":"nsp14: D345Y"}}},{"name":"NODE_0000040","node_attrs":{"div":80,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.995934963226318}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"nsp6":["Y196C"]},"labels":{"aa":"nsp6: Y196C"}},"children":[{"name":"XAY.2","node_attrs":{"div":80,"Nextclade_pango":{"value":"XAY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.995934963226318}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000041","node_attrs":{"div":81,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.154902458190918}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"nsp4":["I363T"]},"labels":{"aa":"nsp4: I363T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":82,"Nextclade_pango":{"value":"XAY.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000204563140869}},"branch_attrs":{"mutations":{"nuc":["C657T"],"nsp1":["A131V"]},"labels":{"aa":"nsp1: A131V"}}},{"name":"NODE_0000042","node_attrs":{"div":82,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.154902458190918}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":83,"Nextclade_pango":{"value":"XAY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796263694763184}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.699412822723389}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"nsp1":["R124C"],"nsp2":["N267S"]},"labels":{"aa":"nsp1: R124C; nsp2: N267S"}}}]}]}]},{"name":"NODE_0000043","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.521972179412842}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"S":["D253G"],"nsp1":["D48N"],"nsp4":["I289V"],"nsp5":["Q83K"]},"labels":{"aa":"S: D253G; nsp1: D48N; nsp4: I289V; nsp5: Q83K","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.521972179412842}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF9b":["S50L"],"nsp6":["T77I"]},"labels":{"aa":"ORF9b: S50L; nsp6: T77I"}}},{"name":"NODE_0000044","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"S":["R346T"],"nsp3":["K1290N"]},"labels":{"aa":"S: R346T; nsp3: K1290N","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF7a":["S61T"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"ORF7a: S61T; nsp1: G82-, H83-, V84-, M85V"}}},{"name":"NODE_0000045","node_attrs":{"div":87,"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XAY.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.0969953536987305}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000046","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"GL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.778546333312988}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"nsp3":["P822S"]},"labels":{"aa":"nsp3: P822S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000047","node_attrs":{"div":89,"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.697271823883057}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"GL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6888599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752889267417711"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.495382308959961}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"GL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF9b":["R13L"],"nsp2":["S543P"]},"labels":{"aa":"ORF9b: R13L; nsp2: S543P"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["S122F"],"nsp3":["T24I","G489S","P1261Q","T1465I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["P80L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: S122F; nsp3: T24I, G489S, P1261Q, T1465I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: P80L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000049","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":125,"Nextclade_pango":{"value":"XDV.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.10"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"S":["G181V"],"nsp9":["T35I"]},"labels":{"aa":"S: G181V; nsp9: T35I","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.11"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.3"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.5","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDV.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14808999999999992"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5359962252743784"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.5"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.4","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.4"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.6","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDV.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.6"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"nsp3":["E391D","T611I","V965I"]},"labels":{"aa":"nsp3: E391D, T611I, V965I"}}},{"name":"XDV.1.8","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.8"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000050","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"S":["R346T"],"nsp4":["L353F"]},"labels":{"aa":"N: I292T; S: R346T; nsp4: L353F","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"XDV.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26874999999999993"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":6.25},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.8051577060608006"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"S":["K462R"],"nsp6":["L260F"]},"labels":{"aa":"S: K462R; nsp6: L260F","spike_mutations":"K462R"}}}]},{"name":"NODE_0000051","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"nsp4":["D217N"]},"labels":{"aa":"nsp4: D217N"}},"children":[{"name":"XDV.1.7.1","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDV.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"2-3 weeks"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"S":["T22N","V62F"],"nsp2":["L501F"]},"labels":{"aa":"S: T22N, V62F; nsp2: L501F","spike_mutations":"T22N, V62F"}}},{"name":"XDV.1.7","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000052","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"nsp3":["T1379I"]},"labels":{"aa":"nsp3: T1379I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDV.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20783000000000001"},"designation_recency":{"value":"2-3 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5422010449483097"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","C9891T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23670T","C23854A","G23948T","A24424T","T24469A","C25000T","C25854T","T26767C","T26819C","T27718C","C27752T","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["T60A"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","P209L","L212S","D215H","A222V","L242-","A243-","S256L","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N703I","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["P77L","T127I"],"nsp3":["T24I","T725I","P822L","S1286I","V1458I"],"nsp4":["A446V"],"nsp6":["V149A","T181I"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: T60A; S: P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: P77L, T127I; nsp3: T24I, T725I, P822L, S1286I, V1458I; nsp4: A446V; nsp6: V149A, T181I","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6871599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000054","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000055","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"S":["K97R"],"nsp4":["V102I"]},"labels":{"aa":"S: K97R; nsp4: V102I","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":72,"Nextclade_pango":{"value":"XBC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6871599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF8":["D34-"],"nsp2":["A318V"]},"labels":{"aa":"ORF8: D34-; nsp2: A318V"}}},{"name":"XBC.2.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.58838"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.44507236664312827"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF8":["A15T"],"S":["K444T"],"nsp3":["G489S"]},"labels":{"aa":"ORF8: A15T; S: K444T; nsp3: G489S","spike_mutations":"K444T"}}}]},{"name":"NODE_0000056","node_attrs":{"div":69,"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"S":["L452M"],"nsp2":["S211F"]},"labels":{"aa":"S: L452M; nsp2: S211F","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":69,"Nextclade_pango":{"value":"XBC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000057","node_attrs":{"div":70,"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"nsp4":["T492I"]},"labels":{"aa":"nsp4: T492I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"S":["G184S"],"nsp1":["G82-","H83-","V84-"],"nsp12":["T803P"],"nsp8":["P10S","V130A"]},"labels":{"aa":"S: G184S; nsp1: G82-, H83-, V84-; nsp12: T803P; nsp8: P10S, V130A","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":74,"Nextclade_pango":{"value":"XBC.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"nsp2":["T528I"],"nsp3":["A1179V"]},"labels":{"aa":"nsp2: T528I; nsp3: A1179V"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"nsp12":["T141I"]},"labels":{"aa":"nsp12: T141I"}}},{"name":"XBC.1.2","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}}]},{"name":"NODE_0000059","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF8":["V114L"],"nsp1":["K141-","S142-","F143-"],"nsp6":["I50T"]},"labels":{"aa":"ORF8: V114L; nsp1: K141-, S142-, F143-; nsp6: I50T"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000060","node_attrs":{"div":78,"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"XBC.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11213999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48837241784414276"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF3a":["P262L"],"ORF7a":["P34L"],"nsp1":["R124C"]},"labels":{"aa":"ORF3a: P262L; ORF7a: P34L; nsp1: R124C"}}}]}]},{"name":"NODE_0000061","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF7a":["T14I"],"S":["K444T","K478R"],"nsp13":["Y324C"]},"labels":{"aa":"ORF7a: T14I; S: K444T, K478R; nsp13: Y324C","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":79,"Nextclade_pango":{"value":"XBC.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"S":["T299I"],"nsp3":["V188I"]},"labels":{"aa":"S: T299I; nsp3: V188I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000062","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000063","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp12":["S768N"],"nsp2":["Q275K"],"nsp3":["V1243A"],"nsp9":["T34I"]},"labels":{"aa":"ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-; nsp1: G82-, H83-, V84-, M85-, V86-; nsp12: S768N; nsp2: Q275K; nsp3: V1243A; nsp9: T34I"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"nsp3":["E115V"]},"labels":{"aa":"nsp3: E115V"}},"children":[{"name":"KD.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"KD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF3a":["T151I"],"nsp6":["M92L"],"nsp7":["M75I"]},"labels":{"aa":"ORF3a: T151I; nsp6: M92L; nsp7: M75I"}}},{"name":"KD.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"KD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7857899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"KD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":82,"Nextclade_pango":{"value":"KD.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"nsp2":["K214R","L550F"],"nsp3":["T147I"]},"labels":{"aa":"nsp2: K214R, L550F; nsp3: T147I"}}}]}]}]},{"name":"NODE_0000065","node_attrs":{"div":83,"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"S":["R346S","M452R"],"nsp13":["I333V"],"nsp2":["A510V"],"nsp3":["C296F","H1841Y"]},"labels":{"aa":"S: R346S, M452R; nsp13: I333V; nsp2: A510V; nsp3: C296F, H1841Y","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":83,"Nextclade_pango":{"value":"XBC.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"nsp3":["D9N"]},"labels":{"aa":"nsp3: D9N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"nsp3":["V299I"]},"labels":{"aa":"nsp3: V299I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBC.1.6.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF7a":["Q90*"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp12":["R721C"]},"labels":{"aa":"ORF7a: Q90*; nsp1: G82-, H83-, V84-, M85V; nsp12: R721C"}}},{"name":"NODE_0000066","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"GT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000067","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"JT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47217000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7550301657183831"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"S":["V445A"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"S: V445A; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":85,"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":85,"Nextclade_pango":{"value":"XBC.1.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000069","node_attrs":{"div":88,"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"nsp3":["T779I","A1305V"]},"labels":{"aa":"nsp3: T779I, A1305V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"HW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.63844"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420325830319254"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","clade":"22F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBB","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000071","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000072","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"nsp1":["G82D"]},"labels":{"aa":"nsp1: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"nsp4":["V103M"],"nsp6":["V182F"]},"labels":{"aa":"N: T49I; nsp4: V103M; nsp6: V182F"}}},{"name":"NODE_0000073","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3064099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26627999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0810114368008295"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"S":["L5F","T470N"],"nsp3":["N833K"]},"labels":{"aa":"S: L5F, T470N; nsp3: N833K","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000074","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4179558753967285}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000075","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000076","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"nsp2":["K454N"],"nsp5":["K90R"]},"labels":{"aa":"nsp2: K454N; nsp5: K90R"}}},{"name":"XBB.8.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"nsp14":["I474V"]},"labels":{"aa":"nsp14: I474V"}},"children":[{"name":"XBB.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.83066463470459}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}}},{"name":"NODE_0000079","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"S":["V1122L"],"nsp12":["A529T"]},"labels":{"aa":"S: V1122L; nsp12: A529T","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.122056484222412}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.122056484222412}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.165473937988281}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.636689186096191}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.256861209869385}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"S":["S486P"],"nsp3":["V1209I"]},"labels":{"aa":"S: S486P; nsp3: V1209I","spike_mutations":"S486P"}}},{"name":"NODE_0000081","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.454007148742676}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}},{"name":"XBB.2.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.454007148742676}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000082","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"nsp6":["R93H"]},"labels":{"aa":"nsp6: R93H"}},"children":[{"name":"XBB.2.7.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65097"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"S":["Y453F","K478Q"],"nsp2":["E70D"]},"labels":{"aa":"S: Y453F, K478Q; nsp2: E70D","spike_mutations":"Y453F, K478Q"}}},{"name":"XBB.2.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000083","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.832684516906738}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000084","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"ORF10":["Q29*"],"S":["Q613H"]},"labels":{"aa":"ORF10: Q29*; S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35217"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35217"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF7a":["A13V"],"S":["S486P","P521S"],"nsp13":["P36S"],"nsp3":["G1273S"]},"labels":{"aa":"ORF7a: A13V; S: S486P, P521S; nsp13: P36S; nsp3: G1273S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF7a":["H47Y"],"S":["D80Y"],"nsp12":["A250T"]},"labels":{"aa":"ORF7a: H47Y; S: D80Y; nsp12: A250T","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.14"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"nsp3":["Q180H"]},"labels":{"aa":"nsp3: Q180H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.2.3.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0750199999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2567103717994188"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.18"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.20","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.20"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.21","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.2.3.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.21"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"S":["T883I"],"nsp1":["R135S"],"nsp4":["D279N"]},"labels":{"aa":"S: T883I; nsp1: R135S; nsp4: D279N","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.22"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84876"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.456076622009277}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"nsp8":["T145I"]},"labels":{"aa":"nsp8: T145I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.9"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.92117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.92117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"nsp3":["T1004I"]},"labels":{"aa":"nsp3: T1004I"}},"children":[{"name":"JA.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"JA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13359999999999994"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"JU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84789"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0527558336884004"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90647"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.90196418762207}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"nsp4":["D144N"]},"labels":{"aa":"nsp4: D144N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84876"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.16"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89912"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.17"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"nsp10":["I55V"]},"labels":{"aa":"nsp10: I55V"}},"children":[{"name":"JS.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"JS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"S":["T323I"],"nsp6":["M100I"]},"labels":{"aa":"S: T323I; nsp6: M100I","spike_mutations":"T323I"}}},{"name":"JS.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"JS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"XBB.2.3.15","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"S":["G184V"],"nsp3":["P968L"]},"labels":{"aa":"S: G184V; nsp3: P968L","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":105,"Nextclade_pango":{"value":"JY.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"S":["K478T","E654K"],"nsp16":["K182R"],"nsp5":["P241L"]},"labels":{"aa":"S: K478T, E654K; nsp16: K182R; nsp5: P241L","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.88039"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.88039"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.972652912139893}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"nsp8":["R75K"]},"labels":{"aa":"nsp8: R75K"}},"children":[{"name":"GM.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GM.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89932"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736186906064397"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"S":["N388K"],"nsp4":["S336L"]},"labels":{"aa":"S: N388K; nsp4: S336L","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"S":["K478R"],"nsp2":["A403V"],"nsp6":["L260F"]},"labels":{"aa":"S: K478R; nsp2: A403V; nsp6: L260F","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"nsp4":["I23V"]},"labels":{"aa":"nsp4: I23V"}},"children":[{"name":"HG.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"HG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"S":["S255F"],"nsp3":["S1455F"]},"labels":{"aa":"S: S255F; nsp3: S1455F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"HG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":102,"Nextclade_pango":{"value":"HG.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"HG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HG.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"internal_aa639495","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7709600000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0079043361863298"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF3a":["I179V"],"nsp8":["L169F"]},"labels":{"aa":"ORF3a: I179V; nsp8: L169F"}}}]},{"name":"NODE_0000102","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.295290470123291}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":110,"Nextclade_pango":{"value":"GS.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"S":["A845S"],"nsp1":["I114V"],"nsp12":["A581V"],"nsp13":["H164Y"],"nsp3":["K394-","P395-","F396-","S1813P"],"nsp4":["V403I"]},"labels":{"aa":"S: A845S; nsp1: I114V; nsp12: A581V; nsp13: H164Y; nsp3: K394-, P395-, F396-, S1813P; nsp4: V403I","spike_mutations":"A845S"}}}]},{"name":"NODE_0000103","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.607783794403076}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GS.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"S":["R190S"],"nsp15":["F279L"]},"labels":{"aa":"S: R190S; nsp15: F279L","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":100,"Nextclade_pango":{"value":"GS.7"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"nsp2":["L24I"]},"labels":{"aa":"nsp2: L24I"}},"children":[{"name":"GS.7.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"GS.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"S":["E180Q"],"nsp2":["G339S"]},"labels":{"aa":"S: E180Q; nsp2: G339S","spike_mutations":"E180Q"}}},{"name":"GS.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"GS.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"S":["Q218H"],"nsp3":["T1004I"]},"labels":{"aa":"S: Q218H; nsp3: T1004I","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.4"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"nsp2":["A1T"]},"labels":{"aa":"nsp2: A1T"}},"children":[{"name":"GS.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GS.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"S":["G184V"],"nsp3":["R1341W"]},"labels":{"aa":"S: G184V; nsp3: R1341W","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"HH.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"nsp3":["T970M"]},"labels":{"aa":"nsp3: T970M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"HH.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF8":["T26I"],"S":["K147N"],"nsp2":["L113I"],"nsp9":["P57S"]},"labels":{"aa":"ORF8: T26I; S: K147N; nsp2: L113I; nsp9: P57S","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":106,"Nextclade_pango":{"value":"HH.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF8":["G8R"],"S":["K478R"],"nsp3":["D117E"]},"labels":{"aa":"ORF8: G8R; S: K478R; nsp3: D117E","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HH.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000111","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"internal_bb69915a","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"nsp4":["T214I"]},"labels":{"aa":"nsp4: T214I"}},"children":[{"name":"HH.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}},{"name":"HH.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HH.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"nsp1":["D48Y"]},"labels":{"aa":"nsp1: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"HH.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"S":["K478R"],"nsp16":["T140I"],"nsp5":["S81F"]},"labels":{"aa":"S: K478R; nsp16: T140I; nsp5: S81F","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":98,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":99,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"nsp13":["I480V"]},"labels":{"aa":"nsp13: I480V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"GE.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"nsp5":["P96S"]},"labels":{"aa":"nsp5: P96S"}}},{"name":"GE.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"GE.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"internal_d2763520","node_attrs":{"div":100,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.00916051864624}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"nsp2":["G481S"]},"labels":{"aa":"nsp2: G481S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"S":["L118I"],"nsp9":["A8T"]},"labels":{"aa":"S: L118I; nsp9: A8T","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF7a":["P99S"],"S":["N148T"],"nsp10":["V116A"],"nsp3":["P1103S"]},"labels":{"aa":"ORF7a: P99S; S: N148T; nsp10: V116A; nsp3: P1103S","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"GE.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.70075"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.986824739722089"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp12":["A526V"],"nsp14":["D375E"]},"labels":{"aa":"ORF6: L61H; ORF7b: F19L; S: S408N; nsp1: G82-, H83-, V84-, M85-, V86-; nsp12: A526V; nsp14: D375E","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":107,"Nextclade_pango":{"value":"GE.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF3a":["S195C"],"S":["A376S","R478T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF3a: S195C; S: A376S, R478T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GE.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":111,"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"KT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":112,"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KT.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":114,"Nextclade_pango":{"value":"KT.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"nsp15":["N277S"]},"labels":{"aa":"nsp15: N277S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.2036452293396}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"nsp15":["V320L"],"nsp3":["P153S"]},"labels":{"aa":"nsp15: V320L; nsp3: P153S"}}},{"name":"GJ.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"S":["I1114S"],"nsp12":["T803I"]},"labels":{"aa":"S: I1114S; nsp12: T803I","spike_mutations":"I1114S"}}},{"name":"GJ.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"GJ.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13359999999999994"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"S":["F456L"],"nsp3":["T73I","Y996C"]},"labels":{"aa":"M: G6S; S: F456L; nsp3: T73I, Y996C","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"S":["E183K"],"nsp14":["P203S"]},"labels":{"aa":"S: E183K; nsp14: P203S","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.5"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GJ.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"S":["S255F"],"nsp2":["A360V"],"nsp8":["A21V"]},"labels":{"aa":"S: S255F; nsp2: A360V; nsp8: A21V","spike_mutations":"S255F"}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF8":["E106Q"],"nsp9":["I65V"]},"labels":{"aa":"ORF8: E106Q; nsp9: I65V"}},"children":[{"name":"GJ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"S":["A222V"],"nsp3":["V1097I","N1410S"]},"labels":{"aa":"N: R319H; S: A222V; nsp3: V1097I, N1410S","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":103,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"nsp13":["V187I"]},"labels":{"aa":"nsp13: V187I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"GJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GJ.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF9b":["I5T"],"S":["K478R"],"nsp3":["G334C"]},"labels":{"aa":"ORF9b: I5T; S: K478R; nsp3: G334C","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"nsp3":["H101Y"]},"labels":{"aa":"nsp3: H101Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"GJ.1.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF8":["G8V"],"S":["S255F"],"nsp3":["C1342Y"]},"labels":{"aa":"ORF8: G8V; S: S255F; nsp3: C1342Y","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"nsp13":["S74P"]},"labels":{"aa":"nsp13: S74P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.6","node_attrs":{"div":105,"Nextclade_pango":{"value":"GJ.1.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4524970054626465}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.5","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}}]},{"name":"internal_18110768","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89912"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":108,"Nextclade_pango":{"value":"JE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"JE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":109,"Nextclade_pango":{"value":"JE.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":110,"Nextclade_pango":{"value":"JE.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"JE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"KH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF7a":["V71L"],"S":["E554K"],"nsp1":["R135S"]},"labels":{"aa":"N: L13F; ORF7a: V71L; S: E554K; nsp1: R135S","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.0628252029418945}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.0628252029418945}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13558"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"ORF10":["A8V"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"ORF10: A8V; S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49564"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"S":["A484T"],"nsp3":["P1469S"]},"labels":{"aa":"S: A484T; nsp3: P1469S","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"S":["S486P"],"nsp13":["L138I"]},"labels":{"aa":"S: S486P; nsp13: L138I","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0545"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.33"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"],"nsp1":["V84-","M85-"],"nsp3":["T847I","Q1668P"]},"labels":{"aa":"ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E; nsp1: V84-, M85-; nsp3: T847I, Q1668P","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89405"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.49"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"S":["T346S"],"nsp1":["R124C"]},"labels":{"aa":"S: T346S; nsp1: R124C","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.541812419891357}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.20"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF3a":["A72V"],"nsp10":["P59T"]},"labels":{"aa":"ORF3a: A72V; nsp10: P59T"}}},{"name":"XBB.1.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.9722600000000003"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.48"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.19.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"S":["P521S"],"nsp3":["T1251I"]},"labels":{"aa":"S: P521S; nsp3: T1251I","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"S":["D936G"],"nsp3":["T820I","P1228S"]},"labels":{"aa":"S: D936G; nsp3: T820I, P1228S","spike_mutations":"D936G"}}},{"name":"GW.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"GW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"nsp1":["S100N"],"nsp5":["N274S"]},"labels":{"aa":"nsp1: S100N; nsp5: N274S"}}},{"name":"GW.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"GW.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"nsp5":["M17I"]},"labels":{"aa":"nsp5: M17I"}}},{"name":"XBB.1.19.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":103,"Nextclade_pango":{"value":"GW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF9b":["T79I"],"nsp2":["D84N"]},"labels":{"aa":"N: M322V; ORF9b: T79I; nsp2: D84N"}},"children":[{"name":"GW.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"GW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"GW.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"S":["F456L"],"nsp16":["K160R"]},"labels":{"aa":"S: F456L; nsp16: K160R","spike_mutations":"F456L"}}}]},{"name":"NODE_0000141","node_attrs":{"div":108,"Nextclade_pango":{"value":"GW.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"S":["L455F","F456L","K478I"],"nsp2":["S122F"],"nsp3":["P1261Q"],"nsp9":["P80L"]},"labels":{"aa":"N: P80S; S: L455F, F456L, K478I; nsp2: S122F; nsp3: P1261Q; nsp9: P80L","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"GW.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"GW.5.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"S":["G184A","A475V"],"nsp2":["I514V"]},"labels":{"aa":"S: G184A, A475V; nsp2: I514V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":116,"Nextclade_pango":{"value":"GW.5.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"],"nsp1":["P62L"]},"labels":{"aa":"ORF3a: G172C; ORF6: L61H; S: F79S, A475V; nsp1: P62L","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"GW.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.1","node_attrs":{"div":121,"Nextclade_pango":{"value":"KE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.2","node_attrs":{"div":121,"Nextclade_pango":{"value":"KE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"S":["S704L"],"nsp3":["A1766V"]},"labels":{"aa":"S: S704L; nsp3: A1766V","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":118,"Nextclade_pango":{"value":"KE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"nsp12":["T739I"],"nsp6":["L72S"]},"labels":{"aa":"nsp12: T739I; nsp6: L72S"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.1273951530456543}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86729"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.21"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"S":["S486A"],"nsp3":["K429R"]},"labels":{"aa":"S: S486A; nsp3: K429R","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2602599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.27"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"S":["K478R","A890V"],"nsp12":["N88I"]},"labels":{"aa":"S: K478R, A890V; nsp12: N88I","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.29"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"S":["A292S"],"nsp6":["G48C","L260F"]},"labels":{"aa":"S: A292S; nsp6: G48C, L260F","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.36"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.40"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF3a":["P104S"],"S":["Y453F"],"nsp2":["G339S"],"nsp3":["L1791F"]},"labels":{"aa":"ORF3a: P104S; S: Y453F; nsp2: G339S; nsp3: L1791F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.88502836227417}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"S":["V608I"],"nsp3":["K233N"]},"labels":{"aa":"S: V608I; nsp3: K233N","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"S":["Q146K","L216F"],"nsp3":["C55F","H1702Q"]},"labels":{"aa":"S: Q146K, L216F; nsp3: C55F, H1702Q","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393089294433594}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"S":["Y453F"],"nsp12":["D260N","T643A"],"nsp2":["S36F"],"nsp4":["A69V"]},"labels":{"aa":"S: Y453F; nsp12: D260N, T643A; nsp2: S36F; nsp4: A69V","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"S":["Q613H","E1202Q"],"nsp2":["T434I"]},"labels":{"aa":"S: Q613H, E1202Q; nsp2: T434I","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.727348327636719}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.727348327636719}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"S":["Q564E","N856K"],"nsp3":["T1368A"]},"labels":{"aa":"S: Q564E, N856K; nsp3: T1368A","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000148","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"nsp2":["A360V"]},"labels":{"aa":"nsp2: A360V"}},"children":[{"name":"XBB.1.15.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.15","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_234859ae","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.930898189544678}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.930898189544678}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_8d12","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.231898784637451}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.37.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.231898784637451}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_97a057d5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.254012107849121}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"S":["S486P"],"nsp3":["A1803V"]},"labels":{"aa":"S: S486P; nsp3: A1803V","spike_mutations":"S486P"}}},{"name":"XBB.1.43","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.254012107849121}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_fcda1063","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.44.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF3a":["S195F"],"S":["S486P"],"nsp2":["A360V"]},"labels":{"aa":"ORF3a: S195F; S: S486P; nsp2: A360V","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.039512634277344}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.45.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.45","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.039512634277344}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000155","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"S":["Y453F","K478R"],"nsp2":["P129L"],"nsp3":["W1414C"]},"labels":{"aa":"S: Y453F, K478R; nsp2: P129L; nsp3: W1414C","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF3a":["V197L"],"S":["E554K"],"nsp3":["H342Y"],"nsp6":["L19F"]},"labels":{"aa":"ORF3a: V197L; S: E554K; nsp3: H342Y; nsp6: L19F","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.31.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"nsp3":["A231V"]},"labels":{"aa":"nsp3: A231V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"S":["S486P"],"nsp6":["V26F"]},"labels":{"aa":"S: S486P; nsp6: V26F","spike_mutations":"S486P"}}},{"name":"XBB.1.4.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF9b":["R47C"],"S":["S486P","H681R"],"nsp13":["V169I"]},"labels":{"aa":"N: A50V; ORF9b: R47C; S: S486P, H681R; nsp13: V169I","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"S":["E554K"],"nsp13":["P47L"]},"labels":{"aa":"S: E554K; nsp13: P47L","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF8":["C90F"],"S":["K182I"],"nsp3":["G171C"]},"labels":{"aa":"ORF8: C90F; S: K182I; nsp3: G171C","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.34.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9296858310699463}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.30"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.753546237945557}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}}},{"name":"XBB.1.39","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.39"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.072872638702393}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"nsp4":["V103M"]},"labels":{"aa":"nsp4: V103M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"nsp1":["E148D"]},"labels":{"aa":"nsp1: E148D"}},"children":[{"name":"XBB.1.32.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF7a":["A50S"],"S":["Y453F"],"nsp16":["L100I"],"nsp2":["L462F"],"nsp3":["T1303I"]},"labels":{"aa":"ORF7a: A50S; S: Y453F; nsp16: L100I; nsp2: L462F; nsp3: T1303I","spike_mutations":"Y453F"}}},{"name":"XBB.1.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.579292297363281}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05231"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"S":["L335S"],"nsp15":["S161I"]},"labels":{"aa":"S: L335S; nsp15: S161I","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.856406211853027}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.095174789428711}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp3":["G1440C"]},"labels":{"aa":"nsp1: G82-, H83-, V84-, M85V; nsp3: G1440C"}}},{"name":"FW.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"nsp3":["D1809N"]},"labels":{"aa":"nsp3: D1809N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.28.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.856406211853027}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345422744750977}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF6":["F2-"],"S":["A701V"],"nsp1":["V84-","M85-"]},"labels":{"aa":"ORF6: F2-; S: A701V; nsp1: V84-, M85-","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:3-62"},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345422744750977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":99,"Nextclade_pango":{"value":"FW.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF7a":["E121*"],"S":["N148T"],"nsp10":["A32T"],"nsp13":["I525L"],"nsp3":["S20N"]},"labels":{"aa":"ORF7a: E121*; S: N148T; nsp10: A32T; nsp13: I525L; nsp3: S20N","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:3-62"},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF6":["-2F","L61H"],"S":["A684T"],"nsp3":["S1467F"],"nsp5":["K90R"]},"labels":{"aa":"ORF6: -2F, L61H; S: A684T; nsp3: S1467F; nsp5: K90R","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"S":["-24L","S27-","H69-","V70-"],"nsp3":["T1198I"]},"labels":{"aa":"S: -24L, S27-, H69-, V70-; nsp3: T1198I","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"FP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"S":["F186S"],"nsp4":["V315I"]},"labels":{"aa":"S: F186S; nsp4: V315I","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":100,"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF3a":["W149C"],"S":["K478R"],"nsp2":["I513T"],"nsp3":["T133A"]},"labels":{"aa":"ORF3a: W149C; S: K478R; nsp2: I513T; nsp3: T133A","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FP.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":101,"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FP.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7388600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"FP.2.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"S":["P521S"],"nsp1":["F143Y"]},"labels":{"aa":"S: P521S; nsp1: F143Y","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9296858310699463}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"nsp2":["P129L"]},"labels":{"aa":"nsp2: P129L"}}},{"name":"XBB.1.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.35"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"nsp1":["V89A"]},"labels":{"aa":"nsp1: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.46"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"nsp3":["C296F"]},"labels":{"aa":"nsp3: C296F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF8":["Q18*"],"nsp3":["T943I","C1362Y"],"nsp4":["I91V"]},"labels":{"aa":"ORF8: Q18*; nsp3: T943I, C1362Y; nsp4: I91V"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.47.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"S":["A260V","S486P","V1122G"],"nsp2":["K489N"]},"labels":{"aa":"S: A260V, S486P, V1122G; nsp2: K489N","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"S":["S486P"],"nsp1":["K120R"]},"labels":{"aa":"S: S486P; nsp1: K120R","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05408"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"XBB.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000173","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"nsp2":["K81N"]},"labels":{"aa":"nsp2: K81N"}},"children":[{"name":"XBB.1.24.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.24.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"XBB.1.24.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.24.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.696725368499756}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"nsp3":["D1761G"]},"labels":{"aa":"nsp3: D1761G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.696725368499756}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357577800750732}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357577800750732}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":96,"Nextclade_pango":{"value":"FE.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF3a":["F207C"],"S":["F456L"],"nsp3":["S315G"]},"labels":{"aa":"ORF3a: F207C; S: F456L; nsp3: S315G","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":98,"Nextclade_pango":{"value":"FE.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"S":["K1086R"],"nsp3":["Q173H"]},"labels":{"aa":"S: K1086R; nsp3: Q173H","spike_mutations":"K1086R"}}},{"name":"FE.1.1.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000178","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"nsp3":["T181I"]},"labels":{"aa":"nsp3: T181I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":102,"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"HE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"S":["L335S","R403K","S486P"],"nsp15":["S161I"],"nsp2":["T223I"]},"labels":{"aa":"S: L335S, R403K, S486P; nsp15: S161I; nsp2: T223I","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65784"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.41.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6066099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1099290580037755"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"S":["S494P"],"nsp12":["A195T"]},"labels":{"aa":"S: S494P; nsp12: A195T","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.41.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65784"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":101,"Nextclade_pango":{"value":"JW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"S":["K478R"],"nsp2":["L217F"]},"labels":{"aa":"S: K478R; nsp2: L217F","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"S":["Q14K"],"nsp13":["Y277H"]},"labels":{"aa":"S: Q14K; nsp13: Y277H","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"JW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.41.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":102,"Nextclade_pango":{"value":"JC.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"nsp3":["P402L"]},"labels":{"aa":"N: H300Y; nsp3: P402L"}},"children":[{"name":"JC.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"JC.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JC.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"S":["Q173K"],"nsp1":["G98S"]},"labels":{"aa":"S: Q173K; nsp1: G98S","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}},{"name":"JC.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"JC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.43418"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"S":["H339R"],"nsp3":["V238L"]},"labels":{"aa":"S: H339R; nsp3: V238L","spike_mutations":"H339R"}}},{"name":"JC.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"JC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"ORF10":["M1I"],"S":["N703I"]},"labels":{"aa":"ORF10: M1I; S: N703I","spike_mutations":"N703I"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"nsp2":["L289F"]},"labels":{"aa":"nsp2: L289F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"nsp2":["A518S"]},"labels":{"aa":"nsp2: A518S"}}},{"name":"NODE_0000188","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"GA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"nsp2":["G548C"]},"labels":{"aa":"nsp2: G548C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"nsp15":["V185I"]},"labels":{"aa":"nsp15: V185I"}},"children":[{"name":"GA.10","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"nsp12":["V128I"]},"labels":{"aa":"nsp12: V128I"}}},{"name":"GA.10.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GA.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","G13822A","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"],"nsp12":["V128I"],"nsp14":["K423R"],"nsp2":["I188V","A596V"],"nsp3":["F396S","S1285F"]},"labels":{"aa":"M: H125Y, R146H; ORF9b: T95M; S: L455F, F456L, K478R; nsp12: V128I; nsp14: K423R; nsp2: I188V, A596V; nsp3: F396S, S1285F","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}}},{"name":"GA.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"nsp12":["A195V"]},"labels":{"aa":"nsp12: A195V"}}},{"name":"GA.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T6640C","G23222A","A25927T"],"ORF3a":["I179F"],"S":["E554K"]},"labels":{"aa":"ORF3a: I179F; S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GA.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80721"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"S":["N450D","K478R"],"nsp1":["M85-"]},"labels":{"aa":"S: N450D, K478R; nsp1: M85-","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"nsp3":["I1320V"]},"labels":{"aa":"nsp3: I1320V"}},"children":[{"name":"GA.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GA.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"ORF10":["Q29*"],"S":["T250I","K478R"]},"labels":{"aa":"ORF10: Q29*; S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000192","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"nsp3":["I733V"]},"labels":{"aa":"nsp3: I733V"}}},{"name":"GA.8.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GA.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.96117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"],"nsp15":["A117V"]},"labels":{"aa":"M: H125Y; ORF8: C102F; S: K182E, S494P, E554K; nsp15: A117V","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.7"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"nsp2":["E442G"],"nsp3":["T611I"]},"labels":{"aa":"nsp2: E442G; nsp3: T611I"}},"children":[{"name":"GA.7","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GA.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90647"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000194","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"S":["K356T"],"nsp3":["N262D","S1735F"]},"labels":{"aa":"S: K356T; nsp3: N262D, S1735F","spike_mutations":"K356T"}},"children":[{"name":"GA.4.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"GA.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"S":["K558N","G1124S"],"nsp15":["P262S"]},"labels":{"aa":"S: K558N, G1124S; nsp15: P262S","spike_mutations":"K558N, G1124S"}}},{"name":"GA.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000195","node_attrs":{"div":101,"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GA.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"S":["F186L","L585F"],"nsp13":["E261D"]},"labels":{"aa":"S: F186L, L585F; nsp13: E261D","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000196","node_attrs":{"div":108,"Nextclade_pango":{"value":"GA.4.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GA.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GA.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":112,"Nextclade_pango":{"value":"GA.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"nsp3":["V521I"]},"labels":{"aa":"N: K370N; nsp3: V521I"}}},{"name":"GA.4.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"GA.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF6":["E13Q"],"S":["T572I"],"nsp2":["G339S"]},"labels":{"aa":"ORF6: E13Q; S: T572I; nsp2: G339S","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7987143993377686}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7987143993377686}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.110"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.110"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.2336883544921875}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"nsp8":["T187I"]},"labels":{"aa":"nsp8: T187I"}}},{"name":"XBB.1.5.23","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.23"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"nsp9":["P80L"]},"labels":{"aa":"nsp9: P80L"}}},{"name":"XBB.1.5.22","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.22"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"S":["Q146K"],"nsp3":["E680A"]},"labels":{"aa":"S: Q146K; nsp3: E680A","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.45","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.45"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.43","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.43"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.57","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.57"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.58"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF6":["D6G"],"S":["Q146K","S704L"],"nsp14":["V83I"]},"labels":{"aa":"ORF6: D6G; S: Q146K, S704L; nsp14: V83I","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.87"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.87"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"S":["K478T"],"nsp3":["M770K","E815K"]},"labels":{"aa":"S: K478T; nsp3: M770K, E815K","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.874494791030884}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"GF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062406063079834}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.874494791030884}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000199","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-2.2820098400115967}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.10"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.755892753601074}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"S":["F456L"],"nsp14":["A119V"]},"labels":{"aa":"S: F456L; nsp14: A119V","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.101"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.101"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.70775842666626}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.104"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.104"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.086434841156006}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.105"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.105"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"S":["K304N"],"nsp13":["Y253H"],"nsp15":["V127I"],"nsp3":["S93F"]},"labels":{"aa":"S: K304N; nsp13: Y253H; nsp15: V127I; nsp3: S93F","spike_mutations":"K304N"}}},{"name":"XBB.1.5.109","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.109"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.109"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"S":["F456L"],"nsp2":["T474A"]},"labels":{"aa":"S: F456L; nsp2: T474A","spike_mutations":"F456L"}}},{"name":"XBB.1.5.12","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.12"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.645435094833374}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.11"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9643361568450928}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"nsp2":["G221S"]},"labels":{"aa":"nsp2: G221S"}}},{"name":"XBB.1.5.18","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.18"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.739724636077881}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"nsp3":["T1482I"]},"labels":{"aa":"nsp3: T1482I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.003551483154297}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.28"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8692514896392822}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.26","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.406291484832764}},"branch_attrs":{"mutations":{"nuc":["C920T"]}}},{"name":"XBB.1.5.31","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.31"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8875620365142822}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.29","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41404999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.29"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"S":["A348V"],"nsp15":["S261L"],"nsp16":["A34V"],"nsp6":["L239F"]},"labels":{"aa":"S: A348V; nsp15: S261L; nsp16: A34V; nsp6: L239F","spike_mutations":"A348V"}}},{"name":"XBB.1.5.35","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.35"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062806606292725}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.34","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.34"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.282310962677002}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"nsp3":["T936I"]},"labels":{"aa":"nsp3: T936I"}}},{"name":"XBB.1.5.33","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.33"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.6427886486053467}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.36"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.249703407287598}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95377"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.40"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.2360076904296875}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.51"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.949040174484253}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF3a":["A54V"],"nsp4":["D246A"]},"labels":{"aa":"ORF3a: A54V; nsp4: D246A"}}},{"name":"XBB.1.5.52","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.52"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.848769187927246}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.54"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.59"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.107088088989258}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"S":["F456L"],"nsp4":["S59P"]},"labels":{"aa":"S: F456L; nsp4: S59P","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.62"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.189932823181152}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.63"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.754556179046631}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.64"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.171535968780518}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.67"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.776366710662842}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.66"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.803469181060791}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"nsp2":["G339S"]},"labels":{"aa":"nsp2: G339S"}}},{"name":"XBB.1.5.69","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.69"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.275020122528076}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"nsp4":["V180I"]},"labels":{"aa":"nsp4: V180I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.75"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.359410762786865}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.79"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.655872344970703}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.80"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.80"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.275026798248291}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.82"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91194"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.82"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.86","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.86"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.079804420471191}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"nsp4":["G105S"]},"labels":{"aa":"nsp4: G105S"}}},{"name":"XBB.1.5.85","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.85"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.85"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.97"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.97"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.438870429992676}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.99","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.99"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.99"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.521791934967041}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"nsp3":["V304A","T1303I"]},"labels":{"aa":"nsp3: V304A, T1303I"}}},{"name":"XBB.1.5.98","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.98"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.98"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000200","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.663036823272705}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"nsp12":["V257F"]},"labels":{"aa":"nsp12: V257F"}},"children":[{"name":"EM.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.39544677734375}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.663036823272705}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.362810134887695}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.174376964569092}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.362810134887695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.762918472290039}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"S":["I666V"],"nsp2":["T223I"]},"labels":{"aa":"S: I666V; nsp2: T223I","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.809896945953369}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.762918472290039}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.015121936798096}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"HA.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.779919624328613}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"nsp4":["G105S"],"nsp6":["M143V"]},"labels":{"aa":"nsp4: G105S; nsp6: M143V"}}},{"name":"XBB.1.5.108","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.108"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.108"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF9b":["V30M"],"S":["K304N"],"nsp14":["A23S"]},"labels":{"aa":"N: G30-, -33D; ORF9b: V30M; S: K304N; nsp14: A23S","spike_mutations":"K304N"}}}]},{"name":"NODE_0000204","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.923110008239746}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.943153381347656}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.923110008239746}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.120842456817627}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29094"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1023732112409157"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41123000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.120842456817627}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.741388320922852}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"nsp3":["T350I"]},"labels":{"aa":"nsp3: T350I"}},"children":[{"name":"HQ.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"HQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.92"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.741388320922852}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.495574951171875}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"HY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.282982349395752}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.100"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.495574951171875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7761480808258057}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"JK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.8508501052856445}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7761480808258057}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.523141384124756}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"JZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.971319675445557}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"S":["F456L"],"nsp14":["L157F"]},"labels":{"aa":"S: F456L; nsp14: L157F","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.107"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.523141384124756}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9941704273223877}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"KM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"],"nsp6":["T127A"]},"labels":{"aa":"N: A155V; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R; nsp6: T127A","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9941704273223877}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.398263931274414}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.50"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"S":["P621S"],"nsp3":["A1279V"]},"labels":{"aa":"N: T49I; S: P621S; nsp3: A1279V","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48403999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.71"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.380550861358643}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"S":["V511I"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"S: V511I; nsp1: G82-, H83-, V84-, M85V","spike_mutations":"V511I"}}}]},{"name":"NODE_0000212","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.277703762054443}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"nsp2":["K142R"]},"labels":{"aa":"nsp2: K142R"}},"children":[{"name":"GC.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"GC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9061"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.03073601411565"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.990260601043701}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"S":["T323I"],"nsp10":["F89L"]},"labels":{"aa":"S: T323I; nsp10: F89L","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.277703762054443}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000213","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.037090301513672}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.93"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.037090301513672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000214","node_attrs":{"div":103,"Nextclade_pango":{"value":"HD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"S":["T346I"],"nsp3":["T1462N"]},"labels":{"aa":"S: T346I; nsp3: T1462N","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7416800000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.73864"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.264838695526123}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"nsp5":["T93I"]},"labels":{"aa":"nsp5: T93I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.264838695526123}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":96,"Nextclade_pango":{"value":"HP.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"HP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.288678169250488}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"nsp3":["A1033V"]},"labels":{"aa":"nsp3: A1033V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.95"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.288678169250488}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000218","node_attrs":{"div":95,"Nextclade_pango":{"value":"HS.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"HS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.999259948730469}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.016602993011475}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1186099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"],"nsp2":["P129S"]},"labels":{"aa":"ORF3a: A31V, T269M; S: T284I, R403K, L513F; nsp2: P129S","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.693484306335449}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.512086391448975}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.016602993011475}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000220","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.372424125671387}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.372424125671387}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":96,"Nextclade_pango":{"value":"FZ.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}},{"name":"FZ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000222","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"HZ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"nsp6":["I124T"]},"labels":{"aa":"nsp6: I124T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000223","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"nsp5":["F223L"]},"labels":{"aa":"nsp5: F223L"}},"children":[{"name":"HZ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"HZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"nsp6":["H11Y"]},"labels":{"aa":"nsp6: H11Y"}}}]}]},{"name":"NODE_0000224","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"S":["Q146P","P631S"],"nsp3":["P1044S"],"nsp6":["T206A"]},"labels":{"aa":"S: Q146P, P631S; nsp3: P1044S; nsp6: T206A","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000225","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"nsp3":["G255V"]},"labels":{"aa":"nsp3: G255V"}},"children":[{"name":"HC.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"HC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"HC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"HC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"S":["D1084H"],"nsp3":["A534V","E1040K"]},"labels":{"aa":"S: D1084H; nsp3: A534V, E1040K","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000226","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.5769400596618652}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9873000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0346353162114479"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N417S"],"nsp1":["M85-"]},"labels":{"aa":"S: N417S; nsp1: M85-","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"EK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.174642086029053}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.5769400596618652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000227","node_attrs":{"div":99,"Nextclade_pango":{"value":"EK.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"S":["T259I"],"nsp6":["L260F"]},"labels":{"aa":"S: T259I; nsp6: L260F","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"EK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000228","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.045679092407227}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"HA.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"HA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"nsp4":["G105S"],"nsp6":["M143V"]},"labels":{"aa":"nsp4: G105S; nsp6: M143V"}}},{"name":"NODE_0000229","node_attrs":{"div":96,"Nextclade_pango":{"value":"EU.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C920T","C21910A"]}},"children":[{"name":"EU.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":98,"Nextclade_pango":{"value":"EU.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EU.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EU.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EU.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}}]}]}]},{"name":"NODE_0000231","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.344803810119629}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"GN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.837703704833984}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"GN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"nsp3":["L292I"],"nsp8":["S193F"]},"labels":{"aa":"nsp3: L292I; nsp8: S193F"}}},{"name":"GN.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"GN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"nsp8":["Q24L"]},"labels":{"aa":"nsp8: Q24L"}}},{"name":"XBB.1.5.73","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.344803810119629}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.668724536895752}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF3a":["G18V"],"nsp5":["T93I"]},"labels":{"aa":"ORF3a: G18V; nsp5: T93I"}},"children":[{"name":"GN.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000233","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.348021030426025}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.348021030426025}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"nsp14":["A119V"]},"labels":{"aa":"nsp14: A119V"}}},{"name":"GN.1.4","node_attrs":{"div":104,"Nextclade_pango":{"value":"GN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"GN.1.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"S":["L455F"],"nsp9":["P71T"]},"labels":{"aa":"S: L455F; nsp9: P71T","spike_mutations":"L455F"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.852011203765869}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.102"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.852011203765869}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":99,"Nextclade_pango":{"value":"JD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"nsp15":["H337Y"]},"labels":{"aa":"nsp15: H337Y"}},"children":[{"name":"JD.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"JD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"S":["E554K"],"nsp2":["G339S"]},"labels":{"aa":"S: E554K; nsp2: G339S","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":101,"Nextclade_pango":{"value":"JD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.622837066650391}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"JD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.622837066650391}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000237","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"JD.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF8":["A65V"],"S":["E554Q"],"nsp14":["D132E"]},"labels":{"aa":"N: P365L; ORF8: A65V; S: E554Q; nsp14: D132E","spike_mutations":"E554Q"}}},{"name":"JD.1.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":103,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.970474720001221}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"S":["A475V"],"nsp12":["A250V"]},"labels":{"aa":"S: A475V; nsp12: A250V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.970474720001221}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000239","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.197541236877441}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000240","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"nsp3":["N276K"]},"labels":{"aa":"nsp3: N276K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"KK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"S":["D1153H"],"nsp3":["D1122G"]},"labels":{"aa":"S: D1153H; nsp3: D1122G","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"KK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.20635"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2868306565498102"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000241","node_attrs":{"div":105,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.3283803462982178}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.4","node_attrs":{"div":110,"Nextclade_pango":{"value":"JD.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"JD.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1261900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3046787170970133"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF6":["N28D"],"S":["T470N"],"nsp3":["V766M"]},"labels":{"aa":"ORF6: N28D; S: T470N; nsp3: V766M","spike_mutations":"T470N"}}},{"name":"JD.1.1.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"nsp15":["R206S"]},"labels":{"aa":"nsp15: R206S"}}},{"name":"JD.1.1.5","node_attrs":{"div":110,"Nextclade_pango":{"value":"JD.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}}]}]}]}]}]},{"name":"NODE_0000242","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF8":["P38S"],"S":["L455F","F456L"],"nsp8":["A126S"]},"labels":{"aa":"ORF8: P38S; S: L455F, F456L; nsp8: A126S","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"S":["E554G"],"nsp13":["D105G"]},"labels":{"aa":"S: E554G; nsp13: D105G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.6","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.7"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.9"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.5.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000243","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"S":["E180K"],"nsp12":["T801I"]},"labels":{"aa":"S: E180K; nsp12: T801I","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"S":["N185I","A475V"],"nsp3":["N737S","I1192V"]},"labels":{"aa":"S: N185I, A475V; nsp3: N737S, I1192V","spike_mutations":"N185I, A475V"}}},{"name":"GK.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"S":["A475V"],"nsp12":["T319I"],"nsp4":["T96I"]},"labels":{"aa":"S: A475V; nsp12: T319I; nsp4: T96I","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"nsp3":["A58S"]},"labels":{"aa":"nsp3: A58S"}},"children":[{"name":"GK.3.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000247","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.4253100000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.12"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"S":["T76I","N450D"],"nsp3":["A1892T"],"nsp4":["M366I","P371S"]},"labels":{"aa":"S: T76I, N450D; nsp3: A1892T; nsp4: M366I, P371S","spike_mutations":"T76I, N450D"}}},{"name":"NODE_0000248","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.4","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.8981300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.8981300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"nsp12":["S772C"],"nsp2":["L444I"],"nsp6":["L72S"]},"labels":{"aa":"nsp12: S772C; nsp2: L444I; nsp6: L72S"}},"children":[{"name":"GK.2.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000250","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"nsp13":["D207G"],"nsp2":["R107G","E453A"]},"labels":{"aa":"nsp13: D207G; nsp2: R107G, E453A"}}},{"name":"GK.1.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"S":["S98F","K478R"],"nsp3":["A1561V"]},"labels":{"aa":"S: S98F, K478R; nsp3: A1561V","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"S":["F186L"],"nsp3":["T779I"]},"labels":{"aa":"S: F186L; nsp3: T779I","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}},{"name":"GK.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"GK.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"S":["A475V"],"nsp1":["D147G"],"nsp13":["N503K"],"nsp3":["D1774Y","V1897I"],"nsp9":["T35I"]},"labels":{"aa":"S: A475V; nsp1: D147G; nsp13: N503K; nsp3: D1774Y, V1897I; nsp9: T35I","spike_mutations":"A475V"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"S":["A475V"],"nsp2":["P129L"]},"labels":{"aa":"S: A475V; nsp2: P129L","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"S":["I68V"],"nsp14":["G265S"],"nsp3":["M1556L"]},"labels":{"aa":"S: I68V; nsp14: G265S; nsp3: M1556L","spike_mutations":"I68V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"S":["A475V"],"nsp1":["I114V"]},"labels":{"aa":"S: A475V; nsp1: I114V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":114,"Nextclade_pango":{"value":"GK.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"S":["A475V","E554K"],"nsp1":["L16F"],"nsp3":["G1389S","S1396L"]},"labels":{"aa":"S: A475V, E554K; nsp1: L16F; nsp3: G1389S, S1396L","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":114,"Nextclade_pango":{"value":"GK.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"GK.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF3a":["R134H"],"S":["K187I","A222P"],"nsp3":["P1228S"]},"labels":{"aa":"ORF3a: R134H; S: K187I, A222P; nsp3: P1228S","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000256","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF8":["A65V"],"ORF9b":["T95M"],"nsp2":["I393V"],"nsp8":["T187I"]},"labels":{"aa":"ORF8: A65V; ORF9b: T95M; nsp2: I393V; nsp8: T187I"}},"children":[{"name":"GK.1.10","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000257","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000258","node_attrs":{"div":114,"Nextclade_pango":{"value":"KN.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"KN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446400000000003"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3541583181563797"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"S":["L5F","N450D"],"nsp3":["T936I"]},"labels":{"aa":"S: L5F, N450D; nsp3: T936I","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000259","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-2.4134323596954346}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.106"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.106"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.2054524421691895}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"S":["A623V"],"nsp1":["V28I"],"nsp5":["R279H"]},"labels":{"aa":"S: A623V; nsp1: V28I; nsp5: R279H","spike_mutations":"A623V"}}},{"name":"XBB.1.5.20","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.20"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.6762609481811523}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.19","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.19"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062256813049316}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"nsp12":["R181C"]},"labels":{"aa":"nsp12: R181C"}}},{"name":"XBB.1.5.25","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.25"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.187304496765137}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.27"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.515915393829346}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"S":["K478R"],"nsp3":["E197G"]},"labels":{"aa":"S: K478R; nsp3: E197G","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.32"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.674532651901245}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"nsp4":["T60I"]},"labels":{"aa":"nsp4: T60I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.37"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.537872552871704}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.0984392166137695}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"S":["K1181I"],"nsp3":["S1428L"]},"labels":{"aa":"S: K1181I; nsp3: S1428L","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.56"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.201124668121338}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.60"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.624990940093994}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"S":["M177I"],"nsp3":["T1288I"]},"labels":{"aa":"S: M177I; nsp3: T1288I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.6"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.539541721343994}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.61"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265592575073242}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.65"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8307547569274902}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.74","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9630099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0169257119491577"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.74"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF8":["T11I"],"S":["K462R"],"nsp12":["V737I"]},"labels":{"aa":"ORF8: T11I; S: K462R; nsp12: V737I","spike_mutations":"K462R"}}},{"name":"XBB.1.5.72","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.72"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"S":["F456L"],"nsp2":["G265S"]},"labels":{"aa":"S: F456L; nsp2: G265S","spike_mutations":"F456L"}}},{"name":"XBB.1.5.76","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.76"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.102578639984131}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"nsp6":["T127A"]},"labels":{"aa":"nsp6: T127A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.78"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.389560222625732}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"nsp2":["N280D"]},"labels":{"aa":"nsp2: N280D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.81"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.81"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.628523826599121}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.449106693267822}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.83"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.83"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.545587539672852}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.84"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.84"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.249866485595703}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.89","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.89"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.89"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF7a":["T120I"],"S":["K478R","E554A"],"nsp4":["L106F"]},"labels":{"aa":"ORF7a: T120I; S: K478R, E554A; nsp4: L106F","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.88","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.88"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.88"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.301758766174316}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.9"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.153419494628906}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.91","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.91"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.91"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.224374771118164}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.90"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.90"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"S":["P621S"],"nsp15":["S261L"]},"labels":{"aa":"S: P621S; nsp15: S261L","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.94"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.94"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.96"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.96"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.111927032470703}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000260","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29580T"],"ORF10":["A8V"]},"labels":{"aa":"ORF10: A8V"}},"children":[{"name":"FD.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]},{"name":"NODE_0000261","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.786716938018799}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.786716938018799}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000262","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.83085"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000263","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"S":["P521T","V772I"],"nsp14":["V182I"]},"labels":{"aa":"S: P521T, V772I; nsp14: V182I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.83156"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9838451476656441"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.185719013214111}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.135186195373535}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.185719013214111}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.166083812713623}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"],"nsp3":["T619I"]},"labels":{"aa":"ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L; nsp3: T619I","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"KA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.103"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.166083812713623}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.184232234954834}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9350799999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"GB.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"GB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"S":["K478R"],"nsp3":["R646Q","A1818T"]},"labels":{"aa":"S: K478R; nsp3: R646Q, A1818T","spike_mutations":"K478R"}}},{"name":"XBB.1.5.46","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.184232234954834}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.094293594360352}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.094293594360352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000268","node_attrs":{"div":105,"Nextclade_pango":{"value":"HR.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF9b":["T95M"],"S":["K478R"],"nsp2":["G339S"],"nsp5":["V104I"],"nsp8":["T148I"]},"labels":{"aa":"N: I292V; ORF9b: T95M; S: K478R; nsp2: G339S; nsp5: V104I; nsp8: T148I","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"S":["K304N"],"nsp3":["A231V"],"nsp4":["D217N"]},"labels":{"aa":"S: K304N; nsp3: A231V; nsp4: D217N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.816721200942993}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"HT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.5930495262146}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"HT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.310773849487305}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.816721200942993}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000270","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000271","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF3a":["I63T"],"nsp3":["H1274Y"]},"labels":{"aa":"N: S26C; ORF3a: I63T; nsp3: H1274Y"}}}]},{"name":"NODE_0000272","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.5945"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JB.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.5945"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"nsp6":["M115T"]},"labels":{"aa":"nsp6: M115T"}},"children":[{"name":"FT.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FT.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"nsp2":["S358L"]},"labels":{"aa":"nsp2: S358L"}},"children":[{"name":"FT.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}},{"name":"FT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}}]},{"name":"internal_747c613f","node_attrs":{"div":96,"Nextclade_pango":{"value":"FT.3"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FT.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":100,"Nextclade_pango":{"value":"FT.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FT.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FT.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74638"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0924169334128189"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"internal_7eece817","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.800849199295044}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89299"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.800849199295044}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF7a":["P99L"],"ORF7b":["E3*"],"nsp3":["A655V"]},"labels":{"aa":"ORF7a: P99L; ORF7b: E3*; nsp3: A655V"}},"children":[{"name":"FD.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"S":["F456L"],"nsp9":["T34I"]},"labels":{"aa":"S: F456L; nsp9: T34I","spike_mutations":"F456L"}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"S":["Q146K"],"nsp2":["G339S"]},"labels":{"aa":"S: Q146K; nsp2: G339S","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"nsp4":["D259N"]},"labels":{"aa":"nsp4: D259N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.4"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"nsp9":["L51F"]},"labels":{"aa":"nsp9: L51F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FD.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"nsp10":["T102I"],"nsp16":["I237F"]},"labels":{"aa":"nsp10: T102I; nsp16: I237F"}}},{"name":"FD.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000281","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.78318452835083}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.25"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.561348915100098}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.26"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.213903903961182}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.213903903961182}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"nsp14":["H314N"],"nsp5":["P241L"]},"labels":{"aa":"nsp14: H314N; nsp5: P241L"}}},{"name":"NODE_0000283","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"nsp6":["L260F"]},"labels":{"aa":"nsp6: L260F"}},"children":[{"name":"HU.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"HU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF3a":["Q245R"],"S":["T76I"],"nsp1":["R24H"],"nsp13":["A505V"]},"labels":{"aa":"ORF3a: Q245R; S: T76I; nsp1: R24H; nsp13: A505V","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000284","node_attrs":{"div":98,"Nextclade_pango":{"value":"HU.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"HU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86018"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.950188045949472"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.67693"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9788766097021935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"S":["Q675K"],"nsp2":["D40E","C487Y"]},"labels":{"aa":"S: Q675K; nsp2: D40E, C487Y","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"S":["I197T"],"nsp13":["S74P"]},"labels":{"aa":"S: I197T; nsp13: S74P","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"S":["A684V"],"nsp3":["T1056I"]},"labels":{"aa":"S: A684V; nsp3: T1056I","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"nsp2":["A411V"]},"labels":{"aa":"nsp2: A411V"}},"children":[{"name":"FY.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FY.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF7b":["A15S"],"S":["S939F"],"nsp3":["T261S"]},"labels":{"aa":"ORF7b: A15S; S: S939F; nsp3: T261S","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF3a":["A103T"],"nsp4":["A380V"]},"labels":{"aa":"ORF3a: A103T; nsp4: A380V"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.8.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"S":["K478R"],"nsp14":["P158S"]},"labels":{"aa":"S: K478R; nsp14: P158S","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FY.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8926499999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"S":["P521Q"],"nsp13":["V226L"]},"labels":{"aa":"S: P521Q; nsp13: V226L","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"nsp2":["E570K"]},"labels":{"aa":"nsp2: E570K"}},"children":[{"name":"FY.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.86080265045166}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"S":["I210T"],"nsp3":["D464Y","T942I"]},"labels":{"aa":"S: I210T; nsp3: D464Y, T942I","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"nsp6":["E195G"]},"labels":{"aa":"nsp6: E195G"}}},{"name":"FY.3.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80106"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80106"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"nsp15":["V236I"],"nsp3":["Y1353F"]},"labels":{"aa":"nsp15: V236I; nsp3: Y1353F"}}},{"name":"NODE_0000294","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.4.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"nsp4":["S163F"]},"labels":{"aa":"nsp4: S163F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.5.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"S":["T572I"],"nsp3":["L865I"]},"labels":{"aa":"S: T572I; nsp3: L865I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"S":["M153I","F186S","S247N"],"nsp10":["V97I"]},"labels":{"aa":"S: M153I, F186S, S247N; nsp10: V97I","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"S":["T572I"],"nsp4":["D246N"],"nsp8":["Y135C"]},"labels":{"aa":"S: T572I; nsp4: D246N; nsp8: Y135C","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"nsp4":["M33I"]},"labels":{"aa":"nsp4: M33I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.5.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393481731414795}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"nsp14":["D258N"]},"labels":{"aa":"nsp14: D258N"}},"children":[{"name":"FY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393481731414795}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FY.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"S":["I569T"],"nsp14":["T131I"]},"labels":{"aa":"S: I569T; nsp14: T131I","spike_mutations":"I569T"}}}]},{"name":"NODE_0000301","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"S":["T572I"],"nsp12":["P227L"]},"labels":{"aa":"S: T572I; nsp12: P227L","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FY.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"S":["W64L"],"nsp3":["T779I"]},"labels":{"aa":"S: W64L; nsp3: T779I","spike_mutations":"W64L"}}},{"name":"internal_6436aedc","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000303","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-2.995669364929199}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"],"nsp14":["D222Y"],"nsp6":["L260F"]},"labels":{"aa":"ORF9b: N55S; S: E180V, K478R, S486P; nsp14: D222Y; nsp6: L260F","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-2.995669364929199}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.11"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.181058883666992}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.12"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.213220119476318}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.10","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.10"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7388600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.14"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.17"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.18"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.20"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.19","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.19"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"nsp12":["V848I"]},"labels":{"aa":"nsp12: V848I"}}},{"name":"XBB.1.16.23","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.23"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.350697994232178}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.21"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"nsp8":["V130I"]},"labels":{"aa":"nsp8: V130I"}}},{"name":"XBB.1.16.24","node_attrs":{"div":111,"Nextclade_pango":{"value":"XBB.1.16.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.24"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"S":["K182E","P521T","V551I","E554K"],"nsp2":["P568L"],"nsp3":["E154K"]},"labels":{"aa":"S: K182E, P521T, V551I, E554K; nsp2: P568L; nsp3: E154K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.22","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.22"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.469313621520996}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.28","node_attrs":{"div":107,"Nextclade_pango":{"value":"XBB.1.16.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.28"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"S":["Q613H","Q675K","V1230A"],"nsp3":["S176N"]},"labels":{"aa":"S: Q613H, Q675K, V1230A; nsp3: S176N","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.26","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.26"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.182722091674805}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.25","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.25"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"nsp2":["K330E"]},"labels":{"aa":"nsp2: K330E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":116,"Nextclade_pango":{"value":"XBB.1.16.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.27"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF3a":["M260T"],"S":["F456L","E554K"],"nsp3":["G145D","K1227R"],"nsp7":["A30T"]},"labels":{"aa":"ORF3a: M260T; S: F456L, E554K; nsp3: G145D, K1227R; nsp7: A30T","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.5","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.220455169677734}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.8"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.7","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.1.16.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.7"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"S":["T732I"],"nsp3":["Y272H"]},"labels":{"aa":"S: T732I; nsp3: Y272H","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.9"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.036108016967773}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"S":["F456L"],"nsp3":["S1682F"]},"labels":{"aa":"S: F456L; nsp3: S1682F","spike_mutations":"F456L"}}},{"name":"NODE_0000304","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64385"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF8":["F3L"],"S":["T573I"],"nsp3":["P841L"]},"labels":{"aa":"ORF8: F3L; S: T573I; nsp3: P841L","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64385"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000305","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"JM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"S":["Q52H"],"nsp2":["M418I"]},"labels":{"aa":"S: Q52H; nsp2: M418I","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000306","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.32681131362915}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":107,"Nextclade_pango":{"value":"XBB.1.16.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.29"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"S":["T883I"],"nsp14":["Y222D"],"nsp6":["L37F"]},"labels":{"aa":"S: T883I; nsp14: Y222D; nsp6: L37F","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.1.16.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.30"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.31"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"nsp2":["G339S"],"nsp3":["G283D"]},"labels":{"aa":"nsp2: G339S; nsp3: G283D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":106,"Nextclade_pango":{"value":"HF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.2","node_attrs":{"div":108,"Nextclade_pango":{"value":"HF.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.093987464904785}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"S":["A688V"],"nsp3":["P340S"]},"labels":{"aa":"S: A688V; nsp3: P340S","spike_mutations":"A688V"}}},{"name":"HF.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"HF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"HF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"S":["H1101Y"],"nsp12":["A185V"],"nsp13":["V305L"],"nsp3":["T1303I"]},"labels":{"aa":"N: A35T; S: H1101Y; nsp12: A185V; nsp13: V305L; nsp3: T1303I","spike_mutations":"H1101Y"}}}]}]},{"name":"NODE_0000309","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{}}},{"name":"internal_adf0d069","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.1121838092803955}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.3","node_attrs":{"div":112,"Nextclade_pango":{"value":"JF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"S":["Q14H","L455F","S810L"],"nsp2":["H237Y"],"nsp9":["D25G"]},"labels":{"aa":"S: Q14H, L455F, S810L; nsp2: H237Y; nsp9: D25G","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF8":["Q91H"],"S":["Q675H"],"nsp2":["E57D"]},"labels":{"aa":"ORF8: Q91H; S: Q675H; nsp2: E57D","spike_mutations":"Q675H"}}},{"name":"JF.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"JF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF8":["A15V"],"nsp2":["S32L"]},"labels":{"aa":"ORF8: A15V; nsp2: S32L"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000312","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"nsp3":["S1212L"]},"labels":{"aa":"nsp3: S1212L"}},"children":[{"name":"JF.1.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"JF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.2326700000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF10":["V30I"],"S":["A475V"],"nsp3":["P1187S"]},"labels":{"aa":"ORF10: V30I; S: A475V; nsp3: P1187S","spike_mutations":"A475V"}}},{"name":"JF.1.1.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"JF.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.14642"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"S":["K97E"],"nsp2":["R362C"]},"labels":{"aa":"S: K97E; nsp2: R362C","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"S":["E619Q"],"nsp3":["T1288N"]},"labels":{"aa":"S: E619Q; nsp3: T1288N","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.3"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000316","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000317","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FU.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"S":["N74S"],"nsp3":["A861V"]},"labels":{"aa":"S: N74S; nsp3: A861V","spike_mutations":"N74S"}}},{"name":"FU.1.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF3a":["V13L"],"nsp3":["P108H"]},"labels":{"aa":"ORF3a: V13L; nsp3: P108H"}},"children":[{"name":"GY.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"GY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8164899999999998"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.5","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"nsp3":["V947I"]},"labels":{"aa":"nsp3: V947I"}}},{"name":"GY.7","node_attrs":{"div":107,"Nextclade_pango":{"value":"GY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.7"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"nsp6":["G48C"]},"labels":{"aa":"nsp6: G48C"}}},{"name":"GY.8","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.8"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.9"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"GY.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000320","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"S":["L84I"],"nsp8":["A126S"]},"labels":{"aa":"S: L84I; nsp8: A126S","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"internal_4bba6217","node_attrs":{"div":108,"Nextclade_pango":{"value":"GY.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"GY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.2326700000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"S":["A475V"],"nsp2":["P96S"],"nsp3":["T133I","V245I"]},"labels":{"aa":"S: A475V; nsp2: P96S; nsp3: T133I, V245I","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.09637451171875}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.23"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000323","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000324","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"HL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"HL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"S":["S929N"],"nsp3":["P1132H"]},"labels":{"aa":"S: S929N; nsp3: P1132H","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.42.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.211273193359375}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"nsp3":["G1001S"]},"labels":{"aa":"nsp3: G1001S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.211273193359375}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.9.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"nsp2":["D449E"]},"labels":{"aa":"nsp2: D449E"}}},{"name":"XBB.1.9.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.9.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"S":["K478R","S486P"],"nsp3":["P200T","P1261S"]},"labels":{"aa":"S: K478R, S486P; nsp3: P200T, P1261S","spike_mutations":"K478R, S486P"}}},{"name":"XBB.1.9.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.9.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13558"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF7b":["H42Q"],"S":["R403K","A570T"],"nsp12":["T586A"],"nsp3":["A149V"]},"labels":{"aa":"ORF7b: H42Q; S: R403K, A570T; nsp12: T586A; nsp3: A149V","spike_mutations":"R403K, A570T"}}},{"name":"NODE_0000326","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"nsp14":["G44C","G481S"]},"labels":{"aa":"nsp14: G44C, G481S"}},"children":[{"name":"GD.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.331232070922852}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"GD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.068836212158203}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"GD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"S":["F59L"],"nsp8":["I185V"]},"labels":{"aa":"S: F59L; nsp8: I185V","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.9.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000327","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.3896050453186035}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.12","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.12"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.063467979431152}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"nsp3":["C1392F"]},"labels":{"aa":"nsp3: C1392F"}}},{"name":"FL.11","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF9b":["T60I"],"nsp2":["L169F"]},"labels":{"aa":"ORF9b: T60I; nsp2: L169F"}}},{"name":"FL.14","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.14"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.23352575302124}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.16"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.18","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0403361320495605}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"nsp3":["T1189I"]},"labels":{"aa":"nsp3: T1189I"}}},{"name":"FL.22","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.22"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.301856517791748}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"nsp13":["I493V"]},"labels":{"aa":"nsp13: I493V"}}},{"name":"FL.25","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.25"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.532011985778809}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.28","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.28"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF3a":["R68I"],"S":["K478R"],"nsp3":["S702F"]},"labels":{"aa":"ORF3a: R68I; S: K478R; nsp3: S702F","spike_mutations":"K478R"}}},{"name":"FL.27","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.27"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.406124591827393}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"nsp6":["V178I"]},"labels":{"aa":"nsp6: V178I"}}},{"name":"FL.29","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7904599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.29"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.6592278480529785}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"S":["S490P"],"nsp15":["I280V"]},"labels":{"aa":"S: S490P; nsp15: I280V","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.34"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.36"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"S":["R190S","K356T","T572I","A899S","A1070T"],"nsp7":["V66I"]},"labels":{"aa":"S: R190S, K356T, T572I, A899S, A1070T; nsp7: V66I","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.37"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.926265716552734}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.40"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.216498374938965}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"nsp6":["I189V"]},"labels":{"aa":"nsp6: I189V"}}},{"name":"FL.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.937436580657959}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"nsp3":["I31V"]},"labels":{"aa":"nsp3: I31V"}}},{"name":"FL.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.1645684242248535}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.511373996734619}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.411857604980469}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.3896050453186035}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000328","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C6285T","G12907A","A27507C","C28770T"],"N":["T166I"],"nsp3":["T1189I"]},"labels":{"aa":"N: T166I; nsp3: T1189I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.18.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"S":["Y200C","K478R"],"nsp12":["H650Q"],"nsp2":["G339S"]},"labels":{"aa":"S: Y200C, K478R; nsp12: H650Q; nsp2: G339S","spike_mutations":"Y200C, K478R"}}}]},{"name":"internal_d2a6176a","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.19"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"S":["F456L"],"nsp14":["A353V"]},"labels":{"aa":"S: F456L; nsp14: A353V","spike_mutations":"F456L"}}},{"name":"FL.19","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.24"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF3a":["N82S"],"S":["Q613H","A688V"],"nsp12":["I548V"]},"labels":{"aa":"ORF3a: N82S; S: Q613H, A688V; nsp12: I548V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"FL.24.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.26"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0848"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9957660361777405"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF3a":["T89I"],"S":["Q493L"],"nsp3":["E378V"]},"labels":{"aa":"ORF3a: T89I; S: Q493L; nsp3: E378V","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000332","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.30"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"S":["A484K"],"nsp1":["A79T"]},"labels":{"aa":"S: A484K; nsp1: A79T","spike_mutations":"A484K"}},"children":[{"name":"FL.30.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.30.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90046"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"FL.30","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90046"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"nsp13":["P504H"],"nsp15":["P262L"]},"labels":{"aa":"nsp13: P504H; nsp15: P262L"}}}]},{"name":"NODE_0000333","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.31"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"nsp12":["M666I"]},"labels":{"aa":"nsp12: M666I"}},"children":[{"name":"FL.31.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"],"nsp2":["A26V","C487Y"],"nsp3":["K233R"]},"labels":{"aa":"ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H; nsp2: A26V, C487Y; nsp3: K233R","spike_mutations":"D80H, K478R, Q613H"}}},{"name":"FL.31","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000334","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.32"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"S":["V6L","E554Q"],"nsp3":["V1538I"]},"labels":{"aa":"S: V6L, E554Q; nsp3: V1538I","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"S":["F456L"],"nsp15":["T114M"]},"labels":{"aa":"S: F456L; nsp15: T114M","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.33"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"nsp13":["A454V"]},"labels":{"aa":"nsp13: A454V"}},"children":[{"name":"FL.33.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.33.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.515425205230713}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.33","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_14b9e262","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.35"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.35.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917665958404541}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.39"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"nsp2":["E453K"]},"labels":{"aa":"nsp2: E453K"}},"children":[{"name":"FL.39","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"S":["K478R","P521S"],"nsp12":["T806I"],"nsp13":["P504S"]},"labels":{"aa":"S: K478R, P521S; nsp12: T806I; nsp13: P504S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000338","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9744794368743896}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9744794368743896}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000339","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.17"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"S":["N74H"],"nsp2":["L501F"],"nsp4":["G178D"]},"labels":{"aa":"S: N74H; nsp2: L501F; nsp4: G178D","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.97144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.17","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000340","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.20"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF3a":["L108F"],"S":["Q52H","F456L"],"nsp3":["I1192V"]},"labels":{"aa":"ORF3a: L108F; S: Q52H, F456L; nsp3: I1192V","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5920999999999998"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.20.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.21"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.21.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.21.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"nsp3":["V201F"],"nsp4":["I110M"]},"labels":{"aa":"nsp3: V201F; nsp4: I110M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.10"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"nsp2":["C477Y"]},"labels":{"aa":"nsp2: C477Y"}},"children":[{"name":"FL.10","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"FL.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.98073"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1216394663867173"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"],"nsp13":["N459S"],"nsp9":["G38S"]},"labels":{"aa":"N: K373N, D415E; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N; nsp13: N459S; nsp9: G38S","spike_mutations":"K356T, T523N"}}},{"name":"FL.10.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"internal_267c0772","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.23"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"nsp13":["V209I"]},"labels":{"aa":"nsp13: V209I"}},"children":[{"name":"FL.23.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"nsp3":["A1766V"]},"labels":{"aa":"nsp3: A1766V"}}},{"name":"FL.23","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000344","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"S":["Q146K","S494P"],"nsp15":["P205S"]},"labels":{"aa":"S: Q146K, S494P; nsp15: P205S","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.96117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.23.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8835"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000345","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"nsp3":["T1446I"]},"labels":{"aa":"nsp3: T1446I"}}},{"name":"FL.3.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"nsp10":["A32V"],"nsp2":["E592K"],"nsp4":["V235I"]},"labels":{"aa":"nsp10: A32V; nsp2: E592K; nsp4: V235I"}}},{"name":"FL.3.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.13"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.282327175140381}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.282327175140381}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"S":["A411S"],"nsp1":["P80S"],"nsp9":["T109I"]},"labels":{"aa":"S: A411S; nsp1: P80S; nsp9: T109I","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.13.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"S":["F456L"],"nsp3":["T182I","L1709M"]},"labels":{"aa":"S: F456L; nsp3: T182I, L1709M","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.13.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":35},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"S":["D178H"],"nsp13":["V187L"],"nsp3":["I187-","V188-","E189-","V190-","Q191-","P192-","Q193-","L194-","E195-","M196-","E197-","L198-","T199-","P200-","V201-","V202-","Q203-","T204-","I205-","E206-","V207-","N208-"],"nsp4":["T439M"]},"labels":{"aa":"S: D178H; nsp13: V187L; nsp3: I187-, V188-, E189-, V190-, Q191-, P192-, Q193-, L194-, E195-, M196-, E197-, L198-, T199-, P200-, V201-, V202-, Q203-, T204-, I205-, E206-, V207-, N208-; nsp4: T439M","spike_mutations":"D178H"}}},{"name":"FL.13.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.13.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.3.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"S":["E154Q"],"nsp3":["M84V"]},"labels":{"aa":"S: E154Q; nsp3: M84V","spike_mutations":"E154Q"}}}]},{"name":"internal_10382b90","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"S":["K182E","F456L"],"nsp3":["P841L"]},"labels":{"aa":"S: K182E, F456L; nsp3: P841L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.13.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"FL.13.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07635999999999983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"S":["Q14H","A484K"],"nsp12":["T803S"],"nsp3":["V1770L"],"nsp6":["F184V"]},"labels":{"aa":"S: Q14H, A484K; nsp12: T803S; nsp3: V1770L; nsp6: F184V","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.671235084533691}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"nsp2":["E457K"]},"labels":{"aa":"nsp2: E457K"}},"children":[{"name":"FL.38","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.38"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000351","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000352","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"nsp2":["G220V"]},"labels":{"aa":"nsp2: G220V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.15.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"internal_24b5ee08","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","C11747T","C29236T"]}}},{"name":"FL.15.4","node_attrs":{"div":103,"Nextclade_pango":{"value":"FL.15.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"nsp3":["S1367N"]},"labels":{"aa":"nsp3: S1367N"}}}]},{"name":"NODE_0000354","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G6819A","G22927T"],"S":["L455F"],"nsp3":["T1189I","S1367N"]},"labels":{"aa":"S: L455F; nsp3: T1189I, S1367N","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000355","node_attrs":{"div":110,"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"S":["A475V"],"nsp14":["G481S"],"nsp2":["A336G","Q395H"]},"labels":{"aa":"S: A475V; nsp14: G481S; nsp2: A336G, Q395H","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"FL.15.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000356","node_attrs":{"div":111,"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"KF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}},{"name":"KF.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"S":["P251H"],"nsp5":["T243I"]},"labels":{"aa":"S: P251H; nsp5: T243I","spike_mutations":"P251H"}}}]}]}]}]}]}]},{"name":"NODE_0000357","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.670197010040283}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"internal_fc124546","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"nsp13":["K460R"]},"labels":{"aa":"nsp13: K460R"}},"children":[{"name":"FL.2.3.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"FL.2.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"nsp3":["A1800T"]},"labels":{"aa":"nsp3: A1800T"}},"children":[{"name":"FL.2.7.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"S":["K478R"],"nsp6":["V149F"]},"labels":{"aa":"S: K478R; nsp6: V149F","spike_mutations":"K478R"}}},{"name":"FL.2.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000361","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"nsp13":["V169F"]},"labels":{"aa":"nsp13: V169F"}},"children":[{"name":"FL.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"S":["D1259Y"],"nsp3":["R352C"]},"labels":{"aa":"N: T334I; S: D1259Y; nsp3: R352C","spike_mutations":"D1259Y"}}},{"name":"FL.4.10","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.457831382751465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.775200128555298}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"S":["V289I"],"nsp3":["T133I"]},"labels":{"aa":"S: V289I; nsp3: T133I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"S":["K478T"],"nsp3":["T724I"]},"labels":{"aa":"S: K478T; nsp3: T724I","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.97144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0186868047371063"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3348299999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"S":["K478R"],"nsp3":["I1468T"]},"labels":{"aa":"S: K478R; nsp3: I1468T","spike_mutations":"K478R"}}}]},{"name":"NODE_0000364","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF8":["S67F"],"nsp3":["D410G"]},"labels":{"aa":"ORF8: S67F; nsp3: D410G"}}},{"name":"FL.4.6","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"S":["A701V"],"nsp3":["G175S"]},"labels":{"aa":"S: A701V; nsp3: G175S","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"nsp10":["T58I"]},"labels":{"aa":"nsp10: T58I"}}},{"name":"FL.1.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"nsp12":["M615I"],"nsp3":["T1063I"]},"labels":{"aa":"nsp12: M615I; nsp3: T1063I"}}},{"name":"FL.1.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"S":["K478R","P521T"],"nsp1":["P62S"],"nsp10":["K95R"],"nsp3":["T1482I"]},"labels":{"aa":"M: I8V; S: K478R, P521T; nsp1: P62S; nsp10: K95R; nsp3: T1482I","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"nsp16":["Q238P"]},"labels":{"aa":"nsp16: Q238P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FL.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"S":["A688S"],"nsp4":["S34F"]},"labels":{"aa":"S: A688S; nsp4: S34F","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89211"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9778643306477401"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.538186073303223}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"S":["F456L"],"nsp16":["K160R"]},"labels":{"aa":"S: F456L; nsp16: K160R","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.538186073303223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000369","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.06800999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000370","node_attrs":{"div":109,"Nextclade_pango":{"value":"KC.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"S":["S490P"],"nsp2":["S543F"],"nsp8":["T187I"]},"labels":{"aa":"S: S490P; nsp2: S543F; nsp8: T187I","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"KC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.15393000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"KC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.15393000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000371","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"S":["K478R"],"nsp15":["S147I"]},"labels":{"aa":"S: K478R; nsp15: S147I","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"nsp3":["D1115A"]},"labels":{"aa":"nsp3: D1115A"}}},{"name":"HN.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"HN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000372","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF9b":["G31E"],"nsp2":["T223I"]},"labels":{"aa":"ORF9b: G31E; nsp2: T223I"}},"children":[{"name":"HN.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":112,"Nextclade_pango":{"value":"HN.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000373","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"HN.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0007299999999998658"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3005141566416802"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}},{"name":"HN.4.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000374","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.123271942138672}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.8","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"nsp3":["E1224D"]},"labels":{"aa":"nsp3: E1224D"}}},{"name":"HN.7","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.777099132537842}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"NODE_0000375","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"nsp12":["P232S"]},"labels":{"aa":"nsp12: P232S"}},"children":[{"name":"HN.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000376","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.009539999999999936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.009539999999999936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"S":["D253G"],"nsp2":["G165C"]},"labels":{"aa":"S: D253G; nsp2: G165C","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000377","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.619708299636841}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.12"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF3a":["S40L"],"S":["Q146K","E554K"],"nsp9":["T19I"]},"labels":{"aa":"N: R195T; ORF3a: S40L; S: Q146K, E554K; nsp9: T19I","spike_mutations":"Q146K, E554K"}}},{"name":"EG.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"nsp2":["K618N"]},"labels":{"aa":"nsp2: K618N"}}},{"name":"EG.14","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.14"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF3a":["A54V"],"nsp13":["K460R"]},"labels":{"aa":"ORF3a: A54V; nsp13: K460R"}}},{"name":"EG.7","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1186099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"S":["R403K","L513F"],"nsp14":["A138V"],"nsp3":["N1713S"]},"labels":{"aa":"S: R403K, L513F; nsp14: A138V; nsp3: N1713S","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"nsp3":["S1485F"]},"labels":{"aa":"nsp3: S1485F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.619708299636841}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.9"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"S":["R403K"],"nsp13":["N46S"],"nsp3":["T656I"]},"labels":{"aa":"S: R403K; nsp13: N46S; nsp3: T656I","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.20938"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17686"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.10"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17686"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000380","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"S":["S494P","A701V"],"nsp1":["R24C"]},"labels":{"aa":"S: S494P, A701V; nsp1: R24C","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1256300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.10.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1256300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0006818771362305}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"nsp14":["P46S"],"nsp3":["V1885L"],"nsp6":["V114I"]},"labels":{"aa":"nsp14: P46S; nsp3: V1885L; nsp6: V114I"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.6"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000382","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.6.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}},{"name":"EG.6.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.6.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07635999999999983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"S":["L242I","A484K"],"nsp14":["R52K"],"nsp3":["P968L"]},"labels":{"aa":"S: L242I, A484K; nsp14: R52K; nsp3: P968L","spike_mutations":"L242I, A484K"}}}]}]},{"name":"NODE_0000383","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"S":["K304N"],"nsp2":["A522V"]},"labels":{"aa":"N: R204P; S: K304N; nsp2: A522V","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"S":["I742V"],"nsp13":["I370V"],"nsp2":["K142R"]},"labels":{"aa":"S: I742V; nsp13: I370V; nsp2: K142R","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"S":["K356T"],"nsp3":["G1447D"]},"labels":{"aa":"S: K356T; nsp3: G1447D","spike_mutations":"K356T"}}},{"name":"EG.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF3a":["H243R"],"S":["V327I","F456L"],"nsp14":["R98I"],"nsp3":["Y816H"]},"labels":{"aa":"ORF3a: H243R; S: V327I, F456L; nsp14: R98I; nsp3: Y816H","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"nsp12":["H882Y"],"nsp3":["Y647C"]},"labels":{"aa":"nsp12: H882Y; nsp3: Y647C"}}},{"name":"EG.4.5","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"nsp4":["L15F"]},"labels":{"aa":"nsp4: L15F"}}},{"name":"NODE_0000386","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"S":["V70F","I312V"],"nsp2":["T223I"]},"labels":{"aa":"S: V70F, I312V; nsp2: T223I","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"S":["S640F"],"nsp12":["D170G"],"nsp15":["P270L"]},"labels":{"aa":"S: S640F; nsp12: D170G; nsp15: P270L","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"nsp3":["S1682F"]},"labels":{"aa":"nsp3: S1682F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF3a":["F114V","D199E"],"S":["P217L"],"nsp12":["N874K"],"nsp3":["P1103L","A1461T"]},"labels":{"aa":"ORF3a: F114V, D199E; S: P217L; nsp12: N874K; nsp3: P1103L, A1461T","spike_mutations":"P217L"}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.697697162628174}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF10":["S23F"],"S":["F456L"],"nsp2":["A510V"],"nsp4":["A380V"]},"labels":{"aa":"ORF10: S23F; S: F456L; nsp2: A510V; nsp4: A380V","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000389","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"nsp12":["T248I"]},"labels":{"aa":"nsp12: T248I"}}},{"name":"NODE_0000390","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF3a":["I118V"],"nsp3":["H295Y","N1337S"]},"labels":{"aa":"ORF3a: I118V; nsp3: H295Y, N1337S"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.5.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"EG.5.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000391","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.3748607635498047}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.3748607635498047}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.13","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.12","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.10","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.850919246673584}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"nsp6":["I189V"]},"labels":{"aa":"nsp6: I189V"}}},{"name":"EG.5.1.15","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.343207836151123}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"nsp2":["T573I"]},"labels":{"aa":"nsp2: T573I"}}},{"name":"EG.5.1.17","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.16","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"nsp16":["A34V"]},"labels":{"aa":"nsp16: A34V"}}},{"name":"EG.5.1.14","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"nsp14":["V120I"]},"labels":{"aa":"nsp14: V120I"}}},{"name":"EG.5.1.19","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.18","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF3a":["S220I"],"nsp4":["G239S"]},"labels":{"aa":"ORF3a: S220I; nsp4: G239S"}}},{"name":"EG.5.1.7","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.3128533363342285}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.5","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.5.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"nsp13":["T351I"],"nsp15":["L298V"],"nsp5":["L30I"]},"labels":{"aa":"nsp13: T351I; nsp15: L298V; nsp5: L30I"}}},{"name":"EG.5.1.9","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"S":["L176F"],"nsp3":["D164G"]},"labels":{"aa":"S: L176F; nsp3: D164G","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.377831935882568}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":106,"Nextclade_pango":{"value":"JR.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"JR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000395","node_attrs":{"div":111,"Nextclade_pango":{"value":"JR.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"S":["L455F","K478R"],"nsp16":["G113C"],"nsp2":["L270F"]},"labels":{"aa":"S: L455F, K478R; nsp16: G113C; nsp2: L270F","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"JR.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.73257"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4312755323086508"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"S":["K356Q"],"nsp4":["A298V"]},"labels":{"aa":"S: K356Q; nsp4: A298V","spike_mutations":"K356Q"}}},{"name":"JR.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"JR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000396","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"KB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"internal_b60a1521","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"NODE_0000398","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"nsp2":["R362C"]},"labels":{"aa":"nsp2: R362C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000399","node_attrs":{"div":109,"Nextclade_pango":{"value":"JG.3"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"S":["L455F","S704L"],"nsp3":["T1456I"]},"labels":{"aa":"S: L455F, S704L; nsp3: T1456I","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"JG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"JG.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF3a":["L140F"],"S":["T307I"],"nsp3":["S1738L"]},"labels":{"aa":"ORF3a: L140F; S: T307I; nsp3: S1738L","spike_mutations":"T307I"}}},{"name":"JG.3.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"JG.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.4253100000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.8458521366119385}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.3","node_attrs":{"div":111,"Nextclade_pango":{"value":"JG.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3.4","node_attrs":{"div":112,"Nextclade_pango":{"value":"JG.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.12369441986084}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000400","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.735776662826538}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"S":["F157L"],"nsp3":["S1039L"]},"labels":{"aa":"S: F157L; nsp3: S1039L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.735776662826538}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"HV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000401","node_attrs":{"div":109,"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.068493127822876}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1.10","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.025979999999999802"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.068493127822876}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"HV.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21974"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3005451981781486"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.11","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0887599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3341105633249508"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.31048583984375}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.5","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.4","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.7","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"HV.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.8","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"S":["T208M"],"nsp2":["T166I"]},"labels":{"aa":"S: T208M; nsp2: T166I","spike_mutations":"T208M"}}},{"name":"internal_2378868c","node_attrs":{"div":110,"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}},"children":[{"name":"HV.1.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.38161000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3552393372267753"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}},{"name":"HV.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.048559999999999943"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000403","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"nsp3":["T976I","P1200S"]},"labels":{"aa":"nsp3: T976I, P1200S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000404","node_attrs":{"div":114,"Nextclade_pango":{"value":"HV.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"HV.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000405","node_attrs":{"div":115,"Nextclade_pango":{"value":"KL.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"KL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.008039999999999839"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"KL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.008039999999999839"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF3a":["S40P"],"S":["H1101Y"],"nsp14":["Q354H"]},"labels":{"aa":"ORF3a: S40P; S: H1101Y; nsp14: Q354H","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000406","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"nsp12":["D63N"]},"labels":{"aa":"nsp12: D63N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13706999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1972306507819483"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.19","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.508697986602783}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.21","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.1481699999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.205901853206978"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.49366"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.310148541751831"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF3a":["M5I"],"S":["L452Q","L455F"],"nsp14":["R98K"]},"labels":{"aa":"ORF3a: M5I; S: L452Q, L455F; nsp14: R98K","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":125,"Nextclade_pango":{"value":"HK.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"],"nsp2":["P129L"],"nsp3":["H323Y","E1294D"],"nsp6":["V182F"]},"labels":{"aa":"N: P365L; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R; nsp2: P129L; nsp3: H323Y, E1294D; nsp6: V182F","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"nsp3":["G1691D"]},"labels":{"aa":"nsp3: G1691D"}}},{"name":"HK.31","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"nsp2":["G424S"]},"labels":{"aa":"nsp2: G424S"}}},{"name":"HK.32","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.30","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"S":["T307I","L455F"],"nsp3":["V1201I"]},"labels":{"aa":"S: T307I, L455F; nsp3: V1201I","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.11"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}},{"name":"HK.11.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.2"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.20"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"S":["L455F"],"nsp3":["P1326S"]},"labels":{"aa":"S: L455F; nsp3: P1326S","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.6088199999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2183176254438959"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.24"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.23"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000413","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"S":["L455F"],"nsp4":["T143N"]},"labels":{"aa":"S: L455F; nsp4: T143N","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"HK.23.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.48614000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3534097328298118"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"S":["A348S"],"nsp15":["G146D"],"nsp2":["G88W","E162G","D286N"]},"labels":{"aa":"S: A348S; nsp15: G146D; nsp2: G88W, E162G, D286N","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"S":["D253G"],"nsp3":["A1105T"]},"labels":{"aa":"S: D253G; nsp3: A1105T","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.26"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.919094562530518}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.27"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"nsp3":["T771I"]},"labels":{"aa":"nsp3: T771I"}},"children":[{"name":"HK.27","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000417","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.27.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.27.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.34"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"S":["F186S"],"nsp6":["V91M"]},"labels":{"aa":"S: F186S; nsp6: V91M","spike_mutations":"F186S"}},"children":[{"name":"HK.34.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.34","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.13"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.202107906341553}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000421","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"HK.13.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"S":["T250I"],"nsp10":["A104V"],"nsp13":["T255A"]},"labels":{"aa":"N: T379I; S: T250I; nsp10: A104V; nsp13: T255A","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.15","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"S":["A262T"],"nsp3":["Q173R"]},"labels":{"aa":"S: A262T; nsp3: Q173R","spike_mutations":"A262T"}}},{"name":"HK.16","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.089319229125977}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.3"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.12","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.10","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.13","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.741406440734863}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"S":["A475V"],"nsp15":["I327T"]},"labels":{"aa":"S: A475V; nsp15: I327T","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.4","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"S":["P809S"],"nsp2":["T160I"]},"labels":{"aa":"S: P809S; nsp2: T160I","spike_mutations":"P809S"}}},{"name":"HK.3.5","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"S":["P174S"],"nsp3":["E392K"]},"labels":{"aa":"S: P174S; nsp3: E392K","spike_mutations":"P174S"}}},{"name":"HK.3.7","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.6","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.8","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"S":["E554K"],"nsp12":["T252N"]},"labels":{"aa":"S: E554K; nsp12: T252N","spike_mutations":"E554K"}}},{"name":"NODE_0000425","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.2"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF8":["A55T"],"S":["Q677H"],"nsp1":["E148A"],"nsp15":["T325I"],"nsp2":["T434I"]},"labels":{"aa":"ORF8: A55T; S: Q677H; nsp1: E148A; nsp15: T325I; nsp2: T434I","spike_mutations":"Q677H"}}},{"name":"HK.3.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.2","node_attrs":{"div":118,"Nextclade_pango":{"value":"HK.3.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"],"nsp3":["G1524E"]},"labels":{"aa":"ORF3a: I35T; ORF8: M1L; S: N185D; nsp3: G1524E","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000426","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.3","node_attrs":{"div":2,"Nextclade_pango":{"value":"B.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.3"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.030364513397217}},"branch_attrs":{"mutations":{"nuc":["G1440A","G2891A"],"nsp2":["G212D"],"nsp3":["A58T"]},"labels":{"aa":"nsp2: G212D; nsp3: A58T"}}},{"name":"B.23","node_attrs":{"div":2,"Nextclade_pango":{"value":"B.23"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.23"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.471245765686035}},"branch_attrs":{"mutations":{"nuc":["A1605-","T1606-","G1607-","C20270T","C29870A"],"nsp15":["A217V"],"nsp2":["D268-"]},"labels":{"aa":"nsp15: A217V; nsp2: D268-"}}},{"name":"B.55","node_attrs":{"div":1,"Nextclade_pango":{"value":"B.55"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.55"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.3334856033325195}},"branch_attrs":{"mutations":{"nuc":["T514C"]}}},{"name":"NODE_0000427","node_attrs":{"div":1,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.376059532165527}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"B.4","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.4"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.114971160888672}},"branch_attrs":{"mutations":{"nuc":["G1397A","T28688C","G29742T"],"nsp2":["V198I"]},"labels":{"aa":"nsp2: V198I"}}},{"name":"NODE_0000428","node_attrs":{"div":3,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.5978965759277344}},"branch_attrs":{"mutations":{"nuc":["C14805T","G26144T"],"ORF3a":["G251V"]},"labels":{"aa":"ORF3a: G251V"}},"children":[{"name":"B.39","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.39"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.39"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["A1515G","C9223T","T17247C"],"nsp2":["H237R"]},"labels":{"aa":"nsp2: H237R"}}},{"name":"B.40","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.40"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.40"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.6938891410827637}},"branch_attrs":{"mutations":{"nuc":["A2480G","C2558T"],"nsp2":["I559V","P585S"]},"labels":{"aa":"nsp2: I559V, P585S"}}}]},{"name":"NODE_0000429","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.6"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{"nuc":["C6312A","C13730T","C23929T","C28311T"],"N":["P13L"],"ORF9b":["P10S"],"nsp12":["A97V"],"nsp3":["T1198K"]},"labels":{"aa":"N: P13L; ORF9b: P10S; nsp12: A97V; nsp3: T1198K"}},"children":[{"name":"B.6","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.6"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{}}},{"name":"B.6.6","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.6.6"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.402256011962891}},"branch_attrs":{"mutations":{"nuc":["C6310A","C19524T"],"nsp3":["S1197R"]},"labels":{"aa":"nsp3: S1197R"}}}]}]},{"name":"NODE_0000430","node_attrs":{"div":3,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.371846675872803}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S","clade":"19B"}},"children":[{"name":"A.1","node_attrs":{"div":6,"Nextclade_pango":{"value":"A.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-3.6224653720855713}},"branch_attrs":{"mutations":{"nuc":["C17747T","A17858G","C18060T"],"nsp13":["P504L","Y541C"]},"labels":{"aa":"nsp13: P504L, Y541C"}}},{"name":"A","node_attrs":{"div":3,"Nextclade_pango":{"value":"A"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.371846675872803}},"branch_attrs":{"mutations":{}}},{"name":"A.5","node_attrs":{"div":4,"Nextclade_pango":{"value":"A.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.451474189758301}},"branch_attrs":{"mutations":{"nuc":["C26088T"]}}},{"name":"A.3","node_attrs":{"div":13,"Nextclade_pango":{"value":"A.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.3"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.0400519371032715}},"branch_attrs":{"mutations":{"nuc":["T490A","C3177T","C6040T","G12478A","T18736C","C24034T","T26729C","G28077C","C28896G","A29700G"],"N":["A208G"],"ORF8":["V62L"],"nsp1":["D75E"],"nsp14":["F233L"],"nsp3":["P153L"],"nsp8":["M129I"]},"labels":{"aa":"N: A208G; ORF8: V62L; nsp1: D75E; nsp14: F233L; nsp3: P153L; nsp8: M129I"}}},{"name":"NODE_0000431","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.2"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["T9477A","C14805T","G25979T","C28657T","C28863T"],"N":["S197L"],"ORF3a":["G196V"],"nsp4":["F308Y"]},"labels":{"aa":"N: S197L; ORF3a: G196V; nsp4: F308Y"}},"children":[{"name":"A.2","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000432","node_attrs":{"div":27,"Nextclade_pango":{"value":"A.2.5"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{"nuc":["C275T","C1567T","C4543T","A5234G","A5488G","C10029T","C11005A","C12815T","C16466T","T16857C","T18417C","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T22917G","A23403G","G24697A","C25613T","C26681T","A28272T","G28975T","C29421T"],"N":["M234I","P383L"],"ORF3a":["S74F"],"S":["L141-","G142-","V143-","L452R","D614G"],"nsp1":["L4F"],"nsp13":["P77L"],"nsp3":["K839E"],"nsp4":["T492I"],"nsp6":["H11Q"]},"labels":{"aa":"N: M234I, P383L; ORF3a: S74F; S: L141-, G142-, V143-, L452R, D614G; nsp1: L4F; nsp13: P77L; nsp3: K839E; nsp4: T492I; nsp6: H11Q","spike_mutations":"L141-, G142-, V143-, L452R, D614G"}},"children":[{"name":"A.2.5","node_attrs":{"div":27,"Nextclade_pango":{"value":"A.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{}}},{"name":"A.2.5.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"A.2.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.212984561920166}},"branch_attrs":{"mutations":{"nuc":["T15326C","A22525G","G27706T"],"ORF7a":["A105S"],"nsp12":["M629T"]},"labels":{"aa":"ORF7a: A105S; nsp12: M629T"}}},{"name":"A.2.5.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"A.2.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.277773380279541}},"branch_attrs":{"mutations":{"nuc":["C1722T","C29366T"],"N":["P365S"],"nsp2":["A306V"]},"labels":{"aa":"N: P365S; nsp2: A306V"}}},{"name":"A.2.5.3","node_attrs":{"div":30,"Nextclade_pango":{"value":"A.2.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.3"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["G2272A","G22992A","C29870A"],"S":["S477N"]},"labels":{"aa":"S: S477N","spike_mutations":"S477N"}}}]}]},{"name":"internal_446d","node_attrs":{"div":5,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.395915508270264}},"branch_attrs":{"mutations":{"nuc":["G28878A","G29742A"],"N":["S202N"]},"labels":{"aa":"N: S202N"}},"children":[{"name":"A.18","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.18"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.22163200378418}},"branch_attrs":{"mutations":{"nuc":["A3234T","C15126T","A23403G","C27812T"],"S":["D614G"],"nsp3":["Q172L"]},"labels":{"aa":"S: D614G; nsp3: Q172L","spike_mutations":"D614G"}}},{"name":"A.21","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.21"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.21"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C10138T","G11417T","G23402A","G25687T"],"ORF3a":["A99S"],"S":["D614N"],"nsp6":["V149F"]},"labels":{"aa":"ORF3a: A99S; S: D614N; nsp6: V149F","spike_mutations":"D614N"}}},{"name":"NODE_0000434","node_attrs":{"div":6,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22468T"]}},"children":[{"name":"A.28","node_attrs":{"div":20,"Nextclade_pango":{"value":"A.28"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.28"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A481G","G521T","C2197T","G10850A","C12469T","C16391T","G17014T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A23064C","C23525T","C25904T","C27294T","A27489G","A28272T","C28377T"],"N":["A35V"],"ORF3a":["S171L"],"ORF9b":["R32C"],"S":["H69-","V70-","N501T","H655Y"],"nsp1":["V86F"],"nsp13":["A52V","D260Y"],"nsp5":["A266T"]},"labels":{"aa":"N: A35V; ORF3a: S171L; ORF9b: R32C; S: H69-, V70-, N501T, H655Y; nsp1: V86F; nsp13: A52V, D260Y; nsp5: A266T","spike_mutations":"H69-, V70-, N501T, H655Y"}}},{"name":"NODE_0000435","node_attrs":{"div":7,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A361G"]}},"children":[{"name":"A.19","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.19"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.19"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12820G","A23403G"],"S":["D614G"]},"labels":{"aa":"S: D614G","spike_mutations":"D614G"}}},{"name":"A.27","node_attrs":{"div":24,"Nextclade_pango":{"value":"A.27"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.27"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C1122T","C2509T","A9204G","A11217G","C16466T","A18366G","A20262G","C21614T","T22917G","A23063T","C23520T","C23525T","G23948T","G25218T","T25541C","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","C27247T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28273T"],"ORF3a":["V50A","N257-","P258-"],"ORF8":["D119-","F120-"],"S":["L18F","L452R","N501Y","A653V","H655Y","D796Y","G1219V"],"nsp13":["P77L"],"nsp2":["P106L"],"nsp4":["D217G"],"nsp6":["N82S"]},"labels":{"aa":"ORF3a: V50A, N257-, P258-; ORF8: D119-, F120-; S: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V; nsp13: P77L; nsp2: P106L; nsp4: D217G; nsp6: N82S","spike_mutations":"L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V"}}}]}]},{"name":"NODE_0000436","node_attrs":{"div":7,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.347469329833984}},"branch_attrs":{"mutations":{"nuc":["G11230T","G28167A"],"ORF8":["E92K"],"nsp6":["M86I"]},"labels":{"aa":"ORF8: E92K; nsp6: M86I"}},"children":[{"name":"A.25","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.25"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.25"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5544T"],"nsp3":["T942I"]},"labels":{"aa":"nsp3: T942I"}}},{"name":"A.29","node_attrs":{"div":24,"Nextclade_pango":{"value":"A.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"S:142-143"},"designation_date":{"value":"2021-05-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.29"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G521T","C2110T","C8605T","C9891T","C12970T","G17964T","A19426G","A21069G","G21255T","T21982-","T21983-","T21984-","G21985-","T21992-","A21993-","A22194-","T22195-","T22196-","T22907C","A23063T","T23255C","C23525T","T26767G","G27604T","A28271-","G28337T","C29739T"],"M":["I82S"],"N":["D22Y"],"ORF7a":["V71L"],"ORF9b":["Q18H"],"S":["F140-","L141-","Y144-","N211-","L212I","Y449H","N501Y","F565L","H655Y"],"nsp1":["V86F"],"nsp13":["M576I"],"nsp14":["I463V"],"nsp4":["A446V"]},"labels":{"aa":"M: I82S; N: D22Y; ORF7a: V71L; ORF9b: Q18H; S: F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y; nsp1: V86F; nsp13: M576I; nsp14: I463V; nsp4: A446V","spike_mutations":"F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y"}}},{"name":"NODE_0000437","node_attrs":{"div":18,"Nextclade_pango":{"value":"A.23"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C4573T","C10747T","G11266T","C16575T","C17745T","C22000T","C22033A","G22661T","G23401T","T24097C","G28378C"],"ORF9b":["R32P"],"S":["F157L","V367F","Q613H"],"nsp6":["L98F"]},"labels":{"aa":"ORF9b: R32P; S: F157L, V367F, Q613H; nsp6: L98F","spike_mutations":"F157L, V367F, Q613H"}},"children":[{"name":"A.23.1","node_attrs":{"div":20,"Nextclade_pango":{"value":"A.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["G11521T","C23604G"],"S":["P681R"],"nsp6":["M183I"]},"labels":{"aa":"S: P681R; nsp6: M183I","spike_mutations":"P681R"}}},{"name":"A.23","node_attrs":{"div":18,"Nextclade_pango":{"value":"A.23"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000438","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C14408T","A23403G"],"S":["D614G"],"nsp12":["P323L"]},"labels":{"aa":"S: D614G; nsp12: P323L","clade":"20A","spike_mutations":"D614G"}},"children":[{"name":"B.1","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{}}},{"name":"B.1.128","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.128"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.128"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9753756523132324}},"branch_attrs":{"mutations":{"nuc":["C8293T","T18488C","T24739C","A26530G"],"M":["D3G"],"nsp14":["I150T"]},"labels":{"aa":"M: D3G; nsp14: I150T"}}},{"name":"B.1.143","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.143"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.143"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.877503871917725}},"branch_attrs":{"mutations":{"nuc":["C4084T"]}}},{"name":"B.1.126","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.126"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.126"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.10439395904541}},"branch_attrs":{"mutations":{"nuc":["T3011C","G22205T","T27869C","T28853G"],"N":["S194A"],"S":["D215Y"]},"labels":{"aa":"N: S194A; S: D215Y","spike_mutations":"D215Y"}}},{"name":"B.1.179","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.179"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.179"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.580779075622559}},"branch_attrs":{"mutations":{"nuc":["C7834T"]}}},{"name":"B.1.195","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.195"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.195"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.6570916175842285}},"branch_attrs":{"mutations":{"nuc":["A1T","A6466G"]}}},{"name":"B.1.206","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.206"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.206"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.032977104187012}},"branch_attrs":{"mutations":{"nuc":["G2282A","T9742C","C17639T"],"nsp13":["S468L"],"nsp2":["E493K"]},"labels":{"aa":"nsp13: S468L; nsp2: E493K"}}},{"name":"B.1.22","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.22"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.218311786651611}},"branch_attrs":{"mutations":{"nuc":["C1594T","C11109T","G25563T"],"ORF3a":["Q57H"],"nsp6":["A46V"]},"labels":{"aa":"ORF3a: Q57H; nsp6: A46V"}}},{"name":"B.1.222","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.222"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.222"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.235558032989502}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.247","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1.247"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.247"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{}}},{"name":"B.1.260","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.260"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.260"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.373620986938477}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}}},{"name":"B.1.379","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.379"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.379"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.878320217132568}},"branch_attrs":{"mutations":{"nuc":["A11782G"]}}},{"name":"B.1.377","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.377"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.377"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.68954610824585}},"branch_attrs":{"mutations":{"nuc":["G28300T","G28883A","A28998G"],"N":["Q9H","G204R","Q242R"],"ORF9b":["S6I"]},"labels":{"aa":"N: Q9H, G204R, Q242R; ORF9b: S6I"}}},{"name":"B.1.380","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.380"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.380"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.045155048370361}},"branch_attrs":{"mutations":{"nuc":["C7420T","C12439T","T26017G"],"ORF3a":["S209A"]},"labels":{"aa":"ORF3a: S209A"}}},{"name":"B.1.391","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.391"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.391"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.035617351531982}},"branch_attrs":{"mutations":{"nuc":["C16289T","G25429T"],"ORF3a":["V13L"],"nsp13":["A18V"]},"labels":{"aa":"ORF3a: V13L; nsp13: A18V"}}},{"name":"B.1.393","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.393"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.393"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.217160701751709}},"branch_attrs":{"mutations":{"nuc":["A5040G","G29477T","C29774T"],"N":["D402Y"],"nsp3":["Q774R"]},"labels":{"aa":"N: D402Y; nsp3: Q774R"}}},{"name":"B.1.395","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.395"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.395"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.251682281494141}},"branch_attrs":{"mutations":{"nuc":["C6990T"],"nsp3":["S1424F"]},"labels":{"aa":"nsp3: S1424F"}}},{"name":"B.1.411","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.411"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.411"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.553277492523193}},"branch_attrs":{"mutations":{"nuc":["C1519T","A14774G","G15438T","T16062C","G17334T","C25037T","C27945T"],"ORF8":["Q18*"],"S":["H1159Y"],"nsp12":["D445G","M666I"]},"labels":{"aa":"ORF8: Q18*; S: H1159Y; nsp12: D445G, M666I","spike_mutations":"H1159Y"}}},{"name":"B.1.524","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.524"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.524"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C6312T","C8637T","A10124G","C17518T","C21516T","C21622A","C23664T","A28133T","C28854T"],"N":["S194L"],"S":["A701V"],"nsp13":["L428F"],"nsp3":["T1198I"],"nsp4":["T28I"],"nsp5":["T24A"]},"labels":{"aa":"N: S194L; S: A701V; nsp13: L428F; nsp3: T1198I; nsp4: T28I; nsp5: T24A","spike_mutations":"A701V"}}},{"name":"B.1.525","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.525"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Eta"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21D (Eta)"},"partiallyAliased":{"value":"B.1.525"},"clade_nextstrain":{"value":"21D"},"clade_membership":{"value":"21D"},"placement_prior":{"value":-3.2125132083892822}},"branch_attrs":{"mutations":{"nuc":["C1498T","A1807G","G2659A","C6285T","T8593C","C9565T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14407T","C18171T","A20724G","A21717G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G23012A","G23593C","T24224C","C24748T","T26767C","T27205-","T27206-","T27207-","C28278-","T28279-","G28280-","C28308G","A28699G","C28887T","G29543T"],"M":["I82T"],"N":["S2-","D3Y","A12G","T205I"],"ORF6":["F2-"],"ORF9b":["H9D"],"S":["Q52R","A67V","H69-","V70-","Y144-","E484K","Q677H","F888L"],"nsp12":["L323F"],"nsp3":["T1189I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; N: S2-, D3Y, A12G, T205I; ORF6: F2-; ORF9b: H9D; S: Q52R, A67V, H69-, V70-, Y144-, E484K, Q677H, F888L; nsp12: L323F; nsp3: T1189I; nsp6: S106-, G107-, F108-","clade":"Eta","spike_mutations":"Q52R, A67V, H69-, V70-, Y144-, E484K, Q677H, F888L"}}},{"name":"B.1.537","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.537"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.537"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.682881832122803}},"branch_attrs":{"mutations":{"nuc":["G4354A","C6573T","C25528T"],"ORF3a":["L46F"],"nsp3":["S1285F"]},"labels":{"aa":"ORF3a: L46F; nsp3: S1285F"}}},{"name":"B.1.527","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.527"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.527"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.690547943115234}},"branch_attrs":{"mutations":{"nuc":["A1G","C6354T"],"nsp3":["S1212L"]},"labels":{"aa":"nsp3: S1212L"}}},{"name":"B.1.544","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.544"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.544"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.710533142089844}},"branch_attrs":{"mutations":{"nuc":["G13348T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"B.1.540","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.540"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.540"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.101134300231934}},"branch_attrs":{"mutations":{"nuc":["G28221T"],"ORF8":["E110*"]},"labels":{"aa":"ORF8: E110*"}}},{"name":"B.1.549","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.549"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.549"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.000479221343994}},"branch_attrs":{"mutations":{"nuc":["C1514T","G5542T","C10029T","A11451G","G17122T","G17320T","C18463T","G23611A"],"nsp13":["A296S","A362S"],"nsp14":["P142S"],"nsp2":["H237Y"],"nsp3":["Q941H"],"nsp4":["T492I"],"nsp6":["Q160R"]},"labels":{"aa":"nsp13: A296S, A362S; nsp14: P142S; nsp2: H237Y; nsp3: Q941H; nsp4: T492I; nsp6: Q160R"}}},{"name":"B.1.538","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.538"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.538"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.967286109924316}},"branch_attrs":{"mutations":{"nuc":["C313T","C5700A","C29870A"],"nsp3":["A994D"]},"labels":{"aa":"nsp3: A994D"}}},{"name":"B.1.560","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.560"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.560"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.9053778648376465}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}}},{"name":"B.1.618","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.618"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.618"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G105T","C853T","C1684T","A3830G","C4809T","T5263C","G14245A","A17066G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","G23012A","T25084C","C25844T","C26885T","G26909T","C27493T","G27852T","A27979T","G28325A","G28628T","G28922T","G28975T","G29372C"],"N":["G18S","A119S","A217S","M234I","E367Q"],"ORF3a":["T151I"],"ORF7a":["P34S"],"ORF7b":["E33*"],"ORF8":["Q29L"],"S":["Y145-","H146-","E484K"],"nsp12":["D269N"],"nsp13":["Y277C"],"nsp3":["S371G","S697F"]},"labels":{"aa":"N: G18S, A119S, A217S, M234I, E367Q; ORF3a: T151I; ORF7a: P34S; ORF7b: E33*; ORF8: Q29L; S: Y145-, H146-, E484K; nsp12: D269N; nsp13: Y277C; nsp3: S371G, S697F","spike_mutations":"Y145-, H146-, E484K"}}},{"name":"B.1.639","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.639"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.639"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.999648571014404}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22020C","C22995A","G23012A","C24138A","G24368T","A26161-","T27919C","A28271G","A28742G"],"N":["I157V"],"ORF3a":["N257-"],"ORF8":["I9T"],"S":["H69-","V70-","M153T","T478K","E484K","T859N","D936Y"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: I157V; ORF3a: N257-; ORF8: I9T; S: H69-, V70-, M153T, T478K, E484K, T859N, D936Y; nsp6: S106-, G107-, F108-","spike_mutations":"H69-, V70-, M153T, T478K, E484K, T859N, D936Y"}}},{"name":"B.1.8","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.8"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.388725757598877}},"branch_attrs":{"mutations":{"nuc":["A24862G"]}}},{"name":"B.1.78","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.78"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.78"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.461181163787842}},"branch_attrs":{"mutations":{"nuc":["G29422T"]}}},{"name":"B.1.91","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.91"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.91"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.197771072387695}},"branch_attrs":{"mutations":{"nuc":["G24077T"],"S":["D839Y"]},"labels":{"aa":"S: D839Y","spike_mutations":"D839Y"}}},{"name":"NODE_0000439","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.110"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.563884258270264}},"branch_attrs":{"mutations":{"nuc":["C8389T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.110","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.110"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.563884258270264}},"branch_attrs":{"mutations":{}}},{"name":"B.1.110.3","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.110.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.013157367706299}},"branch_attrs":{"mutations":{"nuc":["C601T","G27915A"],"ORF8":["G8R"]},"labels":{"aa":"ORF8: G8R"}}}]},{"name":"NODE_0000440","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.797828674316406}},"branch_attrs":{"mutations":{"nuc":["G3871T"],"nsp3":["K384N"]},"labels":{"aa":"nsp3: K384N"}},"children":[{"name":"B.1.378","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.378"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.378"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.797828674316406}},"branch_attrs":{"mutations":{"nuc":["A6-","G7-","G8-","T9-","T13-","A14-","C15-","C16-","T17-","T18-","C19-","C20-","C21-","A22-","G23-","G24-"]}}},{"name":"NODE_0000441","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.391294956207275}},"branch_attrs":{"mutations":{"nuc":["A696C","T3931C","C28977T"],"N":["S235F"],"nsp1":["D144A"]},"labels":{"aa":"N: S235F; nsp1: D144A"}},"children":[{"name":"B.1.139","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.139"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.139"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.391294956207275}},"branch_attrs":{"mutations":{}}},{"name":"B.1.565","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.565"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8670549392700195}},"branch_attrs":{"mutations":{"nuc":["C6285T","C19524T","C20429T"],"nsp15":["P270L"],"nsp3":["T1189I"]},"labels":{"aa":"nsp15: P270L; nsp3: T1189I"}}}]}]},{"name":"NODE_0000442","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.837924003601074}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","C23625T","A26161-"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"B.1.634","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.634"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G613A","C841T","A7142G","T8634C","A9614G","C9693T","A9754C","C11289-","G11291-","G11292-","G15451A","C16466T","C20823T","T21615G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A22036C","G23012A","C23854A","C26681T","T27645C","C27735T","A28271T","C28531T","C28606T","A28910T"],"N":["N213Y"],"ORF3a":["N257-"],"ORF9b":["T83I"],"S":["L18R","H69-","V70-","T95I","R158S","E484K","N764K"],"nsp12":["G671S"],"nsp13":["P77L"],"nsp3":["S1475G"],"nsp4":["I27T","T354A","A380V","R400S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: N213Y; ORF3a: N257-; ORF9b: T83I; S: L18R, H69-, V70-, T95I, R158S, E484K, N764K; nsp12: G671S; nsp13: P77L; nsp3: S1475G; nsp4: I27T, T354A, A380V, R400S; nsp6: S106-, G107-, F108-","spike_mutations":"L18R, H69-, V70-, T95I, R158S, E484K, N764K"}}},{"name":"NODE_0000443","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.440206527709961}},"branch_attrs":{"mutations":{"nuc":["C24642T"],"S":["T1027I"]},"labels":{"aa":"S: T1027I","spike_mutations":"T1027I"}},"children":[{"name":"B.1.636","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.636"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","C5907T","C5986T","A9085G","C11289-","G11291-","G11292-","C21614T","A22005C","G23867A","C25931T","-26161A","C27925T","A28295T","A28742G","G29734C"],"N":["N8Y","I157V"],"ORF3a":["S180F"],"ORF8":["T11I"],"ORF9b":["K4N"],"S":["L18F","N148T","G769R"],"nsp3":["T1063I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: N8Y, I157V; ORF3a: S180F; ORF8: T11I; ORF9b: K4N; S: L18F, N148T, G769R; nsp3: T1063I; nsp6: S106-, G107-, F108-","spike_mutations":"L18F, N148T, G769R"}}},{"name":"NODE_0000444","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A994G","G9756A","C9924T","A10982G","G11283-","T11284-","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C23604A","T23765G","C24442T","G26158-","T26159-","T26160-","C26222T"],"ORF3a":["V256-","N257-"],"S":["P681H","S735A"],"nsp4":["R401H","A457V"],"nsp6":["K4E","S104-"]},"labels":{"aa":"ORF3a: V256-, N257-; S: P681H, S735A; nsp4: R401H, A457V; nsp6: K4E, S104-","spike_mutations":"P681H, S735A"}},"children":[{"name":"B.1.627","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.627"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.627"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C1912T","C7869T","C9611T","T11285-","T20124A","T21752A","T22020C","C28923T","T29576-","T29577-","C29578-","G29579-","C29580-","T29581-","T29582-"],"N":["A217V"],"ORF10":["F7-","A8-","F9-"],"S":["W64R","M153T"],"nsp3":["S1717L"],"nsp4":["L353F"],"nsp6":["L105M"]},"labels":{"aa":"N: A217V; ORF10: F7-, A8-, F9-; S: W64R, M153T; nsp3: S1717L; nsp4: L353F; nsp6: L105M","spike_mutations":"W64R, M153T"}}},{"name":"B.1.631","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.631"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.631"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C829T","C4534T","C6120T","G7787A","A11282-","T21615G","C21846T","A22036C","C22916A","C25465T","C27769T","A28271-","A28330G","C28830T","G28907T","C28957T"],"N":["S186F","G212C"],"ORF3a":["P25S"],"ORF7b":["S5L"],"ORF9b":["D16G"],"S":["L18R","T95I","R158S","L452M"],"nsp3":["S1134L","A1690T"]},"labels":{"aa":"N: S186F, G212C; ORF3a: P25S; ORF7b: S5L; ORF9b: D16G; S: L18R, T95I, R158S, L452M; nsp3: S1134L, A1690T","spike_mutations":"L18R, T95I, R158S, L452M"}}}]}]}]},{"name":"NODE_0000445","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.317669153213501}},"branch_attrs":{"mutations":{"nuc":["C2416T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.279","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.279"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.279"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.854539155960083}},"branch_attrs":{"mutations":{"nuc":["C1913T","G2528A","C12525T","C16806T","G20014T","A25718G"],"ORF3a":["Y109C"],"nsp15":["D132Y"],"nsp2":["R370C","E575K"],"nsp8":["T145I"]},"labels":{"aa":"ORF3a: Y109C; nsp15: D132Y; nsp2: R370C, E575K; nsp8: T145I"}}},{"name":"NODE_0000446","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.214023113250732}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.389","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.389"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.389"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G8371T","C9430T","A15477T","C18395T","A20622T","G20623T","A20624T","C23730T","A26319G","G29044A"],"S":["T723I"],"nsp14":["A119V"],"nsp15":["K334N","D335F"],"nsp3":["Q1884H"]},"labels":{"aa":"S: T723I; nsp14: A119V; nsp15: K334N, D335F; nsp3: Q1884H","spike_mutations":"T723I"}}},{"name":"B.1.480","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.480"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.480"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.699550151824951}},"branch_attrs":{"mutations":{"nuc":["C875T","A10904G","G25249T"],"S":["M1229I"],"nsp2":["L24F"],"nsp5":["S284G"]},"labels":{"aa":"S: M1229I; nsp2: L24F; nsp5: S284G","spike_mutations":"M1229I"}}}]},{"name":"NODE_0000447","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.958614826202393}},"branch_attrs":{"mutations":{"nuc":["C14322T","C23604A","G23948T","T26038C"],"ORF3a":["S216P"],"S":["P681H","D796Y"]},"labels":{"aa":"ORF3a: S216P; S: P681H, D796Y","spike_mutations":"P681H, D796Y"}},"children":[{"name":"B.1.474","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.474"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.474"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.585630416870117}},"branch_attrs":{"mutations":{"nuc":["C539T","C5884T","C7834T","G8618A","C15579T","G16912T","C25207T","C26600T","C27970A","C28887T"],"N":["T205I"],"ORF8":["T26N"],"nsp1":["L92F"],"nsp13":["V226L"],"nsp4":["A22T"]},"labels":{"aa":"N: T205I; ORF8: T26N; nsp1: L92F; nsp13: V226L; nsp4: A22T"}}},{"name":"B.1.629","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.629"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.629"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C815T","C1191T","C3040T","A4229C","T5095C","C5178T","G11128A","C12459T","G21987A","A22107G","T22917G","C22995A","G25266T","C25433T","T26498C","T26767G","A28482G","C28833T","C28926T"],"M":["I82S"],"N":["Q70R","S187L","A218V"],"ORF3a":["T14I"],"ORF9b":["K67E"],"S":["G142D","K182R","L452R","T478K","C1235F"],"nsp2":["R4C","P129L"],"nsp3":["T504P","T820I"],"nsp6":["M52I"],"nsp8":["T123I"]},"labels":{"aa":"M: I82S; N: Q70R, S187L, A218V; ORF3a: T14I; ORF9b: K67E; S: G142D, K182R, L452R, T478K, C1235F; nsp2: R4C, P129L; nsp3: T504P, T820I; nsp6: M52I; nsp8: T123I","spike_mutations":"G142D, K182R, L452R, T478K, C1235F"}}}]}]},{"name":"NODE_0000448","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.357755661010742}},"branch_attrs":{"mutations":{"nuc":["C15324T"]}},"children":[{"name":"B.1.146","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.146"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.146"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C10833T","G28747T","G28917T","G29543T"],"N":["G215V"],"nsp5":["A260V"]},"labels":{"aa":"N: G215V; nsp5: A260V"}}},{"name":"B.1.147","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.147"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.147"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.98856782913208}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"B.1.149","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.149"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.149"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.820705890655518}},"branch_attrs":{"mutations":{"nuc":["G16846T"],"nsp13":["D204Y"]},"labels":{"aa":"nsp13: D204Y"}}},{"name":"B.1.210","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.210"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.210"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.527243614196777}},"branch_attrs":{"mutations":{"nuc":["A1C","C3634T"]}}},{"name":"B.1.212","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.212"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.212"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.8698015213012695}},"branch_attrs":{"mutations":{"nuc":["C16428T"]}}},{"name":"B.1.221","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.221"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.221"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.022773027420044}},"branch_attrs":{"mutations":{"nuc":["C3602T","C6941T","C21855T","A25505G","G25906C","G25996T","C28651T","C28869T"],"N":["P199L"],"ORF3a":["Q38R","G172R","V202L"],"S":["S98F"],"nsp3":["H295Y"]},"labels":{"aa":"N: P199L; ORF3a: Q38R, G172R, V202L; S: S98F; nsp3: H295Y","spike_mutations":"S98F"}}},{"name":"B.1.219","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.219"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.219"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.373754501342773}},"branch_attrs":{"mutations":{"nuc":["T13A","C16193T","A22404T"],"S":["E281V"],"nsp12":["P918L"]},"labels":{"aa":"S: E281V; nsp12: P918L","spike_mutations":"E281V"}}},{"name":"B.1.620","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.620"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.620"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A22T","C1473T","G6236A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G17110T","T20049C","C21638T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21939C","T21992-","A21993-","T21994-","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","C22295T","C22498T","G22992A","G23012A","A23416T","C23604A","C24642T","G24914C","A28271T","T28297C","C28932T"],"N":["A220V"],"ORF9b":["I5T"],"S":["P26S","H69-","V70-","V126A","Y144-","L241-","L242-","A243-","H245Y","S477N","E484K","P681H","T1027I","D1118H"],"nsp13":["A292S"],"nsp2":["T223I"],"nsp3":["V1173I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: A220V; ORF9b: I5T; S: P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H; nsp13: A292S; nsp2: T223I; nsp3: V1173I; nsp6: S106-, G107-, F108-","spike_mutations":"P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H"}}}]},{"name":"NODE_0000449","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9689385890960693}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.530","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.530"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.530"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G61T","A3291G","C11050T","G16935T","A19339G","C23604A","C26549T","T29471C"],"S":["P681H"],"nsp13":["M233I"],"nsp14":["S434G"],"nsp3":["Q191R"]},"labels":{"aa":"S: P681H; nsp13: M233I; nsp14: S434G; nsp3: Q191R","spike_mutations":"P681H"}}},{"name":"NODE_0000450","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.214"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-7.439484119415283}},"branch_attrs":{"mutations":{"nuc":["A4457G","C5907T","C12312T","C15324T"],"nsp3":["I580V","T1063I"],"nsp8":["A74V"]},"labels":{"aa":"nsp3: I580V, T1063I; nsp8: A74V"}},"children":[{"name":"B.1.214.1","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.214.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.222192764282227}},"branch_attrs":{"mutations":{"nuc":["A481G","C5144T","C17304G","C17999T"],"nsp13":["T588I"]},"labels":{"aa":"nsp13: T588I"}}},{"name":"B.1.214","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.214"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.219902992248535}},"branch_attrs":{"mutations":{"nuc":["T28887C"],"N":["I205T"]},"labels":{"aa":"N: I205T"}}},{"name":"NODE_0000451","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.214"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C4891T","A15187G","C23709T","T27576C","G28280C","A28281T","T28282A","C28846T"],"N":["D3L"],"S":["T716I"],"nsp12":["R583G"]},"labels":{"aa":"N: D3L; S: T716I; nsp12: R583G","spike_mutations":"T716I"}},"children":[{"name":"B.1.214.2","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.214.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:29-276"},"designation_date":{"value":"2021-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9553585052490234}},"branch_attrs":{"mutations":{"nuc":["C22802A","T22912G","A25448-","A25449-","A25450-","T25451-","C25452-","A25453-","A25454-","G25455-","G25456-","A25457-","T25458-","G25459-","C25460-","T25461-","A25462-","C25463-","T25464-","C25465-","C25466-","T25467-","T25468-","C25469-","A25470-","G25471-","A25472-","T25473-","T25474-","T25475-"],"ORF3a":["E19-","I20-","K21-","D22-","A23-","T24-","P25-","S26-","D27-","F28-"],"S":["Q414K","N450K"]},"labels":{"aa":"ORF3a: E19-, I20-, K21-, D22-, A23-, T24-, P25-, S26-, D27-, F28-; S: Q414K, N450K","spike_mutations":"Q414K, N450K"}}},{"name":"B.1.214.3","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.214.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C673T","A11282-","G11283-","T11284-","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291T","A11430G","C21846T"],"S":["T95I"],"nsp6":["S104-","L105-","S106-","G107C","Y153C"]},"labels":{"aa":"S: T95I; nsp6: S104-, L105-, S106-, G107C, Y153C","spike_mutations":"T95I"}}}]}]},{"name":"NODE_0000452","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.162606716156006}},"branch_attrs":{"mutations":{"nuc":["T26767C"],"M":["I82T"]},"labels":{"aa":"M: I82T"}},"children":[{"name":"NODE_0000453","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.605557441711426}},"branch_attrs":{"mutations":{"nuc":["C23604A","C24138A","A28271-"],"S":["P681H","T859N"]},"labels":{"aa":"S: P681H, T859N","spike_mutations":"P681H, T859N"}},"children":[{"name":"B.1.415.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.415.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.415.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1150T","T7185C","C8251T","A11023T","A11217G","C13458T","G15732T","T16348C","A16619G","A18410G","T19143C","A20268G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C22286-","T22287-","T22288-","G22299C","G22599A","G23012A","A23064C","C24507T","G26840T","G28178A","G28302A","C28932T"],"N":["R10Q","A220V"],"ORF9b":["E7K"],"S":["H69-","V70-","L241-","R246T","R346K","E484K","N501T","S982L"],"nsp11":["S6L"],"nsp12":["S6L"],"nsp13":["S38P","E128G"],"nsp14":["Y124C"],"nsp3":["I1489T"],"nsp6":["N82S"]},"labels":{"aa":"N: R10Q, A220V; ORF9b: E7K; S: H69-, V70-, L241-, R246T, R346K, E484K, N501T, S982L; nsp11: S6L; nsp12: S6L; nsp13: S38P, E128G; nsp14: Y124C; nsp3: I1489T; nsp6: N82S","spike_mutations":"H69-, V70-, L241-, R246T, R346K, E484K, N501T, S982L"}}},{"name":"B.1.640.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"B.1.640.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.640.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C601T","C1191T","A1620G","C2416T","C2455T","G6622T","C9711T","G9756A","C10029T","T11418C","C11956T","C16575T","C16869T","C20283T","C21588T","G21848C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","G22132T","T22191C","A22600C","A22743G","T22907A","T23030C","T23031G","A23063T","G24368C","C25487T","G25563T","A26492T","C27513T","C27807T","C27972T","T28297C","G28337T","T29377C","G29405C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","G29779T"],"N":["D22Y","E378Q"],"ORF3a":["T32I","Q57H"],"ORF8":["Q27*"],"ORF9b":["I5T","Q18H"],"S":["P9L","E96Q","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","R190S","I210T","R346S","N394S","Y449N","F490R","N501Y","D936H"],"nsp2":["P129L","E272G"],"nsp3":["L1301F"],"nsp4":["S386F","R401H","T492I"],"nsp6":["V149A"]},"labels":{"aa":"N: D22Y, E378Q; ORF3a: T32I, Q57H; ORF8: Q27*; ORF9b: I5T, Q18H; S: P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, R190S, I210T, R346S, N394S, Y449N, F490R, N501Y, D936H; nsp2: P129L, E272G; nsp3: L1301F; nsp4: S386F, R401H, T492I; nsp6: V149A","spike_mutations":"P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, R190S, I210T, R346S, N394S, Y449N, F490R, N501Y, D936H"}}}]},{"name":"NODE_0000454","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.619"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2407A","G5008T","C6633T","G8084A","C8311T","C9319T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11521T","C12473T","C14403T","C15324T","G19962A","C21637T","T22191C","T22882G","G23012A","T24194C","G24368A","C24378T","C24642T","G26211T","C26606T","G27459T","C28311T","G28875T"],"N":["P13L","S201I"],"ORF7a":["E22D"],"ORF9b":["P10S"],"S":["I210T","N440K","E484K","D936N","S939F","T1027I"],"nsp3":["A1305V","E1789K"],"nsp6":["S106-","G107-","F108-","M183I"]},"labels":{"aa":"N: P13L, S201I; ORF7a: E22D; ORF9b: P10S; S: I210T, N440K, E484K, D936N, S939F, T1027I; nsp3: A1305V, E1789K; nsp6: S106-, G107-, F108-, M183I","spike_mutations":"I210T, N440K, E484K, D936N, S939F, T1027I"}},"children":[{"name":"B.1.619","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.619"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"B.1.619.1","node_attrs":{"div":38,"Nextclade_pango":{"value":"B.1.619.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C19T","T5701C","A12051G","A21213G","T22738C","A28271-","C28441T","T28600C","C28957T"],"ORF9b":["S53L"],"nsp7":["K70R"]},"labels":{"aa":"ORF9b: S53L; nsp7: K70R"}}}]}]}]},{"name":"NODE_0000455","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.1044530868530273}},"branch_attrs":{"mutations":{"nuc":["T445C","C6286T","G21255C","C22227T","C26801G","C28932T","G29645T"],"N":["A220V"],"ORF10":["V30L"],"S":["A222V"]},"labels":{"aa":"N: A220V; ORF10: V30L; S: A222V","clade":"20E","spike_mutations":"A222V"}},"children":[{"name":"B.1.177","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.177"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.1044530868530273}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.15","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.15"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.15"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.812208652496338}},"branch_attrs":{"mutations":{"nuc":["C5170T","C10078T","G11132T","G11417T","G22051T","G29179T"],"nsp6":["A54S","V149F"]},"labels":{"aa":"nsp6: A54S, V149F"}}},{"name":"B.1.177.18","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.18"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.1767425537109375}},"branch_attrs":{"mutations":{"nuc":["A10323G","G23311C","G25440T","C27752T"],"ORF3a":["K16N"],"ORF7a":["T120I"],"S":["E583D"],"nsp5":["K90R"]},"labels":{"aa":"ORF3a: K16N; ORF7a: T120I; S: E583D; nsp5: K90R","spike_mutations":"E583D"}}},{"name":"B.1.177.16","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.16"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.051562786102295}},"branch_attrs":{"mutations":{"nuc":["C28310A"],"N":["P13T"],"ORF9b":["H9Q"]},"labels":{"aa":"N: P13T; ORF9b: H9Q"}}},{"name":"B.1.177.32","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.32"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.204548358917236}},"branch_attrs":{"mutations":{"nuc":["C5700T","C11152T"],"nsp3":["A994V"]},"labels":{"aa":"nsp3: A994V"}}},{"name":"B.1.177.73","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.73"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.73"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.086843013763428}},"branch_attrs":{"mutations":{"nuc":["G1820A","A2473G","T7543C","C13671T","A24774T","C26060A"],"ORF3a":["T223N"],"S":["Q1071L"],"nsp2":["G339S"]},"labels":{"aa":"ORF3a: T223N; S: Q1071L; nsp2: G339S","spike_mutations":"Q1071L"}}},{"name":"B.1.177.75","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.75"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.75"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.156762599945068}},"branch_attrs":{"mutations":{"nuc":["A1C","T8284C"]}}},{"name":"NODE_0000456","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.143012046813965}},"branch_attrs":{"mutations":{"nuc":["C222T","T20661C","C29386T"]}},"children":[{"name":"B.1.177.44","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.44"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.44"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.074658393859863}},"branch_attrs":{"mutations":{"nuc":["G21468T"],"nsp16":["M270I"]},"labels":{"aa":"nsp16: M270I"}}},{"name":"NODE_0000457","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.473905563354492}},"branch_attrs":{"mutations":{"nuc":["C29366T"],"N":["P365S"]},"labels":{"aa":"N: P365S"}},"children":[{"name":"B.1.177.12","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.12"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.12"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.39573073387146}},"branch_attrs":{"mutations":{"nuc":["T24814C","G25757T"],"ORF3a":["R122I"]},"labels":{"aa":"ORF3a: R122I"}}},{"name":"B.1.177.35","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.35"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.8779044151306152}},"branch_attrs":{"mutations":{"nuc":["T26966C"]}}}]}]},{"name":"NODE_0000458","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.924924850463867}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}},"children":[{"name":"B.1.177.10","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.10"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.106119155883789}},"branch_attrs":{"mutations":{"nuc":["G28321A"],"ORF9b":["R13H"]},"labels":{"aa":"ORF9b: R13H"}}},{"name":"B.1.177.46","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.46"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.46"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.15555477142334}},"branch_attrs":{"mutations":{"nuc":["C9693T","C18508T","G29179T"],"nsp14":["L157F"],"nsp4":["A380V"]},"labels":{"aa":"nsp14: L157F; nsp4: A380V"}}},{"name":"NODE_0000459","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4437451362609863}},"branch_attrs":{"mutations":{"nuc":["C1513T","C22377T"],"S":["P272L"]},"labels":{"aa":"S: P272L","spike_mutations":"P272L"}},"children":[{"name":"B.1.177.82","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.82"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.82"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.837984561920166}},"branch_attrs":{"mutations":{"nuc":["G28378T","G29757T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.177.83","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.83"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.83"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.299724578857422}},"branch_attrs":{"mutations":{"nuc":["C2062T"]}}},{"name":"B.1.177.87","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.87"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.87"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.9360873699188232}},"branch_attrs":{"mutations":{"nuc":["C28706T","C29095T"],"N":["H145Y"]},"labels":{"aa":"N: H145Y"}}}]}]},{"name":"NODE_0000460","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.161717653274536}},"branch_attrs":{"mutations":{"nuc":["C27944T"]}},"children":[{"name":"B.1.177.4","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.4"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.478666067123413}},"branch_attrs":{"mutations":{"nuc":["C66T","A1987G","G10870T","C25614T"]}}},{"name":"B.1.177.52","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.52"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.52"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.295443534851074}},"branch_attrs":{"mutations":{"nuc":["A1T","G5023T","C25047G"],"S":["P1162R"],"nsp3":["M768I"]},"labels":{"aa":"S: P1162R; nsp3: M768I","spike_mutations":"P1162R"}}},{"name":"B.1.177.81","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.81"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.81"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.3990318775177}},"branch_attrs":{"mutations":{"nuc":["C12119T","A21222T","C25889T"],"ORF3a":["S166L"],"nsp8":["P10S"]},"labels":{"aa":"ORF3a: S166L; nsp8: P10S"}}},{"name":"NODE_0000461","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.53"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.278009414672852}},"branch_attrs":{"mutations":{"nuc":["C2973T","G9805T"],"nsp3":["A85V"]},"labels":{"aa":"nsp3: A85V"}},"children":[{"name":"B.1.177.53","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.53"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.278009414672852}},"branch_attrs":{"mutations":{}}},{"name":"W.1","node_attrs":{"div":18,"Nextclade_pango":{"value":"W.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53.1"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-5.000479221343994}},"branch_attrs":{"mutations":{"nuc":["C17463T","C17676T","T24799C","G25785T"],"ORF3a":["W131C"]},"labels":{"aa":"ORF3a: W131C"}}}]},{"name":"NODE_0000462","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.13129186630249}},"branch_attrs":{"mutations":{"nuc":["G204T"]}},"children":[{"name":"B.1.177.21","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.21"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.21"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.0787036418914795}},"branch_attrs":{"mutations":{"nuc":["T16242A"]}}},{"name":"B.1.177.77","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.77"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.77"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.0452117919921875}},"branch_attrs":{"mutations":{"nuc":["T3592C","C13517T"],"nsp12":["T26I"]},"labels":{"aa":"nsp12: T26I"}}},{"name":"NODE_0000463","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.644141674041748}},"branch_attrs":{"mutations":{"nuc":["C9745T"]}},"children":[{"name":"B.1.177.54","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.177.54"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.54"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.974447011947632}},"branch_attrs":{"mutations":{"nuc":["C23644T","T25878C","G25879A","A25881T"],"ORF3a":["V163I"]},"labels":{"aa":"ORF3a: V163I"}}},{"name":"NODE_0000464","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.35325288772583}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"nsp3":["A1736V"]},"labels":{"aa":"nsp3: A1736V"}},"children":[{"name":"B.1.177.57","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.57"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.57"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.707308769226074}},"branch_attrs":{"mutations":{"nuc":["C6807T"],"nsp3":["T1363I"]},"labels":{"aa":"nsp3: T1363I"}}},{"name":"B.1.177.56","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.56"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.56"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.35325288772583}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000465","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-2.566998243331909}},"branch_attrs":{"mutations":{"nuc":["C21614T"],"S":["L18F"]},"labels":{"aa":"S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.177.5","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.5"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.151096820831299}},"branch_attrs":{"mutations":{"nuc":["T24769C","C25460T"],"ORF3a":["A23V"]},"labels":{"aa":"ORF3a: A23V"}}},{"name":"B.1.177.60","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.60"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.60"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.3496036529541016}},"branch_attrs":{"mutations":{"nuc":["A1G","G25621T"],"ORF3a":["V77F"]},"labels":{"aa":"ORF3a: V77F"}}},{"name":"B.1.177.62","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.177.62"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.62"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.268250465393066}},"branch_attrs":{"mutations":{"nuc":["C7195T","C21714T","G24368T","G25855T"],"ORF3a":["D155Y"],"S":["T51I","D936Y"]},"labels":{"aa":"ORF3a: D155Y; S: T51I, D936Y","spike_mutations":"T51I, D936Y"}}},{"name":"B.1.177.7","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.7"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.7"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4441723823547363}},"branch_attrs":{"mutations":{"nuc":["C15480T"]}}},{"name":"B.1.177.8","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.8"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.112913131713867}},"branch_attrs":{"mutations":{"nuc":["G8179T"]}}},{"name":"B.1.177.86","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.86"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.86"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4548094272613525}},"branch_attrs":{"mutations":{"nuc":["C6040T","G26801T","G27870T"],"ORF7b":["E39*"]},"labels":{"aa":"ORF7b: E39*"}}}]}]}]}]},{"name":"NODE_0000466","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.2661590576171875}},"branch_attrs":{"mutations":{"nuc":["A20268G"]}},"children":[{"name":"B.1.189","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.189"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.189"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.054994106292725}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.192","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.192"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.192"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.370109558105469}},"branch_attrs":{"mutations":{"nuc":["C11833T"]}}},{"name":"B.1.237","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.237"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.237"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.828962326049805}},"branch_attrs":{"mutations":{"nuc":["G2164C"],"nsp2":["E453D"]},"labels":{"aa":"nsp2: E453D"}}},{"name":"B.1.381","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.381"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.381"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.034300327301025}},"branch_attrs":{"mutations":{"nuc":["C355T","C4093T"]}}},{"name":"B.1.420","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.420"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.420"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.054104328155518}},"branch_attrs":{"mutations":{"nuc":["T23443C"]}}},{"name":"B.1.417","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.417"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.417"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.156829357147217}},"branch_attrs":{"mutations":{"nuc":["T5422C","C7051T","G7743T","C12880T"],"nsp3":["S1675I"]},"labels":{"aa":"nsp3: S1675I"}}},{"name":"B.1.600","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.600"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.600"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.995579719543457}},"branch_attrs":{"mutations":{"nuc":["A5G","A6G","G7A","C5784T","C27982T"],"ORF8":["P30L"],"nsp3":["T1022I"]},"labels":{"aa":"ORF8: P30L; nsp3: T1022I"}}},{"name":"B.1.609","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.609"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.609"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.865769147872925}},"branch_attrs":{"mutations":{"nuc":["C4582T"]}}},{"name":"NODE_0000467","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.416"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.642777442932129}},"branch_attrs":{"mutations":{"nuc":["A1C","C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}},"children":[{"name":"B.1.416","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.416"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.278482437133789}},"branch_attrs":{"mutations":{"nuc":["C1625T"],"nsp2":["L274F"]},"labels":{"aa":"nsp2: L274F"}}},{"name":"B.1.416.1","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.416.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.303077220916748}},"branch_attrs":{"mutations":{"nuc":["C25731T"]}}}]},{"name":"NODE_0000468","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{"nuc":["A1G","T7767C","C8047T","C17104T","C22879A","G29734C"],"S":["N439K"],"nsp13":["H290Y"],"nsp3":["I1683T"]},"labels":{"aa":"S: N439K; nsp13: H290Y; nsp3: I1683T","spike_mutations":"N439K"}},"children":[{"name":"B.1.258","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.258"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{}}},{"name":"B.1.258.3","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.258.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.964566469192505}},"branch_attrs":{"mutations":{"nuc":["G1464A","A10978T","G18803T","T20799C"],"nsp14":["S255I"],"nsp2":["G220D"]},"labels":{"aa":"nsp14: S255I; nsp2: G220D"}}},{"name":"NODE_0000469","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.993483066558838}},"branch_attrs":{"mutations":{"nuc":["C27800A"]}},"children":[{"name":"B.1.258.14","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.258.14"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.14"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.224915981292725}},"branch_attrs":{"mutations":{"nuc":["G1A","C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}}},{"name":"NODE_0000470","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.193143606185913}},"branch_attrs":{"mutations":{"nuc":["G12988T","G15598A","G18028T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T24910C","T26972C"],"S":["H69-","V70-"],"nsp12":["V720I"],"nsp13":["A598S"],"nsp9":["M101I"]},"labels":{"aa":"S: H69-, V70-; nsp12: V720I; nsp13: A598S; nsp9: M101I","spike_mutations":"H69-, V70-"}},"children":[{"name":"B.1.258.11","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.258.11"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.11"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.367208480834961}},"branch_attrs":{"mutations":{"nuc":["C12455T","C20451T"],"nsp8":["L122F"]},"labels":{"aa":"nsp8: L122F"}}},{"name":"B.1.258.17","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.258.17"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.17"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.1944985389709473}},"branch_attrs":{"mutations":{"nuc":["C829T","C14697T","C16394T","C18176T","G19398T","C22127T","G23876A","G25947T"],"ORF3a":["Q185H"],"S":["L189F","V772I"],"nsp13":["P53L"],"nsp14":["P46L","E453D"]},"labels":{"aa":"ORF3a: Q185H; S: L189F, V772I; nsp13: P53L; nsp14: P46L, E453D","spike_mutations":"L189F, V772I"}}}]}]}]},{"name":"NODE_0000471","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.039437770843506}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.232","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.232"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.232"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8121721744537354}},"branch_attrs":{"mutations":{"nuc":["G27987T"],"ORF8":["V32L"]},"labels":{"aa":"ORF8: V32L"}}},{"name":"B.1.234","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.234"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.234"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.2358059883117676}},"branch_attrs":{"mutations":{"nuc":["G2258A","A6441G","C8140T","A9204G"],"nsp2":["V485I"],"nsp3":["K1241R"],"nsp4":["D217G"]},"labels":{"aa":"nsp2: V485I; nsp3: K1241R; nsp4: D217G"}}},{"name":"B.1.239","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.239"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.239"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.158753395080566}},"branch_attrs":{"mutations":{"nuc":["G16741A"],"nsp13":["V169I"]},"labels":{"aa":"nsp13: V169I"}}},{"name":"B.1.236","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.236"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.236"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.485028266906738}},"branch_attrs":{"mutations":{"nuc":["G11842A","A12759G","G18292T"],"nsp14":["A85S"],"nsp9":["D25G"]},"labels":{"aa":"nsp14: A85S; nsp9: D25G"}}},{"name":"B.1.243","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.243"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.243"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.000774383544922}},"branch_attrs":{"mutations":{"nuc":["T24076C"]}}},{"name":"B.1.241","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.241"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.241"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9246673583984375}},"branch_attrs":{"mutations":{"nuc":["C11575T"]}}},{"name":"B.1.397","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.397"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.397"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.800171375274658}},"branch_attrs":{"mutations":{"nuc":["G1135T"],"nsp2":["K110N"]},"labels":{"aa":"nsp2: K110N"}}},{"name":"B.1.398","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.398"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.398"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.523492813110352}},"branch_attrs":{"mutations":{"nuc":["G4136A","C11224T","C12295A","C21846T"],"S":["T95I"],"nsp3":["V473I"]},"labels":{"aa":"S: T95I; nsp3: V473I","spike_mutations":"T95I"}}},{"name":"B.1.396","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.396"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.396"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1198410987854}},"branch_attrs":{"mutations":{"nuc":["C1191T","C9521A","C24904T","G29422T","A29567G"],"ORF10":["I4V"],"nsp2":["P129L"],"nsp4":["L323I"]},"labels":{"aa":"ORF10: I4V; nsp2: P129L; nsp4: L323I"}}},{"name":"B.1.399","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.399"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.399"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.258176326751709}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}}},{"name":"B.1.400","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.400"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.400"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.643618583679199}},"branch_attrs":{"mutations":{"nuc":["G19969A"],"nsp15":["A117T"]},"labels":{"aa":"nsp15: A117T"}}},{"name":"B.1.402","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.402"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.402"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.080169677734375}},"branch_attrs":{"mutations":{"nuc":["C4633T","T14643C","C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"B.1.409","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.409"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.409"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1198410987854}},"branch_attrs":{"mutations":{"nuc":["G3527A","G5015A","A5877G","G8017T","C11008T","C20283T","C25714T","G25855T","C27434T","C27998T"],"ORF3a":["L108F","D155Y"],"ORF7a":["T14I"],"nsp3":["D270N","V766M","N1053S"]},"labels":{"aa":"ORF3a: L108F, D155Y; ORF7a: T14I; nsp3: D270N, V766M, N1053S"}}},{"name":"B.1.551","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.551"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.551"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.054353713989258}},"branch_attrs":{"mutations":{"nuc":["C3738T","C23604G"],"S":["P681R"],"nsp3":["P340L"]},"labels":{"aa":"S: P681R; nsp3: P340L","spike_mutations":"P681R"}}},{"name":"B.1.558","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.558"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.558"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.004430770874023}},"branch_attrs":{"mutations":{"nuc":["C1288T"]}}},{"name":"NODE_0000472","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.240"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.6813478469848633}},"branch_attrs":{"mutations":{"nuc":["C18486T","T22162C"]}},"children":[{"name":"B.1.240","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.240"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.6813478469848633}},"branch_attrs":{"mutations":{}}},{"name":"B.1.240.1","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.240.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-8.332109451293945}},"branch_attrs":{"mutations":{"nuc":["G10610T","G10870T","G11335T","C14262T","G29494A"],"nsp5":["V186F"]},"labels":{"aa":"nsp5: V186F"}}}]},{"name":"NODE_0000473","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.489289283752441}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"B.1.404","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.404"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.404"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["G5572T","G7042T","A12644G","T16743C","G19086T","G22992A"],"S":["S477N"],"nsp14":["K349N"],"nsp3":["M951I","M1441I"],"nsp8":["I185V"]},"labels":{"aa":"S: S477N; nsp14: K349N; nsp3: M951I, M1441I; nsp8: I185V","spike_mutations":"S477N"}}},{"name":"B.1.561","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.561"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.561"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.697448492050171}},"branch_attrs":{"mutations":{"nuc":["G2516T","A5999G","C18693T","G21974T","T25577C","G28975T"],"N":["M234I"],"ORF3a":["I62T"],"S":["D138Y"],"nsp2":["V571L"],"nsp3":["I1094V"]},"labels":{"aa":"N: M234I; ORF3a: I62T; S: D138Y; nsp2: V571L; nsp3: I1094V","spike_mutations":"D138Y"}}}]}]}]},{"name":"NODE_0000474","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7314677238464355}},"branch_attrs":{"mutations":{"nuc":["C18877T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.111","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.111"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.111"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.20757532119751}},"branch_attrs":{"mutations":{"nuc":["C10507T"]}}},{"name":"B.1.170","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.170"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.170"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7314677238464355}},"branch_attrs":{"mutations":{}}},{"name":"B.1.436","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.436"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.436"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.123282432556152}},"branch_attrs":{"mutations":{"nuc":["C28890T","T29710A"],"N":["S206F"]},"labels":{"aa":"N: S206F"}}},{"name":"B.1.438","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.438"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.438"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.653946399688721}},"branch_attrs":{"mutations":{"nuc":["A1154G","G29474T"],"N":["D401Y"],"nsp2":["M117V"]},"labels":{"aa":"N: D401Y; nsp2: M117V"}}},{"name":"B.1.441","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.441"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.441"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.796097755432129}},"branch_attrs":{"mutations":{"nuc":["T8296C","G28690T"],"N":["L139F"]},"labels":{"aa":"N: L139F"}}},{"name":"NODE_0000475","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.9"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.251059532165527}},"branch_attrs":{"mutations":{"nuc":["C7765T","C17690T"],"nsp13":["S485L"]},"labels":{"aa":"nsp13: S485L"}},"children":[{"name":"B.1.9","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.655979633331299}},"branch_attrs":{"mutations":{"nuc":["C2113T"]}}},{"name":"B.1.9.5","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9.5"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.251059532165527}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000476","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.02042293548584}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}},"children":[{"name":"B.1.459","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.459"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.459"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.765696048736572}},"branch_attrs":{"mutations":{"nuc":["C5184T"],"nsp3":["P822L"]},"labels":{"aa":"nsp3: P822L"}}},{"name":"B.1.462","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.462"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.462"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.719885349273682}},"branch_attrs":{"mutations":{"nuc":["C3811T"]}}},{"name":"B.1.465","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.465"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.465"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.7676591873168945}},"branch_attrs":{"mutations":{"nuc":["G24197T"],"S":["A879S"]},"labels":{"aa":"S: A879S","spike_mutations":"A879S"}}},{"name":"B.1.469","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.469"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.469"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.699280738830566}},"branch_attrs":{"mutations":{"nuc":["A12075G","A21137G","C28866T"],"N":["T198I"],"nsp16":["K160R"],"nsp7":["N78S"]},"labels":{"aa":"N: T198I; nsp16: K160R; nsp7: N78S"}}},{"name":"B.1.471","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.471"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.471"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.839853286743164}},"branch_attrs":{"mutations":{"nuc":["C16915T","T24202C"]}}},{"name":"B.1.470","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.470"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.470"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.865800857543945}},"branch_attrs":{"mutations":{"nuc":["C14120T"],"nsp12":["P227L"]},"labels":{"aa":"nsp12: P227L"}}},{"name":"NODE_0000477","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.160"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-2.896782875061035}},"branch_attrs":{"mutations":{"nuc":["C4543T","G5629T","G9526T","C11497T","G13993T","G15766T","A16889G","G17019T","G22992A","C25710T","T26876C","G28975C","G29399A"],"N":["M234I","A376T"],"S":["S477N"],"nsp12":["A185S","V776L"],"nsp13":["K218R","E261D"],"nsp4":["M324I"]},"labels":{"aa":"N: M234I, A376T; S: S477N; nsp12: A185S, V776L; nsp13: K218R, E261D; nsp4: M324I","spike_mutations":"S477N"}},"children":[{"name":"B.1.160","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.160"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-2.896782875061035}},"branch_attrs":{"mutations":{}}},{"name":"B.1.160.16","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.160.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160.16"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.024463176727295}},"branch_attrs":{"mutations":{"nuc":["C27434T","C27964T","G29557T"],"ORF7a":["T14I"],"ORF8":["S24L"]},"labels":{"aa":"ORF7a: T14I; ORF8: S24L"}}}]},{"name":"NODE_0000478","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.627126216888428}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36.19","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.19"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.19"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.075583457946777}},"branch_attrs":{"mutations":{"nuc":["A1C","G28086T","C29614T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"B.1.456","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.456"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.456"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.627126216888428}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000479","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.466"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.84882926940918}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.466","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.466"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.84882926940918}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000480","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.466"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.935308456420898}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.466.1","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.466.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["A3423G","C6318A","C15026T","A19960G","G25526T","C25553T","C26111T","A29019G","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K249R"],"ORF3a":["W45L","A54V","P240L"],"nsp12":["A529V"],"nsp15":["T114A"],"nsp3":["K235R","P1200Q"]},"labels":{"aa":"N: K249R; ORF3a: W45L, A54V, P240L; nsp12: A529V; nsp15: T114A; nsp3: K235R, P1200Q"}}},{"name":"NODE_0000481","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.466.2"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.372191429138184}},"branch_attrs":{"mutations":{"nuc":["C3768T","C5184T"],"nsp3":["T350I","P822L"]},"labels":{"aa":"nsp3: T350I, P822L"}},"children":[{"name":"B.1.466.2","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.466.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.372191429138184}},"branch_attrs":{"mutations":{"nuc":["A29897T","A29898G","A29899G","A29902G"]}}},{"name":"NODE_0000482","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.466.2"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7382194995880127}},"branch_attrs":{"mutations":{"nuc":["C683T","C3096T","C11195T","C12880T","C17012T","T22219C","C23604G","C29718T","C29743T"],"S":["P681R"],"nsp13":["S259L"],"nsp3":["S126L"],"nsp6":["L75F"]},"labels":{"aa":"S: P681R; nsp13: S259L; nsp3: S126L; nsp6: L75F","spike_mutations":"P681R"}},"children":[{"name":"AU.2","node_attrs":{"div":24,"Nextclade_pango":{"value":"AU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.538213729858398}},"branch_attrs":{"mutations":{"nuc":["A11117G","C12439T","G20002T","G25314T"],"S":["G1251V"],"nsp15":["D128Y"],"nsp6":["I49V"]},"labels":{"aa":"S: G1251V; nsp15: D128Y; nsp6: I49V","spike_mutations":"G1251V"}}},{"name":"AU.3","node_attrs":{"div":23,"Nextclade_pango":{"value":"AU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.585630416870117}},"branch_attrs":{"mutations":{"nuc":["C8109T","C19586T","G29315C"],"N":["D348H"],"nsp14":["T516I"],"nsp3":["T1797I"]},"labels":{"aa":"N: D348H; nsp14: T516I; nsp3: T1797I"}}}]}]}]}]},{"name":"NODE_0000483","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.616693496704102}},"branch_attrs":{"mutations":{"nuc":["G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}},"children":[{"name":"B.1.523","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.523"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.523"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.616693496704102}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000484","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.105329990386963}},"branch_attrs":{"mutations":{"nuc":["T26735C","A28272G"]}},"children":[{"name":"B.1.438.1","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.438.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.438.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.225435256958008}},"branch_attrs":{"mutations":{"nuc":["A1154G","C8152T","A12121G","G23587T","G25677T","G29474T"],"N":["D401Y"],"ORF3a":["L95F"],"S":["Q675H"],"nsp2":["M117V"]},"labels":{"aa":"N: D401Y; ORF3a: L95F; S: Q675H; nsp2: M117V","spike_mutations":"Q675H"}}},{"name":"NODE_0000485","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.198151111602783}},"branch_attrs":{"mutations":{"nuc":["C21846T","A21993-","G23012A","G24410A"],"S":["T95I","Y144-","E484K","D950N"]},"labels":{"aa":"S: T95I, Y144-, E484K, D950N","spike_mutations":"T95I, Y144-, E484K, D950N"}},"children":[{"name":"B.1.625","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.625"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:4-122"},"designation_date":{"value":"2021-06-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.625"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["G521T","C2306T","A4220G","C5730T","C6401T","A10323G","C10775T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12730G","A13712G","C16694T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","T21994-","C22033A","T22882G","G25244T","T26767C","A27721G","A27897-","A27898-","A27899-","T27900-","T27901-"],"M":["I82T"],"ORF7a":["I110V"],"ORF8":["K2-","F3-"],"S":["H69-","V70-","F157L","N440K","V1228L"],"nsp1":["V86F"],"nsp12":["K91R"],"nsp13":["T153I"],"nsp2":["L501F"],"nsp3":["K501E","T1004I","P1228S"],"nsp5":["K90R","P241S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; ORF7a: I110V; ORF8: K2-, F3-; S: H69-, V70-, F157L, N440K, V1228L; nsp1: V86F; nsp12: K91R; nsp13: T153I; nsp2: L501F; nsp3: K501E, T1004I, P1228S; nsp5: K90R, P241S; nsp6: S106-, G107-, F108-","spike_mutations":"H69-, V70-, F157L, N440K, V1228L"}}},{"name":"NODE_0000486","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.621"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-3.4022560119628906}},"branch_attrs":{"mutations":{"nuc":["A3428G","C4878T","C6037T","C10029T","A11451G","A13057T","C17491T","T19035C","C20148T","-21993C","T21995A","G22599A","A23063T","C23604A","G26158-","T26159-","T26160-","A26161-","A26492T","C27925A","C28005T","C28093T","G28272T","C28887T","T28975G"],"N":["T205I","I234M"],"ORF3a":["V256-","N257-"],"ORF8":["T11K","P38S","S67F"],"S":["-144S","Y145N","R346K","N501Y","P681H"],"nsp13":["P419S"],"nsp3":["T237A","T720I"],"nsp4":["T492I"],"nsp6":["Q160R"]},"labels":{"aa":"N: T205I, I234M; ORF3a: V256-, N257-; ORF8: T11K, P38S, S67F; S: -144S, Y145N, R346K, N501Y, P681H; nsp13: P419S; nsp3: T237A, T720I; nsp4: T492I; nsp6: Q160R","clade":"Mu","spike_mutations":"-144S, Y145N, R346K, N501Y, P681H"}},"children":[{"name":"B.1.621","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.621"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-3.4022560119628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000487","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.621"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.116075038909912}},"branch_attrs":{"mutations":{"nuc":["C5192T","C17707T"],"nsp13":["P491S"]},"labels":{"aa":"nsp13: P491S"}},"children":[{"name":"B.1.621.2","node_attrs":{"div":44,"Nextclade_pango":{"value":"B.1.621.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2022-01-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.2"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["T177C","C2700T","T22907A","G23311T","G26959A","A27675C","G29736A","G29779T"],"M":["R146H"],"ORF7a":["Q94H"],"S":["Y449N","E583D"],"nsp2":["T632I"]},"labels":{"aa":"M: R146H; ORF7a: Q94H; S: Y449N, E583D; nsp2: T632I","spike_mutations":"Y449N, E583D"}}},{"name":"NODE_0000488","node_attrs":{"div":43,"Nextclade_pango":{"value":"B.1.621.1"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{"nuc":["A6704G","C9120T","C20402T","T22384A","G26167T","C28657T","T29748C"],"nsp15":["S261L"],"nsp3":["N1329D"],"nsp4":["T189I"]},"labels":{"aa":"nsp15: S261L; nsp3: N1329D; nsp4: T189I"}},"children":[{"name":"B.1.621.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"B.1.621.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{}}},{"name":"BB.2","node_attrs":{"div":47,"Nextclade_pango":{"value":"BB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1.2"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A6708G","C15963T","C24378T","C29409T"],"N":["T379I"],"S":["S939F"],"nsp3":["K1330R"]},"labels":{"aa":"N: T379I; S: S939F; nsp3: K1330R","spike_mutations":"S939F"}}}]}]}]}]}]}]},{"name":"NODE_0000489","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.841441631317139}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}},"children":[{"name":"B.1.468","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.468"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.468"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.841441631317139}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000490","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.1","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.350652694702148}},"branch_attrs":{"mutations":{"nuc":["C11224T","C11941T","C12043T"]}}},{"name":"B.1.36.10","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.10"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.16","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.16"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.127261638641357}},"branch_attrs":{"mutations":{"nuc":["A1T","G25494T"]}}},{"name":"B.1.36.22","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.22"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.22"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.128231525421143}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}}},{"name":"B.1.36.24","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.24"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.24"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.737695217132568}},"branch_attrs":{"mutations":{"nuc":["G22201T"]}}},{"name":"B.1.36.35","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.35"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.653663158416748}},"branch_attrs":{"mutations":{"nuc":["G25440T"],"ORF3a":["K16N"]},"labels":{"aa":"ORF3a: K16N"}}},{"name":"B.1.36.29","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.36.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.29"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8213653564453125}},"branch_attrs":{"mutations":{"nuc":["C3267T","C21034T","G26173T","G28183T","T28277C"],"N":["S2P"],"ORF3a":["E261*"],"ORF8":["S97I"],"nsp16":["L126F"],"nsp3":["T183I"]},"labels":{"aa":"N: S2P; ORF3a: E261*; ORF8: S97I; nsp16: L126F; nsp3: T183I"}}},{"name":"B.1.36.31","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.36.31"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.31"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1722T","A8512G","T9877C","G11222T","C12616T","C15738T","A21868T","C22227T","C25463T","G27561T","C28253T","C29095T"],"ORF3a":["T24I"],"S":["R102S","A222V"],"nsp2":["A306V"],"nsp6":["V84F"]},"labels":{"aa":"ORF3a: T24I; S: R102S, A222V; nsp2: A306V; nsp6: V84F","spike_mutations":"R102S, A222V"}}},{"name":"B.1.36.7","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.7"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.7"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.546401023864746}},"branch_attrs":{"mutations":{"nuc":["A11211G","A22190-","T22191-","T22192-"],"S":["I210-"],"nsp6":["Y80C"]},"labels":{"aa":"S: I210-; nsp6: Y80C","spike_mutations":"I210-"}}},{"name":"B.1.36.8","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.8"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.07541036605835}},"branch_attrs":{"mutations":{"nuc":["A1T","C2836T"]}}},{"name":"B.1.36.9","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.36.9"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["G2035T","C2523T","G3994A","C5730T","C9924T","G11083T","C11109T","A22190-","T22191-","T22192-","C24138A"],"S":["I210-","T859N"],"nsp2":["L410F","T573I"],"nsp3":["T1004I"],"nsp4":["A457V"],"nsp6":["L37F","A46V"]},"labels":{"aa":"S: I210-, T859N; nsp2: L410F, T573I; nsp3: T1004I; nsp4: A457V; nsp6: L37F, A46V","spike_mutations":"I210-, T859N"}}},{"name":"NODE_0000491","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.428178548812866}},"branch_attrs":{"mutations":{"nuc":["T1947C"],"nsp2":["V381A"]},"labels":{"aa":"nsp2: V381A"}},"children":[{"name":"B.1.36.36","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.36.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8934714794158936}},"branch_attrs":{"mutations":{"nuc":["C2668T","G4136T","C12141T","C19512T","C28292A","G29179T"],"N":["Q7K"],"nsp3":["V473F"],"nsp8":["T17I"]},"labels":{"aa":"N: Q7K; nsp3: V473F; nsp8: T17I"}}},{"name":"B.1.36.38","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.38"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.272319793701172}},"branch_attrs":{"mutations":{"nuc":["G22918T"]}}},{"name":"NODE_0000492","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.259950637817383}},"branch_attrs":{"mutations":{"nuc":["C29555T"]}},"children":[{"name":"B.1.36.18","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.36.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.18"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8423047065734863}},"branch_attrs":{"mutations":{"nuc":["G8027T","G15438T","C18981T","G21785C","C28093T"],"ORF8":["S67F"],"S":["G75R"],"nsp12":["M666I"],"nsp3":["V1770F"]},"labels":{"aa":"ORF8: S67F; S: G75R; nsp12: M666I; nsp3: V1770F","spike_mutations":"G75R"}}},{"name":"NODE_0000493","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}},"children":[{"name":"B.1.36.17","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36.17"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.17"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.39","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.36.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.39"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2319C","C6573T","C9936A","C15981T","C25904T"],"ORF3a":["S171L"],"nsp2":["F505S"],"nsp3":["S1285F"],"nsp4":["T461N"]},"labels":{"aa":"ORF3a: S171L; nsp2: F505S; nsp3: S1285F; nsp4: T461N"}}}]}]}]}]}]}]}]},{"name":"NODE_0000494","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-2.8577709197998047}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T"],"ORF3a":["Q57H"],"nsp2":["T85I"]},"labels":{"aa":"ORF3a: Q57H; nsp2: T85I","clade":"20C"}},"children":[{"name":"B.1.298","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.298"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.298"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.423281669616699}},"branch_attrs":{"mutations":{"nuc":["G5012T","C19488T","T28843G"],"N":["S190R"],"nsp3":["V765F"]},"labels":{"aa":"N: S190R; nsp3: V765F"}}},{"name":"B.1.320","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.320"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.320"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.057475566864014}},"branch_attrs":{"mutations":{"nuc":["A1G","C379A"]}}},{"name":"B.1.311","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.311"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.311"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.6200597286224365}},"branch_attrs":{"mutations":{"nuc":["A5011C","C12525T","C27920T","C28893T"],"N":["P207L"],"nsp3":["Q764H"],"nsp8":["T145I"]},"labels":{"aa":"N: P207L; nsp3: Q764H; nsp8: T145I"}}},{"name":"B.1.324","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.324"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.324"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.316860198974609}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}}},{"name":"B.1.319","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.319"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.319"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.238476753234863}},"branch_attrs":{"mutations":{"nuc":["C10851T"],"nsp5":["A266V"]},"labels":{"aa":"nsp5: A266V"}}},{"name":"B.1.340","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.340"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.340"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.6447930335998535}},"branch_attrs":{"mutations":{"nuc":["A4197G","A28715T"],"N":["T148S"],"nsp3":["E493G"]},"labels":{"aa":"N: T148S; nsp3: E493G"}}},{"name":"B.1.346","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.346"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.346"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A12820G","C16762T","A17637G","C20762T","C28887T"],"N":["T205I"],"nsp13":["L176F"],"nsp16":["T35I"]},"labels":{"aa":"N: T205I; nsp13: L176F; nsp16: T35I"}}},{"name":"B.1.350","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.350"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.350"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.54417610168457}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"B.1.349","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.349"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.349"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1025309562683105}},"branch_attrs":{"mutations":{"nuc":["C18555T","C28892T"],"N":["P207S"]},"labels":{"aa":"N: P207S"}}},{"name":"B.1.356","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.356"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.356"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.412571907043457}},"branch_attrs":{"mutations":{"nuc":["T13006C","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}}},{"name":"B.1.362","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.362"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.362"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.247318267822266}},"branch_attrs":{"mutations":{"nuc":["C683T","C6402T","T10249C","G11083T","G17427T","C28854T"],"N":["S194L"],"nsp3":["P1228L"],"nsp6":["L37F"]},"labels":{"aa":"N: S194L; nsp3: P1228L; nsp6: L37F"}}},{"name":"B.1.371","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.371"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.371"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.091424465179443}},"branch_attrs":{"mutations":{"nuc":["G29553A"]}}},{"name":"B.1.433","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.433"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.433"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.620072841644287}},"branch_attrs":{"mutations":{"nuc":["C6843T","T11764C","T17040C","C28887T","G29402T"],"N":["T205I","D377Y"],"nsp3":["S1375F"]},"labels":{"aa":"N: T205I, D377Y; nsp3: S1375F"}}},{"name":"B.1.428","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.428"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.428"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.0384840965271}},"branch_attrs":{"mutations":{"nuc":["C1302T"],"nsp2":["T166I"]},"labels":{"aa":"nsp2: T166I"}}},{"name":"B.1.453","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.453"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.453"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.12796688079834}},"branch_attrs":{"mutations":{"nuc":["C2668T"]}}},{"name":"B.1.566","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.566"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.566"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.346085548400879}},"branch_attrs":{"mutations":{"nuc":["C13860T"]}}},{"name":"B.1.570","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.570"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.570"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.377383708953857}},"branch_attrs":{"mutations":{"nuc":["T7767C","G11087A","C13452T","C21161T","C23604T","G25455T","T29867A","G29868A","C29870A"],"ORF3a":["K21N"],"S":["P681L"],"nsp11":["A4V"],"nsp12":["A4V"],"nsp16":["A168V"],"nsp3":["I1683T"],"nsp6":["E39K"]},"labels":{"aa":"ORF3a: K21N; S: P681L; nsp11: A4V; nsp12: A4V; nsp16: A168V; nsp3: I1683T; nsp6: E39K","spike_mutations":"P681L"}}},{"name":"B.1.576","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.576"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.576"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-2.8577709197998047}},"branch_attrs":{"mutations":{}}},{"name":"B.1.605","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.605"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.605"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C10747T","C13694T","T14103C","C24909A"],"S":["T1116N"],"nsp12":["T85I"]},"labels":{"aa":"S: T1116N; nsp12: T85I","spike_mutations":"T1116N"}}},{"name":"B.1.606","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.606"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.606"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.8544087409973145}},"branch_attrs":{"mutations":{"nuc":["C10015T","G14829T","C23191T","G26769T"],"M":["A83S"],"nsp12":["M463I"]},"labels":{"aa":"M: A83S; nsp12: M463I"}}},{"name":"NODE_0000495","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{"nuc":["C16260T","C28821A"],"N":["S183Y"]},"labels":{"aa":"N: S183Y"}},"children":[{"name":"B.1.369","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.369"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.369"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{"nuc":["A1C"]}}},{"name":"B.1.564","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.564"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.564"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000496","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.185941696166992}},"branch_attrs":{"mutations":{"nuc":["C10582T","C27804T","C28830A"],"N":["S186Y"]},"labels":{"aa":"N: S186Y"}},"children":[{"name":"B.1.367","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.367"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.367"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C3099T","G4960T","C4965T","C6070T","C7303T","C7564T","C9246T","C10279T","C10301A","C10525T","G10688T","G11851T","C14230A","G21800T","G27632T","G29402T","G29779T"],"N":["D377Y"],"ORF7a":["R80I"],"S":["D80Y"],"nsp12":["P264T"],"nsp3":["T127I","T749I"],"nsp4":["A231V"],"nsp5":["Q83K","V212F"],"nsp7":["M3I"]},"labels":{"aa":"N: D377Y; ORF7a: R80I; S: D80Y; nsp12: P264T; nsp3: T127I, T749I; nsp4: A231V; nsp5: Q83K, V212F; nsp7: M3I","spike_mutations":"D80Y"}}},{"name":"B.1.597","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.597"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.597"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.185941696166992}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000497","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.831107139587402}},"branch_attrs":{"mutations":{"nuc":["G17259T","C28887T"],"N":["T205I"],"nsp13":["E341D"]},"labels":{"aa":"N: T205I; nsp13: E341D"}},"children":[{"name":"B.1.375","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.375"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.375"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.301671028137207}},"branch_attrs":{"mutations":{"nuc":["T1171C","A5747G","C10789T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G24007A","C25844T","A26664G"],"M":["I48V"],"ORF3a":["T151I"],"S":["H69-","V70-"],"nsp3":["T1010A"]},"labels":{"aa":"M: I48V; ORF3a: T151I; S: H69-, V70-; nsp3: T1010A","spike_mutations":"H69-, V70-"}}},{"name":"B.1.596.1","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.596.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.596.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["C21780T","G25907T","G28857A"],"N":["R195K"],"ORF3a":["G172V"],"S":["T73I"]},"labels":{"aa":"N: R195K; ORF3a: G172V; S: T73I","spike_mutations":"T73I"}}}]},{"name":"NODE_0000498","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.184943199157715}},"branch_attrs":{"mutations":{"nuc":["A23064C"],"S":["N501T"]},"labels":{"aa":"S: N501T","spike_mutations":"N501T"}},"children":[{"name":"B.1.517","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.517"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.517"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8103365898132324}},"branch_attrs":{"mutations":{"nuc":["G3231T","A12850G","C21364T","C28890T"],"N":["S206F"],"nsp16":["P236S"],"nsp3":["G171V"]},"labels":{"aa":"N: S206F; nsp16: P236S; nsp3: G171V"}}},{"name":"B.1.626","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.626"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.626"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1914A","C2197T","C9142T","C9803T","C10416T","C10908T","G11222T","C13011T","C16961T","C21614T","C21758-","A21759-","T21760-","G21761-","C21762-","T21763-","A21764-","T21765-","A21766-","G22331A","G23012A","T23031C","C24138A","T24364C","C25511T","C25583T","T26767G","C27434T","A28271-","G28280T","C28887T","C29627T","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"M":["I82S"],"N":["D3Y","T205I"],"ORF10":["R24C"],"ORF3a":["S40L","T64I"],"ORF7a":["T14I"],"S":["L18F","H66-","A67-","I68-","G257S","E484K","F490S","T859N"],"nsp13":["P242L"],"nsp2":["R370H"],"nsp5":["S121L","A285V"],"nsp6":["V84F"],"nsp9":["T109I"]},"labels":{"aa":"M: I82S; N: D3Y, T205I; ORF10: R24C; ORF3a: S40L, T64I; ORF7a: T14I; S: L18F, H66-, A67-, I68-, G257S, E484K, F490S, T859N; nsp13: P242L; nsp2: R370H; nsp5: S121L, A285V; nsp6: V84F; nsp9: T109I","spike_mutations":"L18F, H66-, A67-, I68-, G257S, E484K, F490S, T859N"}}}]},{"name":"NODE_0000499","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.420584678649902}},"branch_attrs":{"mutations":{"nuc":["T9867C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C25517T","C27925T","A28271-"],"ORF3a":["P42L"],"ORF8":["T11I"],"nsp4":["L438P"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"ORF3a: P42L; ORF8: T11I; nsp4: L438P; nsp6: S106-, G107-, F108-"}},"children":[{"name":"B.1.526","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.526"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Iota"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21F (Iota)"},"partiallyAliased":{"value":"B.1.526"},"clade_nextstrain":{"value":"21F"},"clade_membership":{"value":"21F"},"placement_prior":{"value":-2.530679702758789}},"branch_attrs":{"mutations":{"nuc":["A16500C","A20262G","C21575T","C21846T","A22320G"],"S":["L5F","T95I","D253G"],"nsp13":["Q88H"]},"labels":{"aa":"S: L5F, T95I, D253G; nsp13: Q88H","clade":"Iota","spike_mutations":"L5F, T95I, D253G"}}},{"name":"B.1.637","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.637"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.637"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.0130152702331543}},"branch_attrs":{"mutations":{"nuc":["A9749G","C9891T","G11804A","A21801G","T21992-","A21993-","T21994-","T22032C","T22917G","C24138A","G24410C","G28044T","C28887T","G28975A"],"N":["T205I","M234I"],"ORF8":["A51S"],"S":["D80G","Y144-","F157S","L452R","T859N","D950H"],"nsp4":["K399E","A446V"],"nsp6":["V278I"]},"labels":{"aa":"N: T205I, M234I; ORF8: A51S; S: D80G, Y144-, F157S, L452R, T859N, D950H; nsp4: K399E, A446V; nsp6: V278I","spike_mutations":"D80G, Y144-, F157S, L452R, T859N, D950H"}}}]},{"name":"NODE_0000500","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.342108726501465}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28887T"],"N":["T205I"],"S":["L452R"]},"labels":{"aa":"N: T205I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"B.1.630","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.630"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.630"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C629T","A1262G","C1627T","G4963T","A5040G","A5648C","C6730T","C6794T","C7768T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T17505C","C19602T","G21255T","C21588T","C21637T","G21969T","T21992-","A21993-","T21994-","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22995G","G23012C","C23525T","G24410A","C25498-","C25499-","G25500-","A25501-","T25502-","A25503-","C25504-","A25505-","A25506-","G25507-","C25508-","C25509-","T25510-","C25511-","A25512-","C25513-","T25514-","C25515-","C25516-","C25517-","T25518-","T25519-","T25520-","C25521-","T25563G","T27796C","C27889T","A28272G","C28512G","G29508A","C29739T"],"N":["P80R","S412N"],"ORF3a":["P36-","I37-","Q38-","A39-","S40-","L41-","P42-","F43-","H57Q"],"ORF7b":["L14S"],"ORF9b":["Q77E"],"S":["P9L","C136F","Y144-","A222V","L242-","A243-","T478R","E484Q","H655Y","D950N"],"nsp1":["L122F"],"nsp2":["T153A"],"nsp3":["R748S","Q774R","K977Q"],"nsp4":["A446V"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P80R, S412N; ORF3a: P36-, I37-, Q38-, A39-, S40-, L41-, P42-, F43-, H57Q; ORF7b: L14S; ORF9b: Q77E; S: P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N; nsp1: L122F; nsp2: T153A; nsp3: R748S, Q774R, K977Q; nsp4: A446V; nsp6: S106-, G107-, F108-","spike_mutations":"P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N"}}},{"name":"21C","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Epsilon"},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["G17014T","G21600T","G22018T","C26681T","A28272T"],"S":["S13I","W152C"],"nsp13":["D260Y"]},"labels":{"aa":"S: S13I, W152C; nsp13: D260Y","clade":"Epsilon","spike_mutations":"S13I, W152C"}},"children":[{"name":"B.1.429","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.429"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Epsilon"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1.429"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-2.493906021118164}},"branch_attrs":{"mutations":{"nuc":["C2395T","T2597C","C8947T","C12100T","A12878G","T24349C","G27890T"],"nsp9":["I65V"]},"labels":{"aa":"nsp9: I65V"}}},{"name":"B.1.427","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.427"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Epsilon"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1.427"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-2.8388147354125977}},"branch_attrs":{"mutations":{"nuc":["G9738C","G13713A","C16394T","C29362T"],"nsp13":["P53L"],"nsp4":["S395T"]},"labels":{"aa":"nsp13: P53L; nsp4: S395T"}}}]}]},{"name":"NODE_0000502","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.435559272766113}},"branch_attrs":{"mutations":{"nuc":["C6730T","T23042C","C23604A"],"S":["S494P","P681H"]},"labels":{"aa":"S: S494P, P681H","spike_mutations":"S494P, P681H"}},"children":[{"name":"B.1.623","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.623"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["T8704C","C9120T","C9870T","C11005A","C12854T","C13458T","G14559A","A23063T","G24893A","A27926-","A27927-","C27928-","T27929-","G27930-","T27931-","A27932-","G27933-","C27934-","T27935-","G27936-","C27937-","A27938-","T27939-","T27940-","T27941-","C27942-","A27943-","C27944-","C27945-","A27946-","A27947-","G27948-","A27949-","A27950-","T27951-","G27952-","T27953-","A27954-","G27955-","A28272T","G28975A"],"N":["M234I"],"ORF8":["T12-","V13-","A14-","A15-","F16-","H17-","Q18-","E19-","C20-","S21-"],"S":["N501Y","E1111K"],"nsp11":["S6L"],"nsp12":["S6L"],"nsp4":["T189I","T439M"],"nsp6":["H11Q"],"nsp9":["P57S"]},"labels":{"aa":"N: M234I; ORF8: T12-, V13-, A14-, A15-, F16-, H17-, Q18-, E19-, C20-, S21-; S: N501Y, E1111K; nsp11: S6L; nsp12: S6L; nsp4: T189I, T439M; nsp6: H11Q; nsp9: P57S","spike_mutations":"N501Y, E1111K"}}},{"name":"NODE_0000503","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.575"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8313353061676025}},"branch_attrs":{"mutations":{"nuc":["A1C","A1180G","C6936T","C10029T","C11514T","C16375T","T20748C","C23709T","T26767C","A28271-","C28887T","G29711-","C29719T"],"M":["I82T"],"N":["T205I"],"S":["T716I"],"nsp13":["P47S"],"nsp3":["S1406F"],"nsp4":["T492I"],"nsp6":["T181I"]},"labels":{"aa":"M: I82T; N: T205I; S: T716I; nsp13: P47S; nsp3: S1406F; nsp4: T492I; nsp6: T181I","spike_mutations":"T716I"}},"children":[{"name":"B.1.575","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.575"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8313353061676025}},"branch_attrs":{"mutations":{}}},{"name":"B.1.575.1","node_attrs":{"div":22,"Nextclade_pango":{"value":"B.1.575.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.6448798179626465}},"branch_attrs":{"mutations":{"nuc":["G29513T","C29614T"],"N":["A414S"]},"labels":{"aa":"N: A414S"}}}]}]},{"name":"NODE_0000504","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.8868496417999268}},"branch_attrs":{"mutations":{"nuc":["G174T","G5230T","A10323G","A21801C","A22206G","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","G22813T","G23012A","A23063T","C23664T","C26456T","C28253T","C28887T"],"E":["P71L"],"N":["T205I"],"S":["D80A","D215G","L241-","L242-","A243-","K417N","E484K","N501Y","A701V"],"nsp3":["K837N"],"nsp5":["K90R"]},"labels":{"aa":"E: P71L; N: T205I; S: D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V; nsp3: K837N; nsp5: K90R","clade":"Beta","spike_mutations":"D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V"}},"children":[{"name":"B.1.351.1","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.351.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.1"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-5.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["C11289G","G11291T","G11292A","T11293C","G11299T","C11300T","T11301A","A11302C","C22513A"],"S":["N317K"],"nsp6":["S106C","G107Y","K109N","L110Y"]},"labels":{"aa":"S: N317K; nsp6: S106C, G107Y, K109N, L110Y","spike_mutations":"N317K"}}},{"name":"NODE_0000505","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.2380783557891846}},"branch_attrs":{"mutations":{"nuc":["C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}},"children":[{"name":"B.1.351","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.351"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.2380783557891846}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-2.969865322113037}},"branch_attrs":{"mutations":{"nuc":["A2692T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C21614T"],"S":["L18F"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"S: L18F; nsp6: S106-, G107-, F108-","spike_mutations":"L18F"}},"children":[{"name":"B.1.351.5","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.351.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.5"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-4.056199073791504}},"branch_attrs":{"mutations":{"nuc":["C664T","G1463T","C16338T","C19019A","C24109T","C24334T","G25660A","C25844T","C26645T","A29406T"],"N":["E378V"],"ORF3a":["V90I","T151I"],"nsp14":["P327Q"],"nsp2":["G220C"]},"labels":{"aa":"N: E378V; ORF3a: V90I, T151I; nsp14: P327Q; nsp2: G220C"}}},{"name":"NODE_0000507","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A8052G","G10396T"],"nsp3":["N1778S"]},"labels":{"aa":"nsp3: N1778S"}},"children":[{"name":"B.1.351.2","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.351.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.2"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C10632T"],"nsp5":["A193V"]},"labels":{"aa":"nsp5: A193V"}}},{"name":"B.1.351.3","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.351.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.3"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-4.018410682678223}},"branch_attrs":{"mutations":{"nuc":["T3G","C6402T","T7624C","C10615T","A16687G"],"nsp13":["I151V"],"nsp3":["P1228L"]},"labels":{"aa":"nsp13: I151V; nsp3: P1228L"}}}]}]}]}]},{"name":"NODE_0000508","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.577651023864746}},"branch_attrs":{"mutations":{"nuc":["A10323G","G28842T"],"N":["S190I"],"nsp5":["K90R"]},"labels":{"aa":"N: S190I; nsp5: K90R"}},"children":[{"name":"B.1.361","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.361"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.361"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.086843013763428}},"branch_attrs":{"mutations":{"nuc":["A705G","G1463A","G11417T","C18167T","A21080G","G29779T"],"nsp1":["D147G"],"nsp14":["P43L"],"nsp16":["K141R"],"nsp2":["G220S"],"nsp6":["V149F"]},"labels":{"aa":"nsp1: D147G; nsp14: P43L; nsp16: K141R; nsp2: G220S; nsp6: V149F"}}},{"name":"B.1.580","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.580"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.580"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.577651023864746}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000509","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{"nuc":["T15276A"]}},"children":[{"name":"B.1.568","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.568"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.568"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.0975661277771}},"branch_attrs":{"mutations":{"nuc":["C5654T","C10450T","C12049T","C12455A","C16428T","C17483T","G25913A","G27916T"],"ORF3a":["G174D"],"ORF8":["G8V"],"nsp13":["T416I"],"nsp8":["L122I"]},"labels":{"aa":"ORF3a: G174D; ORF8: G8V; nsp13: T416I; nsp8: L122I"}}},{"name":"B.1.582","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.582"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.582"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{}}},{"name":"B.1.612","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.612"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.612"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000510","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.043567180633545}},"branch_attrs":{"mutations":{"nuc":["C11916T"],"nsp7":["S25L"]},"labels":{"aa":"nsp7: S25L"}},"children":[{"name":"B.1.3","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.3"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C715T","A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"B.1.497","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.497"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.497"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A1G","C16650T","A20675T","G29179T"],"nsp16":["Q6L"]},"labels":{"aa":"nsp16: Q6L"}}},{"name":"B.1.509","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.509"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.509"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.097189426422119}},"branch_attrs":{"mutations":{"nuc":["C1385T","G1738T","G3242A","C28087T"],"ORF8":["A65V"],"nsp2":["H194Y"],"nsp3":["G175S"]},"labels":{"aa":"ORF8: A65V; nsp2: H194Y; nsp3: G175S"}}},{"name":"NODE_0000511","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8577680587768555}},"branch_attrs":{"mutations":{"nuc":["C18998T","G29540A"],"nsp14":["A320V"]},"labels":{"aa":"nsp14: A320V"}},"children":[{"name":"B.1.499","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.499"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.499"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["C28863T"],"N":["S197L"]},"labels":{"aa":"N: S197L"}}},{"name":"B.1.503","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.503"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.503"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25947C"],"ORF3a":["Q185H"]},"labels":{"aa":"ORF3a: Q185H"}}},{"name":"B.1.505","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.505"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.505"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C66A","C7768T","A8773G","C17304T","T24805C"]}}}]}]},{"name":"NODE_0000512","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.3401401042938232}},"branch_attrs":{"mutations":{"nuc":["C27964T"],"ORF8":["S24L"]},"labels":{"aa":"ORF8: S24L"}},"children":[{"name":"B.1.265","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.265"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.265"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.231685638427734}},"branch_attrs":{"mutations":{"nuc":["C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}}},{"name":"B.1.336","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.336"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.336"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.561881065368652}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}}},{"name":"B.1.426","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.426"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.426"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8296751976013184}},"branch_attrs":{"mutations":{"nuc":["T833C","A22320G"],"S":["D253G"],"nsp2":["F10L"]},"labels":{"aa":"S: D253G; nsp2: F10L","spike_mutations":"D253G"}}},{"name":"NODE_0000513","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.462985992431641}},"branch_attrs":{"mutations":{"nuc":["A18424G","G25907T"],"ORF3a":["G172V"],"nsp14":["N129D"]},"labels":{"aa":"ORF3a: G172V; nsp14: N129D"}},"children":[{"name":"B.1.2","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20G"},"partiallyAliased":{"value":"B.1.2"},"clade_nextstrain":{"value":"20G"},"clade_membership":{"value":"20G"},"placement_prior":{"value":-2.0290451049804688}},"branch_attrs":{"mutations":{"nuc":["C10319T","C21304T","C28472T","C28869T"],"N":["P67S","P199L"],"nsp16":["R216C"],"nsp5":["L89F"]},"labels":{"aa":"N: P67S, P199L; nsp16: R216C; nsp5: L89F","clade":"20G"}}},{"name":"B.1.596","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.596"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.596"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.462985992431641}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000514","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7341673374176025}},"branch_attrs":{"mutations":{"nuc":["C10319T"],"nsp5":["L89F"]},"labels":{"aa":"nsp5: L89F"}},"children":[{"name":"B.1.567","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.567"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.567"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.657742500305176}},"branch_attrs":{"mutations":{"nuc":["C11575T","A20262G","G21305A","C28868T"],"N":["P199S"],"nsp16":["R216H"]},"labels":{"aa":"N: P199S; nsp16: R216H"}}},{"name":"B.1.577","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.577"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8689005374908447}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"nsp13":["T153I"]},"labels":{"aa":"nsp13: T153I"}}},{"name":"B.1.595","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.595"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.595"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7341673374176025}},"branch_attrs":{"mutations":{"nuc":["A1G"]}}},{"name":"NODE_0000515","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.714270114898682}},"branch_attrs":{"mutations":{"nuc":["G6052A","G19872T","G25855T","G29254T","G29474T"],"N":["D401Y"],"ORF3a":["D155Y"]},"labels":{"aa":"N: D401Y; ORF3a: D155Y"}},"children":[{"name":"B.1.587","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.587"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.587"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.290242671966553}},"branch_attrs":{"mutations":{"nuc":["T5122C","G20102T","C20117T","A22095G"],"S":["D178G"],"nsp15":["S161I","T166I"]},"labels":{"aa":"S: D178G; nsp15: S161I, T166I","spike_mutations":"D178G"}}},{"name":"B.1.588","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.588"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{"nuc":["C7600T","G7675C","C21621T","G22201T","G28975T","G29764T"],"N":["M234I"],"S":["T20I"]},"labels":{"aa":"N: M234I; S: T20I","spike_mutations":"T20I"}}}]}]}]}]},{"name":"NODE_0000516","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.617"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.895909309387207}},"branch_attrs":{"mutations":{"nuc":["G210T","T22917G","C23604G","T27638C","G28881T","G29402T","G29742T"],"N":["R203M","D377Y"],"ORF7a":["V82A"],"S":["T19R","L452R","P681R"]},"labels":{"aa":"N: R203M, D377Y; ORF7a: V82A; S: T19R, L452R, P681R","spike_mutations":"T19R, L452R, P681R"}},"children":[{"name":"B.1.617.3","node_attrs":{"div":22,"Nextclade_pango":{"value":"B.1.617.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C835T","C7296T","C8208T","G10634T","C11322T","C16293T","C21618G","G23012C","T27384C","C27970T","C28472T"],"N":["P67S"],"ORF8":["T26I"],"S":["E484Q"],"nsp3":["A1526V","T1830I"],"nsp5":["A194S"],"nsp6":["A117V"]},"labels":{"aa":"N: P67S; ORF8: T26I; S: E484Q; nsp3: A1526V, T1830I; nsp5: A194S; nsp6: A117V","spike_mutations":"E484Q"}}},{"name":"internal_d736","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.617"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.2567901611328125}},"branch_attrs":{"mutations":{"nuc":["G21987A","C25469T"],"ORF3a":["S26L"],"S":["G142D"]},"labels":{"aa":"ORF3a: S26L; S: G142D","spike_mutations":"G142D"}},"children":[{"name":"B.1.617.1","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.617.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Kappa"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21B (Kappa)"},"partiallyAliased":{"value":"B.1.617.1"},"clade_nextstrain":{"value":"21B"},"clade_membership":{"value":"21B"},"placement_prior":{"value":-3.281346321105957}},"branch_attrs":{"mutations":{"nuc":["C3457T","C4965T","A11201G","G17523T","A20396G","T21895C","G22022A","G23012C","C26681T","T26767G"],"M":["I82S"],"S":["R19T","E154K","E484Q"],"nsp13":["M429I"],"nsp15":["K259R"],"nsp3":["T749I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82S; S: R19T, E154K, E484Q; nsp13: M429I; nsp15: K259R; nsp3: T749I; nsp6: T77A","clade":"Kappa","spike_mutations":"R19T, E154K, E484Q"}}},{"name":"NODE_0000518","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.928345203399658}},"branch_attrs":{"mutations":{"nuc":["C21618G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22995A","G24410A","T26767C","C27752T","A28271-","A28461G"],"M":["I82T"],"N":["D63G"],"ORF7a":["T120I"],"ORF9b":["T60A"],"S":["E156-","F157-","R158G","T478K","D950N"]},"labels":{"aa":"M: I82T; N: D63G; ORF7a: T120I; ORF9b: T60A; S: E156-, F157-, R158G, T478K, D950N","clade":"Delta","spike_mutations":"E156-, F157-, R158G, T478K, D950N"}},"children":[{"name":"NODE_0000519","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.125234365463257}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","C5184T","G9203A","T9678C","C11005A","A17496G","A20396G","A21792C","C28253T"],"S":["K77T"],"nsp15":["K259R"],"nsp2":["P129L"],"nsp3":["P822L"],"nsp4":["D217N","F375S"],"nsp6":["H11Q"]},"labels":{"aa":"S: K77T; nsp15: K259R; nsp2: P129L; nsp3: P822L; nsp4: D217N, F375S; nsp6: H11Q","spike_mutations":"K77T"}},"children":[{"name":"AY.35","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.35"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.42242431640625}},"branch_attrs":{"mutations":{"nuc":["A1C","C6027A","C13989T","C16915T","G23012C"],"S":["E484Q"],"nsp3":["P1103Q"]},"labels":{"aa":"S: E484Q; nsp3: P1103Q","spike_mutations":"E484Q"}}},{"name":"AY.48","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.48"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.48"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A10399G","C10868T","G27948T"],"ORF8":["E19*"]},"labels":{"aa":"ORF8: E19*"}}}]},{"name":"NODE_0000520","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.281507730484009}},"branch_attrs":{"mutations":{"nuc":["G15451A","C16466T"],"nsp12":["G671S"],"nsp13":["P77L"]},"labels":{"aa":"nsp12: G671S; nsp13: P77L"}},"children":[{"name":"B.1.617.2","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.617.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.281507730484009}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000521","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.9130396842956543}},"branch_attrs":{"mutations":{"nuc":["C5184T","C9891T","T11418C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-"],"ORF8":["D119-","F120-"],"nsp3":["P822L"],"nsp4":["A446V"],"nsp6":["V149A"]},"labels":{"aa":"ORF8: D119-, F120-; nsp3: P822L; nsp4: A446V; nsp6: V149A"}},"children":[{"name":"NODE_0000522","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.995262622833252}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","T12946C","A20262G","C27739T"],"ORF7a":["L116F"],"nsp2":["P129L"]},"labels":{"aa":"ORF7a: L116F; nsp2: P129L"}},"children":[{"name":"NODE_0000523","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.093592882156372}},"branch_attrs":{"mutations":{"nuc":["C6539T","C20320T","C24745T","G28690T","G29427A"],"N":["L139F","R385K"],"nsp15":["H234Y"],"nsp3":["H1274Y"]},"labels":{"aa":"N: L139F, R385K; nsp15: H234Y; nsp3: H1274Y"}},"children":[{"name":"AY.30","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.30"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.30"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.6562893390655518}},"branch_attrs":{"mutations":{"nuc":["C9319T","A13482G","-28271A","G29781T"]}}},{"name":"AY.40","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.40"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.40"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["A1558G","C1912T","G2755T","A15892G","G23282T","C28099T","T28297C"],"ORF8":["S69L"],"ORF9b":["I5T"],"S":["D574Y"],"nsp12":["M818V"],"nsp2":["I251M"]},"labels":{"aa":"ORF8: S69L; ORF9b: I5T; S: D574Y; nsp12: M818V; nsp2: I251M","spike_mutations":"D574Y"}}}]},{"name":"NODE_0000524","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.395604133605957}},"branch_attrs":{"mutations":{"nuc":["C18176T"],"nsp14":["P46L"]},"labels":{"aa":"nsp14: P46L"}},"children":[{"name":"AY.49","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.49"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF3a:30-276"},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.frameShifts":{"value":"ORF3a:30-276"},"qc.frameShifts.totalFrameShifts":{"value":1},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.49"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T5773C","C10834T","C23039G","G24124T","G25471-","A25472-","T25473-","T25474-","T25475-","T25476-","G25477-","T25478-","C26110T","A27979T"],"ORF3a":["L26-","D27-","F28-","V29-"],"ORF8":["Q29L"],"S":["Q493E","K854N"]},"labels":{"aa":"ORF3a: L26-, D27-, F28-, V29-; ORF8: Q29L; S: Q493E, K854N","spike_mutations":"Q493E, K854N"}}},{"name":"AY.50","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.50"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.50"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C884T","C5730T","C19554T","G22484C","-28271A","G28809T"],"N":["G179V"],"S":["V308L"],"nsp2":["R27C"],"nsp3":["T1004I"]},"labels":{"aa":"N: G179V; S: V308L; nsp2: R27C; nsp3: T1004I","spike_mutations":"V308L"}}},{"name":"AY.53","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.53"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.53"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.5879409313201904}},"branch_attrs":{"mutations":{"nuc":["G1738T","A2292C","C18348T","C20031T","G21641T"],"S":["A27S"],"nsp2":["Q496P"]},"labels":{"aa":"S: A27S; nsp2: Q496P","spike_mutations":"A27S"}}},{"name":"AY.52","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.52"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.52"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["T24984G","T25689C","G26428T","C26858T","C28419T"],"E":["V62F"],"N":["T49I"],"S":["L1141W"]},"labels":{"aa":"E: V62F; N: T49I; S: L1141W","spike_mutations":"L1141W"}}},{"name":"AY.8","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.8"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.8487331867218018}},"branch_attrs":{"mutations":{"nuc":["C11455T","A14170G"],"nsp12":["I244V"]},"labels":{"aa":"nsp12: I244V"}}},{"name":"NODE_0000525","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.849754571914673}},"branch_attrs":{"mutations":{"nuc":["A18468G"]}},"children":[{"name":"AY.13","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.13"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.3170342445373535}},"branch_attrs":{"mutations":{"nuc":["A17406G","C29095T"]}}},{"name":"NODE_0000526","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.16"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{"nuc":["T26076A"]}},"children":[{"name":"AY.16.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16.1"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C8407T","A12417G","G12911A","C14913T","T29867A"],"nsp8":["N109S"],"nsp9":["V76I"]},"labels":{"aa":"nsp8: N109S; nsp9: V76I"}}},{"name":"AY.16","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000527","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.429879188537598}},"branch_attrs":{"mutations":{"nuc":["C19160T"],"nsp14":["S374F"]},"labels":{"aa":"nsp14: S374F"}},"children":[{"name":"AY.14","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.14"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.0154049396514893}},"branch_attrs":{"mutations":{"nuc":["T1877G","G20718T"],"nsp16":["M20I"],"nsp2":["S358A"]},"labels":{"aa":"nsp16: M20I; nsp2: S358A"}}},{"name":"AY.15","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.15"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.385550022125244}},"branch_attrs":{"mutations":{"nuc":["A16872G","G27382C","-28271A"],"ORF6":["D61H"]},"labels":{"aa":"ORF6: D61H"}}},{"name":"AY.54","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.54"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.54"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.0774950981140137}},"branch_attrs":{"mutations":{"nuc":["A1G","C193T","G14187A","A25806G"]}}}]},{"name":"NODE_0000528","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.0211334228515625}},"branch_attrs":{"mutations":{"nuc":["A25562G"],"ORF3a":["Q57R"]},"labels":{"aa":"ORF3a: Q57R"}},"children":[{"name":"AY.19","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.19"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.19"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25019T","G25947T","-28271A"],"ORF3a":["Q185H"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: Q185H; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"AY.17","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.17"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2240G","C14708T","C17436T","-28271A"],"nsp12":["A423V"],"nsp2":["I479V"]},"labels":{"aa":"nsp12: A423V; nsp2: I479V"}}},{"name":"AY.51","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.51"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.51"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.137358665466309}},"branch_attrs":{"mutations":{"nuc":["G12223T","A25697T"],"ORF3a":["E102V"]},"labels":{"aa":"ORF3a: E102V"}}}]}]}]},{"name":"NODE_0000529","node_attrs":{"div":26,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6166188716888428}},"branch_attrs":{"mutations":{"nuc":["C11514T","C22227T"],"S":["A222V"],"nsp6":["T181I"]},"labels":{"aa":"S: A222V; nsp6: T181I","clade":"21I","spike_mutations":"A222V"}},"children":[{"name":"AY.62","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.62"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.62"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["A1045T","G1820A","A20085G","C28093T","G29440A"],"ORF8":["S67F"],"nsp2":["G339S"]},"labels":{"aa":"ORF8: S67F; nsp2: G339S"}}},{"name":"NODE_0000530","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6697630882263184}},"branch_attrs":{"mutations":{"nuc":["A5584G"]}},"children":[{"name":"AY.24","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.24"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.24"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.5928659439086914}},"branch_attrs":{"mutations":{"nuc":["C23896T","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"NODE_0000531","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.90034556388855}},"branch_attrs":{"mutations":{"nuc":["C13019T"]}},"children":[{"name":"AY.10","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.10"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.07296895980835}},"branch_attrs":{"mutations":{"nuc":["G219T","A8651G","G9526T","C12756T","C13665T","A23734G"],"nsp4":["M33V","M324I"],"nsp9":["T24I"]},"labels":{"aa":"nsp4: M33V, M324I; nsp9: T24I"}}},{"name":"AY.11","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.11"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.418825149536133}},"branch_attrs":{"mutations":{"nuc":["C3486T","C18526T","T19516C","G26526T","C29509T"],"M":["A2S"],"nsp14":["R163C"],"nsp3":["A256V"]},"labels":{"aa":"M: A2S; nsp14: R163C; nsp3: A256V"}}},{"name":"AY.28","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.28"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.28"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C335T","G2167T","C8950T","C9246T","G23663T","G24794T","G25855T"],"ORF3a":["D155Y"],"S":["A701S","A1078S"],"nsp1":["R24C"],"nsp2":["K454N"],"nsp4":["A231V"]},"labels":{"aa":"ORF3a: D155Y; S: A701S, A1078S; nsp1: R24C; nsp2: K454N; nsp4: A231V","spike_mutations":"A701S, A1078S"}}},{"name":"AY.27","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.27"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.27"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.8427717685699463}},"branch_attrs":{"mutations":{"nuc":["T11938C","A14475G","G29422T"]}}},{"name":"AY.47","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.47"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.47"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.620307445526123}},"branch_attrs":{"mutations":{"nuc":["C1684T","G5164T","C12049T","G22427A","G28326T"],"N":["G18V"],"ORF9b":["V15L"],"S":["V289I"],"nsp3":["E815D"]},"labels":{"aa":"N: G18V; ORF9b: V15L; S: V289I; nsp3: E815D","spike_mutations":"V289I"}}},{"name":"AY.55","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.55"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.55"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.71439266204834}},"branch_attrs":{"mutations":{"nuc":["A10978G","-28271A"]}}},{"name":"AY.57","node_attrs":{"div":30,"Nextclade_pango":{"value":"AY.57"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.57"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.764986515045166}},"branch_attrs":{"mutations":{"nuc":["C1403T","G5584T"],"nsp2":["P200S"]},"labels":{"aa":"nsp2: P200S"}}},{"name":"AY.56","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.56"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.56"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3634T","C25624T","G27870T"],"ORF3a":["H78Y"],"ORF7b":["E39*"]},"labels":{"aa":"ORF3a: H78Y; ORF7b: E39*"}}},{"name":"AY.59","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.59"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.59"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C19164T","T20391G","C21302T"],"nsp16":["P215L"]},"labels":{"aa":"nsp16: P215L"}}},{"name":"AY.61","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.61"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.61"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.942255735397339}},"branch_attrs":{"mutations":{"nuc":["T25532C"],"ORF3a":["I47T"]},"labels":{"aa":"ORF3a: I47T"}}},{"name":"AY.60","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.60"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.60"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A2165C","C2919T","G4162T","T8634C","T12056A","T13701C","G17122T"],"nsp13":["A296S"],"nsp2":["K454Q"],"nsp3":["P67L"],"nsp4":["I27T"],"nsp7":["C72S"]},"labels":{"aa":"nsp13: A296S; nsp2: K454Q; nsp3: P67L; nsp4: I27T; nsp7: C72S"}}},{"name":"AY.64","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.64"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.64"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.9437766075134277}},"branch_attrs":{"mutations":{"nuc":["T2C","C346T","C5784T","C6388T","C24130T","G25135T","G25691T","C27005T","G29254T","G29688T"],"ORF3a":["G100V"],"S":["K1191N"],"nsp3":["T1022I"]},"labels":{"aa":"ORF3a: G100V; S: K1191N; nsp3: T1022I","spike_mutations":"K1191N"}}},{"name":"AY.68","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.68"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.68"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.760132312774658}},"branch_attrs":{"mutations":{"nuc":["G105T","C3294T","C8208T","C14362T","C19524T","A22320C","T24499A","C25782T","A26891G","T27878C"],"S":["D253A","D979E"],"nsp3":["P192L","T1830I"]},"labels":{"aa":"S: D253A, D979E; nsp3: P192L, T1830I","spike_mutations":"D253A, D979E"}}},{"name":"AY.67","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.67"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.67"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8576669692993164}},"branch_attrs":{"mutations":{"nuc":["C4890T","T5644C","T19519C","A27368G"],"ORF6":["Q56R"],"nsp14":["Y494H"],"nsp3":["T724I"]},"labels":{"aa":"ORF6: Q56R; nsp14: Y494H; nsp3: T724I"}}},{"name":"AY.66","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.66"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.66"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T13C","T6496C","G14874T","C28892T"],"N":["P207S"],"nsp12":["K478N"]},"labels":{"aa":"N: P207S; nsp12: K478N"}}},{"name":"AY.69","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.69"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.69"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C3984T","A4405T","A4838G","G9431A","G16864A","G17847A","G25720T","C27559T"],"ORF3a":["A110S"],"nsp13":["V210I"],"nsp3":["T422I","I707V"],"nsp4":["V293I"]},"labels":{"aa":"ORF3a: A110S; nsp13: V210I; nsp3: T422I, I707V; nsp4: V293I"}}},{"name":"AY.70","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.70"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.70"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.4444901943206787}},"branch_attrs":{"mutations":{"nuc":["C4891T","G21255T","G21624C","G28899T","G28903T"],"N":["R209I","M210I"],"S":["R21T"]},"labels":{"aa":"N: R209I, M210I; S: R21T","spike_mutations":"R21T"}}},{"name":"NODE_0000532","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.80359411239624}},"branch_attrs":{"mutations":{"nuc":["C5192T"]}},"children":[{"name":"AY.58","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.58"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.58"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["G8540A","C26079A","C27131T"],"nsp3":["A1941T"]},"labels":{"aa":"nsp3: A1941T"}}},{"name":"AY.63","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.63"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.63"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.740610122680664}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","A7886G","C8964T","C9857T","C13335T","A14246G","A19126G","A23848G","C25710T","G29616T","T29728C"],"ORF10":["R20I"],"nsp1":["K141-","S142-","F143-"],"nsp10":["A104V"],"nsp12":["D269G"],"nsp14":["I363V"],"nsp3":["I1723V"],"nsp4":["S137L"]},"labels":{"aa":"ORF10: R20I; nsp1: K141-, S142-, F143-; nsp10: A104V; nsp12: D269G; nsp14: I363V; nsp3: I1723V; nsp4: S137L"}}}]},{"name":"NODE_0000533","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.75"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1813862323760986}},"branch_attrs":{"mutations":{"nuc":["C21622T"]}},"children":[{"name":"AY.75","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.75"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1813862323760986}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000534","node_attrs":{"div":30,"Nextclade_pango":{"value":"AY.75"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.644587278366089}},"branch_attrs":{"mutations":{"nuc":["G29744A"]}},"children":[{"name":"AY.75.2","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.75.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T13C","T7717C","A16824G","A21987G","G23611T"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}}},{"name":"AY.75.3","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.75.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75.3"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T322C","C1329A","G8428A","G16873A","T19127C","C22314T"],"S":["P251L"],"nsp13":["G213S"],"nsp14":["I363T"],"nsp2":["T175N"]},"labels":{"aa":"S: P251L; nsp13: G213S; nsp14: I363T; nsp2: T175N","spike_mutations":"P251L"}}}]}]},{"name":"NODE_0000535","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.9"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.33573317527771}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"AY.9","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.33573317527771}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000536","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.9.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.80546498298645}},"branch_attrs":{"mutations":{"nuc":["G1729A","G14030A","C18086T"],"nsp12":["R197Q"],"nsp14":["T16I"]},"labels":{"aa":"nsp12: R197Q; nsp14: T16I"}},"children":[{"name":"AY.9.2.2","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.9.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6840121746063232}},"branch_attrs":{"mutations":{"nuc":["C4321T","A9685G","C23585A"],"S":["Q675K"],"nsp4":["I377M"]},"labels":{"aa":"S: Q675K; nsp4: I377M","spike_mutations":"Q675K"}}},{"name":"AY.9.2","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.80546498298645}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000537","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.977773427963257}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.133","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.133"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C203T","C449T","C4763T","C12025T","C20104T","T21613A","C21614T","C23058G","C24370T","T25333C","T29867A"],"S":["N17K","L18F","P499R"],"nsp1":["P62S"],"nsp15":["L162F"],"nsp3":["H682Y"]},"labels":{"aa":"S: N17K, L18F, P499R; nsp1: P62S; nsp15: L162F; nsp3: H682Y","spike_mutations":"N17K, L18F, P499R"}}},{"name":"NODE_0000538","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T13019C"]}},"children":[{"name":"AY.65","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.65"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:121-122"},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.65"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G14028T","C27005T","-28253T","-28271A"],"nsp12":["M196I"]},"labels":{"aa":"nsp12: M196I"}}},{"name":"NODE_0000539","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.26"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.016456365585327}},"branch_attrs":{"mutations":{"nuc":["A27345T"],"ORF6":["K48N"]},"labels":{"aa":"ORF6: K48N"}},"children":[{"name":"AY.26","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.26"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.016456365585327}},"branch_attrs":{"mutations":{}}},{"name":"AY.26.1","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26.1"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G20580T","A21987G","G23012C","A24587T","G26529C","G27703T","C29769T"],"M":["D3H"],"ORF7a":["V104F"],"S":["D142G","E484Q","T1009S"]},"labels":{"aa":"M: D3H; ORF7a: V104F; S: D142G, E484Q, T1009S","spike_mutations":"D142G, E484Q, T1009S"}}}]}]}]},{"name":"NODE_0000540","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1191558837890625}},"branch_attrs":{"mutations":{"nuc":["C2509T"]}},"children":[{"name":"AY.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6743457317352295}},"branch_attrs":{"mutations":{"nuc":["A1G","T3055C","G3701A","C17336T","C18570T","G21770T","G22813T","T29867A","G29868A"],"S":["V70F","K417N"],"nsp13":["T367I"],"nsp3":["A328T"]},"labels":{"aa":"S: V70F, K417N; nsp13: T367I; nsp3: A328T","spike_mutations":"V70F, K417N"}}},{"name":"AY.37","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.37"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.37"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6478559970855713}},"branch_attrs":{"mutations":{"nuc":["G2185T","T20911C"],"nsp2":["E460D"]},"labels":{"aa":"nsp2: E460D"}}},{"name":"AY.38","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.38"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.963697910308838}},"branch_attrs":{"mutations":{"nuc":["G15760T","A22310T","-28271A","G29212T","T29742G"],"S":["T250S"],"nsp12":["G774C"]},"labels":{"aa":"S: T250S; nsp12: G774C","spike_mutations":"T250S"}}},{"name":"AY.71","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.71"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.71"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8321352005004883}},"branch_attrs":{"mutations":{"nuc":["A1T","C25317T","-28271A"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"NODE_0000541","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.954825401306152}},"branch_attrs":{"mutations":{"nuc":["G5539A"]}},"children":[{"name":"AY.73","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.73"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.73"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.9488861560821533}},"branch_attrs":{"mutations":{"nuc":["C222T","C6573T","C27657T","C28409T","C28893T"],"N":["P46S","P207L"],"nsp3":["S1285F"]},"labels":{"aa":"N: P46S, P207L; nsp3: S1285F"}}},{"name":"AY.72","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.72"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.72"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.11883020401001}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G6080T","A25856G","C26013T"],"ORF3a":["D155G"],"nsp1":["K141-","S142-","F143-"],"nsp3":["D1121Y"]},"labels":{"aa":"ORF3a: D155G; nsp1: K141-, S142-, F143-; nsp3: D1121Y"}}},{"name":"AY.74","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.74"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.74"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1409428119659424}},"branch_attrs":{"mutations":{"nuc":["G3994A","C25413T","G29392T"],"N":["K373N"]},"labels":{"aa":"N: K373N"}}}]}]}]}]}]}]},{"name":"NODE_0000542","node_attrs":{"div":32,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1918766498565674}},"branch_attrs":{"mutations":{"nuc":["G4181T","C6402T","C7124T","C8986T","C10029T","A11201G","A11332G","C19220T","C21846T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","G28916T"],"N":["G215C"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"S":["T95I"],"nsp14":["A394V"],"nsp3":["A488S","P1228L","P1469S"],"nsp4":["T492I"],"nsp6":["T77A"]},"labels":{"aa":"N: G215C; ORF7b: T40I; ORF8: D119-, F120-; S: T95I; nsp14: A394V; nsp3: A488S, P1228L, P1469S; nsp4: T492I; nsp6: T77A","clade":"21J","spike_mutations":"T95I"}},"children":[{"name":"AY.78","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.78"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.78"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.552331924438477}},"branch_attrs":{"mutations":{"nuc":["T13188C","G14874T","G15372T","-28271A","C29200T","G29227A"],"nsp10":["I55T"],"nsp12":["K478N"]},"labels":{"aa":"nsp10: I55T; nsp12: K478N"}}},{"name":"NODE_0000543","node_attrs":{"div":33,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.0917282104492188}},"branch_attrs":{"mutations":{"nuc":["G9053T"],"nsp4":["V167L"]},"labels":{"aa":"nsp4: V167L"}},"children":[{"name":"AY.1","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5589118003845215}},"branch_attrs":{"mutations":{"nuc":["G22335T","G22813T"],"S":["W258L","K417N"]},"labels":{"aa":"S: W258L, K417N","spike_mutations":"W258L, K417N"}}},{"name":"AY.105","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.105"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.105"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.082991123199463}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2939T"],"nsp3":["P74S"]},"labels":{"aa":"nsp3: P74S"}}},{"name":"AY.106","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.106"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.106"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6580145359039307}},"branch_attrs":{"mutations":{"nuc":["C9811T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"AY.109","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.109"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6555285453796387}},"branch_attrs":{"mutations":{"nuc":["A11595G","A14836G","T21846C","C27549T"],"S":["I95T"],"nsp12":["I466V"],"nsp6":["Q208R"]},"labels":{"aa":"S: I95T; nsp12: I466V; nsp6: Q208R","spike_mutations":"I95T"}}},{"name":"AY.107","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.107"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.107"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4870200157165527}},"branch_attrs":{"mutations":{"nuc":["A15012G","C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"AY.110","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.110"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.110"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.568274736404419}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","C912A"],"nsp1":["K141-","S142-","F143-"],"nsp2":["S36Y"]},"labels":{"aa":"nsp1: K141-, S142-, F143-; nsp2: S36Y"}}},{"name":"AY.112","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.112"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.112"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.2281134128570557}},"branch_attrs":{"mutations":{"nuc":["G25647T","-28271A"],"ORF3a":["L85F"]},"labels":{"aa":"ORF3a: L85F"}}},{"name":"AY.111","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.111"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.194126844406128}},"branch_attrs":{"mutations":{"nuc":["C4456T"]}}},{"name":"AY.117","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.117"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.117"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.009012460708618}},"branch_attrs":{"mutations":{"nuc":["A1G","G2202T","G14186T","C15810T","C28708T"],"nsp12":["R249M"],"nsp2":["W466L"]},"labels":{"aa":"nsp12: R249M; nsp2: W466L"}}},{"name":"AY.118","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.118"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.8720552921295166}},"branch_attrs":{"mutations":{"nuc":["A1C","T826C","A27338T"],"ORF6":["E46V"]},"labels":{"aa":"ORF6: E46V"}}},{"name":"AY.126","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.126"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.126"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6271045207977295}},"branch_attrs":{"mutations":{"nuc":["A1T","C14925T","A21137G","A24110C","A25439C"],"ORF3a":["K16T"],"S":["I850L"],"nsp16":["K160R"]},"labels":{"aa":"ORF3a: K16T; S: I850L; nsp16: K160R","spike_mutations":"I850L"}}},{"name":"AY.128","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.128"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.128"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.377318859100342}},"branch_attrs":{"mutations":{"nuc":["C2973T","G15906T","G16795T","T28150C"],"ORF8":["F86S"],"nsp12":["Q822H"],"nsp13":["V187L"],"nsp3":["A85V"]},"labels":{"aa":"ORF8: F86S; nsp12: Q822H; nsp13: V187L; nsp3: A85V"}}},{"name":"AY.129","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.129"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.129"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.10140061378479}},"branch_attrs":{"mutations":{"nuc":["A21194G","G28001T","T28156C"],"ORF8":["I88T"],"nsp16":["D179G"]},"labels":{"aa":"ORF8: I88T; nsp16: D179G"}}},{"name":"AY.132","node_attrs":{"div":48,"Nextclade_pango":{"value":"AY.132"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.132"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.301616191864014}},"branch_attrs":{"mutations":{"nuc":["G1418A","A2172G","C4754T","C7945T","G11161A","T11488C","G18213A","T19500C","A19908G","C23683T","C25710T","G25855T","C27131T","G27870T","C27881A"],"ORF3a":["D155Y"],"ORF7b":["E39*","H42Q"],"nsp14":["M58I"],"nsp15":["I96M"],"nsp2":["A205T","K456R"],"nsp3":["P679S"]},"labels":{"aa":"ORF3a: D155Y; ORF7b: E39*, H42Q; nsp14: M58I; nsp15: I96M; nsp2: A205T, K456R; nsp3: P679S"}}},{"name":"AY.131","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.131"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.789443492889404}},"branch_attrs":{"mutations":{"nuc":["C14407T","G19999T","G22899T","A23064C","T29014C","G29688T"],"S":["G446V","N501T"],"nsp12":["L323F"],"nsp15":["V127F"]},"labels":{"aa":"S: G446V, N501T; nsp12: L323F; nsp15: V127F","spike_mutations":"G446V, N501T"}}},{"name":"AY.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.4940871000289917}},"branch_attrs":{"mutations":{"nuc":["C7851T"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}}},{"name":"AY.4.10","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.4.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.10"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9287588596343994}},"branch_attrs":{"mutations":{"nuc":["C4320T","C5512T","C7851T","T8604C","C10714T","C12513T","A16602G","G20663A","C23996T","G25757T","T27900C"],"ORF3a":["R122I"],"ORF8":["F3L"],"S":["P812S"],"nsp16":["S2N"],"nsp3":["A534V","A1711V"],"nsp4":["F17S"],"nsp8":["T141M"]},"labels":{"aa":"ORF3a: R122I; ORF8: F3L; S: P812S; nsp16: S2N; nsp3: A534V, A1711V; nsp4: F17S; nsp8: T141M","spike_mutations":"P812S"}}},{"name":"AY.4.3","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.506161689758301}},"branch_attrs":{"mutations":{"nuc":["C7851T","C21638T"],"S":["P26S"],"nsp3":["A1711V"]},"labels":{"aa":"S: P26S; nsp3: A1711V","spike_mutations":"P26S"}}},{"name":"AY.4.4","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6225411891937256}},"branch_attrs":{"mutations":{"nuc":["C7851T","G14209T","C21575T","C22000T","G24348C"],"S":["L5F","S929T"],"nsp12":["V257F"],"nsp3":["A1711V"]},"labels":{"aa":"S: L5F, S929T; nsp12: V257F; nsp3: A1711V","spike_mutations":"L5F, S929T"}}},{"name":"AY.4.5","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9815378189086914}},"branch_attrs":{"mutations":{"nuc":["C7851T","A14882C","G25337T"],"S":["D1259Y"],"nsp12":["D481A"],"nsp3":["A1711V"]},"labels":{"aa":"S: D1259Y; nsp12: D481A; nsp3: A1711V","spike_mutations":"D1259Y"}}},{"name":"AY.4.8","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.8"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.532318115234375}},"branch_attrs":{"mutations":{"nuc":["C2706T","C7851T","C11450A","A12124G","G25489T","C29774T"],"ORF3a":["A33S"],"nsp2":["T634I"],"nsp3":["A1711V"],"nsp6":["Q160K"]},"labels":{"aa":"ORF3a: A33S; nsp2: T634I; nsp3: A1711V; nsp6: Q160K"}}},{"name":"AY.4.7","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.366204261779785}},"branch_attrs":{"mutations":{"nuc":["A1T","C7851T","G14829T","G17193T","G26416T","C28291T"],"E":["V58F"],"ORF9b":["P3L"],"nsp12":["M463I"],"nsp13":["E319D"],"nsp3":["A1711V"]},"labels":{"aa":"E: V58F; ORF9b: P3L; nsp12: M463I; nsp13: E319D; nsp3: A1711V"}}},{"name":"AY.44","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.44"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.44"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.8040610551834106}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14014G","T21846C","A29700G"],"S":["I95T"],"nsp12":["F192V"]},"labels":{"aa":"S: I95T; nsp12: F192V","spike_mutations":"I95T"}}},{"name":"AY.6","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7358286380767822}},"branch_attrs":{"mutations":{"nuc":["G2336A","G17331T","T21846C"],"S":["I95T"],"nsp13":["E365D"],"nsp2":["D511N"]},"labels":{"aa":"S: I95T; nsp13: E365D; nsp2: D511N","spike_mutations":"I95T"}}},{"name":"AY.76","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.76"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.76"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.444540977478027}},"branch_attrs":{"mutations":{"nuc":["T7233C","A16775G","T21846C"],"S":["I95T"],"nsp13":["Y180C"],"nsp3":["L1505S"]},"labels":{"aa":"S: I95T; nsp13: Y180C; nsp3: L1505S","spike_mutations":"I95T"}}},{"name":"AY.77","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.77"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:120-122"},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.77"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.144852638244629}},"branch_attrs":{"mutations":{"nuc":["C10376T","T21846C","T27346C","-28250T","-28251T","-28252T","-28253C"],"ORF6":["Y49H"],"S":["I95T"],"nsp5":["P108S"]},"labels":{"aa":"ORF6: Y49H; S: I95T; nsp5: P108S","spike_mutations":"I95T"}}},{"name":"AY.80","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.80"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.80"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.398502349853516}},"branch_attrs":{"mutations":{"nuc":["G5017A","G12479A","C19186T","G19735T","T21846C","G28028T"],"ORF8":["W45C"],"S":["I95T"],"nsp15":["D39Y"],"nsp8":["V130I"]},"labels":{"aa":"ORF8: W45C; S: I95T; nsp15: D39Y; nsp8: V130I","spike_mutations":"I95T"}}},{"name":"AY.81","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.81"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.81"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.495382308959961}},"branch_attrs":{"mutations":{"nuc":["G11358A","T21846C","C23643T","G25340T","A28032G","C28087T","C29530T"],"ORF8":["I47V","A65V"],"S":["I95T","A694V","D1260Y"],"nsp6":["R129K"]},"labels":{"aa":"ORF8: I47V, A65V; S: I95T, A694V, D1260Y; nsp6: R129K","spike_mutations":"I95T, A694V, D1260Y"}}},{"name":"AY.79","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.79"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.79"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.318887233734131}},"branch_attrs":{"mutations":{"nuc":["T2125C","T21846C"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}}},{"name":"AY.82","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.82"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.82"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3766937255859375}},"branch_attrs":{"mutations":{"nuc":["C9144T","T21846C","C22783T"],"S":["I95T"],"nsp4":["S197F"]},"labels":{"aa":"S: I95T; nsp4: S197F","spike_mutations":"I95T"}}},{"name":"AY.84","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.84"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.84"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8311426639556885}},"branch_attrs":{"mutations":{"nuc":["T21846C","C27297T","G28086T"],"ORF8":["A65S"],"S":["I95T"]},"labels":{"aa":"ORF8: A65S; S: I95T","spike_mutations":"I95T"}}},{"name":"AY.83","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.83"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.83"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.158646106719971}},"branch_attrs":{"mutations":{"nuc":["C5544T","G15243T","T21846C","A25491T"],"S":["I95T"],"nsp12":["M601I"],"nsp3":["T942I"]},"labels":{"aa":"S: I95T; nsp12: M601I; nsp3: T942I","spike_mutations":"I95T"}}},{"name":"AY.87","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.87"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.87"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.119286060333252}},"branch_attrs":{"mutations":{"nuc":["C832T","C2091T","C12651T","C17156T","A19815T","T21846C","G27556T"],"ORF7a":["A55S"],"S":["I95T"],"nsp13":["T307I"],"nsp2":["T429I"],"nsp8":["T187I"]},"labels":{"aa":"ORF7a: A55S; S: I95T; nsp13: T307I; nsp2: T429I; nsp8: T187I","spike_mutations":"I95T"}}},{"name":"AY.86","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.86"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.86"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.11639928817749}},"branch_attrs":{"mutations":{"nuc":["G15380T","T21846C","G24095T","C29445T"],"N":["T391I"],"S":["I95T","A845S"],"nsp12":["S647I"]},"labels":{"aa":"N: T391I; S: I95T, A845S; nsp12: S647I","spike_mutations":"I95T, A845S"}}},{"name":"AY.88","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.88"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.88"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.1931376457214355}},"branch_attrs":{"mutations":{"nuc":["G20709T","T21846C","C28724T"],"N":["P151S"],"S":["I95T"],"nsp16":["M17I"]},"labels":{"aa":"N: P151S; S: I95T; nsp16: M17I","spike_mutations":"I95T"}}},{"name":"AY.90","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.90"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.90"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9251A","G11083T","T21846C","C25931T","G26720A","G27990T","T28735C"],"ORF3a":["S180F"],"ORF8":["V33F"],"S":["I95T"],"nsp4":["V233I"],"nsp6":["L37F"]},"labels":{"aa":"ORF3a: S180F; ORF8: V33F; S: I95T; nsp4: V233I; nsp6: L37F","spike_mutations":"I95T"}}},{"name":"AY.94","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.94"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.94"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.735548973083496}},"branch_attrs":{"mutations":{"nuc":["G463A","G6367T","C15924T","G16975T","T21846C","C22987T"],"S":["I95T"],"nsp13":["V247F"],"nsp3":["Q1216H"]},"labels":{"aa":"S: I95T; nsp13: V247F; nsp3: Q1216H","spike_mutations":"I95T"}}},{"name":"AY.92","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.92"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.92"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.508190155029297}},"branch_attrs":{"mutations":{"nuc":["C28657T","C29167T"]}}},{"name":"AY.93","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.93"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.93"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6097846031188965}},"branch_attrs":{"mutations":{"nuc":["A1087G","C1101T","C7262T","T21846C"],"S":["I95T"],"nsp2":["S99F"],"nsp3":["L1515F"]},"labels":{"aa":"S: I95T; nsp2: S99F; nsp3: L1515F","spike_mutations":"I95T"}}},{"name":"NODE_0000544","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.529526472091675}},"branch_attrs":{"mutations":{"nuc":["C9559T","C15240T","T28007C"]}},"children":[{"name":"AY.101","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.101"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.101"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4137604236602783}},"branch_attrs":{"mutations":{"nuc":["C925T","C9474T","C25460T"],"ORF3a":["A23V"],"nsp4":["A307V"]},"labels":{"aa":"ORF3a: A23V; nsp4: A307V"}}},{"name":"AY.100","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.100"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.100"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2730963230133057}},"branch_attrs":{"mutations":{"nuc":["G17122T"],"nsp13":["A296S"]},"labels":{"aa":"nsp13: A296S"}}}]},{"name":"NODE_0000545","node_attrs":{"div":35,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.117180824279785}},"branch_attrs":{"mutations":{"nuc":["A17236G","T21846C"],"S":["I95T"],"nsp13":["I334V"]},"labels":{"aa":"S: I95T; nsp13: I334V","spike_mutations":"I95T"}},"children":[{"name":"AY.103","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.103"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.103"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.7256762981414795}},"branch_attrs":{"mutations":{"nuc":["C24208T"]}}},{"name":"AY.41","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.41"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.41"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3733155727386475}},"branch_attrs":{"mutations":{"nuc":["G1820A","G2272T","G7936T","G9220A","A13712G","C14119T","C18395T","G22346T","G22992T","G25062T","-28271A"],"S":["A262S","S477I","G1167V"],"nsp12":["K91R","P227S"],"nsp14":["A119V"],"nsp2":["G339S","K489N"]},"labels":{"aa":"S: A262S, S477I, G1167V; nsp12: K91R, P227S; nsp14: A119V; nsp2: G339S, K489N","spike_mutations":"A262S, S477I, G1167V"}}}]},{"name":"NODE_0000546","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.208604335784912}},"branch_attrs":{"mutations":{"nuc":["G16914T"]}},"children":[{"name":"AY.114","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.114"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.114"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.435467481613159}},"branch_attrs":{"mutations":{"nuc":["C884T","G19677T"],"nsp15":["Q19H"],"nsp2":["R27C"]},"labels":{"aa":"nsp15: Q19H; nsp2: R27C"}}},{"name":"AY.85","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.85"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.85"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.350363254547119}},"branch_attrs":{"mutations":{"nuc":["A708G","C1825T","T17748A","C25810T","G26428T","C26873T"],"E":["V62F"],"ORF3a":["L140F"],"nsp1":["E148G"]},"labels":{"aa":"E: V62F; ORF3a: L140F; nsp1: E148G"}}}]},{"name":"NODE_0000547","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.116"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.899040699005127}},"branch_attrs":{"mutations":{"nuc":["A10691G"],"nsp5":["I213V"]},"labels":{"aa":"nsp5: I213V"}},"children":[{"name":"AY.116","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.116"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.899040699005127}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.116.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.116.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.500979423522949}},"branch_attrs":{"mutations":{"nuc":["G12071A","C19160T","G20968A"],"nsp14":["S374F"],"nsp16":["V104I"],"nsp7":["D77N"]},"labels":{"aa":"nsp14: S374F; nsp16: V104I; nsp7: D77N"}}}]},{"name":"NODE_0000548","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.121"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.015531301498413}},"branch_attrs":{"mutations":{"nuc":["A1C","C13168T","C23557T","G25996T"],"ORF3a":["V202L"]},"labels":{"aa":"ORF3a: V202L"}},"children":[{"name":"AY.121.1","node_attrs":{"div":46,"Nextclade_pango":{"value":"AY.121.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4786579608917236}},"branch_attrs":{"mutations":{"nuc":["T209C","T6949C","C16726T","C19859T","C21648T","C27638T","C27737T","G28396A","G29690T"],"ORF7a":["A82V","T115I"],"ORF9b":["G38D"],"S":["T29I"],"nsp13":["H164Y"],"nsp15":["A80V"]},"labels":{"aa":"ORF7a: A82V, T115I; ORF9b: G38D; S: T29I; nsp13: H164Y; nsp15: A80V","spike_mutations":"T29I"}}},{"name":"AY.121","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.015531301498413}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000549","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.123"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.456477165222168}},"branch_attrs":{"mutations":{"nuc":["C897T","C5730T","A7519C","C15738T","G17790T","T21846C","C25350T","G27762T"],"ORF7b":["E3*"],"S":["I95T","P1263L"],"nsp13":["Q518H"],"nsp2":["A31V"],"nsp3":["T1004I"]},"labels":{"aa":"ORF7b: E3*; S: I95T, P1263L; nsp13: Q518H; nsp2: A31V; nsp3: T1004I","spike_mutations":"I95T, P1263L"}},"children":[{"name":"AY.123","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.456477165222168}},"branch_attrs":{"mutations":{}}},{"name":"AY.123.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.123.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.658041954040527}},"branch_attrs":{"mutations":{"nuc":["G20002T","A24410G"],"S":["N950D"],"nsp15":["D128Y"]},"labels":{"aa":"S: N950D; nsp15: D128Y","spike_mutations":"N950D"}}}]},{"name":"NODE_0000550","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.127"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1094322204589844}},"branch_attrs":{"mutations":{"nuc":["A1T","G25538T","C26054A"],"ORF3a":["G49V","T221K"]},"labels":{"aa":"ORF3a: G49V, T221K"}},"children":[{"name":"AY.127","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.127"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1094322204589844}},"branch_attrs":{"mutations":{}}},{"name":"AY.127.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.127.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6556131839752197}},"branch_attrs":{"mutations":{"nuc":["G242A","T7816C","A19445G","G23608T","C24138A","G28378T"],"ORF9b":["R32L"],"S":["T859N"],"nsp14":["K469R"]},"labels":{"aa":"ORF9b: R32L; S: T859N; nsp14: K469R","spike_mutations":"T859N"}}}]},{"name":"NODE_0000551","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.23"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3406074047088623}},"branch_attrs":{"mutations":{"nuc":["C1404T","C4752T","T21846C","G25352T"],"S":["I95T","V1264L"],"nsp2":["P200L"],"nsp3":["T678I"]},"labels":{"aa":"S: I95T, V1264L; nsp2: P200L; nsp3: T678I","spike_mutations":"I95T, V1264L"}},"children":[{"name":"AY.23","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3406074047088623}},"branch_attrs":{"mutations":{}}},{"name":"AY.23.1","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4683518409729004}},"branch_attrs":{"mutations":{"nuc":["C1263T","C5497T","A7537G","C12100T","A14748G","G17679T","T22213C","C25262A"],"S":["L1234I"],"nsp2":["T153M"]},"labels":{"aa":"S: L1234I; nsp2: T153M","spike_mutations":"L1234I"}}}]},{"name":"NODE_0000552","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.29"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5792689323425293}},"branch_attrs":{"mutations":{"nuc":["A1G","C5239T","T5514C"],"nsp3":["V932A"]},"labels":{"aa":"nsp3: V932A"}},"children":[{"name":"AY.29","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5792689323425293}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.29.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.29.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.489469528198242}},"branch_attrs":{"mutations":{"nuc":["G22081T"],"S":["Q173H"]},"labels":{"aa":"S: Q173H","spike_mutations":"Q173H"}}}]},{"name":"NODE_0000553","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.512903690338135}},"branch_attrs":{"mutations":{"nuc":["T21846C","C23277T","G24124A","-28271A"],"S":["I95T","T572I"]},"labels":{"aa":"S: I95T, T572I","spike_mutations":"I95T, T572I"}},"children":[{"name":"AY.32","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.32"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.96708345413208}},"branch_attrs":{"mutations":{"nuc":["C9286T","C21304T"],"nsp16":["R216C"]},"labels":{"aa":"nsp16: R216C"}}},{"name":"AY.95","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.95"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.95"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.070797920227051}},"branch_attrs":{"mutations":{"nuc":["T22293C"],"S":["L244S"]},"labels":{"aa":"S: L244S","spike_mutations":"L244S"}}}]},{"name":"NODE_0000554","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.33"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1432621479034424}},"branch_attrs":{"mutations":{"nuc":["A21647G","T21846C","C22311T"],"S":["T29A","I95T","T250I"]},"labels":{"aa":"S: T29A, I95T, T250I","spike_mutations":"T29A, I95T, T250I"}},"children":[{"name":"AY.33","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.33"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1432621479034424}},"branch_attrs":{"mutations":{}}},{"name":"AY.33.1","node_attrs":{"div":47,"Nextclade_pango":{"value":"AY.33.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":26},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:77-122"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C4182T","T10190C","A11111G","C14318T","C17439T","A18887G","G21010T","C21707T","C22458T","G23401T","G23522A","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-"],"S":["H49Y","T299I","Q613H","E654K"],"nsp12":["T293I"],"nsp14":["H283R"],"nsp16":["V118L"],"nsp3":["S488F"],"nsp5":["S46P"],"nsp6":["M47V"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-; S: H49Y, T299I, Q613H, E654K; nsp12: T293I; nsp14: H283R; nsp16: V118L; nsp3: S488F; nsp5: S46P; nsp6: M47V","spike_mutations":"H49Y, T299I, Q613H, E654K"}}}]},{"name":"NODE_0000555","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.42"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0401339530944824}},"branch_attrs":{"mutations":{"nuc":["G2258A","C12073T","C15237T","C25872T"],"nsp2":["V485I"]},"labels":{"aa":"nsp2: V485I"}},"children":[{"name":"AY.42","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.42"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0401339530944824}},"branch_attrs":{"mutations":{}}},{"name":"AY.42.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.734266996383667}},"branch_attrs":{"mutations":{"nuc":["T4081A","C23718T","C24374T"],"S":["T719I","L938F"],"nsp3":["S454R"]},"labels":{"aa":"S: T719I, L938F; nsp3: S454R","spike_mutations":"T719I, L938F"}}}]},{"name":"NODE_0000556","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.98"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.87161922454834}},"branch_attrs":{"mutations":{"nuc":["G526T","C19524T","T21846C"],"S":["I95T"],"nsp1":["E87D"]},"labels":{"aa":"S: I95T; nsp1: E87D","spike_mutations":"I95T"}},"children":[{"name":"AY.98","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.98"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.87161922454834}},"branch_attrs":{"mutations":{}}},{"name":"AY.98.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.98.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.623765707015991}},"branch_attrs":{"mutations":{"nuc":["G2518T","G5437T","C7768T","C22314T","G28086T"],"ORF8":["A65S"],"S":["P251L"],"nsp3":["E906D"]},"labels":{"aa":"ORF8: A65S; S: P251L; nsp3: E906D","spike_mutations":"P251L"}}}]},{"name":"NODE_0000557","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.102"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.505928039550781}},"branch_attrs":{"mutations":{"nuc":["G1495T","G11083T","A27690T","C29836T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"AY.102","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.505928039550781}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000558","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.102"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.112253189086914}},"branch_attrs":{"mutations":{"nuc":["A21987G","T25333C","A29700G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.102.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.102.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-5.035328388214111}},"branch_attrs":{"mutations":{"nuc":["G25218T"],"S":["G1219V"]},"labels":{"aa":"S: G1219V","spike_mutations":"G1219V"}}},{"name":"AY.102.2","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.102.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.796263694763184}},"branch_attrs":{"mutations":{"nuc":["C26395A","G29861T","G29862A","T29867-"],"E":["L51I"]},"labels":{"aa":"E: L51I"}}}]}]},{"name":"NODE_0000559","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8980414867401123}},"branch_attrs":{"mutations":{"nuc":["C745T"]}},"children":[{"name":"AY.104","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.104"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.104"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.190604209899902}},"branch_attrs":{"mutations":{"nuc":["T13048C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"AY.108","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.108"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.108"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.212310314178467}},"branch_attrs":{"mutations":{"nuc":["T2C","G370T","C823T","C6828T"],"nsp3":["S1370F"]},"labels":{"aa":"nsp3: S1370F"}}},{"name":"AY.125","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.125"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.125"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7532522678375244}},"branch_attrs":{"mutations":{"nuc":["C6730T","C13944T","G15906T","G18905A","G25471T","A26786G"],"ORF3a":["D27Y"],"nsp12":["Q822H"],"nsp14":["R289H"]},"labels":{"aa":"ORF3a: D27Y; nsp12: Q822H; nsp14: R289H"}}}]},{"name":"NODE_0000560","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5868980884552}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"AY.113","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.113"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.113"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0679993629455566}},"branch_attrs":{"mutations":{"nuc":["A1G","C9165T","A12772G","C15240T"],"nsp4":["T204I"]},"labels":{"aa":"nsp4: T204I"}}},{"name":"NODE_0000561","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.124"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5670838356018066}},"branch_attrs":{"mutations":{"nuc":["C1593T","C21301A"],"nsp16":["P215T"],"nsp2":["S263F"]},"labels":{"aa":"nsp16: P215T; nsp2: S263F"}},"children":[{"name":"AY.124","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.124"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5670838356018066}},"branch_attrs":{"mutations":{}}},{"name":"AY.124.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.124.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":35},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.139280796051025}},"branch_attrs":{"mutations":{"nuc":["C4276T","G25445T","G25720T","C26058T","G28628T"],"N":["A119S"],"ORF3a":["G18V","A110S"]},"labels":{"aa":"N: A119S; ORF3a: G18V, A110S"}}}]}]},{"name":"NODE_0000562","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.119"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9526422023773193}},"branch_attrs":{"mutations":{"nuc":["C8829T","G19006T"],"nsp14":["A323S"],"nsp4":["A92V"]},"labels":{"aa":"nsp14: A323S; nsp4: A92V"}},"children":[{"name":"AY.119","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.119"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9526422023773193}},"branch_attrs":{"mutations":{}}},{"name":"AY.119.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.119.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":38},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.377318382263184}},"branch_attrs":{"mutations":{"nuc":["C100T","C2973T","G17338T","C22227T","T24063C","G25552T","G26031T","T26621C","G29392T"],"N":["K373N"],"ORF3a":["A54S","Q213H"],"S":["A222V","I834T"],"nsp13":["A368S"],"nsp3":["A85V"]},"labels":{"aa":"N: K373N; ORF3a: A54S, Q213H; S: A222V, I834T; nsp13: A368S; nsp3: A85V","spike_mutations":"A222V, I834T"}}},{"name":"AY.119.2","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.119.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.131967067718506}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000563","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.25"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.314873695373535}},"branch_attrs":{"mutations":{"nuc":["A1G","T21846C","G26107C","A27507C"],"ORF3a":["E239Q"],"S":["I95T"]},"labels":{"aa":"ORF3a: E239Q; S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.25","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.25"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.314873695373535}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000564","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.25.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.4324440956115723}},"branch_attrs":{"mutations":{"nuc":["A3948G","G11562T"],"nsp3":["D410G"],"nsp6":["C197F"]},"labels":{"aa":"nsp3: D410G; nsp6: C197F"}},"children":[{"name":"AY.25.1.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.25.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.2396397590637207}},"branch_attrs":{"mutations":{"nuc":["G2564A","A21987G","G23948T"],"S":["D142G","D796Y"],"nsp2":["E587K"]},"labels":{"aa":"S: D142G, D796Y; nsp2: E587K","spike_mutations":"D142G, D796Y"}}},{"name":"AY.25.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.4324440956115723}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000565","node_attrs":{"div":35,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.468881368637085}},"branch_attrs":{"mutations":{"nuc":["T21846C","C25413T","-28271A"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.45","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.45"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.45"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.299954891204834}},"branch_attrs":{"mutations":{"nuc":["G13812T"],"nsp12":["M124I"]},"labels":{"aa":"nsp12: M124I"}}},{"name":"NODE_0000566","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.91"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.198517322540283}},"branch_attrs":{"mutations":{"nuc":["T1871C","C28236T","G29744A"],"ORF8":["R115C"],"nsp2":["F356L"]},"labels":{"aa":"ORF8: R115C; nsp2: F356L"}},"children":[{"name":"AY.91","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.91"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.198517322540283}},"branch_attrs":{"mutations":{}}},{"name":"AY.91.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.91.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.921102523803711}},"branch_attrs":{"mutations":{"nuc":["C15540T","C17010T","G25650T","A28271-","C28310T"],"N":["P13S"],"ORF3a":["L86F"]},"labels":{"aa":"N: P13S; ORF3a: L86F"}}}]}]},{"name":"NODE_0000567","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.7"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8977537155151367}},"branch_attrs":{"mutations":{"nuc":["T2C","G2944A","G11365T","G12718T","T21846C","G27566T","C27629A"],"ORF7a":["C58F","A79D"],"S":["I95T"],"nsp9":["Q11H"]},"labels":{"aa":"ORF7a: C58F, A79D; S: I95T; nsp9: Q11H","spike_mutations":"I95T"}},"children":[{"name":"AY.7.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1598989963531494}},"branch_attrs":{"mutations":{"nuc":["T15882G","A18675G"]}}},{"name":"AY.7","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8977537155151367}},"branch_attrs":{"mutations":{}}},{"name":"AY.7.2","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.7634453773498535}},"branch_attrs":{"mutations":{"nuc":["C2T","G25445T"],"ORF3a":["G18V"]},"labels":{"aa":"ORF3a: G18V"}}}]},{"name":"NODE_0000568","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.99"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.52271842956543}},"branch_attrs":{"mutations":{"nuc":["A3536G","T13216C","C15240T","T21846C"],"S":["I95T"],"nsp3":["I273V"]},"labels":{"aa":"S: I95T; nsp3: I273V","spike_mutations":"I95T"}},"children":[{"name":"AY.99","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.99"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.52271842956543}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000569","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.99"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.392517566680908}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.99.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.99.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.140461444854736}},"branch_attrs":{"mutations":{"nuc":["C8994T"],"nsp4":["T147I"]},"labels":{"aa":"nsp4: T147I"}}},{"name":"AY.99.2","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.99.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7914319038391113}},"branch_attrs":{"mutations":{"nuc":["C4927T","A5638G","C12525T"],"nsp8":["T145I"]},"labels":{"aa":"nsp8: T145I"}}}]}]},{"name":"NODE_0000570","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.120"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.007944345474243}},"branch_attrs":{"mutations":{"nuc":["C6408T","A25003G"],"nsp3":["S1230F"]},"labels":{"aa":"nsp3: S1230F"}},"children":[{"name":"AY.120","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.120"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.007944345474243}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.120.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.541743040084839}},"branch_attrs":{"mutations":{"nuc":["C11095T"]}}},{"name":"NODE_0000571","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.120.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.589193820953369}},"branch_attrs":{"mutations":{"nuc":["G174T","C21758T"],"S":["H66Y"]},"labels":{"aa":"S: H66Y","spike_mutations":"H66Y"}},"children":[{"name":"AY.120.2","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.120.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.589193820953369}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.2.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.120.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.859754800796509}},"branch_attrs":{"mutations":{"nuc":["C7105T","C13138T","T27017A"]}}}]}]},{"name":"NODE_0000572","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.122"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.137082099914551}},"branch_attrs":{"mutations":{"nuc":["G1048T","T21846C"],"S":["I95T"],"nsp2":["K81N"]},"labels":{"aa":"S: I95T; nsp2: K81N","spike_mutations":"I95T"}},"children":[{"name":"AY.122.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.122.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.737865447998047}},"branch_attrs":{"mutations":{"nuc":["G13892A","G14772A","G22793T"],"S":["A411S"],"nsp12":["C151Y"]},"labels":{"aa":"S: A411S; nsp12: C151Y","spike_mutations":"A411S"}}},{"name":"AY.122","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.122"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.137082099914551}},"branch_attrs":{"mutations":{}}},{"name":"AY.122.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.122.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.565906286239624}},"branch_attrs":{"mutations":{"nuc":["C19983T","G20937T","C23934T","C25516T"],"ORF3a":["P42S"],"S":["T791I"]},"labels":{"aa":"ORF3a: P42S; S: T791I","spike_mutations":"T791I"}}},{"name":"AY.122.3","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.122.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.337819576263428}},"branch_attrs":{"mutations":{"nuc":["T168C","C12513T","G17338A","T17694C","T20838C","G23401T","C27527T","C28873A"],"ORF7a":["P45L"],"S":["Q613H"],"nsp13":["A368T"],"nsp8":["T141M"]},"labels":{"aa":"ORF7a: P45L; S: Q613H; nsp13: A368T; nsp8: T141M","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000573","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3768041133880615}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"AY.22","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.22"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.22"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3188090324401855}},"branch_attrs":{"mutations":{"nuc":["G11083T","T12496C","G14209T","A21987G","G22216T","G26062T"],"ORF3a":["G224C"],"S":["D142G","Q218H"],"nsp12":["V257F"],"nsp6":["L37F"]},"labels":{"aa":"ORF3a: G224C; S: D142G, Q218H; nsp12: V257F; nsp6: L37F","spike_mutations":"D142G, Q218H"}}},{"name":"AY.36","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.36"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9737911224365234}},"branch_attrs":{"mutations":{"nuc":["T15628C","G18079T","A20532G","C29738T"],"nsp12":["C730R"],"nsp14":["V14L"]},"labels":{"aa":"nsp12: C730R; nsp14: V14L"}}},{"name":"NODE_0000574","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.20"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.005821704864502}},"branch_attrs":{"mutations":{"nuc":["C2061T"],"nsp2":["A419V"]},"labels":{"aa":"nsp2: A419V"}},"children":[{"name":"AY.20","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.20"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.005821704864502}},"branch_attrs":{"mutations":{}}},{"name":"AY.20.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.686790943145752}},"branch_attrs":{"mutations":{"nuc":["C8880T","G9190T","C11173T","C24106T","G25481T","C27393T","G29737T"],"ORF3a":["R30L"],"nsp4":["T109M"]},"labels":{"aa":"ORF3a: R30L; nsp4: T109M"}}}]}]},{"name":"NODE_0000575","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.3"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6765198707580566}},"branch_attrs":{"mutations":{"nuc":["T3C","A11456G","T21846C","G29050A","C29509T"],"S":["I95T"],"nsp6":["I162V"]},"labels":{"aa":"S: I95T; nsp6: I162V","spike_mutations":"I95T"}},"children":[{"name":"AY.3","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6765198707580566}},"branch_attrs":{"mutations":{}}},{"name":"AY.3.2","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8443009853363037}},"branch_attrs":{"mutations":{"nuc":["G5155A","C5784T","A10075G","A21987G","C22338T","C29546T","C29750T"],"S":["D142G","T259I"],"nsp3":["T1022I"]},"labels":{"aa":"S: D142G, T259I; nsp3: T1022I","spike_mutations":"D142G, T259I"}}},{"name":"NODE_0000576","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.3"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2108216285705566}},"branch_attrs":{"mutations":{"nuc":["T23284C","C25339T"]}},"children":[{"name":"AY.3.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9937119483947754}},"branch_attrs":{"mutations":{"nuc":["G3644T","C18115T","C20199T","A21987G"],"S":["D142G"],"nsp14":["H26Y"],"nsp3":["D309Y"]},"labels":{"aa":"S: D142G; nsp14: H26Y; nsp3: D309Y","spike_mutations":"D142G"}}},{"name":"AY.3.3","node_attrs":{"div":47,"Nextclade_pango":{"value":"AY.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.715099334716797}},"branch_attrs":{"mutations":{"nuc":["T2083C","A6229G","C9924T","T12538C","G21770A","A22803G","A26021C"],"ORF3a":["D210A"],"S":["V70I","Q414R"],"nsp4":["A457V"]},"labels":{"aa":"ORF3a: D210A; S: V70I, Q414R; nsp4: A457V","spike_mutations":"V70I, Q414R"}}}]}]},{"name":"NODE_0000577","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.34"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4385077953338623}},"branch_attrs":{"mutations":{"nuc":["A1G","G9441T","G18255T","C22498T","G23593C","G26109A","C26681T","G27014T"],"S":["Q677H"],"nsp14":["M72I"],"nsp4":["C296F"]},"labels":{"aa":"S: Q677H; nsp14: M72I; nsp4: C296F","spike_mutations":"Q677H"}},"children":[{"name":"AY.34","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.34"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4385077953338623}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.2","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.34.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":35},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6427252292633057}},"branch_attrs":{"mutations":{"nuc":["G11417T","A14457G","C21110T","C24138T"],"S":["T859I"],"nsp16":["T151I"],"nsp6":["V149F"]},"labels":{"aa":"S: T859I; nsp16: T151I; nsp6: V149F","spike_mutations":"T859I"}}},{"name":"NODE_0000578","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.34.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.636735677719116}},"branch_attrs":{"mutations":{"nuc":["C25355T","C28961T"],"N":["L230F"],"S":["L1265F"]},"labels":{"aa":"N: L230F; S: L1265F","spike_mutations":"L1265F"}},"children":[{"name":"AY.34.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.636735677719116}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.1.1","node_attrs":{"div":46,"Nextclade_pango":{"value":"AY.34.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8207154273986816}},"branch_attrs":{"mutations":{"nuc":["C2106T","G8017T","A21987G"],"S":["D142G"],"nsp2":["T434I"]},"labels":{"aa":"S: D142G; nsp2: T434I","spike_mutations":"D142G"}}}]}]},{"name":"NODE_0000579","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.39"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.785830497741699}},"branch_attrs":{"mutations":{"nuc":["G21372T","G27604A"],"ORF7a":["V71I"],"nsp16":["Q238H"]},"labels":{"aa":"ORF7a: V71I; nsp16: Q238H"}},"children":[{"name":"AY.39","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.785830497741699}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.2","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.39.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.734314203262329}},"branch_attrs":{"mutations":{"nuc":["G2494T","G5716T","C6883T","A21987G","G24781C"],"S":["D142G","K1073N"],"nsp2":["E563D"],"nsp3":["K999N"]},"labels":{"aa":"S: D142G, K1073N; nsp2: E563D; nsp3: K999N","spike_mutations":"D142G, K1073N"}}},{"name":"NODE_0000580","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.39.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0565383434295654}},"branch_attrs":{"mutations":{"nuc":["A13482G"]}},"children":[{"name":"AY.39.1.2","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.39.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:78-122"},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.295746326446533}},"branch_attrs":{"mutations":{"nuc":["G1577A","C18555T","C25568T","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF3a":["A59V"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"nsp2":["V258I"]},"labels":{"aa":"ORF3a: A59V; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; nsp2: V258I"}}},{"name":"AY.39.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0565383434295654}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.1.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.39.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3922364711761475}},"branch_attrs":{"mutations":{"nuc":["G19563T"],"nsp14":["L508F"]},"labels":{"aa":"nsp14: L508F"}}},{"name":"AY.39.1.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.39.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:78-122"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9028074741363525}},"branch_attrs":{"mutations":{"nuc":["G2164T","A21987G","C25046G","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"S":["D142G","P1162A"],"nsp2":["E453D"]},"labels":{"aa":"ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; S: D142G, P1162A; nsp2: E453D","spike_mutations":"D142G, P1162A"}}}]}]},{"name":"NODE_0000581","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.5"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3081870079040527}},"branch_attrs":{"mutations":{"nuc":["T21846C","G24928T"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.5","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3081870079040527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000582","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.5"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.431300640106201}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}},"children":[{"name":"AY.5.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.416350364685059}},"branch_attrs":{"mutations":{"nuc":["C12369T","C25572T"],"nsp8":["T93I"]},"labels":{"aa":"nsp8: T93I"}}},{"name":"AY.5.3","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8519368171691895}},"branch_attrs":{"mutations":{"nuc":["C7488T"],"nsp3":["T1590I"]},"labels":{"aa":"nsp3: T1590I"}}},{"name":"AY.5.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.63433313369751}},"branch_attrs":{"mutations":{"nuc":["C27143A"],"M":["N207K"]},"labels":{"aa":"M: N207K"}}},{"name":"AY.5.4","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.515988826751709}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"nsp2":["P129L"]},"labels":{"aa":"nsp2: P129L"}}},{"name":"AY.5.5","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C6840T","G17193T","T23398C"],"nsp13":["E319D"],"nsp3":["A1374V"]},"labels":{"aa":"nsp13: E319D; nsp3: A1374V"}}}]}]},{"name":"NODE_0000583","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.4"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.6842306852340698}},"branch_attrs":{"mutations":{"nuc":["C7851T","T17040C"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}},"children":[{"name":"AY.4.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.036841869354248}},"branch_attrs":{"mutations":{"nuc":["C2706T","T18927C","A20374C","G22899T"],"S":["G446V"],"nsp15":["I252L"],"nsp2":["T634I"]},"labels":{"aa":"S: G446V; nsp15: I252L; nsp2: T634I","spike_mutations":"G446V"}}},{"name":"AY.4.6","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1065313816070557}},"branch_attrs":{"mutations":{"nuc":["C16293T","C19524T","C20404T","A28967G"],"N":["S232G"],"nsp15":["P262S"]},"labels":{"aa":"N: S232G; nsp15: P262S"}}},{"name":"AY.4.9","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.9"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8668172359466553}},"branch_attrs":{"mutations":{"nuc":["C3140T","T4066A","C12513T"],"nsp3":["P141S"],"nsp8":["T141M"]},"labels":{"aa":"nsp3: P141S; nsp8: T141M"}}},{"name":"NODE_0000584","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5732269287109375}},"branch_attrs":{"mutations":{"nuc":["T21995C","C22227T","C25614T"],"S":["Y145H","A222V"]},"labels":{"aa":"S: Y145H, A222V","spike_mutations":"Y145H, A222V"}},"children":[{"name":"AY.4.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5732269287109375}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.2.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.4.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.891268253326416}},"branch_attrs":{"mutations":{"nuc":["C15720T","C18687T","G21668T","G28878T"],"N":["S202I"],"S":["V36F"]},"labels":{"aa":"N: S202I; S: V36F","spike_mutations":"V36F"}}},{"name":"AY.4.2.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4512696266174316}},"branch_attrs":{"mutations":{"nuc":["G26526T"],"M":["A2S"]},"labels":{"aa":"M: A2S"}}},{"name":"AY.4.2.2","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7742323875427246}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.46"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.140479564666748}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T","T21846C"],"S":["I95T"],"nsp6":["A2V"]},"labels":{"aa":"S: I95T; nsp6: A2V","spike_mutations":"I95T"}},"children":[{"name":"AY.46.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9886834621429443}},"branch_attrs":{"mutations":{"nuc":["T25673C"],"ORF3a":["L94P"]},"labels":{"aa":"ORF3a: L94P"}}},{"name":"AY.46.2","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8988404273986816}},"branch_attrs":{"mutations":{"nuc":["A17799G","-28271A"]}}},{"name":"AY.46","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.46"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.140479564666748}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.46.3","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.46.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["G11083T","G14186T","C19637T","A21987G","G28378T"],"ORF9b":["R32L"],"S":["D142G"],"nsp12":["R249M"],"nsp15":["A6V"],"nsp6":["L37F"]},"labels":{"aa":"ORF9b: R32L; S: D142G; nsp12: R249M; nsp15: A6V; nsp6: L37F","spike_mutations":"D142G"}}},{"name":"AY.46.5","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.46.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0682404041290283}},"branch_attrs":{"mutations":{"nuc":["C15569T","T16242G"],"nsp12":["T710I"]},"labels":{"aa":"nsp12: T710I"}}},{"name":"AY.46.4","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3499815464019775}},"branch_attrs":{"mutations":{"nuc":["G23545T"],"S":["E661D"]},"labels":{"aa":"S: E661D","spike_mutations":"E661D"}}},{"name":"AY.46.6","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.46.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.8154752254486084}},"branch_attrs":{"mutations":{"nuc":["C6310T","C8326T"]}}}]},{"name":"NODE_0000586","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.29671049118042}},"branch_attrs":{"mutations":{"nuc":["C15952A","T21846C","A28299T"],"N":["Q9L"],"ORF9b":["S6C"],"S":["I95T"],"nsp12":["L838I"]},"labels":{"aa":"N: Q9L; ORF9b: S6C; S: I95T; nsp12: L838I","spike_mutations":"I95T"}},"children":[{"name":"AY.43","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.43"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.29671049118042}},"branch_attrs":{"mutations":{}}},{"name":"AY.43.5","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.43.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["A17457G","A23064G","C23638T","C24937T","C28045T","G28857T","G29179T"],"N":["R195I"],"ORF8":["A51V"],"S":["N501S"]},"labels":{"aa":"N: R195I; ORF8: A51V; S: N501S","spike_mutations":"N501S"}}},{"name":"NODE_0000587","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2766566276550293}},"branch_attrs":{"mutations":{"nuc":["C18744T","C24130T"]}},"children":[{"name":"AY.43.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8277058601379395}},"branch_attrs":{"mutations":{"nuc":["C19955T"],"nsp15":["T112I"]},"labels":{"aa":"nsp15: T112I"}}},{"name":"AY.43.4","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.7761340141296387}},"branch_attrs":{"mutations":{"nuc":["C5241T"],"nsp3":["P841L"]},"labels":{"aa":"nsp3: P841L"}}},{"name":"AY.43.6","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.43.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3442533016204834}},"branch_attrs":{"mutations":{"nuc":["C233T","C1952A","T27409C","G29081T"],"N":["V270L"],"ORF7a":["F6L"],"nsp2":["Q383K"]},"labels":{"aa":"N: V270L; ORF7a: F6L; nsp2: Q383K"}}},{"name":"NODE_0000588","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.3868703842163086}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.43.2","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.43.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.030745029449463}},"branch_attrs":{"mutations":{"nuc":["G3728T"],"nsp3":["G337C"]},"labels":{"aa":"nsp3: G337C"}}},{"name":"AY.43.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.167747497558594}},"branch_attrs":{"mutations":{"nuc":["C12663T","C25433T"],"ORF3a":["T14I"],"nsp8":["A191V"]},"labels":{"aa":"ORF3a: T14I; nsp8: A191V"}}},{"name":"AY.43.7","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.43.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.19292688369751}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}}}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000589","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{"nuc":["G28881A","G28882A","G28883C"],"N":["R203K","G204R"]},"labels":{"aa":"N: R203K, G204R","clade":"20B"}},"children":[{"name":"B.1.1","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.111","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.111"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.111"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.088438510894775}},"branch_attrs":{"mutations":{"nuc":["T27447C","T29661C"],"ORF10":["F35S"]},"labels":{"aa":"ORF10: F35S"}}},{"name":"B.1.1.117","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.117"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.117"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.576686382293701}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"B.1.1.101","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.101"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.101"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.798060417175293}},"branch_attrs":{"mutations":{"nuc":["G8371T","G29868A"],"nsp3":["Q1884H"]},"labels":{"aa":"nsp3: Q1884H"}}},{"name":"B.1.1.115","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.115"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.115"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.550750732421875}},"branch_attrs":{"mutations":{"nuc":["G26918T","T29464C"]}}},{"name":"B.1.1.121","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.121"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.121"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.167267799377441}},"branch_attrs":{"mutations":{"nuc":["C27538T"]}}},{"name":"B.1.1.133","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.133"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.133"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4965T","A8072G","A16011G","A21213G"],"nsp3":["T749I","N1785D"]},"labels":{"aa":"nsp3: T749I, N1785D"}}},{"name":"B.1.1.141","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.141"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.141"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.266036510467529}},"branch_attrs":{"mutations":{"nuc":["T22020C","G26056T"],"ORF3a":["D222Y"],"S":["M153T"]},"labels":{"aa":"ORF3a: D222Y; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.135","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.135"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.135"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.479883193969727}},"branch_attrs":{"mutations":{"nuc":["C10376T"],"nsp5":["P108S"]},"labels":{"aa":"nsp5: P108S"}}},{"name":"B.1.1.161","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.161"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.161"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.094921588897705}},"branch_attrs":{"mutations":{"nuc":["G23403A"],"S":["G614D"]},"labels":{"aa":"S: G614D","spike_mutations":"G614D"}}},{"name":"B.1.1.163","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.163"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.163"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.996835231781006}},"branch_attrs":{"mutations":{"nuc":["G11029A","C21772T","C29518T"]}}},{"name":"B.1.1.157","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.157"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.157"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.1433210372924805}},"branch_attrs":{"mutations":{"nuc":["C6145T","G11272A","C17678T"],"nsp13":["T481M"],"nsp6":["M100I"]},"labels":{"aa":"nsp13: T481M; nsp6: M100I"}}},{"name":"B.1.1.176","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.176"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.176"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8188023567199707}},"branch_attrs":{"mutations":{"nuc":["C8208T","G9267A","T9667C","G25947T","G28361A"],"N":["G30R"],"ORF3a":["Q185H"],"ORF9b":["M26I"],"nsp3":["T1830I"],"nsp4":["S238N"]},"labels":{"aa":"N: G30R; ORF3a: Q185H; ORF9b: M26I; nsp3: T1830I; nsp4: S238N"}}},{"name":"B.1.1.171","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.171"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.171"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.768898010253906}},"branch_attrs":{"mutations":{"nuc":["C1437T","G29745T"],"nsp2":["S211F"]},"labels":{"aa":"nsp2: S211F"}}},{"name":"B.1.1.186","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.186"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.186"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.552818775177002}},"branch_attrs":{"mutations":{"nuc":["C4113T","G21974C","C23191T"],"S":["D138H"],"nsp3":["A465V"]},"labels":{"aa":"S: D138H; nsp3: A465V","spike_mutations":"D138H"}}},{"name":"B.1.1.174","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.174"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.174"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.572410583496094}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.1.189","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.189"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.189"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.426564693450928}},"branch_attrs":{"mutations":{"nuc":["C9430T","C12823T"]}}},{"name":"B.1.1.192","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.192"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.192"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.360202312469482}},"branch_attrs":{"mutations":{"nuc":["A1G","C673T"]}}},{"name":"B.1.1.203","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.203"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.203"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.988719463348389}},"branch_attrs":{"mutations":{"nuc":["C23854T"]}}},{"name":"B.1.1.205","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.205"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.205"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.790339946746826}},"branch_attrs":{"mutations":{"nuc":["G5539A","G21468A"],"nsp16":["M270I"]},"labels":{"aa":"nsp16: M270I"}}},{"name":"B.1.1.198","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.198"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.198"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.466243743896484}},"branch_attrs":{"mutations":{"nuc":["C3261T","A15984T","C20946T"],"nsp3":["T181I"]},"labels":{"aa":"nsp3: T181I"}}},{"name":"B.1.1.207","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.207"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.207"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.1433210372924805}},"branch_attrs":{"mutations":{"nuc":["T9172C","A10948G","C10977T","C23604A","A24874G","G26730T","A26927G"],"M":["V70F"],"S":["P681H"],"nsp6":["A2V"]},"labels":{"aa":"M: V70F; S: P681H; nsp6: A2V","spike_mutations":"P681H"}}},{"name":"B.1.1.231","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.231"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.231"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.254888534545898}},"branch_attrs":{"mutations":{"nuc":["A1G","A25505C"],"ORF3a":["Q38P"]},"labels":{"aa":"ORF3a: Q38P"}}},{"name":"B.1.1.232","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.232"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.232"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.283545970916748}},"branch_attrs":{"mutations":{"nuc":["T2537G","G12191T","T16479C"],"nsp2":["L578V"],"nsp8":["V34F"]},"labels":{"aa":"nsp2: L578V; nsp8: V34F"}}},{"name":"B.1.1.241","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.241"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.241"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.24725866317749}},"branch_attrs":{"mutations":{"nuc":["A11782G","T21570G","C21575T","T25473C","C28253T"],"S":["V3G","L5F"]},"labels":{"aa":"S: V3G, L5F","spike_mutations":"V3G, L5F"}}},{"name":"B.1.1.243","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.243"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.243"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.795328617095947}},"branch_attrs":{"mutations":{"nuc":["C5339T","A9900C","C12733A"],"nsp3":["P874S"],"nsp4":["N449T"]},"labels":{"aa":"nsp3: P874S; nsp4: N449T"}}},{"name":"B.1.1.228","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.228"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.228"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.376809597015381}},"branch_attrs":{"mutations":{"nuc":["A20288G","C21721T","C26894T","C28638A"],"N":["P122H"],"nsp15":["E223G"]},"labels":{"aa":"N: P122H; nsp15: E223G"}}},{"name":"B.1.1.253","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.253"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.253"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.5802154541015625}},"branch_attrs":{"mutations":{"nuc":["T19893C"]}}},{"name":"B.1.1.263","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.263"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.263"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.347754001617432}},"branch_attrs":{"mutations":{"nuc":["G5924A","T21775G"],"nsp3":["V1069I"]},"labels":{"aa":"nsp3: V1069I"}}},{"name":"B.1.1.265","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.265"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.265"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.463467121124268}},"branch_attrs":{"mutations":{"nuc":["C11005A","A28624T"],"nsp6":["H11Q"]},"labels":{"aa":"nsp6: H11Q"}}},{"name":"B.1.1.269","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.269"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.269"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.337708950042725}},"branch_attrs":{"mutations":{"nuc":["C5055T","G11851T","G24812T","C26895T"],"M":["H125Y"],"S":["D1084Y"],"nsp3":["T779I"],"nsp7":["M3I"]},"labels":{"aa":"M: H125Y; S: D1084Y; nsp3: T779I; nsp7: M3I","spike_mutations":"D1084Y"}}},{"name":"B.1.1.274","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.274"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.274"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.456281661987305}},"branch_attrs":{"mutations":{"nuc":["G25912T"],"ORF3a":["G174C"]},"labels":{"aa":"ORF3a: G174C"}}},{"name":"B.1.1.277","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.277"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.277"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.125593185424805}},"branch_attrs":{"mutations":{"nuc":["A1G","T772C","A2869G","C10868T","G15652T","C29095T"],"nsp12":["D738Y"]},"labels":{"aa":"nsp12: D738Y"}}},{"name":"B.1.1.294","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.294"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.294"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.174777507781982}},"branch_attrs":{"mutations":{"nuc":["C3373A","C6883T","G21724A"],"nsp3":["D218E"]},"labels":{"aa":"nsp3: D218E"}}},{"name":"B.1.1.297","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.297"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.297"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4372172355651855}},"branch_attrs":{"mutations":{"nuc":["A20742C","T27922C"],"ORF8":["I10T"],"nsp16":["Q28H"]},"labels":{"aa":"ORF8: I10T; nsp16: Q28H"}}},{"name":"B.1.1.298","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.298"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.298"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.08450984954834}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22920T","C25936T"],"ORF3a":["H182Y"],"S":["Y453F"],"nsp12":["T739I"]},"labels":{"aa":"ORF3a: H182Y; S: Y453F; nsp12: T739I","spike_mutations":"Y453F"}}},{"name":"B.1.1.307","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.307"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.307"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.859855890274048}},"branch_attrs":{"mutations":{"nuc":["G1210T","G9802T","G12067T"],"nsp2":["M135I"],"nsp7":["M75I"]},"labels":{"aa":"nsp2: M135I; nsp7: M75I"}}},{"name":"B.1.1.311","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.311"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.311"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.807455539703369}},"branch_attrs":{"mutations":{"nuc":["G11230T","T24088C","G25617T"],"ORF3a":["K75N"],"nsp6":["M86I"]},"labels":{"aa":"ORF3a: K75N; nsp6: M86I"}}},{"name":"B.1.1.329","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.329"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.329"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.522212982177734}},"branch_attrs":{"mutations":{"nuc":["A2132C","A10323G","G10360A"],"nsp2":["K443Q"],"nsp5":["K90R"]},"labels":{"aa":"nsp2: K443Q; nsp5: K90R"}}},{"name":"B.1.1.348","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.348"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.348"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.967780828475952}},"branch_attrs":{"mutations":{"nuc":["C25521T","C29870A"]}}},{"name":"B.1.1.359","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.359"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.359"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.396486759185791}},"branch_attrs":{"mutations":{"nuc":["A28305G"],"N":["N11S"],"ORF9b":["M8V"]},"labels":{"aa":"N: N11S; ORF9b: M8V"}}},{"name":"B.1.1.368","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.368"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.437197208404541}},"branch_attrs":{"mutations":{"nuc":["C9996T","G27798T","G29402T"],"N":["D377Y"],"ORF7b":["A15S"],"nsp4":["S481L"]},"labels":{"aa":"N: D377Y; ORF7b: A15S; nsp4: S481L"}}},{"name":"B.1.1.371","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.371"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.371"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.790440082550049}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"nsp13":["S74P"]},"labels":{"aa":"nsp13: S74P"}}},{"name":"B.1.1.37","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.37"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.50777268409729}},"branch_attrs":{"mutations":{"nuc":["C21637T","A28169G"]}}},{"name":"B.1.1.370","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.370"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.370"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.376","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.376"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.376"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.82697057723999}},"branch_attrs":{"mutations":{"nuc":["A6716G","G11596T"],"nsp3":["S1333G"],"nsp6":["Q208H"]},"labels":{"aa":"nsp3: S1333G; nsp6: Q208H"}}},{"name":"B.1.1.374","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.374"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C344A","T1456C","C8595T","C8836T","G11222T","C22792T","T22917A","T26047G"],"ORF3a":["L219V"],"S":["L452Q"],"nsp1":["L27I"],"nsp4":["T14I"],"nsp6":["V84F"]},"labels":{"aa":"ORF3a: L219V; S: L452Q; nsp1: L27I; nsp4: T14I; nsp6: V84F","spike_mutations":"L452Q"}}},{"name":"B.1.1.378","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.378"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.7187089920043945}},"branch_attrs":{"mutations":{"nuc":["C29284T","C29870A"]}}},{"name":"B.1.1.39","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.39"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9360599517822266}},"branch_attrs":{"mutations":{"nuc":["G9130T","T27319C","G28487A","C28868T"],"N":["V72I","P199S"]},"labels":{"aa":"N: V72I, P199S"}}},{"name":"B.1.1.391","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.391"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.083807468414307}},"branch_attrs":{"mutations":{"nuc":["T7171C","C27002T"]}}},{"name":"B.1.1.398","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.398"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.421121597290039}},"branch_attrs":{"mutations":{"nuc":["C5806T"]}}},{"name":"B.1.1.409","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.409"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.409"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.404","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.404"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.653604507446289}},"branch_attrs":{"mutations":{"nuc":["T19275A","G20548T","G26211T","C26534T"],"nsp15":["D310Y"]},"labels":{"aa":"nsp15: D310Y"}}},{"name":"B.1.1.411","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.411"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.411"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.420","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.420"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.420"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.130832672119141}},"branch_attrs":{"mutations":{"nuc":["T847C","G3994T","C5178T","C5548T","A11451G","C13694T","T18132C","C21614T","T22882G","A24373G","G25839T","C28310T","T28862A"],"N":["P13S","S197T"],"ORF3a":["W149C"],"S":["L18F","N440K"],"nsp12":["T85I"],"nsp3":["T820I"],"nsp6":["Q160R"]},"labels":{"aa":"N: P13S, S197T; ORF3a: W149C; S: L18F, N440K; nsp12: T85I; nsp3: T820I; nsp6: Q160R","spike_mutations":"L18F, N440K"}}},{"name":"B.1.1.419","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.419"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.419"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.432","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.432"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.432"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0862812995910645}},"branch_attrs":{"mutations":{"nuc":["A6985T","C9319T","C12412T","T14313C"]}}},{"name":"B.1.1.44","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.44"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.218751907348633}},"branch_attrs":{"mutations":{"nuc":["G28884T"],"N":["R204L"]},"labels":{"aa":"N: R204L"}}},{"name":"B.1.1.442","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.442"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.442"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.316291809082031}},"branch_attrs":{"mutations":{"nuc":["A3879-","G3880-","A3881-","T3882-","T3883-","C3884-","C3885-","T3886-","A3887-","A3888-","A3889-","G3890-","A3891-","G3892-","G3893-","A3894-","A3895-","G3896-","T3897-","T3898-","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","A3908-","C13432T","C29409T"],"N":["T379I"],"nsp3":["E387-","I388-","P389-","K390-","E391-","E392-","V393-","K394-","P395-","F396-","I397V"]},"labels":{"aa":"N: T379I; nsp3: E387-, I388-, P389-, K390-, E391-, E392-, V393-, K394-, P395-, F396-, I397V"}}},{"name":"B.1.1.462","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.462"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.462"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.088257789611816}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.1.485","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.485"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.902052879333496}},"branch_attrs":{"mutations":{"nuc":["C745T"]}}},{"name":"B.1.1.487","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.487"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.487"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.5293731689453125}},"branch_attrs":{"mutations":{"nuc":["A20374G"],"nsp15":["I252V"]},"labels":{"aa":"nsp15: I252V"}}},{"name":"B.1.1.500","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.500"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.500"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.359736442565918}},"branch_attrs":{"mutations":{"nuc":["T23689C","C29230T"]}}},{"name":"B.1.1.52","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.52"},"qc.stopCodons.totalStopCodons":{"value":1},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":56.25},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.52"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.176274299621582}},"branch_attrs":{"mutations":{"nuc":["G8T","T9C","A12T","T14222G","T29867A"],"nsp12":["L261*"]},"labels":{"aa":"nsp12: L261*"}}},{"name":"B.1.1.525","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.525"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.525"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1C","T2C","T3478G","C8299T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12781T","A16550C","C16887T","C18252T","T21992-","A21993-","T21994-","G23012A","C23525T","A28271C","G28916T"],"N":["G215C"],"S":["Y144-","E484K","H655Y"],"nsp13":["D105A"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: G215C; S: Y144-, E484K, H655Y; nsp13: D105A; nsp6: S106-, G107-, F108-","spike_mutations":"Y144-, E484K, H655Y"}}},{"name":"B.1.1.53","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.53"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.88819694519043}},"branch_attrs":{"mutations":{"nuc":["G9890T","A20318G"],"nsp15":["E233G"],"nsp4":["A446S"]},"labels":{"aa":"nsp15: E233G; nsp4: A446S"}}},{"name":"B.1.1.57","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.57"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.502486705780029}},"branch_attrs":{"mutations":{"nuc":["C20234T"],"nsp15":["P205L"]},"labels":{"aa":"nsp15: P205L"}}},{"name":"B.1.1.63","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.63"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7540249824523926}},"branch_attrs":{"mutations":{"nuc":["C21597T","C29144T"],"S":["S12F"]},"labels":{"aa":"S: S12F","spike_mutations":"S12F"}}},{"name":"B.1.1.61","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.61"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.910613059997559}},"branch_attrs":{"mutations":{"nuc":["G18898T"],"nsp14":["V287F"]},"labels":{"aa":"nsp14: V287F"}}},{"name":"B.1.1.83","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.83"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.83"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.403122901916504}},"branch_attrs":{"mutations":{"nuc":["C1420T"]}}},{"name":"B.1.1.99","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.99"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.99"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.924996376037598}},"branch_attrs":{"mutations":{"nuc":["C28005T","C29870A"],"ORF8":["P38S"]},"labels":{"aa":"ORF8: P38S"}}},{"name":"B.1.533","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.533"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.533"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.071420192718506}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"NODE_0000590","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.10"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.221151828765869}},"branch_attrs":{"mutations":{"nuc":["C19170T","G19509A"]}},"children":[{"name":"B.1.1.10","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.221151828765869}},"branch_attrs":{"mutations":{}}},{"name":"L.3","node_attrs":{"div":20,"Nextclade_pango":{"value":"L.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.097338676452637}},"branch_attrs":{"mutations":{"nuc":["C1601T","G4399T","C4543T","G8179T","C8481T","A9453C","C19269T","T22917G","A25026T","G25244T","A26927G"],"S":["L452R","Y1155F","V1228L"],"nsp2":["L266F"],"nsp3":["M560I","P1921L"],"nsp4":["Y300S"]},"labels":{"aa":"S: L452R, Y1155F, V1228L; nsp2: L266F; nsp3: M560I, P1921L; nsp4: Y300S","spike_mutations":"L452R, Y1155F, V1228L"}}}]},{"name":"NODE_0000591","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.131749153137207}},"branch_attrs":{"mutations":{"nuc":["C13887T","C23248T"]}},"children":[{"name":"B.1.1.153","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.153"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.153"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C1912T","T9151C","C9693T","T16456C"],"nsp13":["S74P"],"nsp4":["A380V"]},"labels":{"aa":"nsp13: S74P; nsp4: A380V"}}},{"name":"B.1.1.170","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.170"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.170"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.35718297958374}},"branch_attrs":{"mutations":{"nuc":["C2062T","C5184A","C18687T"],"nsp3":["P822H"]},"labels":{"aa":"nsp3: P822H"}}}]},{"name":"NODE_0000592","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.607780456542969}},"branch_attrs":{"mutations":{"nuc":["C9120T"],"nsp4":["T189I"]},"labels":{"aa":"nsp4: T189I"}},"children":[{"name":"B.1.1.159","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.159"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.159"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.915672302246094}},"branch_attrs":{"mutations":{"nuc":["G6865T","A9204C","C15237T","C28290T"],"N":["P6L"],"ORF9b":["P3S"],"nsp3":["K1382N"],"nsp4":["D217A"]},"labels":{"aa":"N: P6L; ORF9b: P3S; nsp3: K1382N; nsp4: D217A"}}},{"name":"B.1.1.302","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.302"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.302"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4443230628967285}},"branch_attrs":{"mutations":{"nuc":["C7267T","C18032T","C20233T","G24926T","A27674T","A29350G"],"ORF7a":["Q94L"],"S":["V1122L"],"nsp13":["T599I"],"nsp15":["P205S"]},"labels":{"aa":"ORF7a: Q94L; S: V1122L; nsp13: T599I; nsp15: P205S","spike_mutations":"V1122L"}}}]},{"name":"NODE_0000593","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.96992301940918}},"branch_attrs":{"mutations":{"nuc":["C1427T"],"nsp2":["H208Y"]},"labels":{"aa":"nsp2: H208Y"}},"children":[{"name":"B.1.1.254","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.254"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.254"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.96992301940918}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.507","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.507"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.507"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["G1042A","C12253T","G19656A"]}}}]},{"name":"NODE_0000594","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.194224834442139}},"branch_attrs":{"mutations":{"nuc":["G21624T"],"S":["R21I"]},"labels":{"aa":"S: R21I","spike_mutations":"R21I"}},"children":[{"name":"B.1.1.279","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.279"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.279"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.194469928741455}},"branch_attrs":{"mutations":{"nuc":["C1419T","C4158T","C8318A","G18859T"],"nsp14":["A274S"],"nsp2":["A205V"],"nsp3":["A480V","P1867T"]},"labels":{"aa":"nsp14: A274S; nsp2: A205V; nsp3: A480V, P1867T"}}},{"name":"B.1.1.360","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.360"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.360"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.070964336395264}},"branch_attrs":{"mutations":{"nuc":["G25598T"],"ORF3a":["W69L"]},"labels":{"aa":"ORF3a: W69L"}}}]},{"name":"NODE_0000595","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.927735328674316}},"branch_attrs":{"mutations":{"nuc":["C936T","G3259T"],"nsp2":["T44I"],"nsp3":["Q180H"]},"labels":{"aa":"nsp2: T44I; nsp3: Q180H"}},"children":[{"name":"B.1.1.304","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.304"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.304"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.927735328674316}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.434","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.434"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.434"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2342G","C11591T","G17122T","C18348T","A26069G"],"ORF3a":["E226G"],"nsp13":["A296S"],"nsp2":["I513V"],"nsp6":["L207F"]},"labels":{"aa":"ORF3a: E226G; nsp13: A296S; nsp2: I513V; nsp6: L207F"}}}]},{"name":"NODE_0000596","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.98975133895874}},"branch_attrs":{"mutations":{"nuc":["C25528T"],"ORF3a":["L46F"]},"labels":{"aa":"ORF3a: L46F"}},"children":[{"name":"B.1.1.326","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.326"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.326"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.312747478485107}},"branch_attrs":{"mutations":{"nuc":["A12C","G4354A","C6573T"],"nsp3":["S1285F"]},"labels":{"aa":"nsp3: S1285F"}}},{"name":"B.1.1.8","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.8"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.98975133895874}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000597","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.590047836303711}},"branch_attrs":{"mutations":{"nuc":["A1G","C12053T","G25088T"],"S":["V1176F"],"nsp7":["L71F"]},"labels":{"aa":"S: V1176F; nsp7: L71F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.332","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.332"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.332"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["C442A","C6310T","G11417T","T16944C","G26062C"],"ORF3a":["G224R"],"nsp6":["V149F"]},"labels":{"aa":"ORF3a: G224R; nsp6: V149F"}}},{"name":"P.7","node_attrs":{"div":21,"Nextclade_pango":{"value":"P.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.7"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C1288T","C7124T","C7765T","G8027T","C9344T","G10870T","G11596T","C17172T","C17676T","C25844T","C28311T"],"N":["P13L"],"ORF3a":["T151I"],"ORF9b":["P10S"],"nsp3":["P1469S","V1770F"],"nsp4":["L264F"],"nsp6":["Q208H"]},"labels":{"aa":"N: P13L; ORF3a: T151I; ORF9b: P10S; nsp3: P1469S, V1770F; nsp4: L264F; nsp6: Q208H"}}}]},{"name":"NODE_0000598","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9660351276397705}},"branch_attrs":{"mutations":{"nuc":["G21974T"],"S":["D138Y"]},"labels":{"aa":"S: D138Y","spike_mutations":"D138Y"}},"children":[{"name":"B.1.1.397","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.397"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.451379776000977}},"branch_attrs":{"mutations":{"nuc":["T22020C","G28077T","G28975T"],"N":["M234I"],"ORF8":["V62L"],"S":["M153T"]},"labels":{"aa":"N: M234I; ORF8: V62L; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.413","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.1.413"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.413"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A604G","C3096T","G13849T","A19020T","G22992A","A26741G","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","C28291T","C29311T"],"M":["I73M"],"ORF8":["G66-","S67-","K68E"],"ORF9b":["P3L"],"S":["S477N"],"nsp12":["G137C"],"nsp3":["S126L"]},"labels":{"aa":"M: I73M; ORF8: G66-, S67-, K68E; ORF9b: P3L; S: S477N; nsp12: G137C; nsp3: S126L","spike_mutations":"S477N"}}}]},{"name":"NODE_0000599","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.683711051940918}},"branch_attrs":{"mutations":{"nuc":["T12503C","C29721T"],"nsp8":["Y138H"]},"labels":{"aa":"nsp8: Y138H"}},"children":[{"name":"B.1.1.448","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.448"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.683711051940918}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.54","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.54"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.678201675415039}},"branch_attrs":{"mutations":{"nuc":["C6762T","G25770T"],"ORF3a":["R126S"],"nsp3":["T1348I"]},"labels":{"aa":"ORF3a: R126S; nsp3: T1348I"}}}]},{"name":"NODE_0000600","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.747574806213379}},"branch_attrs":{"mutations":{"nuc":["C21648T"],"S":["T29I"]},"labels":{"aa":"S: T29I","spike_mutations":"T29I"}},"children":[{"name":"B.1.1.486","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.486"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["C12439T","C23277T","G23593T","G24368A","G25565A","C25624T","T27242C","C27630T","G28975T","G29332T","G29751T"],"N":["M234I"],"ORF3a":["S58N","H78Y"],"ORF6":["I14T"],"S":["T572I","Q677H","D936N"]},"labels":{"aa":"N: M234I; ORF3a: S58N, H78Y; ORF6: I14T; S: T572I, Q677H, D936N","spike_mutations":"T572I, Q677H, D936N"}}},{"name":"B.1.1.67","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.67"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.898261547088623}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"nsp6":["D159N"]},"labels":{"aa":"nsp6: D159N"}}}]},{"name":"NODE_0000601","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.247831344604492}},"branch_attrs":{"mutations":{"nuc":["C26060T"],"ORF3a":["T223I"]},"labels":{"aa":"ORF3a: T223I"}},"children":[{"name":"B.1.1.216","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.216"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.216"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.874875545501709}},"branch_attrs":{"mutations":{"nuc":["A1T","C5884T"]}}},{"name":"B.1.1.416","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.416"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.416"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.05353307723999}},"branch_attrs":{"mutations":{"nuc":["C16386T","C20762T"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"B.1.1.433","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.433"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.433"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.377383708953857}},"branch_attrs":{"mutations":{"nuc":["C313T","G3692T","C5007T","A11991G","G14584A","C14805T","T15114C","C15848T","G20940T","C22993G","G23580C","T23599A","G26217T","G26951C","T27900C"],"ORF3a":["L275F"],"ORF8":["F3L"],"S":["S477R","S673T","N679K"],"nsp12":["A382T","T803I"],"nsp3":["V325F","T763M"],"nsp7":["E50G"]},"labels":{"aa":"ORF3a: L275F; ORF8: F3L; S: S477R, S673T, N679K; nsp12: A382T, T803I; nsp3: V325F, T763M; nsp7: E50G","spike_mutations":"S477R, S673T, N679K"}}}]},{"name":"NODE_0000602","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.30653190612793}},"branch_attrs":{"mutations":{"nuc":["G10265A"],"nsp5":["G71S"]},"labels":{"aa":"nsp5: G71S"}},"children":[{"name":"B.1.1.27","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.27"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.767889499664307}},"branch_attrs":{"mutations":{"nuc":["C16293T"]}}},{"name":"B.1.1.301","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.301"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.301"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.301366329193115}},"branch_attrs":{"mutations":{"nuc":["A9433T","A19650G"]}}},{"name":"B.1.1.70","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.70"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.70"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.566112756729126}},"branch_attrs":{"mutations":{"nuc":["A15972G","C19718T","T28759C"],"nsp15":["T33I"]},"labels":{"aa":"nsp15: T33I"}}}]},{"name":"NODE_0000603","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.859383583068848}},"branch_attrs":{"mutations":{"nuc":["C22675T"]}},"children":[{"name":"B.1.1.273","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.273"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.273"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.873911380767822}},"branch_attrs":{"mutations":{"nuc":["A7064G"],"nsp3":["R1449G"]},"labels":{"aa":"nsp3: R1449G"}}},{"name":"B.1.1.412","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.412"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.412"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.9886064529418945}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"nsp6":["D159N"]},"labels":{"aa":"nsp6: D159N"}}},{"name":"B.1.1.56","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.56"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["T9508C","G23868T","G24794T"],"S":["G769V","A1078S"]},"labels":{"aa":"S: G769V, A1078S","spike_mutations":"G769V, A1078S"}}}]},{"name":"NODE_0000604","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.898122787475586}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"B.1.1.312","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.312"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.312"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420844554901123}},"branch_attrs":{"mutations":{"nuc":["C2455T","C14625T","C19018T","A24432T","A28081G"],"ORF8":["D63G"],"S":["Q957L"],"nsp14":["P327S"]},"labels":{"aa":"ORF8: D63G; S: Q957L; nsp14: P327S","spike_mutations":"Q957L"}}},{"name":"B.1.1.406","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.406"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.8544087409973145}},"branch_attrs":{"mutations":{"nuc":["C683T","C7051T","C7303T","C8964T","G25314T","C29296T","G29744A"],"S":["G1251V"],"nsp4":["S137L"]},"labels":{"aa":"S: G1251V; nsp4: S137L","spike_mutations":"G1251V"}}},{"name":"B.1.1.417","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.417"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.417"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.553451061248779}},"branch_attrs":{"mutations":{"nuc":["A2871G","C11455T","T12433C","C16997T","C17285T","A17739G","C19017T","G19072T","C20823T","G21800T","C25416T","G29781T"],"S":["D80Y"],"nsp13":["P254L","S350L"],"nsp14":["D345Y"],"nsp3":["N51S"]},"labels":{"aa":"S: D80Y; nsp13: P254L, S350L; nsp14: D345Y; nsp3: N51S","spike_mutations":"D80Y"}}}]},{"name":"NODE_0000605","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.167232036590576}},"branch_attrs":{"mutations":{"nuc":["G16853T"],"nsp13":["G206V"]},"labels":{"aa":"nsp13: G206V"}},"children":[{"name":"B.1.1.382","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.382"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.60129451751709}},"branch_attrs":{"mutations":{"nuc":["G6368A"],"nsp3":["G1217R"]},"labels":{"aa":"nsp3: G1217R"}}},{"name":"NODE_0000606","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.467953205108643}},"branch_attrs":{"mutations":{"nuc":["C2094T"],"nsp2":["S430L"]},"labels":{"aa":"nsp2: S430L"}},"children":[{"name":"B.1.1.34","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.34"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.467953205108643}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.528","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.528"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.528"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["A1072G","C1449T","A3868T","G9526T","G9756A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21974T","T22912G","C23604G","T26767C","C27297T","A28877T","G28878C","A28911T","C29303T"],"M":["I82T"],"N":["N213I","P344S"],"S":["D138Y","N450K","P681R"],"nsp2":["T215I"],"nsp3":["Q383H"],"nsp4":["M324I","R401H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; N: N213I, P344S; S: D138Y, N450K, P681R; nsp2: T215I; nsp3: Q383H; nsp4: M324I, R401H; nsp6: S106-, G107-, F108-","spike_mutations":"D138Y, N450K, P681R"}}}]}]},{"name":"NODE_0000607","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.25"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.116090297698975}},"branch_attrs":{"mutations":{"nuc":["A1G","A1163T"],"nsp2":["I120F"]},"labels":{"aa":"nsp2: I120F"}},"children":[{"name":"B.1.1.25","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.116090297698975}},"branch_attrs":{"mutations":{}}},{"name":"D.2","node_attrs":{"div":14,"Nextclade_pango":{"value":"D.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20F"},"partiallyAliased":{"value":"B.1.1.25.2"},"clade_nextstrain":{"value":"20F"},"clade_membership":{"value":"20F"},"placement_prior":{"value":-3.0833327770233154}},"branch_attrs":{"mutations":{"nuc":["T7540C","G16647T","C18555T","G22992A","G23401A"],"S":["S477N"]},"labels":{"aa":"S: S477N","clade":"20F","spike_mutations":"S477N"}}},{"name":"NODE_0000608","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.315"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{"nuc":["G1A","T3256C","G14202T","C19718T","C22388T","C26060T","G29227T","C29466T","A29771G"],"N":["A398V"],"ORF3a":["T223I"],"nsp12":["E254D"],"nsp15":["T33I"]},"labels":{"aa":"N: A398V; ORF3a: T223I; nsp12: E254D; nsp15: T33I"}},"children":[{"name":"AD.2","node_attrs":{"div":20,"Nextclade_pango":{"value":"AD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.5890538692474365}},"branch_attrs":{"mutations":{"nuc":["C5622T","G19542T"],"nsp14":["M501I"],"nsp3":["P968L"]},"labels":{"aa":"nsp14: M501I; nsp3: P968L"}}},{"name":"B.1.1.315","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.315"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000609","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.680613994598389}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}},"children":[{"name":"B.1.1.351","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.351"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.351"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C7231T","A9749G","C10776A","A13867C","A15489G","C16658T","G17815A","C19164T","G21724T","C23604A"],"S":["L54F","P681H"],"nsp12":["K143Q"],"nsp13":["T141I","G527R"],"nsp4":["K399E"],"nsp5":["P241H"]},"labels":{"aa":"S: L54F, P681H; nsp12: K143Q; nsp13: T141I, G527R; nsp4: K399E; nsp5: P241H","spike_mutations":"L54F, P681H"}}},{"name":"B.1.1.46","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.46"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["A1C","C1218T","C27110T","T27384C"],"nsp2":["S138L"]},"labels":{"aa":"nsp2: S138L"}}},{"name":"NODE_0000610","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8004047870635986}},"branch_attrs":{"mutations":{"nuc":["G9389A"],"nsp4":["D279N"]},"labels":{"aa":"nsp4: D279N"}},"children":[{"name":"B.1.1.354","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.354"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.354"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.217127323150635}},"branch_attrs":{"mutations":{"nuc":["A1T","G28899T"],"N":["R209I"]},"labels":{"aa":"N: R209I"}}},{"name":"B.1.1.526","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.526"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.526"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-8.332109451293945}},"branch_attrs":{"mutations":{"nuc":["G4510T","C9611T","G12167T","G14622A","C23604A","T24811C","G25250T","G25906T","G28077T","C29659T"],"ORF3a":["G172C"],"ORF8":["V62L"],"S":["P681H","V1230L"],"nsp4":["L353F"],"nsp8":["V26F"]},"labels":{"aa":"ORF3a: G172C; ORF8: V62L; S: P681H, V1230L; nsp4: L353F; nsp8: V26F","spike_mutations":"P681H, V1230L"}}}]}]},{"name":"NODE_0000611","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.33"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8493027687072754}},"branch_attrs":{"mutations":{"nuc":["T27299C","T29148C"],"N":["I292T"],"ORF6":["I33T"]},"labels":{"aa":"N: I292T; ORF6: I33T"}},"children":[{"name":"B.1.1.33","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8493027687072754}},"branch_attrs":{"mutations":{}}},{"name":"N.6","node_attrs":{"div":11,"Nextclade_pango":{"value":"N.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.6"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.92036771774292}},"branch_attrs":{"mutations":{"nuc":["C5365T","G8137T"]}}},{"name":"N.3","node_attrs":{"div":10,"Nextclade_pango":{"value":"N.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.329464435577393}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"N.4","node_attrs":{"div":11,"Nextclade_pango":{"value":"N.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.656524181365967}},"branch_attrs":{"mutations":{"nuc":["A1C","A2475G"],"nsp2":["K557R"]},"labels":{"aa":"nsp2: K557R"}}},{"name":"N.5","node_attrs":{"div":14,"Nextclade_pango":{"value":"N.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A298G","C17274T","A22803G","C25904T","G29134A"],"ORF3a":["S171L"],"S":["Q414R"]},"labels":{"aa":"ORF3a: S171L; S: Q414R","spike_mutations":"Q414R"}}},{"name":"N.9","node_attrs":{"div":16,"Nextclade_pango":{"value":"N.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.9"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["G1264T","C7600T","C7851T","T11078C","G23012A","A27853C","A29882C"],"ORF7b":["E33A"],"S":["E484K"],"nsp3":["A1711V"],"nsp6":["F36L"]},"labels":{"aa":"ORF7b: E33A; S: E484K; nsp3: A1711V; nsp6: F36L","spike_mutations":"E484K"}}}]},{"name":"NODE_0000612","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.592955112457275}},"branch_attrs":{"mutations":{"nuc":["G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.1.523","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.1.523"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.523"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["A1087G","A1610G","A2311G","A2969G","G6609T","C9430T","G10961A","G11222T","C13356T","G14126A","C16466T","G16917A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22035-","A22036-","T22478C","T23042C","A23901C","A24078T","C24642T","C25904T","G25993T","A28273T","G28907T"],"N":["G212C"],"ORF3a":["S171L","V201F"],"S":["E156-","F157-","R158-","F306L","S494P","E780A","D839V","T1027I"],"nsp10":["T111I"],"nsp12":["S229N"],"nsp13":["P77L"],"nsp2":["N269D"],"nsp3":["M84V","R1297I"],"nsp5":["V303I"],"nsp6":["V84F"]},"labels":{"aa":"N: G212C; ORF3a: S171L, V201F; S: E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I; nsp10: T111I; nsp12: S229N; nsp13: P77L; nsp2: N269D; nsp3: M84V, R1297I; nsp5: V303I; nsp6: V84F","spike_mutations":"E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I"}}},{"name":"NODE_0000613","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A1T","C3961T","G7798T","C9072T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G20578A","C21846T","T21992-","A21993-","T21994-","T23287C","C23604A","G23948C","C25276A","A27887-","A27888-","C27889-","G27890-","A27891-","A27892-","C27893-","A27894-","T27895-","G27896-","A27897-","A27898-","A27899-","T27900-","T27901-","G28209T","A28271G","C28896-","T28897-","A28898-","C29769T"],"N":["A208-","R209G"],"ORF8":["E106*"],"S":["T95I","Y144-","P681H","D796H"],"nsp15":["V320M"],"nsp3":["K1693N"],"nsp4":["T173I","A446V"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: A208-, R209G; ORF8: E106*; S: T95I, Y144-, P681H, D796H; nsp15: V320M; nsp3: K1693N; nsp4: T173I, A446V; nsp6: S106-, G107-, F108-","spike_mutations":"T95I, Y144-, P681H, D796H"}},"children":[{"name":"AZ.4","node_attrs":{"div":28,"Nextclade_pango":{"value":"AZ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2416T","G7829C","T7831A","C17569T","T27384C"],"nsp13":["P445S"],"nsp3":["V1704L"]},"labels":{"aa":"nsp13: P445S; nsp3: V1704L"}}},{"name":"NODE_0000614","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C24382T"]}},"children":[{"name":"AZ.5","node_attrs":{"div":30,"Nextclade_pango":{"value":"AZ.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T1G","G3259T","G6463T","T20994C","C29077T","A29879G"],"nsp3":["Q180H"]},"labels":{"aa":"nsp3: Q180H"}}},{"name":"NODE_0000615","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.047244071960449}},"branch_attrs":{"mutations":{"nuc":["C10116T"],"nsp5":["T21I"]},"labels":{"aa":"nsp5: T21I"}},"children":[{"name":"B.1.1.318","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.1.318"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.047244071960449}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000616","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9885480403900146}},"branch_attrs":{"mutations":{"nuc":["A3852T","G21004T"],"nsp16":["A116S"],"nsp3":["E378V"]},"labels":{"aa":"nsp16: A116S; nsp3: E378V"}},"children":[{"name":"AZ.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"AZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.056199073791504}},"branch_attrs":{"mutations":{"nuc":["C10369T","C12400T","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"AZ.3","node_attrs":{"div":28,"Nextclade_pango":{"value":"AZ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["T11850C"],"nsp7":["M3T"]},"labels":{"aa":"nsp7: M3T"}}},{"name":"AZ.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"AZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.071262836456299}},"branch_attrs":{"mutations":{"nuc":["C11345T","C11644T"],"nsp6":["L125F"]},"labels":{"aa":"nsp6: L125F"}}}]}]}]}]}]},{"name":"NODE_0000617","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7063244581222534}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14676T","C15279T","T16176C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23271A","C23604A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF8":["Q27*","R52I","Y73C"],"S":["H69-","V70-","Y144-","N501Y","A570D","P681H","T716I","S982A","D1118H"],"nsp3":["T183I","A890D","I1412T"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: D3L, S235F; ORF8: Q27*, R52I, Y73C; S: H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H; nsp3: T183I, A890D, I1412T; nsp6: S106-, G107-, F108-","clade":"Alpha","spike_mutations":"H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7063244581222534}},"branch_attrs":{"mutations":{}}},{"name":"Q.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"Q.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.1"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.273303270339966}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}}},{"name":"Q.2","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.2"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.956664800643921}},"branch_attrs":{"mutations":{"nuc":["A1752G","C6636T","G22468T","C25626T","C27752T","C28227T"],"ORF7a":["T120I"],"ORF8":["H112Y"],"nsp2":["Y316C"],"nsp3":["T1306I"]},"labels":{"aa":"ORF7a: T120I; ORF8: H112Y; nsp2: Y316C; nsp3: T1306I"}}},{"name":"NODE_0000618","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7612149715423584}},"branch_attrs":{"mutations":{"nuc":["T15096C","A28095T"],"ORF8":["K68*"]},"labels":{"aa":"ORF8: K68*"}},"children":[{"name":"Q.7","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.1349856853485107}},"branch_attrs":{"mutations":{"nuc":["A7069C","A17337G","T18018C","G28884C"],"N":["R204P"],"nsp3":["E1450D"]},"labels":{"aa":"N: R204P; nsp3: E1450D"}}},{"name":"Q.8","node_attrs":{"div":35,"Nextclade_pango":{"value":"Q.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.8"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-4.827495098114014}},"branch_attrs":{"mutations":{"nuc":["C12525T","C19164T","C25096T","A25974C","G29751T"],"ORF3a":["E194D"],"nsp8":["T145I"]},"labels":{"aa":"ORF3a: E194D; nsp8: T145I"}}}]},{"name":"NODE_0000619","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.8349626064300537}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"nsp13":["K460R"]},"labels":{"aa":"nsp13: K460R"}},"children":[{"name":"Q.3","node_attrs":{"div":33,"Nextclade_pango":{"value":"Q.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.3"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.3964552879333496}},"branch_attrs":{"mutations":{"nuc":["G5023A","G10396T","G20962A","G26730C"],"M":["V70L"],"nsp16":["D102N"],"nsp3":["M768I"]},"labels":{"aa":"M: V70L; nsp16: D102N; nsp3: M768I"}}},{"name":"Q.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.4"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.756404399871826}},"branch_attrs":{"mutations":{"nuc":["C335T","A4964G","C7224T","A12162G","A23604G"],"S":["H681R"],"nsp1":["R24C"],"nsp3":["T749A","A1502V"],"nsp8":["Q24R"]},"labels":{"aa":"S: H681R; nsp1: R24C; nsp3: T749A, A1502V; nsp8: Q24R","spike_mutations":"H681R"}}}]}]},{"name":"NODE_0000620","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.3051984310150146}},"branch_attrs":{"mutations":{"nuc":["C313T"]}},"children":[{"name":"B.1.1.181","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.181"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.181"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.882091045379639}},"branch_attrs":{"mutations":{"nuc":["C14724T"]}}},{"name":"B.1.1.214","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.214"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.214"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-2.8961424827575684}},"branch_attrs":{"mutations":{"nuc":["C18167T","G21518T","G28975T"],"N":["M234I"],"nsp14":["P43L"],"nsp16":["R287I"]},"labels":{"aa":"N: M234I; nsp14: P43L; nsp16: R287I"}}},{"name":"B.1.1.305","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.305"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.305"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.704046726226807}},"branch_attrs":{"mutations":{"nuc":["G28396A"],"ORF9b":["G38D"]},"labels":{"aa":"ORF9b: G38D"}}},{"name":"B.1.1.50","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.50"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.179980754852295}},"branch_attrs":{"mutations":{"nuc":["G4510A","G15438T","G25785T"],"ORF3a":["W131C"],"nsp12":["M666I"]},"labels":{"aa":"ORF3a: W131C; nsp12: M666I"}}},{"name":"B.1.1.51","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.51"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.484864234924316}},"branch_attrs":{"mutations":{"nuc":["T10453C","C11195T"],"nsp6":["L75F"]},"labels":{"aa":"nsp6: L75F"}}},{"name":"NODE_0000621","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.787297248840332}},"branch_attrs":{"mutations":{"nuc":["C9286T"]}},"children":[{"name":"B.1.1.284","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.284"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.284"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.2298262119293213}},"branch_attrs":{"mutations":{"nuc":["T4346C","C10376T","C14708T","C28725T","G29692T"],"N":["P151L"],"nsp12":["A423V"],"nsp3":["S543P"],"nsp5":["P108S"]},"labels":{"aa":"N: P151L; nsp12: A423V; nsp3: S543P; nsp5: P108S"}}},{"name":"B.1.1.47","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.47"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.770909309387207}},"branch_attrs":{"mutations":{"nuc":["C19763T"],"nsp15":["T48I"]},"labels":{"aa":"nsp15: T48I"}}}]},{"name":"NODE_0000622","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.306"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0954976081848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C5700A"],"nsp3":["A994D"]},"labels":{"aa":"nsp3: A994D"}},"children":[{"name":"AE.8","node_attrs":{"div":15,"Nextclade_pango":{"value":"AE.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306.8"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9437592029571533}},"branch_attrs":{"mutations":{"nuc":["C1347T","C1943T","C6031T","T7153C","G13975T"],"nsp12":["G179C"],"nsp2":["P181L","R380C"]},"labels":{"aa":"nsp12: G179C; nsp2: P181L, R380C"}}},{"name":"AE.1","node_attrs":{"div":11,"Nextclade_pango":{"value":"AE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.030422210693359}},"branch_attrs":{"mutations":{"nuc":["C25791T"]}}},{"name":"B.1.1.306","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.306"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0954976081848145}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000623","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.4629838466644287}},"branch_attrs":{"mutations":{"nuc":["T19839C"]}},"children":[{"name":"B.1.1.221","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.221"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.221"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.094820976257324}},"branch_attrs":{"mutations":{"nuc":["C21646T","C26846T"]}}},{"name":"B.1.1.220","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.220"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.220"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.65780782699585}},"branch_attrs":{"mutations":{"nuc":["C26681T"]}}},{"name":"B.1.1.291","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.291"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.291"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9559080600738525}},"branch_attrs":{"mutations":{"nuc":["C15933T","C29784T"]}}},{"name":"B.1.1.316","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.316"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.316"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.084707736968994}},"branch_attrs":{"mutations":{"nuc":["C21757T","G23593C","A23756T","G29751T"],"S":["Q677H","T732S"]},"labels":{"aa":"S: Q677H, T732S","spike_mutations":"Q677H, T732S"}}},{"name":"B.1.1.317","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.317"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.317"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8110387325286865}},"branch_attrs":{"mutations":{"nuc":["C28905T"],"N":["A211V"]},"labels":{"aa":"N: A211V"}}},{"name":"B.1.1.459","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.459"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.459"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.982537269592285}},"branch_attrs":{"mutations":{"nuc":["C16971T","A21137G","C24099T"],"S":["A846V"],"nsp16":["K160R"]},"labels":{"aa":"S: A846V; nsp16: K160R","spike_mutations":"A846V"}}},{"name":"B.1.1.464","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.464"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.464"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.04607629776001}},"branch_attrs":{"mutations":{"nuc":["C12025T","C23707T"]}}},{"name":"B.1.1.521","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.521"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.521"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{"nuc":["C4927T","C9693T","C18744T","C23422T"],"nsp4":["A380V"]},"labels":{"aa":"nsp4: A380V"}}},{"name":"R.1","node_attrs":{"div":20,"Nextclade_pango":{"value":"R.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.316.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.117560863494873}},"branch_attrs":{"mutations":{"nuc":["C14340T","G17551A","C18877T","A19167G","C19274A","G22017T","G23012A","G23868T","T26604C","C27213T","C28833T","G29527T"],"M":["F28L"],"N":["S187L","Q418H"],"S":["W152L","E484K","G769V"],"nsp13":["G439R"],"nsp14":["P412H"]},"labels":{"aa":"M: F28L; N: S187L, Q418H; S: W152L, E484K, G769V; nsp13: G439R; nsp14: P412H","spike_mutations":"W152L, E484K, G769V"}}},{"name":"NODE_0000624","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.707209348678589}},"branch_attrs":{"mutations":{"nuc":["A23756G"],"S":["T732A"]},"labels":{"aa":"S: T732A","spike_mutations":"T732A"}},"children":[{"name":"B.1.1.222","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.222"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.222"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.707209348678589}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.418","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.1.418"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.418"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["C1812T","A8072G","A10323G","A21194G","C22480T","G24197T","G24415T","G29751C"],"S":["A879S"],"nsp16":["D179G"],"nsp2":["A336V"],"nsp3":["N1785D"],"nsp5":["K90R"]},"labels":{"aa":"S: A879S; nsp16: D179G; nsp2: A336V; nsp3: N1785D; nsp5: K90R","spike_mutations":"A879S"}}}]}]},{"name":"internal_1fa9","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.250203609466553}},"branch_attrs":{"mutations":{"nuc":["G25088T"],"S":["V1176F"]},"labels":{"aa":"S: V1176F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.28","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.250203609466553}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000626","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.622063636779785}},"branch_attrs":{"mutations":{"nuc":["C12053T","C28253T"],"nsp7":["L71F"]},"labels":{"aa":"nsp7: L71F"}},"children":[{"name":"P.2","node_attrs":{"div":17,"Nextclade_pango":{"value":"P.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.341432809829712}},"branch_attrs":{"mutations":{"nuc":["C100T","T10667G","C11824T","G23012A","G28628T","G28975T","C29754T"],"N":["A119S","M234I"],"S":["E484K"],"nsp5":["L205V"]},"labels":{"aa":"N: A119S, M234I; S: E484K; nsp5: L205V","spike_mutations":"E484K"}}},{"name":"P.6","node_attrs":{"div":23,"Nextclade_pango":{"value":"P.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.6"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C1077T","G2534T","C3736T","C7043T","C8980T","C10029T","A14113G","G21305A","G23587C","G23593T","C24382T","C25665T","G26172T"],"ORF3a":["M260I"],"S":["Q675H","Q677H"],"nsp12":["T225A"],"nsp16":["R216H"],"nsp2":["P91L","V577F"],"nsp3":["P1442S"],"nsp4":["T492I"]},"labels":{"aa":"ORF3a: M260I; S: Q675H, Q677H; nsp12: T225A; nsp16: R216H; nsp2: P91L, V577F; nsp3: P1442S; nsp4: T492I","spike_mutations":"Q675H, Q677H"}}}]},{"name":"NODE_0000627","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-6.379853248596191}},"branch_attrs":{"mutations":{"nuc":["C11450A","A28271C"],"nsp6":["Q160K"]},"labels":{"aa":"nsp6: Q160K"}},"children":[{"name":"P.4","node_attrs":{"div":28,"Nextclade_pango":{"value":"P.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A136G","G1811A","C3177T","C9693T","T9867C","C12008T","C12880T","A15932G","G18756T","C20436T","T22054G","C22079A","T22917G","C23673T","A23720G","G25540A","C28253T","C28932T"],"N":["A220V"],"ORF3a":["V50I"],"S":["N164K","Q173K","L452R","S704L","I720V"],"nsp12":["Y831C"],"nsp2":["A336T"],"nsp3":["P153L"],"nsp4":["A380V","L438P"],"nsp7":["L56F"]},"labels":{"aa":"N: A220V; ORF3a: V50I; S: N164K, Q173K, L452R, S704L, I720V; nsp12: Y831C; nsp2: A336T; nsp3: P153L; nsp4: A380V, L438P; nsp7: L56F","spike_mutations":"N164K, Q173K, L452R, S704L, I720V"}}},{"name":"P.5","node_attrs":{"div":27,"Nextclade_pango":{"value":"P.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5175T","C8950T","C9891T","T10264C","C11152T","C13275T","T14103C","C14571T","T21568A","C21602A","C21721T","C21846T","G23012C","A23064C","C24904T","C28271T","C28531T","G28917T"],"N":["G215V"],"ORF9b":["T83I"],"S":["F2L","Q14K","T95I","E484Q","N501T"],"nsp10":["P84L"],"nsp3":["T819I"],"nsp4":["A446V"]},"labels":{"aa":"N: G215V; ORF9b: T83I; S: F2L, Q14K, T95I, E484Q, N501T; nsp10: P84L; nsp3: T819I; nsp4: A446V","spike_mutations":"F2L, Q14K, T95I, E484Q, N501T"}}}]},{"name":"NODE_0000628","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.552827835083008}},"branch_attrs":{"mutations":{"nuc":["G23012A","A23063T"],"S":["E484K","N501Y"]},"labels":{"aa":"S: E484K, N501Y","spike_mutations":"E484K, N501Y"}},"children":[{"name":"P.3","node_attrs":{"div":26,"Nextclade_pango":{"value":"P.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Theta"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21E (Theta)"},"partiallyAliased":{"value":"B.1.1.28.3"},"clade_nextstrain":{"value":"21E"},"clade_membership":{"value":"21E"},"placement_prior":{"value":-4.4443230628967285}},"branch_attrs":{"mutations":{"nuc":["A4926G","C7564A","T9867C","C11308A","C12049T","C12053T","C17074T","C17339T","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","A22356G","T23341C","C23604A","T24187A","G24836A","C24863T","A27897C","A28271-","C29724T"],"ORF8":["K2Q"],"S":["L141-","G142-","V143-","Y265C","P681H","E1092K","H1101Y"],"nsp13":["L280F","A368V"],"nsp3":["D736G"],"nsp4":["L438P"],"nsp6":["D112E"],"nsp7":["L71F"]},"labels":{"aa":"ORF8: K2Q; S: L141-, G142-, V143-, Y265C, P681H, E1092K, H1101Y; nsp13: L280F, A368V; nsp3: D736G; nsp4: L438P; nsp6: D112E; nsp7: L71F","clade":"Theta","spike_mutations":"L141-, G142-, V143-, Y265C, P681H, E1092K, H1101Y"}}},{"name":"NODE_0000629","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{"nuc":["T733C","C2749T","C3828T","A5648C","A6319G","A6613G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12778T","C13860T","G17259T","C21614T","C21621A","C21638T","G21974T","G22132T","A22812C","C23525T","C24642T","T26149C","G28167A","C28512G","A28877T","G28878C","T29834A"],"N":["P80R"],"ORF3a":["S253P"],"ORF8":["E92K"],"ORF9b":["Q77E"],"S":["L18F","T20N","P26S","D138Y","R190S","K417T","H655Y","T1027I"],"nsp13":["E341D"],"nsp3":["S370L","K977Q"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P80R; ORF3a: S253P; ORF8: E92K; ORF9b: Q77E; S: L18F, T20N, P26S, D138Y, R190S, K417T, H655Y, T1027I; nsp13: E341D; nsp3: S370L, K977Q; nsp6: S106-, G107-, F108-","clade":"Gamma","spike_mutations":"L18F, T20N, P26S, D138Y, R190S, K417T, H655Y, T1027I"}},"children":[{"name":"P.1","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{}}},{"name":"P.1.1","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.7353131771087646}},"branch_attrs":{"mutations":{"nuc":["T13851C"]}}},{"name":"P.1.11","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.11"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.509119987487793}},"branch_attrs":{"mutations":{"nuc":["C7945T","C23604G"],"S":["P681R"]},"labels":{"aa":"S: P681R","spike_mutations":"P681R"}}},{"name":"P.1.14","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.14"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.8808486461639404}},"branch_attrs":{"mutations":{"nuc":["A1G","G9105A","C23380T"],"nsp4":["S184N"]},"labels":{"aa":"nsp4: S184N"}}},{"name":"P.1.12.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"P.1.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.12.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["T3592C","T14769G","G20925A","A22298G","C22413T","T23599A","C25613T","C25844T","T28251G","C28253T"],"ORF3a":["S74F","T151I"],"ORF8":["F120V"],"S":["R246G","T284I","N679K"]},"labels":{"aa":"ORF3a: S74F, T151I; ORF8: F120V; S: R246G, T284I, N679K","spike_mutations":"R246G, T284I, N679K"}}},{"name":"P.1.12","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.12"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{}}},{"name":"P.1.16","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.16"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.7957029342651367}},"branch_attrs":{"mutations":{"nuc":["A25746G"],"ORF3a":["I118M"]},"labels":{"aa":"ORF3a: I118M"}}},{"name":"P.1.15","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.15"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.483485460281372}},"branch_attrs":{"mutations":{"nuc":["A2596G","C18129T"]}}},{"name":"P.1.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.4"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.011761665344238}},"branch_attrs":{"mutations":{"nuc":["T23599G"],"S":["N679K"]},"labels":{"aa":"S: N679K","spike_mutations":"N679K"}}},{"name":"P.1.6","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.6"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10615T","C15714T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}},{"name":"P.1.7.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.7.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T3049C","C10116T","C23604A"],"S":["P681H"],"nsp5":["T21I"]},"labels":{"aa":"S: P681H; nsp5: T21I","spike_mutations":"P681H"}}},{"name":"NODE_0000630","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.10"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.013175010681152}},"branch_attrs":{"mutations":{"nuc":["A1T","C1427T"],"nsp2":["H208Y"]},"labels":{"aa":"nsp2: H208Y"}},"children":[{"name":"P.1.10","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.013175010681152}},"branch_attrs":{"mutations":{}}},{"name":"P.1.10.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.112314701080322}},"branch_attrs":{"mutations":{"nuc":["C2841T","G4300T","C13329T","C26873T"],"nsp10":["T102I"],"nsp3":["A41V"]},"labels":{"aa":"nsp10: T102I; nsp3: A41V"}}}]},{"name":"NODE_0000631","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.17"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A1T","C346T","C28603T"]}},"children":[{"name":"P.1.17","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"P.1.17.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A6704G","G19999T","C21707T"],"S":["H49Y"],"nsp15":["V127F"],"nsp3":["N1329D"]},"labels":{"aa":"S: H49Y; nsp15: V127F; nsp3: N1329D","spike_mutations":"H49Y"}}}]},{"name":"NODE_0000632","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["T592C","A4040G","C9891T"],"nsp3":["I441V"],"nsp4":["A446V"]},"labels":{"aa":"nsp3: I441V; nsp4: A446V"}},"children":[{"name":"P.1.9","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.9"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C6040T","C18647T","G23587C"],"S":["Q675H"],"nsp14":["P203L"]},"labels":{"aa":"S: Q675H; nsp14: P203L","spike_mutations":"Q675H"}}},{"name":"P.1.8","node_attrs":{"div":42,"Nextclade_pango":{"value":"P.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.8"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A20055G","C22971A","C23604G","G25266T","C26039T","G27915T"],"ORF3a":["S216L"],"ORF8":["G8*"],"S":["T470N","P681R","C1235F"]},"labels":{"aa":"ORF3a: S216L; ORF8: G8*; S: T470N, P681R, C1235F","spike_mutations":"T470N, P681R, C1235F"}}}]},{"name":"NODE_0000633","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.685761451721191}},"branch_attrs":{"mutations":{"nuc":["C1912T"]}},"children":[{"name":"P.1.13","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.13"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.1822357177734375}},"branch_attrs":{"mutations":{"nuc":["G10610T"],"nsp5":["V186F"]},"labels":{"aa":"nsp5: V186F"}}},{"name":"P.1.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"P.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.2"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.205961227416992}},"branch_attrs":{"mutations":{"nuc":["A2550G","C5724T","G25855T","C28789T"],"ORF3a":["D155Y"],"nsp2":["D582G"],"nsp3":["T1002I"]},"labels":{"aa":"ORF3a: D155Y; nsp2: D582G; nsp3: T1002I"}}},{"name":"P.1.7","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.7"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.55728816986084}},"branch_attrs":{"mutations":{"nuc":["C16293T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}}]}]}]}]},{"name":"NODE_0000634","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.009088039398193}},"branch_attrs":{"mutations":{"nuc":["C23731T"]}},"children":[{"name":"B.1.1.375","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.1.375"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.375"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.222192764282227}},"branch_attrs":{"mutations":{"nuc":["C2509T","C6781T","C13536T","G17027T","C18747T","G22992A","A23233G","G28048A","G29425T"],"N":["Q384H"],"ORF8":["R52K"],"S":["S477N"],"nsp13":["S264I"]},"labels":{"aa":"N: Q384H; ORF8: R52K; S: S477N; nsp13: S264I","spike_mutations":"S477N"}}},{"name":"NODE_0000635","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.315249443054199}},"branch_attrs":{"mutations":{"nuc":["G10097A"],"nsp5":["G15S"]},"labels":{"aa":"nsp5: G15S"}},"children":[{"name":"B.1.1.369","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.369"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.369"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7882320880889893}},"branch_attrs":{"mutations":{"nuc":["G28580T"],"N":["D103Y"]},"labels":{"aa":"N: D103Y"}}},{"name":"B.1.1.372","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.372"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.372"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.315249443054199}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000636","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-3.7465412616729736}},"branch_attrs":{"mutations":{"nuc":["A1G","C4002T","C13536T"],"nsp3":["T428I"]},"labels":{"aa":"nsp3: T428I","clade":"20D"}},"children":[{"name":"B.1.1.1","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-3.7465412616729736}},"branch_attrs":{"mutations":{}}},{"name":"C.11","node_attrs":{"div":16,"Nextclade_pango":{"value":"C.11"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.11"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["T3G","T8071C","G13201A","C27804T"]}}},{"name":"C.14","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.14"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.14"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.6111273765563965}},"branch_attrs":{"mutations":{"nuc":["G29179T"]}}},{"name":"C.13","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.13"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.13"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.601932048797607}},"branch_attrs":{"mutations":{"nuc":["A21131G"],"nsp16":["Q158R"]},"labels":{"aa":"nsp16: Q158R"}}},{"name":"C.23","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.23"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.903609752655029}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}}},{"name":"C.26","node_attrs":{"div":15,"Nextclade_pango":{"value":"C.26"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.26"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.097338676452637}},"branch_attrs":{"mutations":{"nuc":["G1T","T8278C","G12661A","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-","A29866-","T29867-","G29868-","A29869-","C29870-","A29871-","A29872-","A29873-"]}}},{"name":"C.33","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.33"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.33"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.331241130828857}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}}},{"name":"C.35","node_attrs":{"div":15,"Nextclade_pango":{"value":"C.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.35"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.0756001472473145}},"branch_attrs":{"mutations":{"nuc":["G1T","G5950T","G19732T"],"nsp15":["V38F"],"nsp3":["K1077N"]},"labels":{"aa":"nsp15: V38F; nsp3: K1077N"}}},{"name":"C.29","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.29"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.694921016693115}},"branch_attrs":{"mutations":{"nuc":["T27900C"],"ORF8":["F3L"]},"labels":{"aa":"ORF8: F3L"}}},{"name":"C.32","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.32"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["C14877T"]}}},{"name":"C.4","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.4"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["A4G","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"C.38","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.38"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A4307C","C4763T","C5812T","G6609T","A9103C","C9286T","A11201G","G11417T","C19862T","C21057T","C21727T","T21752A","G23012A","G23948T","T26112C","T26767C","C27925A","C28311T","C28905T","G29405C"],"M":["I82T"],"N":["P13L","A211V","E378Q"],"ORF8":["T11K"],"ORF9b":["P10S"],"S":["W64R","E484K","D796Y"],"nsp15":["A81V"],"nsp3":["K530Q","H682Y","R1297I"],"nsp4":["E183D"],"nsp6":["T77A","V149F"]},"labels":{"aa":"M: I82T; N: P13L, A211V, E378Q; ORF8: T11K; ORF9b: P10S; S: W64R, E484K, D796Y; nsp15: A81V; nsp3: K530Q, H682Y, R1297I; nsp4: E183D; nsp6: T77A, V149F","spike_mutations":"W64R, E484K, D796Y"}}},{"name":"NODE_0000637","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.791935920715332}},"branch_attrs":{"mutations":{"nuc":["C18747T","G29425T"],"N":["Q384H"]},"labels":{"aa":"N: Q384H"}},"children":[{"name":"C.1.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"C.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["G569A","C2485T","C5175T","A7699G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21969T","G22132T","A22206G","C22210T","G22289-","C22290-","T22291-","T22907C","G23012A","A23063T","C23525T","T23599A","C23709T","G26155-","T26156-","T26157-","C28311T","T28516C"],"N":["P13L"],"ORF3a":["V255-"],"ORF9b":["P10S","M78T"],"S":["C136F","R190S","D215G","A243-","Y449H","E484K","N501Y","H655Y","N679K","T716I"],"nsp1":["E102K"],"nsp3":["T819I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P13L; ORF3a: V255-; ORF9b: P10S, M78T; S: C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I; nsp1: E102K; nsp3: T819I; nsp6: S106-, G107-, F108-","spike_mutations":"C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I"}}},{"name":"C.1","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.791935920715332}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000638","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.4457597732543945}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"C.16","node_attrs":{"div":16,"Nextclade_pango":{"value":"C.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.16"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.295919418334961}},"branch_attrs":{"mutations":{"nuc":["G3302A","C9693T","G29422T"],"nsp3":["E195K"],"nsp4":["A380V"]},"labels":{"aa":"nsp3: E195K; nsp4: A380V"}}},{"name":"C.40","node_attrs":{"div":23,"Nextclade_pango":{"value":"C.40"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"S:245-246,ORF3a:258-276"},"designation_date":{"value":"2021-08-27"},"qc.frameShifts.frameShifts":{"value":"S:245-246"},"qc.frameShifts.totalFrameShifts":{"value":1},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.40"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2094T","A3069G","C9891T","A10982G","A12820G","C16466T","G22205C","T22292-","G22299-","A22300-","A22301-","G22302-","T22303-","C23481T","C24138A","A26161-","A28271-","G28917T"],"N":["G215V"],"ORF3a":["N257-"],"S":["D215H","L244-","S247-","S640F","T859N"],"nsp13":["P77L"],"nsp2":["S430L"],"nsp3":["D117G"],"nsp4":["A446V"],"nsp6":["K4E"]},"labels":{"aa":"N: G215V; ORF3a: N257-; S: D215H, L244-, S247-, S640F, T859N; nsp13: P77L; nsp2: S430L; nsp3: D117G; nsp4: A446V; nsp6: K4E","spike_mutations":"D215H, L244-, S247-, S640F, T859N"}}}]},{"name":"NODE_0000639","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.2"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.998661518096924}},"branch_attrs":{"mutations":{"nuc":["T14345C","G18292T"],"nsp12":["L302S"],"nsp14":["A85S"]},"labels":{"aa":"nsp12: L302S; nsp14: A85S"}},"children":[{"name":"C.2.1","node_attrs":{"div":22,"Nextclade_pango":{"value":"C.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["G922T","T8323C","T15437C","C18501T","A23064C","C25624T","C28453T","C29642T"],"ORF10":["Q29*"],"ORF3a":["H78Y"],"ORF9b":["A57V"],"S":["N501T"],"nsp12":["M666T"]},"labels":{"aa":"ORF10: Q29*; ORF3a: H78Y; ORF9b: A57V; S: N501T; nsp12: M666T","spike_mutations":"N501T"}}},{"name":"C.2","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.998661518096924}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9cca","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.36"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.5506086349487305}},"branch_attrs":{"mutations":{"nuc":["G28908T"],"N":["G212V"]},"labels":{"aa":"N: G212V"}},"children":[{"name":"C.36","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.5506086349487305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000641","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.36.3"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G569A","C2841T","G5180A","C7124T","G9203A","G9929A","C11325T","T11337C","C12534T","G16549T","C17766T","C21597T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22016A","A22600C","T22917G","G23593T","G24257T","T26767C","G27882T","A28271-"],"M":["I82T"],"ORF7b":["A43S"],"S":["S12F","H69-","V70-","W152R","R346S","L452R","Q677H","A899S"],"nsp1":["E102K"],"nsp13":["D105Y"],"nsp3":["A41V","D821N","P1469S"],"nsp4":["D217N","D459N"],"nsp6":["S118L","L122S"],"nsp8":["T148I"]},"labels":{"aa":"M: I82T; ORF7b: A43S; S: S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S; nsp1: E102K; nsp13: D105Y; nsp3: A41V, D821N, P1469S; nsp4: D217N, D459N; nsp6: S118L, L122S; nsp8: T148I","spike_mutations":"S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S"}},"children":[{"name":"C.36.3.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"C.36.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C6706T","C17822T","C18189T","G22992A","T24811C","T25729C","A29040G","C29632T"],"N":["K256R"],"ORF3a":["Y113H"],"S":["S477N"],"nsp13":["P529L"]},"labels":{"aa":"N: K256R; ORF3a: Y113H; S: S477N; nsp13: P529L","spike_mutations":"S477N"}}},{"name":"C.36.3","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.36.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000642","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9867C","T22917A","C28253T","A28271C"],"S":["L452Q"],"nsp4":["L438P"]},"labels":{"aa":"S: L452Q; nsp4: L438P","spike_mutations":"L452Q"}},"children":[{"name":"C.39","node_attrs":{"div":31,"Nextclade_pango":{"value":"C.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.39"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2110T","C4763T","C6726T","C7113T","T7348G","C11345T","C14585T","C15194A","C21588T","G22131A","C22997T","T26038C","C26366T","C27128T","A28742G"],"E":["A41V"],"N":["I157V"],"ORF3a":["S216P"],"S":["P9L","R190K","P479S"],"nsp12":["A382V","A585D"],"nsp3":["H682Y","T1336I","T1465I","N1543K"],"nsp6":["L125F"]},"labels":{"aa":"E: A41V; N: I157V; ORF3a: S216P; S: P9L, R190K, P479S; nsp12: A382V, A585D; nsp3: H682Y, T1336I, T1465I, N1543K; nsp6: L125F","spike_mutations":"P9L, R190K, P479S"}}},{"name":"NODE_0000643","node_attrs":{"div":28,"Nextclade_pango":{"value":"C.37"},"clade_who":{"value":"Lambda"},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{"nuc":["C7124T","T7424G","C9857T","C10029T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21786T","C21789T","G22299-","A22300-","A22301-","G22302-","T22303-","T22304-","A22305-","T22306-","T22307-","T22308-","G22309-","A22310-","C22311-","T22312-","C22313-","C22314-","T22315-","G22316-","G22317-","T22318-","G22319-","T23031C","C24138A","C26894T","C28271T","C28311T","G28913T","C29311T"],"N":["P13L","G214C"],"ORF9b":["P10S"],"S":["G75V","T76I","R246-","S247-","Y248-","L249-","T250-","P251-","G252-","D253N","F490S","T859N"],"nsp3":["P1469S","F1569V"],"nsp4":["T492I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P13L, G214C; ORF9b: P10S; S: G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N; nsp3: P1469S, F1569V; nsp4: T492I; nsp6: S106-, G107-, F108-","clade":"Lambda","spike_mutations":"G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N"}},"children":[{"name":"C.37","node_attrs":{"div":28,"Nextclade_pango":{"value":"C.37"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Lambda"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{}}},{"name":"C.37.1","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.37.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Lambda"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37.1"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C20806T","T25760C","A28877T","G28878C"],"ORF3a":["I123T"]},"labels":{"aa":"ORF3a: I123T"}}}]}]}]}]}]},{"name":"NODE_0000644","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.207627296447754}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"nsp4":["T492I"]},"labels":{"aa":"nsp4: T492I"}},"children":[{"name":"AT.1","node_attrs":{"div":32,"Nextclade_pango":{"value":"AT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.370.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1392T","G3281T","A3542G","A5176G","C7005A","T9070C","C9778T","A11451G","T12620A","C16985A","G17562T","G19180T","C20759T","C21588T","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","A22206G","A22296C","G23012A","G23900A","C24370T","T25675A","G26211T","C26568A","G28079T","A28271G"],"M":["L16I"],"ORF3a":["L95M"],"S":["P9L","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","D215G","H245P","E484K","E780K"],"nsp13":["T250N"],"nsp14":["V381L"],"nsp16":["A34V"],"nsp2":["S196L"],"nsp3":["V188F","T275A","T1429N"],"nsp6":["Q160R"],"nsp8":["S177T"]},"labels":{"aa":"M: L16I; ORF3a: L95M; S: P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K; nsp13: T250N; nsp14: V381L; nsp16: A34V; nsp2: S196L; nsp3: V188F, T275A, T1429N; nsp6: Q160R; nsp8: S177T","spike_mutations":"P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K"}}},{"name":"NODE_0000645","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.820734977722168}},"branch_attrs":{"mutations":{"nuc":["C22995A","C23604A"],"S":["T478K","P681H"]},"labels":{"aa":"S: T478K, P681H","spike_mutations":"T478K, P681H"}},"children":[{"name":"B.1.1.519","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.519"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-2.7774267196655273}},"branch_attrs":{"mutations":{"nuc":["C203T","C222T","C3140T","C10954T","A11117G","C12789T","T19839C","C21306T","A23756G","C29197T"],"S":["T732A"],"nsp3":["P141S"],"nsp6":["I49V"],"nsp9":["T35I"]},"labels":{"aa":"S: T732A; nsp3: P141S; nsp6: I49V; nsp9: T35I","spike_mutations":"T732A"}}},{"name":"21M","node_attrs":{"div":40,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-3.696544885635376}},"branch_attrs":{"mutations":{"nuc":["C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","A23013C","A23040G","A23055G","A23063T","T23075C","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C26270T","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371F","S373P","S375F","K417N","N440K","G446S","S477N","E484A","Q493R","Q498R","N501Y","Y505H","H655Y","N679K","N764K","D796Y","Q954H","N969K"],"nsp14":["I42V"],"nsp5":["P132H"],"nsp6":["S106-","G107-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-; ORF9b: P10S, E27-, N28-, A29-; S: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K; nsp14: I42V; nsp5: P132H; nsp6: S106-, G107-","clade":"Omicron","spike_mutations":"A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"NODE_0000647","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.9919705390930176}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"S":["F371L","G496S","T547K","N856K","L981F"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp6":["L105-","I189V"]},"labels":{"aa":"M: D3G; S: F371L, G496S, T547K, N856K, L981F; nsp3: K38R, S1265-, L1266I, A1892T; nsp6: L105-, I189V","clade":"21K","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}},"children":[{"name":"BA.1","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.9919705390930176}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.12","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.12"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7732186317443848}},"branch_attrs":{"mutations":{"nuc":["A5T","G22487C","C28315T"],"ORF9b":["A11V"],"S":["E309Q"]},"labels":{"aa":"ORF9b: A11V; S: E309Q","spike_mutations":"E309Q"}}},{"name":"BA.1.10","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.10"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.681899070739746}},"branch_attrs":{"mutations":{"nuc":["C21T","A17042G"],"nsp13":["Y269C"]},"labels":{"aa":"nsp13: Y269C"}}},{"name":"BA.1.18","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.18"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.3796184062957764}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"nsp3":["T1004I"]},"labels":{"aa":"nsp3: T1004I"}}},{"name":"BA.1.2","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.660147190093994}},"branch_attrs":{"mutations":{"nuc":["C7420T","C11669T"],"nsp6":["R233C"]},"labels":{"aa":"nsp6: R233C"}}},{"name":"BA.1.19","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.19"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.5513505935668945}},"branch_attrs":{"mutations":{"nuc":["A1G","C21034T"],"nsp16":["L126F"]},"labels":{"aa":"nsp16: L126F"}}},{"name":"BA.1.20","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.20"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.5852789878845215}},"branch_attrs":{"mutations":{"nuc":["C11950T","C28472T"],"N":["P67S"]},"labels":{"aa":"N: P67S"}}},{"name":"BA.1.22","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.22"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.7762668132781982}},"branch_attrs":{"mutations":{"nuc":["C21T","G3182A","G5515T"],"nsp3":["E155K"]},"labels":{"aa":"nsp3: E155K"}}},{"name":"BA.1.24","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.24"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.808385372161865}},"branch_attrs":{"mutations":{"nuc":["G22580A","G28378T"],"ORF9b":["R32L"],"S":["E340K"]},"labels":{"aa":"ORF9b: R32L; S: E340K","spike_mutations":"E340K"}}},{"name":"BA.1.3","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.336390972137451}},"branch_attrs":{"mutations":{"nuc":["C21T","A3481G","C8645T"],"nsp4":["H31Y"]},"labels":{"aa":"nsp4: H31Y"}}},{"name":"BA.1.23","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.23"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.952954292297363}},"branch_attrs":{"mutations":{"nuc":["G22599C","T22926G","A22935T","C23013T","C23625T"],"S":["R346T","L455W","K458M","A484V","A688V"]},"labels":{"aa":"S: R346T, L455W, K458M, A484V, A688V","spike_mutations":"R346T, L455W, K458M, A484V, A688V"}}},{"name":"BA.1.4","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.4"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.1539411544799805}},"branch_attrs":{"mutations":{"nuc":["C21T","G23351A"],"S":["V597I"]},"labels":{"aa":"S: V597I","spike_mutations":"V597I"}}},{"name":"BA.1.6","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.6"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.269890308380127}},"branch_attrs":{"mutations":{"nuc":["C21T","C17639T"],"nsp13":["S468L"]},"labels":{"aa":"nsp13: S468L"}}},{"name":"BA.1.5","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.5"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.170540809631348}},"branch_attrs":{"mutations":{"nuc":["C21T","C2091T","C24054T"],"S":["A831V"],"nsp2":["T429I"]},"labels":{"aa":"S: A831V; nsp2: T429I","spike_mutations":"A831V"}}},{"name":"BA.1.8","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.8"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.060263156890869}},"branch_attrs":{"mutations":{"nuc":["A1G","C11455T","C23987T","C29666T"],"ORF10":["L37F"],"S":["P809S"]},"labels":{"aa":"ORF10: L37F; S: P809S","spike_mutations":"P809S"}}},{"name":"BA.1.7","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.7"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.598390579223633}},"branch_attrs":{"mutations":{"nuc":["C21T","C27686T"],"ORF7a":["S98F"]},"labels":{"aa":"ORF7a: S98F"}}},{"name":"BA.1.9","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.9"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.149862766265869}},"branch_attrs":{"mutations":{"nuc":["A1C","C21T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"NODE_0000648","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{"nuc":["G1957T"],"nsp2":["K384N"]},"labels":{"aa":"nsp2: K384N"}},"children":[{"name":"BA.1.13.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.6200740337371826}},"branch_attrs":{"mutations":{"nuc":["A3779G","G19684T"],"nsp15":["V22L"],"nsp3":["N354D"]},"labels":{"aa":"nsp15: V22L; nsp3: N354D"}}},{"name":"BA.1.13","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000649","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.447277069091797}},"branch_attrs":{"mutations":{"nuc":["G27762T"],"ORF7b":["E3*"]},"labels":{"aa":"ORF7b: E3*"}},"children":[{"name":"BA.1.21","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.447277069091797}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.21.1","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.21.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.046947002410889}},"branch_attrs":{"mutations":{"nuc":["T15685A"],"nsp12":["L749M"]},"labels":{"aa":"nsp12: L749M"}}}]},{"name":"NODE_0000650","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{"nuc":["A1C","C12786T"],"nsp9":["T34I"]},"labels":{"aa":"nsp9: T34I"}},"children":[{"name":"BA.1.14","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.14.2","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.14.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.215561866760254}},"branch_attrs":{"mutations":{"nuc":["C1812T"],"nsp2":["A336V"]},"labels":{"aa":"nsp2: A336V"}}},{"name":"BA.1.14.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.468590497970581}},"branch_attrs":{"mutations":{"nuc":["C11109T"],"nsp6":["A46V"]},"labels":{"aa":"nsp6: A46V"}}}]},{"name":"NODE_0000651","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{"nuc":["T3104C","C29632T"],"nsp3":["Y129H"]},"labels":{"aa":"nsp3: Y129H"}},"children":[{"name":"BA.1.16.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.663555145263672}},"branch_attrs":{"mutations":{"nuc":["G9758A","G25455A","T25556G"],"ORF3a":["V55G"],"nsp4":["V402I"]},"labels":{"aa":"ORF3a: V55G; nsp4: V402I"}}},{"name":"BA.1.16","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.16.2","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-5.067102432250977}},"branch_attrs":{"mutations":{"nuc":["C21T","T12436C","A28254G"],"ORF8":["I121V"]},"labels":{"aa":"ORF8: I121V"}}}]},{"name":"NODE_0000652","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{"nuc":["A1C","T10135C","C25708T","A29301G"],"N":["D343G"],"ORF3a":["L106F"]},"labels":{"aa":"N: D343G; ORF3a: L106F"}},"children":[{"name":"BA.1.15","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.15.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.538003921508789}},"branch_attrs":{"mutations":{"nuc":["A24803G"],"S":["I1081V"]},"labels":{"aa":"S: I1081V","spike_mutations":"I1081V"}}},{"name":"BA.1.15.2","node_attrs":{"div":60,"Nextclade_pango":{"value":"BA.1.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.754347085952759}},"branch_attrs":{"mutations":{"nuc":["G22520A","C23444A"],"S":["V320I","Q628K"]},"labels":{"aa":"S: V320I, Q628K","spike_mutations":"V320I, Q628K"}}},{"name":"BA.1.15.3","node_attrs":{"div":61,"Nextclade_pango":{"value":"BA.1.15.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.253582000732422}},"branch_attrs":{"mutations":{"nuc":["C21T","C3602T","C25886T"],"ORF3a":["S165F"],"nsp3":["H295Y"]},"labels":{"aa":"ORF3a: S165F; nsp3: H295Y"}}}]},{"name":"NODE_0000653","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.17"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{"nuc":["A1C","G5924A"],"nsp3":["V1069I"]},"labels":{"aa":"nsp3: V1069I"}},"children":[{"name":"BA.1.17","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.17.1","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.100675106048584}},"branch_attrs":{"mutations":{"nuc":["C21T","C4683T"],"nsp3":["A655V"]},"labels":{"aa":"nsp3: A655V"}}},{"name":"NODE_0000654","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.335338830947876}},"branch_attrs":{"mutations":{"nuc":["C1G","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}},"children":[{"name":"BA.1.17.2","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.335338830947876}},"branch_attrs":{"mutations":{}}},{"name":"BD.1","node_attrs":{"div":61,"Nextclade_pango":{"value":"BD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4503445625305176}},"branch_attrs":{"mutations":{"nuc":["C21T","C3241T","C23444A"],"S":["Q628K"]},"labels":{"aa":"S: Q628K","spike_mutations":"Q628K"}}}]}]},{"name":"NODE_0000655","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4240970611572266}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}},"children":[{"name":"BA.1.1","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4240970611572266}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.1.3","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["C4582T","C23934T","A28416G"],"N":["N48S"],"ORF9b":["I45V"],"S":["T791I"]},"labels":{"aa":"N: N48S; ORF9b: I45V; S: T791I","spike_mutations":"T791I"}}},{"name":"BA.1.1.4","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.4"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7377076148986816}},"branch_attrs":{"mutations":{"nuc":["C21T","G16744A","T25711C","C29754T"],"ORF3a":["Y107H"],"nsp13":["G170S"]},"labels":{"aa":"ORF3a: Y107H; nsp13: G170S"}}},{"name":"NODE_0000656","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.674670934677124}},"branch_attrs":{"mutations":{"nuc":["A1T","A16064G"],"nsp12":["Q875R"]},"labels":{"aa":"nsp12: Q875R"}},"children":[{"name":"BA.1.1.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.674670934677124}},"branch_attrs":{"mutations":{}}},{"name":"BC.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.36091685295105}},"branch_attrs":{"mutations":{"nuc":["C5833T","A22259G"],"S":["I233V"]},"labels":{"aa":"S: I233V","spike_mutations":"I233V"}}},{"name":"BC.2","node_attrs":{"div":60,"Nextclade_pango":{"value":"BC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.884258270263672}},"branch_attrs":{"mutations":{"nuc":["C21T","C13862T","G19348A"],"nsp12":["T141I"],"nsp14":["V437I"]},"labels":{"aa":"nsp12: T141I; nsp14: V437I"}}}]},{"name":"NODE_0000657","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.3621491193771362}},"branch_attrs":{"mutations":{"nuc":["C2470T"]}},"children":[{"name":"BA.1.1.10","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.10"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.4704771041870117}},"branch_attrs":{"mutations":{"nuc":["C21T","C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}}},{"name":"BA.1.1.11","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.11"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.2315807342529297}},"branch_attrs":{"mutations":{"nuc":["G2354A"],"nsp2":["G517R"]},"labels":{"aa":"nsp2: G517R"}}},{"name":"BA.1.1.12","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.12"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.3868720531463623}},"branch_attrs":{"mutations":{"nuc":["C21T","C2942A"],"nsp3":["L75M"]},"labels":{"aa":"nsp3: L75M"}}},{"name":"BA.1.1.14","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.8932130336761475}},"branch_attrs":{"mutations":{"nuc":["A14107G"],"nsp12":["I223V"]},"labels":{"aa":"nsp12: I223V"}}},{"name":"BA.1.1.13","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.139564037322998}},"branch_attrs":{"mutations":{"nuc":["C21T","C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"BA.1.1.16","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.8349038362503052}},"branch_attrs":{"mutations":{"nuc":["A1C","C21595T","C27509G"],"ORF7a":["T39R"]},"labels":{"aa":"ORF7a: T39R"}}},{"name":"BA.1.1.15","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.933518171310425}},"branch_attrs":{"mutations":{"nuc":["G13570A","G29755C"],"nsp12":["G44S"]},"labels":{"aa":"nsp12: G44S"}}},{"name":"BA.1.1.18","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.18"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.329127311706543}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"nsp3":["A1736V"]},"labels":{"aa":"nsp3: A1736V"}}},{"name":"BA.1.1.17","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.2085862159729}},"branch_attrs":{"mutations":{"nuc":["G1659T","C5183T"],"nsp2":["G285V"],"nsp3":["P822S"]},"labels":{"aa":"nsp2: G285V; nsp3: P822S"}}},{"name":"BA.1.1.2","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.413982391357422}},"branch_attrs":{"mutations":{"nuc":["C10560G"],"nsp5":["T169S"]},"labels":{"aa":"nsp5: T169S"}}},{"name":"BA.1.1.5","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.5"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.915313482284546}},"branch_attrs":{"mutations":{"nuc":["C21T","A2589G","C26996T"],"nsp2":["E595G"]},"labels":{"aa":"nsp2: E595G"}}},{"name":"BA.1.1.9","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.9"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.4199085235595703}},"branch_attrs":{"mutations":{"nuc":["C13421T"],"nsp10":["L133F"]},"labels":{"aa":"nsp10: L133F"}}},{"name":"BA.1.1.6","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.6"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.071193695068359}},"branch_attrs":{"mutations":{"nuc":["C21T","C5144T","C28757T"],"N":["P162S"]},"labels":{"aa":"N: P162S"}}},{"name":"BA.1.1.7","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.7"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.486417770385742}},"branch_attrs":{"mutations":{"nuc":["C2453T"],"nsp2":["L550F"]},"labels":{"aa":"nsp2: L550F"}}},{"name":"BA.1.1.8","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.8"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.9190704822540283}},"branch_attrs":{"mutations":{"nuc":["C1766A"],"nsp2":["Q321K"]},"labels":{"aa":"nsp2: Q321K"}}}]}]}]},{"name":"internal_a01b","node_attrs":{"div":51,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.760036468505859}},"branch_attrs":{"mutations":{"nuc":["T670G","G4184A","C4321T","C9534T","G10447A","T11294-","T11295-","T11296-","C12880T","C15714T","G22775A","C26060T","C26858T","A29510C","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["S413R"],"ORF3a":["T223I"],"S":["D405N"],"nsp1":["S135R"],"nsp3":["G489S"],"nsp4":["T327I"],"nsp6":["F108-"]},"labels":{"aa":"N: S413R; ORF3a: T223I; S: D405N; nsp1: S135R; nsp3: G489S; nsp4: T327I; nsp6: F108-","spike_mutations":"D405N"}},"children":[{"name":"internal_8b65","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"nsp6":["A88V"]},"labels":{"aa":"nsp6: A88V"}},"children":[{"name":"BA.3","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":44},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"BA.3.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3.1"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3791A","C3792A","A22812C"],"S":["N417T"],"nsp3":["A358N"]},"labels":{"aa":"S: N417T; nsp3: A358N","spike_mutations":"N417T"}}}]},{"name":"internal_16e4","node_attrs":{"div":70,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.930835485458374}},"branch_attrs":{"mutations":{"nuc":["C2790T","C9344T","A9424G","C10198T","C17410T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21762C","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","T21846C","-21987A","-21988T","-21989G","-21990T","-21991T","-21992T","-21993A","-21994T","-21995T","-22194A","-22195T","-22196T","T22200G","A22688G","A22786C","A22898G","C25000T","C25584T","G27382C","A27383T","T27384C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-"],"ORF6":["D61L"],"S":["T19I","L24-","P25-","P26-","A27S","V67A","-69H","-70V","I95T","-142D","-143V","-144Y","D145Y","-211N","I212L","V213G","T376A","R408S","S446G"],"nsp13":["R392C"],"nsp15":["T112I"],"nsp3":["T24I"],"nsp4":["L264F"]},"labels":{"aa":"ORF6: D61L; S: T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G; nsp13: R392C; nsp15: T112I; nsp3: T24I; nsp4: L264F","clade":"21L","spike_mutations":"T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G"}},"children":[{"name":"BA.2","node_attrs":{"div":70,"Nextclade_pango":{"value":"BA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.930835485458374}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.16","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.223683834075928}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"nsp1":["V84-","M85-"]},"labels":{"aa":"N: T296I; nsp1: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.15"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.828917503356934}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"S":["W64L"],"nsp4":["T387I"]},"labels":{"aa":"S: W64L; nsp4: T387I","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.19"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.502110004425049}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"nsp2":["T153M"]},"labels":{"aa":"nsp2: T153M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.87"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":129,"Nextclade_pango":{"value":"BA.2.87.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8217399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":41},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6657453429914796"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"],"nsp1":["Q15R","M85-","E93K"],"nsp12":["G671S","L829F"],"nsp13":["Q470K"],"nsp14":["L442S"],"nsp3":["E545D","S554A","P822L","A1526V","S1682F"],"nsp4":["T495A"],"nsp7":["L56F"],"nsp9":["K36Q","P71S"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G; nsp1: Q15R, M85-, E93K; nsp12: G671S, L829F; nsp13: Q470K; nsp14: L442S; nsp3: E545D, S554A, P822L, A1526V, S1682F; nsp4: T495A; nsp7: L56F; nsp9: K36Q, P71S","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"NODE_0000662","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-1.482762336730957}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"nsp4":["L438F"]},"labels":{"aa":"nsp4: L438F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.958613395690918}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}}},{"name":"BA.2.11","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04096000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"S":["L452R"],"nsp3":["S1701P"]},"labels":{"aa":"S: L452R; nsp3: S1701P","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.18"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.0617408752441406}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9340405464172363}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.03172000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.01261797446067892"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.24"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.043281078338623}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.26"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5770962238311768}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"nsp2":["L400F"],"nsp4":["T62I"]},"labels":{"aa":"nsp2: L400F; nsp4: T62I"}}},{"name":"BA.2.28","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.28"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.954390048980713}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF3a":["D22G"],"nsp3":["R1297S"],"nsp4":["T269I"]},"labels":{"aa":"ORF3a: D22G; nsp3: R1297S; nsp4: T269I"}}},{"name":"BA.2.27","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.27"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9474265575408936}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"nsp3":["M265I"]},"labels":{"aa":"nsp3: M265I"}}},{"name":"BA.2.29","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.29"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2460474967956543}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"nsp2":["A403T"]},"labels":{"aa":"nsp2: A403T"}}},{"name":"BA.2.30","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.30"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.186188220977783}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF3a":["E239D"],"nsp3":["H295Y"]},"labels":{"aa":"ORF3a: E239D; nsp3: H295Y"}}},{"name":"BA.2.32","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.32"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.723731756210327}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.4","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7230255603790283}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.39","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.39"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"S":["L858I"],"nsp12":["E744D"],"nsp15":["V186F","S243G"]},"labels":{"aa":"S: L858I; nsp12: E744D; nsp15: V186F, S243G","spike_mutations":"L858I"}}},{"name":"BA.2.41","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.41"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7298529148101807}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.42","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.42"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11284999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.43"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.411208152770996}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"S":["F371Y","E1202Q"],"nsp2":["Q588R"]},"labels":{"aa":"S: F371Y, E1202Q; nsp2: Q588R","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.46","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.46"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.784235954284668}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.5","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5876340866088867}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"nsp3":["P200S"]},"labels":{"aa":"nsp3: P200S"}}},{"name":"BA.2.48","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.48"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7899765968322754}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"S":["Y248S"],"nsp3":["T504I"]},"labels":{"aa":"S: Y248S; nsp3: T504I","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.50"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.211312770843506}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.54","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.54"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.137404441833496}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.55","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.55"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.214793682098389}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.58","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.58"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0507121086120605}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.61","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.61"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.497011184692383}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.59","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.59"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.60070276260376}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.60","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.60"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"S":["V1129I","P1162S"],"nsp2":["T371S"],"nsp3":["P679S"]},"labels":{"aa":"S: V1129I, P1162S; nsp2: T371S; nsp3: P679S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.62","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.62"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9947850704193115}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.64","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.64"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.5229573249816895}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"nsp6":["L98F"]},"labels":{"aa":"nsp6: L98F"}}},{"name":"BA.2.65","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.65"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.8447983264923096}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.63","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.63"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.1785149574279785}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"nsp14":["R212K"],"nsp3":["S126L"]},"labels":{"aa":"nsp14: R212K; nsp3: S126L"}}},{"name":"BA.2.70","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.70"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.472323894500732}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"nsp2":["I21V"],"nsp3":["K837N"],"nsp4":["A92T"]},"labels":{"aa":"nsp2: I21V; nsp3: K837N; nsp4: A92T"}}},{"name":"BA.2.77","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.2.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9213199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3221048136122174"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.77"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.605336666107178}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"],"nsp5":["T93I"]},"labels":{"aa":"E: L21F; M: S4F; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H; nsp5: T93I","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.82","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.82"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.82"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.216998100280762}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"S":["I68T","R346T"],"nsp10":["T58I"],"nsp8":["A63T"]},"labels":{"aa":"S: I68T, R346T; nsp10: T58I; nsp8: A63T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.8","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.326139211654663}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.83"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.12534"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.22071783986880583"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.83"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"],"nsp10":["T58I"],"nsp3":["L1328F","T1356A"],"nsp5":["P96S"]},"labels":{"aa":"E: V58L; N: K65R; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L; nsp10: T58I; nsp3: L1328F, T1356A; nsp5: P96S","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.85"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.85"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.299220561981201}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000663","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"S":["I1221T"],"nsp3":["T725I"],"nsp8":["T145I"]},"labels":{"aa":"S: I1221T; nsp3: T725I; nsp8: T145I","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000664","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.123868942260742}},"branch_attrs":{"mutations":{"nuc":["G670T"],"nsp1":["R135S"]},"labels":{"aa":"nsp1: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.123868942260742}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF9b":["N36Y"],"nsp3":["S1717L"]},"labels":{"aa":"N: Q39L; ORF9b: N36Y; nsp3: S1717L"}}}]},{"name":"internal_04a9","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"nsp7":["D77N"]},"labels":{"aa":"nsp7: D77N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.867143630981445}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000666","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.892359972000122}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.33"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.086283206939697}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"nsp3":["P395L"]},"labels":{"aa":"nsp3: P395L"}}},{"name":"BA.2.35","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04096000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.35"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.5697021484375}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.795884847640991}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"nsp15":["Q19H"]},"labels":{"aa":"nsp15: Q19H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.795884847640991}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.40.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.748093843460083}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000668","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.964897632598877}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.964897632598877}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.56.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.696688652038574}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"NODE_0000669","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.636354446411133}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"nsp13":["S36P"]},"labels":{"aa":"nsp13: S36P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.636354446411133}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.3","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.07940673828125}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.2","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.684506416320801}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.4","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.2.10.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.73328"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3166622371297313"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.095335483551025}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"],"nsp12":["G671S"]},"labels":{"aa":"ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L; nsp12: G671S","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.472019672393799}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.472019672393799}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.09519000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6181860283242497"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"],"nsp1":["K47R"],"nsp12":["G671S"]},"labels":{"aa":"M: D3Y; N: T282I; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I; nsp1: K47R; nsp12: G671S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000671","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-1.6233329772949219}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.14"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6388018131256104}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.22"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2793381214141846}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"S":["F186S"],"nsp8":["Q24H"]},"labels":{"aa":"S: F186S; nsp8: Q24H","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.34"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.040848731994629}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.36"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.0697343349456787}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.45","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.30756000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.45"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6386520862579346}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.47","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.47"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.130118370056152}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"S":["Y248H","S1261Y"],"nsp2":["L71F"]},"labels":{"aa":"S: Y248H, S1261Y; nsp2: L71F","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.49"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7807657718658447}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.51","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.51"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.694986581802368}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.52"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8800225257873535}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"nsp2":["C475R"]},"labels":{"aa":"nsp2: C475R"}}},{"name":"BA.2.53","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.33552999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.53"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.6","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6629879474639893}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.7","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.356294631958008}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"nsp3":["T1306I"]},"labels":{"aa":"nsp3: T1306I"}}},{"name":"BA.2.69","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.69"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.939220905303955}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"nsp12":["M463L"]},"labels":{"aa":"nsp12: M463L"}}},{"name":"BA.2.72","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.72"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.616490125656128}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.71","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.71"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.660243034362793}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.80","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.80"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10838000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.31190394480802347"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.80"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.6446309089660645}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"S":["R346T","K356T"],"nsp3":["N22H","R586C"]},"labels":{"aa":"S: R346T, K356T; nsp3: N22H, R586C","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.81"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.81"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.347172260284424}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"S":["L452M"],"nsp12":["I244T"]},"labels":{"aa":"S: L452M; nsp12: I244T","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"nsp2":["I283V"]},"labels":{"aa":"nsp2: I283V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.99613094329834}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"internal_8e5d","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.7391469478607178}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11284999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.44"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.218840599060059}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.024046421051025}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000675","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.191652774810791}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.191652774810791}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.2.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"S":["L452M"],"nsp2":["K142R"]},"labels":{"aa":"N: P67S, S412I; S: L452M; nsp2: K142R","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.352867364883423}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.2","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.620241165161133}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"nsp3":["T1189I"]},"labels":{"aa":"nsp3: T1189I"}}},{"name":"BA.2.9.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.9.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2389769554138184}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"nsp3":["V575A"]},"labels":{"aa":"nsp3: V575A"}}},{"name":"BA.2.9.6","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.9.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.504534721374512}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"S":["L452M"],"nsp2":["V447F"],"nsp3":["P822S"]},"labels":{"aa":"S: L452M; nsp2: V447F; nsp3: P822S","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.2.9.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"],"nsp13":["Q470R"],"nsp3":["H295Y"]},"labels":{"aa":"ORF6: L61P; ORF9b: P51L; S: S730F; nsp13: Q470R; nsp3: H295Y","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000676","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF3a":["L140F"],"nsp4":["A146V"]},"labels":{"aa":"ORF3a: L140F; nsp4: A146V"}},"children":[{"name":"BA.2.3.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.10","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0984086990356445}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.11","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7979328632354736}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"nsp10":["T101I"]},"labels":{"aa":"nsp10: T101I"}}},{"name":"BA.2.3.13","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.3481760025024414}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"nsp5":["L75F"]},"labels":{"aa":"nsp5: L75F"}}},{"name":"BA.2.3.12","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"nsp14":["L157F"],"nsp8":["T145I"]},"labels":{"aa":"nsp14: L157F; nsp8: T145I"}}},{"name":"BA.2.3.17","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.17"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8992514610290527}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"nsp12":["A97V"],"nsp2":["K618N"]},"labels":{"aa":"nsp12: A97V; nsp2: K618N"}}},{"name":"BA.2.3.15","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.15"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8729300498962402}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.19","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.3.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.19"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.702374458312988}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"],"nsp3":["C1421G"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF9b: -27E, -28N, -29A; S: N417T; nsp3: C1421G","spike_mutations":"N417T"}}},{"name":"BA.2.3.14","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.14"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.958418846130371}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"nsp4":["D459A"]},"labels":{"aa":"nsp4: D459A"}}},{"name":"BA.2.3.18","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.18"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.462870121002197}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"nsp13":["R155C","I512S"]},"labels":{"aa":"nsp13: R155C, I512S"}}},{"name":"BA.2.3.5","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3020405769348145}},"branch_attrs":{"mutations":{"nuc":["C936T"],"nsp2":["T44I"]},"labels":{"aa":"nsp2: T44I"}}},{"name":"BA.2.3.7","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"S":["K97E"],"nsp2":["L451F"]},"labels":{"aa":"N: M322I; S: K97E; nsp2: L451F","spike_mutations":"K97E"}}},{"name":"BA.2.3.4","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.8","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"nsp3":["T754I","R883S"]},"labels":{"aa":"nsp3: T754I, R883S"}}},{"name":"BA.2.3.9","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8521339893341064}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9121458530426025}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9121458530426025}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9456899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43687237373984505"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"],"nsp10":["T58I"],"nsp3":["E1271D"],"nsp5":["E47Q"]},"labels":{"aa":"M: S4F; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V; nsp10: T58I; nsp3: E1271D; nsp5: E47Q","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.601434707641602}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06758"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.828201770782471}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"DD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9683399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4733677107846063"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"],"nsp4":["A380V"]},"labels":{"aa":"S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N; nsp4: A380V","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000679","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.17149543762207}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.2.3.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.37526000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.42289430257523936"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.22"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"],"nsp13":["P529L"]},"labels":{"aa":"ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S; nsp13: P529L","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0095014572143555}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000681","node_attrs":{"div":99,"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"],"nsp1":["E10K","L122F"],"nsp13":["T61I"],"nsp2":["E546A"],"nsp3":["H682Y","I896V","K977Q","S1285F"],"nsp6":["L260F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F; nsp1: E10K, L122F; nsp13: T61I; nsp2: E546A; nsp3: H682Y, I896V, K977Q, S1285F; nsp6: L260F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"BS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66194"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-09-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.49181526572268314"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"BS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6589000000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6029918987948071"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"BS.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66821"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4975483601650658"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000682","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"],"nsp13":["T481M"],"nsp2":["T547I"],"nsp3":["I896T","M1351V","T1356I","T1830I"],"nsp7":["Q63R"]},"labels":{"aa":"ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q; nsp13: T481M; nsp2: T547I; nsp3: I896T, M1351V, T1356I, T1830I; nsp7: Q63R","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.3.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8190299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7593324873420084"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000683","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"nsp12":["D155G"]},"labels":{"aa":"nsp12: D155G"}},"children":[{"name":"CM.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91683"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7016283989012374"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":97,"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G354C"],"nsp1":["G30A"]},"labels":{"aa":"nsp1: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"CM.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"CM.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9440299999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8143059671640498"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"S":["A348S"],"nsp2":["E570G"],"nsp3":["T1251I"]},"labels":{"aa":"S: A348S; nsp2: E570G; nsp3: T1251I","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.99403"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7255583352017505"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000687","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"CM.8.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"CM.8.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF10":["A28V"],"nsp14":["N266D"]},"labels":{"aa":"ORF10: A28V; nsp14: N266D"}}},{"name":"NODE_0000688","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":104,"Nextclade_pango":{"value":"CM.8.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000689","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"S":["K147N"],"nsp13":["A52V"]},"labels":{"aa":"S: K147N; nsp13: A52V","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.28625999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0761544902802131"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"NODE_0000690","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35566999999999993"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0179803928276123"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"CM.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"S":["G485D"],"nsp6":["F184V"]},"labels":{"aa":"S: G485D; nsp6: F184V","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"nsp3":["S1285F"]},"labels":{"aa":"nsp3: S1285F"}},"children":[{"name":"CM.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000692","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"nsp15":["N82S"]},"labels":{"aa":"nsp15: N82S"}}},{"name":"NODE_0000693","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.7.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9729599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9785485534494837"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"S":["R403K"],"nsp1":["L16F","A131T"],"nsp12":["V354L"]},"labels":{"aa":"S: R403K; nsp1: L16F, A131T; nsp12: V354L","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000694","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.128854513168335}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.17"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.112544536590576}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"nsp3":["G255R"],"nsp4":["D70G"]},"labels":{"aa":"nsp3: G255R; nsp4: D70G"}}},{"name":"BA.2.37","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.37"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.100731372833252}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"nsp3":["R603K"]},"labels":{"aa":"nsp3: R603K"}}},{"name":"BA.2.57","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.57"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.165760517120361}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"nsp3":["Y1102C"]},"labels":{"aa":"nsp3: Y1102C"}}},{"name":"BA.2.66","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.66"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.677023887634277}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF10":["S23F"],"nsp2":["N133K"],"nsp3":["G334D"]},"labels":{"aa":"ORF10: S23F; nsp2: N133K; nsp3: G334D"}}},{"name":"BA.2.68","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.68"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.937255382537842}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"nsp10":["G34R"]},"labels":{"aa":"nsp10: G34R"}}},{"name":"BA.2.74","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21698000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.33134042675697756"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.74"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8886806964874268}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.73","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.73"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0411696434021}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"S":["G257S"],"nsp3":["P1469S"]},"labels":{"aa":"S: G257S; nsp3: P1469S","spike_mutations":"G257S"}}},{"name":"BA.2.78","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.78"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.664361953735352}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF10":["R24L"],"S":["L452M"],"nsp5":["K90R"]},"labels":{"aa":"ORF10: R24L; S: L452M; nsp5: K90R","spike_mutations":"L452M"}}},{"name":"NODE_0000695","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.096076011657715}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.67"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"nsp10":["D64E"]},"labels":{"aa":"nsp10: D64E"}}},{"name":"NODE_0000696","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"S":["Y248S","N450D"],"nsp13":["P53S"]},"labels":{"aa":"S: Y248S, N450D; nsp13: P53S","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.058580000000000014"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.79.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.058580000000000014"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"nsp13":["I493V"],"nsp3":["T1198I"]},"labels":{"aa":"nsp13: I493V; nsp3: T1198I"}}}]}]},{"name":"NODE_0000697","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000698","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"nsp15":["V22L"]},"labels":{"aa":"nsp15: V22L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.76.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"S":["N185H"],"nsp6":["A161T"]},"labels":{"aa":"S: N185H; nsp6: A161T","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.76.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18492"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.2640232066165751"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"S":["R357K"],"nsp3":["G777S"]},"labels":{"aa":"S: R357K; nsp3: G777S","spike_mutations":"R357K"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.4447851181030273}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.4447851181030273}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.38.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.08445999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.07383293656037815"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":82,"Nextclade_pango":{"value":"BH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.11188000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.370455061085298"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.580877304077148}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"S":["Y144-","G446S","L452Q"],"nsp3":["F396I"],"nsp5":["A94G"]},"labels":{"aa":"S: Y144-, G446S, L452Q; nsp3: F396I; nsp5: A94G","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000701","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.987913131713867}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0862932205200195}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000702","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.91279411315918}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.4","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.38.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.449609756469727}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}},{"name":"BA.2.38.2","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.38.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"S":["F157S"],"nsp10":["T102I"],"nsp3":["T725I"],"nsp6":["N156S"]},"labels":{"aa":"S: F157S; nsp10: T102I; nsp3: T725I; nsp6: N156S","spike_mutations":"F157S"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.12.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07350000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.062348652344665065"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"22C","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0579047203063965}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0579047203063965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000705","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-1.8292839527130127}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"nsp12":["A923T"],"nsp3":["N1247D"]},"labels":{"aa":"nsp12: A923T; nsp3: N1247D"}}},{"name":"BG.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.2"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"],"nsp6":["F184V"]},"labels":{"aa":"N: T282I; ORF7b: A15S; ORF8: Q18*; S: V1264L; nsp6: F184V","spike_mutations":"V1264L"}}},{"name":"BG.3","node_attrs":{"div":79,"Nextclade_pango":{"value":"BG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.3"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.567026138305664}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"nsp4":["T204A"]},"labels":{"aa":"nsp4: T204A"}}},{"name":"BG.5","node_attrs":{"div":79,"Nextclade_pango":{"value":"BG.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.5"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"nsp8":["D30G"]},"labels":{"aa":"nsp8: D30G"}}},{"name":"BG.6","node_attrs":{"div":80,"Nextclade_pango":{"value":"BG.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.6"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"S":["E1202Q"],"nsp10":["V13I"]},"labels":{"aa":"S: E1202Q; nsp10: V13I","spike_mutations":"E1202Q"}}},{"name":"BG.4","node_attrs":{"div":82,"Nextclade_pango":{"value":"BG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.4"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"nsp13":["L581F"],"nsp3":["I1460T"]},"labels":{"aa":"N: P162L; nsp13: L581F; nsp3: I1460T"}}},{"name":"BG.7","node_attrs":{"div":84,"Nextclade_pango":{"value":"BG.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.7"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"nsp2":["E546K"],"nsp3":["V202A","F814L","F1503L"]},"labels":{"aa":"nsp2: E546K; nsp3: V202A, F814L, F1503L"}}}]}]}]},{"name":"NODE_0000706","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"],"nsp12":["G671S"],"nsp3":["S403L","P822S"],"nsp8":["N118S"]},"labels":{"aa":"E: T11A; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q; nsp12: G671S; nsp3: S403L, P822S; nsp8: N118S","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.2.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.499693393707275}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"nsp8":["T17A"]},"labels":{"aa":"nsp8: T17A"}}},{"name":"BA.2.75.8","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.75.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04854"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"S":["L452Q"],"nsp12":["K508R"],"nsp2":["V244A"],"nsp3":["R352H"]},"labels":{"aa":"S: L452Q; nsp12: K508R; nsp2: V244A; nsp3: R352H","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.544774532318115}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81858"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.514627933502197}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.472270488739014}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.2.75.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13451"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.472270488739014}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000709","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7472099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7472099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.378986358642578}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.24593"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5588825437629772"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"S":["R346T"],"nsp12":["T20A"]},"labels":{"aa":"S: R346T; nsp12: T20A","spike_mutations":"R346T"}}},{"name":"NODE_0000711","node_attrs":{"div":94,"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9449499999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.12575999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7451886007636047"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"S":["F486S"],"nsp15":["F329L"]},"labels":{"aa":"S: F486S; nsp15: F329L","spike_mutations":"F486S"}}},{"name":"BR.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9449499999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}}]},{"name":"NODE_0000712","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.10514"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5013910005227346"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000713","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"S":["D574V"],"nsp8":["K72R"]},"labels":{"aa":"S: D574V; nsp8: K72R","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03573"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"BR.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03573"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"nsp13":["T599I"],"nsp3":["K1211N"]},"labels":{"aa":"nsp13: T599I; nsp3: K1211N"}}}]}]}]}]},{"name":"NODE_0000714","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000715","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.210728645324707}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"nsp3":["P1867S"]},"labels":{"aa":"nsp3: P1867S"}}},{"name":"BL.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BL.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16854"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF8":["L4F"],"S":["R346S"],"nsp14":["R135I"]},"labels":{"aa":"N: P368S; ORF8: L4F; S: R346S; nsp14: R135I","spike_mutations":"R346S"}}},{"name":"NODE_0000716","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"S":["K182E"],"nsp12":["H613Y"]},"labels":{"aa":"S: K182E; nsp12: H613Y","spike_mutations":"K182E"}}},{"name":"BL.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000717","node_attrs":{"div":90,"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.19193"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"S":["F490L"],"nsp16":["P215L","R216N"]},"labels":{"aa":"S: F490L; nsp16: P215L, R216N","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BL.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.3464399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF7b":["S31P"],"S":["F490V"],"nsp13":["R507K"]},"labels":{"aa":"ORF7b: S31P; S: F490V; nsp13: R507K","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.56756"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6011952983295785"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"BL.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.11979"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5544855553668998"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF10":["A28V"],"S":["V445A"],"nsp3":["L312F"]},"labels":{"aa":"ORF10: A28V; S: V445A; nsp3: L312F","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.681194305419922}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.681194305419922}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":91,"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"S":["N185D","H207R"],"nsp2":["I77V"],"nsp4":["K8R","A149S"]},"labels":{"aa":"S: N185D, H207R; nsp2: I77V; nsp4: K8R, A149S","spike_mutations":"N185D, H207R"}}},{"name":"BY.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_147e","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BY.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41646999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["S494P"],"nsp1":["G101V"],"nsp9":["G38S"]},"labels":{"aa":"S: S494P; nsp1: G101V; nsp9: G38S","spike_mutations":"S494P"}}},{"name":"BY.1.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a555","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF3a":["G44R"],"S":["L452R","T604I"],"nsp3":["S69F","S1206L"]},"labels":{"aa":"ORF3a: G44R; S: L452R, T604I; nsp3: S69F, S1206L","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41646999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.716528415679932}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"CA.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"S":["L452R"],"nsp6":["L207I"]},"labels":{"aa":"S: L452R; nsp6: L207I","spike_mutations":"L452R"}}},{"name":"CA.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"nsp2":["Y16H"]},"labels":{"aa":"nsp2: Y16H"}}},{"name":"CA.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"CA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"S":["S486P"],"nsp2":["G339S"],"nsp3":["E177D","S1571L"]},"labels":{"aa":"S: S486P; nsp2: G339S; nsp3: E177D, S1571L","spike_mutations":"S486P"}}},{"name":"internal_80b8","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2371799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.0969929695129395}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.0969929695129395}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":91,"Nextclade_pango":{"value":"BN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14197"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78438138961792}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"S":["F490S"],"nsp2":["G212D"]},"labels":{"aa":"S: F490S; nsp2: G212D","spike_mutations":"F490S"}}},{"name":"BN.5","node_attrs":{"div":90,"Nextclade_pango":{"value":"BN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"nsp4":["V192M"]},"labels":{"aa":"nsp4: V192M"}}},{"name":"BN.6","node_attrs":{"div":91,"Nextclade_pango":{"value":"BN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"nsp8":["T17A"]},"labels":{"aa":"nsp8: T17A"}}},{"name":"internal_ece3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"S":["N450D"],"nsp16":["T140I"],"nsp2":["G212D","I387V"]},"labels":{"aa":"S: N450D; nsp16: T140I; nsp2: G212D, I387V","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.11385"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5060716304521155"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.653690335850791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"S":["F490S"],"nsp3":["K1042R"],"nsp4":["L15F"]},"labels":{"aa":"S: F490S; nsp3: K1042R; nsp4: L15F","spike_mutations":"F490S"}}}]},{"name":"internal_40f9","node_attrs":{"div":92,"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14197"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"NODE_0000727","node_attrs":{"div":93,"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"S":["L176F","D936H"],"nsp3":["L1328F"]},"labels":{"aa":"S: L176F, D936H; nsp3: L1328F","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.7","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5340599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9193315170816834"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"NODE_0000728","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.2021600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.2021600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000729","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"nsp16":["G39D"],"nsp3":["S1285F"]},"labels":{"aa":"nsp16: G39D; nsp3: S1285F"}},"children":[{"name":"BN.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000730","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"BN.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.31233"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7815531080803261"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}},{"name":"BN.1.5.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1331"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7470314258752732"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]}]},{"name":"NODE_0000731","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"nsp1":["M85-"],"nsp13":["V226L"],"nsp14":["V199M"]},"labels":{"aa":"nsp1: M85-; nsp13: V226L; nsp14: V199M"}}},{"name":"BN.1.4.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"BN.1.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"nsp5":["T24I"]},"labels":{"aa":"nsp5: T24I"}}},{"name":"NODE_0000732","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"nsp12":["T293I"],"nsp5":["V104I"]},"labels":{"aa":"nsp12: T293I; nsp5: V104I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"BN.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"],"nsp9":["T35I"]},"labels":{"aa":"ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I; nsp9: T35I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"nsp3":["P278T"]},"labels":{"aa":"nsp3: P278T"}}},{"name":"BN.1.4.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"S":["Q1113K"],"nsp15":["T48I"],"nsp16":["K160R"]},"labels":{"aa":"M: T30I; S: Q1113K; nsp15: T48I; nsp16: K160R","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000733","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.13617467880249}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.220160961151123}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000734","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.21326"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7326886306518271"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"S":["T470N"],"nsp14":["K147I"]},"labels":{"aa":"S: T470N; nsp14: K147I","spike_mutations":"T470N"}}},{"name":"BN.1.2.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"nsp14":["D222H"]},"labels":{"aa":"nsp14: D222H"}}},{"name":"BN.1.2.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"nsp13":["A403S"]},"labels":{"aa":"nsp13: A403S"}}},{"name":"BN.1.2.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000735","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"nsp14":["I275S"],"nsp3":["Y1102H"]},"labels":{"aa":"nsp14: I275S; nsp3: Y1102H"}}},{"name":"NODE_0000736","node_attrs":{"div":101,"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"S":["R190M"],"nsp13":["T250A"]},"labels":{"aa":"S: R190M; nsp13: T250A","spike_mutations":"R190M"}}},{"name":"FR.1.5","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"nsp1":["V116M"],"nsp3":["S1424F"],"nsp8":["M129T"]},"labels":{"aa":"nsp1: V116M; nsp3: S1424F; nsp8: M129T"}}},{"name":"FR.1.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"FR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF9b":["G31R"],"nsp12":["A526V"],"nsp2":["A26V"]},"labels":{"aa":"N: -31E, G34-; ORF9b: G31R; nsp12: A526V; nsp2: A26V"}}},{"name":"NODE_0000737","node_attrs":{"div":105,"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"nsp2":["L113F"]},"labels":{"aa":"nsp2: L113F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF3a":["T229I"],"nsp6":["M58I"]},"labels":{"aa":"ORF3a: T229I; nsp6: M58I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497981071472168}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"nsp5":["F223L"]},"labels":{"aa":"nsp5: F223L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{}}},{"name":"DS.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"DS.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"DS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF10":["R24C"],"S":["T572I"],"nsp14":["H26Y"]},"labels":{"aa":"ORF10: R24C; S: T572I; nsp14: H26Y","spike_mutations":"T572I"}}},{"name":"DS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"DS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16291"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0513083167390975"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"nsp1":["H110Y"]},"labels":{"aa":"nsp1: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"nsp3":["Q1100R"]},"labels":{"aa":"nsp3: Q1100R"}}},{"name":"BN.1.3.12","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"S":["V445A"],"nsp14":["L259R"]},"labels":{"aa":"S: V445A; nsp14: L259R","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}},{"name":"EJ.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"EJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"nsp10":["T102I"]},"labels":{"aa":"nsp10: T102I"}}}]},{"name":"internal_f14e","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.269749402999878}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":102,"Nextclade_pango":{"value":"BN.1.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"nsp2":["T388I"],"nsp3":["V393F"]},"labels":{"aa":"nsp2: T388I; nsp3: V393F"}}},{"name":"BN.1.3.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.880107879638672}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"nsp3":["T611I"]},"labels":{"aa":"nsp3: T611I"}}}]}]}]}]}]},{"name":"internal_4ad3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"nsp14":["V182I"]},"labels":{"aa":"nsp14: V182I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"nsp14":["P128S"]},"labels":{"aa":"nsp14: P128S"}}},{"name":"BM.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15852"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.03087854385376}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":96,"Nextclade_pango":{"value":"BM.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15852"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"S":["G75V","L455S"],"nsp4":["D38G"]},"labels":{"aa":"N: L113I; S: G75V, L455S; nsp4: D38G","spike_mutations":"G75V, L455S"}}},{"name":"NODE_0000745","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BM.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.26994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5272935807019111"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"S":["L455S"],"nsp3":["L1035F"]},"labels":{"aa":"S: L455S; nsp3: L1035F","spike_mutations":"L455S"}}},{"name":"NODE_0000746","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78817"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}},{"name":"BM.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81858"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000749","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BM.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"S":["T883I","S939F","P1079T"],"nsp1":["R124C"],"nsp2":["S196L"],"nsp4":["F101L"]},"labels":{"aa":"S: T883I, S939F, P1079T; nsp1: R124C; nsp2: S196L; nsp4: F101L","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"BM.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.992039680480957}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.43724"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":95,"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000752","node_attrs":{"div":96,"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"nsp3":["T763A"]},"labels":{"aa":"nsp3: T763A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.87567"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9457248359372292"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"nsp3":["L1791F"]},"labels":{"aa":"nsp3: L1791F"}}}]},{"name":"NODE_0000753","node_attrs":{"div":98,"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"CJ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CJ.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"S":["D936H"],"nsp6":["F216L"]},"labels":{"aa":"S: D936H; nsp6: F216L","spike_mutations":"D936H"}}},{"name":"CJ.1.3.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CJ.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"S":["R214S"],"nsp6":["G9S"]},"labels":{"aa":"S: R214S; nsp6: G9S","spike_mutations":"R214S"}}}]}]}]},{"name":"NODE_0000754","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000755","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"],"ORF10":["A8V"]},"labels":{"aa":"ORF10: A8V"}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"S":["S486P"],"nsp13":["Y224C"],"nsp2":["G334E"]},"labels":{"aa":"S: S486P; nsp13: Y224C; nsp2: G334E","spike_mutations":"S486P"}}},{"name":"CV.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"S":["L452R"],"nsp3":["V732A"]},"labels":{"aa":"S: L452R; nsp3: V732A","spike_mutations":"L452R"}}}]},{"name":"NODE_0000756","node_attrs":{"div":97,"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"S":["K356T","T572I"],"nsp2":["S36Y","D449A"]},"labels":{"aa":"S: K356T, T572I; nsp2: S36Y, D449A","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"BM.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.46466000000000013"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000757","node_attrs":{"div":99,"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"EP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.46466000000000013"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000758","node_attrs":{"div":105,"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"S":["L452R"],"nsp16":["V9I"]},"labels":{"aa":"S: L452R; nsp16: V9I","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"EP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":109,"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF8":["Q18H"],"nsp8":["P178S"]},"labels":{"aa":"ORF8: Q18H; nsp8: P178S"}},"children":[{"name":"EP.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"EP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"EP.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"ORF10":["R24H"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"ORF10: R24H; S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"nsp3":["Q380K"]},"labels":{"aa":"nsp3: Q380K"}},"children":[{"name":"BM.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000763","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.852805137634277}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"nsp16":["Q28R"]},"labels":{"aa":"nsp16: Q28R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0219999999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":94,"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"CH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36891999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7685109779549473"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000766","node_attrs":{"div":95,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CH.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"nsp2":["S358L"]},"labels":{"aa":"nsp2: S358L"}}},{"name":"CH.1.1.7","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"nsp1":["F143C"]},"labels":{"aa":"nsp1: F143C"}}},{"name":"NODE_0000767","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"S":["K187T"],"nsp2":["M404V"],"nsp3":["A256V"]},"labels":{"aa":"N: A155V; S: K187T; nsp2: M404V; nsp3: A256V","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.08511000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7a:59-122"},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.9441222497200389"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF7a":["C58-"],"S":["N481Y"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: C58-; S: N481Y; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000768","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000769","node_attrs":{"div":101,"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"S":["S486P"],"nsp13":["V597L"],"nsp3":["H727Q"]},"labels":{"aa":"S: S486P; nsp13: V597L; nsp3: H727Q","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9334899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9334899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF7a":["H47N"],"S":["G213E"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp12":["T248I"],"nsp4":["I492T"]},"labels":{"aa":"ORF7a: H47N; S: G213E; nsp1: G82-, H83-, V84-, M85V; nsp12: T248I; nsp4: I492T","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000770","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.513967990875244}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"nsp2":["G262S"]},"labels":{"aa":"nsp2: G262S"}}},{"name":"CH.1.1.15","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"S":["T883I"],"nsp3":["Y1028C","G1476S"]},"labels":{"aa":"S: T883I; nsp3: Y1028C, G1476S","spike_mutations":"T883I"}}},{"name":"CH.1.1.24","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.25","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"nsp2":["S150L"],"nsp9":["P57S"]},"labels":{"aa":"nsp2: S150L; nsp9: P57S"}}},{"name":"CH.1.1.29","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"S":["Q613H"],"nsp2":["P191S"]},"labels":{"aa":"S: Q613H; nsp2: P191S","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000771","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"S":["N185D"],"nsp15":["K89R"],"nsp2":["A247V"]},"labels":{"aa":"S: N185D; nsp15: K89R; nsp2: A247V","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"DV.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"internal_ddb1","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"S":["Q613H"],"nsp1":["R24C"]},"labels":{"aa":"S: Q613H; nsp1: R24C","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"nsp2":["E197K"]},"labels":{"aa":"nsp2: E197K"}},"children":[{"name":"DV.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"nsp12":["V848I"]},"labels":{"aa":"nsp12: V848I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"DV.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"nsp13":["T599I"]},"labels":{"aa":"nsp13: T599I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"S":["L858I"],"nsp5":["A285V"]},"labels":{"aa":"S: L858I; nsp5: A285V","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":108,"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF3a":["A72T"],"nsp12":["A529V"]},"labels":{"aa":"ORF3a: A72T; nsp12: A529V"}},"children":[{"name":"DV.7.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"DV.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000779","node_attrs":{"div":110,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"S":["T961M"],"nsp3":["D1764G"],"nsp8":["P10S"]},"labels":{"aa":"S: T961M; nsp3: D1764G; nsp8: P10S","spike_mutations":"T961M"}}},{"name":"NODE_0000780","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":116,"Nextclade_pango":{"value":"DV.7.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":117,"Nextclade_pango":{"value":"DV.7.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"S":["V90I"],"nsp2":["T486N"],"nsp3":["H290Y"]},"labels":{"aa":"S: V90I; nsp2: T486N; nsp3: H290Y","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF10":["M1V"],"nsp9":["A22V"]},"labels":{"aa":"ORF10: M1V; nsp9: A22V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":114,"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"nsp3":["S1428L"]},"labels":{"aa":"nsp3: S1428L"}},"children":[{"name":"JV.2","node_attrs":{"div":118,"Nextclade_pango":{"value":"JV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"S":["V772I"],"nsp2":["A510V"]},"labels":{"aa":"S: V772I; nsp2: A510V","spike_mutations":"V772I"}}},{"name":"JV.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"JV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.9432199999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}}]}]},{"name":"NODE_0000783","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"KG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":119,"Nextclade_pango":{"value":"KG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.9432199999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"S":["H49Y","A264D","G485R"],"nsp1":["S100N"],"nsp3":["D879E"]},"labels":{"aa":"S: H49Y, A264D, G485R; nsp1: S100N; nsp3: D879E","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000784","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"DV.7.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.3","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":112,"Nextclade_pango":{"value":"DV.7.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000785","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF7b":["I26S"],"nsp13":["V169F"]},"labels":{"aa":"ORF7b: I26S; nsp13: V169F"}}},{"name":"CH.1.1.32","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF9b":["Q77K"],"S":["L858I"],"nsp3":["E156A"]},"labels":{"aa":"N: P80Q; ORF9b: Q77K; S: L858I; nsp3: E156A","spike_mutations":"L858I"}}},{"name":"NODE_0000786","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000787","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"nsp3":["A358T"]},"labels":{"aa":"nsp3: A358T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000788","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.320462703704834}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":104,"Nextclade_pango":{"value":"CH.1.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF10":["I4V"],"S":["T299I","R403K","D1165G"],"nsp2":["A518T"]},"labels":{"aa":"ORF10: I4V; S: T299I, R403K, D1165G; nsp2: A518T","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF6":["K23I"],"S":["K679R"],"nsp4":["A87V"]},"labels":{"aa":"ORF6: K23I; S: K679R; nsp4: A87V","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"nsp4":["Y205H"]},"labels":{"aa":"nsp4: Y205H"}}},{"name":"CH.1.1.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"S":["T732I"],"nsp2":["K158R"],"nsp3":["P968L"]},"labels":{"aa":"S: T732I; nsp2: K158R; nsp3: P968L","spike_mutations":"T732I"}}},{"name":"CH.1.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000789","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"S":["L858I"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp2":["A306V"]},"labels":{"aa":"S: L858I; nsp1: G82-, H83-, V84-, M85V; nsp2: A306V","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"nsp8":["Q24R"]},"labels":{"aa":"nsp8: Q24R"}}}]},{"name":"NODE_0000790","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF6":["I26V"],"nsp3":["A386V"]},"labels":{"aa":"ORF6: I26V; nsp3: A386V"}}}]},{"name":"NODE_0000791","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"nsp13":["D101N"],"nsp2":["N413S"],"nsp3":["P679S"],"nsp4":["T28I"]},"labels":{"aa":"nsp13: D101N; nsp2: N413S; nsp3: P679S; nsp4: T28I"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":108,"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp3":["G1447D"]},"labels":{"aa":"ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K; nsp1: G82-, H83-, V84-, M85-, V86-; nsp3: G1447D","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"JP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:62-122"},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"JP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:62-122"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"],"nsp3":["T724I"]},"labels":{"aa":"ORF3a: P274S; ORF6: L61H; S: G1219V; nsp3: T724I","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000794","node_attrs":{"div":102,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"S":["D215G","Q613H"],"nsp6":["L260F"]},"labels":{"aa":"S: D215G, Q613H; nsp6: L260F","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":105,"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"nsp2":["L204F","R370H"]},"labels":{"aa":"nsp2: L204F, R370H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"FK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"nsp3":["T73I"]},"labels":{"aa":"nsp3: T73I"}}},{"name":"FK.1.2.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF3a":["T64N"],"nsp1":["D139N"],"nsp2":["R46K","Q376K"]},"labels":{"aa":"ORF3a: T64N; nsp1: D139N; nsp2: R46K, Q376K"}}}]},{"name":"NODE_0000796","node_attrs":{"div":103,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"S":["G181A"],"nsp6":["M183I"]},"labels":{"aa":"S: G181A; nsp6: M183I","spike_mutations":"G181A"}}}]},{"name":"NODE_0000798","node_attrs":{"div":107,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF9b":["G31R"],"nsp16":["L183I"]},"labels":{"aa":"N: -31E, G34-; ORF9b: G31R; nsp16: L183I"}},"children":[{"name":"FK.1.5","node_attrs":{"div":109,"Nextclade_pango":{"value":"FK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"NODE_0000799","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"nsp3":["A242T"]},"labels":{"aa":"nsp3: A242T"}},"children":[{"name":"FK.1.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"FK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.16085999999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9815994835819151"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"S":["V445A"],"nsp3":["A534V"]},"labels":{"aa":"S: V445A; nsp3: A534V","spike_mutations":"V445A"}}},{"name":"FK.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["T241-","C3874T","G18984A","G26888A"],"nsp14":["M315I"]},"labels":{"aa":"nsp14: M315I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["-241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"FK.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000801","node_attrs":{"div":113,"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"FK.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"JL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000802","node_attrs":{"div":120,"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.651820659637451}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"],"nsp2":["A31D"],"nsp3":["V238L","N1708S","A1892T"],"nsp6":["V24F"],"nsp9":["T35I"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L; nsp2: A31D; nsp3: V238L, N1708S, A1892T; nsp6: V24F; nsp9: T35I","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":120,"Nextclade_pango":{"value":"BA.2.86"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.651820659637451}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":121,"Nextclade_pango":{"value":"BA.2.86.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.6","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}}},{"name":"BA.2.86.5","node_attrs":{"div":125,"Nextclade_pango":{"value":"BA.2.86.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"BA.2.86.4","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"S":["A222V"],"nsp7":["V33A"]},"labels":{"aa":"S: A222V; nsp7: V33A","spike_mutations":"A222V"}}},{"name":"LV.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"LV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T","G14347A"],"nsp12":["D303N"]},"labels":{"aa":"nsp12: D303N"}}},{"name":"LV.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T21C","C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"S":["R346T","L455S","F456L"],"nsp1":["E148G"],"nsp12":["A529V"],"nsp2":["W450C"],"nsp3":["G251R"],"nsp5":["G283D"]},"labels":{"aa":"S: R346T, L455S, F456L; nsp1: E148G; nsp12: A529V; nsp2: W450C; nsp3: G251R; nsp5: G283D","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000803","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"nsp13":["Y421H"]},"labels":{"aa":"nsp13: Y421H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000804","node_attrs":{"div":128,"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":128,"Nextclade_pango":{"value":"MP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"MP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.12555999999999995"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.6738025507980547"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000805","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000806","node_attrs":{"div":126,"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":126,"Nextclade_pango":{"value":"JQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15919"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000807","node_attrs":{"div":130,"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"S":["L455S"],"nsp6":["L142F"]},"labels":{"aa":"S: L455S; nsp6: L142F","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JQ.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"JQ.2.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"S":["T572I"],"nsp12":["Q822H"],"nsp13":["L581F"]},"labels":{"aa":"S: T572I; nsp12: Q822H; nsp13: L581F","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JQ.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF3a":["I123T"],"S":["F456L"],"nsp2":["T85I"]},"labels":{"aa":"ORF3a: I123T; S: F456L; nsp2: T85I","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000808","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.782770156860352}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"nsp3":["K1155R"]},"labels":{"aa":"nsp3: K1155R"}},"children":[{"name":"JN.4","node_attrs":{"div":123,"Nextclade_pango":{"value":"JN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.51897668838501}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000809","node_attrs":{"div":123,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.825653314590454}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"BA.2.86.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.825653314590454}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.12"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"S":["F456V"],"nsp2":["A318G"]},"labels":{"aa":"S: F456V; nsp2: A318G","spike_mutations":"F456V"}}},{"name":"JN.14","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.14"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.16","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.16"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.18","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.18"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.15","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.15"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.19","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.19"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.17","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.17"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.6","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.6"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.9"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.700376033782959}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.8","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.8"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"NODE_0000810","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.11","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000811","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000812","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6465599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000813","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"nsp3":["T1269I"]},"labels":{"aa":"nsp3: T1269I"}},"children":[{"name":"JN.3.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.3","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000814","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"nsp3":["P74S"]},"labels":{"aa":"N: H300Y; nsp3: P74S"}},"children":[{"name":"JN.3.2","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]}]},{"name":"internal_59b29264","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"nsp2":["Y441C"]},"labels":{"aa":"nsp2: Y441C"}},"children":[{"name":"JN.2","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.5","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.2.4","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"NODE_0000816","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"S":["T572I"],"nsp6":["L75F"]},"labels":{"aa":"N: G25C; S: T572I; nsp6: L75F","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"S":["N487D"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"S: N487D; nsp1: G82-, H83-, V84-, M85V","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000817","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.369624137878418}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.10"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.502436637878418}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000818","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.787649631500244}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF7b":["F19L"],"S":["L455S"],"nsp6":["R252K"]},"labels":{"aa":"ORF7b: F19L; S: L455S; nsp6: R252K","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.787649631500244}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.408924102783203}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26806999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.2179484367370605}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.394025802612305}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9045872688293457}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.21","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.875349044799805}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.20","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062768936157227}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.22","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.6741955280303955}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"nsp2":["S325F"]},"labels":{"aa":"nsp2: S325F"}}},{"name":"JN.1.28","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.404186248779297}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}}},{"name":"JN.1.3","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.493562698364258}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.485931396484375}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.403597354888916}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.030079364776611}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.46","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.232482433319092}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"nsp4":["L353F"]},"labels":{"aa":"nsp4: L353F"}}},{"name":"JN.1.45","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.296973705291748}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.5","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.8042540550231934}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"nsp13":["V348T"]},"labels":{"aa":"nsp13: V348T"}}},{"name":"JN.1.52","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.117435932159424}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}}},{"name":"JN.1.61","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93036"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.496607246855186"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.40602445602417}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.62","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.60","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.340050220489502}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.66","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"],"nsp3":["L1328F","T1465I"]},"labels":{"aa":"ORF3a: L106F; S: H445P, F456L, T1117I; nsp3: L1328F, T1465I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.1086554527282715}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"S":["M1229I"],"nsp16":["T91M"]},"labels":{"aa":"S: M1229I; nsp16: T91M","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.971951484680176}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.1086554527282715}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.240773677825928}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"S":["K444R","Y453F"],"nsp2":["A127V"],"nsp3":["P1326L"]},"labels":{"aa":"S: K444R, Y453F; nsp2: A127V; nsp3: P1326L","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.21099"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.240773677825928}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.23.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.21099"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"S":["N137K","V1264L"],"nsp3":["L312F"]},"labels":{"aa":"S: N137K, V1264L; nsp3: L312F","spike_mutations":"N137K, V1264L"}}}]},{"name":"internal_f571b810","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.012888431549072}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.012888431549072}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.24.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3227362632751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.161813735961914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.261450290679932}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"JN.1.32","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.161813735961914}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_613b5275","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.844100475311279}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"nsp14":["R212K"]},"labels":{"aa":"nsp14: R212K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.844100475311279}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.39068078994751}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.39068078994751}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.741299152374268}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.741299152374268}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.44.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.847970962524414}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.473522663116455}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.54.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.05681999999999991"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.532734695870142"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"S":["V407I","F456L"],"nsp3":["D1242N","M1278T"]},"labels":{"aa":"S: V407I, F456L; nsp3: D1242N, M1278T","spike_mutations":"V407I, F456L"}}},{"name":"JN.1.54","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.473522663116455}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.906276226043701}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.56.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7602899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5395016697354735"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"S":["G181R","R346T","F456V","K484E"],"nsp3":["T820I"]},"labels":{"aa":"S: G181R, R346T, F456V, K484E; nsp3: T820I","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.906276226043701}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.803280353546143}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"nsp3":["A386S"]},"labels":{"aa":"nsp3: A386S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.803280353546143}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.59.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":8.507},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"S":["S31-","R190S","R346T"],"nsp3":["I23V"]},"labels":{"aa":"S: S31-, R190S, R346T; nsp3: I23V","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.234124660491943}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.234124660491943}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.492287635803223}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000830","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.16524600982666}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"nsp12":["K91R"]},"labels":{"aa":"nsp12: K91R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.16524600982666}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.63.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.744444847106934}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"nsp3":["D695E","A1711S"]},"labels":{"aa":"nsp3: D695E, A1711S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.0482683181762695}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.0482683181762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.25026273727417}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.25026273727417}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"S":["F456L"],"nsp12":["T248I"]},"labels":{"aa":"S: F456L; nsp12: T248I","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.394768238067627}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"nsp4":["T461A"]},"labels":{"aa":"nsp4: T461A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.394768238067627}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.341370582580566}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.29.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.341370582580566}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF8":["I121-"],"S":["S31P","R346T"],"nsp3":["E1252K"]},"labels":{"aa":"ORF8: I121-; S: S31P, R346T; nsp3: E1252K","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4552714824676514}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.332234859466553}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.332234859466553}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.36.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.063130855560303}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005667686462402}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005667686462402}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.47.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"S":["T572I","R683Q"],"nsp2":["H194Y"]},"labels":{"aa":"S: T572I, R683Q; nsp2: H194Y","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.47.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.993497371673584}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.403688907623291}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.403688907623291}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.081462383270264}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.51.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.081462383270264}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.513101100921631}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"nsp2":["K219R"]},"labels":{"aa":"nsp2: K219R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.513101100921631}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.7709059715271}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.55.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.627852916717529}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"nsp15":["P270H"]},"labels":{"aa":"nsp15: P270H"}}},{"name":"JN.1.55.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.55.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"nsp3":["T199I"]},"labels":{"aa":"nsp3: T199I"}}}]}]},{"name":"NODE_0000842","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.695337772369385}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.695337772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000843","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.67.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"2-3 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.898660898208618}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.898660898208618}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.853456020355225}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF3a":["V80A"],"S":["R346T","F456L"],"nsp16":["L126F"]},"labels":{"aa":"ORF3a: V80A; S: R346T, F456L; nsp16: L126F","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.175326347351074}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.39.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.5633111000061035}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.39.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.965564727783203}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.965564727783203}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.302712917327881}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.439761161804199}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.439761161804199}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"MS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.217731475830078}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp3":["E122G"]},"labels":{"aa":"S: S31-; nsp3: E122G","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.50.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"nsp3":["N722S"]},"labels":{"aa":"nsp3: N722S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.50.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"ME.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.27215999999999985"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.891237735748291}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.891237735748291}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.83420991897583}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.53.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.83420991897583}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000852","node_attrs":{"div":132,"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2595099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF3a":["L85F"],"S":["T572I"],"nsp3":["T1334I"]},"labels":{"aa":"ORF3a: L85F; S: T572I; nsp3: T1334I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.65.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":140,"Nextclade_pango":{"value":"MF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"S":["S60P","W64L"],"nsp15":["S288F"]},"labels":{"aa":"S: S60P, W64L; nsp15: S288F","spike_mutations":"S60P, W64L"}}}]}]},{"name":"NODE_0000855","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24034T","C24370T","A29700G"],"nsp3":["P822L"]},"labels":{"aa":"nsp3: P822L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.28.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000856","node_attrs":{"div":135,"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9318500000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3745641202332524"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000857","node_attrs":{"div":137,"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"S":["F456L"],"nsp14":["R485K"]},"labels":{"aa":"S: F456L; nsp14: R485K","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000858","node_attrs":{"div":138,"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"KW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"LG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_21507594","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.34359073638916}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.34359073638916}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000860","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.548327922821045}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.30.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.548327922821045}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.693402290344238}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":133,"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.124417304992676}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF7b":["L20I"],"nsp3":["I310F","T1465I"]},"labels":{"aa":"ORF7b: L20I; nsp3: I310F, T1465I"}}},{"name":"KU.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KU.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"S":["G213E"],"nsp3":["P1921L"]},"labels":{"aa":"S: G213E; nsp3: P1921L","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9566845893859863}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.104548931121826}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.48.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"nsp2":["A247V"]},"labels":{"aa":"nsp2: A247V"}}},{"name":"NODE_0000865","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF3a":["S60F"],"nsp3":["T943I"]},"labels":{"aa":"ORF3a: S60F; nsp3: T943I"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"LD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"S":["T572I"],"nsp2":["T497I"]},"labels":{"aa":"S: T572I; nsp2: T497I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000867","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.500879764556885}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.500879764556885}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.8.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000868","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.438821315765381}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.6234030723571777}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000869","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.61719274520874}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.61719274520874}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"nsp6":["N205D"]},"labels":{"aa":"nsp6: N205D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77033805847168}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77033805847168}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.424421787261963}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.424421787261963}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.75288200378418}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.045562267303467}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":136,"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":141,"Nextclade_pango":{"value":"LU.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF7b":["F13L"],"S":["Q677P"],"nsp13":["P47T"],"nsp3":["T182I"]},"labels":{"aa":"ORF7b: F13L; S: Q677P; nsp13: P47T; nsp3: T182I","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":137,"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.396651744842529}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":143,"Nextclade_pango":{"value":"LU.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF9b":["L64P"],"S":["S60P","K182N"],"nsp2":["L24F"],"nsp3":["T1036I"]},"labels":{"aa":"ORF9b: L64P; S: S60P, K182N; nsp2: L24F; nsp3: T1036I","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.772427558898926}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.772427558898926}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.49.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.49.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.320776462554932}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_d6241d6f","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.515070915222168}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.49.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"nsp2":["D391A"]},"labels":{"aa":"nsp2: D391A"}}},{"name":"internal_0257fb60","node_attrs":{"div":134,"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"ORF10":["I27K"],"S":["S31F","F456V"]},"labels":{"aa":"ORF10: I27K; S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"nsp2":["E490K"]},"labels":{"aa":"nsp2: E490K"}}},{"name":"NODE_0000878","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000879","node_attrs":{"div":138,"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"nsp2":["T44I"]},"labels":{"aa":"nsp2: T44I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MB.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.30217999999999995"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000880","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.30778169631958}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.30778169631958}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.58.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.408945560455322}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.224411964416504}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.872320652008057}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.872320652008057}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.468550205230713}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"S":["F456L"],"nsp6":["T96K"]},"labels":{"aa":"S: F456L; nsp6: T96K","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"S":["V62F","F456V"],"nsp13":["T216S"],"nsp3":["A1711V"]},"labels":{"aa":"S: V62F, F456V; nsp13: T216S; nsp3: A1711V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.532392978668213}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"nsp3":["N1329S"]},"labels":{"aa":"nsp3: N1329S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.532392978668213}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.342892169952393}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.64.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.342892169952393}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"MD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"S":["F456V"],"nsp4":["T37I"]},"labels":{"aa":"S: F456V; nsp4: T37I","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":131,"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.914387226104736}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"MD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.914387226104736}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"MD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":134,"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3","node_attrs":{"div":134,"Nextclade_pango":{"value":"MD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"MD.3.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MD.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.229282379150391}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005563735961914}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9326608180999756}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.02389"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.131450176239014}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":134,"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KS.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"S":["T22N"],"nsp3":["L1328F"]},"labels":{"aa":"S: T22N; nsp3: L1328F","spike_mutations":"T22N"}}},{"name":"KS.1.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KS.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.097977638244629}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"nsp13":["A296S"]},"labels":{"aa":"nsp13: A296S"}},"children":[{"name":"JN.1.57.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.57.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"S":["S60P"],"nsp6":["I124V"]},"labels":{"aa":"S: S60P; nsp6: I124V","spike_mutations":"S60P"}}},{"name":"JN.1.57","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_dd754174","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"nsp14":["C39F"]},"labels":{"aa":"nsp14: C39F"}}},{"name":"JN.1.7.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08313"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.566636085510254}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6906843185424805}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.1756510734558105}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}}},{"name":"JN.1.7.6","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.7.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"S":["S60P"],"nsp3":["P791S"]},"labels":{"aa":"S: S60P; nsp3: P791S","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"S":["F456L"],"nsp1":["V28I"]},"labels":{"aa":"S: F456L; nsp1: V28I","spike_mutations":"F456L"}}},{"name":"NODE_0000894","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.7.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000895","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":140,"Nextclade_pango":{"value":"MQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF9b":["V96A"],"S":["T678I"],"nsp3":["P74S"]},"labels":{"aa":"ORF9b: V96A; S: T678I; nsp3: P74S","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"nsp5":["H132Y"]},"labels":{"aa":"nsp5: H132Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04395"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"S":["H445P"],"nsp3":["R352C"],"nsp6":["L37F"]},"labels":{"aa":"S: H445P; nsp3: R352C; nsp6: L37F","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":133,"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"LK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{}}},{"name":"LK.2.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95433"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7119815349578857}},"branch_attrs":{"mutations":{"nuc":["C774T"],"nsp1":["T170I"]},"labels":{"aa":"nsp1: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7119815349578857}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.776749610900879}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.743699073791504}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"KQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_3e1a35d0","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.8164443969726562}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.036890983581543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{}}},{"name":"KV.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"KV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"S":["T572I"],"nsp3":["P153L"]},"labels":{"aa":"S: T572I; nsp3: P153L","spike_mutations":"T572I"}}},{"name":"KV.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.782619953155518}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.782619953155518}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.02389"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000904","node_attrs":{"div":131,"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.769268035888672}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.769268035888672}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.145790100097656}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"LE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"S":["K304N"],"nsp12":["T739I"]},"labels":{"aa":"S: K304N; nsp12: T739I","spike_mutations":"K304N"}}},{"name":"NODE_0000905","node_attrs":{"div":137,"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3.1","node_attrs":{"div":143,"Nextclade_pango":{"value":"LE.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}},{"name":"LE.1.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.5280258655548096}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"nsp2":["F319L"]},"labels":{"aa":"nsp2: F319L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.5280258655548096}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.900146961212158}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"S":["H445P","F456L"],"nsp3":["S1265I"]},"labels":{"aa":"S: H445P, F456L; nsp3: S1265I","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000907","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.64257287979126}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.64257287979126}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972496032714844}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972496032714844}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":132,"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.621585369110107}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"nsp13":["V169F"]},"labels":{"aa":"nsp13: V169F"}},"children":[{"name":"KZ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"KZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.621585369110107}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":133,"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KZ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"S":["T572I"],"nsp3":["L728I"]},"labels":{"aa":"S: T572I; nsp3: L728I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000912","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.3227221965789795}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.10","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.885519981384277}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.391621112823486}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.850338935852051}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000913","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"KR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":137,"Nextclade_pango":{"value":"KR.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"nsp2":["L462F"],"nsp3":["T1269I"]},"labels":{"aa":"nsp2: L462F; nsp3: T1269I"}}},{"name":"NODE_0000914","node_attrs":{"div":136,"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"S":["Q218E"],"nsp14":["I15T"]},"labels":{"aa":"S: Q218E; nsp14: I15T","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KR.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"KR.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2408299999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":11.111},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000915","node_attrs":{"div":134,"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.3","node_attrs":{"div":143,"Nextclade_pango":{"value":"KR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"S":["S60P","K304Q"],"nsp2":["L24F","Q275K"],"nsp3":["I1528V"]},"labels":{"aa":"S: S60P, K304Q; nsp2: L24F, Q275K; nsp3: I1528V","spike_mutations":"S60P, K304Q"}}},{"name":"KR.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}}]}]}]}]},{"name":"NODE_0000916","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.056101322174072}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.056101322174072}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6075029373168945}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"S":["T572I"],"nsp4":["A380V"]},"labels":{"aa":"S: T572I; nsp4: A380V","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.143343448638916}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.143343448638916}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":131,"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9964091777801514}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"S":["V1104L"],"nsp3":["A1690D"]},"labels":{"aa":"S: V1104L; nsp3: A1690D","spike_mutations":"V1104L"}}},{"name":"LB.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9964091777801514}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.6","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695721626281738}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"S":["I670M"],"nsp3":["S1699P"]},"labels":{"aa":"S: I670M; nsp3: S1699P","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"S":["L1143F"],"nsp14":["T97I"]},"labels":{"aa":"S: L1143F; nsp14: T97I","spike_mutations":"L1143F"}}},{"name":"LB.1.8","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.729191780090332}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"S":["-31S"],"nsp2":["I605V"]},"labels":{"aa":"S: -31S; nsp2: I605V","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2408299999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000919","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.558164596557617}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"nsp3":["A655V"]},"labels":{"aa":"nsp3: A655V"}},"children":[{"name":"LB.1.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.558164596557617}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LB.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000920","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"nsp15":["G17R"]},"labels":{"aa":"nsp15: G17R"}},"children":[{"name":"LB.1.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.662420749664307}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"S":["F175L"],"nsp3":["I750F"]},"labels":{"aa":"S: F175L; nsp3: I750F","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"nsp3":["L689F"]},"labels":{"aa":"nsp3: L689F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LB.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000922","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"nsp14":["T31I"]},"labels":{"aa":"nsp14: T31I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF7a":["T28I"],"S":["H445P"],"nsp1":["V84-","M85-"]},"labels":{"aa":"N: T379I; ORF7a: T28I; S: H445P; nsp1: V84-, M85-","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.472050666809082}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.925825357437134}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.925825357437134}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.347440719604492}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000925","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.68872594833374}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.16.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.004867076873779}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF7a":["F59K"],"nsp2":["G220S"]},"labels":{"aa":"ORF7a: F59K; nsp2: G220S"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.16.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_dc847259","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.413978576660156}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.413978576660156}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LA.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"]}}},{"name":"LA.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"LA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.04741999999999978"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"S":["T346I"]},"labels":{"aa":"S: T346I","spike_mutations":"T346I"}}}]}]},{"name":"internal_acb00454","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.084030628204346}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.084030628204346}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.0966057777404785}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF3a":["Y184H"],"S":["S31-"],"nsp2":["K67R"]},"labels":{"aa":"ORF3a: Y184H; S: S31-; nsp2: K67R","spike_mutations":"S31-"}}},{"name":"LF.5","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","A22115G","C28660T"],"S":["T33A","N185D"]},"labels":{"aa":"S: T33A, N185D","spike_mutations":"T33A, N185D"}}},{"name":"LF.6","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":143,"Nextclade_pango":{"value":"LF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21767999999999987"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":50.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.817229820305529"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"],"nsp3":["S1717L"]},"labels":{"aa":"ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R; nsp3: S1717L","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"nsp10":["T115I"]},"labels":{"aa":"N: R385K; nsp10: T115I"}},"children":[{"name":"LF.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LF.4.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF8":["Q29*"],"S":["S31-"],"nsp2":["G339S"]},"labels":{"aa":"ORF8: Q29*; S: S31-; nsp2: G339S","spike_mutations":"S31-"}}}]},{"name":"NODE_0000931","node_attrs":{"div":131,"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6508469581604}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":131,"Nextclade_pango":{"value":"LF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6508469581604}},"branch_attrs":{"mutations":{}}},{"name":"LF.9.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.385717391967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"nsp3":["A450T","S1285F"]},"labels":{"aa":"nsp3: A450T, S1285F"}},"children":[{"name":"LF.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF8":["I121-"],"nsp10":["A32V"]},"labels":{"aa":"ORF8: I121-; nsp10: A32V"}},"children":[{"name":"LF.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LF.3.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LF.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}}]}]},{"name":"NODE_0000936","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000937","node_attrs":{"div":136,"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LF.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"nsp14":["Y64H"]},"labels":{"aa":"nsp14: Y64H"}}},{"name":"LF.8.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LF.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"S":["T22N"],"nsp10":["L138F"]},"labels":{"aa":"S: T22N; nsp10: L138F","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.106708526611328}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.106708526611328}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.18.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp15":["S288F"],"nsp2":["A510V"]},"labels":{"aa":"S: S31-; nsp15: S288F; nsp2: A510V","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.95346736907959}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.95346736907959}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"],"nsp3":["E122D","A1766T"]},"labels":{"aa":"S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A; nsp3: E122D, A1766T","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.18.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{}}},{"name":"LH.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"LH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"S":["I197V","P251H"],"nsp3":["E948A"]},"labels":{"aa":"S: I197V, P251H; nsp3: E948A","spike_mutations":"I197V, P251H"}}},{"name":"LH.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.221216201782227}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"S":["K182I"],"nsp2":["G424S"]},"labels":{"aa":"S: K182I; nsp2: G424S","spike_mutations":"K182I"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.8283514976501465}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.8283514976501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":133,"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.243719577789307}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"ORF10":["N36S"],"S":["S31-","R190S"]},"labels":{"aa":"ORF10: N36S; S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"MA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.795657634735107}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":136,"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"MA.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MA.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3926199999999998"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":11.111},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.4456329345703125}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.4456329345703125}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":131,"Nextclade_pango":{"value":"LQ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"nsp3":["T943I"]},"labels":{"aa":"nsp3: T943I"}}},{"name":"internal_7901df09","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.520936012268066}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"S":["N556K"],"nsp2":["T3A"]},"labels":{"aa":"S: N556K; nsp2: T3A","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":132,"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"LQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.721512794494629}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"internal_01daa250","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.106212139129639}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"S":["D80Y","P174S","S689N"],"nsp13":["L428F"]},"labels":{"aa":"S: D80Y, P174S, S689N; nsp13: L428F","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"NODE_0000949","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.172158718109131}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.172158718109131}},"branch_attrs":{"mutations":{}}},{"name":"LY.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"S":["Q183H"],"nsp3":["T1184M"],"nsp4":["A472T"]},"labels":{"aa":"S: Q183H; nsp3: T1184M; nsp4: A472T","spike_mutations":"Q183H"}}},{"name":"LY.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.744548320770264}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"NODE_0000950","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"NODE_0000951","node_attrs":{"div":134,"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G"],"nsp3":["K408E"]},"labels":{"aa":"nsp3: K408E"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LZ.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"2-3 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C29642T"],"ORF10":["Q29*"]},"labels":{"aa":"ORF10: Q29*"}}},{"name":"LZ.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]},{"name":"internal_24bd909c","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C22928T"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.18.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"internal_41eb7227","node_attrs":{"div":138,"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"nsp2":["I560V"]},"labels":{"aa":"N: A152T; nsp2: I560V"}},"children":[{"name":"LZ.1.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"LZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}},{"name":"LZ.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.858034133911133}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.858034133911133}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"S":["F456L"],"nsp3":["T1465I"]},"labels":{"aa":"S: F456L; nsp3: T1465I","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.6","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.04741999999999978"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-6.00890588760376}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"KP.5","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000956","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"internal_181bd2e5","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.27333999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7741516492587035"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"S":["S31-"],"nsp2":["M418V"]},"labels":{"aa":"S: S31-; nsp2: M418V","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.4.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"nsp12":["T141I"]},"labels":{"aa":"nsp12: T141I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.4.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.4.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"S":["G35R"],"nsp2":["G339S"],"nsp3":["I1409V"]},"labels":{"aa":"S: G35R; nsp2: G339S; nsp3: I1409V","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000961","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"S":["K182N"],"nsp15":["L162F"]},"labels":{"aa":"S: K182N; nsp15: L162F","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"S":["T572I","K679N"],"nsp4":["V328I"]},"labels":{"aa":"S: T572I, K679N; nsp4: V328I","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"S":["T572I"],"nsp10":["P86T"],"nsp14":["T378I"]},"labels":{"aa":"S: T572I; nsp10: P86T; nsp14: T378I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"S":["S71Y"],"nsp15":["T325I"]},"labels":{"aa":"S: S71Y; nsp15: T325I","spike_mutations":"S71Y"}}},{"name":"LP.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"S":["K182E"],"nsp12":["R285S"]},"labels":{"aa":"S: K182E; nsp12: R285S","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":139,"Nextclade_pango":{"value":"LP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_bfd296bd","node_attrs":{"div":136,"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000967","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"LP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"internal_55cfa969","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.616637706756592}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"S":["L56V"],"nsp3":["T1275I"]},"labels":{"aa":"S: L56V; nsp3: T1275I","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.14","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.12","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"S":["V1176F"],"nsp2":["E19K"]},"labels":{"aa":"S: V1176F; nsp2: E19K","spike_mutations":"V1176F"}}},{"name":"KP.2.19","node_attrs":{"div":140,"Nextclade_pango":{"value":"KP.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"S":["S31-"],"nsp1":["V28I"]},"labels":{"aa":"S: S31-; nsp1: V28I","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"S":["S60P"],"nsp14":["K147I"]},"labels":{"aa":"S: S60P; nsp14: K147I","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"nsp12":["D445N"]},"labels":{"aa":"nsp12: D445N"}},"children":[{"name":"KP.2.20","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.20.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.096656799316406}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}}]},{"name":"internal_53692388","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000972","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.40119000000000016"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7908990401504723"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.2.3.4","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"NODE_0000973","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"nsp3":["T1303A"]},"labels":{"aa":"nsp3: T1303A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF6":["L16I"],"S":["Q239R"],"nsp2":["I605V"]},"labels":{"aa":"ORF6: L16I; S: Q239R; nsp2: I605V","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000974","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.916172504425049}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21942999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.17","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.16","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.532754898071289}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp6":["V149F"]},"labels":{"aa":"S: S31-; nsp6: V149F","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.321987628936768}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000975","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"KP.3.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"S":["S31F"],"nsp3":["E374K"]},"labels":{"aa":"N: A134V; S: S31F; nsp3: E374K","spike_mutations":"S31F"}}},{"name":"KP.3.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"KP.3.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5554650921238282"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"S":["A435S"],"nsp8":["N192T"]},"labels":{"aa":"S: A435S; nsp8: N192T","spike_mutations":"A435S"}}},{"name":"NODE_0000978","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"nsp3":["I549L"]},"labels":{"aa":"nsp3: I549L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"S":["S31-"],"nsp3":["V418I"]},"labels":{"aa":"S: S31-; nsp3: V418I","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"ML.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"ML.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.4867472648620605}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.350050449371338}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000982","node_attrs":{"div":140,"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"LW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"LW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"S":["T33I"],"nsp4":["P29S"]},"labels":{"aa":"S: T33I; nsp4: P29S","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":142,"Nextclade_pango":{"value":"LW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000983","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.7","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"KP.3.1.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF3a":["I186V"],"S":["N556K"],"nsp3":["Q180H"]},"labels":{"aa":"ORF3a: I186V; S: N556K; nsp3: Q180H","spike_mutations":"N556K"}}},{"name":"NODE_0000984","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"MY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"nsp14":["P151S"]},"labels":{"aa":"nsp14: P151S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"MM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000986","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}},{"name":"MK.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"MK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.3","node_attrs":{"div":143,"Nextclade_pango":{"value":"MK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.11924"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7206397516519647"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"S":["R346T","H445R"],"nsp2":["L113F"],"nsp3":["S454G","T1251N","D1774Y"]},"labels":{"aa":"S: R346T, H445R; nsp2: L113F; nsp3: S454G, T1251N, D1774Y","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"S":["S151I"],"nsp3":["A1311V"]},"labels":{"aa":"S: S151I; nsp3: A1311V","spike_mutations":"S151I"}}},{"name":"NODE_0000988","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp10":["S33C"]},"labels":{"aa":"S: S31-; nsp10: S33C","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.15","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.910944700241089}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.14","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.02898645401001}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.3","node_attrs":{"div":142,"Nextclade_pango":{"value":"MC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.6","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.3801984786987305}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"nsp2":["P589S"],"nsp3":["G1273S"]},"labels":{"aa":"nsp2: P589S; nsp3: G1273S"}}},{"name":"MC.7","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.3172000000000001"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5369762101413171"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-6.544749736785889}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.4","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.9","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.347929000854492}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF3a":["K75N"],"nsp13":["A296S"]},"labels":{"aa":"ORF3a: K75N; nsp13: A296S"}}},{"name":"NODE_0000989","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MC.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000990","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MC.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.050478935241699}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"MC.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":74,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7695722579956055}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000994","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.526405334472656}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.8"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.526405334472656}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000995","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF7b":["L11F"],"nsp1":["K141-","S142-","F143-"]},"labels":{"aa":"ORF7b: L11F; nsp1: K141-, S142-, F143-"}},"children":[{"name":"BA.4","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"nsp3":["H818Q"]},"labels":{"aa":"nsp3: H818Q"}}},{"name":"NODE_0000996","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.9144246578216553}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.222130537033081}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"nsp16":["P236L"]},"labels":{"aa":"nsp16: P236L"}}},{"name":"BA.4.5","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.7"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.027554035186768}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000997","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.7857275009155273}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.7857275009155273}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.9799063205718994}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.2","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"S":["V445A"],"nsp3":["D505G","M1441I"]},"labels":{"aa":"S: V445A; nsp3: D505G, M1441I","spike_mutations":"V445A"}}},{"name":"BA.4.6.3","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.71883"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"S":["Y144-","K444N","N460K"],"nsp3":["G145C"]},"labels":{"aa":"S: Y144-, K444N, N460K; nsp3: G145C","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.4","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000998","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":82,"Nextclade_pango":{"value":"DC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66094"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"internal_813c","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.7295260429382324}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF9b":["P51L"],"nsp2":["R544G"]},"labels":{"aa":"ORF9b: P51L; nsp2: R544G"}}},{"name":"BA.4.1.5","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.4.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"BA.4.1.6","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"nsp10":["T102I"]},"labels":{"aa":"nsp10: T102I"}}},{"name":"BA.4.1.9","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.9"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.8"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8587093353271484}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001000","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"nsp12":["L323F"]},"labels":{"aa":"nsp12: L323F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF7a":["P84L"],"nsp3":["P153S"]},"labels":{"aa":"ORF7a: P84L; nsp3: P153S"}}},{"name":"BA.4.1.7","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.7"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"S":["Q52R"],"nsp14":["D301G"],"nsp3":["D1122G"]},"labels":{"aa":"S: Q52R; nsp14: D301G; nsp3: D1122G","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001001","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.4.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.11"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0001002","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.67074"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5308081831240151"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"CS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5702799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7561969850799493"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"S":["K444R"],"nsp13":["E341D"]},"labels":{"aa":"S: K444R; nsp13: E341D","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0001003","node_attrs":{"div":82,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.162142753601074}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":82,"Nextclade_pango":{"value":"BA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.162142753601074}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39901000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2395057678222656}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"S":["R346I"],"nsp6":["T181I"]},"labels":{"aa":"S: R346I; nsp6: T181I","spike_mutations":"R346I"}}},{"name":"NODE_0001004","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9982612133026123}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"nsp3":["M1278L"]},"labels":{"aa":"nsp3: M1278L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF7a":["H47D"],"nsp1":["E91K"],"nsp2":["T170I"]},"labels":{"aa":"ORF7a: H47D; nsp1: E91K; nsp2: T170I"}}},{"name":"BA.5.8","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"S":["P1162L"],"nsp13":["V348L"],"nsp15":["T325I"]},"labels":{"aa":"S: P1162L; nsp13: V348L; nsp15: T325I","spike_mutations":"P1162L"}}}]},{"name":"NODE_0001005","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9458131790161133}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.243049144744873}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"nsp12":["G671V"]},"labels":{"aa":"nsp12: G671V"}}},{"name":"BA.5.5","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9458131790161133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001006","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.89169979095459}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5131309032440186}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"nsp12":["L323R"],"nsp4":["V403F"]},"labels":{"aa":"nsp12: L323R; nsp4: V403F"}}}]}]},{"name":"NODE_0001007","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0763678550720215}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"nsp13":["A389V"],"nsp16":["T140I"]},"labels":{"aa":"nsp13: A389V; nsp16: T140I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0763678550720215}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001008","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1130268573760986}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"nsp14":["M315I"]},"labels":{"aa":"nsp14: M315I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9632551670074463}},"branch_attrs":{"mutations":{"nuc":["T29597C"],"ORF10":["Y14H"]},"labels":{"aa":"ORF10: Y14H"}}},{"name":"BA.5.6.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5883099999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}},{"name":"BA.5.6.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001009","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001010","node_attrs":{"div":91,"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"S":["N460K"],"nsp2":["V447I"]},"labels":{"aa":"S: N460K; nsp2: V447I","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6570799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"S":["Y144-","R346S"],"nsp3":["I733V"]},"labels":{"aa":"S: Y144-, R346S; nsp3: I733V","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0001011","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BW.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"nsp13":["P78S"]},"labels":{"aa":"nsp13: P78S"}}},{"name":"BW.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"nsp3":["L46F"]},"labels":{"aa":"nsp3: L46F"}}}]}]}]}]},{"name":"NODE_0001012","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.2667036056518555}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"],"ORF10":["L37F"]},"labels":{"aa":"ORF10: L37F"}},"children":[{"name":"BA.5.1","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.2667036056518555}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4272186756134033}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.96599817276001}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"nsp3":["S1578I"]},"labels":{"aa":"nsp3: S1578I"}}},{"name":"BA.5.1.16","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.954094409942627}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF7a":["G26D"],"nsp3":["M84V"]},"labels":{"aa":"ORF7a: G26D; nsp3: M84V"}}},{"name":"BA.5.1.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"nsp3":["I1550T"],"nsp7":["Q63R"]},"labels":{"aa":"N: A211S; nsp3: I1550T; nsp7: Q63R"}}},{"name":"BA.5.1.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2638373374938965}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.17","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7746376991271973}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.24","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3640358448028564}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"nsp13":["V348L"]},"labels":{"aa":"nsp13: V348L"}}},{"name":"BA.5.1.28","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257040023803711}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1503190994262695}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9021759033203125}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"S":["K147-","N148-","P1162S"],"nsp1":["G82-","H83-","V84-","M85-"],"nsp2":["P446L"]},"labels":{"aa":"S: K147-, N148-, P1162S; nsp1: G82-, H83-, V84-, M85-; nsp2: P446L","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"nsp13":["R155L"],"nsp3":["V299I","S692C"]},"labels":{"aa":"nsp13: R155L; nsp3: V299I, S692C"}}},{"name":"BA.5.1.7","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.88628888130188}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"nsp12":["A529V"],"nsp15":["T281I"]},"labels":{"aa":"nsp12: A529V; nsp15: T281I"}}},{"name":"BA.5.1.8","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6331071853637695}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"nsp16":["T151I"],"nsp9":["T21I"]},"labels":{"aa":"nsp16: T151I; nsp9: T21I"}}},{"name":"BA.5.1.5","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1470396518707275}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.6","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.541717767715454}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"nsp3":["V635I"]},"labels":{"aa":"nsp3: V635I"}}},{"name":"NODE_0001013","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF9b":["T60I"],"nsp6":["K270R"]},"labels":{"aa":"ORF9b: T60I; nsp6: K270R"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"BK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"nsp2":["G339S"]},"labels":{"aa":"nsp2: G339S"}}}]},{"name":"internal_6f22","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"nsp5":["H246Y"]},"labels":{"aa":"nsp5: H246Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"DL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0001015","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"nsp13":["S350L"]},"labels":{"aa":"nsp13: S350L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"DH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"S":["Y145-","H146-"],"nsp3":["T1275I","A1381T","S1913G"]},"labels":{"aa":"S: Y145-, H146-; nsp3: T1275I, A1381T, S1913G","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0001016","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"CU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3032753467559814}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF9b":["P51L"],"nsp13":["V247I"],"nsp3":["P874S"]},"labels":{"aa":"ORF9b: P51L; nsp13: V247I; nsp3: P874S"}}},{"name":"BA.5.1.38","node_attrs":{"div":95,"Nextclade_pango":{"value":"BA.5.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"],"nsp16":["A192T"]},"labels":{"aa":"ORF8: S103L; ORF9b: T83I; S: R346T; nsp16: A192T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"nsp3":["I707M"]},"labels":{"aa":"nsp3: I707M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"EB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001019","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF9b":["T95M"],"S":["V1264L"],"nsp12":["G671S"],"nsp3":["T626A"]},"labels":{"aa":"ORF9b: T95M; S: V1264L; nsp12: G671S; nsp3: T626A","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"EQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8467981815338135}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"nsp2":["S122F"]},"labels":{"aa":"nsp2: S122F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8467981815338135}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.115823268890381}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF3a":["R134C"],"S":["G181V","R346T"],"nsp12":["M629T"],"nsp2":["A488T"]},"labels":{"aa":"ORF3a: R134C; S: G181V, R346T; nsp12: M629T; nsp2: A488T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"DE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0001022","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4300601482391357}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"nsp14":["D379N"]},"labels":{"aa":"nsp14: D379N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF7a":["L30H"],"S":["R346T"],"nsp12":["T319I"],"nsp13":["A553S"],"nsp2":["H237Y"]},"labels":{"aa":"ORF7a: L30H; S: R346T; nsp12: T319I; nsp13: A553S; nsp2: H237Y","spike_mutations":"R346T"}}},{"name":"NODE_0001023","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.069719314575195}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"nsp12":["G671S"]},"labels":{"aa":"nsp12: G671S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.069719314575195}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"BT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_b005","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5216658115386963}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"nsp13":["N102S"]},"labels":{"aa":"nsp13: N102S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7831978797912598}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":92,"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"CL.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001027","node_attrs":{"div":94,"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.229829788208008}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"internal_2d50","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8071255683898926}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8071255683898926}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":89,"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.107795715332031}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"DJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.107795715332031}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001030","node_attrs":{"div":90,"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.246993541717529}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"DJ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"nsp14":["T173A"],"nsp5":["T24I"]},"labels":{"aa":"nsp14: T173A; nsp5: T24I"}}},{"name":"DJ.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF9b":["D2N"],"S":["L176F"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp4":["L106F"],"nsp8":["I185V"]},"labels":{"aa":"N: G5E; ORF9b: D2N; S: L176F; nsp1: G82-, H83-, V84-, M85-, V86-; nsp4: L106F; nsp8: I185V","spike_mutations":"L176F"}}},{"name":"NODE_0001031","node_attrs":{"div":92,"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"DJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"DJ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"NODE_0001032","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7332913875579834}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0832855701446533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0474534034729}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"nsp12":["G671C"]},"labels":{"aa":"nsp12: G671C"}}},{"name":"BA.5.1.32","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF9b":["V76F"],"nsp13":["P504S"],"nsp14":["D41N"]},"labels":{"aa":"N: S79I, A273S; ORF9b: V76F; nsp13: P504S; nsp14: D41N"}}},{"name":"BA.5.1.9","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.180713653564453}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF6":["D6G"],"nsp12":["M463V"]},"labels":{"aa":"ORF6: D6G; nsp12: M463V"}}},{"name":"NODE_0001033","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.130020618438721}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.533609390258789}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"nsp3":["K589M"]},"labels":{"aa":"nsp3: K589M"}}},{"name":"BA.5.1.36","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF9b":["L14F"],"S":["G261V"],"nsp7":["V33A"]},"labels":{"aa":"N: G18C; ORF9b: L14F; S: G261V; nsp7: V33A","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"NODE_0001034","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.150343418121338}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7931668758392334}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"S":["A262S"],"nsp2":["R27C"],"nsp7":["Q63R"]},"labels":{"aa":"E: S50G; S: A262S; nsp2: R27C; nsp7: Q63R","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001036","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"S":["R346T"],"nsp16":["T35I"]},"labels":{"aa":"S: R346T; nsp16: T35I","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001037","node_attrs":{"div":94,"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp3":["Q380R"]},"labels":{"aa":"S: Y144-; nsp3: Q380R","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"DF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7062840461730957}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7062840461730957}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001039","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6787030696868896}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6787030696868896}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5279"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.953214645385742}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.078192710876465}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"S":["N450D"],"nsp13":["H164Y"]},"labels":{"aa":"S: N450D; nsp13: H164Y","spike_mutations":"N450D"}}},{"name":"BF.19","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.091021537780762}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.17","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.485513687133789}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"nsp4":["D117N"]},"labels":{"aa":"nsp4: D117N"}}},{"name":"BF.33","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6034899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"S":["R346I","N460K"],"nsp12":["N791S"],"nsp16":["T35I"]},"labels":{"aa":"S: R346I, N460K; nsp12: N791S; nsp16: T35I","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.552757501602173}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.914626359939575}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4885289669036865}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0001040","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.624391078948975}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}},"children":[{"name":"BF.30","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C14599T","G22599C","C25916T"],"ORF3a":["T175I"],"S":["R346T"],"nsp3":["T204I"]},"labels":{"aa":"ORF3a: T175I; S: R346T; nsp3: T204I","spike_mutations":"R346T"}}},{"name":"BF.35","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF7a":["T14I"],"S":["N450D"],"nsp12":["M566I"],"nsp2":["L550R"]},"labels":{"aa":"ORF7a: T14I; S: N450D; nsp12: M566I; nsp2: L550R","spike_mutations":"N450D"}}}]},{"name":"NODE_0001041","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.26798677444458}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.26798677444458}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.001974582672119}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.001974582672119}},"branch_attrs":{"mutations":{}}},{"name":"BF.39.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.33263"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5959379308450252"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.379688739776611}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"S":["V445A","N450D"],"nsp13":["R155L"]},"labels":{"aa":"S: V445A, N450D; nsp13: R155L","spike_mutations":"V445A, N450D"}}}]},{"name":"internal_a7a7","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.132727146148682}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.132727146148682}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.41.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"S":["R346T"],"nsp1":["A138V"],"nsp5":["V297I"]},"labels":{"aa":"S: R346T; nsp1: A138V; nsp5: V297I","spike_mutations":"R346T"}}}]},{"name":"NODE_0001044","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.576507329940796}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.576507329940796}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.11.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF8":["I121N"],"nsp2":["S351G"]},"labels":{"aa":"ORF8: I121N; nsp2: S351G"}}},{"name":"BF.11.4","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.462855339050293}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"NODE_0001045","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.166012287139893}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.11.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"S":["K147N"],"nsp3":["T1250P"]},"labels":{"aa":"S: K147N; nsp3: T1250P","spike_mutations":"K147N"}}},{"name":"BF.11.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.11.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.292903900146484}},"branch_attrs":{"mutations":{"nuc":["C629T"],"nsp1":["L122F"]},"labels":{"aa":"nsp1: L122F"}}}]}]},{"name":"NODE_0001046","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7686774730682373}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7894070148468018}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"nsp12":["V320L"]},"labels":{"aa":"nsp12: V320L"}}},{"name":"BF.28","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2664027214050293}},"branch_attrs":{"mutations":{"nuc":["A396T"],"nsp1":["Q44L"]},"labels":{"aa":"nsp1: Q44L"}}},{"name":"BF.36","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"nsp1":["S166G"],"nsp13":["S350L","A505V"]},"labels":{"aa":"nsp1: S166G; nsp13: S350L, A505V"}}},{"name":"BF.9","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.462024211883545}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"nsp13":["A208V"],"nsp3":["G946S"],"nsp6":["Q27H"]},"labels":{"aa":"nsp13: A208V; nsp3: G946S; nsp6: Q27H"}}},{"name":"NODE_0001047","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1384172439575195}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"nsp13":["A368V"]},"labels":{"aa":"N: L13F; nsp13: A368V"}},"children":[{"name":"BF.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1384172439575195}},"branch_attrs":{"mutations":{}}},{"name":"BF.10.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3218"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.563032084337257"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}}]},{"name":"NODE_0001048","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.431779384613037}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"nsp16":["V288F"]},"labels":{"aa":"nsp16: V288F"}},"children":[{"name":"BF.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.431779384613037}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"nsp1":["E87D"],"nsp3":["Y107H","D165G"],"nsp5":["V261I"],"nsp6":["V289L"]},"labels":{"aa":"nsp1: E87D; nsp3: Y107H, D165G; nsp5: V261I; nsp6: V289L"}}}]},{"name":"NODE_0001049","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1216320991516113}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.382207870483398}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.540201187133789}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"nsp3":["T1456N"]},"labels":{"aa":"nsp3: T1456N"}}}]},{"name":"NODE_0001050","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.864048957824707}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF3a":["T175I"],"nsp2":["T44I","L462F"],"nsp3":["D117G"]},"labels":{"aa":"ORF3a: T175I; nsp2: T44I, L462F; nsp3: D117G"}}},{"name":"BF.27","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3812055587768555}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"nsp4":["A21V"]},"labels":{"aa":"nsp4: A21V"}}}]},{"name":"NODE_0001051","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.45866060256958}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.780573606491089}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"S":["R346S"],"nsp14":["K433R"],"nsp3":["K1771R"]},"labels":{"aa":"S: R346S; nsp14: K433R; nsp3: K1771R","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.740543842315674}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"NODE_0001052","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.68562650680542}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.741713047027588}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"nsp3":["L689F"]},"labels":{"aa":"nsp3: L689F"}}},{"name":"internal_faef","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48889999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2785964012146}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"internal_3b8c","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.661747455596924}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"nsp2":["G458C"]},"labels":{"aa":"nsp2: G458C"}}},{"name":"NODE_0001055","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160424709320068}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160424709320068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001056","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.755507469177246}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0001057","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"nsp4":["I110V"]},"labels":{"aa":"nsp4: I110V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.266281604766846}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001058","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.605588436126709}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"nsp6":["K270R"]},"labels":{"aa":"nsp6: K270R"}}},{"name":"NODE_0001059","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BF.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":114,"Nextclade_pango":{"value":"BF.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF3a":["P104S"],"nsp13":["V42I"],"nsp16":["H174Y"],"nsp2":["I387T"],"nsp3":["G334S","K1715R"],"nsp9":["T77I"]},"labels":{"aa":"ORF3a: P104S; nsp13: V42I; nsp16: H174Y; nsp2: I387T; nsp3: G334S, K1715R; nsp9: T77I"}}}]}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.604036331176758}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.42"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF7b":["F13-"],"ORF8":["I39V"],"nsp13":["P504L"],"nsp16":["K160R"],"nsp2":["T85I","T388I"],"nsp3":["A1769V"]},"labels":{"aa":"ORF7b: F13-; ORF8: I39V; nsp13: P504L; nsp16: K160R; nsp2: T85I, T388I; nsp3: A1769V"}}},{"name":"internal_928a","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.397202253341675}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"nsp12":["G385S"]},"labels":{"aa":"nsp12: G385S"}}},{"name":"BF.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257172107696533}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"S":["N450D"],"nsp12":["G671S"],"nsp3":["T734N"]},"labels":{"aa":"S: N450D; nsp12: G671S; nsp3: T734N","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416947364807129}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"S":["G446D"],"nsp3":["S126L"]},"labels":{"aa":"S: G446D; nsp3: S126L","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.40"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.287536382675171}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.238622665405273}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.238622665405273}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.38.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"S":["V445A"],"nsp12":["H613Y"]},"labels":{"aa":"S: V445A; nsp12: H613Y","spike_mutations":"V445A"}}},{"name":"BF.38.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.38.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}},{"name":"BF.38.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}}]},{"name":"NODE_0001063","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.12","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.18","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.17","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"S":["A688V","G1167S"],"nsp13":["I151V"],"nsp3":["A667V"]},"labels":{"aa":"S: A688V, G1167S; nsp13: I151V; nsp3: A667V","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.15","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"S":["G257D"],"nsp3":["A994V"]},"labels":{"aa":"S: G257D; nsp3: A994V","spike_mutations":"G257D"}}},{"name":"BF.7.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6393200000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9261090755462646}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.21","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.23","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.092196941375732}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"nsp12":["T248I"]},"labels":{"aa":"nsp12: T248I"}}},{"name":"BF.7.26","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.24","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.8","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0001064","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"nsp2":["A318V"]},"labels":{"aa":"nsp2: A318V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"S":["A688V"],"nsp3":["A1305V"]},"labels":{"aa":"S: A688V; nsp3: A1305V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001065","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0001066","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"nsp13":["P504L"]},"labels":{"aa":"nsp13: P504L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"S":["Y144-","G181V"],"nsp2":["H532N"]},"labels":{"aa":"M: H155Y; S: Y144-, G181V; nsp2: H532N","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001067","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"nsp2":["H208Y"],"nsp3":["H342Y"]},"labels":{"aa":"nsp2: H208Y; nsp3: H342Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6759999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001068","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"],"nsp2":["I293T"]},"labels":{"aa":"N: A90S; ORF7a: H47N; ORF9b: E86D; S: F157L; nsp2: I293T","spike_mutations":"F157L"}}},{"name":"BF.7.4","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001069","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3122618198394775}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"nsp13":["P504S"]},"labels":{"aa":"nsp13: P504S"}}},{"name":"BF.7.4.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"nsp14":["S221T"],"nsp3":["S1206L"]},"labels":{"aa":"nsp14: S221T; nsp3: S1206L"}}}]}]},{"name":"NODE_0001070","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF7a":["H47Y"],"nsp12":["L247F"]},"labels":{"aa":"ORF7a: H47Y; nsp12: L247F"}},"children":[{"name":"BF.7.27","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0001071","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"S":["C1243F"],"nsp2":["V94L"]},"labels":{"aa":"S: C1243F; nsp2: V94L","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"nsp3":["I385V"],"nsp4":["K138T"]},"labels":{"aa":"nsp3: I385V; nsp4: K138T"}}},{"name":"BF.7.14.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"nsp3":["T1026I"]},"labels":{"aa":"nsp3: T1026I"}}},{"name":"BF.7.14.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.325514793395996}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0001072","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0001073","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6321189403533936}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.815160036087036}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.182589054107666}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.40"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"S":["L5F","N450D"],"nsp15":["D16Y"],"nsp2":["G115C"]},"labels":{"aa":"S: L5F, N450D; nsp15: D16Y; nsp2: G115C","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"nsp3":["C296F","P395L"],"nsp6":["A161V"]},"labels":{"aa":"nsp3: C296F, P395L; nsp6: A161V"}}},{"name":"BA.5.2.9","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.992318630218506}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"nsp12":["Y521C"]},"labels":{"aa":"nsp12: Y521C"}}},{"name":"NODE_0001074","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2580161094665527}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"nsp13":["T127N"]},"labels":{"aa":"nsp13: T127N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.743117332458496}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"nsp3":["M265I"]},"labels":{"aa":"N: A125T; nsp3: M265I"}}},{"name":"BA.5.2.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.626256227493286}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"nsp15":["G246S"]},"labels":{"aa":"N: R413S; nsp15: G246S"}}},{"name":"NODE_0001075","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.856178045272827}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.856178045272827}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"S":["K444M"],"nsp3":["S702F"]},"labels":{"aa":"S: K444M; nsp3: S702F","spike_mutations":"K444M"}}}]},{"name":"NODE_0001076","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.190217971801758}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.498509168624878}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"nsp3":["T204I"]},"labels":{"aa":"nsp3: T204I"}}},{"name":"BA.5.2.28","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2399187088012695}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"nsp3":["T619I"]},"labels":{"aa":"nsp3: T619I"}}},{"name":"BA.5.2.29","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.531074523925781}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"nsp12":["T26I"]},"labels":{"aa":"nsp12: T26I"}}},{"name":"BA.5.2.45","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5131699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.45"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.998836994171143}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.52"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161757469177246}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"S":["N450D"],"nsp3":["D1242N"]},"labels":{"aa":"S: N450D; nsp3: D1242N","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.55"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.999176263809204}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.59"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.273857593536377}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0001077","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9824564456939697}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9824564456939697}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39901000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.402862548828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0001078","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.6803436279296875}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"S":["T883I"],"nsp13":["S74P"]},"labels":{"aa":"S: T883I; nsp13: S74P","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.6803436279296875}},"branch_attrs":{"mutations":{}}},{"name":"DZ.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"DZ.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"S":["D1146Y"],"nsp6":["L98F"]},"labels":{"aa":"S: D1146Y; nsp6: L98F","spike_mutations":"D1146Y"}}}]}]},{"name":"NODE_0001079","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.190217971801758}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"S":["W64L","K444M"],"nsp3":["T1334I"]},"labels":{"aa":"S: W64L, K444M; nsp3: T1334I","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.12","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3988966941833496}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6936419010162354}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"S":["R346T"],"nsp10":["I38V"]},"labels":{"aa":"S: R346T; nsp10: I38V","spike_mutations":"R346T"}}},{"name":"BA.5.2.19","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7941067218780518}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.567555904388428}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.34","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5116841793060303}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"S":["R346T"],"nsp14":["V14L"]},"labels":{"aa":"S: R346T; nsp14: V14L","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6543288230895996}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460197925567627}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.42"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"S":["K444T","L981I"],"nsp13":["S259L"],"nsp3":["A1431V"],"nsp6":["L260F"]},"labels":{"aa":"S: K444T, L981I; nsp13: S259L; nsp3: A1431V; nsp6: L260F","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5642800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5413273873731987"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.43"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"S":["G446D","N460K"],"nsp3":["A861V"]},"labels":{"aa":"S: G446D, N460K; nsp3: A861V","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.44"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.282502174377441}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"nsp3":["L1746F"]},"labels":{"aa":"nsp3: L1746F"}}},{"name":"BA.5.2.46","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.46"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"S":["K444T","N460K"],"nsp2":["K330E"]},"labels":{"aa":"S: K444T, N460K; nsp2: K330E","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.53"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.239440441131592}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.54"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.244083881378174}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.57","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.57"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7188966274261475}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.58","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.58"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.236837387084961}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.62"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.200337886810303}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.63"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"],"nsp2":["A596V"],"nsp3":["T976I"]},"labels":{"aa":"ORF6: Y31C; S: Y144-, K444N, N460K; nsp2: A596V; nsp3: T976I","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.61","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.61"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.71628475189209}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"S":["N450D"],"nsp15":["Q19L"]},"labels":{"aa":"S: N450D; nsp15: Q19L","spike_mutations":"N450D"}}},{"name":"BA.5.2.8","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.947103977203369}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"nsp4":["L106F"]},"labels":{"aa":"nsp4: L106F"}}},{"name":"internal_236a","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3597493171691895}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.216500759124756}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.365072250366211}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.812326431274414}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"nsp3":["I1514V"]},"labels":{"aa":"nsp3: I1514V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.812326431274414}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.800739765167236}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_1651","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.183862686157227}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.183862686157227}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4564899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7208595659836455"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.672360420227051}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.363097667694092}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.56458"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.30660604695253"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.363097667694092}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"DA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6759999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.474554061889648}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001084","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.726138114929199}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"S":["K444R"],"nsp4":["S34F"]},"labels":{"aa":"S: K444R; nsp4: S34F","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.56"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.041224479675293}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.329527378082275}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.329527378082275}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0001086","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.852180480957031}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.280701637268066}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"NODE_0001087","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4698431491851807}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4698431491851807}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"CN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"nsp1":["K120N"]},"labels":{"aa":"nsp1: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{}}},{"name":"BZ.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"S":["Q677H"],"nsp1":["S17N"],"nsp13":["E365D"]},"labels":{"aa":"S: Q677H; nsp1: S17N; nsp13: E365D","spike_mutations":"Q677H"}}},{"name":"BZ.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"S":["N450D"],"nsp4":["H31Y"]},"labels":{"aa":"S: N450D; nsp4: H31Y","spike_mutations":"N450D"}}}]},{"name":"internal_74ef","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.185973167419434}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.185973167419434}},"branch_attrs":{"mutations":{}}},{"name":"CD.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5594199999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3253063676642168"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"S":["A435S"],"nsp3":["A1280V"]},"labels":{"aa":"N: D144N; S: A435S; nsp3: A1280V","spike_mutations":"A435S"}}},{"name":"CD.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"CD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.5595383644104}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}}]},{"name":"NODE_0001090","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.06477689743042}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"nsp14":["P203L"]},"labels":{"aa":"nsp14: P203L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.50"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.740553379058838}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"nsp3":["S1670F"]},"labels":{"aa":"nsp3: S1670F"}}},{"name":"BA.5.2.51","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.51"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.60"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585160732269287}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"S":["N450D"],"nsp6":["K263R"]},"labels":{"aa":"S: N450D; nsp6: K263R","spike_mutations":"N450D"}}}]},{"name":"NODE_0001091","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.064579010009766}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"S":["K444M"],"nsp2":["M418T"]},"labels":{"aa":"S: K444M; nsp2: M418T","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.064579010009766}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"S":["T1066N"],"nsp3":["I1672S"]},"labels":{"aa":"N: P20S; S: T1066N; nsp3: I1672S","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0001092","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"nsp6":["A128V"]},"labels":{"aa":"nsp6: A128V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.205173492431641}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"S":["Y144-","K444M","N460K"],"nsp5":["A94V"]},"labels":{"aa":"S: Y144-, K444M, N460K; nsp5: A94V","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"BU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"S":["K147N","N450D"],"nsp3":["I414T"]},"labels":{"aa":"S: K147N, N450D; nsp3: I414T","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.415645122528076}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.415645122528076}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.35650110244751}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"DB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"S":["Y144-","R346T","N460K"],"nsp14":["M501I"],"nsp2":["A510V"]},"labels":{"aa":"S: Y144-, R346T, N460K; nsp14: M501I; nsp2: A510V","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"DB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.673305034637451}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"internal_93c4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.993546485900879}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0001096","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.665866374969482}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.665866374969482}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001097","node_attrs":{"div":92,"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3630194664001465}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"S":["V62I"],"nsp3":["T183I"]},"labels":{"aa":"S: V62I; nsp3: T183I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40216999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"S":["V445A"],"nsp2":["S263F"]},"labels":{"aa":"N: D377Y; S: V445A; nsp2: S263F","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"S":["H146Q"],"nsp3":["D1774G"]},"labels":{"aa":"S: H146Q; nsp3: D1774G","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0001098","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7056260108947754}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"NODE_0001099","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"S":["K147E"],"nsp14":["T113I"],"nsp2":["M135V"]},"labels":{"aa":"S: K147E; nsp14: T113I; nsp2: M135V","spike_mutations":"K147E"}}}]},{"name":"NODE_0001100","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8918910026550293}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5254948139190674}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"DY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7626357078552246}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"nsp3":["T970M"]},"labels":{"aa":"nsp3: T970M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2117156982421875}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2117156982421875}},"branch_attrs":{"mutations":{}}},{"name":"CP.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6942999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5295255377787571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.206465721130371}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"S":["Y144-","N334K"],"nsp12":["A529T"]},"labels":{"aa":"S: Y144-, N334K; nsp12: A529T","spike_mutations":"Y144-, N334K"}}},{"name":"CP.4","node_attrs":{"div":93,"Nextclade_pango":{"value":"CP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.632293224334717}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.982746124267578}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"CP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.38661"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.8310227394104}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"S":["N460Y"],"nsp5":["K90R"]},"labels":{"aa":"S: N460Y; nsp5: K90R","spike_mutations":"N460Y"}}},{"name":"CP.6","node_attrs":{"div":92,"Nextclade_pango":{"value":"CP.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.885945796966553}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"CP.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"],"nsp2":["Y2H"]},"labels":{"aa":"E: I9T; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y; nsp2: Y2H","spike_mutations":"N703Y"}}},{"name":"internal_7ebe","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"nsp14":["D415G"]},"labels":{"aa":"nsp14: D415G"}},"children":[{"name":"CP.8","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CP.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"S":["P812R"],"nsp14":["L177I"],"nsp3":["P141S","A1179V","V1315I"]},"labels":{"aa":"S: P812R; nsp14: L177I; nsp3: P141S, A1179V, V1315I","spike_mutations":"P812R"}}}]},{"name":"NODE_0001103","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.436225414276123}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.436225414276123}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.319653511047363}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"S":["K150N"],"nsp3":["S1296F"]},"labels":{"aa":"S: K150N; nsp3: S1296F","spike_mutations":"K150N"}}},{"name":"CP.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.3846282958984375}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6003199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"S":["Y144-","G446S"],"nsp6":["A128V"]},"labels":{"aa":"S: Y144-, G446S; nsp6: A128V","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"NODE_0001104","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.071214199066162}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.071214199066162}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.241343975067139}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.667091369628906}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.667091369628906}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.376060962677002}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.376060962677002}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001107","node_attrs":{"div":97,"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"S":["S255F"],"nsp2":["V530I"],"nsp6":["G9D"]},"labels":{"aa":"S: S255F; nsp2: V530I; nsp6: G9D","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CK.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0001108","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.083750247955322}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.083750247955322}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0001109","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.607499599456787}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"CK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"nsp6":["M164V"]},"labels":{"aa":"nsp6: M164V"}}},{"name":"CK.1.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}}]},{"name":"NODE_0001110","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.002077102661133}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"CK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.712399482727051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"CK.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.71883"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"S":["-144Y","R346T"],"nsp4":["S34F"]},"labels":{"aa":"S: -144Y, R346T; nsp4: S34F","spike_mutations":"-144Y, R346T"}}}]},{"name":"NODE_0001111","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.022307395935059}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"S":["E654K"],"nsp3":["T970M"]},"labels":{"aa":"S: E654K; nsp3: T970M","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.657642364501953}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CK.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.022307395935059}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]}]},{"name":"NODE_0001112","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161224365234375}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"nsp2":["Q376K"]},"labels":{"aa":"nsp2: Q376K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161224365234375}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:72-122"},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7826626300811768}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp3":["S1375F"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; nsp1: G82-, H83-, V84-, M85-, V86-; nsp3: S1375F"}}},{"name":"BA.5.3.5","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3075408935546875}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"R346T"}}},{"name":"NODE_0001113","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8096206188201904}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9212589263916016}},"branch_attrs":{"mutations":{"nuc":["G621A"],"nsp1":["R119H"]},"labels":{"aa":"nsp1: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.250945091247559}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"nsp16":["M20I"]},"labels":{"aa":"nsp16: M20I"}}}]},{"name":"NODE_0001114","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{}}},{"name":"BE.3","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2200913429260254}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"nsp13":["Y324C"]},"labels":{"aa":"N: P151S; nsp13: Y324C"}}},{"name":"BE.5","node_attrs":{"div":84,"Nextclade_pango":{"value":"BE.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{}}},{"name":"BE.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"BE.8"},"qc.stopCodons.totalStopCodons":{"value":1},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":94},"qc.overallScore":{"value":56.25},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C1853T","C14178T","C22498T","G22599C","C26110T","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-","A27748-","T28693C"],"ORF3a":["P240S"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-","K119*"],"S":["R346T"],"nsp1":["M85-"]},"labels":{"aa":"ORF3a: P240S; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-, K119*; S: R346T; nsp1: M85-","spike_mutations":"R346T"}}},{"name":"NODE_0001115","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4670610427856445}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BE.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"nsp1":["S74L"],"nsp4":["S59F"],"nsp7":["M52T"]},"labels":{"aa":"nsp1: S74L; nsp4: S59F; nsp7: M52T"}}},{"name":"BE.9","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.663193702697754}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"S":["Y144-"],"nsp1":["V84-","M85-"]},"labels":{"aa":"S: Y144-; nsp1: V84-, M85-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0001116","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6816246509552}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.12","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.008347988128662}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0001117","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.286231994628906}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T"],"nsp1":["M85-"]},"labels":{"aa":"nsp1: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.737891674041748}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0001118","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.440604209899902}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":94,"Nextclade_pango":{"value":"BE.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5231200000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5088823627149919"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","-519T","-520G","T2665C","C3176T","T22624C","A22995G","C23802T","A26170G","C27393T"],"ORF3a":["M260V"],"S":["K478R","T747I"],"nsp3":["P153S"]},"labels":{"aa":"ORF3a: M260V; S: K478R, T747I; nsp3: P153S","spike_mutations":"K478R, T747I"}}},{"name":"BE.7","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.440604209899902}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0001119","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.679184913635254}},"branch_attrs":{"mutations":{"nuc":["C13342T"]}},"children":[{"name":"BE.2","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8559343814849854}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G"],"nsp3":["T64I"]},"labels":{"aa":"nsp3: T64I"}}},{"name":"NODE_0001120","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{"nuc":["C10188A","C27800T"],"nsp5":["T45N"]},"labels":{"aa":"nsp5: T45N"}},"children":[{"name":"BE.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001121","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281903266906738}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.614480018615723}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0001122","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"S":["P209L","R346T"],"nsp3":["T350I"]},"labels":{"aa":"S: P209L, R346T; nsp3: T350I","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001123","node_attrs":{"div":92,"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BE.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"CQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40216999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9200549125671387}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"],"nsp3":["H323Y"]},"labels":{"aa":"S: Y144-, V445A; nsp3: H323Y","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0001124","node_attrs":{"div":93,"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"CQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"CQ.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"CQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]}]}]}]}]}]},{"name":"NODE_0001125","node_attrs":{"div":85,"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.024914026260376}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"nsp13":["M233I"]},"labels":{"aa":"nsp13: M233I"}},"children":[{"name":"BE.1","node_attrs":{"div":85,"Nextclade_pango":{"value":"BE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.024914026260376}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"S":["M153I","E1258Q"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp2":["L274F"]},"labels":{"aa":"N: P151L; S: M153I, E1258Q; nsp1: G82-, H83-, V84-, M85V; nsp2: L274F","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0001126","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.295690059661865}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.295690059661865}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001127","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"S":["V445A"],"nsp2":["F498L"]},"labels":{"aa":"S: V445A; nsp2: F498L","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49383999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8224959014481948"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"S":["N460S"],"nsp4":["T73I"]},"labels":{"aa":"S: N460S; nsp4: T73I","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0001128","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"nsp14":["V263I"]},"labels":{"aa":"nsp14: V263I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BE.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0001129","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.36769437789917}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BE.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BE.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"],"nsp16":["K160R"],"nsp5":["I78T"]},"labels":{"aa":"ORF8: P93T; ORF9b: S10F; S: R346T; nsp16: K160R; nsp5: I78T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0001130","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7709906101226807}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"nsp6":["L260F"]},"labels":{"aa":"nsp6: L260F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7709906101226807}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001131","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"S":["N450D"],"nsp3":["K384N"]},"labels":{"aa":"S: N450D; nsp3: K384N","spike_mutations":"N450D"}}}]},{"name":"BE.1.1_internal","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.037106990814209}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.037106990814209}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45205000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5680790723509552"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.677981853485107}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0001133","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3801355361938477}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"S":["N460K"],"nsp12":["Y273H"]},"labels":{"aa":"S: N460K; nsp12: Y273H","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3801355361938477}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.14","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4368529319763184}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.12","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3855841159820557}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.19","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6127800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7257362514460642"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.9549241065979}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.17","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.20","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5446"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8308113969466171"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.457104682922363}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6570799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"S":["Y144-","R346S"],"nsp3":["T1269I"]},"labels":{"aa":"S: Y144-, R346S; nsp3: T1269I","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.424004077911377}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.32","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.946379661560059}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.31","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.428726673126221}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.459336757659912}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"nsp13":["T153I"]},"labels":{"aa":"nsp13: T153I"}}},{"name":"BQ.1.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"S":["R190T"],"nsp3":["V1847I"]},"labels":{"aa":"N: H300Q; S: R190T; nsp3: V1847I","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.914120197296143}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9833500385284424}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"nsp1":["G94C"]},"labels":{"aa":"nsp1: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.657703399658203}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"S":["R346T"],"nsp3":["V1786I"]},"labels":{"aa":"S: R346T; nsp3: V1786I","spike_mutations":"R346T"}}},{"name":"NODE_0001134","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"S":["L5F","Y144-"],"nsp1":["H110Y"],"nsp3":["E815D"]},"labels":{"aa":"S: L5F, Y144-; nsp1: H110Y; nsp3: E815D","spike_mutations":"L5F, Y144-"}}},{"name":"BQ.1.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001135","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"nsp2":["V447I"]},"labels":{"aa":"nsp2: V447I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0001136","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF3a":["R68I"],"nsp15":["P270L"],"nsp3":["V1339I"]},"labels":{"aa":"ORF3a: R68I; nsp15: P270L; nsp3: V1339I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0001137","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"nsp4":["L353F"]},"labels":{"aa":"nsp4: L353F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001138","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.009603977203369}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"nsp3":["V34A"]},"labels":{"aa":"nsp3: V34A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.111164569854736}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"NODE_0001139","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.710926055908203}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.710926055908203}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001140","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF7b":["A15S"],"nsp2":["S68N"]},"labels":{"aa":"ORF7b: A15S; nsp2: S68N"}}},{"name":"BQ.1.26.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.26.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"internal_56b3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.176206588745117}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.176206588745117}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8304200172424316}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0001143","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"S":["E619Q"],"nsp5":["L30I"]},"labels":{"aa":"S: E619Q; nsp5: L30I","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"nsp3":["L1035F"]},"labels":{"aa":"nsp3: L1035F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0001145","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"nsp2":["E172A"]},"labels":{"aa":"nsp2: E172A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6353800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6853534127590314"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":97,"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"EC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4688456058502197}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4688456058502197}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875691413879395}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"NODE_0001149","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66664"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9874397743924017"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"],"nsp1":["M85-"],"nsp14":["E364K"]},"labels":{"aa":"ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K; nsp1: M85-; nsp14: E364K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0001150","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"S":["F186-","K187-","N188Y"],"nsp1":["G82-","H83-","V84-"]},"labels":{"aa":"S: F186-, K187-, N188Y; nsp1: G82-, H83-, V84-","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6059300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":31},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:83-122"},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0821590912755812"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"],"nsp12":["V473F"],"nsp13":["T530A"],"nsp2":["L400F","L550F"]},"labels":{"aa":"ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A; nsp12: V473F; nsp13: T530A; nsp2: L400F, L550F","spike_mutations":"A484K, V486A"}}}]}]},{"name":"internal_dbfb","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"S":["Y144-"],"nsp13":["P504S"]},"labels":{"aa":"N: H300N; S: Y144-; nsp13: P504S","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5174000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6925976779449897"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"S":["K478R"],"nsp3":["G175D"]},"labels":{"aa":"S: K478R; nsp3: G175D","spike_mutations":"K478R"}}},{"name":"FB.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}}]}]},{"name":"internal_efa8","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.758645534515381}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"nsp13":["N268S"]},"labels":{"aa":"nsp13: N268S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.5464024543762207}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"nsp2":["A360V"]},"labels":{"aa":"nsp2: A360V"}}},{"name":"BQ.1.23","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4521589279174805}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.057005882263184}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.637411117553711}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp2":["S325F"]},"labels":{"aa":"S: Y144-; nsp2: S325F","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"S":["S256L","Q613H","V1164I"],"nsp13":["T588I"],"nsp2":["I216V"]},"labels":{"aa":"S: S256L, Q613H, V1164I; nsp13: T588I; nsp2: I216V","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0001155","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.39292049407959}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.39292049407959}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8915650844573975}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.535731792449951}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"S":["S494P"],"nsp10":["T115I"]},"labels":{"aa":"S: S494P; nsp10: T115I","spike_mutations":"S494P"}}},{"name":"BQ.1.1.17","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.149693012237549}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"nsp3":["S1455F"]},"labels":{"aa":"nsp3: S1455F"}}},{"name":"BQ.1.1.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.5311388969421387}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.19","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.22513484954834}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7449699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.073467254638672}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5921799999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8728938682420008"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.841221332550049}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.31","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8330674171447754}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.30","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.34","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.100788593292236}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.36","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.201074600219727}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.314393997192383}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.40","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"S":["Y144-","S704L"],"nsp2":["D23N"]},"labels":{"aa":"S: Y144-, S704L; nsp2: D23N","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.41","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9046711921691895}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"S":["K182I"],"nsp3":["A1711V"]},"labels":{"aa":"S: K182I; nsp3: A1711V","spike_mutations":"K182I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.068450927734375}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.47","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.249934673309326}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"S":["K147I"],"nsp4":["V434M"]},"labels":{"aa":"S: K147I; nsp4: V434M","spike_mutations":"K147I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7044405937194824}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.50","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.386298179626465}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"S":["Y144-","I210-"],"nsp12":["T801I"],"nsp2":["K489R"]},"labels":{"aa":"S: Y144-, I210-; nsp12: T801I; nsp2: K489R","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9954097270965576}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.56","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.530673980712891}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.57","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.360785007476807}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.55","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.861405849456787}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.58","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.378433704376221}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.60","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9752705097198486}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"nsp2":["L501F"]},"labels":{"aa":"nsp2: L501F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.371273994445801}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"S":["Y248H"],"nsp14":["V328I"]},"labels":{"aa":"S: Y248H; nsp14: V328I","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.64","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.916878700256348}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.276081562042236}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.67","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.056059837341309}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"S":["L176F"],"nsp3":["T1063I","T1336I"]},"labels":{"aa":"S: L176F; nsp3: T1063I, T1336I","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"nsp3":["V393I"]},"labels":{"aa":"nsp3: V393I"}}},{"name":"BQ.1.1.69","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.636171579360962}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"nsp14":["S503L"]},"labels":{"aa":"nsp14: S503L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8411405086517334}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"nsp3":["A85V"]},"labels":{"aa":"M: S212G; nsp3: A85V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.75","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04867000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.051732686328446"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2394514083862305}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp13":["A505V"]},"labels":{"aa":"S: Y144-; nsp13: A505V","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.7311859130859375}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.20283317565918}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.20283317565918}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.70602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.6625657081604}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"S":["G446S"],"nsp1":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"]},"labels":{"aa":"S: G446S; nsp1: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-","spike_mutations":"G446S"}}}]},{"name":"NODE_0001157","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.65602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.9605560302734375}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001158","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0001159","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.942479372024536}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.781022071838379}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.530292510986328}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"S":["G181R"],"nsp4":["F101L"]},"labels":{"aa":"S: G181R; nsp4: F101L","spike_mutations":"G181R"}}}]},{"name":"NODE_0001160","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.500977516174316}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"nsp3":["A1711T"]},"labels":{"aa":"nsp3: A1711T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"S":["K147E"],"nsp3":["A994T"]},"labels":{"aa":"S: K147E; nsp3: A994T","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"ET.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0001162","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"ES.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001163","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{"nuc":["C912A"],"nsp2":["S36Y"]},"labels":{"aa":"nsp2: S36Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74371"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.994874477386475}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"S":["D339N"],"nsp3":["A991T"]},"labels":{"aa":"S: D339N; nsp3: A991T","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.452545642852783}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"nsp12":["D109A"]},"labels":{"aa":"nsp12: D109A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.452545642852783}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.918569087982178}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bf35","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.695055961608887}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.695055961608887}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001166","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.212834358215332}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"nsp2":["H194Y"],"nsp3":["L151F"]},"labels":{"aa":"nsp2: H194Y; nsp3: L151F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.212834358215332}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66913"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9105813557217661"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"NODE_0001167","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9088196754455566}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9088196754455566}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.81001615524292}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"internal_edc4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8035850524902344}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"nsp14":["V115A"]},"labels":{"aa":"nsp14: V115A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8035850524902344}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6774299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001169","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001170","node_attrs":{"div":95,"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"ER.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{}}},{"name":"ER.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"ER.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF8":["P38S"],"S":["G257S"],"nsp2":["P181S"]},"labels":{"aa":"ORF8: P38S; S: G257S; nsp2: P181S","spike_mutations":"G257S"}}}]}]},{"name":"NODE_0001171","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.548947811126709}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"DR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001172","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6486213207244873}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.388934135437012}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.766948699951172}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"S":["H1083D"],"nsp2":["I472V"]},"labels":{"aa":"S: H1083D; nsp2: I472V","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.1.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"nsp14":["P429L"],"nsp2":["M135I"]},"labels":{"aa":"nsp14: P429L; nsp2: M135I"}}}]},{"name":"NODE_0001173","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001174","node_attrs":{"div":96,"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"EN.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}}]}]},{"name":"internal_1117","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504777908325195}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504777908325195}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.83009147644043}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_f9e1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"EA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478137493133545}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.34834999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.880706782961692"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.922173023223877}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_159a","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{}}},{"name":"ED.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"ED.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.188085079193115}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"nsp3":["D110Y"]},"labels":{"aa":"nsp3: D110Y"}}},{"name":"ED.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"ED.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.897581100463867}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}},{"name":"ED.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"ED.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6314659118652344}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF3a":["L108F"],"nsp2":["C253S"]},"labels":{"aa":"ORF3a: L108F; nsp2: C253S"}}}]},{"name":"NODE_0001178","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.167686462402344}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0001179","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"S":["P251L"],"nsp13":["P53S"]},"labels":{"aa":"S: P251L; nsp13: P53S","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.00280237197876}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.00280237197876}},"branch_attrs":{"mutations":{}}},{"name":"DT.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"DT.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.66092586517334}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"DT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.224767684936523}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}},{"name":"DT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"S":["S494P"],"nsp3":["S1682F"]},"labels":{"aa":"S: S494P; nsp3: S1682F","spike_mutations":"S494P"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.117684841156006}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4302690029144287}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0001183","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4922916889190674}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4922916889190674}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.18422269821167}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.131554126739502}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"nsp14":["V14I"]},"labels":{"aa":"nsp14: V14I"}}},{"name":"EE.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.522237777709961}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.840278148651123}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0001185","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.25513219833374}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0001186","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"S":["A701V"],"nsp15":["N28S"]},"labels":{"aa":"S: A701V; nsp15: N28S","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.65602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001187","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0001188","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"S":["Q613H"],"nsp2":["V258I"]},"labels":{"aa":"S: Q613H; nsp2: V258I","spike_mutations":"Q613H"}}}]},{"name":"NODE_0001189","node_attrs":{"div":101,"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":101,"Nextclade_pango":{"value":"BQ.1.1.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24659999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"EV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24659999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0001190","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.141762733459473}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.141762733459473}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"nsp12":["V128I"]},"labels":{"aa":"nsp12: V128I"}}},{"name":"EF.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"EF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.072010517120361}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"NODE_0001191","node_attrs":{"div":96,"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{}}},{"name":"internal_bc60","node_attrs":{"div":97,"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.138625144958496}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"EF.1.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"internal_e491","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.127105712890625}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.127105712890625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001194","node_attrs":{"div":99,"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0001195","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"nsp15":["P262L"],"nsp6":["V286I"]},"labels":{"aa":"nsp15: P262L; nsp6: V286I"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6995503902435303}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"nsp15":["D300N"]},"labels":{"aa":"nsp15: D300N"}}},{"name":"NODE_0001196","node_attrs":{"div":97,"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.508324146270752}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"nsp3":["V207L"]},"labels":{"aa":"nsp3: V207L"}},"children":[{"name":"DN.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"DN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.508324146270752}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-7.333120346069336}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0001197","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001198","node_attrs":{"div":99,"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"nsp3":["R1341W"]},"labels":{"aa":"nsp3: R1341W"}},"children":[{"name":"DN.1.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.05606"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8990816968865659"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"S":["Y453F"],"nsp2":["V541I"],"nsp3":["N1934S"]},"labels":{"aa":"S: Y453F; nsp2: V541I; nsp3: N1934S","spike_mutations":"Y453F"}}},{"name":"DN.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"DN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5626099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8771384492554943"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6722600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8744814686582322"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA*","ORF10":"MGYINVFAFPFTIYSLLLCRMNSRNYIAQVDVVNFNLT*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nsp1":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG","nsp10":"AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQ","nsp11":"SADAQSFLNGFAV","nsp12":"SADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ","nsp13":"AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQ","nsp14":"AENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQ","nsp15":"SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ","nsp16":"SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN","nsp2":"AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGG","nsp3":"APTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGG","nsp4":"KIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQ","nsp5":"SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ","nsp6":"SAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQ","nsp7":"SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQ","nsp8":"AIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQ","nsp9":"NNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-25","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/proteins/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/proteins/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/proteins/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF10":{"end":29674,"seqid":"profiles/clades/proteins/reference_seq.gb","start":29558,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/proteins/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/proteins/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/proteins/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nsp1":{"end":805,"seqid":"profiles/clades/proteins/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"nsp10":{"end":13441,"seqid":"profiles/clades/proteins/reference_seq.gb","start":13025,"strand":"+","type":"CDS"},"nsp11":{"end":13480,"seqid":"profiles/clades/proteins/reference_seq.gb","start":13442,"strand":"+","type":"CDS"},"nsp12":{"seqid":"profiles/clades/proteins/reference_seq.gb","strand":"+","type":"CDS","segments":[{"start":13442,"end":13468},{"start":13468,"end":16236}]},"nsp13":{"end":18039,"seqid":"profiles/clades/proteins/reference_seq.gb","start":16237,"strand":"+","type":"CDS"},"nsp14":{"end":19620,"seqid":"profiles/clades/proteins/reference_seq.gb","start":18040,"strand":"+","type":"CDS"},"nsp15":{"end":20658,"seqid":"profiles/clades/proteins/reference_seq.gb","start":19621,"strand":"+","type":"CDS"},"nsp16":{"end":21552,"seqid":"profiles/clades/proteins/reference_seq.gb","start":20659,"strand":"+","type":"CDS"},"nsp2":{"end":2719,"seqid":"profiles/clades/proteins/reference_seq.gb","start":806,"strand":"+","type":"CDS"},"nsp3":{"end":8554,"seqid":"profiles/clades/proteins/reference_seq.gb","start":2720,"strand":"+","type":"CDS"},"nsp4":{"end":10054,"seqid":"profiles/clades/proteins/reference_seq.gb","start":8555,"strand":"+","type":"CDS"},"nsp5":{"end":10972,"seqid":"profiles/clades/proteins/reference_seq.gb","start":10055,"strand":"+","type":"CDS"},"nsp6":{"end":11842,"seqid":"profiles/clades/proteins/reference_seq.gb","start":10973,"strand":"+","type":"CDS"},"nsp7":{"end":12091,"seqid":"profiles/clades/proteins/reference_seq.gb","start":11843,"strand":"+","type":"CDS"},"nsp8":{"end":12685,"seqid":"profiles/clades/proteins/reference_seq.gb","start":12092,"strand":"+","type":"CDS"},"nsp9":{"end":13024,"seqid":"profiles/clades/proteins/reference_seq.gb","start":12686,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-02-18","#531EA6"],["2021-02-21","#521EA7"],["2021-03-02","#4E20AC"],["2021-03-10","#4C24AF"],["2021-03-15","#4B26B1"],["2021-04-01","#472DB8"],["2021-04-07","#462FBA"],["2021-04-08","#4530BB"],["2021-04-13","#4432BD"],["2021-04-19","#4334BF"],["2021-04-20","#4335C0"],["2021-04-21","#4235C0"],["2021-04-23","#4236C1"],["2021-04-26","#4137C2"],["2021-04-30","#4039C4"],["2021-05-05","#403BC5"],["2021-05-13","#4040C6"],["2021-05-16","#4041C7"],["2021-05-21","#3F44C8"],["2021-05-25","#3F46C8"],["2021-05-26","#3F46C9"],["2021-06-04","#3F4BCA"],["2021-06-14","#3F50CC"],["2021-06-18","#3F53CD"],["2021-06-19","#3F53CD"],["2021-06-25","#3F56CE"],["2021-06-30","#3E59CF"],["2021-07-01","#3E59CF"],["2021-07-13","#3F5FD0"],["2021-07-22","#4064CF"],["2021-07-23","#4064CF"],["2021-07-26","#4066CF"],["2021-07-27","#4066CF"],["2021-07-28","#4067CF"],["2021-07-30","#4068CF"],["2021-08-02","#4169CF"],["2021-08-03","#416ACF"],["2021-08-04","#416ACF"],["2021-08-07","#416CCE"],["2021-08-09","#416DCE"],["2021-08-10","#416DCE"],["2021-08-12","#416ECE"],["2021-08-13","#416FCE"],["2021-08-16","#4270CE"],["2021-08-17","#4271CE"],["2021-08-18","#4271CE"],["2021-08-19","#4271CE"],["2021-08-22","#4273CE"],["2021-08-25","#4374CD"],["2021-08-27","#4375CD"],["2021-09-02","#4378CD"],["2021-09-03","#4379CD"],["2021-09-13","#447DCC"],["2021-09-20","#4580CA"],["2021-09-23","#4681C9"],["2021-09-24","#4682C9"],["2021-09-27","#4783C8"],["2021-09-29","#4783C8"],["2021-09-30","#4784C8"],["2021-10-04","#4885C7"],["2021-10-08","#4887C6"],["2021-10-11","#4988C5"],["2021-10-12","#4988C5"],["2021-10-18","#4A8BC3"],["2021-10-22","#4A8CC2"],["2021-10-25","#4B8DC2"],["2021-10-27","#4B8EC1"],["2021-10-28","#4B8FC1"],["2021-11-02","#4C91C0"],["2021-11-04","#4C91BF"],["2021-11-05","#4D92BF"],["2021-11-17","#4F96BC"],["2021-11-18","#4F96BB"],["2021-11-19","#4F97BB"],["2021-11-23","#5098BA"],["2021-11-24","#5098B9"],["2021-11-25","#5098B9"],["2021-11-29","#5199B7"],["2021-12-03","#529AB6"],["2021-12-07","#539BB4"],["2021-12-08","#539CB4"],["2021-12-10","#539CB3"],["2021-12-13","#549DB2"],["2021-12-14","#549DB2"],["2021-12-17","#559EB1"],["2021-12-19","#559FB0"],["2021-12-21","#569FAF"],["2021-12-22","#56A0AF"],["2021-12-26","#57A1AE"],["2021-12-28","#57A1AD"],["2022-01-01","#58A2AB"],["2022-01-05","#59A3AA"],["2022-01-07","#59A4A9"],["2022-02-16","#63AC99"],["2022-02-23","#65AD96"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-29","#6FB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-21","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Beta","#4067CF"],["Gamma","#4A8BC3"],["Delta","#5AA4A9"],["Epsilon","#6FB488"],["Eta","#8BBB69"],["Theta","#A9BD53"],["Iota","#C7B944"],["Kappa","#DDA93C"],["Lambda","#E68A35"],["Mu","#E35C2C"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","clade_who","clade_display","designation_date","designation_recency"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":true},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":false},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{},"labels":{"clade":"19A"}},"children":[{"name":"B","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{"ORF6":["D61L"],"S":["T19I"]},"labels":{"aa":"ORF6: D61L; S: T19I","spike_mutations":"T19I"}},"children":[{"name":"XAA","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A1610G","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C8247T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12445T","C12880T","C14408T","C15714T","C17410T","A18163G","A19356G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["N269D"],"nsp3":["K38R","S1265-","L1266I","S1843F"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: N269D; nsp3: K38R, S1265-, L1266I, S1843F; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAB","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.443575382232666}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17010T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XA","node_attrs":{"div":33,"Nextclade_pango":{"value":"XA"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T445C","T2019C","C3037T","C4999T","C6286T","C8090T","C9430T","A10323G","C13945T","C14408T","G20410A","G21255C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23208T","C23271A","A23403G","C23604A","C23709T","T24506G","G24914C","G25855T","C27972T","G28048T","A28095T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"N":["D3L","R203K","G204R","S235F"],"ORF3a":["D155Y"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","K68*","Y73C"],"S":["I19T","H69-","V70-","Y144-","N501Y","T549I","A570D","D614G","P681H","T716I","S982A","D1118H"],"nsp12":["P169S","P323L"],"nsp15":["E264K"],"nsp2":["M405T"],"nsp3":["L1791F"],"nsp5":["K90R"]},"labels":{"aa":"N: D3L, R203K, G204R, S235F; ORF3a: D155Y; ORF6: L61D; ORF8: Q27*, R52I, K68*, Y73C; S: I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H; nsp12: P169S, P323L; nsp15: E264K; nsp2: M405T; nsp3: L1791F; nsp5: K90R","spike_mutations":"I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H"}}},{"name":"XAF","node_attrs":{"div":65,"Nextclade_pango":{"value":"XAF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","T181I","V182F"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, T181I, V182F","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAE","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.17270999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","G4975A","A6390C","C9344T","A9424G","C9534T","C9803T","C9866T","C10029T","C10198T","G10447A","C10449A","C11249T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C","T29748C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","E1224A"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["R93C","S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, E1224A; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: R93C, S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAD","node_attrs":{"div":66,"Nextclade_pango":{"value":"XAD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.857146263122559}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","A1250G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["T149A"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: T149A; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.851975917816162}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15720T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25731T","C25810T","C26028T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["L140F"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: L140F; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAJ","node_attrs":{"div":72,"Nextclade_pango":{"value":"XAJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.647030830383301}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11674T","C12880T","C14408T","T15009C","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","A23535G","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N658S","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XAH","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.717092990875244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","G17242T","C17410T","A18163G","C18246T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33G","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["A336S","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33G, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: A336S, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAG","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.28093999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C2857T","C3037T","T5386G","C5585A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C12880T","C14408T","C15714T","C17410T","C17502T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","L956I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, L956I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAK","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15166"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3037714005953052"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4927T","T5386G","C7834T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C12880T","C14408T","C15240T","A18163G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","A22001G","T22200G","G22578A","G22599A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22942G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24863T","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","H69-","V70-","G142D","K147E","V213G","G339D","R346K","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N460K","S477N","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","H1101Y"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y; nsp1: S135R; nsp12: P323L; nsp14: I42V; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y"}}},{"name":"XAL","node_attrs":{"div":61,"Nextclade_pango":{"value":"XAL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","A2865G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","G21586T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L8F","L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","E49G","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, E49G, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K"}}},{"name":"XAM","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75567"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","T181I"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, T181I","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAN","node_attrs":{"div":70,"Nextclade_pango":{"value":"XAN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081246852874756}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7973A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","C17822T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","T27696C","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29666T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["L37F"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C","P529L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","L1752M"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: L37F; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C, P529L; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, L1752M; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAR","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.447500705718994}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21796T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","R78S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAP","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.9306466579437256}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C5407A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAQ","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","C9857T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23779T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAS","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.466667652130127}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAT","node_attrs":{"div":66,"Nextclade_pango":{"value":"XAT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","C10277T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19317T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25810T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["L140F","T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["L75F","P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: L140F, T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: L75F, P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAV","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.716916561126709}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C6606T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15960T","G17278T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["V348L","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","S1296F"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: V348L, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, S1296F; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAW","node_attrs":{"div":96,"Nextclade_pango":{"value":"XAW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91409"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.274687314409391"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C335T","G569A","T689C","G1048T","G1125A","C1973T","C3037T","G3246A","G4181T","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9676C","C10029T","A10323G","A11201G","G11330A","A11332G","C11866T","C13806T","C13994T","C14408T","C14585T","G15451A","C16466T","C17304T","C17550T","A17973G","G18525A","C19220T","C19290T","C20402T","G20493A","C21575T","C21618G","C21636T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","T22942A","G22992A","C22995A","A23013C","T23042C","A23055G","A23063T","T23075C","C23114T","A23403G","C23525T","C23604A","C23854A","G23948T","G24145A","A24424T","T24469A","C25000T","C25584T","A25592G","C26060T","C26270T","C26537T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28562A","G28646A","C28849T","C28873T","G28881T","G28916T","G29402T","C29635T","G29742T"],"E":["T9I"],"M":["Q19E","A63T"],"N":["D63G","G97S","A125T","R203M","G215C","D377Y"],"ORF3a":["K67R","T223I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["L5F","I19R","P25L","E156-","F157-","R158G","N211-","L212I","L242-","A243-","G339D","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","N460K","S477N","T478K","E484A","S494P","Q498R","N501Y","Y505H","D614G","H655Y","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["R24C","E102K","S142P"],"nsp12":["A185V","P323L","A382V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp15":["S261L"],"nsp2":["K81N","R107K"],"nsp3":["S176N","A488S","P778L","D1144N","P1228L","P1469S","A1570T"],"nsp4":["V167L","T492I"],"nsp5":["K90R"],"nsp6":["T77A","V120M"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: D63G, G97S, A125T, R203M, G215C, D377Y; ORF3a: K67R, T223I; ORF8: D119-, F120-; ORF9b: T60A; S: L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K; nsp1: R24C, E102K, S142P; nsp12: A185V, P323L, A382V, G671S; nsp13: P77L; nsp14: A394V; nsp15: S261L; nsp2: K81N, R107K; nsp3: S176N, A488S, P778L, D1144N, P1228L, P1469S, A1570T; nsp4: V167L, T492I; nsp5: K90R; nsp6: T77A, V120M","spike_mutations":"L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAU","node_attrs":{"div":70,"Nextclade_pango":{"value":"XAU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.173168659210205}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","T17407C","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAZ","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1912T","C2232T","C2790T","C3037T","C3317T","T3358C","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A476V"],"nsp3":["T24I","P200S","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A476V; nsp3: T24I, P200S, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XB","node_attrs":{"div":29,"Nextclade_pango":{"value":"XB"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-11-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.699317693710327}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C3688T","C3884T","C6633T","A7142G","A9614G","C9693T","A9754C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14408T","G15451A","C16466T","C21057T","T21615G","C21846T","A22036C","A23403G","C23604A","C23625T","T23765G","C24442T","C24642T","G26158-","T26159-","T26160-","A26161-","C26222T","C27389T","C27769T","G28048A","A28271-","A28330G","C28854T","A28910T"],"N":["S194L","N213Y"],"ORF3a":["V256-","N257-","P258I","M260I","E261I","P262I","T269I","P274I","L275I"],"ORF6":["L61D"],"ORF7b":["S5L"],"ORF8":["R52K"],"ORF9b":["D16G"],"S":["L18R","I19T","T95I","R158S","D614G","P681H","A688V","S735A","T1027I"],"nsp12":["P323L","G671S"],"nsp13":["P77L"],"nsp3":["P389S","A1305V","S1475G"],"nsp4":["T354A","A380V","R400S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: S194L, N213Y; ORF3a: V256-, N257-, P258I, M260I, E261I, P262I, T269I, P274I, L275I; ORF6: L61D; ORF7b: S5L; ORF8: R52K; ORF9b: D16G; S: L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I; nsp12: P323L, G671S; nsp13: P77L; nsp3: P389S, A1305V, S1475G; nsp4: T354A, A380V, R400S; nsp6: S106-, G107-, F108-","spike_mutations":"L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I"}}},{"name":"XBA","node_attrs":{"div":70,"Nextclade_pango":{"value":"XBA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20215999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.29808642936638835"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4181T","C6402T","C7124T","C8595T","C8986T","G9053T","C10029T","A11201G","A11332G","G13812T","C14408T","C14790T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","A22991G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","T26767C","G26959A","T27638C","A27663T","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","C28311T","A28461G","G28881A","G28882A","G28883C","G29402T","G29742T"],"M":["I82T","R146H"],"N":["P13L","D63G","R203K","G204R","D377Y"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["P10S","T60A"],"S":["L18F","I19R","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477D","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","T1117I"],"nsp1":["S135R"],"nsp12":["M124I","P323L","A529V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["T24I","A488S","P1228L","P1469S"],"nsp4":["T14I","V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T, R146H; N: P13L, D63G, R203K, G204R, D377Y; ORF3a: S26L; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: P10S, T60A; S: L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I; nsp1: S135R; nsp12: M124I, P323L, A529V, G671S; nsp13: P77L; nsp14: A394V; nsp3: T24I, A488S, P1228L, P1469S; nsp4: T14I, V167L, T492I; nsp6: T77A","spike_mutations":"L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I"}}},{"name":"XBD","node_attrs":{"div":82,"Nextclade_pango":{"value":"XBD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBE","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.574315547943115}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27800T","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["T127N","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: T127N, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBH","node_attrs":{"div":80,"Nextclade_pango":{"value":"XBH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.37244999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7528T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13730T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25157A","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28881A","G28882A","G28883C","A29510C","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","T29758C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","D1199N"],"nsp1":["S135R"],"nsp12":["A97V","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N; nsp1: S135R; nsp12: A97V, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N"}}},{"name":"XBG","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10116T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11665T","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","A24676G","C25000T","C25584T","C26060T","T26180C","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I","I263T"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["T21I","P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I, I263T; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: T21I, P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBN","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","A2863G","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","A19459G","C19554T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C25638T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","I474V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, I474V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBM","node_attrs":{"div":74,"Nextclade_pango":{"value":"XBM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","G19891A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23202T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27549T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","T547I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["D91N","T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: D91N, T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBP","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7303T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C12952T","C13965T","C14408T","C15277T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","T23773C","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","H613Y","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, H613Y, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBR","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1093T","G1440A","A1964G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","A5844G","C8597T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21077T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22855T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25471C","C25553T","T25569C","C25584T","G26031A","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["D27H","A54V","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["T140I"],"nsp2":["G212D","I387V"],"nsp3":["T24I","S403L","G489S","P822S","K1042R"],"nsp4":["L15F","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: D27H, A54V, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: T140I; nsp2: G212D, I387V; nsp3: T24I, S403L, G489S, P822S, K1042R; nsp4: L15F, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBQ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G14829T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","M463I","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, M463I, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBS","node_attrs":{"div":82,"Nextclade_pango":{"value":"XBS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T670G","C2790T","C2842T","C3037T","C3796T","C3809T","C3927T","G4184A","C4321T","C4586T","C5183T","C6982T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","T20748C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["G82-","H83-","V84-","M85V","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","L364F","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: G82-, H83-, V84-, M85V, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, L364F, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBT","node_attrs":{"div":81,"Nextclade_pango":{"value":"XBT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64255"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5037920175803539"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C829T","C1627T","C2790T","C3037T","A3207G","G4184A","G4288A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","G23587A","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","D163G","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, D163G, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBV","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32919999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8040G","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","G15957T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123A","A23223G","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24170G","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","P521T","E554G","D614G","H655Y","N679K","P681H","N764K","D796Y","I870V","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["T127N","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","D1774G"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: T127N, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, D1774G; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K"}}},{"name":"XBW","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22612C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","G29260A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBU","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74825"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["A51V","S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: A51V, S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBY","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5812T","C9344T","A9424G","C9532T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","G19962T","A20055G","C21054T","G21305A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T28137A","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["S82T"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["R216H"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: S82T; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: R216H; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XC","node_attrs":{"div":39,"Nextclade_pango":{"value":"XC"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5239T","T5514C","C6402T","C7124T","C8986T","G9053T","C10029T","A11201G","A11332G","C14408T","G15451A","C16466T","C19220T","C21618G","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22081T","T22917G","C22995A","A23403G","C23604G","G24410A","C25469T","T26767C","G27390T","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"M":["I82T"],"N":["D3L","R203K","G204R","S235F"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","Y73C"],"S":["I19R","T95I","G142D","E156-","F157-","R158G","Q173H","L452R","T478K","D614G","P681R","D950N"],"nsp12":["P323L","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["A488S","V932A","P1228L","P1469S"],"nsp4":["V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T; N: D3L, R203K, G204R, S235F; ORF3a: S26L; ORF6: L61D; ORF8: Q27*, R52I, Y73C; S: I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N; nsp12: P323L, G671S; nsp13: P77L; nsp14: A394V; nsp3: A488S, V932A, P1228L, P1469S; nsp4: V167L, T492I; nsp6: T77A","spike_mutations":"I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N"}}},{"name":"XBZ","node_attrs":{"div":80,"Nextclade_pango":{"value":"XBZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","T2954C","C3037T","G4184A","C4321T","C6040T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","C12880T","T14257C","C14408T","C15714T","G16935A","A17039G","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T21992-","A21993-","T21994-","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22858T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23086T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26428T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","C28770T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","V62F"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","T166I","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","Y144-","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["Y273H","P323L"],"nsp13":["M233I","N268S","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, V62F; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, T166I, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: Y273H, P323L; nsp13: M233I, N268S, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCA","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74825"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2062T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C5748A","C9344T","A9424G","T9454C","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19017T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21893A","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","C22747T","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","C23595T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","T25975C","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["S195P","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","D111N","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","T678I","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S","T1010N"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["A51V","S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: S195P, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S, T1010N; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: A51V, S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCC","node_attrs":{"div":97,"Nextclade_pango":{"value":"XCC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1545T","C2790T","C3037T","C3796T","C3857A","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A247V"],"nsp3":["T24I","Q380K","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A247V; nsp3: T24I, Q380K, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCB","node_attrs":{"div":75,"Nextclade_pango":{"value":"XCB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.41968"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","A11126G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C12880T","C14408T","C14724T","C15714T","C17410T","A18163G","G18651A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22302-","T22303-","T22304-","T22348A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27600T","C27807T","C27889T","A28271T","T28282C","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","S247-","Y248N","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["M52V","S106-","G107-","F108-"],"nsp8":["A74T"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: M52V, S106-, G107-, F108-; nsp8: A74T","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCE","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1931A","C2790T","T2954C","C3037T","G4184A","C4321T","C9344T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15810T","T15939C","T16342C","C17410T","T17859C","A18163G","G18811A","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","Y200C","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D258N"],"nsp15":["T112I"],"nsp2":["Q376K"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D258N; nsp15: T112I; nsp2: Q376K; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCD","node_attrs":{"div":91,"Nextclade_pango":{"value":"XCD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95377"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18006C","A18163G","A19173G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22203A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","G28077T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28681T","G28881A","G28882A","G28883C","C29367T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","P365L","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","R214H","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, P365L, S413R; ORF3a: T223I; ORF6: L61D; ORF8: V62L; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCG","node_attrs":{"div":87,"Nextclade_pango":{"value":"XCG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16254"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8170G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCM","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","G331T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","C5730T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T13560C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17661C","T17859C","A18163G","A18879G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24134A","A24373G","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","A29558G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["M1V"],"ORF3a":["A72T","A110V","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","F157L","N185D","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"],"nsp1":["Q22H","K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","T1004I","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: M1V; ORF3a: A72T, A110V, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K; nsp1: Q22H, K47R, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, T1004I, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}}},{"name":"XCL","node_attrs":{"div":101,"Nextclade_pango":{"value":"XCL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C7417T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15755G","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23093A","A23403G","C23525T","T23599G","C23604A","C23741T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25046T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","V511I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","P1162S"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S","S772C"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S; nsp1: K47R, S135R; nsp12: P323L, G671S, S772C; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S"}}},{"name":"XCJ","node_attrs":{"div":97,"Nextclade_pango":{"value":"XCJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C1063T","C2790T","C3037T","G4184A","C4321T","C6312T","A6616G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22843C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27431T","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28770T","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","T166I","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF7a":["A13V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","G181R","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","T1198I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, T166I, R203K, G204R, S413R; ORF3a: T223I; ORF7a: A13V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, T1198I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCK","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","T2128C","C2790T","C3037T","G3242A","G4184A","C4321T","C5512T","G5720A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12880T","C12970T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18096C","A18163G","A19326G","C19955T","G19962T","A20055G","G20060T","A21137G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","C26270T","G26529A","C26577G","G26709A","G26951C","C27807T","C27889T","C28163A","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","T29726-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I","V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I","S147I"],"nsp16":["K160R"],"nsp3":["T24I","G175S","G489S","G1001S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I, V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I, S147I; nsp16: K160R; nsp3: T24I, G175S, G489S, G1001S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XCP","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","C3622T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","C12880T","C14408T","A14634G","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","C19185T","A19326G","C19488T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","I189V"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, I189V; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCR","node_attrs":{"div":106,"Nextclade_pango":{"value":"XCR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C13405T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24373C","A24424T","T24469A","C25000T","A25359G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26708G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K","K1266R"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R"}}},{"name":"XCQ","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","A13187G","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","A22320G","C22388T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23757T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","T732I","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp10":["I55V"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp10: I55V; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K"}}},{"name":"XCN","node_attrs":{"div":116,"Nextclade_pango":{"value":"XCN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C337T","T670G","C1142T","C1471T","C1513T","C1686T","T2372C","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7318T","C8782T","G8849A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C14408T","C14790T","T14961C","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21807A","C21910T","G21987A","A22001G","T22016C","C22033A","A22121G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","T23332C","A23403G","C23453T","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27635T","C27807T","G27915T","C28253T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","P82H","G142D","K147E","W152R","F157L","K187E","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","P631S","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["L113F","A294V"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["V99M","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF7a: S81L; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: L113F, A294V; nsp3: T24I, S403L, G489S, P822S; nsp4: V99M, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCS","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17010T","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27669G","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","A29221G","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K"}}},{"name":"XCV","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","T5422C","C7044A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27065A","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28182G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","P1442H"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, S97G; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, P1442H; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCU","node_attrs":{"div":99,"Nextclade_pango":{"value":"XCU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8835"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1437T","C2790T","C3037T","T3478C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","C9891T","C10029T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","A17207G","A19890G","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","T23042C","A23055G","A23063T","T23075C","C23123A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","C26606T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28376A","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","A35T","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","D215H","A222V","L242-","A243-","S256L","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","S494P","Q498R","N501Y","Y505H","P521T","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["P77L","T127I","Y324C"],"nsp2":["S211F"],"nsp3":["T24I","T725I","P822L","S1286I","G1447S","V1458I","I1683V"],"nsp4":["A446V","T492I"],"nsp6":["V149A","T181I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, A35T, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: P77L, T127I, Y324C; nsp2: S211F; nsp3: T24I, T725I, P822L, S1286I, G1447S, V1458I, I1683V; nsp4: A446V, T492I; nsp6: V149A, T181I","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCY","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCZ","node_attrs":{"div":112,"Nextclade_pango":{"value":"XCZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","A15436G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22609G","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26735T","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28519T","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-","T79I"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","M666V","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-, T79I; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: D63N, P323L, M666V, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XCW","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","T6394C","G6536A","G8863T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T14305C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","G18636A","T18882C","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27513T","C27684T","C27807T","G27915T","T28034C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","I210-","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["Y289H","P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: Y289H, P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDB","node_attrs":{"div":97,"Nextclade_pango":{"value":"XDB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","G15982A","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S","V848I"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S, V848I; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XD","node_attrs":{"div":65,"Nextclade_pango":{"value":"XD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.029110000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.17203353628663032"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","A1321C","C3037T","G4181T","C6402T","C7124T","C7851T","A8723G","C8986T","G9053T","C10029T","A11201G","A11332G","C14407T","C14408T","T15264C","G15451A","C16466T","C19220T","C21618G","G21641T","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25667T","G25855T","T26767C","T27638C","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G28916T","G29402T","G29540A","G29645T","G29742T"],"M":["I82T"],"N":["D63G","R203M","G215C","D377Y"],"ORF10":["V30L"],"ORF3a":["S92L","D155Y"],"ORF6":["L61D"],"ORF7a":["V82A","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["I19R","A27S","T95I","G142D","E156-","F157-","R158G","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323F","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp2":["E172D"],"nsp3":["A488S","P1228L","P1469S","A1711V"],"nsp4":["I57V","V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T; N: D63G, R203M, G215C, D377Y; ORF10: V30L; ORF3a: S92L, D155Y; ORF6: L61D; ORF7a: V82A, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: T60A; S: I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323F, G671S; nsp13: P77L; nsp14: A394V; nsp2: E172D; nsp3: A488S, P1228L, P1469S, A1711V; nsp4: I57V, V167L, T492I; nsp6: T77A","spike_mutations":"I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XDC","node_attrs":{"div":108,"Nextclade_pango":{"value":"XDC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2110T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","C15763T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21036T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: D63N, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDE","node_attrs":{"div":104,"Nextclade_pango":{"value":"XDE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","T21363C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26612G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29535T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["S122F"],"nsp3":["T24I","G489S","P1261Q","T1465I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["P80L"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: S122F; nsp3: T24I, G489S, P1261Q, T1465I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: P80L","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDF","node_attrs":{"div":107,"Nextclade_pango":{"value":"XDF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C335T","A405G","T670G","C2790T","C3037T","T3453C","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","G27666T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","T28382C","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","S37P","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["R24C","K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","V245A","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, S37P, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF7a: E91D; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: R24C, K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, V245A, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDG","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C547T","T670G","C1758T","C2790T","C3037T","G4184A","C4321T","T4579A","T4690C","T4930C","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","T16905C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","A23598G","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","A25744G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28754T","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","L161F","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["I118V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679R","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A318V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, L161F, R203K, G204R, S413R; ORF10: S23F; ORF3a: I118V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A318V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDH","node_attrs":{"div":97,"Nextclade_pango":{"value":"XDH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","T2992A","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","T4744C","C5183T","T7477C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C13335T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp10":["A104V"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","D91E","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp10: A104V; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, D91E, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDJ","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C8947T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","A10861G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G29081T","A29510C","C29625T","A29700G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","V270L","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","F157L","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, V270L, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDM","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","T24046C","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["T85A","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp2":["D155G"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: T85A, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp2: D155G; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDL","node_attrs":{"div":110,"Nextclade_pango":{"value":"XDL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2650T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","C17410T","T17859C","C17976T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","T24903C","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","C28253A","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","F120L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","I1114T"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, F120L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T; nsp1: K47R, S135R; nsp12: D63N, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T"}}},{"name":"XDN","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","C280T","T670G","C897A","C1762A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","C12880T","T13339C","C14408T","C14425T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D","F319L"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D, F319L; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K"}}},{"name":"XDS","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","G598A","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29409T","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","C29836T"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","T379I","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, T379I, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDT","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C1601T","C2790T","C3037T","G3431T","G4184A","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9344T","A9424G","C9534T","C9661T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","T25496C","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27014A","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29778A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["I35T","T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","H69-","V70-","V127F","G142D","Y144-","R158G","N211-","L212I","V213G","L216F","A222V","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D","L266F"],"nsp3":["T24I","V238L","G489S","N1708S","A1892T"],"nsp4":["I27V","L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp7":["V33A"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: I35T, T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D, L266F; nsp3: T24I, V238L, G489S, N1708S, A1892T; nsp4: I27V, L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp7: V33A; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}}},{"name":"XDU","node_attrs":{"div":111,"Nextclade_pango":{"value":"XDU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.63761"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9475349114594978"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","C3177T","C3587T","C3944A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","C22674T","T22679C","C22686T","A22688G","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26078T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I","T229I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","S371F","S373P","S375F","T376A","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","P153L","H290Y","Q409K","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I, T229I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, P153L, H290Y, Q409K, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDY","node_attrs":{"div":127,"Nextclade_pango":{"value":"XDY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","G19669A","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","C22858T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["G17R","T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: G17R, T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15919"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","T1030C","A2127G","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14120T","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21301T","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A263V","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P227L","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["P215S"],"nsp2":["A31D","Y441C"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P227L, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: P215S; nsp2: A31D, Y441C; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XDZ","node_attrs":{"div":114,"Nextclade_pango":{"value":"XDZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7086T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","C23557T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S","T1456I"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S, T1456I; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XE","node_attrs":{"div":62,"Nextclade_pango":{"value":"XE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C14599T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XEB","node_attrs":{"div":119,"Nextclade_pango":{"value":"XEB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEA","node_attrs":{"div":122,"Nextclade_pango":{"value":"XEA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.41162"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2268340125514634"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","C13255T","T13339C","A13712G","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R"],"nsp12":["K91R","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","D695E","K1155R","N1708S","A1711S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R; nsp12: K91R, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, D695E, K1155R, N1708S, A1711S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XED","node_attrs":{"div":124,"Nextclade_pango":{"value":"XED"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":17.361},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XED"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9430T","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","A13308G","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25350T","C25584T","C26060T","C26270T","G26529C","C26577G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L","P1263L"],"nsp1":["S135R","T170I"],"nsp10":["K95R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L; nsp1: S135R, T170I; nsp10: K95R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L"}}},{"name":"XEG","node_attrs":{"div":119,"Nextclade_pango":{"value":"XEG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":950.694},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","A2443G","C2790T","C2939T","C3037T","C3876T","G4184A","C4234T","C4321T","G6536A","A6646G","T6747C","C7819G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T10723C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","G19327T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","C23191T","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V","A430S"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","P74S","A386V","G489S","G1273S","L1343S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V, A430S; nsp15: T112I; nsp2: A31D; nsp3: T24I, P74S, A386V, G489S, G1273S, L1343S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEE","node_attrs":{"div":125,"Nextclade_pango":{"value":"XEE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.013909816741943}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","G17334T","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","H146Q","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","T1303A","T1465I","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, T1303A, T1465I, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XF","node_attrs":{"div":57,"Nextclade_pango":{"value":"XF"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.623017311096191}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","T1390C","A2255G","C3037T","G4181T","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29632T"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp2":["I484V"],"nsp3":["A488S","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp2: I484V; nsp3: A488S, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XEF","node_attrs":{"div":124,"Nextclade_pango":{"value":"XEF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.12538"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":34.028},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7268345560655398"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","G4255T","C4321T","C4683T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","N211-","L212I","V213G","L216F","H245N","A264D","I332V","L335S","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","A655V","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, A655V, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XH","node_attrs":{"div":65,"Nextclade_pango":{"value":"XH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.385257720947266}},"branch_attrs":{"mutations":{"nuc":["C241T","T902C","C904A","G1244A","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28435T","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-","P51L"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["C33R","G147S"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-, P51L; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: C33R, G147S; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XG","node_attrs":{"div":69,"Nextclade_pango":{"value":"XG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","T5386G","C5672T","G5924A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19855G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["I79V","T112I"],"nsp3":["K38R","P985S","V1069I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: I79V, T112I; nsp3: K38R, P985S, V1069I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XJ","node_attrs":{"div":65,"Nextclade_pango":{"value":"XJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","G11287-","T11288-","C11289-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106F","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106F, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XK","node_attrs":{"div":59,"Nextclade_pango":{"value":"XK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-3.62446"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A16064G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23403G","C23525T","T23599G","C23604A","A23767G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L","Q875R"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","R810C","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L, Q875R; nsp14: I42V; nsp15: T112I; nsp3: K38R, R810C, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XL","node_attrs":{"div":68,"Nextclade_pango":{"value":"XL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","C875T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G14229A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["L24F"],"nsp3":["K38R","V1069I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: L24F; nsp3: K38R, V1069I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XM","node_attrs":{"div":60,"Nextclade_pango":{"value":"XM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.202031135559082}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XP","node_attrs":{"div":59,"Nextclade_pango":{"value":"XP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.023200000000000068"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3616394203564539"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.596989154815674}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24190C","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","C26880A","A27259C","C27807T","A28254-","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3G","Q19E","A63T","L120I"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF6":["L61D"],"ORF8":["I121-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T, L120I; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF6: L61D; ORF8: I121-; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XN","node_attrs":{"div":67,"Nextclade_pango":{"value":"XN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.3213419914245605}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","G10986A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["R5K","S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: R5K, S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XQ","node_attrs":{"div":66,"Nextclade_pango":{"value":"XQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.557600498199463}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A17615G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C","K460R"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C, K460R; nsp14: I42V; nsp15: T112I; nsp3: K38R; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XS","node_attrs":{"div":61,"Nextclade_pango":{"value":"XS"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.812868118286133}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5365T","C6196T","C6402T","C7124T","C8986T","G9053T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21595T","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["A488S","P1228L","P1469S"],"nsp4":["V167L","T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp3: A488S, P1228L, P1469S; nsp4: V167L, T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XT","node_attrs":{"div":63,"Nextclade_pango":{"value":"XT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.9682207107543945}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13994T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21786T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G75V","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["A185V","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: A185V, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XR","node_attrs":{"div":69,"Nextclade_pango":{"value":"XR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C4893T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G13295A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25524G","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","C27131T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp10":["D91N"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","T725I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp10: D91N; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, T725I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XU","node_attrs":{"div":67,"Nextclade_pango":{"value":"XU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.814977645874023}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C16887T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XW","node_attrs":{"div":68,"Nextclade_pango":{"value":"XW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","C10507T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12756T","C12880T","C14408T","C15714T","G16020T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T24I"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T24I","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XV","node_attrs":{"div":62,"Nextclade_pango":{"value":"XV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.5818281173706055}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3583T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XY","node_attrs":{"div":68,"Nextclade_pango":{"value":"XY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A1585G","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11049C","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","A22351G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26058T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["V26A","L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: V26A, L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XZ","node_attrs":{"div":64,"Nextclade_pango":{"value":"XZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.045811176300049}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","G20398A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I","E260K"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I, E260K; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"internal_XBK","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBK.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":105,"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","A1124G","C1973T","A2163C","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16856G","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","G25947C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27741T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["Q185H","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","D207G","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R107G","E453A"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: Q185H, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, D207G, R392C; nsp14: I42V; nsp15: T112I; nsp2: R107G, E453A; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCH.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":105,"Nextclade_pango":{"value":"XCH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1684T","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7051T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19886G","C19955T","A20055G","C20320T","A20741G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22115G","A22190G","T22200G","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","T24073C","C24134A","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["A72T","A110V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","N185D","I210V","V213G","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["K89R","T112I","H234Y"],"nsp16":["Q28R"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: A72T, A110V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: K89R, T112I, H234Y; nsp16: Q28R; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}},"children":[{"name":"XCT.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"XCT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":105,"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["T85A","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp2":["D155G"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: T85A, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp2: D155G; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDA.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"XDA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":105,"Nextclade_pango":{"value":"XDA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":127,"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18657T","C18894T","C19716T","C19955T","A20055G","C21618T","C21622T","G21624C","C21627A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25006T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28291A","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G28884C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204P","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P3H","P10S","E27-","N28-","A29-"],"S":["R21T","T22N","L24-","P25-","P26-","A27S","S50L","F59S","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204P, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P3H, P10S, E27-, N28-, A29-; S: R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"XEC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":29.34},"designation_date":{"value":"2024-08-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"S":["K182R"],"nsp2":["A419T"],"nsp9":["L42F"]},"labels":{"aa":"S: K182R; nsp2: A419T; nsp9: L42F","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":127,"Nextclade_pango":{"value":"XEC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":34.028},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4006A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17067C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","T26012G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["F207C","T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: F207C, T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCF","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"XCF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XCF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XCF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R","T170I"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R, T170I; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"S":["E1092D"],"nsp2":["H208Y","L217P"]},"labels":{"aa":"S: E1092D; nsp2: H208Y, L217P","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2668T","C2790T","C3037T","G4184A","C4321T","C6896T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"S":["F59S","R346T"],"nsp3":["A1120S"]},"labels":{"aa":"S: F59S, R346T; nsp3: A1120S","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF8":["E92K"],"S":["F456L"],"nsp16":["A83D"],"nsp3":["A1324V"]},"labels":{"aa":"ORF8: E92K; S: F456L; nsp16: A83D; nsp3: A1324V","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"nsp14":["L366F"],"nsp6":["L185F"]},"labels":{"aa":"nsp14: L366F; nsp6: L185F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G3446A","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","A20379G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","A243T","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, A243T, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBL","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBL.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}},{"name":"XBL.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","C7420T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A27980G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","T29023C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDQ","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":114,"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.493661403656006}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.3","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDQ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"XDQ.2","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"S":["N487D"],"nsp4":["F39C"]},"labels":{"aa":"S: N487D; nsp4: F39C","spike_mutations":"N487D"}}},{"name":"NODE_0000019","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.296817302703857}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.296817302703857}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1471T","C2445T","C2790T","C3037T","G3072A","G4184A","C4321T","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10189T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C12880T","C14408T","C15714T","C17410T","C17678T","A18163G","C18252T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22020C","T22054G","T22200G","C22295A","G22332A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893G","A22910G","C22916A","T22942G","G22992A","C22995A","G23012A","A23013G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25896T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","M153T","N164K","V213G","H245N","G257D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444R","N450D","L452M","N460K","S477N","T478K","E484R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C","T481M"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["T547I"],"nsp3":["T24I","C118Y","G489S","I896T","M1351V","T1356I","A1766V","T1830I"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp7":["Q63R"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C, T481M; nsp14: I42V; nsp15: T112I; nsp2: T547I; nsp3: T24I, C118Y, G489S, I896T, M1351V, T1356I, A1766V, T1830I; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp7: Q63R","spike_mutations":"L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBJ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000021","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"nsp4":["K165N"]},"labels":{"aa":"nsp4: K165N"}}},{"name":"XBJ.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"S":["F456L","T572I"],"nsp14":["T524A"]},"labels":{"aa":"S: F456L, T572I; nsp14: T524A","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDD.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","C23277T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","T572I","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.2","node_attrs":{"div":125,"Nextclade_pango":{"value":"XDK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","C22928T","A23598G","C27297T"],"S":["L456F","K679R"]},"labels":{"aa":"S: L456F, K679R","spike_mutations":"L456F, K679R"}}},{"name":"XDK.3","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"nsp5":["F134L"]},"labels":{"aa":"nsp5: F134L"}}},{"name":"XDK.5","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.635818004608154}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"internal_0964eaa1","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"XDK.4.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDK.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T"],"nsp14":["P203S"],"nsp2":["T528I"],"nsp3":["A264V"]},"labels":{"aa":"nsp14: P203S; nsp2: T528I; nsp3: A264V"}}}]},{"name":"internal_C29762T","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, Q1201K","spike_mutations":"R237K, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G11596A","C18664T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.2","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.803860664367676}},"branch_attrs":{"mutations":{"nuc":["G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"NODE_0000032","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":129,"Nextclade_pango":{"value":"XDK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0469899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","T18664C","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"XDK.1","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["C241T","G625T","T670G","C1627T","C2790T","C3037T","T3339C","G4184A","C4321T","C6070T","C8692T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K120N","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","V207A","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K120N, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, V207A, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBF","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000034","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.10"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"nsp2":["V94I"]},"labels":{"aa":"nsp2: V94I"}}},{"name":"XBF.5","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.3351006507873535}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.6","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"nsp8":["V44A"]},"labels":{"aa":"nsp8: V44A"}}},{"name":"XBF.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"nsp2":["H237Y"]},"labels":{"aa":"nsp2: H237Y"}}},{"name":"XBF.9","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.9"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"nsp13":["S80G"]},"labels":{"aa":"nsp13: S80G"}}},{"name":"NODE_0000035","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"S":["P621S"],"nsp3":["G337C"]},"labels":{"aa":"S: P621S; nsp3: G337C","spike_mutations":"P621S"}}}]},{"name":"NODE_0000036","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"nsp1":["N120K"]},"labels":{"aa":"N: T379I; nsp1: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBF.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"S":["T323I"],"nsp14":["Q354E"]},"labels":{"aa":"S: T323I; nsp14: Q354E","spike_mutations":"T323I"}}}]},{"name":"NODE_0000037","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBF.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"S":["P621S"],"nsp1":["K141-","S142-","F143-"]},"labels":{"aa":"S: P621S; nsp1: K141-, S142-, F143-","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C12880T","C14408T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","A21623G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23423T","C23525T","T23599G","C23604A","C23679T","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","C26681T","T26767C","G26959A","C27575G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"M":["I82T","R146H"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["T61S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L18F","I19R","R21G","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","P621S","H655Y","N679K","P681H","A706V","N764K","D796Y","Q954H","N969K","T1117I"],"nsp1":["S135R"],"nsp12":["P323L","A529V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["T24I","G489S","P1469S"],"nsp4":["T14I","V167L","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T21I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: S26L; ORF6: L61D; ORF7a: T61S; ORF9b: P10S, E27-, N28-, A29-; S: L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I; nsp1: S135R; nsp12: P323L, A529V, G671S; nsp13: P77L; nsp14: A394V; nsp3: T24I, G489S, P1469S; nsp4: T14I, V167L, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T21I","spike_mutations":"L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000039","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":79,"Nextclade_pango":{"value":"XAY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"nsp14":["D345Y"]},"labels":{"aa":"nsp14: D345Y"}}},{"name":"NODE_0000040","node_attrs":{"div":80,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.995934963226318}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"nsp6":["Y196C"]},"labels":{"aa":"nsp6: Y196C"}},"children":[{"name":"XAY.2","node_attrs":{"div":80,"Nextclade_pango":{"value":"XAY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.995934963226318}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000041","node_attrs":{"div":81,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.154902458190918}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"nsp4":["I363T"]},"labels":{"aa":"nsp4: I363T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":82,"Nextclade_pango":{"value":"XAY.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000204563140869}},"branch_attrs":{"mutations":{"nuc":["C657T"],"nsp1":["A131V"]},"labels":{"aa":"nsp1: A131V"}}},{"name":"NODE_0000042","node_attrs":{"div":82,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.154902458190918}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":83,"Nextclade_pango":{"value":"XAY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796263694763184}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.699412822723389}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"nsp1":["R124C"],"nsp2":["N267S"]},"labels":{"aa":"nsp1: R124C; nsp2: N267S"}}}]}]}]},{"name":"NODE_0000043","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.521972179412842}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"S":["D253G"],"nsp1":["D48N"],"nsp4":["I289V"],"nsp5":["Q83K"]},"labels":{"aa":"S: D253G; nsp1: D48N; nsp4: I289V; nsp5: Q83K","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.521972179412842}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF9b":["S50L"],"nsp6":["T77I"]},"labels":{"aa":"ORF9b: S50L; nsp6: T77I"}}},{"name":"NODE_0000044","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"S":["R346T"],"nsp3":["K1290N"]},"labels":{"aa":"S: R346T; nsp3: K1290N","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF7a":["S61T"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"ORF7a: S61T; nsp1: G82-, H83-, V84-, M85V"}}},{"name":"NODE_0000045","node_attrs":{"div":87,"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XAY.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.0969953536987305}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000046","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"GL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.778546333312988}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"nsp3":["P822S"]},"labels":{"aa":"nsp3: P822S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000047","node_attrs":{"div":89,"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.697271823883057}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"GL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6888599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752889267417711"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.495382308959961}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"GL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF9b":["R13L"],"nsp2":["S543P"]},"labels":{"aa":"ORF9b: R13L; nsp2: S543P"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["S122F"],"nsp3":["T24I","G489S","P1261Q","T1465I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["P80L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: S122F; nsp3: T24I, G489S, P1261Q, T1465I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: P80L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000049","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":125,"Nextclade_pango":{"value":"XDV.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.10"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"S":["G181V"],"nsp9":["T35I"]},"labels":{"aa":"S: G181V; nsp9: T35I","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.11"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.3"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.5","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDV.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14808999999999992"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5359962252743784"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.5"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.4","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.4"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.6","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDV.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.6"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"nsp3":["E391D","T611I","V965I"]},"labels":{"aa":"nsp3: E391D, T611I, V965I"}}},{"name":"XDV.1.8","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.8"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000050","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"S":["R346T"],"nsp4":["L353F"]},"labels":{"aa":"N: I292T; S: R346T; nsp4: L353F","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"XDV.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26874999999999993"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":6.25},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.8051577060608006"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"S":["K462R"],"nsp6":["L260F"]},"labels":{"aa":"S: K462R; nsp6: L260F","spike_mutations":"K462R"}}}]},{"name":"NODE_0000051","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"nsp4":["D217N"]},"labels":{"aa":"nsp4: D217N"}},"children":[{"name":"XDV.1.7.1","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDV.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"2-3 weeks"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"S":["T22N","V62F"],"nsp2":["L501F"]},"labels":{"aa":"S: T22N, V62F; nsp2: L501F","spike_mutations":"T22N, V62F"}}},{"name":"XDV.1.7","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000052","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"nsp3":["T1379I"]},"labels":{"aa":"nsp3: T1379I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDV.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20783000000000001"},"designation_recency":{"value":"2-3 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5422010449483097"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","C9891T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23670T","C23854A","G23948T","A24424T","T24469A","C25000T","C25854T","T26767C","T26819C","T27718C","C27752T","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["T60A"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","P209L","L212S","D215H","A222V","L242-","A243-","S256L","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N703I","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["P77L","T127I"],"nsp3":["T24I","T725I","P822L","S1286I","V1458I"],"nsp4":["A446V"],"nsp6":["V149A","T181I"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: T60A; S: P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: P77L, T127I; nsp3: T24I, T725I, P822L, S1286I, V1458I; nsp4: A446V; nsp6: V149A, T181I","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6871599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000054","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000055","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"S":["K97R"],"nsp4":["V102I"]},"labels":{"aa":"S: K97R; nsp4: V102I","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":72,"Nextclade_pango":{"value":"XBC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6871599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF8":["D34-"],"nsp2":["A318V"]},"labels":{"aa":"ORF8: D34-; nsp2: A318V"}}},{"name":"XBC.2.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.58838"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.44507236664312827"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF8":["A15T"],"S":["K444T"],"nsp3":["G489S"]},"labels":{"aa":"ORF8: A15T; S: K444T; nsp3: G489S","spike_mutations":"K444T"}}}]},{"name":"NODE_0000056","node_attrs":{"div":69,"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"S":["L452M"],"nsp2":["S211F"]},"labels":{"aa":"S: L452M; nsp2: S211F","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":69,"Nextclade_pango":{"value":"XBC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000057","node_attrs":{"div":70,"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"nsp4":["T492I"]},"labels":{"aa":"nsp4: T492I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"S":["G184S"],"nsp1":["G82-","H83-","V84-"],"nsp12":["T803P"],"nsp8":["P10S","V130A"]},"labels":{"aa":"S: G184S; nsp1: G82-, H83-, V84-; nsp12: T803P; nsp8: P10S, V130A","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":74,"Nextclade_pango":{"value":"XBC.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"nsp2":["T528I"],"nsp3":["A1179V"]},"labels":{"aa":"nsp2: T528I; nsp3: A1179V"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"nsp12":["T141I"]},"labels":{"aa":"nsp12: T141I"}}},{"name":"XBC.1.2","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}}]},{"name":"NODE_0000059","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF8":["V114L"],"nsp1":["K141-","S142-","F143-"],"nsp6":["I50T"]},"labels":{"aa":"ORF8: V114L; nsp1: K141-, S142-, F143-; nsp6: I50T"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000060","node_attrs":{"div":78,"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"XBC.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11213999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48837241784414276"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF3a":["P262L"],"ORF7a":["P34L"],"nsp1":["R124C"]},"labels":{"aa":"ORF3a: P262L; ORF7a: P34L; nsp1: R124C"}}}]}]},{"name":"NODE_0000061","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF7a":["T14I"],"S":["K444T","K478R"],"nsp13":["Y324C"]},"labels":{"aa":"ORF7a: T14I; S: K444T, K478R; nsp13: Y324C","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":79,"Nextclade_pango":{"value":"XBC.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"S":["T299I"],"nsp3":["V188I"]},"labels":{"aa":"S: T299I; nsp3: V188I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000062","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000063","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp12":["S768N"],"nsp2":["Q275K"],"nsp3":["V1243A"],"nsp9":["T34I"]},"labels":{"aa":"ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-; nsp1: G82-, H83-, V84-, M85-, V86-; nsp12: S768N; nsp2: Q275K; nsp3: V1243A; nsp9: T34I"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"nsp3":["E115V"]},"labels":{"aa":"nsp3: E115V"}},"children":[{"name":"KD.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"KD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF3a":["T151I"],"nsp6":["M92L"],"nsp7":["M75I"]},"labels":{"aa":"ORF3a: T151I; nsp6: M92L; nsp7: M75I"}}},{"name":"KD.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"KD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7857899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"KD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":82,"Nextclade_pango":{"value":"KD.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"nsp2":["K214R","L550F"],"nsp3":["T147I"]},"labels":{"aa":"nsp2: K214R, L550F; nsp3: T147I"}}}]}]}]},{"name":"NODE_0000065","node_attrs":{"div":83,"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"S":["R346S","M452R"],"nsp13":["I333V"],"nsp2":["A510V"],"nsp3":["C296F","H1841Y"]},"labels":{"aa":"S: R346S, M452R; nsp13: I333V; nsp2: A510V; nsp3: C296F, H1841Y","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":83,"Nextclade_pango":{"value":"XBC.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"nsp3":["D9N"]},"labels":{"aa":"nsp3: D9N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"nsp3":["V299I"]},"labels":{"aa":"nsp3: V299I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBC.1.6.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF7a":["Q90*"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp12":["R721C"]},"labels":{"aa":"ORF7a: Q90*; nsp1: G82-, H83-, V84-, M85V; nsp12: R721C"}}},{"name":"NODE_0000066","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"GT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000067","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"JT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47217000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7550301657183831"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"S":["V445A"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"S: V445A; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":85,"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":85,"Nextclade_pango":{"value":"XBC.1.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000069","node_attrs":{"div":88,"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"nsp3":["T779I","A1305V"]},"labels":{"aa":"nsp3: T779I, A1305V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"HW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.63844"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420325830319254"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","clade":"22F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBB","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000071","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000072","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"nsp1":["G82D"]},"labels":{"aa":"nsp1: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"nsp4":["V103M"],"nsp6":["V182F"]},"labels":{"aa":"N: T49I; nsp4: V103M; nsp6: V182F"}}},{"name":"NODE_0000073","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3064099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26627999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0810114368008295"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"S":["L5F","T470N"],"nsp3":["N833K"]},"labels":{"aa":"S: L5F, T470N; nsp3: N833K","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000074","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4179558753967285}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000075","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000076","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"nsp2":["K454N"],"nsp5":["K90R"]},"labels":{"aa":"nsp2: K454N; nsp5: K90R"}}},{"name":"XBB.8.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"nsp14":["I474V"]},"labels":{"aa":"nsp14: I474V"}},"children":[{"name":"XBB.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.83066463470459}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}}},{"name":"NODE_0000079","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"S":["V1122L"],"nsp12":["A529T"]},"labels":{"aa":"S: V1122L; nsp12: A529T","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.122056484222412}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.122056484222412}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.165473937988281}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.636689186096191}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.256861209869385}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"S":["S486P"],"nsp3":["V1209I"]},"labels":{"aa":"S: S486P; nsp3: V1209I","spike_mutations":"S486P"}}},{"name":"NODE_0000081","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.454007148742676}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}},{"name":"XBB.2.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.454007148742676}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000082","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"nsp6":["R93H"]},"labels":{"aa":"nsp6: R93H"}},"children":[{"name":"XBB.2.7.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65097"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"S":["Y453F","K478Q"],"nsp2":["E70D"]},"labels":{"aa":"S: Y453F, K478Q; nsp2: E70D","spike_mutations":"Y453F, K478Q"}}},{"name":"XBB.2.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000083","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.832684516906738}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000084","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"ORF10":["Q29*"],"S":["Q613H"]},"labels":{"aa":"ORF10: Q29*; S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35217"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35217"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF7a":["A13V"],"S":["S486P","P521S"],"nsp13":["P36S"],"nsp3":["G1273S"]},"labels":{"aa":"ORF7a: A13V; S: S486P, P521S; nsp13: P36S; nsp3: G1273S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF7a":["H47Y"],"S":["D80Y"],"nsp12":["A250T"]},"labels":{"aa":"ORF7a: H47Y; S: D80Y; nsp12: A250T","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.14"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"nsp3":["Q180H"]},"labels":{"aa":"nsp3: Q180H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.2.3.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0750199999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2567103717994188"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.18"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.20","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.20"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.21","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.2.3.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.21"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"S":["T883I"],"nsp1":["R135S"],"nsp4":["D279N"]},"labels":{"aa":"S: T883I; nsp1: R135S; nsp4: D279N","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.22"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84876"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.456076622009277}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"nsp8":["T145I"]},"labels":{"aa":"nsp8: T145I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.9"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.92117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.92117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"nsp3":["T1004I"]},"labels":{"aa":"nsp3: T1004I"}},"children":[{"name":"JA.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"JA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13359999999999994"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"JU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84789"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0527558336884004"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90647"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.90196418762207}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"nsp4":["D144N"]},"labels":{"aa":"nsp4: D144N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84876"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.16"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89912"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.17"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"nsp10":["I55V"]},"labels":{"aa":"nsp10: I55V"}},"children":[{"name":"JS.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"JS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"S":["T323I"],"nsp6":["M100I"]},"labels":{"aa":"S: T323I; nsp6: M100I","spike_mutations":"T323I"}}},{"name":"JS.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"JS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"XBB.2.3.15","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"S":["G184V"],"nsp3":["P968L"]},"labels":{"aa":"S: G184V; nsp3: P968L","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":105,"Nextclade_pango":{"value":"JY.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"S":["K478T","E654K"],"nsp16":["K182R"],"nsp5":["P241L"]},"labels":{"aa":"S: K478T, E654K; nsp16: K182R; nsp5: P241L","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.88039"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.88039"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.972652912139893}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"nsp8":["R75K"]},"labels":{"aa":"nsp8: R75K"}},"children":[{"name":"GM.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GM.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89932"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736186906064397"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"S":["N388K"],"nsp4":["S336L"]},"labels":{"aa":"S: N388K; nsp4: S336L","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"S":["K478R"],"nsp2":["A403V"],"nsp6":["L260F"]},"labels":{"aa":"S: K478R; nsp2: A403V; nsp6: L260F","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"nsp4":["I23V"]},"labels":{"aa":"nsp4: I23V"}},"children":[{"name":"HG.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"HG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"S":["S255F"],"nsp3":["S1455F"]},"labels":{"aa":"S: S255F; nsp3: S1455F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"HG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":102,"Nextclade_pango":{"value":"HG.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"HG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HG.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"internal_aa639495","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7709600000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0079043361863298"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF3a":["I179V"],"nsp8":["L169F"]},"labels":{"aa":"ORF3a: I179V; nsp8: L169F"}}}]},{"name":"NODE_0000102","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.295290470123291}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":110,"Nextclade_pango":{"value":"GS.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"S":["A845S"],"nsp1":["I114V"],"nsp12":["A581V"],"nsp13":["H164Y"],"nsp3":["K394-","P395-","F396-","S1813P"],"nsp4":["V403I"]},"labels":{"aa":"S: A845S; nsp1: I114V; nsp12: A581V; nsp13: H164Y; nsp3: K394-, P395-, F396-, S1813P; nsp4: V403I","spike_mutations":"A845S"}}}]},{"name":"NODE_0000103","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.607783794403076}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GS.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"S":["R190S"],"nsp15":["F279L"]},"labels":{"aa":"S: R190S; nsp15: F279L","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":100,"Nextclade_pango":{"value":"GS.7"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"nsp2":["L24I"]},"labels":{"aa":"nsp2: L24I"}},"children":[{"name":"GS.7.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"GS.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"S":["E180Q"],"nsp2":["G339S"]},"labels":{"aa":"S: E180Q; nsp2: G339S","spike_mutations":"E180Q"}}},{"name":"GS.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"GS.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"S":["Q218H"],"nsp3":["T1004I"]},"labels":{"aa":"S: Q218H; nsp3: T1004I","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.4"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"nsp2":["A1T"]},"labels":{"aa":"nsp2: A1T"}},"children":[{"name":"GS.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GS.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"S":["G184V"],"nsp3":["R1341W"]},"labels":{"aa":"S: G184V; nsp3: R1341W","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"HH.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"nsp3":["T970M"]},"labels":{"aa":"nsp3: T970M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"HH.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF8":["T26I"],"S":["K147N"],"nsp2":["L113I"],"nsp9":["P57S"]},"labels":{"aa":"ORF8: T26I; S: K147N; nsp2: L113I; nsp9: P57S","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":106,"Nextclade_pango":{"value":"HH.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF8":["G8R"],"S":["K478R"],"nsp3":["D117E"]},"labels":{"aa":"ORF8: G8R; S: K478R; nsp3: D117E","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HH.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000111","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"internal_bb69915a","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"nsp4":["T214I"]},"labels":{"aa":"nsp4: T214I"}},"children":[{"name":"HH.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}},{"name":"HH.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HH.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"nsp1":["D48Y"]},"labels":{"aa":"nsp1: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"HH.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"S":["K478R"],"nsp16":["T140I"],"nsp5":["S81F"]},"labels":{"aa":"S: K478R; nsp16: T140I; nsp5: S81F","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":98,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":99,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"nsp13":["I480V"]},"labels":{"aa":"nsp13: I480V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"GE.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"nsp5":["P96S"]},"labels":{"aa":"nsp5: P96S"}}},{"name":"GE.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"GE.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"internal_d2763520","node_attrs":{"div":100,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.00916051864624}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"nsp2":["G481S"]},"labels":{"aa":"nsp2: G481S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"S":["L118I"],"nsp9":["A8T"]},"labels":{"aa":"S: L118I; nsp9: A8T","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF7a":["P99S"],"S":["N148T"],"nsp10":["V116A"],"nsp3":["P1103S"]},"labels":{"aa":"ORF7a: P99S; S: N148T; nsp10: V116A; nsp3: P1103S","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"GE.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.70075"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.986824739722089"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp12":["A526V"],"nsp14":["D375E"]},"labels":{"aa":"ORF6: L61H; ORF7b: F19L; S: S408N; nsp1: G82-, H83-, V84-, M85-, V86-; nsp12: A526V; nsp14: D375E","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":107,"Nextclade_pango":{"value":"GE.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF3a":["S195C"],"S":["A376S","R478T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF3a: S195C; S: A376S, R478T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GE.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":111,"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"KT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":112,"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KT.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":114,"Nextclade_pango":{"value":"KT.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"nsp15":["N277S"]},"labels":{"aa":"nsp15: N277S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.2036452293396}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"nsp15":["V320L"],"nsp3":["P153S"]},"labels":{"aa":"nsp15: V320L; nsp3: P153S"}}},{"name":"GJ.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"S":["I1114S"],"nsp12":["T803I"]},"labels":{"aa":"S: I1114S; nsp12: T803I","spike_mutations":"I1114S"}}},{"name":"GJ.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"GJ.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13359999999999994"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"S":["F456L"],"nsp3":["T73I","Y996C"]},"labels":{"aa":"M: G6S; S: F456L; nsp3: T73I, Y996C","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"S":["E183K"],"nsp14":["P203S"]},"labels":{"aa":"S: E183K; nsp14: P203S","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.5"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GJ.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"S":["S255F"],"nsp2":["A360V"],"nsp8":["A21V"]},"labels":{"aa":"S: S255F; nsp2: A360V; nsp8: A21V","spike_mutations":"S255F"}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF8":["E106Q"],"nsp9":["I65V"]},"labels":{"aa":"ORF8: E106Q; nsp9: I65V"}},"children":[{"name":"GJ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"S":["A222V"],"nsp3":["V1097I","N1410S"]},"labels":{"aa":"N: R319H; S: A222V; nsp3: V1097I, N1410S","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":103,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"nsp13":["V187I"]},"labels":{"aa":"nsp13: V187I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"GJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GJ.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF9b":["I5T"],"S":["K478R"],"nsp3":["G334C"]},"labels":{"aa":"ORF9b: I5T; S: K478R; nsp3: G334C","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"nsp3":["H101Y"]},"labels":{"aa":"nsp3: H101Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"GJ.1.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF8":["G8V"],"S":["S255F"],"nsp3":["C1342Y"]},"labels":{"aa":"ORF8: G8V; S: S255F; nsp3: C1342Y","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"nsp13":["S74P"]},"labels":{"aa":"nsp13: S74P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.6","node_attrs":{"div":105,"Nextclade_pango":{"value":"GJ.1.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4524970054626465}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.5","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}}]},{"name":"internal_18110768","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89912"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":108,"Nextclade_pango":{"value":"JE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"JE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":109,"Nextclade_pango":{"value":"JE.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":110,"Nextclade_pango":{"value":"JE.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"JE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"KH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF7a":["V71L"],"S":["E554K"],"nsp1":["R135S"]},"labels":{"aa":"N: L13F; ORF7a: V71L; S: E554K; nsp1: R135S","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.0628252029418945}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.0628252029418945}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13558"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"ORF10":["A8V"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"ORF10: A8V; S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49564"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"S":["A484T"],"nsp3":["P1469S"]},"labels":{"aa":"S: A484T; nsp3: P1469S","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"S":["S486P"],"nsp13":["L138I"]},"labels":{"aa":"S: S486P; nsp13: L138I","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0545"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.33"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"],"nsp1":["V84-","M85-"],"nsp3":["T847I","Q1668P"]},"labels":{"aa":"ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E; nsp1: V84-, M85-; nsp3: T847I, Q1668P","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89405"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.49"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"S":["T346S"],"nsp1":["R124C"]},"labels":{"aa":"S: T346S; nsp1: R124C","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.541812419891357}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.20"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF3a":["A72V"],"nsp10":["P59T"]},"labels":{"aa":"ORF3a: A72V; nsp10: P59T"}}},{"name":"XBB.1.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.9722600000000003"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.48"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.19.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"S":["P521S"],"nsp3":["T1251I"]},"labels":{"aa":"S: P521S; nsp3: T1251I","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"S":["D936G"],"nsp3":["T820I","P1228S"]},"labels":{"aa":"S: D936G; nsp3: T820I, P1228S","spike_mutations":"D936G"}}},{"name":"GW.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"GW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"nsp1":["S100N"],"nsp5":["N274S"]},"labels":{"aa":"nsp1: S100N; nsp5: N274S"}}},{"name":"GW.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"GW.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"nsp5":["M17I"]},"labels":{"aa":"nsp5: M17I"}}},{"name":"XBB.1.19.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":103,"Nextclade_pango":{"value":"GW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF9b":["T79I"],"nsp2":["D84N"]},"labels":{"aa":"N: M322V; ORF9b: T79I; nsp2: D84N"}},"children":[{"name":"GW.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"GW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"GW.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"S":["F456L"],"nsp16":["K160R"]},"labels":{"aa":"S: F456L; nsp16: K160R","spike_mutations":"F456L"}}}]},{"name":"NODE_0000141","node_attrs":{"div":108,"Nextclade_pango":{"value":"GW.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"S":["L455F","F456L","K478I"],"nsp2":["S122F"],"nsp3":["P1261Q"],"nsp9":["P80L"]},"labels":{"aa":"N: P80S; S: L455F, F456L, K478I; nsp2: S122F; nsp3: P1261Q; nsp9: P80L","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"GW.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"GW.5.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"S":["G184A","A475V"],"nsp2":["I514V"]},"labels":{"aa":"S: G184A, A475V; nsp2: I514V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":116,"Nextclade_pango":{"value":"GW.5.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"],"nsp1":["P62L"]},"labels":{"aa":"ORF3a: G172C; ORF6: L61H; S: F79S, A475V; nsp1: P62L","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"GW.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.1","node_attrs":{"div":121,"Nextclade_pango":{"value":"KE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.2","node_attrs":{"div":121,"Nextclade_pango":{"value":"KE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"S":["S704L"],"nsp3":["A1766V"]},"labels":{"aa":"S: S704L; nsp3: A1766V","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":118,"Nextclade_pango":{"value":"KE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"nsp12":["T739I"],"nsp6":["L72S"]},"labels":{"aa":"nsp12: T739I; nsp6: L72S"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.1273951530456543}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86729"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.21"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"S":["S486A"],"nsp3":["K429R"]},"labels":{"aa":"S: S486A; nsp3: K429R","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2602599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.27"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"S":["K478R","A890V"],"nsp12":["N88I"]},"labels":{"aa":"S: K478R, A890V; nsp12: N88I","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.29"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"S":["A292S"],"nsp6":["G48C","L260F"]},"labels":{"aa":"S: A292S; nsp6: G48C, L260F","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.36"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.40"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF3a":["P104S"],"S":["Y453F"],"nsp2":["G339S"],"nsp3":["L1791F"]},"labels":{"aa":"ORF3a: P104S; S: Y453F; nsp2: G339S; nsp3: L1791F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.88502836227417}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"S":["V608I"],"nsp3":["K233N"]},"labels":{"aa":"S: V608I; nsp3: K233N","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"S":["Q146K","L216F"],"nsp3":["C55F","H1702Q"]},"labels":{"aa":"S: Q146K, L216F; nsp3: C55F, H1702Q","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393089294433594}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"S":["Y453F"],"nsp12":["D260N","T643A"],"nsp2":["S36F"],"nsp4":["A69V"]},"labels":{"aa":"S: Y453F; nsp12: D260N, T643A; nsp2: S36F; nsp4: A69V","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"S":["Q613H","E1202Q"],"nsp2":["T434I"]},"labels":{"aa":"S: Q613H, E1202Q; nsp2: T434I","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.727348327636719}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.727348327636719}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"S":["Q564E","N856K"],"nsp3":["T1368A"]},"labels":{"aa":"S: Q564E, N856K; nsp3: T1368A","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000148","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"nsp2":["A360V"]},"labels":{"aa":"nsp2: A360V"}},"children":[{"name":"XBB.1.15.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.15","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_234859ae","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.930898189544678}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.930898189544678}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_8d12","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.231898784637451}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.37.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.231898784637451}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_97a057d5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.254012107849121}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"S":["S486P"],"nsp3":["A1803V"]},"labels":{"aa":"S: S486P; nsp3: A1803V","spike_mutations":"S486P"}}},{"name":"XBB.1.43","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.254012107849121}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_fcda1063","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.44.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF3a":["S195F"],"S":["S486P"],"nsp2":["A360V"]},"labels":{"aa":"ORF3a: S195F; S: S486P; nsp2: A360V","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.039512634277344}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.45.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.45","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.039512634277344}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000155","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"S":["Y453F","K478R"],"nsp2":["P129L"],"nsp3":["W1414C"]},"labels":{"aa":"S: Y453F, K478R; nsp2: P129L; nsp3: W1414C","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF3a":["V197L"],"S":["E554K"],"nsp3":["H342Y"],"nsp6":["L19F"]},"labels":{"aa":"ORF3a: V197L; S: E554K; nsp3: H342Y; nsp6: L19F","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.31.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"nsp3":["A231V"]},"labels":{"aa":"nsp3: A231V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"S":["S486P"],"nsp6":["V26F"]},"labels":{"aa":"S: S486P; nsp6: V26F","spike_mutations":"S486P"}}},{"name":"XBB.1.4.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF9b":["R47C"],"S":["S486P","H681R"],"nsp13":["V169I"]},"labels":{"aa":"N: A50V; ORF9b: R47C; S: S486P, H681R; nsp13: V169I","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"S":["E554K"],"nsp13":["P47L"]},"labels":{"aa":"S: E554K; nsp13: P47L","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF8":["C90F"],"S":["K182I"],"nsp3":["G171C"]},"labels":{"aa":"ORF8: C90F; S: K182I; nsp3: G171C","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.34.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9296858310699463}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.30"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.753546237945557}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}}},{"name":"XBB.1.39","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.39"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.072872638702393}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"nsp4":["V103M"]},"labels":{"aa":"nsp4: V103M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"nsp1":["E148D"]},"labels":{"aa":"nsp1: E148D"}},"children":[{"name":"XBB.1.32.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF7a":["A50S"],"S":["Y453F"],"nsp16":["L100I"],"nsp2":["L462F"],"nsp3":["T1303I"]},"labels":{"aa":"ORF7a: A50S; S: Y453F; nsp16: L100I; nsp2: L462F; nsp3: T1303I","spike_mutations":"Y453F"}}},{"name":"XBB.1.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.579292297363281}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05231"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"S":["L335S"],"nsp15":["S161I"]},"labels":{"aa":"S: L335S; nsp15: S161I","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.856406211853027}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.095174789428711}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp3":["G1440C"]},"labels":{"aa":"nsp1: G82-, H83-, V84-, M85V; nsp3: G1440C"}}},{"name":"FW.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"nsp3":["D1809N"]},"labels":{"aa":"nsp3: D1809N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.28.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.856406211853027}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345422744750977}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF6":["F2-"],"S":["A701V"],"nsp1":["V84-","M85-"]},"labels":{"aa":"ORF6: F2-; S: A701V; nsp1: V84-, M85-","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:3-62"},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345422744750977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":99,"Nextclade_pango":{"value":"FW.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF7a":["E121*"],"S":["N148T"],"nsp10":["A32T"],"nsp13":["I525L"],"nsp3":["S20N"]},"labels":{"aa":"ORF7a: E121*; S: N148T; nsp10: A32T; nsp13: I525L; nsp3: S20N","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:3-62"},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF6":["-2F","L61H"],"S":["A684T"],"nsp3":["S1467F"],"nsp5":["K90R"]},"labels":{"aa":"ORF6: -2F, L61H; S: A684T; nsp3: S1467F; nsp5: K90R","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"S":["-24L","S27-","H69-","V70-"],"nsp3":["T1198I"]},"labels":{"aa":"S: -24L, S27-, H69-, V70-; nsp3: T1198I","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"FP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"S":["F186S"],"nsp4":["V315I"]},"labels":{"aa":"S: F186S; nsp4: V315I","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":100,"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF3a":["W149C"],"S":["K478R"],"nsp2":["I513T"],"nsp3":["T133A"]},"labels":{"aa":"ORF3a: W149C; S: K478R; nsp2: I513T; nsp3: T133A","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FP.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":101,"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FP.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7388600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"FP.2.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"S":["P521S"],"nsp1":["F143Y"]},"labels":{"aa":"S: P521S; nsp1: F143Y","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9296858310699463}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"nsp2":["P129L"]},"labels":{"aa":"nsp2: P129L"}}},{"name":"XBB.1.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.35"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"nsp1":["V89A"]},"labels":{"aa":"nsp1: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.46"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"nsp3":["C296F"]},"labels":{"aa":"nsp3: C296F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF8":["Q18*"],"nsp3":["T943I","C1362Y"],"nsp4":["I91V"]},"labels":{"aa":"ORF8: Q18*; nsp3: T943I, C1362Y; nsp4: I91V"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.47.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"S":["A260V","S486P","V1122G"],"nsp2":["K489N"]},"labels":{"aa":"S: A260V, S486P, V1122G; nsp2: K489N","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"S":["S486P"],"nsp1":["K120R"]},"labels":{"aa":"S: S486P; nsp1: K120R","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05408"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"XBB.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000173","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"nsp2":["K81N"]},"labels":{"aa":"nsp2: K81N"}},"children":[{"name":"XBB.1.24.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.24.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"XBB.1.24.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.24.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.696725368499756}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"nsp3":["D1761G"]},"labels":{"aa":"nsp3: D1761G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.696725368499756}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357577800750732}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357577800750732}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":96,"Nextclade_pango":{"value":"FE.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF3a":["F207C"],"S":["F456L"],"nsp3":["S315G"]},"labels":{"aa":"ORF3a: F207C; S: F456L; nsp3: S315G","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":98,"Nextclade_pango":{"value":"FE.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"S":["K1086R"],"nsp3":["Q173H"]},"labels":{"aa":"S: K1086R; nsp3: Q173H","spike_mutations":"K1086R"}}},{"name":"FE.1.1.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000178","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"nsp3":["T181I"]},"labels":{"aa":"nsp3: T181I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":102,"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"HE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"S":["L335S","R403K","S486P"],"nsp15":["S161I"],"nsp2":["T223I"]},"labels":{"aa":"S: L335S, R403K, S486P; nsp15: S161I; nsp2: T223I","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65784"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.41.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6066099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1099290580037755"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"S":["S494P"],"nsp12":["A195T"]},"labels":{"aa":"S: S494P; nsp12: A195T","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.41.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65784"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":101,"Nextclade_pango":{"value":"JW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"S":["K478R"],"nsp2":["L217F"]},"labels":{"aa":"S: K478R; nsp2: L217F","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"S":["Q14K"],"nsp13":["Y277H"]},"labels":{"aa":"S: Q14K; nsp13: Y277H","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"JW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.41.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":102,"Nextclade_pango":{"value":"JC.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"nsp3":["P402L"]},"labels":{"aa":"N: H300Y; nsp3: P402L"}},"children":[{"name":"JC.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"JC.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JC.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"S":["Q173K"],"nsp1":["G98S"]},"labels":{"aa":"S: Q173K; nsp1: G98S","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}},{"name":"JC.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"JC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.43418"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"S":["H339R"],"nsp3":["V238L"]},"labels":{"aa":"S: H339R; nsp3: V238L","spike_mutations":"H339R"}}},{"name":"JC.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"JC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"ORF10":["M1I"],"S":["N703I"]},"labels":{"aa":"ORF10: M1I; S: N703I","spike_mutations":"N703I"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"nsp2":["L289F"]},"labels":{"aa":"nsp2: L289F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"nsp2":["A518S"]},"labels":{"aa":"nsp2: A518S"}}},{"name":"NODE_0000188","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"GA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"nsp2":["G548C"]},"labels":{"aa":"nsp2: G548C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"nsp15":["V185I"]},"labels":{"aa":"nsp15: V185I"}},"children":[{"name":"GA.10","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"nsp12":["V128I"]},"labels":{"aa":"nsp12: V128I"}}},{"name":"GA.10.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GA.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","G13822A","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"],"nsp12":["V128I"],"nsp14":["K423R"],"nsp2":["I188V","A596V"],"nsp3":["F396S","S1285F"]},"labels":{"aa":"M: H125Y, R146H; ORF9b: T95M; S: L455F, F456L, K478R; nsp12: V128I; nsp14: K423R; nsp2: I188V, A596V; nsp3: F396S, S1285F","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}}},{"name":"GA.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"nsp12":["A195V"]},"labels":{"aa":"nsp12: A195V"}}},{"name":"GA.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T6640C","G23222A","A25927T"],"ORF3a":["I179F"],"S":["E554K"]},"labels":{"aa":"ORF3a: I179F; S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GA.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80721"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"S":["N450D","K478R"],"nsp1":["M85-"]},"labels":{"aa":"S: N450D, K478R; nsp1: M85-","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"nsp3":["I1320V"]},"labels":{"aa":"nsp3: I1320V"}},"children":[{"name":"GA.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GA.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"ORF10":["Q29*"],"S":["T250I","K478R"]},"labels":{"aa":"ORF10: Q29*; S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000192","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"nsp3":["I733V"]},"labels":{"aa":"nsp3: I733V"}}},{"name":"GA.8.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GA.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.96117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"],"nsp15":["A117V"]},"labels":{"aa":"M: H125Y; ORF8: C102F; S: K182E, S494P, E554K; nsp15: A117V","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.7"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"nsp2":["E442G"],"nsp3":["T611I"]},"labels":{"aa":"nsp2: E442G; nsp3: T611I"}},"children":[{"name":"GA.7","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GA.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90647"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000194","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"S":["K356T"],"nsp3":["N262D","S1735F"]},"labels":{"aa":"S: K356T; nsp3: N262D, S1735F","spike_mutations":"K356T"}},"children":[{"name":"GA.4.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"GA.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"S":["K558N","G1124S"],"nsp15":["P262S"]},"labels":{"aa":"S: K558N, G1124S; nsp15: P262S","spike_mutations":"K558N, G1124S"}}},{"name":"GA.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000195","node_attrs":{"div":101,"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GA.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"S":["F186L","L585F"],"nsp13":["E261D"]},"labels":{"aa":"S: F186L, L585F; nsp13: E261D","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000196","node_attrs":{"div":108,"Nextclade_pango":{"value":"GA.4.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GA.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GA.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":112,"Nextclade_pango":{"value":"GA.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"nsp3":["V521I"]},"labels":{"aa":"N: K370N; nsp3: V521I"}}},{"name":"GA.4.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"GA.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF6":["E13Q"],"S":["T572I"],"nsp2":["G339S"]},"labels":{"aa":"ORF6: E13Q; S: T572I; nsp2: G339S","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7987143993377686}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7987143993377686}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.110"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.110"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.2336883544921875}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"nsp8":["T187I"]},"labels":{"aa":"nsp8: T187I"}}},{"name":"XBB.1.5.23","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.23"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"nsp9":["P80L"]},"labels":{"aa":"nsp9: P80L"}}},{"name":"XBB.1.5.22","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.22"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"S":["Q146K"],"nsp3":["E680A"]},"labels":{"aa":"S: Q146K; nsp3: E680A","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.45","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.45"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.43","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.43"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.57","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.57"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.58"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF6":["D6G"],"S":["Q146K","S704L"],"nsp14":["V83I"]},"labels":{"aa":"ORF6: D6G; S: Q146K, S704L; nsp14: V83I","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.87"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.87"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"S":["K478T"],"nsp3":["M770K","E815K"]},"labels":{"aa":"S: K478T; nsp3: M770K, E815K","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.874494791030884}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"GF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062406063079834}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.874494791030884}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000199","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-2.2820098400115967}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.10"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.755892753601074}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"S":["F456L"],"nsp14":["A119V"]},"labels":{"aa":"S: F456L; nsp14: A119V","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.101"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.101"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.70775842666626}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.104"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.104"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.086434841156006}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.105"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.105"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"S":["K304N"],"nsp13":["Y253H"],"nsp15":["V127I"],"nsp3":["S93F"]},"labels":{"aa":"S: K304N; nsp13: Y253H; nsp15: V127I; nsp3: S93F","spike_mutations":"K304N"}}},{"name":"XBB.1.5.109","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.109"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.109"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"S":["F456L"],"nsp2":["T474A"]},"labels":{"aa":"S: F456L; nsp2: T474A","spike_mutations":"F456L"}}},{"name":"XBB.1.5.12","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.12"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.645435094833374}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.11"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9643361568450928}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"nsp2":["G221S"]},"labels":{"aa":"nsp2: G221S"}}},{"name":"XBB.1.5.18","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.18"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.739724636077881}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"nsp3":["T1482I"]},"labels":{"aa":"nsp3: T1482I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.003551483154297}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.28"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8692514896392822}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.26","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.406291484832764}},"branch_attrs":{"mutations":{"nuc":["C920T"]}}},{"name":"XBB.1.5.31","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.31"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8875620365142822}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.29","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41404999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.29"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"S":["A348V"],"nsp15":["S261L"],"nsp16":["A34V"],"nsp6":["L239F"]},"labels":{"aa":"S: A348V; nsp15: S261L; nsp16: A34V; nsp6: L239F","spike_mutations":"A348V"}}},{"name":"XBB.1.5.35","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.35"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062806606292725}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.34","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.34"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.282310962677002}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"nsp3":["T936I"]},"labels":{"aa":"nsp3: T936I"}}},{"name":"XBB.1.5.33","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.33"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.6427886486053467}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.36"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.249703407287598}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95377"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.40"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.2360076904296875}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.51"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.949040174484253}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF3a":["A54V"],"nsp4":["D246A"]},"labels":{"aa":"ORF3a: A54V; nsp4: D246A"}}},{"name":"XBB.1.5.52","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.52"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.848769187927246}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.54"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.59"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.107088088989258}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"S":["F456L"],"nsp4":["S59P"]},"labels":{"aa":"S: F456L; nsp4: S59P","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.62"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.189932823181152}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.63"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.754556179046631}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.64"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.171535968780518}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.67"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.776366710662842}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.66"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.803469181060791}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"nsp2":["G339S"]},"labels":{"aa":"nsp2: G339S"}}},{"name":"XBB.1.5.69","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.69"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.275020122528076}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"nsp4":["V180I"]},"labels":{"aa":"nsp4: V180I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.75"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.359410762786865}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.79"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.655872344970703}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.80"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.80"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.275026798248291}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.82"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91194"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.82"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.86","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.86"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.079804420471191}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"nsp4":["G105S"]},"labels":{"aa":"nsp4: G105S"}}},{"name":"XBB.1.5.85","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.85"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.85"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.97"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.97"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.438870429992676}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.99","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.99"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.99"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.521791934967041}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"nsp3":["V304A","T1303I"]},"labels":{"aa":"nsp3: V304A, T1303I"}}},{"name":"XBB.1.5.98","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.98"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.98"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000200","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.663036823272705}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"nsp12":["V257F"]},"labels":{"aa":"nsp12: V257F"}},"children":[{"name":"EM.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.39544677734375}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.663036823272705}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.362810134887695}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.174376964569092}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.362810134887695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.762918472290039}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"S":["I666V"],"nsp2":["T223I"]},"labels":{"aa":"S: I666V; nsp2: T223I","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.809896945953369}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.762918472290039}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.015121936798096}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"HA.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.779919624328613}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"nsp4":["G105S"],"nsp6":["M143V"]},"labels":{"aa":"nsp4: G105S; nsp6: M143V"}}},{"name":"XBB.1.5.108","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.108"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.108"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF9b":["V30M"],"S":["K304N"],"nsp14":["A23S"]},"labels":{"aa":"N: G30-, -33D; ORF9b: V30M; S: K304N; nsp14: A23S","spike_mutations":"K304N"}}}]},{"name":"NODE_0000204","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.923110008239746}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.943153381347656}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.923110008239746}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.120842456817627}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29094"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1023732112409157"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41123000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.120842456817627}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.741388320922852}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"nsp3":["T350I"]},"labels":{"aa":"nsp3: T350I"}},"children":[{"name":"HQ.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"HQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.92"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.741388320922852}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.495574951171875}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"HY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.282982349395752}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.100"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.495574951171875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7761480808258057}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"JK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.8508501052856445}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7761480808258057}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.523141384124756}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"JZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.971319675445557}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"S":["F456L"],"nsp14":["L157F"]},"labels":{"aa":"S: F456L; nsp14: L157F","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.107"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.523141384124756}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9941704273223877}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"KM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"],"nsp6":["T127A"]},"labels":{"aa":"N: A155V; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R; nsp6: T127A","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9941704273223877}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.398263931274414}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.50"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"S":["P621S"],"nsp3":["A1279V"]},"labels":{"aa":"N: T49I; S: P621S; nsp3: A1279V","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48403999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.71"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.380550861358643}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"S":["V511I"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"S: V511I; nsp1: G82-, H83-, V84-, M85V","spike_mutations":"V511I"}}}]},{"name":"NODE_0000212","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.277703762054443}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"nsp2":["K142R"]},"labels":{"aa":"nsp2: K142R"}},"children":[{"name":"GC.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"GC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9061"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.03073601411565"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.990260601043701}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"S":["T323I"],"nsp10":["F89L"]},"labels":{"aa":"S: T323I; nsp10: F89L","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.277703762054443}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000213","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.037090301513672}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.93"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.037090301513672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000214","node_attrs":{"div":103,"Nextclade_pango":{"value":"HD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"S":["T346I"],"nsp3":["T1462N"]},"labels":{"aa":"S: T346I; nsp3: T1462N","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7416800000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.73864"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.264838695526123}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"nsp5":["T93I"]},"labels":{"aa":"nsp5: T93I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.264838695526123}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":96,"Nextclade_pango":{"value":"HP.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"HP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.288678169250488}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"nsp3":["A1033V"]},"labels":{"aa":"nsp3: A1033V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.95"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.288678169250488}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000218","node_attrs":{"div":95,"Nextclade_pango":{"value":"HS.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"HS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.999259948730469}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.016602993011475}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1186099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"],"nsp2":["P129S"]},"labels":{"aa":"ORF3a: A31V, T269M; S: T284I, R403K, L513F; nsp2: P129S","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.693484306335449}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.512086391448975}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.016602993011475}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000220","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.372424125671387}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.372424125671387}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":96,"Nextclade_pango":{"value":"FZ.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}},{"name":"FZ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000222","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"HZ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"nsp6":["I124T"]},"labels":{"aa":"nsp6: I124T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000223","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"nsp5":["F223L"]},"labels":{"aa":"nsp5: F223L"}},"children":[{"name":"HZ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"HZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"nsp6":["H11Y"]},"labels":{"aa":"nsp6: H11Y"}}}]}]},{"name":"NODE_0000224","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"S":["Q146P","P631S"],"nsp3":["P1044S"],"nsp6":["T206A"]},"labels":{"aa":"S: Q146P, P631S; nsp3: P1044S; nsp6: T206A","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000225","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"nsp3":["G255V"]},"labels":{"aa":"nsp3: G255V"}},"children":[{"name":"HC.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"HC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"HC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"HC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"S":["D1084H"],"nsp3":["A534V","E1040K"]},"labels":{"aa":"S: D1084H; nsp3: A534V, E1040K","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000226","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.5769400596618652}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9873000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0346353162114479"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N417S"],"nsp1":["M85-"]},"labels":{"aa":"S: N417S; nsp1: M85-","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"EK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.174642086029053}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.5769400596618652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000227","node_attrs":{"div":99,"Nextclade_pango":{"value":"EK.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"S":["T259I"],"nsp6":["L260F"]},"labels":{"aa":"S: T259I; nsp6: L260F","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"EK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000228","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.045679092407227}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"HA.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"HA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"nsp4":["G105S"],"nsp6":["M143V"]},"labels":{"aa":"nsp4: G105S; nsp6: M143V"}}},{"name":"NODE_0000229","node_attrs":{"div":96,"Nextclade_pango":{"value":"EU.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C920T","C21910A"]}},"children":[{"name":"EU.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":98,"Nextclade_pango":{"value":"EU.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EU.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EU.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EU.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}}]}]}]},{"name":"NODE_0000231","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.344803810119629}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"GN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.837703704833984}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"GN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"nsp3":["L292I"],"nsp8":["S193F"]},"labels":{"aa":"nsp3: L292I; nsp8: S193F"}}},{"name":"GN.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"GN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"nsp8":["Q24L"]},"labels":{"aa":"nsp8: Q24L"}}},{"name":"XBB.1.5.73","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.344803810119629}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.668724536895752}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF3a":["G18V"],"nsp5":["T93I"]},"labels":{"aa":"ORF3a: G18V; nsp5: T93I"}},"children":[{"name":"GN.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000233","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.348021030426025}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.348021030426025}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"nsp14":["A119V"]},"labels":{"aa":"nsp14: A119V"}}},{"name":"GN.1.4","node_attrs":{"div":104,"Nextclade_pango":{"value":"GN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"GN.1.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"S":["L455F"],"nsp9":["P71T"]},"labels":{"aa":"S: L455F; nsp9: P71T","spike_mutations":"L455F"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.852011203765869}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.102"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.852011203765869}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":99,"Nextclade_pango":{"value":"JD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"nsp15":["H337Y"]},"labels":{"aa":"nsp15: H337Y"}},"children":[{"name":"JD.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"JD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"S":["E554K"],"nsp2":["G339S"]},"labels":{"aa":"S: E554K; nsp2: G339S","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":101,"Nextclade_pango":{"value":"JD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.622837066650391}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"JD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.622837066650391}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000237","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"JD.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF8":["A65V"],"S":["E554Q"],"nsp14":["D132E"]},"labels":{"aa":"N: P365L; ORF8: A65V; S: E554Q; nsp14: D132E","spike_mutations":"E554Q"}}},{"name":"JD.1.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":103,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.970474720001221}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"S":["A475V"],"nsp12":["A250V"]},"labels":{"aa":"S: A475V; nsp12: A250V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.970474720001221}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000239","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.197541236877441}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000240","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"nsp3":["N276K"]},"labels":{"aa":"nsp3: N276K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"KK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"S":["D1153H"],"nsp3":["D1122G"]},"labels":{"aa":"S: D1153H; nsp3: D1122G","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"KK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.20635"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2868306565498102"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000241","node_attrs":{"div":105,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.3283803462982178}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.4","node_attrs":{"div":110,"Nextclade_pango":{"value":"JD.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"JD.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1261900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3046787170970133"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF6":["N28D"],"S":["T470N"],"nsp3":["V766M"]},"labels":{"aa":"ORF6: N28D; S: T470N; nsp3: V766M","spike_mutations":"T470N"}}},{"name":"JD.1.1.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"nsp15":["R206S"]},"labels":{"aa":"nsp15: R206S"}}},{"name":"JD.1.1.5","node_attrs":{"div":110,"Nextclade_pango":{"value":"JD.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}}]}]}]}]}]},{"name":"NODE_0000242","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF8":["P38S"],"S":["L455F","F456L"],"nsp8":["A126S"]},"labels":{"aa":"ORF8: P38S; S: L455F, F456L; nsp8: A126S","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"S":["E554G"],"nsp13":["D105G"]},"labels":{"aa":"S: E554G; nsp13: D105G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.6","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.7"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.9"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.5.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000243","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"S":["E180K"],"nsp12":["T801I"]},"labels":{"aa":"S: E180K; nsp12: T801I","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"S":["N185I","A475V"],"nsp3":["N737S","I1192V"]},"labels":{"aa":"S: N185I, A475V; nsp3: N737S, I1192V","spike_mutations":"N185I, A475V"}}},{"name":"GK.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"S":["A475V"],"nsp12":["T319I"],"nsp4":["T96I"]},"labels":{"aa":"S: A475V; nsp12: T319I; nsp4: T96I","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"nsp3":["A58S"]},"labels":{"aa":"nsp3: A58S"}},"children":[{"name":"GK.3.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000247","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.4253100000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.12"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"S":["T76I","N450D"],"nsp3":["A1892T"],"nsp4":["M366I","P371S"]},"labels":{"aa":"S: T76I, N450D; nsp3: A1892T; nsp4: M366I, P371S","spike_mutations":"T76I, N450D"}}},{"name":"NODE_0000248","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.4","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.8981300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.8981300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"nsp12":["S772C"],"nsp2":["L444I"],"nsp6":["L72S"]},"labels":{"aa":"nsp12: S772C; nsp2: L444I; nsp6: L72S"}},"children":[{"name":"GK.2.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000250","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"nsp13":["D207G"],"nsp2":["R107G","E453A"]},"labels":{"aa":"nsp13: D207G; nsp2: R107G, E453A"}}},{"name":"GK.1.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"S":["S98F","K478R"],"nsp3":["A1561V"]},"labels":{"aa":"S: S98F, K478R; nsp3: A1561V","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"S":["F186L"],"nsp3":["T779I"]},"labels":{"aa":"S: F186L; nsp3: T779I","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}},{"name":"GK.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"GK.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"S":["A475V"],"nsp1":["D147G"],"nsp13":["N503K"],"nsp3":["D1774Y","V1897I"],"nsp9":["T35I"]},"labels":{"aa":"S: A475V; nsp1: D147G; nsp13: N503K; nsp3: D1774Y, V1897I; nsp9: T35I","spike_mutations":"A475V"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"S":["A475V"],"nsp2":["P129L"]},"labels":{"aa":"S: A475V; nsp2: P129L","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"S":["I68V"],"nsp14":["G265S"],"nsp3":["M1556L"]},"labels":{"aa":"S: I68V; nsp14: G265S; nsp3: M1556L","spike_mutations":"I68V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"S":["A475V"],"nsp1":["I114V"]},"labels":{"aa":"S: A475V; nsp1: I114V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":114,"Nextclade_pango":{"value":"GK.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"S":["A475V","E554K"],"nsp1":["L16F"],"nsp3":["G1389S","S1396L"]},"labels":{"aa":"S: A475V, E554K; nsp1: L16F; nsp3: G1389S, S1396L","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":114,"Nextclade_pango":{"value":"GK.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"GK.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF3a":["R134H"],"S":["K187I","A222P"],"nsp3":["P1228S"]},"labels":{"aa":"ORF3a: R134H; S: K187I, A222P; nsp3: P1228S","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000256","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF8":["A65V"],"ORF9b":["T95M"],"nsp2":["I393V"],"nsp8":["T187I"]},"labels":{"aa":"ORF8: A65V; ORF9b: T95M; nsp2: I393V; nsp8: T187I"}},"children":[{"name":"GK.1.10","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000257","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000258","node_attrs":{"div":114,"Nextclade_pango":{"value":"KN.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"KN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446400000000003"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3541583181563797"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"S":["L5F","N450D"],"nsp3":["T936I"]},"labels":{"aa":"S: L5F, N450D; nsp3: T936I","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000259","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-2.4134323596954346}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.106"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.106"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.2054524421691895}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"S":["A623V"],"nsp1":["V28I"],"nsp5":["R279H"]},"labels":{"aa":"S: A623V; nsp1: V28I; nsp5: R279H","spike_mutations":"A623V"}}},{"name":"XBB.1.5.20","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.20"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.6762609481811523}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.19","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.19"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062256813049316}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"nsp12":["R181C"]},"labels":{"aa":"nsp12: R181C"}}},{"name":"XBB.1.5.25","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.25"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.187304496765137}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.27"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.515915393829346}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"S":["K478R"],"nsp3":["E197G"]},"labels":{"aa":"S: K478R; nsp3: E197G","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.32"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.674532651901245}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"nsp4":["T60I"]},"labels":{"aa":"nsp4: T60I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.37"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.537872552871704}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.0984392166137695}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"S":["K1181I"],"nsp3":["S1428L"]},"labels":{"aa":"S: K1181I; nsp3: S1428L","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.56"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.201124668121338}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.60"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.624990940093994}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"S":["M177I"],"nsp3":["T1288I"]},"labels":{"aa":"S: M177I; nsp3: T1288I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.6"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.539541721343994}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.61"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265592575073242}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.65"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8307547569274902}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.74","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9630099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0169257119491577"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.74"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF8":["T11I"],"S":["K462R"],"nsp12":["V737I"]},"labels":{"aa":"ORF8: T11I; S: K462R; nsp12: V737I","spike_mutations":"K462R"}}},{"name":"XBB.1.5.72","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.72"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"S":["F456L"],"nsp2":["G265S"]},"labels":{"aa":"S: F456L; nsp2: G265S","spike_mutations":"F456L"}}},{"name":"XBB.1.5.76","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.76"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.102578639984131}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"nsp6":["T127A"]},"labels":{"aa":"nsp6: T127A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.78"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.389560222625732}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"nsp2":["N280D"]},"labels":{"aa":"nsp2: N280D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.81"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.81"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.628523826599121}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.449106693267822}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.83"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.83"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.545587539672852}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.84"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.84"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.249866485595703}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.89","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.89"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.89"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF7a":["T120I"],"S":["K478R","E554A"],"nsp4":["L106F"]},"labels":{"aa":"ORF7a: T120I; S: K478R, E554A; nsp4: L106F","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.88","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.88"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.88"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.301758766174316}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.9"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.153419494628906}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.91","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.91"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.91"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.224374771118164}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.90"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.90"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"S":["P621S"],"nsp15":["S261L"]},"labels":{"aa":"S: P621S; nsp15: S261L","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.94"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.94"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.96"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.96"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.111927032470703}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000260","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29580T"],"ORF10":["A8V"]},"labels":{"aa":"ORF10: A8V"}},"children":[{"name":"FD.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]},{"name":"NODE_0000261","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.786716938018799}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.786716938018799}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000262","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.83085"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000263","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"S":["P521T","V772I"],"nsp14":["V182I"]},"labels":{"aa":"S: P521T, V772I; nsp14: V182I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.83156"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9838451476656441"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.185719013214111}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.135186195373535}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.185719013214111}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.166083812713623}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"],"nsp3":["T619I"]},"labels":{"aa":"ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L; nsp3: T619I","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"KA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.103"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.166083812713623}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.184232234954834}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9350799999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"GB.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"GB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"S":["K478R"],"nsp3":["R646Q","A1818T"]},"labels":{"aa":"S: K478R; nsp3: R646Q, A1818T","spike_mutations":"K478R"}}},{"name":"XBB.1.5.46","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.184232234954834}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.094293594360352}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.094293594360352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000268","node_attrs":{"div":105,"Nextclade_pango":{"value":"HR.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF9b":["T95M"],"S":["K478R"],"nsp2":["G339S"],"nsp5":["V104I"],"nsp8":["T148I"]},"labels":{"aa":"N: I292V; ORF9b: T95M; S: K478R; nsp2: G339S; nsp5: V104I; nsp8: T148I","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"S":["K304N"],"nsp3":["A231V"],"nsp4":["D217N"]},"labels":{"aa":"S: K304N; nsp3: A231V; nsp4: D217N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.816721200942993}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"HT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.5930495262146}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"HT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.310773849487305}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.816721200942993}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000270","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000271","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF3a":["I63T"],"nsp3":["H1274Y"]},"labels":{"aa":"N: S26C; ORF3a: I63T; nsp3: H1274Y"}}}]},{"name":"NODE_0000272","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.5945"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JB.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.5945"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"nsp6":["M115T"]},"labels":{"aa":"nsp6: M115T"}},"children":[{"name":"FT.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FT.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"nsp2":["S358L"]},"labels":{"aa":"nsp2: S358L"}},"children":[{"name":"FT.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}},{"name":"FT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}}]},{"name":"internal_747c613f","node_attrs":{"div":96,"Nextclade_pango":{"value":"FT.3"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FT.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":100,"Nextclade_pango":{"value":"FT.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FT.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FT.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74638"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0924169334128189"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"internal_7eece817","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.800849199295044}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89299"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.800849199295044}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF7a":["P99L"],"ORF7b":["E3*"],"nsp3":["A655V"]},"labels":{"aa":"ORF7a: P99L; ORF7b: E3*; nsp3: A655V"}},"children":[{"name":"FD.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"S":["F456L"],"nsp9":["T34I"]},"labels":{"aa":"S: F456L; nsp9: T34I","spike_mutations":"F456L"}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"S":["Q146K"],"nsp2":["G339S"]},"labels":{"aa":"S: Q146K; nsp2: G339S","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"nsp4":["D259N"]},"labels":{"aa":"nsp4: D259N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.4"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"nsp9":["L51F"]},"labels":{"aa":"nsp9: L51F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FD.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"nsp10":["T102I"],"nsp16":["I237F"]},"labels":{"aa":"nsp10: T102I; nsp16: I237F"}}},{"name":"FD.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000281","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.78318452835083}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.25"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.561348915100098}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.26"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.213903903961182}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.213903903961182}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"nsp14":["H314N"],"nsp5":["P241L"]},"labels":{"aa":"nsp14: H314N; nsp5: P241L"}}},{"name":"NODE_0000283","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"nsp6":["L260F"]},"labels":{"aa":"nsp6: L260F"}},"children":[{"name":"HU.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"HU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF3a":["Q245R"],"S":["T76I"],"nsp1":["R24H"],"nsp13":["A505V"]},"labels":{"aa":"ORF3a: Q245R; S: T76I; nsp1: R24H; nsp13: A505V","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000284","node_attrs":{"div":98,"Nextclade_pango":{"value":"HU.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"HU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86018"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.950188045949472"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.67693"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9788766097021935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"S":["Q675K"],"nsp2":["D40E","C487Y"]},"labels":{"aa":"S: Q675K; nsp2: D40E, C487Y","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"S":["I197T"],"nsp13":["S74P"]},"labels":{"aa":"S: I197T; nsp13: S74P","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"S":["A684V"],"nsp3":["T1056I"]},"labels":{"aa":"S: A684V; nsp3: T1056I","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"nsp2":["A411V"]},"labels":{"aa":"nsp2: A411V"}},"children":[{"name":"FY.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FY.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF7b":["A15S"],"S":["S939F"],"nsp3":["T261S"]},"labels":{"aa":"ORF7b: A15S; S: S939F; nsp3: T261S","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF3a":["A103T"],"nsp4":["A380V"]},"labels":{"aa":"ORF3a: A103T; nsp4: A380V"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.8.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"S":["K478R"],"nsp14":["P158S"]},"labels":{"aa":"S: K478R; nsp14: P158S","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FY.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8926499999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"S":["P521Q"],"nsp13":["V226L"]},"labels":{"aa":"S: P521Q; nsp13: V226L","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"nsp2":["E570K"]},"labels":{"aa":"nsp2: E570K"}},"children":[{"name":"FY.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.86080265045166}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"S":["I210T"],"nsp3":["D464Y","T942I"]},"labels":{"aa":"S: I210T; nsp3: D464Y, T942I","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"nsp6":["E195G"]},"labels":{"aa":"nsp6: E195G"}}},{"name":"FY.3.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80106"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80106"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"nsp15":["V236I"],"nsp3":["Y1353F"]},"labels":{"aa":"nsp15: V236I; nsp3: Y1353F"}}},{"name":"NODE_0000294","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.4.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"nsp4":["S163F"]},"labels":{"aa":"nsp4: S163F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.5.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"S":["T572I"],"nsp3":["L865I"]},"labels":{"aa":"S: T572I; nsp3: L865I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"S":["M153I","F186S","S247N"],"nsp10":["V97I"]},"labels":{"aa":"S: M153I, F186S, S247N; nsp10: V97I","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"S":["T572I"],"nsp4":["D246N"],"nsp8":["Y135C"]},"labels":{"aa":"S: T572I; nsp4: D246N; nsp8: Y135C","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"nsp4":["M33I"]},"labels":{"aa":"nsp4: M33I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.5.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393481731414795}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"nsp14":["D258N"]},"labels":{"aa":"nsp14: D258N"}},"children":[{"name":"FY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393481731414795}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FY.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"S":["I569T"],"nsp14":["T131I"]},"labels":{"aa":"S: I569T; nsp14: T131I","spike_mutations":"I569T"}}}]},{"name":"NODE_0000301","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"S":["T572I"],"nsp12":["P227L"]},"labels":{"aa":"S: T572I; nsp12: P227L","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FY.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"S":["W64L"],"nsp3":["T779I"]},"labels":{"aa":"S: W64L; nsp3: T779I","spike_mutations":"W64L"}}},{"name":"internal_6436aedc","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000303","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-2.995669364929199}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"],"nsp14":["D222Y"],"nsp6":["L260F"]},"labels":{"aa":"ORF9b: N55S; S: E180V, K478R, S486P; nsp14: D222Y; nsp6: L260F","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-2.995669364929199}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.11"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.181058883666992}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.12"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.213220119476318}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.10","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.10"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7388600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.14"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.17"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.18"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.20"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.19","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.19"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"nsp12":["V848I"]},"labels":{"aa":"nsp12: V848I"}}},{"name":"XBB.1.16.23","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.23"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.350697994232178}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.21"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"nsp8":["V130I"]},"labels":{"aa":"nsp8: V130I"}}},{"name":"XBB.1.16.24","node_attrs":{"div":111,"Nextclade_pango":{"value":"XBB.1.16.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.24"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"S":["K182E","P521T","V551I","E554K"],"nsp2":["P568L"],"nsp3":["E154K"]},"labels":{"aa":"S: K182E, P521T, V551I, E554K; nsp2: P568L; nsp3: E154K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.22","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.22"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.469313621520996}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.28","node_attrs":{"div":107,"Nextclade_pango":{"value":"XBB.1.16.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.28"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"S":["Q613H","Q675K","V1230A"],"nsp3":["S176N"]},"labels":{"aa":"S: Q613H, Q675K, V1230A; nsp3: S176N","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.26","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.26"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.182722091674805}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.25","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.25"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"nsp2":["K330E"]},"labels":{"aa":"nsp2: K330E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":116,"Nextclade_pango":{"value":"XBB.1.16.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.27"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF3a":["M260T"],"S":["F456L","E554K"],"nsp3":["G145D","K1227R"],"nsp7":["A30T"]},"labels":{"aa":"ORF3a: M260T; S: F456L, E554K; nsp3: G145D, K1227R; nsp7: A30T","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.5","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.220455169677734}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.8"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.7","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.1.16.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.7"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"S":["T732I"],"nsp3":["Y272H"]},"labels":{"aa":"S: T732I; nsp3: Y272H","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.9"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.036108016967773}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"S":["F456L"],"nsp3":["S1682F"]},"labels":{"aa":"S: F456L; nsp3: S1682F","spike_mutations":"F456L"}}},{"name":"NODE_0000304","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64385"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF8":["F3L"],"S":["T573I"],"nsp3":["P841L"]},"labels":{"aa":"ORF8: F3L; S: T573I; nsp3: P841L","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64385"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000305","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"JM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"S":["Q52H"],"nsp2":["M418I"]},"labels":{"aa":"S: Q52H; nsp2: M418I","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000306","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.32681131362915}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":107,"Nextclade_pango":{"value":"XBB.1.16.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.29"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"S":["T883I"],"nsp14":["Y222D"],"nsp6":["L37F"]},"labels":{"aa":"S: T883I; nsp14: Y222D; nsp6: L37F","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.1.16.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.30"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.31"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"nsp2":["G339S"],"nsp3":["G283D"]},"labels":{"aa":"nsp2: G339S; nsp3: G283D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":106,"Nextclade_pango":{"value":"HF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.2","node_attrs":{"div":108,"Nextclade_pango":{"value":"HF.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.093987464904785}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"S":["A688V"],"nsp3":["P340S"]},"labels":{"aa":"S: A688V; nsp3: P340S","spike_mutations":"A688V"}}},{"name":"HF.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"HF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"HF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"S":["H1101Y"],"nsp12":["A185V"],"nsp13":["V305L"],"nsp3":["T1303I"]},"labels":{"aa":"N: A35T; S: H1101Y; nsp12: A185V; nsp13: V305L; nsp3: T1303I","spike_mutations":"H1101Y"}}}]}]},{"name":"NODE_0000309","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{}}},{"name":"internal_adf0d069","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.1121838092803955}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.3","node_attrs":{"div":112,"Nextclade_pango":{"value":"JF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"S":["Q14H","L455F","S810L"],"nsp2":["H237Y"],"nsp9":["D25G"]},"labels":{"aa":"S: Q14H, L455F, S810L; nsp2: H237Y; nsp9: D25G","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF8":["Q91H"],"S":["Q675H"],"nsp2":["E57D"]},"labels":{"aa":"ORF8: Q91H; S: Q675H; nsp2: E57D","spike_mutations":"Q675H"}}},{"name":"JF.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"JF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF8":["A15V"],"nsp2":["S32L"]},"labels":{"aa":"ORF8: A15V; nsp2: S32L"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000312","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"nsp3":["S1212L"]},"labels":{"aa":"nsp3: S1212L"}},"children":[{"name":"JF.1.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"JF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.2326700000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF10":["V30I"],"S":["A475V"],"nsp3":["P1187S"]},"labels":{"aa":"ORF10: V30I; S: A475V; nsp3: P1187S","spike_mutations":"A475V"}}},{"name":"JF.1.1.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"JF.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.14642"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"S":["K97E"],"nsp2":["R362C"]},"labels":{"aa":"S: K97E; nsp2: R362C","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"S":["E619Q"],"nsp3":["T1288N"]},"labels":{"aa":"S: E619Q; nsp3: T1288N","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.3"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000316","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000317","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FU.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"S":["N74S"],"nsp3":["A861V"]},"labels":{"aa":"S: N74S; nsp3: A861V","spike_mutations":"N74S"}}},{"name":"FU.1.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF3a":["V13L"],"nsp3":["P108H"]},"labels":{"aa":"ORF3a: V13L; nsp3: P108H"}},"children":[{"name":"GY.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"GY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8164899999999998"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.5","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"nsp3":["V947I"]},"labels":{"aa":"nsp3: V947I"}}},{"name":"GY.7","node_attrs":{"div":107,"Nextclade_pango":{"value":"GY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.7"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"nsp6":["G48C"]},"labels":{"aa":"nsp6: G48C"}}},{"name":"GY.8","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.8"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.9"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"GY.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000320","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"S":["L84I"],"nsp8":["A126S"]},"labels":{"aa":"S: L84I; nsp8: A126S","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"internal_4bba6217","node_attrs":{"div":108,"Nextclade_pango":{"value":"GY.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"GY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.2326700000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"S":["A475V"],"nsp2":["P96S"],"nsp3":["T133I","V245I"]},"labels":{"aa":"S: A475V; nsp2: P96S; nsp3: T133I, V245I","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.09637451171875}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.23"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000323","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000324","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"HL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"HL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"S":["S929N"],"nsp3":["P1132H"]},"labels":{"aa":"S: S929N; nsp3: P1132H","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.42.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.211273193359375}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"nsp3":["G1001S"]},"labels":{"aa":"nsp3: G1001S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.211273193359375}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.9.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"nsp2":["D449E"]},"labels":{"aa":"nsp2: D449E"}}},{"name":"XBB.1.9.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.9.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"S":["K478R","S486P"],"nsp3":["P200T","P1261S"]},"labels":{"aa":"S: K478R, S486P; nsp3: P200T, P1261S","spike_mutations":"K478R, S486P"}}},{"name":"XBB.1.9.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.9.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13558"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF7b":["H42Q"],"S":["R403K","A570T"],"nsp12":["T586A"],"nsp3":["A149V"]},"labels":{"aa":"ORF7b: H42Q; S: R403K, A570T; nsp12: T586A; nsp3: A149V","spike_mutations":"R403K, A570T"}}},{"name":"NODE_0000326","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"nsp14":["G44C","G481S"]},"labels":{"aa":"nsp14: G44C, G481S"}},"children":[{"name":"GD.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.331232070922852}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"GD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.068836212158203}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"GD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"S":["F59L"],"nsp8":["I185V"]},"labels":{"aa":"S: F59L; nsp8: I185V","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.9.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000327","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.3896050453186035}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.12","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.12"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.063467979431152}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"nsp3":["C1392F"]},"labels":{"aa":"nsp3: C1392F"}}},{"name":"FL.11","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF9b":["T60I"],"nsp2":["L169F"]},"labels":{"aa":"ORF9b: T60I; nsp2: L169F"}}},{"name":"FL.14","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.14"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.23352575302124}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.16"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.18","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0403361320495605}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"nsp3":["T1189I"]},"labels":{"aa":"nsp3: T1189I"}}},{"name":"FL.22","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.22"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.301856517791748}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"nsp13":["I493V"]},"labels":{"aa":"nsp13: I493V"}}},{"name":"FL.25","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.25"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.532011985778809}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.28","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.28"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF3a":["R68I"],"S":["K478R"],"nsp3":["S702F"]},"labels":{"aa":"ORF3a: R68I; S: K478R; nsp3: S702F","spike_mutations":"K478R"}}},{"name":"FL.27","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.27"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.406124591827393}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"nsp6":["V178I"]},"labels":{"aa":"nsp6: V178I"}}},{"name":"FL.29","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7904599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.29"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.6592278480529785}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"S":["S490P"],"nsp15":["I280V"]},"labels":{"aa":"S: S490P; nsp15: I280V","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.34"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.36"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"S":["R190S","K356T","T572I","A899S","A1070T"],"nsp7":["V66I"]},"labels":{"aa":"S: R190S, K356T, T572I, A899S, A1070T; nsp7: V66I","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.37"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.926265716552734}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.40"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.216498374938965}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"nsp6":["I189V"]},"labels":{"aa":"nsp6: I189V"}}},{"name":"FL.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.937436580657959}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"nsp3":["I31V"]},"labels":{"aa":"nsp3: I31V"}}},{"name":"FL.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.1645684242248535}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.511373996734619}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.411857604980469}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.3896050453186035}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000328","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C6285T","G12907A","A27507C","C28770T"],"N":["T166I"],"nsp3":["T1189I"]},"labels":{"aa":"N: T166I; nsp3: T1189I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.18.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"S":["Y200C","K478R"],"nsp12":["H650Q"],"nsp2":["G339S"]},"labels":{"aa":"S: Y200C, K478R; nsp12: H650Q; nsp2: G339S","spike_mutations":"Y200C, K478R"}}}]},{"name":"internal_d2a6176a","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.19"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"S":["F456L"],"nsp14":["A353V"]},"labels":{"aa":"S: F456L; nsp14: A353V","spike_mutations":"F456L"}}},{"name":"FL.19","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.24"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF3a":["N82S"],"S":["Q613H","A688V"],"nsp12":["I548V"]},"labels":{"aa":"ORF3a: N82S; S: Q613H, A688V; nsp12: I548V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"FL.24.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.26"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0848"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9957660361777405"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF3a":["T89I"],"S":["Q493L"],"nsp3":["E378V"]},"labels":{"aa":"ORF3a: T89I; S: Q493L; nsp3: E378V","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000332","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.30"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"S":["A484K"],"nsp1":["A79T"]},"labels":{"aa":"S: A484K; nsp1: A79T","spike_mutations":"A484K"}},"children":[{"name":"FL.30.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.30.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90046"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"FL.30","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90046"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"nsp13":["P504H"],"nsp15":["P262L"]},"labels":{"aa":"nsp13: P504H; nsp15: P262L"}}}]},{"name":"NODE_0000333","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.31"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"nsp12":["M666I"]},"labels":{"aa":"nsp12: M666I"}},"children":[{"name":"FL.31.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"],"nsp2":["A26V","C487Y"],"nsp3":["K233R"]},"labels":{"aa":"ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H; nsp2: A26V, C487Y; nsp3: K233R","spike_mutations":"D80H, K478R, Q613H"}}},{"name":"FL.31","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000334","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.32"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"S":["V6L","E554Q"],"nsp3":["V1538I"]},"labels":{"aa":"S: V6L, E554Q; nsp3: V1538I","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"S":["F456L"],"nsp15":["T114M"]},"labels":{"aa":"S: F456L; nsp15: T114M","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.33"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"nsp13":["A454V"]},"labels":{"aa":"nsp13: A454V"}},"children":[{"name":"FL.33.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.33.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.515425205230713}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.33","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_14b9e262","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.35"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.35.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917665958404541}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.39"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"nsp2":["E453K"]},"labels":{"aa":"nsp2: E453K"}},"children":[{"name":"FL.39","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"S":["K478R","P521S"],"nsp12":["T806I"],"nsp13":["P504S"]},"labels":{"aa":"S: K478R, P521S; nsp12: T806I; nsp13: P504S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000338","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9744794368743896}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9744794368743896}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000339","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.17"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"S":["N74H"],"nsp2":["L501F"],"nsp4":["G178D"]},"labels":{"aa":"S: N74H; nsp2: L501F; nsp4: G178D","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.97144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.17","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000340","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.20"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF3a":["L108F"],"S":["Q52H","F456L"],"nsp3":["I1192V"]},"labels":{"aa":"ORF3a: L108F; S: Q52H, F456L; nsp3: I1192V","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5920999999999998"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.20.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.21"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.21.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.21.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"nsp3":["V201F"],"nsp4":["I110M"]},"labels":{"aa":"nsp3: V201F; nsp4: I110M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.10"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"nsp2":["C477Y"]},"labels":{"aa":"nsp2: C477Y"}},"children":[{"name":"FL.10","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"FL.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.98073"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1216394663867173"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"],"nsp13":["N459S"],"nsp9":["G38S"]},"labels":{"aa":"N: K373N, D415E; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N; nsp13: N459S; nsp9: G38S","spike_mutations":"K356T, T523N"}}},{"name":"FL.10.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"internal_267c0772","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.23"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"nsp13":["V209I"]},"labels":{"aa":"nsp13: V209I"}},"children":[{"name":"FL.23.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"nsp3":["A1766V"]},"labels":{"aa":"nsp3: A1766V"}}},{"name":"FL.23","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000344","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"S":["Q146K","S494P"],"nsp15":["P205S"]},"labels":{"aa":"S: Q146K, S494P; nsp15: P205S","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.96117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.23.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8835"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000345","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"nsp3":["T1446I"]},"labels":{"aa":"nsp3: T1446I"}}},{"name":"FL.3.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"nsp10":["A32V"],"nsp2":["E592K"],"nsp4":["V235I"]},"labels":{"aa":"nsp10: A32V; nsp2: E592K; nsp4: V235I"}}},{"name":"FL.3.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.13"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.282327175140381}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.282327175140381}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"S":["A411S"],"nsp1":["P80S"],"nsp9":["T109I"]},"labels":{"aa":"S: A411S; nsp1: P80S; nsp9: T109I","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.13.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"S":["F456L"],"nsp3":["T182I","L1709M"]},"labels":{"aa":"S: F456L; nsp3: T182I, L1709M","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.13.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":35},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"S":["D178H"],"nsp13":["V187L"],"nsp3":["I187-","V188-","E189-","V190-","Q191-","P192-","Q193-","L194-","E195-","M196-","E197-","L198-","T199-","P200-","V201-","V202-","Q203-","T204-","I205-","E206-","V207-","N208-"],"nsp4":["T439M"]},"labels":{"aa":"S: D178H; nsp13: V187L; nsp3: I187-, V188-, E189-, V190-, Q191-, P192-, Q193-, L194-, E195-, M196-, E197-, L198-, T199-, P200-, V201-, V202-, Q203-, T204-, I205-, E206-, V207-, N208-; nsp4: T439M","spike_mutations":"D178H"}}},{"name":"FL.13.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.13.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.3.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"S":["E154Q"],"nsp3":["M84V"]},"labels":{"aa":"S: E154Q; nsp3: M84V","spike_mutations":"E154Q"}}}]},{"name":"internal_10382b90","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"S":["K182E","F456L"],"nsp3":["P841L"]},"labels":{"aa":"S: K182E, F456L; nsp3: P841L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.13.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"FL.13.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07635999999999983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"S":["Q14H","A484K"],"nsp12":["T803S"],"nsp3":["V1770L"],"nsp6":["F184V"]},"labels":{"aa":"S: Q14H, A484K; nsp12: T803S; nsp3: V1770L; nsp6: F184V","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.671235084533691}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"nsp2":["E457K"]},"labels":{"aa":"nsp2: E457K"}},"children":[{"name":"FL.38","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.38"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000351","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000352","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"nsp2":["G220V"]},"labels":{"aa":"nsp2: G220V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.15.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"internal_24b5ee08","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","C11747T","C29236T"]}}},{"name":"FL.15.4","node_attrs":{"div":103,"Nextclade_pango":{"value":"FL.15.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"nsp3":["S1367N"]},"labels":{"aa":"nsp3: S1367N"}}}]},{"name":"NODE_0000354","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G6819A","G22927T"],"S":["L455F"],"nsp3":["T1189I","S1367N"]},"labels":{"aa":"S: L455F; nsp3: T1189I, S1367N","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000355","node_attrs":{"div":110,"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"S":["A475V"],"nsp14":["G481S"],"nsp2":["A336G","Q395H"]},"labels":{"aa":"S: A475V; nsp14: G481S; nsp2: A336G, Q395H","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"FL.15.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000356","node_attrs":{"div":111,"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"KF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}},{"name":"KF.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"S":["P251H"],"nsp5":["T243I"]},"labels":{"aa":"S: P251H; nsp5: T243I","spike_mutations":"P251H"}}}]}]}]}]}]}]},{"name":"NODE_0000357","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.670197010040283}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"internal_fc124546","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"nsp13":["K460R"]},"labels":{"aa":"nsp13: K460R"}},"children":[{"name":"FL.2.3.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"FL.2.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"nsp3":["A1800T"]},"labels":{"aa":"nsp3: A1800T"}},"children":[{"name":"FL.2.7.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"S":["K478R"],"nsp6":["V149F"]},"labels":{"aa":"S: K478R; nsp6: V149F","spike_mutations":"K478R"}}},{"name":"FL.2.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000361","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"nsp13":["V169F"]},"labels":{"aa":"nsp13: V169F"}},"children":[{"name":"FL.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"S":["D1259Y"],"nsp3":["R352C"]},"labels":{"aa":"N: T334I; S: D1259Y; nsp3: R352C","spike_mutations":"D1259Y"}}},{"name":"FL.4.10","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.457831382751465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.775200128555298}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"S":["V289I"],"nsp3":["T133I"]},"labels":{"aa":"S: V289I; nsp3: T133I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"S":["K478T"],"nsp3":["T724I"]},"labels":{"aa":"S: K478T; nsp3: T724I","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.97144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0186868047371063"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3348299999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"S":["K478R"],"nsp3":["I1468T"]},"labels":{"aa":"S: K478R; nsp3: I1468T","spike_mutations":"K478R"}}}]},{"name":"NODE_0000364","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF8":["S67F"],"nsp3":["D410G"]},"labels":{"aa":"ORF8: S67F; nsp3: D410G"}}},{"name":"FL.4.6","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"S":["A701V"],"nsp3":["G175S"]},"labels":{"aa":"S: A701V; nsp3: G175S","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"nsp10":["T58I"]},"labels":{"aa":"nsp10: T58I"}}},{"name":"FL.1.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"nsp12":["M615I"],"nsp3":["T1063I"]},"labels":{"aa":"nsp12: M615I; nsp3: T1063I"}}},{"name":"FL.1.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"S":["K478R","P521T"],"nsp1":["P62S"],"nsp10":["K95R"],"nsp3":["T1482I"]},"labels":{"aa":"M: I8V; S: K478R, P521T; nsp1: P62S; nsp10: K95R; nsp3: T1482I","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"nsp16":["Q238P"]},"labels":{"aa":"nsp16: Q238P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FL.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"S":["A688S"],"nsp4":["S34F"]},"labels":{"aa":"S: A688S; nsp4: S34F","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89211"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9778643306477401"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.538186073303223}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"S":["F456L"],"nsp16":["K160R"]},"labels":{"aa":"S: F456L; nsp16: K160R","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.538186073303223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000369","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.06800999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000370","node_attrs":{"div":109,"Nextclade_pango":{"value":"KC.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"S":["S490P"],"nsp2":["S543F"],"nsp8":["T187I"]},"labels":{"aa":"S: S490P; nsp2: S543F; nsp8: T187I","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"KC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.15393000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"KC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.15393000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000371","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"S":["K478R"],"nsp15":["S147I"]},"labels":{"aa":"S: K478R; nsp15: S147I","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"nsp3":["D1115A"]},"labels":{"aa":"nsp3: D1115A"}}},{"name":"HN.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"HN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000372","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF9b":["G31E"],"nsp2":["T223I"]},"labels":{"aa":"ORF9b: G31E; nsp2: T223I"}},"children":[{"name":"HN.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":112,"Nextclade_pango":{"value":"HN.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000373","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"HN.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0007299999999998658"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3005141566416802"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}},{"name":"HN.4.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000374","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.123271942138672}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.8","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"nsp3":["E1224D"]},"labels":{"aa":"nsp3: E1224D"}}},{"name":"HN.7","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.777099132537842}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"NODE_0000375","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"nsp12":["P232S"]},"labels":{"aa":"nsp12: P232S"}},"children":[{"name":"HN.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000376","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.009539999999999936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.009539999999999936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"S":["D253G"],"nsp2":["G165C"]},"labels":{"aa":"S: D253G; nsp2: G165C","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000377","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.619708299636841}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.12"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF3a":["S40L"],"S":["Q146K","E554K"],"nsp9":["T19I"]},"labels":{"aa":"N: R195T; ORF3a: S40L; S: Q146K, E554K; nsp9: T19I","spike_mutations":"Q146K, E554K"}}},{"name":"EG.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"nsp2":["K618N"]},"labels":{"aa":"nsp2: K618N"}}},{"name":"EG.14","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.14"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF3a":["A54V"],"nsp13":["K460R"]},"labels":{"aa":"ORF3a: A54V; nsp13: K460R"}}},{"name":"EG.7","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1186099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"S":["R403K","L513F"],"nsp14":["A138V"],"nsp3":["N1713S"]},"labels":{"aa":"S: R403K, L513F; nsp14: A138V; nsp3: N1713S","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"nsp3":["S1485F"]},"labels":{"aa":"nsp3: S1485F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.619708299636841}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.9"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"S":["R403K"],"nsp13":["N46S"],"nsp3":["T656I"]},"labels":{"aa":"S: R403K; nsp13: N46S; nsp3: T656I","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.20938"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17686"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.10"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17686"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000380","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"S":["S494P","A701V"],"nsp1":["R24C"]},"labels":{"aa":"S: S494P, A701V; nsp1: R24C","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1256300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.10.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1256300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0006818771362305}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"nsp14":["P46S"],"nsp3":["V1885L"],"nsp6":["V114I"]},"labels":{"aa":"nsp14: P46S; nsp3: V1885L; nsp6: V114I"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.6"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000382","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.6.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}},{"name":"EG.6.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.6.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07635999999999983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"S":["L242I","A484K"],"nsp14":["R52K"],"nsp3":["P968L"]},"labels":{"aa":"S: L242I, A484K; nsp14: R52K; nsp3: P968L","spike_mutations":"L242I, A484K"}}}]}]},{"name":"NODE_0000383","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"S":["K304N"],"nsp2":["A522V"]},"labels":{"aa":"N: R204P; S: K304N; nsp2: A522V","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"S":["I742V"],"nsp13":["I370V"],"nsp2":["K142R"]},"labels":{"aa":"S: I742V; nsp13: I370V; nsp2: K142R","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"S":["K356T"],"nsp3":["G1447D"]},"labels":{"aa":"S: K356T; nsp3: G1447D","spike_mutations":"K356T"}}},{"name":"EG.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF3a":["H243R"],"S":["V327I","F456L"],"nsp14":["R98I"],"nsp3":["Y816H"]},"labels":{"aa":"ORF3a: H243R; S: V327I, F456L; nsp14: R98I; nsp3: Y816H","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"nsp12":["H882Y"],"nsp3":["Y647C"]},"labels":{"aa":"nsp12: H882Y; nsp3: Y647C"}}},{"name":"EG.4.5","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"nsp4":["L15F"]},"labels":{"aa":"nsp4: L15F"}}},{"name":"NODE_0000386","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"S":["V70F","I312V"],"nsp2":["T223I"]},"labels":{"aa":"S: V70F, I312V; nsp2: T223I","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"S":["S640F"],"nsp12":["D170G"],"nsp15":["P270L"]},"labels":{"aa":"S: S640F; nsp12: D170G; nsp15: P270L","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"nsp3":["S1682F"]},"labels":{"aa":"nsp3: S1682F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF3a":["F114V","D199E"],"S":["P217L"],"nsp12":["N874K"],"nsp3":["P1103L","A1461T"]},"labels":{"aa":"ORF3a: F114V, D199E; S: P217L; nsp12: N874K; nsp3: P1103L, A1461T","spike_mutations":"P217L"}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.697697162628174}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF10":["S23F"],"S":["F456L"],"nsp2":["A510V"],"nsp4":["A380V"]},"labels":{"aa":"ORF10: S23F; S: F456L; nsp2: A510V; nsp4: A380V","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000389","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"nsp12":["T248I"]},"labels":{"aa":"nsp12: T248I"}}},{"name":"NODE_0000390","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF3a":["I118V"],"nsp3":["H295Y","N1337S"]},"labels":{"aa":"ORF3a: I118V; nsp3: H295Y, N1337S"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.5.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"EG.5.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000391","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.3748607635498047}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.3748607635498047}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.13","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.12","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.10","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.850919246673584}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"nsp6":["I189V"]},"labels":{"aa":"nsp6: I189V"}}},{"name":"EG.5.1.15","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.343207836151123}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"nsp2":["T573I"]},"labels":{"aa":"nsp2: T573I"}}},{"name":"EG.5.1.17","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.16","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"nsp16":["A34V"]},"labels":{"aa":"nsp16: A34V"}}},{"name":"EG.5.1.14","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"nsp14":["V120I"]},"labels":{"aa":"nsp14: V120I"}}},{"name":"EG.5.1.19","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.18","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF3a":["S220I"],"nsp4":["G239S"]},"labels":{"aa":"ORF3a: S220I; nsp4: G239S"}}},{"name":"EG.5.1.7","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.3128533363342285}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.5","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.5.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"nsp13":["T351I"],"nsp15":["L298V"],"nsp5":["L30I"]},"labels":{"aa":"nsp13: T351I; nsp15: L298V; nsp5: L30I"}}},{"name":"EG.5.1.9","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"S":["L176F"],"nsp3":["D164G"]},"labels":{"aa":"S: L176F; nsp3: D164G","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.377831935882568}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":106,"Nextclade_pango":{"value":"JR.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"JR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000395","node_attrs":{"div":111,"Nextclade_pango":{"value":"JR.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"S":["L455F","K478R"],"nsp16":["G113C"],"nsp2":["L270F"]},"labels":{"aa":"S: L455F, K478R; nsp16: G113C; nsp2: L270F","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"JR.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.73257"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4312755323086508"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"S":["K356Q"],"nsp4":["A298V"]},"labels":{"aa":"S: K356Q; nsp4: A298V","spike_mutations":"K356Q"}}},{"name":"JR.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"JR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000396","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"KB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"internal_b60a1521","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"NODE_0000398","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"nsp2":["R362C"]},"labels":{"aa":"nsp2: R362C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000399","node_attrs":{"div":109,"Nextclade_pango":{"value":"JG.3"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"S":["L455F","S704L"],"nsp3":["T1456I"]},"labels":{"aa":"S: L455F, S704L; nsp3: T1456I","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"JG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"JG.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF3a":["L140F"],"S":["T307I"],"nsp3":["S1738L"]},"labels":{"aa":"ORF3a: L140F; S: T307I; nsp3: S1738L","spike_mutations":"T307I"}}},{"name":"JG.3.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"JG.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.4253100000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.8458521366119385}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.3","node_attrs":{"div":111,"Nextclade_pango":{"value":"JG.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3.4","node_attrs":{"div":112,"Nextclade_pango":{"value":"JG.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.12369441986084}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000400","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.735776662826538}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"S":["F157L"],"nsp3":["S1039L"]},"labels":{"aa":"S: F157L; nsp3: S1039L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.735776662826538}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"HV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000401","node_attrs":{"div":109,"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.068493127822876}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1.10","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.025979999999999802"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.068493127822876}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"HV.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21974"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3005451981781486"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.11","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0887599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3341105633249508"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.31048583984375}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.5","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.4","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.7","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"HV.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.8","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"S":["T208M"],"nsp2":["T166I"]},"labels":{"aa":"S: T208M; nsp2: T166I","spike_mutations":"T208M"}}},{"name":"internal_2378868c","node_attrs":{"div":110,"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}},"children":[{"name":"HV.1.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.38161000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3552393372267753"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}},{"name":"HV.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.048559999999999943"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000403","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"nsp3":["T976I","P1200S"]},"labels":{"aa":"nsp3: T976I, P1200S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000404","node_attrs":{"div":114,"Nextclade_pango":{"value":"HV.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"HV.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000405","node_attrs":{"div":115,"Nextclade_pango":{"value":"KL.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"KL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.008039999999999839"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"KL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.008039999999999839"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF3a":["S40P"],"S":["H1101Y"],"nsp14":["Q354H"]},"labels":{"aa":"ORF3a: S40P; S: H1101Y; nsp14: Q354H","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000406","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"nsp12":["D63N"]},"labels":{"aa":"nsp12: D63N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13706999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1972306507819483"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.19","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.508697986602783}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.21","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.1481699999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.205901853206978"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.49366"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.310148541751831"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF3a":["M5I"],"S":["L452Q","L455F"],"nsp14":["R98K"]},"labels":{"aa":"ORF3a: M5I; S: L452Q, L455F; nsp14: R98K","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":125,"Nextclade_pango":{"value":"HK.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"],"nsp2":["P129L"],"nsp3":["H323Y","E1294D"],"nsp6":["V182F"]},"labels":{"aa":"N: P365L; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R; nsp2: P129L; nsp3: H323Y, E1294D; nsp6: V182F","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"nsp3":["G1691D"]},"labels":{"aa":"nsp3: G1691D"}}},{"name":"HK.31","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"nsp2":["G424S"]},"labels":{"aa":"nsp2: G424S"}}},{"name":"HK.32","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.30","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"S":["T307I","L455F"],"nsp3":["V1201I"]},"labels":{"aa":"S: T307I, L455F; nsp3: V1201I","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.11"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}},{"name":"HK.11.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.2"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.20"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"S":["L455F"],"nsp3":["P1326S"]},"labels":{"aa":"S: L455F; nsp3: P1326S","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.6088199999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2183176254438959"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.24"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.23"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000413","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"S":["L455F"],"nsp4":["T143N"]},"labels":{"aa":"S: L455F; nsp4: T143N","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"HK.23.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.48614000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3534097328298118"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"S":["A348S"],"nsp15":["G146D"],"nsp2":["G88W","E162G","D286N"]},"labels":{"aa":"S: A348S; nsp15: G146D; nsp2: G88W, E162G, D286N","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"S":["D253G"],"nsp3":["A1105T"]},"labels":{"aa":"S: D253G; nsp3: A1105T","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.26"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.919094562530518}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.27"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"nsp3":["T771I"]},"labels":{"aa":"nsp3: T771I"}},"children":[{"name":"HK.27","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000417","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.27.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.27.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.34"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"S":["F186S"],"nsp6":["V91M"]},"labels":{"aa":"S: F186S; nsp6: V91M","spike_mutations":"F186S"}},"children":[{"name":"HK.34.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.34","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.13"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.202107906341553}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000421","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"HK.13.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"S":["T250I"],"nsp10":["A104V"],"nsp13":["T255A"]},"labels":{"aa":"N: T379I; S: T250I; nsp10: A104V; nsp13: T255A","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.15","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"S":["A262T"],"nsp3":["Q173R"]},"labels":{"aa":"S: A262T; nsp3: Q173R","spike_mutations":"A262T"}}},{"name":"HK.16","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.089319229125977}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.3"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.12","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.10","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.13","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.741406440734863}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"S":["A475V"],"nsp15":["I327T"]},"labels":{"aa":"S: A475V; nsp15: I327T","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.4","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"S":["P809S"],"nsp2":["T160I"]},"labels":{"aa":"S: P809S; nsp2: T160I","spike_mutations":"P809S"}}},{"name":"HK.3.5","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"S":["P174S"],"nsp3":["E392K"]},"labels":{"aa":"S: P174S; nsp3: E392K","spike_mutations":"P174S"}}},{"name":"HK.3.7","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.6","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.8","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"S":["E554K"],"nsp12":["T252N"]},"labels":{"aa":"S: E554K; nsp12: T252N","spike_mutations":"E554K"}}},{"name":"NODE_0000425","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.2"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF8":["A55T"],"S":["Q677H"],"nsp1":["E148A"],"nsp15":["T325I"],"nsp2":["T434I"]},"labels":{"aa":"ORF8: A55T; S: Q677H; nsp1: E148A; nsp15: T325I; nsp2: T434I","spike_mutations":"Q677H"}}},{"name":"HK.3.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.2","node_attrs":{"div":118,"Nextclade_pango":{"value":"HK.3.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"],"nsp3":["G1524E"]},"labels":{"aa":"ORF3a: I35T; ORF8: M1L; S: N185D; nsp3: G1524E","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000426","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.3","node_attrs":{"div":2,"Nextclade_pango":{"value":"B.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.3"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.030364513397217}},"branch_attrs":{"mutations":{"nuc":["G1440A","G2891A"],"nsp2":["G212D"],"nsp3":["A58T"]},"labels":{"aa":"nsp2: G212D; nsp3: A58T"}}},{"name":"B.23","node_attrs":{"div":2,"Nextclade_pango":{"value":"B.23"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.23"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.471245765686035}},"branch_attrs":{"mutations":{"nuc":["A1605-","T1606-","G1607-","C20270T","C29870A"],"nsp15":["A217V"],"nsp2":["D268-"]},"labels":{"aa":"nsp15: A217V; nsp2: D268-"}}},{"name":"B.55","node_attrs":{"div":1,"Nextclade_pango":{"value":"B.55"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.55"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.3334856033325195}},"branch_attrs":{"mutations":{"nuc":["T514C"]}}},{"name":"NODE_0000427","node_attrs":{"div":1,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.376059532165527}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"B.4","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.4"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.114971160888672}},"branch_attrs":{"mutations":{"nuc":["G1397A","T28688C","G29742T"],"nsp2":["V198I"]},"labels":{"aa":"nsp2: V198I"}}},{"name":"NODE_0000428","node_attrs":{"div":3,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.5978965759277344}},"branch_attrs":{"mutations":{"nuc":["C14805T","G26144T"],"ORF3a":["G251V"]},"labels":{"aa":"ORF3a: G251V"}},"children":[{"name":"B.39","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.39"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.39"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["A1515G","C9223T","T17247C"],"nsp2":["H237R"]},"labels":{"aa":"nsp2: H237R"}}},{"name":"B.40","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.40"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.40"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.6938891410827637}},"branch_attrs":{"mutations":{"nuc":["A2480G","C2558T"],"nsp2":["I559V","P585S"]},"labels":{"aa":"nsp2: I559V, P585S"}}}]},{"name":"NODE_0000429","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.6"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{"nuc":["C6312A","C13730T","C23929T","C28311T"],"N":["P13L"],"ORF9b":["P10S"],"nsp12":["A97V"],"nsp3":["T1198K"]},"labels":{"aa":"N: P13L; ORF9b: P10S; nsp12: A97V; nsp3: T1198K"}},"children":[{"name":"B.6","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.6"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{}}},{"name":"B.6.6","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.6.6"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.402256011962891}},"branch_attrs":{"mutations":{"nuc":["C6310A","C19524T"],"nsp3":["S1197R"]},"labels":{"aa":"nsp3: S1197R"}}}]}]},{"name":"NODE_0000430","node_attrs":{"div":3,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.371846675872803}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S","clade":"19B"}},"children":[{"name":"A.1","node_attrs":{"div":6,"Nextclade_pango":{"value":"A.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-3.6224653720855713}},"branch_attrs":{"mutations":{"nuc":["C17747T","A17858G","C18060T"],"nsp13":["P504L","Y541C"]},"labels":{"aa":"nsp13: P504L, Y541C"}}},{"name":"A","node_attrs":{"div":3,"Nextclade_pango":{"value":"A"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.371846675872803}},"branch_attrs":{"mutations":{}}},{"name":"A.5","node_attrs":{"div":4,"Nextclade_pango":{"value":"A.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.451474189758301}},"branch_attrs":{"mutations":{"nuc":["C26088T"]}}},{"name":"A.3","node_attrs":{"div":13,"Nextclade_pango":{"value":"A.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.3"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.0400519371032715}},"branch_attrs":{"mutations":{"nuc":["T490A","C3177T","C6040T","G12478A","T18736C","C24034T","T26729C","G28077C","C28896G","A29700G"],"N":["A208G"],"ORF8":["V62L"],"nsp1":["D75E"],"nsp14":["F233L"],"nsp3":["P153L"],"nsp8":["M129I"]},"labels":{"aa":"N: A208G; ORF8: V62L; nsp1: D75E; nsp14: F233L; nsp3: P153L; nsp8: M129I"}}},{"name":"NODE_0000431","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.2"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["T9477A","C14805T","G25979T","C28657T","C28863T"],"N":["S197L"],"ORF3a":["G196V"],"nsp4":["F308Y"]},"labels":{"aa":"N: S197L; ORF3a: G196V; nsp4: F308Y"}},"children":[{"name":"A.2","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000432","node_attrs":{"div":27,"Nextclade_pango":{"value":"A.2.5"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{"nuc":["C275T","C1567T","C4543T","A5234G","A5488G","C10029T","C11005A","C12815T","C16466T","T16857C","T18417C","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T22917G","A23403G","G24697A","C25613T","C26681T","A28272T","G28975T","C29421T"],"N":["M234I","P383L"],"ORF3a":["S74F"],"S":["L141-","G142-","V143-","L452R","D614G"],"nsp1":["L4F"],"nsp13":["P77L"],"nsp3":["K839E"],"nsp4":["T492I"],"nsp6":["H11Q"]},"labels":{"aa":"N: M234I, P383L; ORF3a: S74F; S: L141-, G142-, V143-, L452R, D614G; nsp1: L4F; nsp13: P77L; nsp3: K839E; nsp4: T492I; nsp6: H11Q","spike_mutations":"L141-, G142-, V143-, L452R, D614G"}},"children":[{"name":"A.2.5","node_attrs":{"div":27,"Nextclade_pango":{"value":"A.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{}}},{"name":"A.2.5.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"A.2.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.212984561920166}},"branch_attrs":{"mutations":{"nuc":["T15326C","A22525G","G27706T"],"ORF7a":["A105S"],"nsp12":["M629T"]},"labels":{"aa":"ORF7a: A105S; nsp12: M629T"}}},{"name":"A.2.5.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"A.2.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.277773380279541}},"branch_attrs":{"mutations":{"nuc":["C1722T","C29366T"],"N":["P365S"],"nsp2":["A306V"]},"labels":{"aa":"N: P365S; nsp2: A306V"}}},{"name":"A.2.5.3","node_attrs":{"div":30,"Nextclade_pango":{"value":"A.2.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.3"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["G2272A","G22992A","C29870A"],"S":["S477N"]},"labels":{"aa":"S: S477N","spike_mutations":"S477N"}}}]}]},{"name":"internal_446d","node_attrs":{"div":5,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.395915508270264}},"branch_attrs":{"mutations":{"nuc":["G28878A","G29742A"],"N":["S202N"]},"labels":{"aa":"N: S202N"}},"children":[{"name":"A.18","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.18"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.22163200378418}},"branch_attrs":{"mutations":{"nuc":["A3234T","C15126T","A23403G","C27812T"],"S":["D614G"],"nsp3":["Q172L"]},"labels":{"aa":"S: D614G; nsp3: Q172L","spike_mutations":"D614G"}}},{"name":"A.21","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.21"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.21"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C10138T","G11417T","G23402A","G25687T"],"ORF3a":["A99S"],"S":["D614N"],"nsp6":["V149F"]},"labels":{"aa":"ORF3a: A99S; S: D614N; nsp6: V149F","spike_mutations":"D614N"}}},{"name":"NODE_0000434","node_attrs":{"div":6,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22468T"]}},"children":[{"name":"A.28","node_attrs":{"div":20,"Nextclade_pango":{"value":"A.28"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.28"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A481G","G521T","C2197T","G10850A","C12469T","C16391T","G17014T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A23064C","C23525T","C25904T","C27294T","A27489G","A28272T","C28377T"],"N":["A35V"],"ORF3a":["S171L"],"ORF9b":["R32C"],"S":["H69-","V70-","N501T","H655Y"],"nsp1":["V86F"],"nsp13":["A52V","D260Y"],"nsp5":["A266T"]},"labels":{"aa":"N: A35V; ORF3a: S171L; ORF9b: R32C; S: H69-, V70-, N501T, H655Y; nsp1: V86F; nsp13: A52V, D260Y; nsp5: A266T","spike_mutations":"H69-, V70-, N501T, H655Y"}}},{"name":"NODE_0000435","node_attrs":{"div":7,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A361G"]}},"children":[{"name":"A.19","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.19"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.19"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12820G","A23403G"],"S":["D614G"]},"labels":{"aa":"S: D614G","spike_mutations":"D614G"}}},{"name":"A.27","node_attrs":{"div":24,"Nextclade_pango":{"value":"A.27"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.27"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C1122T","C2509T","A9204G","A11217G","C16466T","A18366G","A20262G","C21614T","T22917G","A23063T","C23520T","C23525T","G23948T","G25218T","T25541C","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","C27247T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28273T"],"ORF3a":["V50A","N257-","P258-"],"ORF8":["D119-","F120-"],"S":["L18F","L452R","N501Y","A653V","H655Y","D796Y","G1219V"],"nsp13":["P77L"],"nsp2":["P106L"],"nsp4":["D217G"],"nsp6":["N82S"]},"labels":{"aa":"ORF3a: V50A, N257-, P258-; ORF8: D119-, F120-; S: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V; nsp13: P77L; nsp2: P106L; nsp4: D217G; nsp6: N82S","spike_mutations":"L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V"}}}]}]},{"name":"NODE_0000436","node_attrs":{"div":7,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.347469329833984}},"branch_attrs":{"mutations":{"nuc":["G11230T","G28167A"],"ORF8":["E92K"],"nsp6":["M86I"]},"labels":{"aa":"ORF8: E92K; nsp6: M86I"}},"children":[{"name":"A.25","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.25"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.25"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5544T"],"nsp3":["T942I"]},"labels":{"aa":"nsp3: T942I"}}},{"name":"A.29","node_attrs":{"div":24,"Nextclade_pango":{"value":"A.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"S:142-143"},"designation_date":{"value":"2021-05-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.29"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G521T","C2110T","C8605T","C9891T","C12970T","G17964T","A19426G","A21069G","G21255T","T21982-","T21983-","T21984-","G21985-","T21992-","A21993-","A22194-","T22195-","T22196-","T22907C","A23063T","T23255C","C23525T","T26767G","G27604T","A28271-","G28337T","C29739T"],"M":["I82S"],"N":["D22Y"],"ORF7a":["V71L"],"ORF9b":["Q18H"],"S":["F140-","L141-","Y144-","N211-","L212I","Y449H","N501Y","F565L","H655Y"],"nsp1":["V86F"],"nsp13":["M576I"],"nsp14":["I463V"],"nsp4":["A446V"]},"labels":{"aa":"M: I82S; N: D22Y; ORF7a: V71L; ORF9b: Q18H; S: F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y; nsp1: V86F; nsp13: M576I; nsp14: I463V; nsp4: A446V","spike_mutations":"F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y"}}},{"name":"NODE_0000437","node_attrs":{"div":18,"Nextclade_pango":{"value":"A.23"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C4573T","C10747T","G11266T","C16575T","C17745T","C22000T","C22033A","G22661T","G23401T","T24097C","G28378C"],"ORF9b":["R32P"],"S":["F157L","V367F","Q613H"],"nsp6":["L98F"]},"labels":{"aa":"ORF9b: R32P; S: F157L, V367F, Q613H; nsp6: L98F","spike_mutations":"F157L, V367F, Q613H"}},"children":[{"name":"A.23.1","node_attrs":{"div":20,"Nextclade_pango":{"value":"A.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["G11521T","C23604G"],"S":["P681R"],"nsp6":["M183I"]},"labels":{"aa":"S: P681R; nsp6: M183I","spike_mutations":"P681R"}}},{"name":"A.23","node_attrs":{"div":18,"Nextclade_pango":{"value":"A.23"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000438","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C14408T","A23403G"],"S":["D614G"],"nsp12":["P323L"]},"labels":{"aa":"S: D614G; nsp12: P323L","clade":"20A","spike_mutations":"D614G"}},"children":[{"name":"B.1","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{}}},{"name":"B.1.128","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.128"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.128"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9753756523132324}},"branch_attrs":{"mutations":{"nuc":["C8293T","T18488C","T24739C","A26530G"],"M":["D3G"],"nsp14":["I150T"]},"labels":{"aa":"M: D3G; nsp14: I150T"}}},{"name":"B.1.143","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.143"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.143"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.877503871917725}},"branch_attrs":{"mutations":{"nuc":["C4084T"]}}},{"name":"B.1.126","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.126"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.126"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.10439395904541}},"branch_attrs":{"mutations":{"nuc":["T3011C","G22205T","T27869C","T28853G"],"N":["S194A"],"S":["D215Y"]},"labels":{"aa":"N: S194A; S: D215Y","spike_mutations":"D215Y"}}},{"name":"B.1.179","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.179"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.179"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.580779075622559}},"branch_attrs":{"mutations":{"nuc":["C7834T"]}}},{"name":"B.1.195","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.195"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.195"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.6570916175842285}},"branch_attrs":{"mutations":{"nuc":["A1T","A6466G"]}}},{"name":"B.1.206","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.206"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.206"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.032977104187012}},"branch_attrs":{"mutations":{"nuc":["G2282A","T9742C","C17639T"],"nsp13":["S468L"],"nsp2":["E493K"]},"labels":{"aa":"nsp13: S468L; nsp2: E493K"}}},{"name":"B.1.22","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.22"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.218311786651611}},"branch_attrs":{"mutations":{"nuc":["C1594T","C11109T","G25563T"],"ORF3a":["Q57H"],"nsp6":["A46V"]},"labels":{"aa":"ORF3a: Q57H; nsp6: A46V"}}},{"name":"B.1.222","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.222"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.222"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.235558032989502}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.247","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1.247"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.247"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{}}},{"name":"B.1.260","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.260"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.260"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.373620986938477}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}}},{"name":"B.1.379","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.379"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.379"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.878320217132568}},"branch_attrs":{"mutations":{"nuc":["A11782G"]}}},{"name":"B.1.377","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.377"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.377"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.68954610824585}},"branch_attrs":{"mutations":{"nuc":["G28300T","G28883A","A28998G"],"N":["Q9H","G204R","Q242R"],"ORF9b":["S6I"]},"labels":{"aa":"N: Q9H, G204R, Q242R; ORF9b: S6I"}}},{"name":"B.1.380","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.380"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.380"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.045155048370361}},"branch_attrs":{"mutations":{"nuc":["C7420T","C12439T","T26017G"],"ORF3a":["S209A"]},"labels":{"aa":"ORF3a: S209A"}}},{"name":"B.1.391","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.391"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.391"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.035617351531982}},"branch_attrs":{"mutations":{"nuc":["C16289T","G25429T"],"ORF3a":["V13L"],"nsp13":["A18V"]},"labels":{"aa":"ORF3a: V13L; nsp13: A18V"}}},{"name":"B.1.393","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.393"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.393"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.217160701751709}},"branch_attrs":{"mutations":{"nuc":["A5040G","G29477T","C29774T"],"N":["D402Y"],"nsp3":["Q774R"]},"labels":{"aa":"N: D402Y; nsp3: Q774R"}}},{"name":"B.1.395","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.395"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.395"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.251682281494141}},"branch_attrs":{"mutations":{"nuc":["C6990T"],"nsp3":["S1424F"]},"labels":{"aa":"nsp3: S1424F"}}},{"name":"B.1.411","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.411"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.411"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.553277492523193}},"branch_attrs":{"mutations":{"nuc":["C1519T","A14774G","G15438T","T16062C","G17334T","C25037T","C27945T"],"ORF8":["Q18*"],"S":["H1159Y"],"nsp12":["D445G","M666I"]},"labels":{"aa":"ORF8: Q18*; S: H1159Y; nsp12: D445G, M666I","spike_mutations":"H1159Y"}}},{"name":"B.1.524","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.524"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.524"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C6312T","C8637T","A10124G","C17518T","C21516T","C21622A","C23664T","A28133T","C28854T"],"N":["S194L"],"S":["A701V"],"nsp13":["L428F"],"nsp3":["T1198I"],"nsp4":["T28I"],"nsp5":["T24A"]},"labels":{"aa":"N: S194L; S: A701V; nsp13: L428F; nsp3: T1198I; nsp4: T28I; nsp5: T24A","spike_mutations":"A701V"}}},{"name":"B.1.525","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.525"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Eta"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21D (Eta)"},"partiallyAliased":{"value":"B.1.525"},"clade_nextstrain":{"value":"21D"},"clade_membership":{"value":"21D"},"placement_prior":{"value":-3.2125132083892822}},"branch_attrs":{"mutations":{"nuc":["C1498T","A1807G","G2659A","C6285T","T8593C","C9565T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14407T","C18171T","A20724G","A21717G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G23012A","G23593C","T24224C","C24748T","T26767C","T27205-","T27206-","T27207-","C28278-","T28279-","G28280-","C28308G","A28699G","C28887T","G29543T"],"M":["I82T"],"N":["S2-","D3Y","A12G","T205I"],"ORF6":["F2-"],"ORF9b":["H9D"],"S":["Q52R","A67V","H69-","V70-","Y144-","E484K","Q677H","F888L"],"nsp12":["L323F"],"nsp3":["T1189I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; N: S2-, D3Y, A12G, T205I; ORF6: F2-; ORF9b: H9D; S: Q52R, A67V, H69-, V70-, Y144-, E484K, Q677H, F888L; nsp12: L323F; nsp3: T1189I; nsp6: S106-, G107-, F108-","clade":"Eta","spike_mutations":"Q52R, A67V, H69-, V70-, Y144-, E484K, Q677H, F888L"}}},{"name":"B.1.537","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.537"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.537"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.682881832122803}},"branch_attrs":{"mutations":{"nuc":["G4354A","C6573T","C25528T"],"ORF3a":["L46F"],"nsp3":["S1285F"]},"labels":{"aa":"ORF3a: L46F; nsp3: S1285F"}}},{"name":"B.1.527","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.527"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.527"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.690547943115234}},"branch_attrs":{"mutations":{"nuc":["A1G","C6354T"],"nsp3":["S1212L"]},"labels":{"aa":"nsp3: S1212L"}}},{"name":"B.1.544","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.544"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.544"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.710533142089844}},"branch_attrs":{"mutations":{"nuc":["G13348T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"B.1.540","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.540"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.540"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.101134300231934}},"branch_attrs":{"mutations":{"nuc":["G28221T"],"ORF8":["E110*"]},"labels":{"aa":"ORF8: E110*"}}},{"name":"B.1.549","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.549"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.549"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.000479221343994}},"branch_attrs":{"mutations":{"nuc":["C1514T","G5542T","C10029T","A11451G","G17122T","G17320T","C18463T","G23611A"],"nsp13":["A296S","A362S"],"nsp14":["P142S"],"nsp2":["H237Y"],"nsp3":["Q941H"],"nsp4":["T492I"],"nsp6":["Q160R"]},"labels":{"aa":"nsp13: A296S, A362S; nsp14: P142S; nsp2: H237Y; nsp3: Q941H; nsp4: T492I; nsp6: Q160R"}}},{"name":"B.1.538","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.538"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.538"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.967286109924316}},"branch_attrs":{"mutations":{"nuc":["C313T","C5700A","C29870A"],"nsp3":["A994D"]},"labels":{"aa":"nsp3: A994D"}}},{"name":"B.1.560","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.560"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.560"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.9053778648376465}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}}},{"name":"B.1.618","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.618"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.618"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G105T","C853T","C1684T","A3830G","C4809T","T5263C","G14245A","A17066G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","G23012A","T25084C","C25844T","C26885T","G26909T","C27493T","G27852T","A27979T","G28325A","G28628T","G28922T","G28975T","G29372C"],"N":["G18S","A119S","A217S","M234I","E367Q"],"ORF3a":["T151I"],"ORF7a":["P34S"],"ORF7b":["E33*"],"ORF8":["Q29L"],"S":["Y145-","H146-","E484K"],"nsp12":["D269N"],"nsp13":["Y277C"],"nsp3":["S371G","S697F"]},"labels":{"aa":"N: G18S, A119S, A217S, M234I, E367Q; ORF3a: T151I; ORF7a: P34S; ORF7b: E33*; ORF8: Q29L; S: Y145-, H146-, E484K; nsp12: D269N; nsp13: Y277C; nsp3: S371G, S697F","spike_mutations":"Y145-, H146-, E484K"}}},{"name":"B.1.639","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.639"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.639"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.999648571014404}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22020C","C22995A","G23012A","C24138A","G24368T","A26161-","T27919C","A28271G","A28742G"],"N":["I157V"],"ORF3a":["N257-"],"ORF8":["I9T"],"S":["H69-","V70-","M153T","T478K","E484K","T859N","D936Y"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: I157V; ORF3a: N257-; ORF8: I9T; S: H69-, V70-, M153T, T478K, E484K, T859N, D936Y; nsp6: S106-, G107-, F108-","spike_mutations":"H69-, V70-, M153T, T478K, E484K, T859N, D936Y"}}},{"name":"B.1.8","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.8"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.388725757598877}},"branch_attrs":{"mutations":{"nuc":["A24862G"]}}},{"name":"B.1.78","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.78"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.78"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.461181163787842}},"branch_attrs":{"mutations":{"nuc":["G29422T"]}}},{"name":"B.1.91","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.91"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.91"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.197771072387695}},"branch_attrs":{"mutations":{"nuc":["G24077T"],"S":["D839Y"]},"labels":{"aa":"S: D839Y","spike_mutations":"D839Y"}}},{"name":"NODE_0000439","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.110"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.563884258270264}},"branch_attrs":{"mutations":{"nuc":["C8389T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.110","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.110"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.563884258270264}},"branch_attrs":{"mutations":{}}},{"name":"B.1.110.3","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.110.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.013157367706299}},"branch_attrs":{"mutations":{"nuc":["C601T","G27915A"],"ORF8":["G8R"]},"labels":{"aa":"ORF8: G8R"}}}]},{"name":"NODE_0000440","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.797828674316406}},"branch_attrs":{"mutations":{"nuc":["G3871T"],"nsp3":["K384N"]},"labels":{"aa":"nsp3: K384N"}},"children":[{"name":"B.1.378","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.378"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.378"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.797828674316406}},"branch_attrs":{"mutations":{"nuc":["A6-","G7-","G8-","T9-","T13-","A14-","C15-","C16-","T17-","T18-","C19-","C20-","C21-","A22-","G23-","G24-"]}}},{"name":"NODE_0000441","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.391294956207275}},"branch_attrs":{"mutations":{"nuc":["A696C","T3931C","C28977T"],"N":["S235F"],"nsp1":["D144A"]},"labels":{"aa":"N: S235F; nsp1: D144A"}},"children":[{"name":"B.1.139","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.139"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.139"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.391294956207275}},"branch_attrs":{"mutations":{}}},{"name":"B.1.565","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.565"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8670549392700195}},"branch_attrs":{"mutations":{"nuc":["C6285T","C19524T","C20429T"],"nsp15":["P270L"],"nsp3":["T1189I"]},"labels":{"aa":"nsp15: P270L; nsp3: T1189I"}}}]}]},{"name":"NODE_0000442","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.837924003601074}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","C23625T","A26161-"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"B.1.634","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.634"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G613A","C841T","A7142G","T8634C","A9614G","C9693T","A9754C","C11289-","G11291-","G11292-","G15451A","C16466T","C20823T","T21615G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A22036C","G23012A","C23854A","C26681T","T27645C","C27735T","A28271T","C28531T","C28606T","A28910T"],"N":["N213Y"],"ORF3a":["N257-"],"ORF9b":["T83I"],"S":["L18R","H69-","V70-","T95I","R158S","E484K","N764K"],"nsp12":["G671S"],"nsp13":["P77L"],"nsp3":["S1475G"],"nsp4":["I27T","T354A","A380V","R400S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: N213Y; ORF3a: N257-; ORF9b: T83I; S: L18R, H69-, V70-, T95I, R158S, E484K, N764K; nsp12: G671S; nsp13: P77L; nsp3: S1475G; nsp4: I27T, T354A, A380V, R400S; nsp6: S106-, G107-, F108-","spike_mutations":"L18R, H69-, V70-, T95I, R158S, E484K, N764K"}}},{"name":"NODE_0000443","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.440206527709961}},"branch_attrs":{"mutations":{"nuc":["C24642T"],"S":["T1027I"]},"labels":{"aa":"S: T1027I","spike_mutations":"T1027I"}},"children":[{"name":"B.1.636","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.636"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","C5907T","C5986T","A9085G","C11289-","G11291-","G11292-","C21614T","A22005C","G23867A","C25931T","-26161A","C27925T","A28295T","A28742G","G29734C"],"N":["N8Y","I157V"],"ORF3a":["S180F"],"ORF8":["T11I"],"ORF9b":["K4N"],"S":["L18F","N148T","G769R"],"nsp3":["T1063I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: N8Y, I157V; ORF3a: S180F; ORF8: T11I; ORF9b: K4N; S: L18F, N148T, G769R; nsp3: T1063I; nsp6: S106-, G107-, F108-","spike_mutations":"L18F, N148T, G769R"}}},{"name":"NODE_0000444","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A994G","G9756A","C9924T","A10982G","G11283-","T11284-","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C23604A","T23765G","C24442T","G26158-","T26159-","T26160-","C26222T"],"ORF3a":["V256-","N257-"],"S":["P681H","S735A"],"nsp4":["R401H","A457V"],"nsp6":["K4E","S104-"]},"labels":{"aa":"ORF3a: V256-, N257-; S: P681H, S735A; nsp4: R401H, A457V; nsp6: K4E, S104-","spike_mutations":"P681H, S735A"}},"children":[{"name":"B.1.627","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.627"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.627"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C1912T","C7869T","C9611T","T11285-","T20124A","T21752A","T22020C","C28923T","T29576-","T29577-","C29578-","G29579-","C29580-","T29581-","T29582-"],"N":["A217V"],"ORF10":["F7-","A8-","F9-"],"S":["W64R","M153T"],"nsp3":["S1717L"],"nsp4":["L353F"],"nsp6":["L105M"]},"labels":{"aa":"N: A217V; ORF10: F7-, A8-, F9-; S: W64R, M153T; nsp3: S1717L; nsp4: L353F; nsp6: L105M","spike_mutations":"W64R, M153T"}}},{"name":"B.1.631","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.631"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.631"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C829T","C4534T","C6120T","G7787A","A11282-","T21615G","C21846T","A22036C","C22916A","C25465T","C27769T","A28271-","A28330G","C28830T","G28907T","C28957T"],"N":["S186F","G212C"],"ORF3a":["P25S"],"ORF7b":["S5L"],"ORF9b":["D16G"],"S":["L18R","T95I","R158S","L452M"],"nsp3":["S1134L","A1690T"]},"labels":{"aa":"N: S186F, G212C; ORF3a: P25S; ORF7b: S5L; ORF9b: D16G; S: L18R, T95I, R158S, L452M; nsp3: S1134L, A1690T","spike_mutations":"L18R, T95I, R158S, L452M"}}}]}]}]},{"name":"NODE_0000445","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.317669153213501}},"branch_attrs":{"mutations":{"nuc":["C2416T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.279","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.279"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.279"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.854539155960083}},"branch_attrs":{"mutations":{"nuc":["C1913T","G2528A","C12525T","C16806T","G20014T","A25718G"],"ORF3a":["Y109C"],"nsp15":["D132Y"],"nsp2":["R370C","E575K"],"nsp8":["T145I"]},"labels":{"aa":"ORF3a: Y109C; nsp15: D132Y; nsp2: R370C, E575K; nsp8: T145I"}}},{"name":"NODE_0000446","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.214023113250732}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.389","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.389"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.389"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G8371T","C9430T","A15477T","C18395T","A20622T","G20623T","A20624T","C23730T","A26319G","G29044A"],"S":["T723I"],"nsp14":["A119V"],"nsp15":["K334N","D335F"],"nsp3":["Q1884H"]},"labels":{"aa":"S: T723I; nsp14: A119V; nsp15: K334N, D335F; nsp3: Q1884H","spike_mutations":"T723I"}}},{"name":"B.1.480","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.480"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.480"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.699550151824951}},"branch_attrs":{"mutations":{"nuc":["C875T","A10904G","G25249T"],"S":["M1229I"],"nsp2":["L24F"],"nsp5":["S284G"]},"labels":{"aa":"S: M1229I; nsp2: L24F; nsp5: S284G","spike_mutations":"M1229I"}}}]},{"name":"NODE_0000447","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.958614826202393}},"branch_attrs":{"mutations":{"nuc":["C14322T","C23604A","G23948T","T26038C"],"ORF3a":["S216P"],"S":["P681H","D796Y"]},"labels":{"aa":"ORF3a: S216P; S: P681H, D796Y","spike_mutations":"P681H, D796Y"}},"children":[{"name":"B.1.474","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.474"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.474"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.585630416870117}},"branch_attrs":{"mutations":{"nuc":["C539T","C5884T","C7834T","G8618A","C15579T","G16912T","C25207T","C26600T","C27970A","C28887T"],"N":["T205I"],"ORF8":["T26N"],"nsp1":["L92F"],"nsp13":["V226L"],"nsp4":["A22T"]},"labels":{"aa":"N: T205I; ORF8: T26N; nsp1: L92F; nsp13: V226L; nsp4: A22T"}}},{"name":"B.1.629","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.629"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.629"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C815T","C1191T","C3040T","A4229C","T5095C","C5178T","G11128A","C12459T","G21987A","A22107G","T22917G","C22995A","G25266T","C25433T","T26498C","T26767G","A28482G","C28833T","C28926T"],"M":["I82S"],"N":["Q70R","S187L","A218V"],"ORF3a":["T14I"],"ORF9b":["K67E"],"S":["G142D","K182R","L452R","T478K","C1235F"],"nsp2":["R4C","P129L"],"nsp3":["T504P","T820I"],"nsp6":["M52I"],"nsp8":["T123I"]},"labels":{"aa":"M: I82S; N: Q70R, S187L, A218V; ORF3a: T14I; ORF9b: K67E; S: G142D, K182R, L452R, T478K, C1235F; nsp2: R4C, P129L; nsp3: T504P, T820I; nsp6: M52I; nsp8: T123I","spike_mutations":"G142D, K182R, L452R, T478K, C1235F"}}}]}]},{"name":"NODE_0000448","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.357755661010742}},"branch_attrs":{"mutations":{"nuc":["C15324T"]}},"children":[{"name":"B.1.146","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.146"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.146"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C10833T","G28747T","G28917T","G29543T"],"N":["G215V"],"nsp5":["A260V"]},"labels":{"aa":"N: G215V; nsp5: A260V"}}},{"name":"B.1.147","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.147"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.147"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.98856782913208}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"B.1.149","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.149"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.149"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.820705890655518}},"branch_attrs":{"mutations":{"nuc":["G16846T"],"nsp13":["D204Y"]},"labels":{"aa":"nsp13: D204Y"}}},{"name":"B.1.210","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.210"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.210"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.527243614196777}},"branch_attrs":{"mutations":{"nuc":["A1C","C3634T"]}}},{"name":"B.1.212","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.212"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.212"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.8698015213012695}},"branch_attrs":{"mutations":{"nuc":["C16428T"]}}},{"name":"B.1.221","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.221"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.221"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.022773027420044}},"branch_attrs":{"mutations":{"nuc":["C3602T","C6941T","C21855T","A25505G","G25906C","G25996T","C28651T","C28869T"],"N":["P199L"],"ORF3a":["Q38R","G172R","V202L"],"S":["S98F"],"nsp3":["H295Y"]},"labels":{"aa":"N: P199L; ORF3a: Q38R, G172R, V202L; S: S98F; nsp3: H295Y","spike_mutations":"S98F"}}},{"name":"B.1.219","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.219"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.219"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.373754501342773}},"branch_attrs":{"mutations":{"nuc":["T13A","C16193T","A22404T"],"S":["E281V"],"nsp12":["P918L"]},"labels":{"aa":"S: E281V; nsp12: P918L","spike_mutations":"E281V"}}},{"name":"B.1.620","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.620"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.620"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A22T","C1473T","G6236A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G17110T","T20049C","C21638T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21939C","T21992-","A21993-","T21994-","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","C22295T","C22498T","G22992A","G23012A","A23416T","C23604A","C24642T","G24914C","A28271T","T28297C","C28932T"],"N":["A220V"],"ORF9b":["I5T"],"S":["P26S","H69-","V70-","V126A","Y144-","L241-","L242-","A243-","H245Y","S477N","E484K","P681H","T1027I","D1118H"],"nsp13":["A292S"],"nsp2":["T223I"],"nsp3":["V1173I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: A220V; ORF9b: I5T; S: P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H; nsp13: A292S; nsp2: T223I; nsp3: V1173I; nsp6: S106-, G107-, F108-","spike_mutations":"P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H"}}}]},{"name":"NODE_0000449","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9689385890960693}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.530","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.530"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.530"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G61T","A3291G","C11050T","G16935T","A19339G","C23604A","C26549T","T29471C"],"S":["P681H"],"nsp13":["M233I"],"nsp14":["S434G"],"nsp3":["Q191R"]},"labels":{"aa":"S: P681H; nsp13: M233I; nsp14: S434G; nsp3: Q191R","spike_mutations":"P681H"}}},{"name":"NODE_0000450","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.214"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-7.439484119415283}},"branch_attrs":{"mutations":{"nuc":["A4457G","C5907T","C12312T","C15324T"],"nsp3":["I580V","T1063I"],"nsp8":["A74V"]},"labels":{"aa":"nsp3: I580V, T1063I; nsp8: A74V"}},"children":[{"name":"B.1.214.1","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.214.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.222192764282227}},"branch_attrs":{"mutations":{"nuc":["A481G","C5144T","C17304G","C17999T"],"nsp13":["T588I"]},"labels":{"aa":"nsp13: T588I"}}},{"name":"B.1.214","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.214"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.219902992248535}},"branch_attrs":{"mutations":{"nuc":["T28887C"],"N":["I205T"]},"labels":{"aa":"N: I205T"}}},{"name":"NODE_0000451","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.214"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C4891T","A15187G","C23709T","T27576C","G28280C","A28281T","T28282A","C28846T"],"N":["D3L"],"S":["T716I"],"nsp12":["R583G"]},"labels":{"aa":"N: D3L; S: T716I; nsp12: R583G","spike_mutations":"T716I"}},"children":[{"name":"B.1.214.2","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.214.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:29-276"},"designation_date":{"value":"2021-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9553585052490234}},"branch_attrs":{"mutations":{"nuc":["C22802A","T22912G","A25448-","A25449-","A25450-","T25451-","C25452-","A25453-","A25454-","G25455-","G25456-","A25457-","T25458-","G25459-","C25460-","T25461-","A25462-","C25463-","T25464-","C25465-","C25466-","T25467-","T25468-","C25469-","A25470-","G25471-","A25472-","T25473-","T25474-","T25475-"],"ORF3a":["E19-","I20-","K21-","D22-","A23-","T24-","P25-","S26-","D27-","F28-"],"S":["Q414K","N450K"]},"labels":{"aa":"ORF3a: E19-, I20-, K21-, D22-, A23-, T24-, P25-, S26-, D27-, F28-; S: Q414K, N450K","spike_mutations":"Q414K, N450K"}}},{"name":"B.1.214.3","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.214.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C673T","A11282-","G11283-","T11284-","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291T","A11430G","C21846T"],"S":["T95I"],"nsp6":["S104-","L105-","S106-","G107C","Y153C"]},"labels":{"aa":"S: T95I; nsp6: S104-, L105-, S106-, G107C, Y153C","spike_mutations":"T95I"}}}]}]},{"name":"NODE_0000452","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.162606716156006}},"branch_attrs":{"mutations":{"nuc":["T26767C"],"M":["I82T"]},"labels":{"aa":"M: I82T"}},"children":[{"name":"NODE_0000453","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.605557441711426}},"branch_attrs":{"mutations":{"nuc":["C23604A","C24138A","A28271-"],"S":["P681H","T859N"]},"labels":{"aa":"S: P681H, T859N","spike_mutations":"P681H, T859N"}},"children":[{"name":"B.1.415.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.415.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.415.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1150T","T7185C","C8251T","A11023T","A11217G","C13458T","G15732T","T16348C","A16619G","A18410G","T19143C","A20268G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C22286-","T22287-","T22288-","G22299C","G22599A","G23012A","A23064C","C24507T","G26840T","G28178A","G28302A","C28932T"],"N":["R10Q","A220V"],"ORF9b":["E7K"],"S":["H69-","V70-","L241-","R246T","R346K","E484K","N501T","S982L"],"nsp11":["S6L"],"nsp12":["S6L"],"nsp13":["S38P","E128G"],"nsp14":["Y124C"],"nsp3":["I1489T"],"nsp6":["N82S"]},"labels":{"aa":"N: R10Q, A220V; ORF9b: E7K; S: H69-, V70-, L241-, R246T, R346K, E484K, N501T, S982L; nsp11: S6L; nsp12: S6L; nsp13: S38P, E128G; nsp14: Y124C; nsp3: I1489T; nsp6: N82S","spike_mutations":"H69-, V70-, L241-, R246T, R346K, E484K, N501T, S982L"}}},{"name":"B.1.640.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"B.1.640.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.640.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C601T","C1191T","A1620G","C2416T","C2455T","G6622T","C9711T","G9756A","C10029T","T11418C","C11956T","C16575T","C16869T","C20283T","C21588T","G21848C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","G22132T","T22191C","A22600C","A22743G","T22907A","T23030C","T23031G","A23063T","G24368C","C25487T","G25563T","A26492T","C27513T","C27807T","C27972T","T28297C","G28337T","T29377C","G29405C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","G29779T"],"N":["D22Y","E378Q"],"ORF3a":["T32I","Q57H"],"ORF8":["Q27*"],"ORF9b":["I5T","Q18H"],"S":["P9L","E96Q","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","R190S","I210T","R346S","N394S","Y449N","F490R","N501Y","D936H"],"nsp2":["P129L","E272G"],"nsp3":["L1301F"],"nsp4":["S386F","R401H","T492I"],"nsp6":["V149A"]},"labels":{"aa":"N: D22Y, E378Q; ORF3a: T32I, Q57H; ORF8: Q27*; ORF9b: I5T, Q18H; S: P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, R190S, I210T, R346S, N394S, Y449N, F490R, N501Y, D936H; nsp2: P129L, E272G; nsp3: L1301F; nsp4: S386F, R401H, T492I; nsp6: V149A","spike_mutations":"P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, R190S, I210T, R346S, N394S, Y449N, F490R, N501Y, D936H"}}}]},{"name":"NODE_0000454","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.619"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2407A","G5008T","C6633T","G8084A","C8311T","C9319T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11521T","C12473T","C14403T","C15324T","G19962A","C21637T","T22191C","T22882G","G23012A","T24194C","G24368A","C24378T","C24642T","G26211T","C26606T","G27459T","C28311T","G28875T"],"N":["P13L","S201I"],"ORF7a":["E22D"],"ORF9b":["P10S"],"S":["I210T","N440K","E484K","D936N","S939F","T1027I"],"nsp3":["A1305V","E1789K"],"nsp6":["S106-","G107-","F108-","M183I"]},"labels":{"aa":"N: P13L, S201I; ORF7a: E22D; ORF9b: P10S; S: I210T, N440K, E484K, D936N, S939F, T1027I; nsp3: A1305V, E1789K; nsp6: S106-, G107-, F108-, M183I","spike_mutations":"I210T, N440K, E484K, D936N, S939F, T1027I"}},"children":[{"name":"B.1.619","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.619"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"B.1.619.1","node_attrs":{"div":38,"Nextclade_pango":{"value":"B.1.619.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C19T","T5701C","A12051G","A21213G","T22738C","A28271-","C28441T","T28600C","C28957T"],"ORF9b":["S53L"],"nsp7":["K70R"]},"labels":{"aa":"ORF9b: S53L; nsp7: K70R"}}}]}]}]},{"name":"NODE_0000455","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.1044530868530273}},"branch_attrs":{"mutations":{"nuc":["T445C","C6286T","G21255C","C22227T","C26801G","C28932T","G29645T"],"N":["A220V"],"ORF10":["V30L"],"S":["A222V"]},"labels":{"aa":"N: A220V; ORF10: V30L; S: A222V","clade":"20E","spike_mutations":"A222V"}},"children":[{"name":"B.1.177","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.177"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.1044530868530273}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.15","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.15"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.15"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.812208652496338}},"branch_attrs":{"mutations":{"nuc":["C5170T","C10078T","G11132T","G11417T","G22051T","G29179T"],"nsp6":["A54S","V149F"]},"labels":{"aa":"nsp6: A54S, V149F"}}},{"name":"B.1.177.18","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.18"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.1767425537109375}},"branch_attrs":{"mutations":{"nuc":["A10323G","G23311C","G25440T","C27752T"],"ORF3a":["K16N"],"ORF7a":["T120I"],"S":["E583D"],"nsp5":["K90R"]},"labels":{"aa":"ORF3a: K16N; ORF7a: T120I; S: E583D; nsp5: K90R","spike_mutations":"E583D"}}},{"name":"B.1.177.16","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.16"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.051562786102295}},"branch_attrs":{"mutations":{"nuc":["C28310A"],"N":["P13T"],"ORF9b":["H9Q"]},"labels":{"aa":"N: P13T; ORF9b: H9Q"}}},{"name":"B.1.177.32","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.32"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.204548358917236}},"branch_attrs":{"mutations":{"nuc":["C5700T","C11152T"],"nsp3":["A994V"]},"labels":{"aa":"nsp3: A994V"}}},{"name":"B.1.177.73","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.73"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.73"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.086843013763428}},"branch_attrs":{"mutations":{"nuc":["G1820A","A2473G","T7543C","C13671T","A24774T","C26060A"],"ORF3a":["T223N"],"S":["Q1071L"],"nsp2":["G339S"]},"labels":{"aa":"ORF3a: T223N; S: Q1071L; nsp2: G339S","spike_mutations":"Q1071L"}}},{"name":"B.1.177.75","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.75"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.75"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.156762599945068}},"branch_attrs":{"mutations":{"nuc":["A1C","T8284C"]}}},{"name":"NODE_0000456","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.143012046813965}},"branch_attrs":{"mutations":{"nuc":["C222T","T20661C","C29386T"]}},"children":[{"name":"B.1.177.44","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.44"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.44"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.074658393859863}},"branch_attrs":{"mutations":{"nuc":["G21468T"],"nsp16":["M270I"]},"labels":{"aa":"nsp16: M270I"}}},{"name":"NODE_0000457","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.473905563354492}},"branch_attrs":{"mutations":{"nuc":["C29366T"],"N":["P365S"]},"labels":{"aa":"N: P365S"}},"children":[{"name":"B.1.177.12","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.12"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.12"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.39573073387146}},"branch_attrs":{"mutations":{"nuc":["T24814C","G25757T"],"ORF3a":["R122I"]},"labels":{"aa":"ORF3a: R122I"}}},{"name":"B.1.177.35","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.35"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.8779044151306152}},"branch_attrs":{"mutations":{"nuc":["T26966C"]}}}]}]},{"name":"NODE_0000458","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.924924850463867}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}},"children":[{"name":"B.1.177.10","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.10"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.106119155883789}},"branch_attrs":{"mutations":{"nuc":["G28321A"],"ORF9b":["R13H"]},"labels":{"aa":"ORF9b: R13H"}}},{"name":"B.1.177.46","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.46"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.46"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.15555477142334}},"branch_attrs":{"mutations":{"nuc":["C9693T","C18508T","G29179T"],"nsp14":["L157F"],"nsp4":["A380V"]},"labels":{"aa":"nsp14: L157F; nsp4: A380V"}}},{"name":"NODE_0000459","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4437451362609863}},"branch_attrs":{"mutations":{"nuc":["C1513T","C22377T"],"S":["P272L"]},"labels":{"aa":"S: P272L","spike_mutations":"P272L"}},"children":[{"name":"B.1.177.82","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.82"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.82"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.837984561920166}},"branch_attrs":{"mutations":{"nuc":["G28378T","G29757T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.177.83","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.83"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.83"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.299724578857422}},"branch_attrs":{"mutations":{"nuc":["C2062T"]}}},{"name":"B.1.177.87","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.87"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.87"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.9360873699188232}},"branch_attrs":{"mutations":{"nuc":["C28706T","C29095T"],"N":["H145Y"]},"labels":{"aa":"N: H145Y"}}}]}]},{"name":"NODE_0000460","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.161717653274536}},"branch_attrs":{"mutations":{"nuc":["C27944T"]}},"children":[{"name":"B.1.177.4","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.4"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.478666067123413}},"branch_attrs":{"mutations":{"nuc":["C66T","A1987G","G10870T","C25614T"]}}},{"name":"B.1.177.52","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.52"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.52"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.295443534851074}},"branch_attrs":{"mutations":{"nuc":["A1T","G5023T","C25047G"],"S":["P1162R"],"nsp3":["M768I"]},"labels":{"aa":"S: P1162R; nsp3: M768I","spike_mutations":"P1162R"}}},{"name":"B.1.177.81","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.81"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.81"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.3990318775177}},"branch_attrs":{"mutations":{"nuc":["C12119T","A21222T","C25889T"],"ORF3a":["S166L"],"nsp8":["P10S"]},"labels":{"aa":"ORF3a: S166L; nsp8: P10S"}}},{"name":"NODE_0000461","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.53"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.278009414672852}},"branch_attrs":{"mutations":{"nuc":["C2973T","G9805T"],"nsp3":["A85V"]},"labels":{"aa":"nsp3: A85V"}},"children":[{"name":"B.1.177.53","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.53"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.278009414672852}},"branch_attrs":{"mutations":{}}},{"name":"W.1","node_attrs":{"div":18,"Nextclade_pango":{"value":"W.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53.1"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-5.000479221343994}},"branch_attrs":{"mutations":{"nuc":["C17463T","C17676T","T24799C","G25785T"],"ORF3a":["W131C"]},"labels":{"aa":"ORF3a: W131C"}}}]},{"name":"NODE_0000462","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.13129186630249}},"branch_attrs":{"mutations":{"nuc":["G204T"]}},"children":[{"name":"B.1.177.21","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.21"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.21"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.0787036418914795}},"branch_attrs":{"mutations":{"nuc":["T16242A"]}}},{"name":"B.1.177.77","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.77"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.77"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.0452117919921875}},"branch_attrs":{"mutations":{"nuc":["T3592C","C13517T"],"nsp12":["T26I"]},"labels":{"aa":"nsp12: T26I"}}},{"name":"NODE_0000463","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.644141674041748}},"branch_attrs":{"mutations":{"nuc":["C9745T"]}},"children":[{"name":"B.1.177.54","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.177.54"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.54"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.974447011947632}},"branch_attrs":{"mutations":{"nuc":["C23644T","T25878C","G25879A","A25881T"],"ORF3a":["V163I"]},"labels":{"aa":"ORF3a: V163I"}}},{"name":"NODE_0000464","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.35325288772583}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"nsp3":["A1736V"]},"labels":{"aa":"nsp3: A1736V"}},"children":[{"name":"B.1.177.57","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.57"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.57"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.707308769226074}},"branch_attrs":{"mutations":{"nuc":["C6807T"],"nsp3":["T1363I"]},"labels":{"aa":"nsp3: T1363I"}}},{"name":"B.1.177.56","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.56"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.56"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.35325288772583}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000465","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-2.566998243331909}},"branch_attrs":{"mutations":{"nuc":["C21614T"],"S":["L18F"]},"labels":{"aa":"S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.177.5","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.5"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.151096820831299}},"branch_attrs":{"mutations":{"nuc":["T24769C","C25460T"],"ORF3a":["A23V"]},"labels":{"aa":"ORF3a: A23V"}}},{"name":"B.1.177.60","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.60"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.60"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.3496036529541016}},"branch_attrs":{"mutations":{"nuc":["A1G","G25621T"],"ORF3a":["V77F"]},"labels":{"aa":"ORF3a: V77F"}}},{"name":"B.1.177.62","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.177.62"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.62"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.268250465393066}},"branch_attrs":{"mutations":{"nuc":["C7195T","C21714T","G24368T","G25855T"],"ORF3a":["D155Y"],"S":["T51I","D936Y"]},"labels":{"aa":"ORF3a: D155Y; S: T51I, D936Y","spike_mutations":"T51I, D936Y"}}},{"name":"B.1.177.7","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.7"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.7"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4441723823547363}},"branch_attrs":{"mutations":{"nuc":["C15480T"]}}},{"name":"B.1.177.8","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.8"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.112913131713867}},"branch_attrs":{"mutations":{"nuc":["G8179T"]}}},{"name":"B.1.177.86","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.86"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.86"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4548094272613525}},"branch_attrs":{"mutations":{"nuc":["C6040T","G26801T","G27870T"],"ORF7b":["E39*"]},"labels":{"aa":"ORF7b: E39*"}}}]}]}]}]},{"name":"NODE_0000466","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.2661590576171875}},"branch_attrs":{"mutations":{"nuc":["A20268G"]}},"children":[{"name":"B.1.189","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.189"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.189"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.054994106292725}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.192","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.192"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.192"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.370109558105469}},"branch_attrs":{"mutations":{"nuc":["C11833T"]}}},{"name":"B.1.237","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.237"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.237"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.828962326049805}},"branch_attrs":{"mutations":{"nuc":["G2164C"],"nsp2":["E453D"]},"labels":{"aa":"nsp2: E453D"}}},{"name":"B.1.381","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.381"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.381"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.034300327301025}},"branch_attrs":{"mutations":{"nuc":["C355T","C4093T"]}}},{"name":"B.1.420","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.420"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.420"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.054104328155518}},"branch_attrs":{"mutations":{"nuc":["T23443C"]}}},{"name":"B.1.417","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.417"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.417"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.156829357147217}},"branch_attrs":{"mutations":{"nuc":["T5422C","C7051T","G7743T","C12880T"],"nsp3":["S1675I"]},"labels":{"aa":"nsp3: S1675I"}}},{"name":"B.1.600","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.600"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.600"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.995579719543457}},"branch_attrs":{"mutations":{"nuc":["A5G","A6G","G7A","C5784T","C27982T"],"ORF8":["P30L"],"nsp3":["T1022I"]},"labels":{"aa":"ORF8: P30L; nsp3: T1022I"}}},{"name":"B.1.609","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.609"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.609"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.865769147872925}},"branch_attrs":{"mutations":{"nuc":["C4582T"]}}},{"name":"NODE_0000467","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.416"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.642777442932129}},"branch_attrs":{"mutations":{"nuc":["A1C","C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}},"children":[{"name":"B.1.416","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.416"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.278482437133789}},"branch_attrs":{"mutations":{"nuc":["C1625T"],"nsp2":["L274F"]},"labels":{"aa":"nsp2: L274F"}}},{"name":"B.1.416.1","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.416.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.303077220916748}},"branch_attrs":{"mutations":{"nuc":["C25731T"]}}}]},{"name":"NODE_0000468","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{"nuc":["A1G","T7767C","C8047T","C17104T","C22879A","G29734C"],"S":["N439K"],"nsp13":["H290Y"],"nsp3":["I1683T"]},"labels":{"aa":"S: N439K; nsp13: H290Y; nsp3: I1683T","spike_mutations":"N439K"}},"children":[{"name":"B.1.258","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.258"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{}}},{"name":"B.1.258.3","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.258.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.964566469192505}},"branch_attrs":{"mutations":{"nuc":["G1464A","A10978T","G18803T","T20799C"],"nsp14":["S255I"],"nsp2":["G220D"]},"labels":{"aa":"nsp14: S255I; nsp2: G220D"}}},{"name":"NODE_0000469","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.993483066558838}},"branch_attrs":{"mutations":{"nuc":["C27800A"]}},"children":[{"name":"B.1.258.14","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.258.14"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.14"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.224915981292725}},"branch_attrs":{"mutations":{"nuc":["G1A","C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}}},{"name":"NODE_0000470","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.193143606185913}},"branch_attrs":{"mutations":{"nuc":["G12988T","G15598A","G18028T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T24910C","T26972C"],"S":["H69-","V70-"],"nsp12":["V720I"],"nsp13":["A598S"],"nsp9":["M101I"]},"labels":{"aa":"S: H69-, V70-; nsp12: V720I; nsp13: A598S; nsp9: M101I","spike_mutations":"H69-, V70-"}},"children":[{"name":"B.1.258.11","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.258.11"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.11"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.367208480834961}},"branch_attrs":{"mutations":{"nuc":["C12455T","C20451T"],"nsp8":["L122F"]},"labels":{"aa":"nsp8: L122F"}}},{"name":"B.1.258.17","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.258.17"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.17"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.1944985389709473}},"branch_attrs":{"mutations":{"nuc":["C829T","C14697T","C16394T","C18176T","G19398T","C22127T","G23876A","G25947T"],"ORF3a":["Q185H"],"S":["L189F","V772I"],"nsp13":["P53L"],"nsp14":["P46L","E453D"]},"labels":{"aa":"ORF3a: Q185H; S: L189F, V772I; nsp13: P53L; nsp14: P46L, E453D","spike_mutations":"L189F, V772I"}}}]}]}]},{"name":"NODE_0000471","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.039437770843506}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.232","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.232"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.232"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8121721744537354}},"branch_attrs":{"mutations":{"nuc":["G27987T"],"ORF8":["V32L"]},"labels":{"aa":"ORF8: V32L"}}},{"name":"B.1.234","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.234"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.234"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.2358059883117676}},"branch_attrs":{"mutations":{"nuc":["G2258A","A6441G","C8140T","A9204G"],"nsp2":["V485I"],"nsp3":["K1241R"],"nsp4":["D217G"]},"labels":{"aa":"nsp2: V485I; nsp3: K1241R; nsp4: D217G"}}},{"name":"B.1.239","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.239"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.239"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.158753395080566}},"branch_attrs":{"mutations":{"nuc":["G16741A"],"nsp13":["V169I"]},"labels":{"aa":"nsp13: V169I"}}},{"name":"B.1.236","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.236"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.236"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.485028266906738}},"branch_attrs":{"mutations":{"nuc":["G11842A","A12759G","G18292T"],"nsp14":["A85S"],"nsp9":["D25G"]},"labels":{"aa":"nsp14: A85S; nsp9: D25G"}}},{"name":"B.1.243","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.243"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.243"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.000774383544922}},"branch_attrs":{"mutations":{"nuc":["T24076C"]}}},{"name":"B.1.241","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.241"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.241"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9246673583984375}},"branch_attrs":{"mutations":{"nuc":["C11575T"]}}},{"name":"B.1.397","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.397"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.397"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.800171375274658}},"branch_attrs":{"mutations":{"nuc":["G1135T"],"nsp2":["K110N"]},"labels":{"aa":"nsp2: K110N"}}},{"name":"B.1.398","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.398"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.398"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.523492813110352}},"branch_attrs":{"mutations":{"nuc":["G4136A","C11224T","C12295A","C21846T"],"S":["T95I"],"nsp3":["V473I"]},"labels":{"aa":"S: T95I; nsp3: V473I","spike_mutations":"T95I"}}},{"name":"B.1.396","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.396"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.396"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1198410987854}},"branch_attrs":{"mutations":{"nuc":["C1191T","C9521A","C24904T","G29422T","A29567G"],"ORF10":["I4V"],"nsp2":["P129L"],"nsp4":["L323I"]},"labels":{"aa":"ORF10: I4V; nsp2: P129L; nsp4: L323I"}}},{"name":"B.1.399","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.399"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.399"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.258176326751709}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}}},{"name":"B.1.400","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.400"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.400"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.643618583679199}},"branch_attrs":{"mutations":{"nuc":["G19969A"],"nsp15":["A117T"]},"labels":{"aa":"nsp15: A117T"}}},{"name":"B.1.402","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.402"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.402"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.080169677734375}},"branch_attrs":{"mutations":{"nuc":["C4633T","T14643C","C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"B.1.409","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.409"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.409"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1198410987854}},"branch_attrs":{"mutations":{"nuc":["G3527A","G5015A","A5877G","G8017T","C11008T","C20283T","C25714T","G25855T","C27434T","C27998T"],"ORF3a":["L108F","D155Y"],"ORF7a":["T14I"],"nsp3":["D270N","V766M","N1053S"]},"labels":{"aa":"ORF3a: L108F, D155Y; ORF7a: T14I; nsp3: D270N, V766M, N1053S"}}},{"name":"B.1.551","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.551"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.551"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.054353713989258}},"branch_attrs":{"mutations":{"nuc":["C3738T","C23604G"],"S":["P681R"],"nsp3":["P340L"]},"labels":{"aa":"S: P681R; nsp3: P340L","spike_mutations":"P681R"}}},{"name":"B.1.558","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.558"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.558"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.004430770874023}},"branch_attrs":{"mutations":{"nuc":["C1288T"]}}},{"name":"NODE_0000472","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.240"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.6813478469848633}},"branch_attrs":{"mutations":{"nuc":["C18486T","T22162C"]}},"children":[{"name":"B.1.240","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.240"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.6813478469848633}},"branch_attrs":{"mutations":{}}},{"name":"B.1.240.1","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.240.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-8.332109451293945}},"branch_attrs":{"mutations":{"nuc":["G10610T","G10870T","G11335T","C14262T","G29494A"],"nsp5":["V186F"]},"labels":{"aa":"nsp5: V186F"}}}]},{"name":"NODE_0000473","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.489289283752441}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"B.1.404","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.404"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.404"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["G5572T","G7042T","A12644G","T16743C","G19086T","G22992A"],"S":["S477N"],"nsp14":["K349N"],"nsp3":["M951I","M1441I"],"nsp8":["I185V"]},"labels":{"aa":"S: S477N; nsp14: K349N; nsp3: M951I, M1441I; nsp8: I185V","spike_mutations":"S477N"}}},{"name":"B.1.561","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.561"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.561"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.697448492050171}},"branch_attrs":{"mutations":{"nuc":["G2516T","A5999G","C18693T","G21974T","T25577C","G28975T"],"N":["M234I"],"ORF3a":["I62T"],"S":["D138Y"],"nsp2":["V571L"],"nsp3":["I1094V"]},"labels":{"aa":"N: M234I; ORF3a: I62T; S: D138Y; nsp2: V571L; nsp3: I1094V","spike_mutations":"D138Y"}}}]}]}]},{"name":"NODE_0000474","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7314677238464355}},"branch_attrs":{"mutations":{"nuc":["C18877T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.111","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.111"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.111"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.20757532119751}},"branch_attrs":{"mutations":{"nuc":["C10507T"]}}},{"name":"B.1.170","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.170"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.170"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7314677238464355}},"branch_attrs":{"mutations":{}}},{"name":"B.1.436","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.436"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.436"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.123282432556152}},"branch_attrs":{"mutations":{"nuc":["C28890T","T29710A"],"N":["S206F"]},"labels":{"aa":"N: S206F"}}},{"name":"B.1.438","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.438"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.438"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.653946399688721}},"branch_attrs":{"mutations":{"nuc":["A1154G","G29474T"],"N":["D401Y"],"nsp2":["M117V"]},"labels":{"aa":"N: D401Y; nsp2: M117V"}}},{"name":"B.1.441","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.441"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.441"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.796097755432129}},"branch_attrs":{"mutations":{"nuc":["T8296C","G28690T"],"N":["L139F"]},"labels":{"aa":"N: L139F"}}},{"name":"NODE_0000475","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.9"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.251059532165527}},"branch_attrs":{"mutations":{"nuc":["C7765T","C17690T"],"nsp13":["S485L"]},"labels":{"aa":"nsp13: S485L"}},"children":[{"name":"B.1.9","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.655979633331299}},"branch_attrs":{"mutations":{"nuc":["C2113T"]}}},{"name":"B.1.9.5","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9.5"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.251059532165527}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000476","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.02042293548584}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}},"children":[{"name":"B.1.459","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.459"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.459"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.765696048736572}},"branch_attrs":{"mutations":{"nuc":["C5184T"],"nsp3":["P822L"]},"labels":{"aa":"nsp3: P822L"}}},{"name":"B.1.462","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.462"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.462"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.719885349273682}},"branch_attrs":{"mutations":{"nuc":["C3811T"]}}},{"name":"B.1.465","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.465"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.465"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.7676591873168945}},"branch_attrs":{"mutations":{"nuc":["G24197T"],"S":["A879S"]},"labels":{"aa":"S: A879S","spike_mutations":"A879S"}}},{"name":"B.1.469","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.469"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.469"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.699280738830566}},"branch_attrs":{"mutations":{"nuc":["A12075G","A21137G","C28866T"],"N":["T198I"],"nsp16":["K160R"],"nsp7":["N78S"]},"labels":{"aa":"N: T198I; nsp16: K160R; nsp7: N78S"}}},{"name":"B.1.471","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.471"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.471"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.839853286743164}},"branch_attrs":{"mutations":{"nuc":["C16915T","T24202C"]}}},{"name":"B.1.470","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.470"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.470"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.865800857543945}},"branch_attrs":{"mutations":{"nuc":["C14120T"],"nsp12":["P227L"]},"labels":{"aa":"nsp12: P227L"}}},{"name":"NODE_0000477","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.160"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-2.896782875061035}},"branch_attrs":{"mutations":{"nuc":["C4543T","G5629T","G9526T","C11497T","G13993T","G15766T","A16889G","G17019T","G22992A","C25710T","T26876C","G28975C","G29399A"],"N":["M234I","A376T"],"S":["S477N"],"nsp12":["A185S","V776L"],"nsp13":["K218R","E261D"],"nsp4":["M324I"]},"labels":{"aa":"N: M234I, A376T; S: S477N; nsp12: A185S, V776L; nsp13: K218R, E261D; nsp4: M324I","spike_mutations":"S477N"}},"children":[{"name":"B.1.160","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.160"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-2.896782875061035}},"branch_attrs":{"mutations":{}}},{"name":"B.1.160.16","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.160.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160.16"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.024463176727295}},"branch_attrs":{"mutations":{"nuc":["C27434T","C27964T","G29557T"],"ORF7a":["T14I"],"ORF8":["S24L"]},"labels":{"aa":"ORF7a: T14I; ORF8: S24L"}}}]},{"name":"NODE_0000478","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.627126216888428}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36.19","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.19"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.19"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.075583457946777}},"branch_attrs":{"mutations":{"nuc":["A1C","G28086T","C29614T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"B.1.456","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.456"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.456"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.627126216888428}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000479","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.466"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.84882926940918}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.466","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.466"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.84882926940918}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000480","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.466"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.935308456420898}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.466.1","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.466.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["A3423G","C6318A","C15026T","A19960G","G25526T","C25553T","C26111T","A29019G","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K249R"],"ORF3a":["W45L","A54V","P240L"],"nsp12":["A529V"],"nsp15":["T114A"],"nsp3":["K235R","P1200Q"]},"labels":{"aa":"N: K249R; ORF3a: W45L, A54V, P240L; nsp12: A529V; nsp15: T114A; nsp3: K235R, P1200Q"}}},{"name":"NODE_0000481","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.466.2"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.372191429138184}},"branch_attrs":{"mutations":{"nuc":["C3768T","C5184T"],"nsp3":["T350I","P822L"]},"labels":{"aa":"nsp3: T350I, P822L"}},"children":[{"name":"B.1.466.2","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.466.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.372191429138184}},"branch_attrs":{"mutations":{"nuc":["A29897T","A29898G","A29899G","A29902G"]}}},{"name":"NODE_0000482","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.466.2"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7382194995880127}},"branch_attrs":{"mutations":{"nuc":["C683T","C3096T","C11195T","C12880T","C17012T","T22219C","C23604G","C29718T","C29743T"],"S":["P681R"],"nsp13":["S259L"],"nsp3":["S126L"],"nsp6":["L75F"]},"labels":{"aa":"S: P681R; nsp13: S259L; nsp3: S126L; nsp6: L75F","spike_mutations":"P681R"}},"children":[{"name":"AU.2","node_attrs":{"div":24,"Nextclade_pango":{"value":"AU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.538213729858398}},"branch_attrs":{"mutations":{"nuc":["A11117G","C12439T","G20002T","G25314T"],"S":["G1251V"],"nsp15":["D128Y"],"nsp6":["I49V"]},"labels":{"aa":"S: G1251V; nsp15: D128Y; nsp6: I49V","spike_mutations":"G1251V"}}},{"name":"AU.3","node_attrs":{"div":23,"Nextclade_pango":{"value":"AU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.585630416870117}},"branch_attrs":{"mutations":{"nuc":["C8109T","C19586T","G29315C"],"N":["D348H"],"nsp14":["T516I"],"nsp3":["T1797I"]},"labels":{"aa":"N: D348H; nsp14: T516I; nsp3: T1797I"}}}]}]}]}]},{"name":"NODE_0000483","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.616693496704102}},"branch_attrs":{"mutations":{"nuc":["G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}},"children":[{"name":"B.1.523","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.523"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.523"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.616693496704102}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000484","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.105329990386963}},"branch_attrs":{"mutations":{"nuc":["T26735C","A28272G"]}},"children":[{"name":"B.1.438.1","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.438.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.438.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.225435256958008}},"branch_attrs":{"mutations":{"nuc":["A1154G","C8152T","A12121G","G23587T","G25677T","G29474T"],"N":["D401Y"],"ORF3a":["L95F"],"S":["Q675H"],"nsp2":["M117V"]},"labels":{"aa":"N: D401Y; ORF3a: L95F; S: Q675H; nsp2: M117V","spike_mutations":"Q675H"}}},{"name":"NODE_0000485","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.198151111602783}},"branch_attrs":{"mutations":{"nuc":["C21846T","A21993-","G23012A","G24410A"],"S":["T95I","Y144-","E484K","D950N"]},"labels":{"aa":"S: T95I, Y144-, E484K, D950N","spike_mutations":"T95I, Y144-, E484K, D950N"}},"children":[{"name":"B.1.625","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.625"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:4-122"},"designation_date":{"value":"2021-06-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.625"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["G521T","C2306T","A4220G","C5730T","C6401T","A10323G","C10775T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12730G","A13712G","C16694T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","T21994-","C22033A","T22882G","G25244T","T26767C","A27721G","A27897-","A27898-","A27899-","T27900-","T27901-"],"M":["I82T"],"ORF7a":["I110V"],"ORF8":["K2-","F3-"],"S":["H69-","V70-","F157L","N440K","V1228L"],"nsp1":["V86F"],"nsp12":["K91R"],"nsp13":["T153I"],"nsp2":["L501F"],"nsp3":["K501E","T1004I","P1228S"],"nsp5":["K90R","P241S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; ORF7a: I110V; ORF8: K2-, F3-; S: H69-, V70-, F157L, N440K, V1228L; nsp1: V86F; nsp12: K91R; nsp13: T153I; nsp2: L501F; nsp3: K501E, T1004I, P1228S; nsp5: K90R, P241S; nsp6: S106-, G107-, F108-","spike_mutations":"H69-, V70-, F157L, N440K, V1228L"}}},{"name":"NODE_0000486","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.621"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-3.4022560119628906}},"branch_attrs":{"mutations":{"nuc":["A3428G","C4878T","C6037T","C10029T","A11451G","A13057T","C17491T","T19035C","C20148T","-21993C","T21995A","G22599A","A23063T","C23604A","G26158-","T26159-","T26160-","A26161-","A26492T","C27925A","C28005T","C28093T","G28272T","C28887T","T28975G"],"N":["T205I","I234M"],"ORF3a":["V256-","N257-"],"ORF8":["T11K","P38S","S67F"],"S":["-144S","Y145N","R346K","N501Y","P681H"],"nsp13":["P419S"],"nsp3":["T237A","T720I"],"nsp4":["T492I"],"nsp6":["Q160R"]},"labels":{"aa":"N: T205I, I234M; ORF3a: V256-, N257-; ORF8: T11K, P38S, S67F; S: -144S, Y145N, R346K, N501Y, P681H; nsp13: P419S; nsp3: T237A, T720I; nsp4: T492I; nsp6: Q160R","clade":"Mu","spike_mutations":"-144S, Y145N, R346K, N501Y, P681H"}},"children":[{"name":"B.1.621","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.621"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-3.4022560119628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000487","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.621"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.116075038909912}},"branch_attrs":{"mutations":{"nuc":["C5192T","C17707T"],"nsp13":["P491S"]},"labels":{"aa":"nsp13: P491S"}},"children":[{"name":"B.1.621.2","node_attrs":{"div":44,"Nextclade_pango":{"value":"B.1.621.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2022-01-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.2"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["T177C","C2700T","T22907A","G23311T","G26959A","A27675C","G29736A","G29779T"],"M":["R146H"],"ORF7a":["Q94H"],"S":["Y449N","E583D"],"nsp2":["T632I"]},"labels":{"aa":"M: R146H; ORF7a: Q94H; S: Y449N, E583D; nsp2: T632I","spike_mutations":"Y449N, E583D"}}},{"name":"NODE_0000488","node_attrs":{"div":43,"Nextclade_pango":{"value":"B.1.621.1"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{"nuc":["A6704G","C9120T","C20402T","T22384A","G26167T","C28657T","T29748C"],"nsp15":["S261L"],"nsp3":["N1329D"],"nsp4":["T189I"]},"labels":{"aa":"nsp15: S261L; nsp3: N1329D; nsp4: T189I"}},"children":[{"name":"B.1.621.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"B.1.621.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{}}},{"name":"BB.2","node_attrs":{"div":47,"Nextclade_pango":{"value":"BB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1.2"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A6708G","C15963T","C24378T","C29409T"],"N":["T379I"],"S":["S939F"],"nsp3":["K1330R"]},"labels":{"aa":"N: T379I; S: S939F; nsp3: K1330R","spike_mutations":"S939F"}}}]}]}]}]}]}]},{"name":"NODE_0000489","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.841441631317139}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}},"children":[{"name":"B.1.468","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.468"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.468"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.841441631317139}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000490","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.1","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.350652694702148}},"branch_attrs":{"mutations":{"nuc":["C11224T","C11941T","C12043T"]}}},{"name":"B.1.36.10","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.10"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.16","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.16"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.127261638641357}},"branch_attrs":{"mutations":{"nuc":["A1T","G25494T"]}}},{"name":"B.1.36.22","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.22"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.22"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.128231525421143}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}}},{"name":"B.1.36.24","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.24"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.24"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.737695217132568}},"branch_attrs":{"mutations":{"nuc":["G22201T"]}}},{"name":"B.1.36.35","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.35"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.653663158416748}},"branch_attrs":{"mutations":{"nuc":["G25440T"],"ORF3a":["K16N"]},"labels":{"aa":"ORF3a: K16N"}}},{"name":"B.1.36.29","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.36.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.29"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8213653564453125}},"branch_attrs":{"mutations":{"nuc":["C3267T","C21034T","G26173T","G28183T","T28277C"],"N":["S2P"],"ORF3a":["E261*"],"ORF8":["S97I"],"nsp16":["L126F"],"nsp3":["T183I"]},"labels":{"aa":"N: S2P; ORF3a: E261*; ORF8: S97I; nsp16: L126F; nsp3: T183I"}}},{"name":"B.1.36.31","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.36.31"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.31"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1722T","A8512G","T9877C","G11222T","C12616T","C15738T","A21868T","C22227T","C25463T","G27561T","C28253T","C29095T"],"ORF3a":["T24I"],"S":["R102S","A222V"],"nsp2":["A306V"],"nsp6":["V84F"]},"labels":{"aa":"ORF3a: T24I; S: R102S, A222V; nsp2: A306V; nsp6: V84F","spike_mutations":"R102S, A222V"}}},{"name":"B.1.36.7","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.7"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.7"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.546401023864746}},"branch_attrs":{"mutations":{"nuc":["A11211G","A22190-","T22191-","T22192-"],"S":["I210-"],"nsp6":["Y80C"]},"labels":{"aa":"S: I210-; nsp6: Y80C","spike_mutations":"I210-"}}},{"name":"B.1.36.8","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.8"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.07541036605835}},"branch_attrs":{"mutations":{"nuc":["A1T","C2836T"]}}},{"name":"B.1.36.9","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.36.9"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["G2035T","C2523T","G3994A","C5730T","C9924T","G11083T","C11109T","A22190-","T22191-","T22192-","C24138A"],"S":["I210-","T859N"],"nsp2":["L410F","T573I"],"nsp3":["T1004I"],"nsp4":["A457V"],"nsp6":["L37F","A46V"]},"labels":{"aa":"S: I210-, T859N; nsp2: L410F, T573I; nsp3: T1004I; nsp4: A457V; nsp6: L37F, A46V","spike_mutations":"I210-, T859N"}}},{"name":"NODE_0000491","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.428178548812866}},"branch_attrs":{"mutations":{"nuc":["T1947C"],"nsp2":["V381A"]},"labels":{"aa":"nsp2: V381A"}},"children":[{"name":"B.1.36.36","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.36.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8934714794158936}},"branch_attrs":{"mutations":{"nuc":["C2668T","G4136T","C12141T","C19512T","C28292A","G29179T"],"N":["Q7K"],"nsp3":["V473F"],"nsp8":["T17I"]},"labels":{"aa":"N: Q7K; nsp3: V473F; nsp8: T17I"}}},{"name":"B.1.36.38","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.38"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.272319793701172}},"branch_attrs":{"mutations":{"nuc":["G22918T"]}}},{"name":"NODE_0000492","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.259950637817383}},"branch_attrs":{"mutations":{"nuc":["C29555T"]}},"children":[{"name":"B.1.36.18","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.36.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.18"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8423047065734863}},"branch_attrs":{"mutations":{"nuc":["G8027T","G15438T","C18981T","G21785C","C28093T"],"ORF8":["S67F"],"S":["G75R"],"nsp12":["M666I"],"nsp3":["V1770F"]},"labels":{"aa":"ORF8: S67F; S: G75R; nsp12: M666I; nsp3: V1770F","spike_mutations":"G75R"}}},{"name":"NODE_0000493","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}},"children":[{"name":"B.1.36.17","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36.17"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.17"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.39","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.36.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.39"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2319C","C6573T","C9936A","C15981T","C25904T"],"ORF3a":["S171L"],"nsp2":["F505S"],"nsp3":["S1285F"],"nsp4":["T461N"]},"labels":{"aa":"ORF3a: S171L; nsp2: F505S; nsp3: S1285F; nsp4: T461N"}}}]}]}]}]}]}]}]},{"name":"NODE_0000494","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-2.8577709197998047}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T"],"ORF3a":["Q57H"],"nsp2":["T85I"]},"labels":{"aa":"ORF3a: Q57H; nsp2: T85I","clade":"20C"}},"children":[{"name":"B.1.298","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.298"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.298"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.423281669616699}},"branch_attrs":{"mutations":{"nuc":["G5012T","C19488T","T28843G"],"N":["S190R"],"nsp3":["V765F"]},"labels":{"aa":"N: S190R; nsp3: V765F"}}},{"name":"B.1.320","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.320"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.320"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.057475566864014}},"branch_attrs":{"mutations":{"nuc":["A1G","C379A"]}}},{"name":"B.1.311","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.311"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.311"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.6200597286224365}},"branch_attrs":{"mutations":{"nuc":["A5011C","C12525T","C27920T","C28893T"],"N":["P207L"],"nsp3":["Q764H"],"nsp8":["T145I"]},"labels":{"aa":"N: P207L; nsp3: Q764H; nsp8: T145I"}}},{"name":"B.1.324","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.324"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.324"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.316860198974609}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}}},{"name":"B.1.319","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.319"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.319"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.238476753234863}},"branch_attrs":{"mutations":{"nuc":["C10851T"],"nsp5":["A266V"]},"labels":{"aa":"nsp5: A266V"}}},{"name":"B.1.340","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.340"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.340"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.6447930335998535}},"branch_attrs":{"mutations":{"nuc":["A4197G","A28715T"],"N":["T148S"],"nsp3":["E493G"]},"labels":{"aa":"N: T148S; nsp3: E493G"}}},{"name":"B.1.346","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.346"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.346"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A12820G","C16762T","A17637G","C20762T","C28887T"],"N":["T205I"],"nsp13":["L176F"],"nsp16":["T35I"]},"labels":{"aa":"N: T205I; nsp13: L176F; nsp16: T35I"}}},{"name":"B.1.350","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.350"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.350"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.54417610168457}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"B.1.349","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.349"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.349"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1025309562683105}},"branch_attrs":{"mutations":{"nuc":["C18555T","C28892T"],"N":["P207S"]},"labels":{"aa":"N: P207S"}}},{"name":"B.1.356","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.356"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.356"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.412571907043457}},"branch_attrs":{"mutations":{"nuc":["T13006C","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}}},{"name":"B.1.362","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.362"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.362"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.247318267822266}},"branch_attrs":{"mutations":{"nuc":["C683T","C6402T","T10249C","G11083T","G17427T","C28854T"],"N":["S194L"],"nsp3":["P1228L"],"nsp6":["L37F"]},"labels":{"aa":"N: S194L; nsp3: P1228L; nsp6: L37F"}}},{"name":"B.1.371","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.371"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.371"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.091424465179443}},"branch_attrs":{"mutations":{"nuc":["G29553A"]}}},{"name":"B.1.433","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.433"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.433"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.620072841644287}},"branch_attrs":{"mutations":{"nuc":["C6843T","T11764C","T17040C","C28887T","G29402T"],"N":["T205I","D377Y"],"nsp3":["S1375F"]},"labels":{"aa":"N: T205I, D377Y; nsp3: S1375F"}}},{"name":"B.1.428","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.428"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.428"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.0384840965271}},"branch_attrs":{"mutations":{"nuc":["C1302T"],"nsp2":["T166I"]},"labels":{"aa":"nsp2: T166I"}}},{"name":"B.1.453","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.453"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.453"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.12796688079834}},"branch_attrs":{"mutations":{"nuc":["C2668T"]}}},{"name":"B.1.566","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.566"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.566"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.346085548400879}},"branch_attrs":{"mutations":{"nuc":["C13860T"]}}},{"name":"B.1.570","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.570"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.570"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.377383708953857}},"branch_attrs":{"mutations":{"nuc":["T7767C","G11087A","C13452T","C21161T","C23604T","G25455T","T29867A","G29868A","C29870A"],"ORF3a":["K21N"],"S":["P681L"],"nsp11":["A4V"],"nsp12":["A4V"],"nsp16":["A168V"],"nsp3":["I1683T"],"nsp6":["E39K"]},"labels":{"aa":"ORF3a: K21N; S: P681L; nsp11: A4V; nsp12: A4V; nsp16: A168V; nsp3: I1683T; nsp6: E39K","spike_mutations":"P681L"}}},{"name":"B.1.576","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.576"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.576"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-2.8577709197998047}},"branch_attrs":{"mutations":{}}},{"name":"B.1.605","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.605"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.605"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C10747T","C13694T","T14103C","C24909A"],"S":["T1116N"],"nsp12":["T85I"]},"labels":{"aa":"S: T1116N; nsp12: T85I","spike_mutations":"T1116N"}}},{"name":"B.1.606","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.606"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.606"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.8544087409973145}},"branch_attrs":{"mutations":{"nuc":["C10015T","G14829T","C23191T","G26769T"],"M":["A83S"],"nsp12":["M463I"]},"labels":{"aa":"M: A83S; nsp12: M463I"}}},{"name":"NODE_0000495","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{"nuc":["C16260T","C28821A"],"N":["S183Y"]},"labels":{"aa":"N: S183Y"}},"children":[{"name":"B.1.369","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.369"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.369"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{"nuc":["A1C"]}}},{"name":"B.1.564","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.564"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.564"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000496","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.185941696166992}},"branch_attrs":{"mutations":{"nuc":["C10582T","C27804T","C28830A"],"N":["S186Y"]},"labels":{"aa":"N: S186Y"}},"children":[{"name":"B.1.367","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.367"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.367"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C3099T","G4960T","C4965T","C6070T","C7303T","C7564T","C9246T","C10279T","C10301A","C10525T","G10688T","G11851T","C14230A","G21800T","G27632T","G29402T","G29779T"],"N":["D377Y"],"ORF7a":["R80I"],"S":["D80Y"],"nsp12":["P264T"],"nsp3":["T127I","T749I"],"nsp4":["A231V"],"nsp5":["Q83K","V212F"],"nsp7":["M3I"]},"labels":{"aa":"N: D377Y; ORF7a: R80I; S: D80Y; nsp12: P264T; nsp3: T127I, T749I; nsp4: A231V; nsp5: Q83K, V212F; nsp7: M3I","spike_mutations":"D80Y"}}},{"name":"B.1.597","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.597"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.597"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.185941696166992}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000497","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.831107139587402}},"branch_attrs":{"mutations":{"nuc":["G17259T","C28887T"],"N":["T205I"],"nsp13":["E341D"]},"labels":{"aa":"N: T205I; nsp13: E341D"}},"children":[{"name":"B.1.375","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.375"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.375"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.301671028137207}},"branch_attrs":{"mutations":{"nuc":["T1171C","A5747G","C10789T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G24007A","C25844T","A26664G"],"M":["I48V"],"ORF3a":["T151I"],"S":["H69-","V70-"],"nsp3":["T1010A"]},"labels":{"aa":"M: I48V; ORF3a: T151I; S: H69-, V70-; nsp3: T1010A","spike_mutations":"H69-, V70-"}}},{"name":"B.1.596.1","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.596.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.596.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["C21780T","G25907T","G28857A"],"N":["R195K"],"ORF3a":["G172V"],"S":["T73I"]},"labels":{"aa":"N: R195K; ORF3a: G172V; S: T73I","spike_mutations":"T73I"}}}]},{"name":"NODE_0000498","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.184943199157715}},"branch_attrs":{"mutations":{"nuc":["A23064C"],"S":["N501T"]},"labels":{"aa":"S: N501T","spike_mutations":"N501T"}},"children":[{"name":"B.1.517","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.517"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.517"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8103365898132324}},"branch_attrs":{"mutations":{"nuc":["G3231T","A12850G","C21364T","C28890T"],"N":["S206F"],"nsp16":["P236S"],"nsp3":["G171V"]},"labels":{"aa":"N: S206F; nsp16: P236S; nsp3: G171V"}}},{"name":"B.1.626","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.626"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.626"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1914A","C2197T","C9142T","C9803T","C10416T","C10908T","G11222T","C13011T","C16961T","C21614T","C21758-","A21759-","T21760-","G21761-","C21762-","T21763-","A21764-","T21765-","A21766-","G22331A","G23012A","T23031C","C24138A","T24364C","C25511T","C25583T","T26767G","C27434T","A28271-","G28280T","C28887T","C29627T","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"M":["I82S"],"N":["D3Y","T205I"],"ORF10":["R24C"],"ORF3a":["S40L","T64I"],"ORF7a":["T14I"],"S":["L18F","H66-","A67-","I68-","G257S","E484K","F490S","T859N"],"nsp13":["P242L"],"nsp2":["R370H"],"nsp5":["S121L","A285V"],"nsp6":["V84F"],"nsp9":["T109I"]},"labels":{"aa":"M: I82S; N: D3Y, T205I; ORF10: R24C; ORF3a: S40L, T64I; ORF7a: T14I; S: L18F, H66-, A67-, I68-, G257S, E484K, F490S, T859N; nsp13: P242L; nsp2: R370H; nsp5: S121L, A285V; nsp6: V84F; nsp9: T109I","spike_mutations":"L18F, H66-, A67-, I68-, G257S, E484K, F490S, T859N"}}}]},{"name":"NODE_0000499","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.420584678649902}},"branch_attrs":{"mutations":{"nuc":["T9867C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C25517T","C27925T","A28271-"],"ORF3a":["P42L"],"ORF8":["T11I"],"nsp4":["L438P"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"ORF3a: P42L; ORF8: T11I; nsp4: L438P; nsp6: S106-, G107-, F108-"}},"children":[{"name":"B.1.526","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.526"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Iota"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21F (Iota)"},"partiallyAliased":{"value":"B.1.526"},"clade_nextstrain":{"value":"21F"},"clade_membership":{"value":"21F"},"placement_prior":{"value":-2.530679702758789}},"branch_attrs":{"mutations":{"nuc":["A16500C","A20262G","C21575T","C21846T","A22320G"],"S":["L5F","T95I","D253G"],"nsp13":["Q88H"]},"labels":{"aa":"S: L5F, T95I, D253G; nsp13: Q88H","clade":"Iota","spike_mutations":"L5F, T95I, D253G"}}},{"name":"B.1.637","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.637"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.637"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.0130152702331543}},"branch_attrs":{"mutations":{"nuc":["A9749G","C9891T","G11804A","A21801G","T21992-","A21993-","T21994-","T22032C","T22917G","C24138A","G24410C","G28044T","C28887T","G28975A"],"N":["T205I","M234I"],"ORF8":["A51S"],"S":["D80G","Y144-","F157S","L452R","T859N","D950H"],"nsp4":["K399E","A446V"],"nsp6":["V278I"]},"labels":{"aa":"N: T205I, M234I; ORF8: A51S; S: D80G, Y144-, F157S, L452R, T859N, D950H; nsp4: K399E, A446V; nsp6: V278I","spike_mutations":"D80G, Y144-, F157S, L452R, T859N, D950H"}}}]},{"name":"NODE_0000500","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.342108726501465}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28887T"],"N":["T205I"],"S":["L452R"]},"labels":{"aa":"N: T205I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"B.1.630","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.630"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.630"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C629T","A1262G","C1627T","G4963T","A5040G","A5648C","C6730T","C6794T","C7768T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T17505C","C19602T","G21255T","C21588T","C21637T","G21969T","T21992-","A21993-","T21994-","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22995G","G23012C","C23525T","G24410A","C25498-","C25499-","G25500-","A25501-","T25502-","A25503-","C25504-","A25505-","A25506-","G25507-","C25508-","C25509-","T25510-","C25511-","A25512-","C25513-","T25514-","C25515-","C25516-","C25517-","T25518-","T25519-","T25520-","C25521-","T25563G","T27796C","C27889T","A28272G","C28512G","G29508A","C29739T"],"N":["P80R","S412N"],"ORF3a":["P36-","I37-","Q38-","A39-","S40-","L41-","P42-","F43-","H57Q"],"ORF7b":["L14S"],"ORF9b":["Q77E"],"S":["P9L","C136F","Y144-","A222V","L242-","A243-","T478R","E484Q","H655Y","D950N"],"nsp1":["L122F"],"nsp2":["T153A"],"nsp3":["R748S","Q774R","K977Q"],"nsp4":["A446V"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P80R, S412N; ORF3a: P36-, I37-, Q38-, A39-, S40-, L41-, P42-, F43-, H57Q; ORF7b: L14S; ORF9b: Q77E; S: P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N; nsp1: L122F; nsp2: T153A; nsp3: R748S, Q774R, K977Q; nsp4: A446V; nsp6: S106-, G107-, F108-","spike_mutations":"P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N"}}},{"name":"21C","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Epsilon"},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["G17014T","G21600T","G22018T","C26681T","A28272T"],"S":["S13I","W152C"],"nsp13":["D260Y"]},"labels":{"aa":"S: S13I, W152C; nsp13: D260Y","clade":"Epsilon","spike_mutations":"S13I, W152C"}},"children":[{"name":"B.1.429","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.429"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Epsilon"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1.429"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-2.493906021118164}},"branch_attrs":{"mutations":{"nuc":["C2395T","T2597C","C8947T","C12100T","A12878G","T24349C","G27890T"],"nsp9":["I65V"]},"labels":{"aa":"nsp9: I65V"}}},{"name":"B.1.427","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.427"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Epsilon"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1.427"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-2.8388147354125977}},"branch_attrs":{"mutations":{"nuc":["G9738C","G13713A","C16394T","C29362T"],"nsp13":["P53L"],"nsp4":["S395T"]},"labels":{"aa":"nsp13: P53L; nsp4: S395T"}}}]}]},{"name":"NODE_0000502","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.435559272766113}},"branch_attrs":{"mutations":{"nuc":["C6730T","T23042C","C23604A"],"S":["S494P","P681H"]},"labels":{"aa":"S: S494P, P681H","spike_mutations":"S494P, P681H"}},"children":[{"name":"B.1.623","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.623"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["T8704C","C9120T","C9870T","C11005A","C12854T","C13458T","G14559A","A23063T","G24893A","A27926-","A27927-","C27928-","T27929-","G27930-","T27931-","A27932-","G27933-","C27934-","T27935-","G27936-","C27937-","A27938-","T27939-","T27940-","T27941-","C27942-","A27943-","C27944-","C27945-","A27946-","A27947-","G27948-","A27949-","A27950-","T27951-","G27952-","T27953-","A27954-","G27955-","A28272T","G28975A"],"N":["M234I"],"ORF8":["T12-","V13-","A14-","A15-","F16-","H17-","Q18-","E19-","C20-","S21-"],"S":["N501Y","E1111K"],"nsp11":["S6L"],"nsp12":["S6L"],"nsp4":["T189I","T439M"],"nsp6":["H11Q"],"nsp9":["P57S"]},"labels":{"aa":"N: M234I; ORF8: T12-, V13-, A14-, A15-, F16-, H17-, Q18-, E19-, C20-, S21-; S: N501Y, E1111K; nsp11: S6L; nsp12: S6L; nsp4: T189I, T439M; nsp6: H11Q; nsp9: P57S","spike_mutations":"N501Y, E1111K"}}},{"name":"NODE_0000503","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.575"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8313353061676025}},"branch_attrs":{"mutations":{"nuc":["A1C","A1180G","C6936T","C10029T","C11514T","C16375T","T20748C","C23709T","T26767C","A28271-","C28887T","G29711-","C29719T"],"M":["I82T"],"N":["T205I"],"S":["T716I"],"nsp13":["P47S"],"nsp3":["S1406F"],"nsp4":["T492I"],"nsp6":["T181I"]},"labels":{"aa":"M: I82T; N: T205I; S: T716I; nsp13: P47S; nsp3: S1406F; nsp4: T492I; nsp6: T181I","spike_mutations":"T716I"}},"children":[{"name":"B.1.575","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.575"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8313353061676025}},"branch_attrs":{"mutations":{}}},{"name":"B.1.575.1","node_attrs":{"div":22,"Nextclade_pango":{"value":"B.1.575.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.6448798179626465}},"branch_attrs":{"mutations":{"nuc":["G29513T","C29614T"],"N":["A414S"]},"labels":{"aa":"N: A414S"}}}]}]},{"name":"NODE_0000504","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.8868496417999268}},"branch_attrs":{"mutations":{"nuc":["G174T","G5230T","A10323G","A21801C","A22206G","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","G22813T","G23012A","A23063T","C23664T","C26456T","C28253T","C28887T"],"E":["P71L"],"N":["T205I"],"S":["D80A","D215G","L241-","L242-","A243-","K417N","E484K","N501Y","A701V"],"nsp3":["K837N"],"nsp5":["K90R"]},"labels":{"aa":"E: P71L; N: T205I; S: D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V; nsp3: K837N; nsp5: K90R","clade":"Beta","spike_mutations":"D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V"}},"children":[{"name":"B.1.351.1","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.351.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.1"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-5.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["C11289G","G11291T","G11292A","T11293C","G11299T","C11300T","T11301A","A11302C","C22513A"],"S":["N317K"],"nsp6":["S106C","G107Y","K109N","L110Y"]},"labels":{"aa":"S: N317K; nsp6: S106C, G107Y, K109N, L110Y","spike_mutations":"N317K"}}},{"name":"NODE_0000505","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.2380783557891846}},"branch_attrs":{"mutations":{"nuc":["C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}},"children":[{"name":"B.1.351","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.351"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.2380783557891846}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-2.969865322113037}},"branch_attrs":{"mutations":{"nuc":["A2692T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C21614T"],"S":["L18F"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"S: L18F; nsp6: S106-, G107-, F108-","spike_mutations":"L18F"}},"children":[{"name":"B.1.351.5","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.351.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.5"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-4.056199073791504}},"branch_attrs":{"mutations":{"nuc":["C664T","G1463T","C16338T","C19019A","C24109T","C24334T","G25660A","C25844T","C26645T","A29406T"],"N":["E378V"],"ORF3a":["V90I","T151I"],"nsp14":["P327Q"],"nsp2":["G220C"]},"labels":{"aa":"N: E378V; ORF3a: V90I, T151I; nsp14: P327Q; nsp2: G220C"}}},{"name":"NODE_0000507","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A8052G","G10396T"],"nsp3":["N1778S"]},"labels":{"aa":"nsp3: N1778S"}},"children":[{"name":"B.1.351.2","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.351.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.2"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C10632T"],"nsp5":["A193V"]},"labels":{"aa":"nsp5: A193V"}}},{"name":"B.1.351.3","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.351.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.3"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-4.018410682678223}},"branch_attrs":{"mutations":{"nuc":["T3G","C6402T","T7624C","C10615T","A16687G"],"nsp13":["I151V"],"nsp3":["P1228L"]},"labels":{"aa":"nsp13: I151V; nsp3: P1228L"}}}]}]}]}]},{"name":"NODE_0000508","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.577651023864746}},"branch_attrs":{"mutations":{"nuc":["A10323G","G28842T"],"N":["S190I"],"nsp5":["K90R"]},"labels":{"aa":"N: S190I; nsp5: K90R"}},"children":[{"name":"B.1.361","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.361"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.361"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.086843013763428}},"branch_attrs":{"mutations":{"nuc":["A705G","G1463A","G11417T","C18167T","A21080G","G29779T"],"nsp1":["D147G"],"nsp14":["P43L"],"nsp16":["K141R"],"nsp2":["G220S"],"nsp6":["V149F"]},"labels":{"aa":"nsp1: D147G; nsp14: P43L; nsp16: K141R; nsp2: G220S; nsp6: V149F"}}},{"name":"B.1.580","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.580"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.580"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.577651023864746}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000509","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{"nuc":["T15276A"]}},"children":[{"name":"B.1.568","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.568"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.568"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.0975661277771}},"branch_attrs":{"mutations":{"nuc":["C5654T","C10450T","C12049T","C12455A","C16428T","C17483T","G25913A","G27916T"],"ORF3a":["G174D"],"ORF8":["G8V"],"nsp13":["T416I"],"nsp8":["L122I"]},"labels":{"aa":"ORF3a: G174D; ORF8: G8V; nsp13: T416I; nsp8: L122I"}}},{"name":"B.1.582","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.582"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.582"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{}}},{"name":"B.1.612","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.612"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.612"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000510","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.043567180633545}},"branch_attrs":{"mutations":{"nuc":["C11916T"],"nsp7":["S25L"]},"labels":{"aa":"nsp7: S25L"}},"children":[{"name":"B.1.3","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.3"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C715T","A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"B.1.497","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.497"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.497"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A1G","C16650T","A20675T","G29179T"],"nsp16":["Q6L"]},"labels":{"aa":"nsp16: Q6L"}}},{"name":"B.1.509","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.509"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.509"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.097189426422119}},"branch_attrs":{"mutations":{"nuc":["C1385T","G1738T","G3242A","C28087T"],"ORF8":["A65V"],"nsp2":["H194Y"],"nsp3":["G175S"]},"labels":{"aa":"ORF8: A65V; nsp2: H194Y; nsp3: G175S"}}},{"name":"NODE_0000511","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8577680587768555}},"branch_attrs":{"mutations":{"nuc":["C18998T","G29540A"],"nsp14":["A320V"]},"labels":{"aa":"nsp14: A320V"}},"children":[{"name":"B.1.499","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.499"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.499"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["C28863T"],"N":["S197L"]},"labels":{"aa":"N: S197L"}}},{"name":"B.1.503","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.503"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.503"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25947C"],"ORF3a":["Q185H"]},"labels":{"aa":"ORF3a: Q185H"}}},{"name":"B.1.505","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.505"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.505"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C66A","C7768T","A8773G","C17304T","T24805C"]}}}]}]},{"name":"NODE_0000512","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.3401401042938232}},"branch_attrs":{"mutations":{"nuc":["C27964T"],"ORF8":["S24L"]},"labels":{"aa":"ORF8: S24L"}},"children":[{"name":"B.1.265","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.265"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.265"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.231685638427734}},"branch_attrs":{"mutations":{"nuc":["C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}}},{"name":"B.1.336","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.336"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.336"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.561881065368652}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}}},{"name":"B.1.426","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.426"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.426"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8296751976013184}},"branch_attrs":{"mutations":{"nuc":["T833C","A22320G"],"S":["D253G"],"nsp2":["F10L"]},"labels":{"aa":"S: D253G; nsp2: F10L","spike_mutations":"D253G"}}},{"name":"NODE_0000513","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.462985992431641}},"branch_attrs":{"mutations":{"nuc":["A18424G","G25907T"],"ORF3a":["G172V"],"nsp14":["N129D"]},"labels":{"aa":"ORF3a: G172V; nsp14: N129D"}},"children":[{"name":"B.1.2","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20G"},"partiallyAliased":{"value":"B.1.2"},"clade_nextstrain":{"value":"20G"},"clade_membership":{"value":"20G"},"placement_prior":{"value":-2.0290451049804688}},"branch_attrs":{"mutations":{"nuc":["C10319T","C21304T","C28472T","C28869T"],"N":["P67S","P199L"],"nsp16":["R216C"],"nsp5":["L89F"]},"labels":{"aa":"N: P67S, P199L; nsp16: R216C; nsp5: L89F","clade":"20G"}}},{"name":"B.1.596","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.596"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.596"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.462985992431641}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000514","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7341673374176025}},"branch_attrs":{"mutations":{"nuc":["C10319T"],"nsp5":["L89F"]},"labels":{"aa":"nsp5: L89F"}},"children":[{"name":"B.1.567","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.567"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.567"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.657742500305176}},"branch_attrs":{"mutations":{"nuc":["C11575T","A20262G","G21305A","C28868T"],"N":["P199S"],"nsp16":["R216H"]},"labels":{"aa":"N: P199S; nsp16: R216H"}}},{"name":"B.1.577","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.577"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8689005374908447}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"nsp13":["T153I"]},"labels":{"aa":"nsp13: T153I"}}},{"name":"B.1.595","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.595"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.595"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7341673374176025}},"branch_attrs":{"mutations":{"nuc":["A1G"]}}},{"name":"NODE_0000515","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.714270114898682}},"branch_attrs":{"mutations":{"nuc":["G6052A","G19872T","G25855T","G29254T","G29474T"],"N":["D401Y"],"ORF3a":["D155Y"]},"labels":{"aa":"N: D401Y; ORF3a: D155Y"}},"children":[{"name":"B.1.587","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.587"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.587"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.290242671966553}},"branch_attrs":{"mutations":{"nuc":["T5122C","G20102T","C20117T","A22095G"],"S":["D178G"],"nsp15":["S161I","T166I"]},"labels":{"aa":"S: D178G; nsp15: S161I, T166I","spike_mutations":"D178G"}}},{"name":"B.1.588","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.588"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{"nuc":["C7600T","G7675C","C21621T","G22201T","G28975T","G29764T"],"N":["M234I"],"S":["T20I"]},"labels":{"aa":"N: M234I; S: T20I","spike_mutations":"T20I"}}}]}]}]}]},{"name":"NODE_0000516","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.617"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.895909309387207}},"branch_attrs":{"mutations":{"nuc":["G210T","T22917G","C23604G","T27638C","G28881T","G29402T","G29742T"],"N":["R203M","D377Y"],"ORF7a":["V82A"],"S":["T19R","L452R","P681R"]},"labels":{"aa":"N: R203M, D377Y; ORF7a: V82A; S: T19R, L452R, P681R","spike_mutations":"T19R, L452R, P681R"}},"children":[{"name":"B.1.617.3","node_attrs":{"div":22,"Nextclade_pango":{"value":"B.1.617.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C835T","C7296T","C8208T","G10634T","C11322T","C16293T","C21618G","G23012C","T27384C","C27970T","C28472T"],"N":["P67S"],"ORF8":["T26I"],"S":["E484Q"],"nsp3":["A1526V","T1830I"],"nsp5":["A194S"],"nsp6":["A117V"]},"labels":{"aa":"N: P67S; ORF8: T26I; S: E484Q; nsp3: A1526V, T1830I; nsp5: A194S; nsp6: A117V","spike_mutations":"E484Q"}}},{"name":"internal_d736","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.617"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.2567901611328125}},"branch_attrs":{"mutations":{"nuc":["G21987A","C25469T"],"ORF3a":["S26L"],"S":["G142D"]},"labels":{"aa":"ORF3a: S26L; S: G142D","spike_mutations":"G142D"}},"children":[{"name":"B.1.617.1","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.617.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Kappa"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21B (Kappa)"},"partiallyAliased":{"value":"B.1.617.1"},"clade_nextstrain":{"value":"21B"},"clade_membership":{"value":"21B"},"placement_prior":{"value":-3.281346321105957}},"branch_attrs":{"mutations":{"nuc":["C3457T","C4965T","A11201G","G17523T","A20396G","T21895C","G22022A","G23012C","C26681T","T26767G"],"M":["I82S"],"S":["R19T","E154K","E484Q"],"nsp13":["M429I"],"nsp15":["K259R"],"nsp3":["T749I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82S; S: R19T, E154K, E484Q; nsp13: M429I; nsp15: K259R; nsp3: T749I; nsp6: T77A","clade":"Kappa","spike_mutations":"R19T, E154K, E484Q"}}},{"name":"NODE_0000518","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.928345203399658}},"branch_attrs":{"mutations":{"nuc":["C21618G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22995A","G24410A","T26767C","C27752T","A28271-","A28461G"],"M":["I82T"],"N":["D63G"],"ORF7a":["T120I"],"ORF9b":["T60A"],"S":["E156-","F157-","R158G","T478K","D950N"]},"labels":{"aa":"M: I82T; N: D63G; ORF7a: T120I; ORF9b: T60A; S: E156-, F157-, R158G, T478K, D950N","clade":"Delta","spike_mutations":"E156-, F157-, R158G, T478K, D950N"}},"children":[{"name":"NODE_0000519","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.125234365463257}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","C5184T","G9203A","T9678C","C11005A","A17496G","A20396G","A21792C","C28253T"],"S":["K77T"],"nsp15":["K259R"],"nsp2":["P129L"],"nsp3":["P822L"],"nsp4":["D217N","F375S"],"nsp6":["H11Q"]},"labels":{"aa":"S: K77T; nsp15: K259R; nsp2: P129L; nsp3: P822L; nsp4: D217N, F375S; nsp6: H11Q","spike_mutations":"K77T"}},"children":[{"name":"AY.35","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.35"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.42242431640625}},"branch_attrs":{"mutations":{"nuc":["A1C","C6027A","C13989T","C16915T","G23012C"],"S":["E484Q"],"nsp3":["P1103Q"]},"labels":{"aa":"S: E484Q; nsp3: P1103Q","spike_mutations":"E484Q"}}},{"name":"AY.48","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.48"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.48"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A10399G","C10868T","G27948T"],"ORF8":["E19*"]},"labels":{"aa":"ORF8: E19*"}}}]},{"name":"NODE_0000520","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.281507730484009}},"branch_attrs":{"mutations":{"nuc":["G15451A","C16466T"],"nsp12":["G671S"],"nsp13":["P77L"]},"labels":{"aa":"nsp12: G671S; nsp13: P77L"}},"children":[{"name":"B.1.617.2","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.617.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.281507730484009}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000521","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.9130396842956543}},"branch_attrs":{"mutations":{"nuc":["C5184T","C9891T","T11418C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-"],"ORF8":["D119-","F120-"],"nsp3":["P822L"],"nsp4":["A446V"],"nsp6":["V149A"]},"labels":{"aa":"ORF8: D119-, F120-; nsp3: P822L; nsp4: A446V; nsp6: V149A"}},"children":[{"name":"NODE_0000522","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.995262622833252}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","T12946C","A20262G","C27739T"],"ORF7a":["L116F"],"nsp2":["P129L"]},"labels":{"aa":"ORF7a: L116F; nsp2: P129L"}},"children":[{"name":"NODE_0000523","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.093592882156372}},"branch_attrs":{"mutations":{"nuc":["C6539T","C20320T","C24745T","G28690T","G29427A"],"N":["L139F","R385K"],"nsp15":["H234Y"],"nsp3":["H1274Y"]},"labels":{"aa":"N: L139F, R385K; nsp15: H234Y; nsp3: H1274Y"}},"children":[{"name":"AY.30","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.30"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.30"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.6562893390655518}},"branch_attrs":{"mutations":{"nuc":["C9319T","A13482G","-28271A","G29781T"]}}},{"name":"AY.40","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.40"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.40"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["A1558G","C1912T","G2755T","A15892G","G23282T","C28099T","T28297C"],"ORF8":["S69L"],"ORF9b":["I5T"],"S":["D574Y"],"nsp12":["M818V"],"nsp2":["I251M"]},"labels":{"aa":"ORF8: S69L; ORF9b: I5T; S: D574Y; nsp12: M818V; nsp2: I251M","spike_mutations":"D574Y"}}}]},{"name":"NODE_0000524","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.395604133605957}},"branch_attrs":{"mutations":{"nuc":["C18176T"],"nsp14":["P46L"]},"labels":{"aa":"nsp14: P46L"}},"children":[{"name":"AY.49","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.49"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF3a:30-276"},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.frameShifts":{"value":"ORF3a:30-276"},"qc.frameShifts.totalFrameShifts":{"value":1},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.49"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T5773C","C10834T","C23039G","G24124T","G25471-","A25472-","T25473-","T25474-","T25475-","T25476-","G25477-","T25478-","C26110T","A27979T"],"ORF3a":["L26-","D27-","F28-","V29-"],"ORF8":["Q29L"],"S":["Q493E","K854N"]},"labels":{"aa":"ORF3a: L26-, D27-, F28-, V29-; ORF8: Q29L; S: Q493E, K854N","spike_mutations":"Q493E, K854N"}}},{"name":"AY.50","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.50"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.50"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C884T","C5730T","C19554T","G22484C","-28271A","G28809T"],"N":["G179V"],"S":["V308L"],"nsp2":["R27C"],"nsp3":["T1004I"]},"labels":{"aa":"N: G179V; S: V308L; nsp2: R27C; nsp3: T1004I","spike_mutations":"V308L"}}},{"name":"AY.53","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.53"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.53"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.5879409313201904}},"branch_attrs":{"mutations":{"nuc":["G1738T","A2292C","C18348T","C20031T","G21641T"],"S":["A27S"],"nsp2":["Q496P"]},"labels":{"aa":"S: A27S; nsp2: Q496P","spike_mutations":"A27S"}}},{"name":"AY.52","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.52"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.52"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["T24984G","T25689C","G26428T","C26858T","C28419T"],"E":["V62F"],"N":["T49I"],"S":["L1141W"]},"labels":{"aa":"E: V62F; N: T49I; S: L1141W","spike_mutations":"L1141W"}}},{"name":"AY.8","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.8"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.8487331867218018}},"branch_attrs":{"mutations":{"nuc":["C11455T","A14170G"],"nsp12":["I244V"]},"labels":{"aa":"nsp12: I244V"}}},{"name":"NODE_0000525","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.849754571914673}},"branch_attrs":{"mutations":{"nuc":["A18468G"]}},"children":[{"name":"AY.13","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.13"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.3170342445373535}},"branch_attrs":{"mutations":{"nuc":["A17406G","C29095T"]}}},{"name":"NODE_0000526","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.16"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{"nuc":["T26076A"]}},"children":[{"name":"AY.16.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16.1"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C8407T","A12417G","G12911A","C14913T","T29867A"],"nsp8":["N109S"],"nsp9":["V76I"]},"labels":{"aa":"nsp8: N109S; nsp9: V76I"}}},{"name":"AY.16","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000527","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.429879188537598}},"branch_attrs":{"mutations":{"nuc":["C19160T"],"nsp14":["S374F"]},"labels":{"aa":"nsp14: S374F"}},"children":[{"name":"AY.14","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.14"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.0154049396514893}},"branch_attrs":{"mutations":{"nuc":["T1877G","G20718T"],"nsp16":["M20I"],"nsp2":["S358A"]},"labels":{"aa":"nsp16: M20I; nsp2: S358A"}}},{"name":"AY.15","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.15"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.385550022125244}},"branch_attrs":{"mutations":{"nuc":["A16872G","G27382C","-28271A"],"ORF6":["D61H"]},"labels":{"aa":"ORF6: D61H"}}},{"name":"AY.54","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.54"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.54"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.0774950981140137}},"branch_attrs":{"mutations":{"nuc":["A1G","C193T","G14187A","A25806G"]}}}]},{"name":"NODE_0000528","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.0211334228515625}},"branch_attrs":{"mutations":{"nuc":["A25562G"],"ORF3a":["Q57R"]},"labels":{"aa":"ORF3a: Q57R"}},"children":[{"name":"AY.19","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.19"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.19"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25019T","G25947T","-28271A"],"ORF3a":["Q185H"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: Q185H; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"AY.17","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.17"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2240G","C14708T","C17436T","-28271A"],"nsp12":["A423V"],"nsp2":["I479V"]},"labels":{"aa":"nsp12: A423V; nsp2: I479V"}}},{"name":"AY.51","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.51"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.51"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.137358665466309}},"branch_attrs":{"mutations":{"nuc":["G12223T","A25697T"],"ORF3a":["E102V"]},"labels":{"aa":"ORF3a: E102V"}}}]}]}]},{"name":"NODE_0000529","node_attrs":{"div":26,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6166188716888428}},"branch_attrs":{"mutations":{"nuc":["C11514T","C22227T"],"S":["A222V"],"nsp6":["T181I"]},"labels":{"aa":"S: A222V; nsp6: T181I","clade":"21I","spike_mutations":"A222V"}},"children":[{"name":"AY.62","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.62"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.62"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["A1045T","G1820A","A20085G","C28093T","G29440A"],"ORF8":["S67F"],"nsp2":["G339S"]},"labels":{"aa":"ORF8: S67F; nsp2: G339S"}}},{"name":"NODE_0000530","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6697630882263184}},"branch_attrs":{"mutations":{"nuc":["A5584G"]}},"children":[{"name":"AY.24","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.24"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.24"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.5928659439086914}},"branch_attrs":{"mutations":{"nuc":["C23896T","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"NODE_0000531","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.90034556388855}},"branch_attrs":{"mutations":{"nuc":["C13019T"]}},"children":[{"name":"AY.10","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.10"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.07296895980835}},"branch_attrs":{"mutations":{"nuc":["G219T","A8651G","G9526T","C12756T","C13665T","A23734G"],"nsp4":["M33V","M324I"],"nsp9":["T24I"]},"labels":{"aa":"nsp4: M33V, M324I; nsp9: T24I"}}},{"name":"AY.11","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.11"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.418825149536133}},"branch_attrs":{"mutations":{"nuc":["C3486T","C18526T","T19516C","G26526T","C29509T"],"M":["A2S"],"nsp14":["R163C"],"nsp3":["A256V"]},"labels":{"aa":"M: A2S; nsp14: R163C; nsp3: A256V"}}},{"name":"AY.28","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.28"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.28"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C335T","G2167T","C8950T","C9246T","G23663T","G24794T","G25855T"],"ORF3a":["D155Y"],"S":["A701S","A1078S"],"nsp1":["R24C"],"nsp2":["K454N"],"nsp4":["A231V"]},"labels":{"aa":"ORF3a: D155Y; S: A701S, A1078S; nsp1: R24C; nsp2: K454N; nsp4: A231V","spike_mutations":"A701S, A1078S"}}},{"name":"AY.27","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.27"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.27"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.8427717685699463}},"branch_attrs":{"mutations":{"nuc":["T11938C","A14475G","G29422T"]}}},{"name":"AY.47","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.47"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.47"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.620307445526123}},"branch_attrs":{"mutations":{"nuc":["C1684T","G5164T","C12049T","G22427A","G28326T"],"N":["G18V"],"ORF9b":["V15L"],"S":["V289I"],"nsp3":["E815D"]},"labels":{"aa":"N: G18V; ORF9b: V15L; S: V289I; nsp3: E815D","spike_mutations":"V289I"}}},{"name":"AY.55","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.55"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.55"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.71439266204834}},"branch_attrs":{"mutations":{"nuc":["A10978G","-28271A"]}}},{"name":"AY.57","node_attrs":{"div":30,"Nextclade_pango":{"value":"AY.57"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.57"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.764986515045166}},"branch_attrs":{"mutations":{"nuc":["C1403T","G5584T"],"nsp2":["P200S"]},"labels":{"aa":"nsp2: P200S"}}},{"name":"AY.56","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.56"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.56"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3634T","C25624T","G27870T"],"ORF3a":["H78Y"],"ORF7b":["E39*"]},"labels":{"aa":"ORF3a: H78Y; ORF7b: E39*"}}},{"name":"AY.59","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.59"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.59"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C19164T","T20391G","C21302T"],"nsp16":["P215L"]},"labels":{"aa":"nsp16: P215L"}}},{"name":"AY.61","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.61"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.61"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.942255735397339}},"branch_attrs":{"mutations":{"nuc":["T25532C"],"ORF3a":["I47T"]},"labels":{"aa":"ORF3a: I47T"}}},{"name":"AY.60","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.60"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.60"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A2165C","C2919T","G4162T","T8634C","T12056A","T13701C","G17122T"],"nsp13":["A296S"],"nsp2":["K454Q"],"nsp3":["P67L"],"nsp4":["I27T"],"nsp7":["C72S"]},"labels":{"aa":"nsp13: A296S; nsp2: K454Q; nsp3: P67L; nsp4: I27T; nsp7: C72S"}}},{"name":"AY.64","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.64"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.64"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.9437766075134277}},"branch_attrs":{"mutations":{"nuc":["T2C","C346T","C5784T","C6388T","C24130T","G25135T","G25691T","C27005T","G29254T","G29688T"],"ORF3a":["G100V"],"S":["K1191N"],"nsp3":["T1022I"]},"labels":{"aa":"ORF3a: G100V; S: K1191N; nsp3: T1022I","spike_mutations":"K1191N"}}},{"name":"AY.68","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.68"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.68"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.760132312774658}},"branch_attrs":{"mutations":{"nuc":["G105T","C3294T","C8208T","C14362T","C19524T","A22320C","T24499A","C25782T","A26891G","T27878C"],"S":["D253A","D979E"],"nsp3":["P192L","T1830I"]},"labels":{"aa":"S: D253A, D979E; nsp3: P192L, T1830I","spike_mutations":"D253A, D979E"}}},{"name":"AY.67","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.67"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.67"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8576669692993164}},"branch_attrs":{"mutations":{"nuc":["C4890T","T5644C","T19519C","A27368G"],"ORF6":["Q56R"],"nsp14":["Y494H"],"nsp3":["T724I"]},"labels":{"aa":"ORF6: Q56R; nsp14: Y494H; nsp3: T724I"}}},{"name":"AY.66","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.66"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.66"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T13C","T6496C","G14874T","C28892T"],"N":["P207S"],"nsp12":["K478N"]},"labels":{"aa":"N: P207S; nsp12: K478N"}}},{"name":"AY.69","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.69"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.69"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C3984T","A4405T","A4838G","G9431A","G16864A","G17847A","G25720T","C27559T"],"ORF3a":["A110S"],"nsp13":["V210I"],"nsp3":["T422I","I707V"],"nsp4":["V293I"]},"labels":{"aa":"ORF3a: A110S; nsp13: V210I; nsp3: T422I, I707V; nsp4: V293I"}}},{"name":"AY.70","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.70"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.70"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.4444901943206787}},"branch_attrs":{"mutations":{"nuc":["C4891T","G21255T","G21624C","G28899T","G28903T"],"N":["R209I","M210I"],"S":["R21T"]},"labels":{"aa":"N: R209I, M210I; S: R21T","spike_mutations":"R21T"}}},{"name":"NODE_0000532","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.80359411239624}},"branch_attrs":{"mutations":{"nuc":["C5192T"]}},"children":[{"name":"AY.58","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.58"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.58"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["G8540A","C26079A","C27131T"],"nsp3":["A1941T"]},"labels":{"aa":"nsp3: A1941T"}}},{"name":"AY.63","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.63"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.63"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.740610122680664}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","A7886G","C8964T","C9857T","C13335T","A14246G","A19126G","A23848G","C25710T","G29616T","T29728C"],"ORF10":["R20I"],"nsp1":["K141-","S142-","F143-"],"nsp10":["A104V"],"nsp12":["D269G"],"nsp14":["I363V"],"nsp3":["I1723V"],"nsp4":["S137L"]},"labels":{"aa":"ORF10: R20I; nsp1: K141-, S142-, F143-; nsp10: A104V; nsp12: D269G; nsp14: I363V; nsp3: I1723V; nsp4: S137L"}}}]},{"name":"NODE_0000533","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.75"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1813862323760986}},"branch_attrs":{"mutations":{"nuc":["C21622T"]}},"children":[{"name":"AY.75","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.75"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1813862323760986}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000534","node_attrs":{"div":30,"Nextclade_pango":{"value":"AY.75"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.644587278366089}},"branch_attrs":{"mutations":{"nuc":["G29744A"]}},"children":[{"name":"AY.75.2","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.75.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T13C","T7717C","A16824G","A21987G","G23611T"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}}},{"name":"AY.75.3","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.75.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75.3"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T322C","C1329A","G8428A","G16873A","T19127C","C22314T"],"S":["P251L"],"nsp13":["G213S"],"nsp14":["I363T"],"nsp2":["T175N"]},"labels":{"aa":"S: P251L; nsp13: G213S; nsp14: I363T; nsp2: T175N","spike_mutations":"P251L"}}}]}]},{"name":"NODE_0000535","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.9"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.33573317527771}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"AY.9","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.33573317527771}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000536","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.9.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.80546498298645}},"branch_attrs":{"mutations":{"nuc":["G1729A","G14030A","C18086T"],"nsp12":["R197Q"],"nsp14":["T16I"]},"labels":{"aa":"nsp12: R197Q; nsp14: T16I"}},"children":[{"name":"AY.9.2.2","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.9.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6840121746063232}},"branch_attrs":{"mutations":{"nuc":["C4321T","A9685G","C23585A"],"S":["Q675K"],"nsp4":["I377M"]},"labels":{"aa":"S: Q675K; nsp4: I377M","spike_mutations":"Q675K"}}},{"name":"AY.9.2","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.80546498298645}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000537","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.977773427963257}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.133","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.133"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C203T","C449T","C4763T","C12025T","C20104T","T21613A","C21614T","C23058G","C24370T","T25333C","T29867A"],"S":["N17K","L18F","P499R"],"nsp1":["P62S"],"nsp15":["L162F"],"nsp3":["H682Y"]},"labels":{"aa":"S: N17K, L18F, P499R; nsp1: P62S; nsp15: L162F; nsp3: H682Y","spike_mutations":"N17K, L18F, P499R"}}},{"name":"NODE_0000538","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T13019C"]}},"children":[{"name":"AY.65","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.65"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:121-122"},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.65"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G14028T","C27005T","-28253T","-28271A"],"nsp12":["M196I"]},"labels":{"aa":"nsp12: M196I"}}},{"name":"NODE_0000539","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.26"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.016456365585327}},"branch_attrs":{"mutations":{"nuc":["A27345T"],"ORF6":["K48N"]},"labels":{"aa":"ORF6: K48N"}},"children":[{"name":"AY.26","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.26"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.016456365585327}},"branch_attrs":{"mutations":{}}},{"name":"AY.26.1","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26.1"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G20580T","A21987G","G23012C","A24587T","G26529C","G27703T","C29769T"],"M":["D3H"],"ORF7a":["V104F"],"S":["D142G","E484Q","T1009S"]},"labels":{"aa":"M: D3H; ORF7a: V104F; S: D142G, E484Q, T1009S","spike_mutations":"D142G, E484Q, T1009S"}}}]}]}]},{"name":"NODE_0000540","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1191558837890625}},"branch_attrs":{"mutations":{"nuc":["C2509T"]}},"children":[{"name":"AY.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6743457317352295}},"branch_attrs":{"mutations":{"nuc":["A1G","T3055C","G3701A","C17336T","C18570T","G21770T","G22813T","T29867A","G29868A"],"S":["V70F","K417N"],"nsp13":["T367I"],"nsp3":["A328T"]},"labels":{"aa":"S: V70F, K417N; nsp13: T367I; nsp3: A328T","spike_mutations":"V70F, K417N"}}},{"name":"AY.37","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.37"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.37"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6478559970855713}},"branch_attrs":{"mutations":{"nuc":["G2185T","T20911C"],"nsp2":["E460D"]},"labels":{"aa":"nsp2: E460D"}}},{"name":"AY.38","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.38"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.963697910308838}},"branch_attrs":{"mutations":{"nuc":["G15760T","A22310T","-28271A","G29212T","T29742G"],"S":["T250S"],"nsp12":["G774C"]},"labels":{"aa":"S: T250S; nsp12: G774C","spike_mutations":"T250S"}}},{"name":"AY.71","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.71"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.71"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8321352005004883}},"branch_attrs":{"mutations":{"nuc":["A1T","C25317T","-28271A"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"NODE_0000541","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.954825401306152}},"branch_attrs":{"mutations":{"nuc":["G5539A"]}},"children":[{"name":"AY.73","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.73"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.73"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.9488861560821533}},"branch_attrs":{"mutations":{"nuc":["C222T","C6573T","C27657T","C28409T","C28893T"],"N":["P46S","P207L"],"nsp3":["S1285F"]},"labels":{"aa":"N: P46S, P207L; nsp3: S1285F"}}},{"name":"AY.72","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.72"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.72"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.11883020401001}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G6080T","A25856G","C26013T"],"ORF3a":["D155G"],"nsp1":["K141-","S142-","F143-"],"nsp3":["D1121Y"]},"labels":{"aa":"ORF3a: D155G; nsp1: K141-, S142-, F143-; nsp3: D1121Y"}}},{"name":"AY.74","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.74"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.74"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1409428119659424}},"branch_attrs":{"mutations":{"nuc":["G3994A","C25413T","G29392T"],"N":["K373N"]},"labels":{"aa":"N: K373N"}}}]}]}]}]}]}]},{"name":"NODE_0000542","node_attrs":{"div":32,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1918766498565674}},"branch_attrs":{"mutations":{"nuc":["G4181T","C6402T","C7124T","C8986T","C10029T","A11201G","A11332G","C19220T","C21846T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","G28916T"],"N":["G215C"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"S":["T95I"],"nsp14":["A394V"],"nsp3":["A488S","P1228L","P1469S"],"nsp4":["T492I"],"nsp6":["T77A"]},"labels":{"aa":"N: G215C; ORF7b: T40I; ORF8: D119-, F120-; S: T95I; nsp14: A394V; nsp3: A488S, P1228L, P1469S; nsp4: T492I; nsp6: T77A","clade":"21J","spike_mutations":"T95I"}},"children":[{"name":"AY.78","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.78"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.78"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.552331924438477}},"branch_attrs":{"mutations":{"nuc":["T13188C","G14874T","G15372T","-28271A","C29200T","G29227A"],"nsp10":["I55T"],"nsp12":["K478N"]},"labels":{"aa":"nsp10: I55T; nsp12: K478N"}}},{"name":"NODE_0000543","node_attrs":{"div":33,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.0917282104492188}},"branch_attrs":{"mutations":{"nuc":["G9053T"],"nsp4":["V167L"]},"labels":{"aa":"nsp4: V167L"}},"children":[{"name":"AY.1","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5589118003845215}},"branch_attrs":{"mutations":{"nuc":["G22335T","G22813T"],"S":["W258L","K417N"]},"labels":{"aa":"S: W258L, K417N","spike_mutations":"W258L, K417N"}}},{"name":"AY.105","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.105"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.105"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.082991123199463}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2939T"],"nsp3":["P74S"]},"labels":{"aa":"nsp3: P74S"}}},{"name":"AY.106","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.106"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.106"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6580145359039307}},"branch_attrs":{"mutations":{"nuc":["C9811T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"AY.109","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.109"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6555285453796387}},"branch_attrs":{"mutations":{"nuc":["A11595G","A14836G","T21846C","C27549T"],"S":["I95T"],"nsp12":["I466V"],"nsp6":["Q208R"]},"labels":{"aa":"S: I95T; nsp12: I466V; nsp6: Q208R","spike_mutations":"I95T"}}},{"name":"AY.107","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.107"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.107"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4870200157165527}},"branch_attrs":{"mutations":{"nuc":["A15012G","C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"AY.110","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.110"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.110"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.568274736404419}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","C912A"],"nsp1":["K141-","S142-","F143-"],"nsp2":["S36Y"]},"labels":{"aa":"nsp1: K141-, S142-, F143-; nsp2: S36Y"}}},{"name":"AY.112","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.112"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.112"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.2281134128570557}},"branch_attrs":{"mutations":{"nuc":["G25647T","-28271A"],"ORF3a":["L85F"]},"labels":{"aa":"ORF3a: L85F"}}},{"name":"AY.111","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.111"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.194126844406128}},"branch_attrs":{"mutations":{"nuc":["C4456T"]}}},{"name":"AY.117","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.117"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.117"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.009012460708618}},"branch_attrs":{"mutations":{"nuc":["A1G","G2202T","G14186T","C15810T","C28708T"],"nsp12":["R249M"],"nsp2":["W466L"]},"labels":{"aa":"nsp12: R249M; nsp2: W466L"}}},{"name":"AY.118","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.118"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.8720552921295166}},"branch_attrs":{"mutations":{"nuc":["A1C","T826C","A27338T"],"ORF6":["E46V"]},"labels":{"aa":"ORF6: E46V"}}},{"name":"AY.126","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.126"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.126"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6271045207977295}},"branch_attrs":{"mutations":{"nuc":["A1T","C14925T","A21137G","A24110C","A25439C"],"ORF3a":["K16T"],"S":["I850L"],"nsp16":["K160R"]},"labels":{"aa":"ORF3a: K16T; S: I850L; nsp16: K160R","spike_mutations":"I850L"}}},{"name":"AY.128","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.128"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.128"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.377318859100342}},"branch_attrs":{"mutations":{"nuc":["C2973T","G15906T","G16795T","T28150C"],"ORF8":["F86S"],"nsp12":["Q822H"],"nsp13":["V187L"],"nsp3":["A85V"]},"labels":{"aa":"ORF8: F86S; nsp12: Q822H; nsp13: V187L; nsp3: A85V"}}},{"name":"AY.129","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.129"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.129"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.10140061378479}},"branch_attrs":{"mutations":{"nuc":["A21194G","G28001T","T28156C"],"ORF8":["I88T"],"nsp16":["D179G"]},"labels":{"aa":"ORF8: I88T; nsp16: D179G"}}},{"name":"AY.132","node_attrs":{"div":48,"Nextclade_pango":{"value":"AY.132"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.132"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.301616191864014}},"branch_attrs":{"mutations":{"nuc":["G1418A","A2172G","C4754T","C7945T","G11161A","T11488C","G18213A","T19500C","A19908G","C23683T","C25710T","G25855T","C27131T","G27870T","C27881A"],"ORF3a":["D155Y"],"ORF7b":["E39*","H42Q"],"nsp14":["M58I"],"nsp15":["I96M"],"nsp2":["A205T","K456R"],"nsp3":["P679S"]},"labels":{"aa":"ORF3a: D155Y; ORF7b: E39*, H42Q; nsp14: M58I; nsp15: I96M; nsp2: A205T, K456R; nsp3: P679S"}}},{"name":"AY.131","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.131"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.789443492889404}},"branch_attrs":{"mutations":{"nuc":["C14407T","G19999T","G22899T","A23064C","T29014C","G29688T"],"S":["G446V","N501T"],"nsp12":["L323F"],"nsp15":["V127F"]},"labels":{"aa":"S: G446V, N501T; nsp12: L323F; nsp15: V127F","spike_mutations":"G446V, N501T"}}},{"name":"AY.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.4940871000289917}},"branch_attrs":{"mutations":{"nuc":["C7851T"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}}},{"name":"AY.4.10","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.4.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.10"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9287588596343994}},"branch_attrs":{"mutations":{"nuc":["C4320T","C5512T","C7851T","T8604C","C10714T","C12513T","A16602G","G20663A","C23996T","G25757T","T27900C"],"ORF3a":["R122I"],"ORF8":["F3L"],"S":["P812S"],"nsp16":["S2N"],"nsp3":["A534V","A1711V"],"nsp4":["F17S"],"nsp8":["T141M"]},"labels":{"aa":"ORF3a: R122I; ORF8: F3L; S: P812S; nsp16: S2N; nsp3: A534V, A1711V; nsp4: F17S; nsp8: T141M","spike_mutations":"P812S"}}},{"name":"AY.4.3","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.506161689758301}},"branch_attrs":{"mutations":{"nuc":["C7851T","C21638T"],"S":["P26S"],"nsp3":["A1711V"]},"labels":{"aa":"S: P26S; nsp3: A1711V","spike_mutations":"P26S"}}},{"name":"AY.4.4","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6225411891937256}},"branch_attrs":{"mutations":{"nuc":["C7851T","G14209T","C21575T","C22000T","G24348C"],"S":["L5F","S929T"],"nsp12":["V257F"],"nsp3":["A1711V"]},"labels":{"aa":"S: L5F, S929T; nsp12: V257F; nsp3: A1711V","spike_mutations":"L5F, S929T"}}},{"name":"AY.4.5","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9815378189086914}},"branch_attrs":{"mutations":{"nuc":["C7851T","A14882C","G25337T"],"S":["D1259Y"],"nsp12":["D481A"],"nsp3":["A1711V"]},"labels":{"aa":"S: D1259Y; nsp12: D481A; nsp3: A1711V","spike_mutations":"D1259Y"}}},{"name":"AY.4.8","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.8"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.532318115234375}},"branch_attrs":{"mutations":{"nuc":["C2706T","C7851T","C11450A","A12124G","G25489T","C29774T"],"ORF3a":["A33S"],"nsp2":["T634I"],"nsp3":["A1711V"],"nsp6":["Q160K"]},"labels":{"aa":"ORF3a: A33S; nsp2: T634I; nsp3: A1711V; nsp6: Q160K"}}},{"name":"AY.4.7","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.366204261779785}},"branch_attrs":{"mutations":{"nuc":["A1T","C7851T","G14829T","G17193T","G26416T","C28291T"],"E":["V58F"],"ORF9b":["P3L"],"nsp12":["M463I"],"nsp13":["E319D"],"nsp3":["A1711V"]},"labels":{"aa":"E: V58F; ORF9b: P3L; nsp12: M463I; nsp13: E319D; nsp3: A1711V"}}},{"name":"AY.44","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.44"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.44"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.8040610551834106}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14014G","T21846C","A29700G"],"S":["I95T"],"nsp12":["F192V"]},"labels":{"aa":"S: I95T; nsp12: F192V","spike_mutations":"I95T"}}},{"name":"AY.6","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7358286380767822}},"branch_attrs":{"mutations":{"nuc":["G2336A","G17331T","T21846C"],"S":["I95T"],"nsp13":["E365D"],"nsp2":["D511N"]},"labels":{"aa":"S: I95T; nsp13: E365D; nsp2: D511N","spike_mutations":"I95T"}}},{"name":"AY.76","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.76"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.76"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.444540977478027}},"branch_attrs":{"mutations":{"nuc":["T7233C","A16775G","T21846C"],"S":["I95T"],"nsp13":["Y180C"],"nsp3":["L1505S"]},"labels":{"aa":"S: I95T; nsp13: Y180C; nsp3: L1505S","spike_mutations":"I95T"}}},{"name":"AY.77","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.77"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:120-122"},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.77"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.144852638244629}},"branch_attrs":{"mutations":{"nuc":["C10376T","T21846C","T27346C","-28250T","-28251T","-28252T","-28253C"],"ORF6":["Y49H"],"S":["I95T"],"nsp5":["P108S"]},"labels":{"aa":"ORF6: Y49H; S: I95T; nsp5: P108S","spike_mutations":"I95T"}}},{"name":"AY.80","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.80"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.80"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.398502349853516}},"branch_attrs":{"mutations":{"nuc":["G5017A","G12479A","C19186T","G19735T","T21846C","G28028T"],"ORF8":["W45C"],"S":["I95T"],"nsp15":["D39Y"],"nsp8":["V130I"]},"labels":{"aa":"ORF8: W45C; S: I95T; nsp15: D39Y; nsp8: V130I","spike_mutations":"I95T"}}},{"name":"AY.81","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.81"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.81"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.495382308959961}},"branch_attrs":{"mutations":{"nuc":["G11358A","T21846C","C23643T","G25340T","A28032G","C28087T","C29530T"],"ORF8":["I47V","A65V"],"S":["I95T","A694V","D1260Y"],"nsp6":["R129K"]},"labels":{"aa":"ORF8: I47V, A65V; S: I95T, A694V, D1260Y; nsp6: R129K","spike_mutations":"I95T, A694V, D1260Y"}}},{"name":"AY.79","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.79"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.79"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.318887233734131}},"branch_attrs":{"mutations":{"nuc":["T2125C","T21846C"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}}},{"name":"AY.82","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.82"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.82"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3766937255859375}},"branch_attrs":{"mutations":{"nuc":["C9144T","T21846C","C22783T"],"S":["I95T"],"nsp4":["S197F"]},"labels":{"aa":"S: I95T; nsp4: S197F","spike_mutations":"I95T"}}},{"name":"AY.84","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.84"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.84"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8311426639556885}},"branch_attrs":{"mutations":{"nuc":["T21846C","C27297T","G28086T"],"ORF8":["A65S"],"S":["I95T"]},"labels":{"aa":"ORF8: A65S; S: I95T","spike_mutations":"I95T"}}},{"name":"AY.83","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.83"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.83"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.158646106719971}},"branch_attrs":{"mutations":{"nuc":["C5544T","G15243T","T21846C","A25491T"],"S":["I95T"],"nsp12":["M601I"],"nsp3":["T942I"]},"labels":{"aa":"S: I95T; nsp12: M601I; nsp3: T942I","spike_mutations":"I95T"}}},{"name":"AY.87","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.87"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.87"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.119286060333252}},"branch_attrs":{"mutations":{"nuc":["C832T","C2091T","C12651T","C17156T","A19815T","T21846C","G27556T"],"ORF7a":["A55S"],"S":["I95T"],"nsp13":["T307I"],"nsp2":["T429I"],"nsp8":["T187I"]},"labels":{"aa":"ORF7a: A55S; S: I95T; nsp13: T307I; nsp2: T429I; nsp8: T187I","spike_mutations":"I95T"}}},{"name":"AY.86","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.86"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.86"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.11639928817749}},"branch_attrs":{"mutations":{"nuc":["G15380T","T21846C","G24095T","C29445T"],"N":["T391I"],"S":["I95T","A845S"],"nsp12":["S647I"]},"labels":{"aa":"N: T391I; S: I95T, A845S; nsp12: S647I","spike_mutations":"I95T, A845S"}}},{"name":"AY.88","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.88"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.88"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.1931376457214355}},"branch_attrs":{"mutations":{"nuc":["G20709T","T21846C","C28724T"],"N":["P151S"],"S":["I95T"],"nsp16":["M17I"]},"labels":{"aa":"N: P151S; S: I95T; nsp16: M17I","spike_mutations":"I95T"}}},{"name":"AY.90","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.90"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.90"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9251A","G11083T","T21846C","C25931T","G26720A","G27990T","T28735C"],"ORF3a":["S180F"],"ORF8":["V33F"],"S":["I95T"],"nsp4":["V233I"],"nsp6":["L37F"]},"labels":{"aa":"ORF3a: S180F; ORF8: V33F; S: I95T; nsp4: V233I; nsp6: L37F","spike_mutations":"I95T"}}},{"name":"AY.94","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.94"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.94"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.735548973083496}},"branch_attrs":{"mutations":{"nuc":["G463A","G6367T","C15924T","G16975T","T21846C","C22987T"],"S":["I95T"],"nsp13":["V247F"],"nsp3":["Q1216H"]},"labels":{"aa":"S: I95T; nsp13: V247F; nsp3: Q1216H","spike_mutations":"I95T"}}},{"name":"AY.92","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.92"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.92"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.508190155029297}},"branch_attrs":{"mutations":{"nuc":["C28657T","C29167T"]}}},{"name":"AY.93","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.93"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.93"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6097846031188965}},"branch_attrs":{"mutations":{"nuc":["A1087G","C1101T","C7262T","T21846C"],"S":["I95T"],"nsp2":["S99F"],"nsp3":["L1515F"]},"labels":{"aa":"S: I95T; nsp2: S99F; nsp3: L1515F","spike_mutations":"I95T"}}},{"name":"NODE_0000544","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.529526472091675}},"branch_attrs":{"mutations":{"nuc":["C9559T","C15240T","T28007C"]}},"children":[{"name":"AY.101","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.101"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.101"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4137604236602783}},"branch_attrs":{"mutations":{"nuc":["C925T","C9474T","C25460T"],"ORF3a":["A23V"],"nsp4":["A307V"]},"labels":{"aa":"ORF3a: A23V; nsp4: A307V"}}},{"name":"AY.100","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.100"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.100"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2730963230133057}},"branch_attrs":{"mutations":{"nuc":["G17122T"],"nsp13":["A296S"]},"labels":{"aa":"nsp13: A296S"}}}]},{"name":"NODE_0000545","node_attrs":{"div":35,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.117180824279785}},"branch_attrs":{"mutations":{"nuc":["A17236G","T21846C"],"S":["I95T"],"nsp13":["I334V"]},"labels":{"aa":"S: I95T; nsp13: I334V","spike_mutations":"I95T"}},"children":[{"name":"AY.103","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.103"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.103"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.7256762981414795}},"branch_attrs":{"mutations":{"nuc":["C24208T"]}}},{"name":"AY.41","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.41"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.41"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3733155727386475}},"branch_attrs":{"mutations":{"nuc":["G1820A","G2272T","G7936T","G9220A","A13712G","C14119T","C18395T","G22346T","G22992T","G25062T","-28271A"],"S":["A262S","S477I","G1167V"],"nsp12":["K91R","P227S"],"nsp14":["A119V"],"nsp2":["G339S","K489N"]},"labels":{"aa":"S: A262S, S477I, G1167V; nsp12: K91R, P227S; nsp14: A119V; nsp2: G339S, K489N","spike_mutations":"A262S, S477I, G1167V"}}}]},{"name":"NODE_0000546","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.208604335784912}},"branch_attrs":{"mutations":{"nuc":["G16914T"]}},"children":[{"name":"AY.114","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.114"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.114"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.435467481613159}},"branch_attrs":{"mutations":{"nuc":["C884T","G19677T"],"nsp15":["Q19H"],"nsp2":["R27C"]},"labels":{"aa":"nsp15: Q19H; nsp2: R27C"}}},{"name":"AY.85","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.85"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.85"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.350363254547119}},"branch_attrs":{"mutations":{"nuc":["A708G","C1825T","T17748A","C25810T","G26428T","C26873T"],"E":["V62F"],"ORF3a":["L140F"],"nsp1":["E148G"]},"labels":{"aa":"E: V62F; ORF3a: L140F; nsp1: E148G"}}}]},{"name":"NODE_0000547","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.116"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.899040699005127}},"branch_attrs":{"mutations":{"nuc":["A10691G"],"nsp5":["I213V"]},"labels":{"aa":"nsp5: I213V"}},"children":[{"name":"AY.116","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.116"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.899040699005127}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.116.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.116.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.500979423522949}},"branch_attrs":{"mutations":{"nuc":["G12071A","C19160T","G20968A"],"nsp14":["S374F"],"nsp16":["V104I"],"nsp7":["D77N"]},"labels":{"aa":"nsp14: S374F; nsp16: V104I; nsp7: D77N"}}}]},{"name":"NODE_0000548","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.121"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.015531301498413}},"branch_attrs":{"mutations":{"nuc":["A1C","C13168T","C23557T","G25996T"],"ORF3a":["V202L"]},"labels":{"aa":"ORF3a: V202L"}},"children":[{"name":"AY.121.1","node_attrs":{"div":46,"Nextclade_pango":{"value":"AY.121.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4786579608917236}},"branch_attrs":{"mutations":{"nuc":["T209C","T6949C","C16726T","C19859T","C21648T","C27638T","C27737T","G28396A","G29690T"],"ORF7a":["A82V","T115I"],"ORF9b":["G38D"],"S":["T29I"],"nsp13":["H164Y"],"nsp15":["A80V"]},"labels":{"aa":"ORF7a: A82V, T115I; ORF9b: G38D; S: T29I; nsp13: H164Y; nsp15: A80V","spike_mutations":"T29I"}}},{"name":"AY.121","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.015531301498413}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000549","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.123"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.456477165222168}},"branch_attrs":{"mutations":{"nuc":["C897T","C5730T","A7519C","C15738T","G17790T","T21846C","C25350T","G27762T"],"ORF7b":["E3*"],"S":["I95T","P1263L"],"nsp13":["Q518H"],"nsp2":["A31V"],"nsp3":["T1004I"]},"labels":{"aa":"ORF7b: E3*; S: I95T, P1263L; nsp13: Q518H; nsp2: A31V; nsp3: T1004I","spike_mutations":"I95T, P1263L"}},"children":[{"name":"AY.123","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.456477165222168}},"branch_attrs":{"mutations":{}}},{"name":"AY.123.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.123.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.658041954040527}},"branch_attrs":{"mutations":{"nuc":["G20002T","A24410G"],"S":["N950D"],"nsp15":["D128Y"]},"labels":{"aa":"S: N950D; nsp15: D128Y","spike_mutations":"N950D"}}}]},{"name":"NODE_0000550","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.127"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1094322204589844}},"branch_attrs":{"mutations":{"nuc":["A1T","G25538T","C26054A"],"ORF3a":["G49V","T221K"]},"labels":{"aa":"ORF3a: G49V, T221K"}},"children":[{"name":"AY.127","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.127"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1094322204589844}},"branch_attrs":{"mutations":{}}},{"name":"AY.127.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.127.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6556131839752197}},"branch_attrs":{"mutations":{"nuc":["G242A","T7816C","A19445G","G23608T","C24138A","G28378T"],"ORF9b":["R32L"],"S":["T859N"],"nsp14":["K469R"]},"labels":{"aa":"ORF9b: R32L; S: T859N; nsp14: K469R","spike_mutations":"T859N"}}}]},{"name":"NODE_0000551","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.23"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3406074047088623}},"branch_attrs":{"mutations":{"nuc":["C1404T","C4752T","T21846C","G25352T"],"S":["I95T","V1264L"],"nsp2":["P200L"],"nsp3":["T678I"]},"labels":{"aa":"S: I95T, V1264L; nsp2: P200L; nsp3: T678I","spike_mutations":"I95T, V1264L"}},"children":[{"name":"AY.23","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3406074047088623}},"branch_attrs":{"mutations":{}}},{"name":"AY.23.1","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4683518409729004}},"branch_attrs":{"mutations":{"nuc":["C1263T","C5497T","A7537G","C12100T","A14748G","G17679T","T22213C","C25262A"],"S":["L1234I"],"nsp2":["T153M"]},"labels":{"aa":"S: L1234I; nsp2: T153M","spike_mutations":"L1234I"}}}]},{"name":"NODE_0000552","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.29"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5792689323425293}},"branch_attrs":{"mutations":{"nuc":["A1G","C5239T","T5514C"],"nsp3":["V932A"]},"labels":{"aa":"nsp3: V932A"}},"children":[{"name":"AY.29","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5792689323425293}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.29.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.29.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.489469528198242}},"branch_attrs":{"mutations":{"nuc":["G22081T"],"S":["Q173H"]},"labels":{"aa":"S: Q173H","spike_mutations":"Q173H"}}}]},{"name":"NODE_0000553","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.512903690338135}},"branch_attrs":{"mutations":{"nuc":["T21846C","C23277T","G24124A","-28271A"],"S":["I95T","T572I"]},"labels":{"aa":"S: I95T, T572I","spike_mutations":"I95T, T572I"}},"children":[{"name":"AY.32","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.32"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.96708345413208}},"branch_attrs":{"mutations":{"nuc":["C9286T","C21304T"],"nsp16":["R216C"]},"labels":{"aa":"nsp16: R216C"}}},{"name":"AY.95","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.95"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.95"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.070797920227051}},"branch_attrs":{"mutations":{"nuc":["T22293C"],"S":["L244S"]},"labels":{"aa":"S: L244S","spike_mutations":"L244S"}}}]},{"name":"NODE_0000554","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.33"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1432621479034424}},"branch_attrs":{"mutations":{"nuc":["A21647G","T21846C","C22311T"],"S":["T29A","I95T","T250I"]},"labels":{"aa":"S: T29A, I95T, T250I","spike_mutations":"T29A, I95T, T250I"}},"children":[{"name":"AY.33","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.33"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1432621479034424}},"branch_attrs":{"mutations":{}}},{"name":"AY.33.1","node_attrs":{"div":47,"Nextclade_pango":{"value":"AY.33.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":26},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:77-122"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C4182T","T10190C","A11111G","C14318T","C17439T","A18887G","G21010T","C21707T","C22458T","G23401T","G23522A","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-"],"S":["H49Y","T299I","Q613H","E654K"],"nsp12":["T293I"],"nsp14":["H283R"],"nsp16":["V118L"],"nsp3":["S488F"],"nsp5":["S46P"],"nsp6":["M47V"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-; S: H49Y, T299I, Q613H, E654K; nsp12: T293I; nsp14: H283R; nsp16: V118L; nsp3: S488F; nsp5: S46P; nsp6: M47V","spike_mutations":"H49Y, T299I, Q613H, E654K"}}}]},{"name":"NODE_0000555","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.42"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0401339530944824}},"branch_attrs":{"mutations":{"nuc":["G2258A","C12073T","C15237T","C25872T"],"nsp2":["V485I"]},"labels":{"aa":"nsp2: V485I"}},"children":[{"name":"AY.42","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.42"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0401339530944824}},"branch_attrs":{"mutations":{}}},{"name":"AY.42.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.734266996383667}},"branch_attrs":{"mutations":{"nuc":["T4081A","C23718T","C24374T"],"S":["T719I","L938F"],"nsp3":["S454R"]},"labels":{"aa":"S: T719I, L938F; nsp3: S454R","spike_mutations":"T719I, L938F"}}}]},{"name":"NODE_0000556","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.98"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.87161922454834}},"branch_attrs":{"mutations":{"nuc":["G526T","C19524T","T21846C"],"S":["I95T"],"nsp1":["E87D"]},"labels":{"aa":"S: I95T; nsp1: E87D","spike_mutations":"I95T"}},"children":[{"name":"AY.98","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.98"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.87161922454834}},"branch_attrs":{"mutations":{}}},{"name":"AY.98.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.98.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.623765707015991}},"branch_attrs":{"mutations":{"nuc":["G2518T","G5437T","C7768T","C22314T","G28086T"],"ORF8":["A65S"],"S":["P251L"],"nsp3":["E906D"]},"labels":{"aa":"ORF8: A65S; S: P251L; nsp3: E906D","spike_mutations":"P251L"}}}]},{"name":"NODE_0000557","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.102"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.505928039550781}},"branch_attrs":{"mutations":{"nuc":["G1495T","G11083T","A27690T","C29836T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"AY.102","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.505928039550781}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000558","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.102"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.112253189086914}},"branch_attrs":{"mutations":{"nuc":["A21987G","T25333C","A29700G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.102.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.102.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-5.035328388214111}},"branch_attrs":{"mutations":{"nuc":["G25218T"],"S":["G1219V"]},"labels":{"aa":"S: G1219V","spike_mutations":"G1219V"}}},{"name":"AY.102.2","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.102.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.796263694763184}},"branch_attrs":{"mutations":{"nuc":["C26395A","G29861T","G29862A","T29867-"],"E":["L51I"]},"labels":{"aa":"E: L51I"}}}]}]},{"name":"NODE_0000559","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8980414867401123}},"branch_attrs":{"mutations":{"nuc":["C745T"]}},"children":[{"name":"AY.104","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.104"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.104"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.190604209899902}},"branch_attrs":{"mutations":{"nuc":["T13048C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"AY.108","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.108"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.108"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.212310314178467}},"branch_attrs":{"mutations":{"nuc":["T2C","G370T","C823T","C6828T"],"nsp3":["S1370F"]},"labels":{"aa":"nsp3: S1370F"}}},{"name":"AY.125","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.125"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.125"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7532522678375244}},"branch_attrs":{"mutations":{"nuc":["C6730T","C13944T","G15906T","G18905A","G25471T","A26786G"],"ORF3a":["D27Y"],"nsp12":["Q822H"],"nsp14":["R289H"]},"labels":{"aa":"ORF3a: D27Y; nsp12: Q822H; nsp14: R289H"}}}]},{"name":"NODE_0000560","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5868980884552}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"AY.113","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.113"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.113"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0679993629455566}},"branch_attrs":{"mutations":{"nuc":["A1G","C9165T","A12772G","C15240T"],"nsp4":["T204I"]},"labels":{"aa":"nsp4: T204I"}}},{"name":"NODE_0000561","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.124"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5670838356018066}},"branch_attrs":{"mutations":{"nuc":["C1593T","C21301A"],"nsp16":["P215T"],"nsp2":["S263F"]},"labels":{"aa":"nsp16: P215T; nsp2: S263F"}},"children":[{"name":"AY.124","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.124"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5670838356018066}},"branch_attrs":{"mutations":{}}},{"name":"AY.124.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.124.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":35},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.139280796051025}},"branch_attrs":{"mutations":{"nuc":["C4276T","G25445T","G25720T","C26058T","G28628T"],"N":["A119S"],"ORF3a":["G18V","A110S"]},"labels":{"aa":"N: A119S; ORF3a: G18V, A110S"}}}]}]},{"name":"NODE_0000562","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.119"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9526422023773193}},"branch_attrs":{"mutations":{"nuc":["C8829T","G19006T"],"nsp14":["A323S"],"nsp4":["A92V"]},"labels":{"aa":"nsp14: A323S; nsp4: A92V"}},"children":[{"name":"AY.119","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.119"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9526422023773193}},"branch_attrs":{"mutations":{}}},{"name":"AY.119.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.119.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":38},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.377318382263184}},"branch_attrs":{"mutations":{"nuc":["C100T","C2973T","G17338T","C22227T","T24063C","G25552T","G26031T","T26621C","G29392T"],"N":["K373N"],"ORF3a":["A54S","Q213H"],"S":["A222V","I834T"],"nsp13":["A368S"],"nsp3":["A85V"]},"labels":{"aa":"N: K373N; ORF3a: A54S, Q213H; S: A222V, I834T; nsp13: A368S; nsp3: A85V","spike_mutations":"A222V, I834T"}}},{"name":"AY.119.2","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.119.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.131967067718506}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000563","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.25"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.314873695373535}},"branch_attrs":{"mutations":{"nuc":["A1G","T21846C","G26107C","A27507C"],"ORF3a":["E239Q"],"S":["I95T"]},"labels":{"aa":"ORF3a: E239Q; S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.25","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.25"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.314873695373535}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000564","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.25.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.4324440956115723}},"branch_attrs":{"mutations":{"nuc":["A3948G","G11562T"],"nsp3":["D410G"],"nsp6":["C197F"]},"labels":{"aa":"nsp3: D410G; nsp6: C197F"}},"children":[{"name":"AY.25.1.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.25.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.2396397590637207}},"branch_attrs":{"mutations":{"nuc":["G2564A","A21987G","G23948T"],"S":["D142G","D796Y"],"nsp2":["E587K"]},"labels":{"aa":"S: D142G, D796Y; nsp2: E587K","spike_mutations":"D142G, D796Y"}}},{"name":"AY.25.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.4324440956115723}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000565","node_attrs":{"div":35,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.468881368637085}},"branch_attrs":{"mutations":{"nuc":["T21846C","C25413T","-28271A"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.45","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.45"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.45"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.299954891204834}},"branch_attrs":{"mutations":{"nuc":["G13812T"],"nsp12":["M124I"]},"labels":{"aa":"nsp12: M124I"}}},{"name":"NODE_0000566","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.91"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.198517322540283}},"branch_attrs":{"mutations":{"nuc":["T1871C","C28236T","G29744A"],"ORF8":["R115C"],"nsp2":["F356L"]},"labels":{"aa":"ORF8: R115C; nsp2: F356L"}},"children":[{"name":"AY.91","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.91"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.198517322540283}},"branch_attrs":{"mutations":{}}},{"name":"AY.91.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.91.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.921102523803711}},"branch_attrs":{"mutations":{"nuc":["C15540T","C17010T","G25650T","A28271-","C28310T"],"N":["P13S"],"ORF3a":["L86F"]},"labels":{"aa":"N: P13S; ORF3a: L86F"}}}]}]},{"name":"NODE_0000567","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.7"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8977537155151367}},"branch_attrs":{"mutations":{"nuc":["T2C","G2944A","G11365T","G12718T","T21846C","G27566T","C27629A"],"ORF7a":["C58F","A79D"],"S":["I95T"],"nsp9":["Q11H"]},"labels":{"aa":"ORF7a: C58F, A79D; S: I95T; nsp9: Q11H","spike_mutations":"I95T"}},"children":[{"name":"AY.7.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1598989963531494}},"branch_attrs":{"mutations":{"nuc":["T15882G","A18675G"]}}},{"name":"AY.7","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8977537155151367}},"branch_attrs":{"mutations":{}}},{"name":"AY.7.2","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.7634453773498535}},"branch_attrs":{"mutations":{"nuc":["C2T","G25445T"],"ORF3a":["G18V"]},"labels":{"aa":"ORF3a: G18V"}}}]},{"name":"NODE_0000568","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.99"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.52271842956543}},"branch_attrs":{"mutations":{"nuc":["A3536G","T13216C","C15240T","T21846C"],"S":["I95T"],"nsp3":["I273V"]},"labels":{"aa":"S: I95T; nsp3: I273V","spike_mutations":"I95T"}},"children":[{"name":"AY.99","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.99"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.52271842956543}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000569","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.99"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.392517566680908}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.99.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.99.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.140461444854736}},"branch_attrs":{"mutations":{"nuc":["C8994T"],"nsp4":["T147I"]},"labels":{"aa":"nsp4: T147I"}}},{"name":"AY.99.2","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.99.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7914319038391113}},"branch_attrs":{"mutations":{"nuc":["C4927T","A5638G","C12525T"],"nsp8":["T145I"]},"labels":{"aa":"nsp8: T145I"}}}]}]},{"name":"NODE_0000570","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.120"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.007944345474243}},"branch_attrs":{"mutations":{"nuc":["C6408T","A25003G"],"nsp3":["S1230F"]},"labels":{"aa":"nsp3: S1230F"}},"children":[{"name":"AY.120","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.120"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.007944345474243}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.120.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.541743040084839}},"branch_attrs":{"mutations":{"nuc":["C11095T"]}}},{"name":"NODE_0000571","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.120.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.589193820953369}},"branch_attrs":{"mutations":{"nuc":["G174T","C21758T"],"S":["H66Y"]},"labels":{"aa":"S: H66Y","spike_mutations":"H66Y"}},"children":[{"name":"AY.120.2","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.120.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.589193820953369}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.2.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.120.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.859754800796509}},"branch_attrs":{"mutations":{"nuc":["C7105T","C13138T","T27017A"]}}}]}]},{"name":"NODE_0000572","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.122"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.137082099914551}},"branch_attrs":{"mutations":{"nuc":["G1048T","T21846C"],"S":["I95T"],"nsp2":["K81N"]},"labels":{"aa":"S: I95T; nsp2: K81N","spike_mutations":"I95T"}},"children":[{"name":"AY.122.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.122.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.737865447998047}},"branch_attrs":{"mutations":{"nuc":["G13892A","G14772A","G22793T"],"S":["A411S"],"nsp12":["C151Y"]},"labels":{"aa":"S: A411S; nsp12: C151Y","spike_mutations":"A411S"}}},{"name":"AY.122","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.122"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.137082099914551}},"branch_attrs":{"mutations":{}}},{"name":"AY.122.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.122.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.565906286239624}},"branch_attrs":{"mutations":{"nuc":["C19983T","G20937T","C23934T","C25516T"],"ORF3a":["P42S"],"S":["T791I"]},"labels":{"aa":"ORF3a: P42S; S: T791I","spike_mutations":"T791I"}}},{"name":"AY.122.3","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.122.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.337819576263428}},"branch_attrs":{"mutations":{"nuc":["T168C","C12513T","G17338A","T17694C","T20838C","G23401T","C27527T","C28873A"],"ORF7a":["P45L"],"S":["Q613H"],"nsp13":["A368T"],"nsp8":["T141M"]},"labels":{"aa":"ORF7a: P45L; S: Q613H; nsp13: A368T; nsp8: T141M","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000573","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3768041133880615}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"AY.22","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.22"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.22"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3188090324401855}},"branch_attrs":{"mutations":{"nuc":["G11083T","T12496C","G14209T","A21987G","G22216T","G26062T"],"ORF3a":["G224C"],"S":["D142G","Q218H"],"nsp12":["V257F"],"nsp6":["L37F"]},"labels":{"aa":"ORF3a: G224C; S: D142G, Q218H; nsp12: V257F; nsp6: L37F","spike_mutations":"D142G, Q218H"}}},{"name":"AY.36","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.36"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9737911224365234}},"branch_attrs":{"mutations":{"nuc":["T15628C","G18079T","A20532G","C29738T"],"nsp12":["C730R"],"nsp14":["V14L"]},"labels":{"aa":"nsp12: C730R; nsp14: V14L"}}},{"name":"NODE_0000574","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.20"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.005821704864502}},"branch_attrs":{"mutations":{"nuc":["C2061T"],"nsp2":["A419V"]},"labels":{"aa":"nsp2: A419V"}},"children":[{"name":"AY.20","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.20"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.005821704864502}},"branch_attrs":{"mutations":{}}},{"name":"AY.20.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.686790943145752}},"branch_attrs":{"mutations":{"nuc":["C8880T","G9190T","C11173T","C24106T","G25481T","C27393T","G29737T"],"ORF3a":["R30L"],"nsp4":["T109M"]},"labels":{"aa":"ORF3a: R30L; nsp4: T109M"}}}]}]},{"name":"NODE_0000575","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.3"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6765198707580566}},"branch_attrs":{"mutations":{"nuc":["T3C","A11456G","T21846C","G29050A","C29509T"],"S":["I95T"],"nsp6":["I162V"]},"labels":{"aa":"S: I95T; nsp6: I162V","spike_mutations":"I95T"}},"children":[{"name":"AY.3","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6765198707580566}},"branch_attrs":{"mutations":{}}},{"name":"AY.3.2","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8443009853363037}},"branch_attrs":{"mutations":{"nuc":["G5155A","C5784T","A10075G","A21987G","C22338T","C29546T","C29750T"],"S":["D142G","T259I"],"nsp3":["T1022I"]},"labels":{"aa":"S: D142G, T259I; nsp3: T1022I","spike_mutations":"D142G, T259I"}}},{"name":"NODE_0000576","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.3"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2108216285705566}},"branch_attrs":{"mutations":{"nuc":["T23284C","C25339T"]}},"children":[{"name":"AY.3.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9937119483947754}},"branch_attrs":{"mutations":{"nuc":["G3644T","C18115T","C20199T","A21987G"],"S":["D142G"],"nsp14":["H26Y"],"nsp3":["D309Y"]},"labels":{"aa":"S: D142G; nsp14: H26Y; nsp3: D309Y","spike_mutations":"D142G"}}},{"name":"AY.3.3","node_attrs":{"div":47,"Nextclade_pango":{"value":"AY.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.715099334716797}},"branch_attrs":{"mutations":{"nuc":["T2083C","A6229G","C9924T","T12538C","G21770A","A22803G","A26021C"],"ORF3a":["D210A"],"S":["V70I","Q414R"],"nsp4":["A457V"]},"labels":{"aa":"ORF3a: D210A; S: V70I, Q414R; nsp4: A457V","spike_mutations":"V70I, Q414R"}}}]}]},{"name":"NODE_0000577","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.34"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4385077953338623}},"branch_attrs":{"mutations":{"nuc":["A1G","G9441T","G18255T","C22498T","G23593C","G26109A","C26681T","G27014T"],"S":["Q677H"],"nsp14":["M72I"],"nsp4":["C296F"]},"labels":{"aa":"S: Q677H; nsp14: M72I; nsp4: C296F","spike_mutations":"Q677H"}},"children":[{"name":"AY.34","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.34"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4385077953338623}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.2","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.34.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":35},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6427252292633057}},"branch_attrs":{"mutations":{"nuc":["G11417T","A14457G","C21110T","C24138T"],"S":["T859I"],"nsp16":["T151I"],"nsp6":["V149F"]},"labels":{"aa":"S: T859I; nsp16: T151I; nsp6: V149F","spike_mutations":"T859I"}}},{"name":"NODE_0000578","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.34.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.636735677719116}},"branch_attrs":{"mutations":{"nuc":["C25355T","C28961T"],"N":["L230F"],"S":["L1265F"]},"labels":{"aa":"N: L230F; S: L1265F","spike_mutations":"L1265F"}},"children":[{"name":"AY.34.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.636735677719116}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.1.1","node_attrs":{"div":46,"Nextclade_pango":{"value":"AY.34.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8207154273986816}},"branch_attrs":{"mutations":{"nuc":["C2106T","G8017T","A21987G"],"S":["D142G"],"nsp2":["T434I"]},"labels":{"aa":"S: D142G; nsp2: T434I","spike_mutations":"D142G"}}}]}]},{"name":"NODE_0000579","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.39"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.785830497741699}},"branch_attrs":{"mutations":{"nuc":["G21372T","G27604A"],"ORF7a":["V71I"],"nsp16":["Q238H"]},"labels":{"aa":"ORF7a: V71I; nsp16: Q238H"}},"children":[{"name":"AY.39","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.785830497741699}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.2","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.39.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.734314203262329}},"branch_attrs":{"mutations":{"nuc":["G2494T","G5716T","C6883T","A21987G","G24781C"],"S":["D142G","K1073N"],"nsp2":["E563D"],"nsp3":["K999N"]},"labels":{"aa":"S: D142G, K1073N; nsp2: E563D; nsp3: K999N","spike_mutations":"D142G, K1073N"}}},{"name":"NODE_0000580","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.39.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0565383434295654}},"branch_attrs":{"mutations":{"nuc":["A13482G"]}},"children":[{"name":"AY.39.1.2","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.39.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:78-122"},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.295746326446533}},"branch_attrs":{"mutations":{"nuc":["G1577A","C18555T","C25568T","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF3a":["A59V"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"nsp2":["V258I"]},"labels":{"aa":"ORF3a: A59V; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; nsp2: V258I"}}},{"name":"AY.39.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0565383434295654}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.1.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.39.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3922364711761475}},"branch_attrs":{"mutations":{"nuc":["G19563T"],"nsp14":["L508F"]},"labels":{"aa":"nsp14: L508F"}}},{"name":"AY.39.1.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.39.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:78-122"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9028074741363525}},"branch_attrs":{"mutations":{"nuc":["G2164T","A21987G","C25046G","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"S":["D142G","P1162A"],"nsp2":["E453D"]},"labels":{"aa":"ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; S: D142G, P1162A; nsp2: E453D","spike_mutations":"D142G, P1162A"}}}]}]},{"name":"NODE_0000581","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.5"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3081870079040527}},"branch_attrs":{"mutations":{"nuc":["T21846C","G24928T"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.5","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3081870079040527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000582","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.5"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.431300640106201}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}},"children":[{"name":"AY.5.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.416350364685059}},"branch_attrs":{"mutations":{"nuc":["C12369T","C25572T"],"nsp8":["T93I"]},"labels":{"aa":"nsp8: T93I"}}},{"name":"AY.5.3","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8519368171691895}},"branch_attrs":{"mutations":{"nuc":["C7488T"],"nsp3":["T1590I"]},"labels":{"aa":"nsp3: T1590I"}}},{"name":"AY.5.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.63433313369751}},"branch_attrs":{"mutations":{"nuc":["C27143A"],"M":["N207K"]},"labels":{"aa":"M: N207K"}}},{"name":"AY.5.4","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.515988826751709}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"nsp2":["P129L"]},"labels":{"aa":"nsp2: P129L"}}},{"name":"AY.5.5","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C6840T","G17193T","T23398C"],"nsp13":["E319D"],"nsp3":["A1374V"]},"labels":{"aa":"nsp13: E319D; nsp3: A1374V"}}}]}]},{"name":"NODE_0000583","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.4"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.6842306852340698}},"branch_attrs":{"mutations":{"nuc":["C7851T","T17040C"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}},"children":[{"name":"AY.4.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.036841869354248}},"branch_attrs":{"mutations":{"nuc":["C2706T","T18927C","A20374C","G22899T"],"S":["G446V"],"nsp15":["I252L"],"nsp2":["T634I"]},"labels":{"aa":"S: G446V; nsp15: I252L; nsp2: T634I","spike_mutations":"G446V"}}},{"name":"AY.4.6","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1065313816070557}},"branch_attrs":{"mutations":{"nuc":["C16293T","C19524T","C20404T","A28967G"],"N":["S232G"],"nsp15":["P262S"]},"labels":{"aa":"N: S232G; nsp15: P262S"}}},{"name":"AY.4.9","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.9"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8668172359466553}},"branch_attrs":{"mutations":{"nuc":["C3140T","T4066A","C12513T"],"nsp3":["P141S"],"nsp8":["T141M"]},"labels":{"aa":"nsp3: P141S; nsp8: T141M"}}},{"name":"NODE_0000584","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5732269287109375}},"branch_attrs":{"mutations":{"nuc":["T21995C","C22227T","C25614T"],"S":["Y145H","A222V"]},"labels":{"aa":"S: Y145H, A222V","spike_mutations":"Y145H, A222V"}},"children":[{"name":"AY.4.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5732269287109375}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.2.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.4.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.891268253326416}},"branch_attrs":{"mutations":{"nuc":["C15720T","C18687T","G21668T","G28878T"],"N":["S202I"],"S":["V36F"]},"labels":{"aa":"N: S202I; S: V36F","spike_mutations":"V36F"}}},{"name":"AY.4.2.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4512696266174316}},"branch_attrs":{"mutations":{"nuc":["G26526T"],"M":["A2S"]},"labels":{"aa":"M: A2S"}}},{"name":"AY.4.2.2","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7742323875427246}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.46"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.140479564666748}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T","T21846C"],"S":["I95T"],"nsp6":["A2V"]},"labels":{"aa":"S: I95T; nsp6: A2V","spike_mutations":"I95T"}},"children":[{"name":"AY.46.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9886834621429443}},"branch_attrs":{"mutations":{"nuc":["T25673C"],"ORF3a":["L94P"]},"labels":{"aa":"ORF3a: L94P"}}},{"name":"AY.46.2","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8988404273986816}},"branch_attrs":{"mutations":{"nuc":["A17799G","-28271A"]}}},{"name":"AY.46","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.46"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.140479564666748}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.46.3","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.46.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["G11083T","G14186T","C19637T","A21987G","G28378T"],"ORF9b":["R32L"],"S":["D142G"],"nsp12":["R249M"],"nsp15":["A6V"],"nsp6":["L37F"]},"labels":{"aa":"ORF9b: R32L; S: D142G; nsp12: R249M; nsp15: A6V; nsp6: L37F","spike_mutations":"D142G"}}},{"name":"AY.46.5","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.46.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0682404041290283}},"branch_attrs":{"mutations":{"nuc":["C15569T","T16242G"],"nsp12":["T710I"]},"labels":{"aa":"nsp12: T710I"}}},{"name":"AY.46.4","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3499815464019775}},"branch_attrs":{"mutations":{"nuc":["G23545T"],"S":["E661D"]},"labels":{"aa":"S: E661D","spike_mutations":"E661D"}}},{"name":"AY.46.6","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.46.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.8154752254486084}},"branch_attrs":{"mutations":{"nuc":["C6310T","C8326T"]}}}]},{"name":"NODE_0000586","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.29671049118042}},"branch_attrs":{"mutations":{"nuc":["C15952A","T21846C","A28299T"],"N":["Q9L"],"ORF9b":["S6C"],"S":["I95T"],"nsp12":["L838I"]},"labels":{"aa":"N: Q9L; ORF9b: S6C; S: I95T; nsp12: L838I","spike_mutations":"I95T"}},"children":[{"name":"AY.43","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.43"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.29671049118042}},"branch_attrs":{"mutations":{}}},{"name":"AY.43.5","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.43.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["A17457G","A23064G","C23638T","C24937T","C28045T","G28857T","G29179T"],"N":["R195I"],"ORF8":["A51V"],"S":["N501S"]},"labels":{"aa":"N: R195I; ORF8: A51V; S: N501S","spike_mutations":"N501S"}}},{"name":"NODE_0000587","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2766566276550293}},"branch_attrs":{"mutations":{"nuc":["C18744T","C24130T"]}},"children":[{"name":"AY.43.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8277058601379395}},"branch_attrs":{"mutations":{"nuc":["C19955T"],"nsp15":["T112I"]},"labels":{"aa":"nsp15: T112I"}}},{"name":"AY.43.4","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.7761340141296387}},"branch_attrs":{"mutations":{"nuc":["C5241T"],"nsp3":["P841L"]},"labels":{"aa":"nsp3: P841L"}}},{"name":"AY.43.6","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.43.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3442533016204834}},"branch_attrs":{"mutations":{"nuc":["C233T","C1952A","T27409C","G29081T"],"N":["V270L"],"ORF7a":["F6L"],"nsp2":["Q383K"]},"labels":{"aa":"N: V270L; ORF7a: F6L; nsp2: Q383K"}}},{"name":"NODE_0000588","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.3868703842163086}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.43.2","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.43.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.030745029449463}},"branch_attrs":{"mutations":{"nuc":["G3728T"],"nsp3":["G337C"]},"labels":{"aa":"nsp3: G337C"}}},{"name":"AY.43.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.167747497558594}},"branch_attrs":{"mutations":{"nuc":["C12663T","C25433T"],"ORF3a":["T14I"],"nsp8":["A191V"]},"labels":{"aa":"ORF3a: T14I; nsp8: A191V"}}},{"name":"AY.43.7","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.43.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.19292688369751}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}}}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000589","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{"nuc":["G28881A","G28882A","G28883C"],"N":["R203K","G204R"]},"labels":{"aa":"N: R203K, G204R","clade":"20B"}},"children":[{"name":"B.1.1","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.111","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.111"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.111"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.088438510894775}},"branch_attrs":{"mutations":{"nuc":["T27447C","T29661C"],"ORF10":["F35S"]},"labels":{"aa":"ORF10: F35S"}}},{"name":"B.1.1.117","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.117"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.117"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.576686382293701}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"B.1.1.101","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.101"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.101"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.798060417175293}},"branch_attrs":{"mutations":{"nuc":["G8371T","G29868A"],"nsp3":["Q1884H"]},"labels":{"aa":"nsp3: Q1884H"}}},{"name":"B.1.1.115","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.115"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.115"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.550750732421875}},"branch_attrs":{"mutations":{"nuc":["G26918T","T29464C"]}}},{"name":"B.1.1.121","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.121"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.121"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.167267799377441}},"branch_attrs":{"mutations":{"nuc":["C27538T"]}}},{"name":"B.1.1.133","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.133"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.133"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4965T","A8072G","A16011G","A21213G"],"nsp3":["T749I","N1785D"]},"labels":{"aa":"nsp3: T749I, N1785D"}}},{"name":"B.1.1.141","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.141"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.141"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.266036510467529}},"branch_attrs":{"mutations":{"nuc":["T22020C","G26056T"],"ORF3a":["D222Y"],"S":["M153T"]},"labels":{"aa":"ORF3a: D222Y; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.135","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.135"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.135"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.479883193969727}},"branch_attrs":{"mutations":{"nuc":["C10376T"],"nsp5":["P108S"]},"labels":{"aa":"nsp5: P108S"}}},{"name":"B.1.1.161","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.161"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.161"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.094921588897705}},"branch_attrs":{"mutations":{"nuc":["G23403A"],"S":["G614D"]},"labels":{"aa":"S: G614D","spike_mutations":"G614D"}}},{"name":"B.1.1.163","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.163"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.163"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.996835231781006}},"branch_attrs":{"mutations":{"nuc":["G11029A","C21772T","C29518T"]}}},{"name":"B.1.1.157","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.157"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.157"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.1433210372924805}},"branch_attrs":{"mutations":{"nuc":["C6145T","G11272A","C17678T"],"nsp13":["T481M"],"nsp6":["M100I"]},"labels":{"aa":"nsp13: T481M; nsp6: M100I"}}},{"name":"B.1.1.176","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.176"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.176"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8188023567199707}},"branch_attrs":{"mutations":{"nuc":["C8208T","G9267A","T9667C","G25947T","G28361A"],"N":["G30R"],"ORF3a":["Q185H"],"ORF9b":["M26I"],"nsp3":["T1830I"],"nsp4":["S238N"]},"labels":{"aa":"N: G30R; ORF3a: Q185H; ORF9b: M26I; nsp3: T1830I; nsp4: S238N"}}},{"name":"B.1.1.171","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.171"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.171"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.768898010253906}},"branch_attrs":{"mutations":{"nuc":["C1437T","G29745T"],"nsp2":["S211F"]},"labels":{"aa":"nsp2: S211F"}}},{"name":"B.1.1.186","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.186"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.186"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.552818775177002}},"branch_attrs":{"mutations":{"nuc":["C4113T","G21974C","C23191T"],"S":["D138H"],"nsp3":["A465V"]},"labels":{"aa":"S: D138H; nsp3: A465V","spike_mutations":"D138H"}}},{"name":"B.1.1.174","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.174"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.174"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.572410583496094}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.1.189","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.189"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.189"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.426564693450928}},"branch_attrs":{"mutations":{"nuc":["C9430T","C12823T"]}}},{"name":"B.1.1.192","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.192"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.192"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.360202312469482}},"branch_attrs":{"mutations":{"nuc":["A1G","C673T"]}}},{"name":"B.1.1.203","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.203"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.203"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.988719463348389}},"branch_attrs":{"mutations":{"nuc":["C23854T"]}}},{"name":"B.1.1.205","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.205"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.205"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.790339946746826}},"branch_attrs":{"mutations":{"nuc":["G5539A","G21468A"],"nsp16":["M270I"]},"labels":{"aa":"nsp16: M270I"}}},{"name":"B.1.1.198","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.198"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.198"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.466243743896484}},"branch_attrs":{"mutations":{"nuc":["C3261T","A15984T","C20946T"],"nsp3":["T181I"]},"labels":{"aa":"nsp3: T181I"}}},{"name":"B.1.1.207","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.207"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.207"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.1433210372924805}},"branch_attrs":{"mutations":{"nuc":["T9172C","A10948G","C10977T","C23604A","A24874G","G26730T","A26927G"],"M":["V70F"],"S":["P681H"],"nsp6":["A2V"]},"labels":{"aa":"M: V70F; S: P681H; nsp6: A2V","spike_mutations":"P681H"}}},{"name":"B.1.1.231","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.231"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.231"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.254888534545898}},"branch_attrs":{"mutations":{"nuc":["A1G","A25505C"],"ORF3a":["Q38P"]},"labels":{"aa":"ORF3a: Q38P"}}},{"name":"B.1.1.232","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.232"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.232"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.283545970916748}},"branch_attrs":{"mutations":{"nuc":["T2537G","G12191T","T16479C"],"nsp2":["L578V"],"nsp8":["V34F"]},"labels":{"aa":"nsp2: L578V; nsp8: V34F"}}},{"name":"B.1.1.241","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.241"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.241"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.24725866317749}},"branch_attrs":{"mutations":{"nuc":["A11782G","T21570G","C21575T","T25473C","C28253T"],"S":["V3G","L5F"]},"labels":{"aa":"S: V3G, L5F","spike_mutations":"V3G, L5F"}}},{"name":"B.1.1.243","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.243"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.243"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.795328617095947}},"branch_attrs":{"mutations":{"nuc":["C5339T","A9900C","C12733A"],"nsp3":["P874S"],"nsp4":["N449T"]},"labels":{"aa":"nsp3: P874S; nsp4: N449T"}}},{"name":"B.1.1.228","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.228"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.228"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.376809597015381}},"branch_attrs":{"mutations":{"nuc":["A20288G","C21721T","C26894T","C28638A"],"N":["P122H"],"nsp15":["E223G"]},"labels":{"aa":"N: P122H; nsp15: E223G"}}},{"name":"B.1.1.253","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.253"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.253"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.5802154541015625}},"branch_attrs":{"mutations":{"nuc":["T19893C"]}}},{"name":"B.1.1.263","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.263"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.263"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.347754001617432}},"branch_attrs":{"mutations":{"nuc":["G5924A","T21775G"],"nsp3":["V1069I"]},"labels":{"aa":"nsp3: V1069I"}}},{"name":"B.1.1.265","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.265"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.265"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.463467121124268}},"branch_attrs":{"mutations":{"nuc":["C11005A","A28624T"],"nsp6":["H11Q"]},"labels":{"aa":"nsp6: H11Q"}}},{"name":"B.1.1.269","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.269"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.269"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.337708950042725}},"branch_attrs":{"mutations":{"nuc":["C5055T","G11851T","G24812T","C26895T"],"M":["H125Y"],"S":["D1084Y"],"nsp3":["T779I"],"nsp7":["M3I"]},"labels":{"aa":"M: H125Y; S: D1084Y; nsp3: T779I; nsp7: M3I","spike_mutations":"D1084Y"}}},{"name":"B.1.1.274","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.274"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.274"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.456281661987305}},"branch_attrs":{"mutations":{"nuc":["G25912T"],"ORF3a":["G174C"]},"labels":{"aa":"ORF3a: G174C"}}},{"name":"B.1.1.277","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.277"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.277"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.125593185424805}},"branch_attrs":{"mutations":{"nuc":["A1G","T772C","A2869G","C10868T","G15652T","C29095T"],"nsp12":["D738Y"]},"labels":{"aa":"nsp12: D738Y"}}},{"name":"B.1.1.294","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.294"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.294"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.174777507781982}},"branch_attrs":{"mutations":{"nuc":["C3373A","C6883T","G21724A"],"nsp3":["D218E"]},"labels":{"aa":"nsp3: D218E"}}},{"name":"B.1.1.297","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.297"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.297"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4372172355651855}},"branch_attrs":{"mutations":{"nuc":["A20742C","T27922C"],"ORF8":["I10T"],"nsp16":["Q28H"]},"labels":{"aa":"ORF8: I10T; nsp16: Q28H"}}},{"name":"B.1.1.298","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.298"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.298"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.08450984954834}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22920T","C25936T"],"ORF3a":["H182Y"],"S":["Y453F"],"nsp12":["T739I"]},"labels":{"aa":"ORF3a: H182Y; S: Y453F; nsp12: T739I","spike_mutations":"Y453F"}}},{"name":"B.1.1.307","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.307"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.307"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.859855890274048}},"branch_attrs":{"mutations":{"nuc":["G1210T","G9802T","G12067T"],"nsp2":["M135I"],"nsp7":["M75I"]},"labels":{"aa":"nsp2: M135I; nsp7: M75I"}}},{"name":"B.1.1.311","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.311"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.311"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.807455539703369}},"branch_attrs":{"mutations":{"nuc":["G11230T","T24088C","G25617T"],"ORF3a":["K75N"],"nsp6":["M86I"]},"labels":{"aa":"ORF3a: K75N; nsp6: M86I"}}},{"name":"B.1.1.329","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.329"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.329"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.522212982177734}},"branch_attrs":{"mutations":{"nuc":["A2132C","A10323G","G10360A"],"nsp2":["K443Q"],"nsp5":["K90R"]},"labels":{"aa":"nsp2: K443Q; nsp5: K90R"}}},{"name":"B.1.1.348","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.348"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.348"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.967780828475952}},"branch_attrs":{"mutations":{"nuc":["C25521T","C29870A"]}}},{"name":"B.1.1.359","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.359"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.359"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.396486759185791}},"branch_attrs":{"mutations":{"nuc":["A28305G"],"N":["N11S"],"ORF9b":["M8V"]},"labels":{"aa":"N: N11S; ORF9b: M8V"}}},{"name":"B.1.1.368","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.368"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.437197208404541}},"branch_attrs":{"mutations":{"nuc":["C9996T","G27798T","G29402T"],"N":["D377Y"],"ORF7b":["A15S"],"nsp4":["S481L"]},"labels":{"aa":"N: D377Y; ORF7b: A15S; nsp4: S481L"}}},{"name":"B.1.1.371","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.371"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.371"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.790440082550049}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"nsp13":["S74P"]},"labels":{"aa":"nsp13: S74P"}}},{"name":"B.1.1.37","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.37"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.50777268409729}},"branch_attrs":{"mutations":{"nuc":["C21637T","A28169G"]}}},{"name":"B.1.1.370","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.370"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.370"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.376","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.376"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.376"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.82697057723999}},"branch_attrs":{"mutations":{"nuc":["A6716G","G11596T"],"nsp3":["S1333G"],"nsp6":["Q208H"]},"labels":{"aa":"nsp3: S1333G; nsp6: Q208H"}}},{"name":"B.1.1.374","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.374"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C344A","T1456C","C8595T","C8836T","G11222T","C22792T","T22917A","T26047G"],"ORF3a":["L219V"],"S":["L452Q"],"nsp1":["L27I"],"nsp4":["T14I"],"nsp6":["V84F"]},"labels":{"aa":"ORF3a: L219V; S: L452Q; nsp1: L27I; nsp4: T14I; nsp6: V84F","spike_mutations":"L452Q"}}},{"name":"B.1.1.378","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.378"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.7187089920043945}},"branch_attrs":{"mutations":{"nuc":["C29284T","C29870A"]}}},{"name":"B.1.1.39","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.39"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9360599517822266}},"branch_attrs":{"mutations":{"nuc":["G9130T","T27319C","G28487A","C28868T"],"N":["V72I","P199S"]},"labels":{"aa":"N: V72I, P199S"}}},{"name":"B.1.1.391","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.391"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.083807468414307}},"branch_attrs":{"mutations":{"nuc":["T7171C","C27002T"]}}},{"name":"B.1.1.398","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.398"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.421121597290039}},"branch_attrs":{"mutations":{"nuc":["C5806T"]}}},{"name":"B.1.1.409","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.409"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.409"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.404","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.404"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.653604507446289}},"branch_attrs":{"mutations":{"nuc":["T19275A","G20548T","G26211T","C26534T"],"nsp15":["D310Y"]},"labels":{"aa":"nsp15: D310Y"}}},{"name":"B.1.1.411","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.411"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.411"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.420","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.420"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.420"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.130832672119141}},"branch_attrs":{"mutations":{"nuc":["T847C","G3994T","C5178T","C5548T","A11451G","C13694T","T18132C","C21614T","T22882G","A24373G","G25839T","C28310T","T28862A"],"N":["P13S","S197T"],"ORF3a":["W149C"],"S":["L18F","N440K"],"nsp12":["T85I"],"nsp3":["T820I"],"nsp6":["Q160R"]},"labels":{"aa":"N: P13S, S197T; ORF3a: W149C; S: L18F, N440K; nsp12: T85I; nsp3: T820I; nsp6: Q160R","spike_mutations":"L18F, N440K"}}},{"name":"B.1.1.419","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.419"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.419"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.432","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.432"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.432"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0862812995910645}},"branch_attrs":{"mutations":{"nuc":["A6985T","C9319T","C12412T","T14313C"]}}},{"name":"B.1.1.44","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.44"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.218751907348633}},"branch_attrs":{"mutations":{"nuc":["G28884T"],"N":["R204L"]},"labels":{"aa":"N: R204L"}}},{"name":"B.1.1.442","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.442"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.442"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.316291809082031}},"branch_attrs":{"mutations":{"nuc":["A3879-","G3880-","A3881-","T3882-","T3883-","C3884-","C3885-","T3886-","A3887-","A3888-","A3889-","G3890-","A3891-","G3892-","G3893-","A3894-","A3895-","G3896-","T3897-","T3898-","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","A3908-","C13432T","C29409T"],"N":["T379I"],"nsp3":["E387-","I388-","P389-","K390-","E391-","E392-","V393-","K394-","P395-","F396-","I397V"]},"labels":{"aa":"N: T379I; nsp3: E387-, I388-, P389-, K390-, E391-, E392-, V393-, K394-, P395-, F396-, I397V"}}},{"name":"B.1.1.462","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.462"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.462"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.088257789611816}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.1.485","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.485"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.902052879333496}},"branch_attrs":{"mutations":{"nuc":["C745T"]}}},{"name":"B.1.1.487","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.487"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.487"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.5293731689453125}},"branch_attrs":{"mutations":{"nuc":["A20374G"],"nsp15":["I252V"]},"labels":{"aa":"nsp15: I252V"}}},{"name":"B.1.1.500","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.500"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.500"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.359736442565918}},"branch_attrs":{"mutations":{"nuc":["T23689C","C29230T"]}}},{"name":"B.1.1.52","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.52"},"qc.stopCodons.totalStopCodons":{"value":1},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":56.25},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.52"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.176274299621582}},"branch_attrs":{"mutations":{"nuc":["G8T","T9C","A12T","T14222G","T29867A"],"nsp12":["L261*"]},"labels":{"aa":"nsp12: L261*"}}},{"name":"B.1.1.525","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.525"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.525"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1C","T2C","T3478G","C8299T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12781T","A16550C","C16887T","C18252T","T21992-","A21993-","T21994-","G23012A","C23525T","A28271C","G28916T"],"N":["G215C"],"S":["Y144-","E484K","H655Y"],"nsp13":["D105A"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: G215C; S: Y144-, E484K, H655Y; nsp13: D105A; nsp6: S106-, G107-, F108-","spike_mutations":"Y144-, E484K, H655Y"}}},{"name":"B.1.1.53","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.53"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.88819694519043}},"branch_attrs":{"mutations":{"nuc":["G9890T","A20318G"],"nsp15":["E233G"],"nsp4":["A446S"]},"labels":{"aa":"nsp15: E233G; nsp4: A446S"}}},{"name":"B.1.1.57","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.57"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.502486705780029}},"branch_attrs":{"mutations":{"nuc":["C20234T"],"nsp15":["P205L"]},"labels":{"aa":"nsp15: P205L"}}},{"name":"B.1.1.63","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.63"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7540249824523926}},"branch_attrs":{"mutations":{"nuc":["C21597T","C29144T"],"S":["S12F"]},"labels":{"aa":"S: S12F","spike_mutations":"S12F"}}},{"name":"B.1.1.61","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.61"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.910613059997559}},"branch_attrs":{"mutations":{"nuc":["G18898T"],"nsp14":["V287F"]},"labels":{"aa":"nsp14: V287F"}}},{"name":"B.1.1.83","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.83"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.83"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.403122901916504}},"branch_attrs":{"mutations":{"nuc":["C1420T"]}}},{"name":"B.1.1.99","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.99"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.99"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.924996376037598}},"branch_attrs":{"mutations":{"nuc":["C28005T","C29870A"],"ORF8":["P38S"]},"labels":{"aa":"ORF8: P38S"}}},{"name":"B.1.533","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.533"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.533"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.071420192718506}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"NODE_0000590","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.10"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.221151828765869}},"branch_attrs":{"mutations":{"nuc":["C19170T","G19509A"]}},"children":[{"name":"B.1.1.10","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.221151828765869}},"branch_attrs":{"mutations":{}}},{"name":"L.3","node_attrs":{"div":20,"Nextclade_pango":{"value":"L.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.097338676452637}},"branch_attrs":{"mutations":{"nuc":["C1601T","G4399T","C4543T","G8179T","C8481T","A9453C","C19269T","T22917G","A25026T","G25244T","A26927G"],"S":["L452R","Y1155F","V1228L"],"nsp2":["L266F"],"nsp3":["M560I","P1921L"],"nsp4":["Y300S"]},"labels":{"aa":"S: L452R, Y1155F, V1228L; nsp2: L266F; nsp3: M560I, P1921L; nsp4: Y300S","spike_mutations":"L452R, Y1155F, V1228L"}}}]},{"name":"NODE_0000591","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.131749153137207}},"branch_attrs":{"mutations":{"nuc":["C13887T","C23248T"]}},"children":[{"name":"B.1.1.153","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.153"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.153"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C1912T","T9151C","C9693T","T16456C"],"nsp13":["S74P"],"nsp4":["A380V"]},"labels":{"aa":"nsp13: S74P; nsp4: A380V"}}},{"name":"B.1.1.170","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.170"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.170"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.35718297958374}},"branch_attrs":{"mutations":{"nuc":["C2062T","C5184A","C18687T"],"nsp3":["P822H"]},"labels":{"aa":"nsp3: P822H"}}}]},{"name":"NODE_0000592","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.607780456542969}},"branch_attrs":{"mutations":{"nuc":["C9120T"],"nsp4":["T189I"]},"labels":{"aa":"nsp4: T189I"}},"children":[{"name":"B.1.1.159","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.159"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.159"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.915672302246094}},"branch_attrs":{"mutations":{"nuc":["G6865T","A9204C","C15237T","C28290T"],"N":["P6L"],"ORF9b":["P3S"],"nsp3":["K1382N"],"nsp4":["D217A"]},"labels":{"aa":"N: P6L; ORF9b: P3S; nsp3: K1382N; nsp4: D217A"}}},{"name":"B.1.1.302","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.302"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.302"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4443230628967285}},"branch_attrs":{"mutations":{"nuc":["C7267T","C18032T","C20233T","G24926T","A27674T","A29350G"],"ORF7a":["Q94L"],"S":["V1122L"],"nsp13":["T599I"],"nsp15":["P205S"]},"labels":{"aa":"ORF7a: Q94L; S: V1122L; nsp13: T599I; nsp15: P205S","spike_mutations":"V1122L"}}}]},{"name":"NODE_0000593","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.96992301940918}},"branch_attrs":{"mutations":{"nuc":["C1427T"],"nsp2":["H208Y"]},"labels":{"aa":"nsp2: H208Y"}},"children":[{"name":"B.1.1.254","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.254"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.254"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.96992301940918}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.507","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.507"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.507"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["G1042A","C12253T","G19656A"]}}}]},{"name":"NODE_0000594","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.194224834442139}},"branch_attrs":{"mutations":{"nuc":["G21624T"],"S":["R21I"]},"labels":{"aa":"S: R21I","spike_mutations":"R21I"}},"children":[{"name":"B.1.1.279","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.279"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.279"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.194469928741455}},"branch_attrs":{"mutations":{"nuc":["C1419T","C4158T","C8318A","G18859T"],"nsp14":["A274S"],"nsp2":["A205V"],"nsp3":["A480V","P1867T"]},"labels":{"aa":"nsp14: A274S; nsp2: A205V; nsp3: A480V, P1867T"}}},{"name":"B.1.1.360","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.360"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.360"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.070964336395264}},"branch_attrs":{"mutations":{"nuc":["G25598T"],"ORF3a":["W69L"]},"labels":{"aa":"ORF3a: W69L"}}}]},{"name":"NODE_0000595","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.927735328674316}},"branch_attrs":{"mutations":{"nuc":["C936T","G3259T"],"nsp2":["T44I"],"nsp3":["Q180H"]},"labels":{"aa":"nsp2: T44I; nsp3: Q180H"}},"children":[{"name":"B.1.1.304","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.304"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.304"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.927735328674316}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.434","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.434"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.434"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2342G","C11591T","G17122T","C18348T","A26069G"],"ORF3a":["E226G"],"nsp13":["A296S"],"nsp2":["I513V"],"nsp6":["L207F"]},"labels":{"aa":"ORF3a: E226G; nsp13: A296S; nsp2: I513V; nsp6: L207F"}}}]},{"name":"NODE_0000596","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.98975133895874}},"branch_attrs":{"mutations":{"nuc":["C25528T"],"ORF3a":["L46F"]},"labels":{"aa":"ORF3a: L46F"}},"children":[{"name":"B.1.1.326","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.326"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.326"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.312747478485107}},"branch_attrs":{"mutations":{"nuc":["A12C","G4354A","C6573T"],"nsp3":["S1285F"]},"labels":{"aa":"nsp3: S1285F"}}},{"name":"B.1.1.8","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.8"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.98975133895874}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000597","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.590047836303711}},"branch_attrs":{"mutations":{"nuc":["A1G","C12053T","G25088T"],"S":["V1176F"],"nsp7":["L71F"]},"labels":{"aa":"S: V1176F; nsp7: L71F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.332","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.332"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.332"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["C442A","C6310T","G11417T","T16944C","G26062C"],"ORF3a":["G224R"],"nsp6":["V149F"]},"labels":{"aa":"ORF3a: G224R; nsp6: V149F"}}},{"name":"P.7","node_attrs":{"div":21,"Nextclade_pango":{"value":"P.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.7"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C1288T","C7124T","C7765T","G8027T","C9344T","G10870T","G11596T","C17172T","C17676T","C25844T","C28311T"],"N":["P13L"],"ORF3a":["T151I"],"ORF9b":["P10S"],"nsp3":["P1469S","V1770F"],"nsp4":["L264F"],"nsp6":["Q208H"]},"labels":{"aa":"N: P13L; ORF3a: T151I; ORF9b: P10S; nsp3: P1469S, V1770F; nsp4: L264F; nsp6: Q208H"}}}]},{"name":"NODE_0000598","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9660351276397705}},"branch_attrs":{"mutations":{"nuc":["G21974T"],"S":["D138Y"]},"labels":{"aa":"S: D138Y","spike_mutations":"D138Y"}},"children":[{"name":"B.1.1.397","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.397"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.451379776000977}},"branch_attrs":{"mutations":{"nuc":["T22020C","G28077T","G28975T"],"N":["M234I"],"ORF8":["V62L"],"S":["M153T"]},"labels":{"aa":"N: M234I; ORF8: V62L; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.413","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.1.413"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.413"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A604G","C3096T","G13849T","A19020T","G22992A","A26741G","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","C28291T","C29311T"],"M":["I73M"],"ORF8":["G66-","S67-","K68E"],"ORF9b":["P3L"],"S":["S477N"],"nsp12":["G137C"],"nsp3":["S126L"]},"labels":{"aa":"M: I73M; ORF8: G66-, S67-, K68E; ORF9b: P3L; S: S477N; nsp12: G137C; nsp3: S126L","spike_mutations":"S477N"}}}]},{"name":"NODE_0000599","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.683711051940918}},"branch_attrs":{"mutations":{"nuc":["T12503C","C29721T"],"nsp8":["Y138H"]},"labels":{"aa":"nsp8: Y138H"}},"children":[{"name":"B.1.1.448","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.448"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.683711051940918}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.54","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.54"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.678201675415039}},"branch_attrs":{"mutations":{"nuc":["C6762T","G25770T"],"ORF3a":["R126S"],"nsp3":["T1348I"]},"labels":{"aa":"ORF3a: R126S; nsp3: T1348I"}}}]},{"name":"NODE_0000600","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.747574806213379}},"branch_attrs":{"mutations":{"nuc":["C21648T"],"S":["T29I"]},"labels":{"aa":"S: T29I","spike_mutations":"T29I"}},"children":[{"name":"B.1.1.486","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.486"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["C12439T","C23277T","G23593T","G24368A","G25565A","C25624T","T27242C","C27630T","G28975T","G29332T","G29751T"],"N":["M234I"],"ORF3a":["S58N","H78Y"],"ORF6":["I14T"],"S":["T572I","Q677H","D936N"]},"labels":{"aa":"N: M234I; ORF3a: S58N, H78Y; ORF6: I14T; S: T572I, Q677H, D936N","spike_mutations":"T572I, Q677H, D936N"}}},{"name":"B.1.1.67","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.67"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.898261547088623}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"nsp6":["D159N"]},"labels":{"aa":"nsp6: D159N"}}}]},{"name":"NODE_0000601","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.247831344604492}},"branch_attrs":{"mutations":{"nuc":["C26060T"],"ORF3a":["T223I"]},"labels":{"aa":"ORF3a: T223I"}},"children":[{"name":"B.1.1.216","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.216"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.216"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.874875545501709}},"branch_attrs":{"mutations":{"nuc":["A1T","C5884T"]}}},{"name":"B.1.1.416","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.416"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.416"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.05353307723999}},"branch_attrs":{"mutations":{"nuc":["C16386T","C20762T"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"B.1.1.433","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.433"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.433"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.377383708953857}},"branch_attrs":{"mutations":{"nuc":["C313T","G3692T","C5007T","A11991G","G14584A","C14805T","T15114C","C15848T","G20940T","C22993G","G23580C","T23599A","G26217T","G26951C","T27900C"],"ORF3a":["L275F"],"ORF8":["F3L"],"S":["S477R","S673T","N679K"],"nsp12":["A382T","T803I"],"nsp3":["V325F","T763M"],"nsp7":["E50G"]},"labels":{"aa":"ORF3a: L275F; ORF8: F3L; S: S477R, S673T, N679K; nsp12: A382T, T803I; nsp3: V325F, T763M; nsp7: E50G","spike_mutations":"S477R, S673T, N679K"}}}]},{"name":"NODE_0000602","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.30653190612793}},"branch_attrs":{"mutations":{"nuc":["G10265A"],"nsp5":["G71S"]},"labels":{"aa":"nsp5: G71S"}},"children":[{"name":"B.1.1.27","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.27"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.767889499664307}},"branch_attrs":{"mutations":{"nuc":["C16293T"]}}},{"name":"B.1.1.301","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.301"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.301"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.301366329193115}},"branch_attrs":{"mutations":{"nuc":["A9433T","A19650G"]}}},{"name":"B.1.1.70","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.70"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.70"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.566112756729126}},"branch_attrs":{"mutations":{"nuc":["A15972G","C19718T","T28759C"],"nsp15":["T33I"]},"labels":{"aa":"nsp15: T33I"}}}]},{"name":"NODE_0000603","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.859383583068848}},"branch_attrs":{"mutations":{"nuc":["C22675T"]}},"children":[{"name":"B.1.1.273","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.273"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.273"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.873911380767822}},"branch_attrs":{"mutations":{"nuc":["A7064G"],"nsp3":["R1449G"]},"labels":{"aa":"nsp3: R1449G"}}},{"name":"B.1.1.412","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.412"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.412"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.9886064529418945}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"nsp6":["D159N"]},"labels":{"aa":"nsp6: D159N"}}},{"name":"B.1.1.56","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.56"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["T9508C","G23868T","G24794T"],"S":["G769V","A1078S"]},"labels":{"aa":"S: G769V, A1078S","spike_mutations":"G769V, A1078S"}}}]},{"name":"NODE_0000604","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.898122787475586}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"B.1.1.312","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.312"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.312"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420844554901123}},"branch_attrs":{"mutations":{"nuc":["C2455T","C14625T","C19018T","A24432T","A28081G"],"ORF8":["D63G"],"S":["Q957L"],"nsp14":["P327S"]},"labels":{"aa":"ORF8: D63G; S: Q957L; nsp14: P327S","spike_mutations":"Q957L"}}},{"name":"B.1.1.406","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.406"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.8544087409973145}},"branch_attrs":{"mutations":{"nuc":["C683T","C7051T","C7303T","C8964T","G25314T","C29296T","G29744A"],"S":["G1251V"],"nsp4":["S137L"]},"labels":{"aa":"S: G1251V; nsp4: S137L","spike_mutations":"G1251V"}}},{"name":"B.1.1.417","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.417"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.417"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.553451061248779}},"branch_attrs":{"mutations":{"nuc":["A2871G","C11455T","T12433C","C16997T","C17285T","A17739G","C19017T","G19072T","C20823T","G21800T","C25416T","G29781T"],"S":["D80Y"],"nsp13":["P254L","S350L"],"nsp14":["D345Y"],"nsp3":["N51S"]},"labels":{"aa":"S: D80Y; nsp13: P254L, S350L; nsp14: D345Y; nsp3: N51S","spike_mutations":"D80Y"}}}]},{"name":"NODE_0000605","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.167232036590576}},"branch_attrs":{"mutations":{"nuc":["G16853T"],"nsp13":["G206V"]},"labels":{"aa":"nsp13: G206V"}},"children":[{"name":"B.1.1.382","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.382"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.60129451751709}},"branch_attrs":{"mutations":{"nuc":["G6368A"],"nsp3":["G1217R"]},"labels":{"aa":"nsp3: G1217R"}}},{"name":"NODE_0000606","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.467953205108643}},"branch_attrs":{"mutations":{"nuc":["C2094T"],"nsp2":["S430L"]},"labels":{"aa":"nsp2: S430L"}},"children":[{"name":"B.1.1.34","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.34"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.467953205108643}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.528","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.528"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.528"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["A1072G","C1449T","A3868T","G9526T","G9756A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21974T","T22912G","C23604G","T26767C","C27297T","A28877T","G28878C","A28911T","C29303T"],"M":["I82T"],"N":["N213I","P344S"],"S":["D138Y","N450K","P681R"],"nsp2":["T215I"],"nsp3":["Q383H"],"nsp4":["M324I","R401H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; N: N213I, P344S; S: D138Y, N450K, P681R; nsp2: T215I; nsp3: Q383H; nsp4: M324I, R401H; nsp6: S106-, G107-, F108-","spike_mutations":"D138Y, N450K, P681R"}}}]}]},{"name":"NODE_0000607","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.25"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.116090297698975}},"branch_attrs":{"mutations":{"nuc":["A1G","A1163T"],"nsp2":["I120F"]},"labels":{"aa":"nsp2: I120F"}},"children":[{"name":"B.1.1.25","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.116090297698975}},"branch_attrs":{"mutations":{}}},{"name":"D.2","node_attrs":{"div":14,"Nextclade_pango":{"value":"D.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20F"},"partiallyAliased":{"value":"B.1.1.25.2"},"clade_nextstrain":{"value":"20F"},"clade_membership":{"value":"20F"},"placement_prior":{"value":-3.0833327770233154}},"branch_attrs":{"mutations":{"nuc":["T7540C","G16647T","C18555T","G22992A","G23401A"],"S":["S477N"]},"labels":{"aa":"S: S477N","clade":"20F","spike_mutations":"S477N"}}},{"name":"NODE_0000608","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.315"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{"nuc":["G1A","T3256C","G14202T","C19718T","C22388T","C26060T","G29227T","C29466T","A29771G"],"N":["A398V"],"ORF3a":["T223I"],"nsp12":["E254D"],"nsp15":["T33I"]},"labels":{"aa":"N: A398V; ORF3a: T223I; nsp12: E254D; nsp15: T33I"}},"children":[{"name":"AD.2","node_attrs":{"div":20,"Nextclade_pango":{"value":"AD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.5890538692474365}},"branch_attrs":{"mutations":{"nuc":["C5622T","G19542T"],"nsp14":["M501I"],"nsp3":["P968L"]},"labels":{"aa":"nsp14: M501I; nsp3: P968L"}}},{"name":"B.1.1.315","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.315"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000609","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.680613994598389}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}},"children":[{"name":"B.1.1.351","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.351"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.351"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C7231T","A9749G","C10776A","A13867C","A15489G","C16658T","G17815A","C19164T","G21724T","C23604A"],"S":["L54F","P681H"],"nsp12":["K143Q"],"nsp13":["T141I","G527R"],"nsp4":["K399E"],"nsp5":["P241H"]},"labels":{"aa":"S: L54F, P681H; nsp12: K143Q; nsp13: T141I, G527R; nsp4: K399E; nsp5: P241H","spike_mutations":"L54F, P681H"}}},{"name":"B.1.1.46","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.46"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["A1C","C1218T","C27110T","T27384C"],"nsp2":["S138L"]},"labels":{"aa":"nsp2: S138L"}}},{"name":"NODE_0000610","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8004047870635986}},"branch_attrs":{"mutations":{"nuc":["G9389A"],"nsp4":["D279N"]},"labels":{"aa":"nsp4: D279N"}},"children":[{"name":"B.1.1.354","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.354"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.354"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.217127323150635}},"branch_attrs":{"mutations":{"nuc":["A1T","G28899T"],"N":["R209I"]},"labels":{"aa":"N: R209I"}}},{"name":"B.1.1.526","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.526"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.526"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-8.332109451293945}},"branch_attrs":{"mutations":{"nuc":["G4510T","C9611T","G12167T","G14622A","C23604A","T24811C","G25250T","G25906T","G28077T","C29659T"],"ORF3a":["G172C"],"ORF8":["V62L"],"S":["P681H","V1230L"],"nsp4":["L353F"],"nsp8":["V26F"]},"labels":{"aa":"ORF3a: G172C; ORF8: V62L; S: P681H, V1230L; nsp4: L353F; nsp8: V26F","spike_mutations":"P681H, V1230L"}}}]}]},{"name":"NODE_0000611","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.33"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8493027687072754}},"branch_attrs":{"mutations":{"nuc":["T27299C","T29148C"],"N":["I292T"],"ORF6":["I33T"]},"labels":{"aa":"N: I292T; ORF6: I33T"}},"children":[{"name":"B.1.1.33","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8493027687072754}},"branch_attrs":{"mutations":{}}},{"name":"N.6","node_attrs":{"div":11,"Nextclade_pango":{"value":"N.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.6"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.92036771774292}},"branch_attrs":{"mutations":{"nuc":["C5365T","G8137T"]}}},{"name":"N.3","node_attrs":{"div":10,"Nextclade_pango":{"value":"N.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.329464435577393}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"N.4","node_attrs":{"div":11,"Nextclade_pango":{"value":"N.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.656524181365967}},"branch_attrs":{"mutations":{"nuc":["A1C","A2475G"],"nsp2":["K557R"]},"labels":{"aa":"nsp2: K557R"}}},{"name":"N.5","node_attrs":{"div":14,"Nextclade_pango":{"value":"N.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A298G","C17274T","A22803G","C25904T","G29134A"],"ORF3a":["S171L"],"S":["Q414R"]},"labels":{"aa":"ORF3a: S171L; S: Q414R","spike_mutations":"Q414R"}}},{"name":"N.9","node_attrs":{"div":16,"Nextclade_pango":{"value":"N.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.9"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["G1264T","C7600T","C7851T","T11078C","G23012A","A27853C","A29882C"],"ORF7b":["E33A"],"S":["E484K"],"nsp3":["A1711V"],"nsp6":["F36L"]},"labels":{"aa":"ORF7b: E33A; S: E484K; nsp3: A1711V; nsp6: F36L","spike_mutations":"E484K"}}}]},{"name":"NODE_0000612","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.592955112457275}},"branch_attrs":{"mutations":{"nuc":["G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.1.523","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.1.523"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.523"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["A1087G","A1610G","A2311G","A2969G","G6609T","C9430T","G10961A","G11222T","C13356T","G14126A","C16466T","G16917A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22035-","A22036-","T22478C","T23042C","A23901C","A24078T","C24642T","C25904T","G25993T","A28273T","G28907T"],"N":["G212C"],"ORF3a":["S171L","V201F"],"S":["E156-","F157-","R158-","F306L","S494P","E780A","D839V","T1027I"],"nsp10":["T111I"],"nsp12":["S229N"],"nsp13":["P77L"],"nsp2":["N269D"],"nsp3":["M84V","R1297I"],"nsp5":["V303I"],"nsp6":["V84F"]},"labels":{"aa":"N: G212C; ORF3a: S171L, V201F; S: E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I; nsp10: T111I; nsp12: S229N; nsp13: P77L; nsp2: N269D; nsp3: M84V, R1297I; nsp5: V303I; nsp6: V84F","spike_mutations":"E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I"}}},{"name":"NODE_0000613","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A1T","C3961T","G7798T","C9072T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G20578A","C21846T","T21992-","A21993-","T21994-","T23287C","C23604A","G23948C","C25276A","A27887-","A27888-","C27889-","G27890-","A27891-","A27892-","C27893-","A27894-","T27895-","G27896-","A27897-","A27898-","A27899-","T27900-","T27901-","G28209T","A28271G","C28896-","T28897-","A28898-","C29769T"],"N":["A208-","R209G"],"ORF8":["E106*"],"S":["T95I","Y144-","P681H","D796H"],"nsp15":["V320M"],"nsp3":["K1693N"],"nsp4":["T173I","A446V"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: A208-, R209G; ORF8: E106*; S: T95I, Y144-, P681H, D796H; nsp15: V320M; nsp3: K1693N; nsp4: T173I, A446V; nsp6: S106-, G107-, F108-","spike_mutations":"T95I, Y144-, P681H, D796H"}},"children":[{"name":"AZ.4","node_attrs":{"div":28,"Nextclade_pango":{"value":"AZ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2416T","G7829C","T7831A","C17569T","T27384C"],"nsp13":["P445S"],"nsp3":["V1704L"]},"labels":{"aa":"nsp13: P445S; nsp3: V1704L"}}},{"name":"NODE_0000614","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C24382T"]}},"children":[{"name":"AZ.5","node_attrs":{"div":30,"Nextclade_pango":{"value":"AZ.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T1G","G3259T","G6463T","T20994C","C29077T","A29879G"],"nsp3":["Q180H"]},"labels":{"aa":"nsp3: Q180H"}}},{"name":"NODE_0000615","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.047244071960449}},"branch_attrs":{"mutations":{"nuc":["C10116T"],"nsp5":["T21I"]},"labels":{"aa":"nsp5: T21I"}},"children":[{"name":"B.1.1.318","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.1.318"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.047244071960449}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000616","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9885480403900146}},"branch_attrs":{"mutations":{"nuc":["A3852T","G21004T"],"nsp16":["A116S"],"nsp3":["E378V"]},"labels":{"aa":"nsp16: A116S; nsp3: E378V"}},"children":[{"name":"AZ.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"AZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.056199073791504}},"branch_attrs":{"mutations":{"nuc":["C10369T","C12400T","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"AZ.3","node_attrs":{"div":28,"Nextclade_pango":{"value":"AZ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["T11850C"],"nsp7":["M3T"]},"labels":{"aa":"nsp7: M3T"}}},{"name":"AZ.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"AZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.071262836456299}},"branch_attrs":{"mutations":{"nuc":["C11345T","C11644T"],"nsp6":["L125F"]},"labels":{"aa":"nsp6: L125F"}}}]}]}]}]}]},{"name":"NODE_0000617","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7063244581222534}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14676T","C15279T","T16176C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23271A","C23604A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF8":["Q27*","R52I","Y73C"],"S":["H69-","V70-","Y144-","N501Y","A570D","P681H","T716I","S982A","D1118H"],"nsp3":["T183I","A890D","I1412T"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: D3L, S235F; ORF8: Q27*, R52I, Y73C; S: H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H; nsp3: T183I, A890D, I1412T; nsp6: S106-, G107-, F108-","clade":"Alpha","spike_mutations":"H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7063244581222534}},"branch_attrs":{"mutations":{}}},{"name":"Q.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"Q.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.1"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.273303270339966}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}}},{"name":"Q.2","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.2"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.956664800643921}},"branch_attrs":{"mutations":{"nuc":["A1752G","C6636T","G22468T","C25626T","C27752T","C28227T"],"ORF7a":["T120I"],"ORF8":["H112Y"],"nsp2":["Y316C"],"nsp3":["T1306I"]},"labels":{"aa":"ORF7a: T120I; ORF8: H112Y; nsp2: Y316C; nsp3: T1306I"}}},{"name":"NODE_0000618","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7612149715423584}},"branch_attrs":{"mutations":{"nuc":["T15096C","A28095T"],"ORF8":["K68*"]},"labels":{"aa":"ORF8: K68*"}},"children":[{"name":"Q.7","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.1349856853485107}},"branch_attrs":{"mutations":{"nuc":["A7069C","A17337G","T18018C","G28884C"],"N":["R204P"],"nsp3":["E1450D"]},"labels":{"aa":"N: R204P; nsp3: E1450D"}}},{"name":"Q.8","node_attrs":{"div":35,"Nextclade_pango":{"value":"Q.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.8"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-4.827495098114014}},"branch_attrs":{"mutations":{"nuc":["C12525T","C19164T","C25096T","A25974C","G29751T"],"ORF3a":["E194D"],"nsp8":["T145I"]},"labels":{"aa":"ORF3a: E194D; nsp8: T145I"}}}]},{"name":"NODE_0000619","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.8349626064300537}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"nsp13":["K460R"]},"labels":{"aa":"nsp13: K460R"}},"children":[{"name":"Q.3","node_attrs":{"div":33,"Nextclade_pango":{"value":"Q.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.3"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.3964552879333496}},"branch_attrs":{"mutations":{"nuc":["G5023A","G10396T","G20962A","G26730C"],"M":["V70L"],"nsp16":["D102N"],"nsp3":["M768I"]},"labels":{"aa":"M: V70L; nsp16: D102N; nsp3: M768I"}}},{"name":"Q.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.4"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.756404399871826}},"branch_attrs":{"mutations":{"nuc":["C335T","A4964G","C7224T","A12162G","A23604G"],"S":["H681R"],"nsp1":["R24C"],"nsp3":["T749A","A1502V"],"nsp8":["Q24R"]},"labels":{"aa":"S: H681R; nsp1: R24C; nsp3: T749A, A1502V; nsp8: Q24R","spike_mutations":"H681R"}}}]}]},{"name":"NODE_0000620","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.3051984310150146}},"branch_attrs":{"mutations":{"nuc":["C313T"]}},"children":[{"name":"B.1.1.181","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.181"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.181"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.882091045379639}},"branch_attrs":{"mutations":{"nuc":["C14724T"]}}},{"name":"B.1.1.214","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.214"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.214"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-2.8961424827575684}},"branch_attrs":{"mutations":{"nuc":["C18167T","G21518T","G28975T"],"N":["M234I"],"nsp14":["P43L"],"nsp16":["R287I"]},"labels":{"aa":"N: M234I; nsp14: P43L; nsp16: R287I"}}},{"name":"B.1.1.305","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.305"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.305"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.704046726226807}},"branch_attrs":{"mutations":{"nuc":["G28396A"],"ORF9b":["G38D"]},"labels":{"aa":"ORF9b: G38D"}}},{"name":"B.1.1.50","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.50"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.179980754852295}},"branch_attrs":{"mutations":{"nuc":["G4510A","G15438T","G25785T"],"ORF3a":["W131C"],"nsp12":["M666I"]},"labels":{"aa":"ORF3a: W131C; nsp12: M666I"}}},{"name":"B.1.1.51","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.51"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.484864234924316}},"branch_attrs":{"mutations":{"nuc":["T10453C","C11195T"],"nsp6":["L75F"]},"labels":{"aa":"nsp6: L75F"}}},{"name":"NODE_0000621","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.787297248840332}},"branch_attrs":{"mutations":{"nuc":["C9286T"]}},"children":[{"name":"B.1.1.284","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.284"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.284"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.2298262119293213}},"branch_attrs":{"mutations":{"nuc":["T4346C","C10376T","C14708T","C28725T","G29692T"],"N":["P151L"],"nsp12":["A423V"],"nsp3":["S543P"],"nsp5":["P108S"]},"labels":{"aa":"N: P151L; nsp12: A423V; nsp3: S543P; nsp5: P108S"}}},{"name":"B.1.1.47","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.47"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.770909309387207}},"branch_attrs":{"mutations":{"nuc":["C19763T"],"nsp15":["T48I"]},"labels":{"aa":"nsp15: T48I"}}}]},{"name":"NODE_0000622","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.306"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0954976081848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C5700A"],"nsp3":["A994D"]},"labels":{"aa":"nsp3: A994D"}},"children":[{"name":"AE.8","node_attrs":{"div":15,"Nextclade_pango":{"value":"AE.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306.8"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9437592029571533}},"branch_attrs":{"mutations":{"nuc":["C1347T","C1943T","C6031T","T7153C","G13975T"],"nsp12":["G179C"],"nsp2":["P181L","R380C"]},"labels":{"aa":"nsp12: G179C; nsp2: P181L, R380C"}}},{"name":"AE.1","node_attrs":{"div":11,"Nextclade_pango":{"value":"AE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.030422210693359}},"branch_attrs":{"mutations":{"nuc":["C25791T"]}}},{"name":"B.1.1.306","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.306"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0954976081848145}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000623","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.4629838466644287}},"branch_attrs":{"mutations":{"nuc":["T19839C"]}},"children":[{"name":"B.1.1.221","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.221"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.221"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.094820976257324}},"branch_attrs":{"mutations":{"nuc":["C21646T","C26846T"]}}},{"name":"B.1.1.220","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.220"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.220"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.65780782699585}},"branch_attrs":{"mutations":{"nuc":["C26681T"]}}},{"name":"B.1.1.291","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.291"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.291"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9559080600738525}},"branch_attrs":{"mutations":{"nuc":["C15933T","C29784T"]}}},{"name":"B.1.1.316","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.316"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.316"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.084707736968994}},"branch_attrs":{"mutations":{"nuc":["C21757T","G23593C","A23756T","G29751T"],"S":["Q677H","T732S"]},"labels":{"aa":"S: Q677H, T732S","spike_mutations":"Q677H, T732S"}}},{"name":"B.1.1.317","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.317"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.317"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8110387325286865}},"branch_attrs":{"mutations":{"nuc":["C28905T"],"N":["A211V"]},"labels":{"aa":"N: A211V"}}},{"name":"B.1.1.459","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.459"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.459"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.982537269592285}},"branch_attrs":{"mutations":{"nuc":["C16971T","A21137G","C24099T"],"S":["A846V"],"nsp16":["K160R"]},"labels":{"aa":"S: A846V; nsp16: K160R","spike_mutations":"A846V"}}},{"name":"B.1.1.464","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.464"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.464"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.04607629776001}},"branch_attrs":{"mutations":{"nuc":["C12025T","C23707T"]}}},{"name":"B.1.1.521","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.521"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.521"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{"nuc":["C4927T","C9693T","C18744T","C23422T"],"nsp4":["A380V"]},"labels":{"aa":"nsp4: A380V"}}},{"name":"R.1","node_attrs":{"div":20,"Nextclade_pango":{"value":"R.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.316.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.117560863494873}},"branch_attrs":{"mutations":{"nuc":["C14340T","G17551A","C18877T","A19167G","C19274A","G22017T","G23012A","G23868T","T26604C","C27213T","C28833T","G29527T"],"M":["F28L"],"N":["S187L","Q418H"],"S":["W152L","E484K","G769V"],"nsp13":["G439R"],"nsp14":["P412H"]},"labels":{"aa":"M: F28L; N: S187L, Q418H; S: W152L, E484K, G769V; nsp13: G439R; nsp14: P412H","spike_mutations":"W152L, E484K, G769V"}}},{"name":"NODE_0000624","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.707209348678589}},"branch_attrs":{"mutations":{"nuc":["A23756G"],"S":["T732A"]},"labels":{"aa":"S: T732A","spike_mutations":"T732A"}},"children":[{"name":"B.1.1.222","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.222"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.222"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.707209348678589}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.418","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.1.418"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.418"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["C1812T","A8072G","A10323G","A21194G","C22480T","G24197T","G24415T","G29751C"],"S":["A879S"],"nsp16":["D179G"],"nsp2":["A336V"],"nsp3":["N1785D"],"nsp5":["K90R"]},"labels":{"aa":"S: A879S; nsp16: D179G; nsp2: A336V; nsp3: N1785D; nsp5: K90R","spike_mutations":"A879S"}}}]}]},{"name":"internal_1fa9","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.250203609466553}},"branch_attrs":{"mutations":{"nuc":["G25088T"],"S":["V1176F"]},"labels":{"aa":"S: V1176F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.28","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.250203609466553}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000626","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.622063636779785}},"branch_attrs":{"mutations":{"nuc":["C12053T","C28253T"],"nsp7":["L71F"]},"labels":{"aa":"nsp7: L71F"}},"children":[{"name":"P.2","node_attrs":{"div":17,"Nextclade_pango":{"value":"P.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.341432809829712}},"branch_attrs":{"mutations":{"nuc":["C100T","T10667G","C11824T","G23012A","G28628T","G28975T","C29754T"],"N":["A119S","M234I"],"S":["E484K"],"nsp5":["L205V"]},"labels":{"aa":"N: A119S, M234I; S: E484K; nsp5: L205V","spike_mutations":"E484K"}}},{"name":"P.6","node_attrs":{"div":23,"Nextclade_pango":{"value":"P.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.6"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C1077T","G2534T","C3736T","C7043T","C8980T","C10029T","A14113G","G21305A","G23587C","G23593T","C24382T","C25665T","G26172T"],"ORF3a":["M260I"],"S":["Q675H","Q677H"],"nsp12":["T225A"],"nsp16":["R216H"],"nsp2":["P91L","V577F"],"nsp3":["P1442S"],"nsp4":["T492I"]},"labels":{"aa":"ORF3a: M260I; S: Q675H, Q677H; nsp12: T225A; nsp16: R216H; nsp2: P91L, V577F; nsp3: P1442S; nsp4: T492I","spike_mutations":"Q675H, Q677H"}}}]},{"name":"NODE_0000627","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-6.379853248596191}},"branch_attrs":{"mutations":{"nuc":["C11450A","A28271C"],"nsp6":["Q160K"]},"labels":{"aa":"nsp6: Q160K"}},"children":[{"name":"P.4","node_attrs":{"div":28,"Nextclade_pango":{"value":"P.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A136G","G1811A","C3177T","C9693T","T9867C","C12008T","C12880T","A15932G","G18756T","C20436T","T22054G","C22079A","T22917G","C23673T","A23720G","G25540A","C28253T","C28932T"],"N":["A220V"],"ORF3a":["V50I"],"S":["N164K","Q173K","L452R","S704L","I720V"],"nsp12":["Y831C"],"nsp2":["A336T"],"nsp3":["P153L"],"nsp4":["A380V","L438P"],"nsp7":["L56F"]},"labels":{"aa":"N: A220V; ORF3a: V50I; S: N164K, Q173K, L452R, S704L, I720V; nsp12: Y831C; nsp2: A336T; nsp3: P153L; nsp4: A380V, L438P; nsp7: L56F","spike_mutations":"N164K, Q173K, L452R, S704L, I720V"}}},{"name":"P.5","node_attrs":{"div":27,"Nextclade_pango":{"value":"P.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5175T","C8950T","C9891T","T10264C","C11152T","C13275T","T14103C","C14571T","T21568A","C21602A","C21721T","C21846T","G23012C","A23064C","C24904T","C28271T","C28531T","G28917T"],"N":["G215V"],"ORF9b":["T83I"],"S":["F2L","Q14K","T95I","E484Q","N501T"],"nsp10":["P84L"],"nsp3":["T819I"],"nsp4":["A446V"]},"labels":{"aa":"N: G215V; ORF9b: T83I; S: F2L, Q14K, T95I, E484Q, N501T; nsp10: P84L; nsp3: T819I; nsp4: A446V","spike_mutations":"F2L, Q14K, T95I, E484Q, N501T"}}}]},{"name":"NODE_0000628","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.552827835083008}},"branch_attrs":{"mutations":{"nuc":["G23012A","A23063T"],"S":["E484K","N501Y"]},"labels":{"aa":"S: E484K, N501Y","spike_mutations":"E484K, N501Y"}},"children":[{"name":"P.3","node_attrs":{"div":26,"Nextclade_pango":{"value":"P.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Theta"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21E (Theta)"},"partiallyAliased":{"value":"B.1.1.28.3"},"clade_nextstrain":{"value":"21E"},"clade_membership":{"value":"21E"},"placement_prior":{"value":-4.4443230628967285}},"branch_attrs":{"mutations":{"nuc":["A4926G","C7564A","T9867C","C11308A","C12049T","C12053T","C17074T","C17339T","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","A22356G","T23341C","C23604A","T24187A","G24836A","C24863T","A27897C","A28271-","C29724T"],"ORF8":["K2Q"],"S":["L141-","G142-","V143-","Y265C","P681H","E1092K","H1101Y"],"nsp13":["L280F","A368V"],"nsp3":["D736G"],"nsp4":["L438P"],"nsp6":["D112E"],"nsp7":["L71F"]},"labels":{"aa":"ORF8: K2Q; S: L141-, G142-, V143-, Y265C, P681H, E1092K, H1101Y; nsp13: L280F, A368V; nsp3: D736G; nsp4: L438P; nsp6: D112E; nsp7: L71F","clade":"Theta","spike_mutations":"L141-, G142-, V143-, Y265C, P681H, E1092K, H1101Y"}}},{"name":"NODE_0000629","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{"nuc":["T733C","C2749T","C3828T","A5648C","A6319G","A6613G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12778T","C13860T","G17259T","C21614T","C21621A","C21638T","G21974T","G22132T","A22812C","C23525T","C24642T","T26149C","G28167A","C28512G","A28877T","G28878C","T29834A"],"N":["P80R"],"ORF3a":["S253P"],"ORF8":["E92K"],"ORF9b":["Q77E"],"S":["L18F","T20N","P26S","D138Y","R190S","K417T","H655Y","T1027I"],"nsp13":["E341D"],"nsp3":["S370L","K977Q"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P80R; ORF3a: S253P; ORF8: E92K; ORF9b: Q77E; S: L18F, T20N, P26S, D138Y, R190S, K417T, H655Y, T1027I; nsp13: E341D; nsp3: S370L, K977Q; nsp6: S106-, G107-, F108-","clade":"Gamma","spike_mutations":"L18F, T20N, P26S, D138Y, R190S, K417T, H655Y, T1027I"}},"children":[{"name":"P.1","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{}}},{"name":"P.1.1","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.7353131771087646}},"branch_attrs":{"mutations":{"nuc":["T13851C"]}}},{"name":"P.1.11","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.11"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.509119987487793}},"branch_attrs":{"mutations":{"nuc":["C7945T","C23604G"],"S":["P681R"]},"labels":{"aa":"S: P681R","spike_mutations":"P681R"}}},{"name":"P.1.14","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.14"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.8808486461639404}},"branch_attrs":{"mutations":{"nuc":["A1G","G9105A","C23380T"],"nsp4":["S184N"]},"labels":{"aa":"nsp4: S184N"}}},{"name":"P.1.12.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"P.1.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.12.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["T3592C","T14769G","G20925A","A22298G","C22413T","T23599A","C25613T","C25844T","T28251G","C28253T"],"ORF3a":["S74F","T151I"],"ORF8":["F120V"],"S":["R246G","T284I","N679K"]},"labels":{"aa":"ORF3a: S74F, T151I; ORF8: F120V; S: R246G, T284I, N679K","spike_mutations":"R246G, T284I, N679K"}}},{"name":"P.1.12","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.12"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{}}},{"name":"P.1.16","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.16"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.7957029342651367}},"branch_attrs":{"mutations":{"nuc":["A25746G"],"ORF3a":["I118M"]},"labels":{"aa":"ORF3a: I118M"}}},{"name":"P.1.15","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.15"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.483485460281372}},"branch_attrs":{"mutations":{"nuc":["A2596G","C18129T"]}}},{"name":"P.1.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.4"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.011761665344238}},"branch_attrs":{"mutations":{"nuc":["T23599G"],"S":["N679K"]},"labels":{"aa":"S: N679K","spike_mutations":"N679K"}}},{"name":"P.1.6","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.6"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10615T","C15714T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}},{"name":"P.1.7.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.7.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T3049C","C10116T","C23604A"],"S":["P681H"],"nsp5":["T21I"]},"labels":{"aa":"S: P681H; nsp5: T21I","spike_mutations":"P681H"}}},{"name":"NODE_0000630","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.10"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.013175010681152}},"branch_attrs":{"mutations":{"nuc":["A1T","C1427T"],"nsp2":["H208Y"]},"labels":{"aa":"nsp2: H208Y"}},"children":[{"name":"P.1.10","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.013175010681152}},"branch_attrs":{"mutations":{}}},{"name":"P.1.10.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.112314701080322}},"branch_attrs":{"mutations":{"nuc":["C2841T","G4300T","C13329T","C26873T"],"nsp10":["T102I"],"nsp3":["A41V"]},"labels":{"aa":"nsp10: T102I; nsp3: A41V"}}}]},{"name":"NODE_0000631","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.17"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A1T","C346T","C28603T"]}},"children":[{"name":"P.1.17","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"P.1.17.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A6704G","G19999T","C21707T"],"S":["H49Y"],"nsp15":["V127F"],"nsp3":["N1329D"]},"labels":{"aa":"S: H49Y; nsp15: V127F; nsp3: N1329D","spike_mutations":"H49Y"}}}]},{"name":"NODE_0000632","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["T592C","A4040G","C9891T"],"nsp3":["I441V"],"nsp4":["A446V"]},"labels":{"aa":"nsp3: I441V; nsp4: A446V"}},"children":[{"name":"P.1.9","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.9"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C6040T","C18647T","G23587C"],"S":["Q675H"],"nsp14":["P203L"]},"labels":{"aa":"S: Q675H; nsp14: P203L","spike_mutations":"Q675H"}}},{"name":"P.1.8","node_attrs":{"div":42,"Nextclade_pango":{"value":"P.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.8"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A20055G","C22971A","C23604G","G25266T","C26039T","G27915T"],"ORF3a":["S216L"],"ORF8":["G8*"],"S":["T470N","P681R","C1235F"]},"labels":{"aa":"ORF3a: S216L; ORF8: G8*; S: T470N, P681R, C1235F","spike_mutations":"T470N, P681R, C1235F"}}}]},{"name":"NODE_0000633","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.685761451721191}},"branch_attrs":{"mutations":{"nuc":["C1912T"]}},"children":[{"name":"P.1.13","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.13"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.1822357177734375}},"branch_attrs":{"mutations":{"nuc":["G10610T"],"nsp5":["V186F"]},"labels":{"aa":"nsp5: V186F"}}},{"name":"P.1.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"P.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.2"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.205961227416992}},"branch_attrs":{"mutations":{"nuc":["A2550G","C5724T","G25855T","C28789T"],"ORF3a":["D155Y"],"nsp2":["D582G"],"nsp3":["T1002I"]},"labels":{"aa":"ORF3a: D155Y; nsp2: D582G; nsp3: T1002I"}}},{"name":"P.1.7","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.7"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.55728816986084}},"branch_attrs":{"mutations":{"nuc":["C16293T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}}]}]}]}]},{"name":"NODE_0000634","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.009088039398193}},"branch_attrs":{"mutations":{"nuc":["C23731T"]}},"children":[{"name":"B.1.1.375","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.1.375"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.375"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.222192764282227}},"branch_attrs":{"mutations":{"nuc":["C2509T","C6781T","C13536T","G17027T","C18747T","G22992A","A23233G","G28048A","G29425T"],"N":["Q384H"],"ORF8":["R52K"],"S":["S477N"],"nsp13":["S264I"]},"labels":{"aa":"N: Q384H; ORF8: R52K; S: S477N; nsp13: S264I","spike_mutations":"S477N"}}},{"name":"NODE_0000635","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.315249443054199}},"branch_attrs":{"mutations":{"nuc":["G10097A"],"nsp5":["G15S"]},"labels":{"aa":"nsp5: G15S"}},"children":[{"name":"B.1.1.369","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.369"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.369"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7882320880889893}},"branch_attrs":{"mutations":{"nuc":["G28580T"],"N":["D103Y"]},"labels":{"aa":"N: D103Y"}}},{"name":"B.1.1.372","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.372"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.372"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.315249443054199}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000636","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-3.7465412616729736}},"branch_attrs":{"mutations":{"nuc":["A1G","C4002T","C13536T"],"nsp3":["T428I"]},"labels":{"aa":"nsp3: T428I","clade":"20D"}},"children":[{"name":"B.1.1.1","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-3.7465412616729736}},"branch_attrs":{"mutations":{}}},{"name":"C.11","node_attrs":{"div":16,"Nextclade_pango":{"value":"C.11"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.11"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["T3G","T8071C","G13201A","C27804T"]}}},{"name":"C.14","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.14"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.14"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.6111273765563965}},"branch_attrs":{"mutations":{"nuc":["G29179T"]}}},{"name":"C.13","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.13"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.13"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.601932048797607}},"branch_attrs":{"mutations":{"nuc":["A21131G"],"nsp16":["Q158R"]},"labels":{"aa":"nsp16: Q158R"}}},{"name":"C.23","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.23"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.903609752655029}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}}},{"name":"C.26","node_attrs":{"div":15,"Nextclade_pango":{"value":"C.26"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.26"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.097338676452637}},"branch_attrs":{"mutations":{"nuc":["G1T","T8278C","G12661A","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-","A29866-","T29867-","G29868-","A29869-","C29870-","A29871-","A29872-","A29873-"]}}},{"name":"C.33","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.33"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.33"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.331241130828857}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}}},{"name":"C.35","node_attrs":{"div":15,"Nextclade_pango":{"value":"C.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.35"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.0756001472473145}},"branch_attrs":{"mutations":{"nuc":["G1T","G5950T","G19732T"],"nsp15":["V38F"],"nsp3":["K1077N"]},"labels":{"aa":"nsp15: V38F; nsp3: K1077N"}}},{"name":"C.29","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.29"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.694921016693115}},"branch_attrs":{"mutations":{"nuc":["T27900C"],"ORF8":["F3L"]},"labels":{"aa":"ORF8: F3L"}}},{"name":"C.32","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.32"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["C14877T"]}}},{"name":"C.4","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.4"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["A4G","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"C.38","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.38"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A4307C","C4763T","C5812T","G6609T","A9103C","C9286T","A11201G","G11417T","C19862T","C21057T","C21727T","T21752A","G23012A","G23948T","T26112C","T26767C","C27925A","C28311T","C28905T","G29405C"],"M":["I82T"],"N":["P13L","A211V","E378Q"],"ORF8":["T11K"],"ORF9b":["P10S"],"S":["W64R","E484K","D796Y"],"nsp15":["A81V"],"nsp3":["K530Q","H682Y","R1297I"],"nsp4":["E183D"],"nsp6":["T77A","V149F"]},"labels":{"aa":"M: I82T; N: P13L, A211V, E378Q; ORF8: T11K; ORF9b: P10S; S: W64R, E484K, D796Y; nsp15: A81V; nsp3: K530Q, H682Y, R1297I; nsp4: E183D; nsp6: T77A, V149F","spike_mutations":"W64R, E484K, D796Y"}}},{"name":"NODE_0000637","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.791935920715332}},"branch_attrs":{"mutations":{"nuc":["C18747T","G29425T"],"N":["Q384H"]},"labels":{"aa":"N: Q384H"}},"children":[{"name":"C.1.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"C.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["G569A","C2485T","C5175T","A7699G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21969T","G22132T","A22206G","C22210T","G22289-","C22290-","T22291-","T22907C","G23012A","A23063T","C23525T","T23599A","C23709T","G26155-","T26156-","T26157-","C28311T","T28516C"],"N":["P13L"],"ORF3a":["V255-"],"ORF9b":["P10S","M78T"],"S":["C136F","R190S","D215G","A243-","Y449H","E484K","N501Y","H655Y","N679K","T716I"],"nsp1":["E102K"],"nsp3":["T819I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P13L; ORF3a: V255-; ORF9b: P10S, M78T; S: C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I; nsp1: E102K; nsp3: T819I; nsp6: S106-, G107-, F108-","spike_mutations":"C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I"}}},{"name":"C.1","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.791935920715332}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000638","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.4457597732543945}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"C.16","node_attrs":{"div":16,"Nextclade_pango":{"value":"C.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.16"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.295919418334961}},"branch_attrs":{"mutations":{"nuc":["G3302A","C9693T","G29422T"],"nsp3":["E195K"],"nsp4":["A380V"]},"labels":{"aa":"nsp3: E195K; nsp4: A380V"}}},{"name":"C.40","node_attrs":{"div":23,"Nextclade_pango":{"value":"C.40"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"S:245-246,ORF3a:258-276"},"designation_date":{"value":"2021-08-27"},"qc.frameShifts.frameShifts":{"value":"S:245-246"},"qc.frameShifts.totalFrameShifts":{"value":1},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.40"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2094T","A3069G","C9891T","A10982G","A12820G","C16466T","G22205C","T22292-","G22299-","A22300-","A22301-","G22302-","T22303-","C23481T","C24138A","A26161-","A28271-","G28917T"],"N":["G215V"],"ORF3a":["N257-"],"S":["D215H","L244-","S247-","S640F","T859N"],"nsp13":["P77L"],"nsp2":["S430L"],"nsp3":["D117G"],"nsp4":["A446V"],"nsp6":["K4E"]},"labels":{"aa":"N: G215V; ORF3a: N257-; S: D215H, L244-, S247-, S640F, T859N; nsp13: P77L; nsp2: S430L; nsp3: D117G; nsp4: A446V; nsp6: K4E","spike_mutations":"D215H, L244-, S247-, S640F, T859N"}}}]},{"name":"NODE_0000639","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.2"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.998661518096924}},"branch_attrs":{"mutations":{"nuc":["T14345C","G18292T"],"nsp12":["L302S"],"nsp14":["A85S"]},"labels":{"aa":"nsp12: L302S; nsp14: A85S"}},"children":[{"name":"C.2.1","node_attrs":{"div":22,"Nextclade_pango":{"value":"C.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["G922T","T8323C","T15437C","C18501T","A23064C","C25624T","C28453T","C29642T"],"ORF10":["Q29*"],"ORF3a":["H78Y"],"ORF9b":["A57V"],"S":["N501T"],"nsp12":["M666T"]},"labels":{"aa":"ORF10: Q29*; ORF3a: H78Y; ORF9b: A57V; S: N501T; nsp12: M666T","spike_mutations":"N501T"}}},{"name":"C.2","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.998661518096924}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9cca","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.36"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.5506086349487305}},"branch_attrs":{"mutations":{"nuc":["G28908T"],"N":["G212V"]},"labels":{"aa":"N: G212V"}},"children":[{"name":"C.36","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.5506086349487305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000641","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.36.3"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G569A","C2841T","G5180A","C7124T","G9203A","G9929A","C11325T","T11337C","C12534T","G16549T","C17766T","C21597T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22016A","A22600C","T22917G","G23593T","G24257T","T26767C","G27882T","A28271-"],"M":["I82T"],"ORF7b":["A43S"],"S":["S12F","H69-","V70-","W152R","R346S","L452R","Q677H","A899S"],"nsp1":["E102K"],"nsp13":["D105Y"],"nsp3":["A41V","D821N","P1469S"],"nsp4":["D217N","D459N"],"nsp6":["S118L","L122S"],"nsp8":["T148I"]},"labels":{"aa":"M: I82T; ORF7b: A43S; S: S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S; nsp1: E102K; nsp13: D105Y; nsp3: A41V, D821N, P1469S; nsp4: D217N, D459N; nsp6: S118L, L122S; nsp8: T148I","spike_mutations":"S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S"}},"children":[{"name":"C.36.3.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"C.36.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C6706T","C17822T","C18189T","G22992A","T24811C","T25729C","A29040G","C29632T"],"N":["K256R"],"ORF3a":["Y113H"],"S":["S477N"],"nsp13":["P529L"]},"labels":{"aa":"N: K256R; ORF3a: Y113H; S: S477N; nsp13: P529L","spike_mutations":"S477N"}}},{"name":"C.36.3","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.36.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000642","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9867C","T22917A","C28253T","A28271C"],"S":["L452Q"],"nsp4":["L438P"]},"labels":{"aa":"S: L452Q; nsp4: L438P","spike_mutations":"L452Q"}},"children":[{"name":"C.39","node_attrs":{"div":31,"Nextclade_pango":{"value":"C.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.39"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2110T","C4763T","C6726T","C7113T","T7348G","C11345T","C14585T","C15194A","C21588T","G22131A","C22997T","T26038C","C26366T","C27128T","A28742G"],"E":["A41V"],"N":["I157V"],"ORF3a":["S216P"],"S":["P9L","R190K","P479S"],"nsp12":["A382V","A585D"],"nsp3":["H682Y","T1336I","T1465I","N1543K"],"nsp6":["L125F"]},"labels":{"aa":"E: A41V; N: I157V; ORF3a: S216P; S: P9L, R190K, P479S; nsp12: A382V, A585D; nsp3: H682Y, T1336I, T1465I, N1543K; nsp6: L125F","spike_mutations":"P9L, R190K, P479S"}}},{"name":"NODE_0000643","node_attrs":{"div":28,"Nextclade_pango":{"value":"C.37"},"clade_who":{"value":"Lambda"},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{"nuc":["C7124T","T7424G","C9857T","C10029T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21786T","C21789T","G22299-","A22300-","A22301-","G22302-","T22303-","T22304-","A22305-","T22306-","T22307-","T22308-","G22309-","A22310-","C22311-","T22312-","C22313-","C22314-","T22315-","G22316-","G22317-","T22318-","G22319-","T23031C","C24138A","C26894T","C28271T","C28311T","G28913T","C29311T"],"N":["P13L","G214C"],"ORF9b":["P10S"],"S":["G75V","T76I","R246-","S247-","Y248-","L249-","T250-","P251-","G252-","D253N","F490S","T859N"],"nsp3":["P1469S","F1569V"],"nsp4":["T492I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P13L, G214C; ORF9b: P10S; S: G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N; nsp3: P1469S, F1569V; nsp4: T492I; nsp6: S106-, G107-, F108-","clade":"Lambda","spike_mutations":"G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N"}},"children":[{"name":"C.37","node_attrs":{"div":28,"Nextclade_pango":{"value":"C.37"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Lambda"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{}}},{"name":"C.37.1","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.37.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Lambda"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37.1"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C20806T","T25760C","A28877T","G28878C"],"ORF3a":["I123T"]},"labels":{"aa":"ORF3a: I123T"}}}]}]}]}]}]},{"name":"NODE_0000644","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.207627296447754}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"nsp4":["T492I"]},"labels":{"aa":"nsp4: T492I"}},"children":[{"name":"AT.1","node_attrs":{"div":32,"Nextclade_pango":{"value":"AT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.370.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1392T","G3281T","A3542G","A5176G","C7005A","T9070C","C9778T","A11451G","T12620A","C16985A","G17562T","G19180T","C20759T","C21588T","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","A22206G","A22296C","G23012A","G23900A","C24370T","T25675A","G26211T","C26568A","G28079T","A28271G"],"M":["L16I"],"ORF3a":["L95M"],"S":["P9L","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","D215G","H245P","E484K","E780K"],"nsp13":["T250N"],"nsp14":["V381L"],"nsp16":["A34V"],"nsp2":["S196L"],"nsp3":["V188F","T275A","T1429N"],"nsp6":["Q160R"],"nsp8":["S177T"]},"labels":{"aa":"M: L16I; ORF3a: L95M; S: P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K; nsp13: T250N; nsp14: V381L; nsp16: A34V; nsp2: S196L; nsp3: V188F, T275A, T1429N; nsp6: Q160R; nsp8: S177T","spike_mutations":"P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K"}}},{"name":"NODE_0000645","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.820734977722168}},"branch_attrs":{"mutations":{"nuc":["C22995A","C23604A"],"S":["T478K","P681H"]},"labels":{"aa":"S: T478K, P681H","spike_mutations":"T478K, P681H"}},"children":[{"name":"B.1.1.519","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.519"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-2.7774267196655273}},"branch_attrs":{"mutations":{"nuc":["C203T","C222T","C3140T","C10954T","A11117G","C12789T","T19839C","C21306T","A23756G","C29197T"],"S":["T732A"],"nsp3":["P141S"],"nsp6":["I49V"],"nsp9":["T35I"]},"labels":{"aa":"S: T732A; nsp3: P141S; nsp6: I49V; nsp9: T35I","spike_mutations":"T732A"}}},{"name":"21M","node_attrs":{"div":40,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-3.696544885635376}},"branch_attrs":{"mutations":{"nuc":["C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","A23013C","A23040G","A23055G","A23063T","T23075C","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C26270T","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371F","S373P","S375F","K417N","N440K","G446S","S477N","E484A","Q493R","Q498R","N501Y","Y505H","H655Y","N679K","N764K","D796Y","Q954H","N969K"],"nsp14":["I42V"],"nsp5":["P132H"],"nsp6":["S106-","G107-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-; ORF9b: P10S, E27-, N28-, A29-; S: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K; nsp14: I42V; nsp5: P132H; nsp6: S106-, G107-","clade":"Omicron","spike_mutations":"A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"NODE_0000647","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.9919705390930176}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"S":["F371L","G496S","T547K","N856K","L981F"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp6":["L105-","I189V"]},"labels":{"aa":"M: D3G; S: F371L, G496S, T547K, N856K, L981F; nsp3: K38R, S1265-, L1266I, A1892T; nsp6: L105-, I189V","clade":"21K","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}},"children":[{"name":"BA.1","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.9919705390930176}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.12","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.12"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7732186317443848}},"branch_attrs":{"mutations":{"nuc":["A5T","G22487C","C28315T"],"ORF9b":["A11V"],"S":["E309Q"]},"labels":{"aa":"ORF9b: A11V; S: E309Q","spike_mutations":"E309Q"}}},{"name":"BA.1.10","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.10"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.681899070739746}},"branch_attrs":{"mutations":{"nuc":["C21T","A17042G"],"nsp13":["Y269C"]},"labels":{"aa":"nsp13: Y269C"}}},{"name":"BA.1.18","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.18"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.3796184062957764}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"nsp3":["T1004I"]},"labels":{"aa":"nsp3: T1004I"}}},{"name":"BA.1.2","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.660147190093994}},"branch_attrs":{"mutations":{"nuc":["C7420T","C11669T"],"nsp6":["R233C"]},"labels":{"aa":"nsp6: R233C"}}},{"name":"BA.1.19","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.19"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.5513505935668945}},"branch_attrs":{"mutations":{"nuc":["A1G","C21034T"],"nsp16":["L126F"]},"labels":{"aa":"nsp16: L126F"}}},{"name":"BA.1.20","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.20"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.5852789878845215}},"branch_attrs":{"mutations":{"nuc":["C11950T","C28472T"],"N":["P67S"]},"labels":{"aa":"N: P67S"}}},{"name":"BA.1.22","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.22"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.7762668132781982}},"branch_attrs":{"mutations":{"nuc":["C21T","G3182A","G5515T"],"nsp3":["E155K"]},"labels":{"aa":"nsp3: E155K"}}},{"name":"BA.1.24","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.24"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.808385372161865}},"branch_attrs":{"mutations":{"nuc":["G22580A","G28378T"],"ORF9b":["R32L"],"S":["E340K"]},"labels":{"aa":"ORF9b: R32L; S: E340K","spike_mutations":"E340K"}}},{"name":"BA.1.3","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.336390972137451}},"branch_attrs":{"mutations":{"nuc":["C21T","A3481G","C8645T"],"nsp4":["H31Y"]},"labels":{"aa":"nsp4: H31Y"}}},{"name":"BA.1.23","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.23"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.952954292297363}},"branch_attrs":{"mutations":{"nuc":["G22599C","T22926G","A22935T","C23013T","C23625T"],"S":["R346T","L455W","K458M","A484V","A688V"]},"labels":{"aa":"S: R346T, L455W, K458M, A484V, A688V","spike_mutations":"R346T, L455W, K458M, A484V, A688V"}}},{"name":"BA.1.4","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.4"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.1539411544799805}},"branch_attrs":{"mutations":{"nuc":["C21T","G23351A"],"S":["V597I"]},"labels":{"aa":"S: V597I","spike_mutations":"V597I"}}},{"name":"BA.1.6","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.6"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.269890308380127}},"branch_attrs":{"mutations":{"nuc":["C21T","C17639T"],"nsp13":["S468L"]},"labels":{"aa":"nsp13: S468L"}}},{"name":"BA.1.5","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.5"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.170540809631348}},"branch_attrs":{"mutations":{"nuc":["C21T","C2091T","C24054T"],"S":["A831V"],"nsp2":["T429I"]},"labels":{"aa":"S: A831V; nsp2: T429I","spike_mutations":"A831V"}}},{"name":"BA.1.8","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.8"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.060263156890869}},"branch_attrs":{"mutations":{"nuc":["A1G","C11455T","C23987T","C29666T"],"ORF10":["L37F"],"S":["P809S"]},"labels":{"aa":"ORF10: L37F; S: P809S","spike_mutations":"P809S"}}},{"name":"BA.1.7","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.7"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.598390579223633}},"branch_attrs":{"mutations":{"nuc":["C21T","C27686T"],"ORF7a":["S98F"]},"labels":{"aa":"ORF7a: S98F"}}},{"name":"BA.1.9","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.9"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.149862766265869}},"branch_attrs":{"mutations":{"nuc":["A1C","C21T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"NODE_0000648","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{"nuc":["G1957T"],"nsp2":["K384N"]},"labels":{"aa":"nsp2: K384N"}},"children":[{"name":"BA.1.13.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.6200740337371826}},"branch_attrs":{"mutations":{"nuc":["A3779G","G19684T"],"nsp15":["V22L"],"nsp3":["N354D"]},"labels":{"aa":"nsp15: V22L; nsp3: N354D"}}},{"name":"BA.1.13","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000649","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.447277069091797}},"branch_attrs":{"mutations":{"nuc":["G27762T"],"ORF7b":["E3*"]},"labels":{"aa":"ORF7b: E3*"}},"children":[{"name":"BA.1.21","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.447277069091797}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.21.1","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.21.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.046947002410889}},"branch_attrs":{"mutations":{"nuc":["T15685A"],"nsp12":["L749M"]},"labels":{"aa":"nsp12: L749M"}}}]},{"name":"NODE_0000650","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{"nuc":["A1C","C12786T"],"nsp9":["T34I"]},"labels":{"aa":"nsp9: T34I"}},"children":[{"name":"BA.1.14","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.14.2","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.14.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.215561866760254}},"branch_attrs":{"mutations":{"nuc":["C1812T"],"nsp2":["A336V"]},"labels":{"aa":"nsp2: A336V"}}},{"name":"BA.1.14.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.468590497970581}},"branch_attrs":{"mutations":{"nuc":["C11109T"],"nsp6":["A46V"]},"labels":{"aa":"nsp6: A46V"}}}]},{"name":"NODE_0000651","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{"nuc":["T3104C","C29632T"],"nsp3":["Y129H"]},"labels":{"aa":"nsp3: Y129H"}},"children":[{"name":"BA.1.16.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.663555145263672}},"branch_attrs":{"mutations":{"nuc":["G9758A","G25455A","T25556G"],"ORF3a":["V55G"],"nsp4":["V402I"]},"labels":{"aa":"ORF3a: V55G; nsp4: V402I"}}},{"name":"BA.1.16","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.16.2","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-5.067102432250977}},"branch_attrs":{"mutations":{"nuc":["C21T","T12436C","A28254G"],"ORF8":["I121V"]},"labels":{"aa":"ORF8: I121V"}}}]},{"name":"NODE_0000652","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{"nuc":["A1C","T10135C","C25708T","A29301G"],"N":["D343G"],"ORF3a":["L106F"]},"labels":{"aa":"N: D343G; ORF3a: L106F"}},"children":[{"name":"BA.1.15","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.15.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.538003921508789}},"branch_attrs":{"mutations":{"nuc":["A24803G"],"S":["I1081V"]},"labels":{"aa":"S: I1081V","spike_mutations":"I1081V"}}},{"name":"BA.1.15.2","node_attrs":{"div":60,"Nextclade_pango":{"value":"BA.1.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.754347085952759}},"branch_attrs":{"mutations":{"nuc":["G22520A","C23444A"],"S":["V320I","Q628K"]},"labels":{"aa":"S: V320I, Q628K","spike_mutations":"V320I, Q628K"}}},{"name":"BA.1.15.3","node_attrs":{"div":61,"Nextclade_pango":{"value":"BA.1.15.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.253582000732422}},"branch_attrs":{"mutations":{"nuc":["C21T","C3602T","C25886T"],"ORF3a":["S165F"],"nsp3":["H295Y"]},"labels":{"aa":"ORF3a: S165F; nsp3: H295Y"}}}]},{"name":"NODE_0000653","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.17"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{"nuc":["A1C","G5924A"],"nsp3":["V1069I"]},"labels":{"aa":"nsp3: V1069I"}},"children":[{"name":"BA.1.17","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.17.1","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.100675106048584}},"branch_attrs":{"mutations":{"nuc":["C21T","C4683T"],"nsp3":["A655V"]},"labels":{"aa":"nsp3: A655V"}}},{"name":"NODE_0000654","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.335338830947876}},"branch_attrs":{"mutations":{"nuc":["C1G","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}},"children":[{"name":"BA.1.17.2","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.335338830947876}},"branch_attrs":{"mutations":{}}},{"name":"BD.1","node_attrs":{"div":61,"Nextclade_pango":{"value":"BD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4503445625305176}},"branch_attrs":{"mutations":{"nuc":["C21T","C3241T","C23444A"],"S":["Q628K"]},"labels":{"aa":"S: Q628K","spike_mutations":"Q628K"}}}]}]},{"name":"NODE_0000655","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4240970611572266}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}},"children":[{"name":"BA.1.1","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4240970611572266}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.1.3","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["C4582T","C23934T","A28416G"],"N":["N48S"],"ORF9b":["I45V"],"S":["T791I"]},"labels":{"aa":"N: N48S; ORF9b: I45V; S: T791I","spike_mutations":"T791I"}}},{"name":"BA.1.1.4","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.4"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7377076148986816}},"branch_attrs":{"mutations":{"nuc":["C21T","G16744A","T25711C","C29754T"],"ORF3a":["Y107H"],"nsp13":["G170S"]},"labels":{"aa":"ORF3a: Y107H; nsp13: G170S"}}},{"name":"NODE_0000656","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.674670934677124}},"branch_attrs":{"mutations":{"nuc":["A1T","A16064G"],"nsp12":["Q875R"]},"labels":{"aa":"nsp12: Q875R"}},"children":[{"name":"BA.1.1.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.674670934677124}},"branch_attrs":{"mutations":{}}},{"name":"BC.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.36091685295105}},"branch_attrs":{"mutations":{"nuc":["C5833T","A22259G"],"S":["I233V"]},"labels":{"aa":"S: I233V","spike_mutations":"I233V"}}},{"name":"BC.2","node_attrs":{"div":60,"Nextclade_pango":{"value":"BC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.884258270263672}},"branch_attrs":{"mutations":{"nuc":["C21T","C13862T","G19348A"],"nsp12":["T141I"],"nsp14":["V437I"]},"labels":{"aa":"nsp12: T141I; nsp14: V437I"}}}]},{"name":"NODE_0000657","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.3621491193771362}},"branch_attrs":{"mutations":{"nuc":["C2470T"]}},"children":[{"name":"BA.1.1.10","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.10"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.4704771041870117}},"branch_attrs":{"mutations":{"nuc":["C21T","C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}}},{"name":"BA.1.1.11","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.11"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.2315807342529297}},"branch_attrs":{"mutations":{"nuc":["G2354A"],"nsp2":["G517R"]},"labels":{"aa":"nsp2: G517R"}}},{"name":"BA.1.1.12","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.12"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.3868720531463623}},"branch_attrs":{"mutations":{"nuc":["C21T","C2942A"],"nsp3":["L75M"]},"labels":{"aa":"nsp3: L75M"}}},{"name":"BA.1.1.14","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.8932130336761475}},"branch_attrs":{"mutations":{"nuc":["A14107G"],"nsp12":["I223V"]},"labels":{"aa":"nsp12: I223V"}}},{"name":"BA.1.1.13","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.139564037322998}},"branch_attrs":{"mutations":{"nuc":["C21T","C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"BA.1.1.16","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.8349038362503052}},"branch_attrs":{"mutations":{"nuc":["A1C","C21595T","C27509G"],"ORF7a":["T39R"]},"labels":{"aa":"ORF7a: T39R"}}},{"name":"BA.1.1.15","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.933518171310425}},"branch_attrs":{"mutations":{"nuc":["G13570A","G29755C"],"nsp12":["G44S"]},"labels":{"aa":"nsp12: G44S"}}},{"name":"BA.1.1.18","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.18"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.329127311706543}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"nsp3":["A1736V"]},"labels":{"aa":"nsp3: A1736V"}}},{"name":"BA.1.1.17","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.2085862159729}},"branch_attrs":{"mutations":{"nuc":["G1659T","C5183T"],"nsp2":["G285V"],"nsp3":["P822S"]},"labels":{"aa":"nsp2: G285V; nsp3: P822S"}}},{"name":"BA.1.1.2","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.413982391357422}},"branch_attrs":{"mutations":{"nuc":["C10560G"],"nsp5":["T169S"]},"labels":{"aa":"nsp5: T169S"}}},{"name":"BA.1.1.5","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.5"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.915313482284546}},"branch_attrs":{"mutations":{"nuc":["C21T","A2589G","C26996T"],"nsp2":["E595G"]},"labels":{"aa":"nsp2: E595G"}}},{"name":"BA.1.1.9","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.9"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.4199085235595703}},"branch_attrs":{"mutations":{"nuc":["C13421T"],"nsp10":["L133F"]},"labels":{"aa":"nsp10: L133F"}}},{"name":"BA.1.1.6","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.6"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.071193695068359}},"branch_attrs":{"mutations":{"nuc":["C21T","C5144T","C28757T"],"N":["P162S"]},"labels":{"aa":"N: P162S"}}},{"name":"BA.1.1.7","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.7"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.486417770385742}},"branch_attrs":{"mutations":{"nuc":["C2453T"],"nsp2":["L550F"]},"labels":{"aa":"nsp2: L550F"}}},{"name":"BA.1.1.8","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.8"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.9190704822540283}},"branch_attrs":{"mutations":{"nuc":["C1766A"],"nsp2":["Q321K"]},"labels":{"aa":"nsp2: Q321K"}}}]}]}]},{"name":"internal_a01b","node_attrs":{"div":51,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.760036468505859}},"branch_attrs":{"mutations":{"nuc":["T670G","G4184A","C4321T","C9534T","G10447A","T11294-","T11295-","T11296-","C12880T","C15714T","G22775A","C26060T","C26858T","A29510C","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["S413R"],"ORF3a":["T223I"],"S":["D405N"],"nsp1":["S135R"],"nsp3":["G489S"],"nsp4":["T327I"],"nsp6":["F108-"]},"labels":{"aa":"N: S413R; ORF3a: T223I; S: D405N; nsp1: S135R; nsp3: G489S; nsp4: T327I; nsp6: F108-","spike_mutations":"D405N"}},"children":[{"name":"internal_8b65","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"nsp6":["A88V"]},"labels":{"aa":"nsp6: A88V"}},"children":[{"name":"BA.3","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":44},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"BA.3.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3.1"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3791A","C3792A","A22812C"],"S":["N417T"],"nsp3":["A358N"]},"labels":{"aa":"S: N417T; nsp3: A358N","spike_mutations":"N417T"}}}]},{"name":"internal_16e4","node_attrs":{"div":70,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.930835485458374}},"branch_attrs":{"mutations":{"nuc":["C2790T","C9344T","A9424G","C10198T","C17410T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21762C","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","T21846C","-21987A","-21988T","-21989G","-21990T","-21991T","-21992T","-21993A","-21994T","-21995T","-22194A","-22195T","-22196T","T22200G","A22688G","A22786C","A22898G","C25000T","C25584T","G27382C","A27383T","T27384C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-"],"ORF6":["D61L"],"S":["T19I","L24-","P25-","P26-","A27S","V67A","-69H","-70V","I95T","-142D","-143V","-144Y","D145Y","-211N","I212L","V213G","T376A","R408S","S446G"],"nsp13":["R392C"],"nsp15":["T112I"],"nsp3":["T24I"],"nsp4":["L264F"]},"labels":{"aa":"ORF6: D61L; S: T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G; nsp13: R392C; nsp15: T112I; nsp3: T24I; nsp4: L264F","clade":"21L","spike_mutations":"T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G"}},"children":[{"name":"BA.2","node_attrs":{"div":70,"Nextclade_pango":{"value":"BA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.930835485458374}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.16","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.223683834075928}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"nsp1":["V84-","M85-"]},"labels":{"aa":"N: T296I; nsp1: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.15"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.828917503356934}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"S":["W64L"],"nsp4":["T387I"]},"labels":{"aa":"S: W64L; nsp4: T387I","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.19"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.502110004425049}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"nsp2":["T153M"]},"labels":{"aa":"nsp2: T153M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.87"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":129,"Nextclade_pango":{"value":"BA.2.87.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8217399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":41},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6657453429914796"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"],"nsp1":["Q15R","M85-","E93K"],"nsp12":["G671S","L829F"],"nsp13":["Q470K"],"nsp14":["L442S"],"nsp3":["E545D","S554A","P822L","A1526V","S1682F"],"nsp4":["T495A"],"nsp7":["L56F"],"nsp9":["K36Q","P71S"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G; nsp1: Q15R, M85-, E93K; nsp12: G671S, L829F; nsp13: Q470K; nsp14: L442S; nsp3: E545D, S554A, P822L, A1526V, S1682F; nsp4: T495A; nsp7: L56F; nsp9: K36Q, P71S","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"NODE_0000662","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-1.482762336730957}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"nsp4":["L438F"]},"labels":{"aa":"nsp4: L438F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.958613395690918}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}}},{"name":"BA.2.11","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04096000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"S":["L452R"],"nsp3":["S1701P"]},"labels":{"aa":"S: L452R; nsp3: S1701P","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.18"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.0617408752441406}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9340405464172363}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.03172000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.01261797446067892"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.24"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.043281078338623}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.26"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5770962238311768}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"nsp2":["L400F"],"nsp4":["T62I"]},"labels":{"aa":"nsp2: L400F; nsp4: T62I"}}},{"name":"BA.2.28","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.28"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.954390048980713}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF3a":["D22G"],"nsp3":["R1297S"],"nsp4":["T269I"]},"labels":{"aa":"ORF3a: D22G; nsp3: R1297S; nsp4: T269I"}}},{"name":"BA.2.27","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.27"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9474265575408936}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"nsp3":["M265I"]},"labels":{"aa":"nsp3: M265I"}}},{"name":"BA.2.29","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.29"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2460474967956543}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"nsp2":["A403T"]},"labels":{"aa":"nsp2: A403T"}}},{"name":"BA.2.30","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.30"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.186188220977783}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF3a":["E239D"],"nsp3":["H295Y"]},"labels":{"aa":"ORF3a: E239D; nsp3: H295Y"}}},{"name":"BA.2.32","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.32"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.723731756210327}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.4","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7230255603790283}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.39","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.39"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"S":["L858I"],"nsp12":["E744D"],"nsp15":["V186F","S243G"]},"labels":{"aa":"S: L858I; nsp12: E744D; nsp15: V186F, S243G","spike_mutations":"L858I"}}},{"name":"BA.2.41","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.41"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7298529148101807}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.42","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.42"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11284999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.43"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.411208152770996}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"S":["F371Y","E1202Q"],"nsp2":["Q588R"]},"labels":{"aa":"S: F371Y, E1202Q; nsp2: Q588R","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.46","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.46"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.784235954284668}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.5","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5876340866088867}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"nsp3":["P200S"]},"labels":{"aa":"nsp3: P200S"}}},{"name":"BA.2.48","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.48"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7899765968322754}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"S":["Y248S"],"nsp3":["T504I"]},"labels":{"aa":"S: Y248S; nsp3: T504I","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.50"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.211312770843506}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.54","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.54"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.137404441833496}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.55","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.55"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.214793682098389}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.58","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.58"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0507121086120605}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.61","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.61"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.497011184692383}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.59","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.59"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.60070276260376}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.60","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.60"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"S":["V1129I","P1162S"],"nsp2":["T371S"],"nsp3":["P679S"]},"labels":{"aa":"S: V1129I, P1162S; nsp2: T371S; nsp3: P679S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.62","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.62"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9947850704193115}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.64","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.64"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.5229573249816895}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"nsp6":["L98F"]},"labels":{"aa":"nsp6: L98F"}}},{"name":"BA.2.65","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.65"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.8447983264923096}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.63","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.63"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.1785149574279785}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"nsp14":["R212K"],"nsp3":["S126L"]},"labels":{"aa":"nsp14: R212K; nsp3: S126L"}}},{"name":"BA.2.70","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.70"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.472323894500732}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"nsp2":["I21V"],"nsp3":["K837N"],"nsp4":["A92T"]},"labels":{"aa":"nsp2: I21V; nsp3: K837N; nsp4: A92T"}}},{"name":"BA.2.77","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.2.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9213199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3221048136122174"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.77"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.605336666107178}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"],"nsp5":["T93I"]},"labels":{"aa":"E: L21F; M: S4F; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H; nsp5: T93I","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.82","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.82"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.82"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.216998100280762}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"S":["I68T","R346T"],"nsp10":["T58I"],"nsp8":["A63T"]},"labels":{"aa":"S: I68T, R346T; nsp10: T58I; nsp8: A63T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.8","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.326139211654663}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.83"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.12534"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.22071783986880583"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.83"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"],"nsp10":["T58I"],"nsp3":["L1328F","T1356A"],"nsp5":["P96S"]},"labels":{"aa":"E: V58L; N: K65R; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L; nsp10: T58I; nsp3: L1328F, T1356A; nsp5: P96S","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.85"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.85"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.299220561981201}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000663","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"S":["I1221T"],"nsp3":["T725I"],"nsp8":["T145I"]},"labels":{"aa":"S: I1221T; nsp3: T725I; nsp8: T145I","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000664","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.123868942260742}},"branch_attrs":{"mutations":{"nuc":["G670T"],"nsp1":["R135S"]},"labels":{"aa":"nsp1: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.123868942260742}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF9b":["N36Y"],"nsp3":["S1717L"]},"labels":{"aa":"N: Q39L; ORF9b: N36Y; nsp3: S1717L"}}}]},{"name":"internal_04a9","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"nsp7":["D77N"]},"labels":{"aa":"nsp7: D77N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.867143630981445}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000666","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.892359972000122}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.33"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.086283206939697}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"nsp3":["P395L"]},"labels":{"aa":"nsp3: P395L"}}},{"name":"BA.2.35","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04096000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.35"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.5697021484375}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.795884847640991}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"nsp15":["Q19H"]},"labels":{"aa":"nsp15: Q19H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.795884847640991}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.40.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.748093843460083}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000668","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.964897632598877}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.964897632598877}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.56.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.696688652038574}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"NODE_0000669","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.636354446411133}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"nsp13":["S36P"]},"labels":{"aa":"nsp13: S36P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.636354446411133}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.3","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.07940673828125}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.2","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.684506416320801}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.4","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.2.10.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.73328"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3166622371297313"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.095335483551025}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"],"nsp12":["G671S"]},"labels":{"aa":"ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L; nsp12: G671S","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.472019672393799}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.472019672393799}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.09519000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6181860283242497"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"],"nsp1":["K47R"],"nsp12":["G671S"]},"labels":{"aa":"M: D3Y; N: T282I; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I; nsp1: K47R; nsp12: G671S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000671","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-1.6233329772949219}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.14"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6388018131256104}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.22"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2793381214141846}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"S":["F186S"],"nsp8":["Q24H"]},"labels":{"aa":"S: F186S; nsp8: Q24H","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.34"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.040848731994629}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.36"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.0697343349456787}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.45","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.30756000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.45"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6386520862579346}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.47","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.47"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.130118370056152}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"S":["Y248H","S1261Y"],"nsp2":["L71F"]},"labels":{"aa":"S: Y248H, S1261Y; nsp2: L71F","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.49"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7807657718658447}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.51","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.51"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.694986581802368}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.52"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8800225257873535}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"nsp2":["C475R"]},"labels":{"aa":"nsp2: C475R"}}},{"name":"BA.2.53","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.33552999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.53"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.6","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6629879474639893}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.7","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.356294631958008}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"nsp3":["T1306I"]},"labels":{"aa":"nsp3: T1306I"}}},{"name":"BA.2.69","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.69"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.939220905303955}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"nsp12":["M463L"]},"labels":{"aa":"nsp12: M463L"}}},{"name":"BA.2.72","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.72"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.616490125656128}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.71","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.71"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.660243034362793}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.80","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.80"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10838000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.31190394480802347"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.80"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.6446309089660645}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"S":["R346T","K356T"],"nsp3":["N22H","R586C"]},"labels":{"aa":"S: R346T, K356T; nsp3: N22H, R586C","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.81"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.81"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.347172260284424}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"S":["L452M"],"nsp12":["I244T"]},"labels":{"aa":"S: L452M; nsp12: I244T","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"nsp2":["I283V"]},"labels":{"aa":"nsp2: I283V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.99613094329834}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"internal_8e5d","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.7391469478607178}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11284999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.44"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.218840599060059}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.024046421051025}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000675","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.191652774810791}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.191652774810791}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.2.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"S":["L452M"],"nsp2":["K142R"]},"labels":{"aa":"N: P67S, S412I; S: L452M; nsp2: K142R","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.352867364883423}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.2","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.620241165161133}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"nsp3":["T1189I"]},"labels":{"aa":"nsp3: T1189I"}}},{"name":"BA.2.9.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.9.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2389769554138184}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"nsp3":["V575A"]},"labels":{"aa":"nsp3: V575A"}}},{"name":"BA.2.9.6","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.9.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.504534721374512}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"S":["L452M"],"nsp2":["V447F"],"nsp3":["P822S"]},"labels":{"aa":"S: L452M; nsp2: V447F; nsp3: P822S","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.2.9.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"],"nsp13":["Q470R"],"nsp3":["H295Y"]},"labels":{"aa":"ORF6: L61P; ORF9b: P51L; S: S730F; nsp13: Q470R; nsp3: H295Y","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000676","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF3a":["L140F"],"nsp4":["A146V"]},"labels":{"aa":"ORF3a: L140F; nsp4: A146V"}},"children":[{"name":"BA.2.3.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.10","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0984086990356445}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.11","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7979328632354736}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"nsp10":["T101I"]},"labels":{"aa":"nsp10: T101I"}}},{"name":"BA.2.3.13","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.3481760025024414}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"nsp5":["L75F"]},"labels":{"aa":"nsp5: L75F"}}},{"name":"BA.2.3.12","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"nsp14":["L157F"],"nsp8":["T145I"]},"labels":{"aa":"nsp14: L157F; nsp8: T145I"}}},{"name":"BA.2.3.17","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.17"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8992514610290527}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"nsp12":["A97V"],"nsp2":["K618N"]},"labels":{"aa":"nsp12: A97V; nsp2: K618N"}}},{"name":"BA.2.3.15","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.15"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8729300498962402}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.19","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.3.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.19"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.702374458312988}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"],"nsp3":["C1421G"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF9b: -27E, -28N, -29A; S: N417T; nsp3: C1421G","spike_mutations":"N417T"}}},{"name":"BA.2.3.14","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.14"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.958418846130371}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"nsp4":["D459A"]},"labels":{"aa":"nsp4: D459A"}}},{"name":"BA.2.3.18","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.18"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.462870121002197}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"nsp13":["R155C","I512S"]},"labels":{"aa":"nsp13: R155C, I512S"}}},{"name":"BA.2.3.5","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3020405769348145}},"branch_attrs":{"mutations":{"nuc":["C936T"],"nsp2":["T44I"]},"labels":{"aa":"nsp2: T44I"}}},{"name":"BA.2.3.7","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"S":["K97E"],"nsp2":["L451F"]},"labels":{"aa":"N: M322I; S: K97E; nsp2: L451F","spike_mutations":"K97E"}}},{"name":"BA.2.3.4","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.8","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"nsp3":["T754I","R883S"]},"labels":{"aa":"nsp3: T754I, R883S"}}},{"name":"BA.2.3.9","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8521339893341064}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9121458530426025}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9121458530426025}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9456899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43687237373984505"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"],"nsp10":["T58I"],"nsp3":["E1271D"],"nsp5":["E47Q"]},"labels":{"aa":"M: S4F; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V; nsp10: T58I; nsp3: E1271D; nsp5: E47Q","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.601434707641602}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06758"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.828201770782471}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"DD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9683399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4733677107846063"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"],"nsp4":["A380V"]},"labels":{"aa":"S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N; nsp4: A380V","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000679","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.17149543762207}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.2.3.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.37526000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.42289430257523936"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.22"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"],"nsp13":["P529L"]},"labels":{"aa":"ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S; nsp13: P529L","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0095014572143555}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000681","node_attrs":{"div":99,"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"],"nsp1":["E10K","L122F"],"nsp13":["T61I"],"nsp2":["E546A"],"nsp3":["H682Y","I896V","K977Q","S1285F"],"nsp6":["L260F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F; nsp1: E10K, L122F; nsp13: T61I; nsp2: E546A; nsp3: H682Y, I896V, K977Q, S1285F; nsp6: L260F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"BS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66194"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-09-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.49181526572268314"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"BS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6589000000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6029918987948071"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"BS.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66821"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4975483601650658"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000682","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"],"nsp13":["T481M"],"nsp2":["T547I"],"nsp3":["I896T","M1351V","T1356I","T1830I"],"nsp7":["Q63R"]},"labels":{"aa":"ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q; nsp13: T481M; nsp2: T547I; nsp3: I896T, M1351V, T1356I, T1830I; nsp7: Q63R","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.3.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8190299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7593324873420084"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000683","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"nsp12":["D155G"]},"labels":{"aa":"nsp12: D155G"}},"children":[{"name":"CM.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91683"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7016283989012374"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":97,"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G354C"],"nsp1":["G30A"]},"labels":{"aa":"nsp1: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"CM.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"CM.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9440299999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8143059671640498"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"S":["A348S"],"nsp2":["E570G"],"nsp3":["T1251I"]},"labels":{"aa":"S: A348S; nsp2: E570G; nsp3: T1251I","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.99403"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7255583352017505"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000687","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"CM.8.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"CM.8.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF10":["A28V"],"nsp14":["N266D"]},"labels":{"aa":"ORF10: A28V; nsp14: N266D"}}},{"name":"NODE_0000688","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":104,"Nextclade_pango":{"value":"CM.8.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000689","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"S":["K147N"],"nsp13":["A52V"]},"labels":{"aa":"S: K147N; nsp13: A52V","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.28625999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0761544902802131"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"NODE_0000690","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35566999999999993"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0179803928276123"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"CM.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"S":["G485D"],"nsp6":["F184V"]},"labels":{"aa":"S: G485D; nsp6: F184V","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"nsp3":["S1285F"]},"labels":{"aa":"nsp3: S1285F"}},"children":[{"name":"CM.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000692","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"nsp15":["N82S"]},"labels":{"aa":"nsp15: N82S"}}},{"name":"NODE_0000693","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.7.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9729599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9785485534494837"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"S":["R403K"],"nsp1":["L16F","A131T"],"nsp12":["V354L"]},"labels":{"aa":"S: R403K; nsp1: L16F, A131T; nsp12: V354L","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000694","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.128854513168335}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.17"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.112544536590576}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"nsp3":["G255R"],"nsp4":["D70G"]},"labels":{"aa":"nsp3: G255R; nsp4: D70G"}}},{"name":"BA.2.37","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.37"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.100731372833252}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"nsp3":["R603K"]},"labels":{"aa":"nsp3: R603K"}}},{"name":"BA.2.57","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.57"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.165760517120361}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"nsp3":["Y1102C"]},"labels":{"aa":"nsp3: Y1102C"}}},{"name":"BA.2.66","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.66"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.677023887634277}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF10":["S23F"],"nsp2":["N133K"],"nsp3":["G334D"]},"labels":{"aa":"ORF10: S23F; nsp2: N133K; nsp3: G334D"}}},{"name":"BA.2.68","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.68"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.937255382537842}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"nsp10":["G34R"]},"labels":{"aa":"nsp10: G34R"}}},{"name":"BA.2.74","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21698000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.33134042675697756"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.74"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8886806964874268}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.73","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.73"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0411696434021}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"S":["G257S"],"nsp3":["P1469S"]},"labels":{"aa":"S: G257S; nsp3: P1469S","spike_mutations":"G257S"}}},{"name":"BA.2.78","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.78"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.664361953735352}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF10":["R24L"],"S":["L452M"],"nsp5":["K90R"]},"labels":{"aa":"ORF10: R24L; S: L452M; nsp5: K90R","spike_mutations":"L452M"}}},{"name":"NODE_0000695","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.096076011657715}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.67"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"nsp10":["D64E"]},"labels":{"aa":"nsp10: D64E"}}},{"name":"NODE_0000696","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"S":["Y248S","N450D"],"nsp13":["P53S"]},"labels":{"aa":"S: Y248S, N450D; nsp13: P53S","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.058580000000000014"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.79.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.058580000000000014"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"nsp13":["I493V"],"nsp3":["T1198I"]},"labels":{"aa":"nsp13: I493V; nsp3: T1198I"}}}]}]},{"name":"NODE_0000697","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000698","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"nsp15":["V22L"]},"labels":{"aa":"nsp15: V22L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.76.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"S":["N185H"],"nsp6":["A161T"]},"labels":{"aa":"S: N185H; nsp6: A161T","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.76.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18492"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.2640232066165751"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"S":["R357K"],"nsp3":["G777S"]},"labels":{"aa":"S: R357K; nsp3: G777S","spike_mutations":"R357K"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.4447851181030273}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.4447851181030273}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.38.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.08445999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.07383293656037815"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":82,"Nextclade_pango":{"value":"BH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.11188000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.370455061085298"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.580877304077148}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"S":["Y144-","G446S","L452Q"],"nsp3":["F396I"],"nsp5":["A94G"]},"labels":{"aa":"S: Y144-, G446S, L452Q; nsp3: F396I; nsp5: A94G","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000701","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.987913131713867}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0862932205200195}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000702","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.91279411315918}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.4","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.38.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.449609756469727}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}},{"name":"BA.2.38.2","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.38.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"S":["F157S"],"nsp10":["T102I"],"nsp3":["T725I"],"nsp6":["N156S"]},"labels":{"aa":"S: F157S; nsp10: T102I; nsp3: T725I; nsp6: N156S","spike_mutations":"F157S"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.12.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07350000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.062348652344665065"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"22C","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0579047203063965}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0579047203063965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000705","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-1.8292839527130127}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"nsp12":["A923T"],"nsp3":["N1247D"]},"labels":{"aa":"nsp12: A923T; nsp3: N1247D"}}},{"name":"BG.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.2"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"],"nsp6":["F184V"]},"labels":{"aa":"N: T282I; ORF7b: A15S; ORF8: Q18*; S: V1264L; nsp6: F184V","spike_mutations":"V1264L"}}},{"name":"BG.3","node_attrs":{"div":79,"Nextclade_pango":{"value":"BG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.3"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.567026138305664}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"nsp4":["T204A"]},"labels":{"aa":"nsp4: T204A"}}},{"name":"BG.5","node_attrs":{"div":79,"Nextclade_pango":{"value":"BG.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.5"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"nsp8":["D30G"]},"labels":{"aa":"nsp8: D30G"}}},{"name":"BG.6","node_attrs":{"div":80,"Nextclade_pango":{"value":"BG.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.6"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"S":["E1202Q"],"nsp10":["V13I"]},"labels":{"aa":"S: E1202Q; nsp10: V13I","spike_mutations":"E1202Q"}}},{"name":"BG.4","node_attrs":{"div":82,"Nextclade_pango":{"value":"BG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.4"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"nsp13":["L581F"],"nsp3":["I1460T"]},"labels":{"aa":"N: P162L; nsp13: L581F; nsp3: I1460T"}}},{"name":"BG.7","node_attrs":{"div":84,"Nextclade_pango":{"value":"BG.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.7"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"nsp2":["E546K"],"nsp3":["V202A","F814L","F1503L"]},"labels":{"aa":"nsp2: E546K; nsp3: V202A, F814L, F1503L"}}}]}]}]},{"name":"NODE_0000706","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"],"nsp12":["G671S"],"nsp3":["S403L","P822S"],"nsp8":["N118S"]},"labels":{"aa":"E: T11A; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q; nsp12: G671S; nsp3: S403L, P822S; nsp8: N118S","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.2.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.499693393707275}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"nsp8":["T17A"]},"labels":{"aa":"nsp8: T17A"}}},{"name":"BA.2.75.8","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.75.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04854"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"S":["L452Q"],"nsp12":["K508R"],"nsp2":["V244A"],"nsp3":["R352H"]},"labels":{"aa":"S: L452Q; nsp12: K508R; nsp2: V244A; nsp3: R352H","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.544774532318115}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81858"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.514627933502197}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.472270488739014}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.2.75.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13451"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.472270488739014}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000709","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7472099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7472099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.378986358642578}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.24593"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5588825437629772"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"S":["R346T"],"nsp12":["T20A"]},"labels":{"aa":"S: R346T; nsp12: T20A","spike_mutations":"R346T"}}},{"name":"NODE_0000711","node_attrs":{"div":94,"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9449499999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.12575999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7451886007636047"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"S":["F486S"],"nsp15":["F329L"]},"labels":{"aa":"S: F486S; nsp15: F329L","spike_mutations":"F486S"}}},{"name":"BR.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9449499999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}}]},{"name":"NODE_0000712","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.10514"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5013910005227346"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000713","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"S":["D574V"],"nsp8":["K72R"]},"labels":{"aa":"S: D574V; nsp8: K72R","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03573"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"BR.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03573"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"nsp13":["T599I"],"nsp3":["K1211N"]},"labels":{"aa":"nsp13: T599I; nsp3: K1211N"}}}]}]}]}]},{"name":"NODE_0000714","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000715","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.210728645324707}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"nsp3":["P1867S"]},"labels":{"aa":"nsp3: P1867S"}}},{"name":"BL.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BL.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16854"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF8":["L4F"],"S":["R346S"],"nsp14":["R135I"]},"labels":{"aa":"N: P368S; ORF8: L4F; S: R346S; nsp14: R135I","spike_mutations":"R346S"}}},{"name":"NODE_0000716","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"S":["K182E"],"nsp12":["H613Y"]},"labels":{"aa":"S: K182E; nsp12: H613Y","spike_mutations":"K182E"}}},{"name":"BL.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000717","node_attrs":{"div":90,"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.19193"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"S":["F490L"],"nsp16":["P215L","R216N"]},"labels":{"aa":"S: F490L; nsp16: P215L, R216N","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BL.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.3464399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF7b":["S31P"],"S":["F490V"],"nsp13":["R507K"]},"labels":{"aa":"ORF7b: S31P; S: F490V; nsp13: R507K","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.56756"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6011952983295785"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"BL.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.11979"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5544855553668998"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF10":["A28V"],"S":["V445A"],"nsp3":["L312F"]},"labels":{"aa":"ORF10: A28V; S: V445A; nsp3: L312F","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.681194305419922}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.681194305419922}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":91,"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"S":["N185D","H207R"],"nsp2":["I77V"],"nsp4":["K8R","A149S"]},"labels":{"aa":"S: N185D, H207R; nsp2: I77V; nsp4: K8R, A149S","spike_mutations":"N185D, H207R"}}},{"name":"BY.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_147e","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BY.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41646999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["S494P"],"nsp1":["G101V"],"nsp9":["G38S"]},"labels":{"aa":"S: S494P; nsp1: G101V; nsp9: G38S","spike_mutations":"S494P"}}},{"name":"BY.1.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a555","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF3a":["G44R"],"S":["L452R","T604I"],"nsp3":["S69F","S1206L"]},"labels":{"aa":"ORF3a: G44R; S: L452R, T604I; nsp3: S69F, S1206L","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41646999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.716528415679932}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"CA.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"S":["L452R"],"nsp6":["L207I"]},"labels":{"aa":"S: L452R; nsp6: L207I","spike_mutations":"L452R"}}},{"name":"CA.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"nsp2":["Y16H"]},"labels":{"aa":"nsp2: Y16H"}}},{"name":"CA.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"CA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"S":["S486P"],"nsp2":["G339S"],"nsp3":["E177D","S1571L"]},"labels":{"aa":"S: S486P; nsp2: G339S; nsp3: E177D, S1571L","spike_mutations":"S486P"}}},{"name":"internal_80b8","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2371799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.0969929695129395}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.0969929695129395}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":91,"Nextclade_pango":{"value":"BN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14197"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78438138961792}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"S":["F490S"],"nsp2":["G212D"]},"labels":{"aa":"S: F490S; nsp2: G212D","spike_mutations":"F490S"}}},{"name":"BN.5","node_attrs":{"div":90,"Nextclade_pango":{"value":"BN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"nsp4":["V192M"]},"labels":{"aa":"nsp4: V192M"}}},{"name":"BN.6","node_attrs":{"div":91,"Nextclade_pango":{"value":"BN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"nsp8":["T17A"]},"labels":{"aa":"nsp8: T17A"}}},{"name":"internal_ece3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"S":["N450D"],"nsp16":["T140I"],"nsp2":["G212D","I387V"]},"labels":{"aa":"S: N450D; nsp16: T140I; nsp2: G212D, I387V","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.11385"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5060716304521155"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.653690335850791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"S":["F490S"],"nsp3":["K1042R"],"nsp4":["L15F"]},"labels":{"aa":"S: F490S; nsp3: K1042R; nsp4: L15F","spike_mutations":"F490S"}}}]},{"name":"internal_40f9","node_attrs":{"div":92,"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14197"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"NODE_0000727","node_attrs":{"div":93,"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"S":["L176F","D936H"],"nsp3":["L1328F"]},"labels":{"aa":"S: L176F, D936H; nsp3: L1328F","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.7","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5340599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9193315170816834"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"NODE_0000728","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.2021600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.2021600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000729","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"nsp16":["G39D"],"nsp3":["S1285F"]},"labels":{"aa":"nsp16: G39D; nsp3: S1285F"}},"children":[{"name":"BN.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000730","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"BN.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.31233"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7815531080803261"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}},{"name":"BN.1.5.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1331"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7470314258752732"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]}]},{"name":"NODE_0000731","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"nsp1":["M85-"],"nsp13":["V226L"],"nsp14":["V199M"]},"labels":{"aa":"nsp1: M85-; nsp13: V226L; nsp14: V199M"}}},{"name":"BN.1.4.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"BN.1.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"nsp5":["T24I"]},"labels":{"aa":"nsp5: T24I"}}},{"name":"NODE_0000732","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"nsp12":["T293I"],"nsp5":["V104I"]},"labels":{"aa":"nsp12: T293I; nsp5: V104I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"BN.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"],"nsp9":["T35I"]},"labels":{"aa":"ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I; nsp9: T35I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"nsp3":["P278T"]},"labels":{"aa":"nsp3: P278T"}}},{"name":"BN.1.4.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"S":["Q1113K"],"nsp15":["T48I"],"nsp16":["K160R"]},"labels":{"aa":"M: T30I; S: Q1113K; nsp15: T48I; nsp16: K160R","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000733","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.13617467880249}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.220160961151123}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000734","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.21326"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7326886306518271"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"S":["T470N"],"nsp14":["K147I"]},"labels":{"aa":"S: T470N; nsp14: K147I","spike_mutations":"T470N"}}},{"name":"BN.1.2.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"nsp14":["D222H"]},"labels":{"aa":"nsp14: D222H"}}},{"name":"BN.1.2.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"nsp13":["A403S"]},"labels":{"aa":"nsp13: A403S"}}},{"name":"BN.1.2.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000735","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"nsp14":["I275S"],"nsp3":["Y1102H"]},"labels":{"aa":"nsp14: I275S; nsp3: Y1102H"}}},{"name":"NODE_0000736","node_attrs":{"div":101,"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"S":["R190M"],"nsp13":["T250A"]},"labels":{"aa":"S: R190M; nsp13: T250A","spike_mutations":"R190M"}}},{"name":"FR.1.5","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"nsp1":["V116M"],"nsp3":["S1424F"],"nsp8":["M129T"]},"labels":{"aa":"nsp1: V116M; nsp3: S1424F; nsp8: M129T"}}},{"name":"FR.1.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"FR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF9b":["G31R"],"nsp12":["A526V"],"nsp2":["A26V"]},"labels":{"aa":"N: -31E, G34-; ORF9b: G31R; nsp12: A526V; nsp2: A26V"}}},{"name":"NODE_0000737","node_attrs":{"div":105,"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"nsp2":["L113F"]},"labels":{"aa":"nsp2: L113F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF3a":["T229I"],"nsp6":["M58I"]},"labels":{"aa":"ORF3a: T229I; nsp6: M58I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497981071472168}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"nsp5":["F223L"]},"labels":{"aa":"nsp5: F223L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{}}},{"name":"DS.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"DS.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"DS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF10":["R24C"],"S":["T572I"],"nsp14":["H26Y"]},"labels":{"aa":"ORF10: R24C; S: T572I; nsp14: H26Y","spike_mutations":"T572I"}}},{"name":"DS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"DS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16291"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0513083167390975"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"nsp1":["H110Y"]},"labels":{"aa":"nsp1: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"nsp3":["Q1100R"]},"labels":{"aa":"nsp3: Q1100R"}}},{"name":"BN.1.3.12","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"S":["V445A"],"nsp14":["L259R"]},"labels":{"aa":"S: V445A; nsp14: L259R","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}},{"name":"EJ.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"EJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"nsp10":["T102I"]},"labels":{"aa":"nsp10: T102I"}}}]},{"name":"internal_f14e","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.269749402999878}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":102,"Nextclade_pango":{"value":"BN.1.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"nsp2":["T388I"],"nsp3":["V393F"]},"labels":{"aa":"nsp2: T388I; nsp3: V393F"}}},{"name":"BN.1.3.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.880107879638672}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"nsp3":["T611I"]},"labels":{"aa":"nsp3: T611I"}}}]}]}]}]}]},{"name":"internal_4ad3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"nsp14":["V182I"]},"labels":{"aa":"nsp14: V182I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"nsp14":["P128S"]},"labels":{"aa":"nsp14: P128S"}}},{"name":"BM.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15852"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.03087854385376}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":96,"Nextclade_pango":{"value":"BM.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15852"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"S":["G75V","L455S"],"nsp4":["D38G"]},"labels":{"aa":"N: L113I; S: G75V, L455S; nsp4: D38G","spike_mutations":"G75V, L455S"}}},{"name":"NODE_0000745","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BM.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.26994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5272935807019111"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"S":["L455S"],"nsp3":["L1035F"]},"labels":{"aa":"S: L455S; nsp3: L1035F","spike_mutations":"L455S"}}},{"name":"NODE_0000746","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78817"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}},{"name":"BM.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81858"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000749","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BM.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"S":["T883I","S939F","P1079T"],"nsp1":["R124C"],"nsp2":["S196L"],"nsp4":["F101L"]},"labels":{"aa":"S: T883I, S939F, P1079T; nsp1: R124C; nsp2: S196L; nsp4: F101L","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"BM.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.992039680480957}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.43724"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":95,"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000752","node_attrs":{"div":96,"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"nsp3":["T763A"]},"labels":{"aa":"nsp3: T763A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.87567"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9457248359372292"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"nsp3":["L1791F"]},"labels":{"aa":"nsp3: L1791F"}}}]},{"name":"NODE_0000753","node_attrs":{"div":98,"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"CJ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CJ.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"S":["D936H"],"nsp6":["F216L"]},"labels":{"aa":"S: D936H; nsp6: F216L","spike_mutations":"D936H"}}},{"name":"CJ.1.3.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CJ.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"S":["R214S"],"nsp6":["G9S"]},"labels":{"aa":"S: R214S; nsp6: G9S","spike_mutations":"R214S"}}}]}]}]},{"name":"NODE_0000754","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000755","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"],"ORF10":["A8V"]},"labels":{"aa":"ORF10: A8V"}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"S":["S486P"],"nsp13":["Y224C"],"nsp2":["G334E"]},"labels":{"aa":"S: S486P; nsp13: Y224C; nsp2: G334E","spike_mutations":"S486P"}}},{"name":"CV.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"S":["L452R"],"nsp3":["V732A"]},"labels":{"aa":"S: L452R; nsp3: V732A","spike_mutations":"L452R"}}}]},{"name":"NODE_0000756","node_attrs":{"div":97,"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"S":["K356T","T572I"],"nsp2":["S36Y","D449A"]},"labels":{"aa":"S: K356T, T572I; nsp2: S36Y, D449A","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"BM.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.46466000000000013"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000757","node_attrs":{"div":99,"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"EP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.46466000000000013"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000758","node_attrs":{"div":105,"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"S":["L452R"],"nsp16":["V9I"]},"labels":{"aa":"S: L452R; nsp16: V9I","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"EP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":109,"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF8":["Q18H"],"nsp8":["P178S"]},"labels":{"aa":"ORF8: Q18H; nsp8: P178S"}},"children":[{"name":"EP.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"EP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"EP.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"ORF10":["R24H"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"ORF10: R24H; S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"nsp3":["Q380K"]},"labels":{"aa":"nsp3: Q380K"}},"children":[{"name":"BM.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000763","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.852805137634277}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"nsp16":["Q28R"]},"labels":{"aa":"nsp16: Q28R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0219999999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":94,"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"CH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36891999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7685109779549473"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000766","node_attrs":{"div":95,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CH.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"nsp2":["S358L"]},"labels":{"aa":"nsp2: S358L"}}},{"name":"CH.1.1.7","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"nsp1":["F143C"]},"labels":{"aa":"nsp1: F143C"}}},{"name":"NODE_0000767","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"S":["K187T"],"nsp2":["M404V"],"nsp3":["A256V"]},"labels":{"aa":"N: A155V; S: K187T; nsp2: M404V; nsp3: A256V","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.08511000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7a:59-122"},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.9441222497200389"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF7a":["C58-"],"S":["N481Y"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: C58-; S: N481Y; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000768","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000769","node_attrs":{"div":101,"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"S":["S486P"],"nsp13":["V597L"],"nsp3":["H727Q"]},"labels":{"aa":"S: S486P; nsp13: V597L; nsp3: H727Q","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9334899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9334899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF7a":["H47N"],"S":["G213E"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp12":["T248I"],"nsp4":["I492T"]},"labels":{"aa":"ORF7a: H47N; S: G213E; nsp1: G82-, H83-, V84-, M85V; nsp12: T248I; nsp4: I492T","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000770","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.513967990875244}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"nsp2":["G262S"]},"labels":{"aa":"nsp2: G262S"}}},{"name":"CH.1.1.15","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"S":["T883I"],"nsp3":["Y1028C","G1476S"]},"labels":{"aa":"S: T883I; nsp3: Y1028C, G1476S","spike_mutations":"T883I"}}},{"name":"CH.1.1.24","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.25","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"nsp2":["S150L"],"nsp9":["P57S"]},"labels":{"aa":"nsp2: S150L; nsp9: P57S"}}},{"name":"CH.1.1.29","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"S":["Q613H"],"nsp2":["P191S"]},"labels":{"aa":"S: Q613H; nsp2: P191S","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000771","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"S":["N185D"],"nsp15":["K89R"],"nsp2":["A247V"]},"labels":{"aa":"S: N185D; nsp15: K89R; nsp2: A247V","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"DV.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"internal_ddb1","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"S":["Q613H"],"nsp1":["R24C"]},"labels":{"aa":"S: Q613H; nsp1: R24C","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"nsp2":["E197K"]},"labels":{"aa":"nsp2: E197K"}},"children":[{"name":"DV.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"nsp12":["V848I"]},"labels":{"aa":"nsp12: V848I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"DV.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"nsp13":["T599I"]},"labels":{"aa":"nsp13: T599I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"S":["L858I"],"nsp5":["A285V"]},"labels":{"aa":"S: L858I; nsp5: A285V","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":108,"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF3a":["A72T"],"nsp12":["A529V"]},"labels":{"aa":"ORF3a: A72T; nsp12: A529V"}},"children":[{"name":"DV.7.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"DV.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000779","node_attrs":{"div":110,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"S":["T961M"],"nsp3":["D1764G"],"nsp8":["P10S"]},"labels":{"aa":"S: T961M; nsp3: D1764G; nsp8: P10S","spike_mutations":"T961M"}}},{"name":"NODE_0000780","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":116,"Nextclade_pango":{"value":"DV.7.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":117,"Nextclade_pango":{"value":"DV.7.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"S":["V90I"],"nsp2":["T486N"],"nsp3":["H290Y"]},"labels":{"aa":"S: V90I; nsp2: T486N; nsp3: H290Y","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF10":["M1V"],"nsp9":["A22V"]},"labels":{"aa":"ORF10: M1V; nsp9: A22V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":114,"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"nsp3":["S1428L"]},"labels":{"aa":"nsp3: S1428L"}},"children":[{"name":"JV.2","node_attrs":{"div":118,"Nextclade_pango":{"value":"JV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"S":["V772I"],"nsp2":["A510V"]},"labels":{"aa":"S: V772I; nsp2: A510V","spike_mutations":"V772I"}}},{"name":"JV.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"JV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.9432199999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}}]}]},{"name":"NODE_0000783","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"KG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":119,"Nextclade_pango":{"value":"KG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.9432199999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"S":["H49Y","A264D","G485R"],"nsp1":["S100N"],"nsp3":["D879E"]},"labels":{"aa":"S: H49Y, A264D, G485R; nsp1: S100N; nsp3: D879E","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000784","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"DV.7.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.3","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":112,"Nextclade_pango":{"value":"DV.7.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000785","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF7b":["I26S"],"nsp13":["V169F"]},"labels":{"aa":"ORF7b: I26S; nsp13: V169F"}}},{"name":"CH.1.1.32","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF9b":["Q77K"],"S":["L858I"],"nsp3":["E156A"]},"labels":{"aa":"N: P80Q; ORF9b: Q77K; S: L858I; nsp3: E156A","spike_mutations":"L858I"}}},{"name":"NODE_0000786","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000787","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"nsp3":["A358T"]},"labels":{"aa":"nsp3: A358T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000788","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.320462703704834}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":104,"Nextclade_pango":{"value":"CH.1.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF10":["I4V"],"S":["T299I","R403K","D1165G"],"nsp2":["A518T"]},"labels":{"aa":"ORF10: I4V; S: T299I, R403K, D1165G; nsp2: A518T","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF6":["K23I"],"S":["K679R"],"nsp4":["A87V"]},"labels":{"aa":"ORF6: K23I; S: K679R; nsp4: A87V","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"nsp4":["Y205H"]},"labels":{"aa":"nsp4: Y205H"}}},{"name":"CH.1.1.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"S":["T732I"],"nsp2":["K158R"],"nsp3":["P968L"]},"labels":{"aa":"S: T732I; nsp2: K158R; nsp3: P968L","spike_mutations":"T732I"}}},{"name":"CH.1.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000789","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"S":["L858I"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp2":["A306V"]},"labels":{"aa":"S: L858I; nsp1: G82-, H83-, V84-, M85V; nsp2: A306V","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"nsp8":["Q24R"]},"labels":{"aa":"nsp8: Q24R"}}}]},{"name":"NODE_0000790","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF6":["I26V"],"nsp3":["A386V"]},"labels":{"aa":"ORF6: I26V; nsp3: A386V"}}}]},{"name":"NODE_0000791","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"nsp13":["D101N"],"nsp2":["N413S"],"nsp3":["P679S"],"nsp4":["T28I"]},"labels":{"aa":"nsp13: D101N; nsp2: N413S; nsp3: P679S; nsp4: T28I"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":108,"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp3":["G1447D"]},"labels":{"aa":"ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K; nsp1: G82-, H83-, V84-, M85-, V86-; nsp3: G1447D","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"JP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:62-122"},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"JP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:62-122"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"],"nsp3":["T724I"]},"labels":{"aa":"ORF3a: P274S; ORF6: L61H; S: G1219V; nsp3: T724I","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000794","node_attrs":{"div":102,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"S":["D215G","Q613H"],"nsp6":["L260F"]},"labels":{"aa":"S: D215G, Q613H; nsp6: L260F","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":105,"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"nsp2":["L204F","R370H"]},"labels":{"aa":"nsp2: L204F, R370H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"FK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"nsp3":["T73I"]},"labels":{"aa":"nsp3: T73I"}}},{"name":"FK.1.2.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF3a":["T64N"],"nsp1":["D139N"],"nsp2":["R46K","Q376K"]},"labels":{"aa":"ORF3a: T64N; nsp1: D139N; nsp2: R46K, Q376K"}}}]},{"name":"NODE_0000796","node_attrs":{"div":103,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"S":["G181A"],"nsp6":["M183I"]},"labels":{"aa":"S: G181A; nsp6: M183I","spike_mutations":"G181A"}}}]},{"name":"NODE_0000798","node_attrs":{"div":107,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF9b":["G31R"],"nsp16":["L183I"]},"labels":{"aa":"N: -31E, G34-; ORF9b: G31R; nsp16: L183I"}},"children":[{"name":"FK.1.5","node_attrs":{"div":109,"Nextclade_pango":{"value":"FK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"NODE_0000799","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"nsp3":["A242T"]},"labels":{"aa":"nsp3: A242T"}},"children":[{"name":"FK.1.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"FK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.16085999999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9815994835819151"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"S":["V445A"],"nsp3":["A534V"]},"labels":{"aa":"S: V445A; nsp3: A534V","spike_mutations":"V445A"}}},{"name":"FK.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["T241-","C3874T","G18984A","G26888A"],"nsp14":["M315I"]},"labels":{"aa":"nsp14: M315I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["-241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"FK.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000801","node_attrs":{"div":113,"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"FK.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"JL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000802","node_attrs":{"div":120,"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.651820659637451}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"],"nsp2":["A31D"],"nsp3":["V238L","N1708S","A1892T"],"nsp6":["V24F"],"nsp9":["T35I"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L; nsp2: A31D; nsp3: V238L, N1708S, A1892T; nsp6: V24F; nsp9: T35I","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":120,"Nextclade_pango":{"value":"BA.2.86"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.651820659637451}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":121,"Nextclade_pango":{"value":"BA.2.86.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.6","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}}},{"name":"BA.2.86.5","node_attrs":{"div":125,"Nextclade_pango":{"value":"BA.2.86.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"BA.2.86.4","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"S":["A222V"],"nsp7":["V33A"]},"labels":{"aa":"S: A222V; nsp7: V33A","spike_mutations":"A222V"}}},{"name":"LV.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"LV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T","G14347A"],"nsp12":["D303N"]},"labels":{"aa":"nsp12: D303N"}}},{"name":"LV.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T21C","C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"S":["R346T","L455S","F456L"],"nsp1":["E148G"],"nsp12":["A529V"],"nsp2":["W450C"],"nsp3":["G251R"],"nsp5":["G283D"]},"labels":{"aa":"S: R346T, L455S, F456L; nsp1: E148G; nsp12: A529V; nsp2: W450C; nsp3: G251R; nsp5: G283D","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000803","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"nsp13":["Y421H"]},"labels":{"aa":"nsp13: Y421H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000804","node_attrs":{"div":128,"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":128,"Nextclade_pango":{"value":"MP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"MP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.12555999999999995"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.6738025507980547"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000805","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000806","node_attrs":{"div":126,"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":126,"Nextclade_pango":{"value":"JQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15919"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000807","node_attrs":{"div":130,"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"S":["L455S"],"nsp6":["L142F"]},"labels":{"aa":"S: L455S; nsp6: L142F","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JQ.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"JQ.2.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"S":["T572I"],"nsp12":["Q822H"],"nsp13":["L581F"]},"labels":{"aa":"S: T572I; nsp12: Q822H; nsp13: L581F","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JQ.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF3a":["I123T"],"S":["F456L"],"nsp2":["T85I"]},"labels":{"aa":"ORF3a: I123T; S: F456L; nsp2: T85I","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000808","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.782770156860352}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"nsp3":["K1155R"]},"labels":{"aa":"nsp3: K1155R"}},"children":[{"name":"JN.4","node_attrs":{"div":123,"Nextclade_pango":{"value":"JN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.51897668838501}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000809","node_attrs":{"div":123,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.825653314590454}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"BA.2.86.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.825653314590454}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.12"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"S":["F456V"],"nsp2":["A318G"]},"labels":{"aa":"S: F456V; nsp2: A318G","spike_mutations":"F456V"}}},{"name":"JN.14","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.14"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.16","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.16"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.18","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.18"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.15","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.15"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.19","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.19"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.17","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.17"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.6","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.6"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.9"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.700376033782959}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.8","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.8"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"NODE_0000810","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.11","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000811","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000812","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6465599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000813","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"nsp3":["T1269I"]},"labels":{"aa":"nsp3: T1269I"}},"children":[{"name":"JN.3.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.3","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000814","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"nsp3":["P74S"]},"labels":{"aa":"N: H300Y; nsp3: P74S"}},"children":[{"name":"JN.3.2","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]}]},{"name":"internal_59b29264","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"nsp2":["Y441C"]},"labels":{"aa":"nsp2: Y441C"}},"children":[{"name":"JN.2","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.5","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.2.4","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"NODE_0000816","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"S":["T572I"],"nsp6":["L75F"]},"labels":{"aa":"N: G25C; S: T572I; nsp6: L75F","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"S":["N487D"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"S: N487D; nsp1: G82-, H83-, V84-, M85V","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000817","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.369624137878418}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.10"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.502436637878418}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000818","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.787649631500244}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF7b":["F19L"],"S":["L455S"],"nsp6":["R252K"]},"labels":{"aa":"ORF7b: F19L; S: L455S; nsp6: R252K","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.787649631500244}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.408924102783203}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26806999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.2179484367370605}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.394025802612305}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9045872688293457}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.21","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.875349044799805}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.20","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062768936157227}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.22","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.6741955280303955}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"nsp2":["S325F"]},"labels":{"aa":"nsp2: S325F"}}},{"name":"JN.1.28","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.404186248779297}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}}},{"name":"JN.1.3","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.493562698364258}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.485931396484375}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.403597354888916}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.030079364776611}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.46","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.232482433319092}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"nsp4":["L353F"]},"labels":{"aa":"nsp4: L353F"}}},{"name":"JN.1.45","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.296973705291748}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.5","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.8042540550231934}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"nsp13":["V348T"]},"labels":{"aa":"nsp13: V348T"}}},{"name":"JN.1.52","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.117435932159424}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}}},{"name":"JN.1.61","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93036"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.496607246855186"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.40602445602417}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.62","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.60","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.340050220489502}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.66","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"],"nsp3":["L1328F","T1465I"]},"labels":{"aa":"ORF3a: L106F; S: H445P, F456L, T1117I; nsp3: L1328F, T1465I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.1086554527282715}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"S":["M1229I"],"nsp16":["T91M"]},"labels":{"aa":"S: M1229I; nsp16: T91M","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.971951484680176}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.1086554527282715}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.240773677825928}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"S":["K444R","Y453F"],"nsp2":["A127V"],"nsp3":["P1326L"]},"labels":{"aa":"S: K444R, Y453F; nsp2: A127V; nsp3: P1326L","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.21099"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.240773677825928}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.23.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.21099"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"S":["N137K","V1264L"],"nsp3":["L312F"]},"labels":{"aa":"S: N137K, V1264L; nsp3: L312F","spike_mutations":"N137K, V1264L"}}}]},{"name":"internal_f571b810","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.012888431549072}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.012888431549072}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.24.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3227362632751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.161813735961914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.261450290679932}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"JN.1.32","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.161813735961914}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_613b5275","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.844100475311279}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"nsp14":["R212K"]},"labels":{"aa":"nsp14: R212K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.844100475311279}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.39068078994751}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.39068078994751}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.741299152374268}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.741299152374268}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.44.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.847970962524414}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.473522663116455}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.54.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.05681999999999991"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.532734695870142"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"S":["V407I","F456L"],"nsp3":["D1242N","M1278T"]},"labels":{"aa":"S: V407I, F456L; nsp3: D1242N, M1278T","spike_mutations":"V407I, F456L"}}},{"name":"JN.1.54","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.473522663116455}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.906276226043701}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.56.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7602899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5395016697354735"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"S":["G181R","R346T","F456V","K484E"],"nsp3":["T820I"]},"labels":{"aa":"S: G181R, R346T, F456V, K484E; nsp3: T820I","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.906276226043701}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.803280353546143}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"nsp3":["A386S"]},"labels":{"aa":"nsp3: A386S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.803280353546143}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.59.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":8.507},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"S":["S31-","R190S","R346T"],"nsp3":["I23V"]},"labels":{"aa":"S: S31-, R190S, R346T; nsp3: I23V","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.234124660491943}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.234124660491943}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.492287635803223}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000830","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.16524600982666}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"nsp12":["K91R"]},"labels":{"aa":"nsp12: K91R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.16524600982666}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.63.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.744444847106934}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"nsp3":["D695E","A1711S"]},"labels":{"aa":"nsp3: D695E, A1711S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.0482683181762695}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.0482683181762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.25026273727417}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.25026273727417}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"S":["F456L"],"nsp12":["T248I"]},"labels":{"aa":"S: F456L; nsp12: T248I","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.394768238067627}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"nsp4":["T461A"]},"labels":{"aa":"nsp4: T461A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.394768238067627}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.341370582580566}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.29.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.341370582580566}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF8":["I121-"],"S":["S31P","R346T"],"nsp3":["E1252K"]},"labels":{"aa":"ORF8: I121-; S: S31P, R346T; nsp3: E1252K","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4552714824676514}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.332234859466553}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.332234859466553}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.36.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.063130855560303}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005667686462402}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005667686462402}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.47.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"S":["T572I","R683Q"],"nsp2":["H194Y"]},"labels":{"aa":"S: T572I, R683Q; nsp2: H194Y","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.47.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.993497371673584}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.403688907623291}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.403688907623291}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.081462383270264}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.51.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.081462383270264}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.513101100921631}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"nsp2":["K219R"]},"labels":{"aa":"nsp2: K219R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.513101100921631}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.7709059715271}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.55.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.627852916717529}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"nsp15":["P270H"]},"labels":{"aa":"nsp15: P270H"}}},{"name":"JN.1.55.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.55.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"nsp3":["T199I"]},"labels":{"aa":"nsp3: T199I"}}}]}]},{"name":"NODE_0000842","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.695337772369385}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.695337772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000843","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.67.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"2-3 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.898660898208618}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.898660898208618}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.853456020355225}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF3a":["V80A"],"S":["R346T","F456L"],"nsp16":["L126F"]},"labels":{"aa":"ORF3a: V80A; S: R346T, F456L; nsp16: L126F","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.175326347351074}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.39.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.5633111000061035}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.39.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.965564727783203}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.965564727783203}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.302712917327881}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.439761161804199}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.439761161804199}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"MS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.217731475830078}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp3":["E122G"]},"labels":{"aa":"S: S31-; nsp3: E122G","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.50.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"nsp3":["N722S"]},"labels":{"aa":"nsp3: N722S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.50.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"ME.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.27215999999999985"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.891237735748291}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.891237735748291}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.83420991897583}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.53.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.83420991897583}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000852","node_attrs":{"div":132,"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2595099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF3a":["L85F"],"S":["T572I"],"nsp3":["T1334I"]},"labels":{"aa":"ORF3a: L85F; S: T572I; nsp3: T1334I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.65.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":140,"Nextclade_pango":{"value":"MF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"S":["S60P","W64L"],"nsp15":["S288F"]},"labels":{"aa":"S: S60P, W64L; nsp15: S288F","spike_mutations":"S60P, W64L"}}}]}]},{"name":"NODE_0000855","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24034T","C24370T","A29700G"],"nsp3":["P822L"]},"labels":{"aa":"nsp3: P822L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.28.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000856","node_attrs":{"div":135,"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9318500000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3745641202332524"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000857","node_attrs":{"div":137,"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"S":["F456L"],"nsp14":["R485K"]},"labels":{"aa":"S: F456L; nsp14: R485K","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000858","node_attrs":{"div":138,"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"KW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"LG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_21507594","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.34359073638916}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.34359073638916}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000860","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.548327922821045}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.30.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.548327922821045}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.693402290344238}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":133,"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.124417304992676}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF7b":["L20I"],"nsp3":["I310F","T1465I"]},"labels":{"aa":"ORF7b: L20I; nsp3: I310F, T1465I"}}},{"name":"KU.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KU.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"S":["G213E"],"nsp3":["P1921L"]},"labels":{"aa":"S: G213E; nsp3: P1921L","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9566845893859863}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.104548931121826}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.48.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"nsp2":["A247V"]},"labels":{"aa":"nsp2: A247V"}}},{"name":"NODE_0000865","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF3a":["S60F"],"nsp3":["T943I"]},"labels":{"aa":"ORF3a: S60F; nsp3: T943I"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"LD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"S":["T572I"],"nsp2":["T497I"]},"labels":{"aa":"S: T572I; nsp2: T497I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000867","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.500879764556885}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.500879764556885}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.8.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000868","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.438821315765381}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.6234030723571777}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000869","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.61719274520874}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.61719274520874}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"nsp6":["N205D"]},"labels":{"aa":"nsp6: N205D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77033805847168}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77033805847168}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.424421787261963}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.424421787261963}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.75288200378418}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.045562267303467}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":136,"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":141,"Nextclade_pango":{"value":"LU.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF7b":["F13L"],"S":["Q677P"],"nsp13":["P47T"],"nsp3":["T182I"]},"labels":{"aa":"ORF7b: F13L; S: Q677P; nsp13: P47T; nsp3: T182I","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":137,"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.396651744842529}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":143,"Nextclade_pango":{"value":"LU.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF9b":["L64P"],"S":["S60P","K182N"],"nsp2":["L24F"],"nsp3":["T1036I"]},"labels":{"aa":"ORF9b: L64P; S: S60P, K182N; nsp2: L24F; nsp3: T1036I","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.772427558898926}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.772427558898926}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.49.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.49.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.320776462554932}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_d6241d6f","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.515070915222168}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.49.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"nsp2":["D391A"]},"labels":{"aa":"nsp2: D391A"}}},{"name":"internal_0257fb60","node_attrs":{"div":134,"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"ORF10":["I27K"],"S":["S31F","F456V"]},"labels":{"aa":"ORF10: I27K; S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"nsp2":["E490K"]},"labels":{"aa":"nsp2: E490K"}}},{"name":"NODE_0000878","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000879","node_attrs":{"div":138,"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"nsp2":["T44I"]},"labels":{"aa":"nsp2: T44I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MB.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.30217999999999995"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000880","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.30778169631958}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.30778169631958}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.58.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.408945560455322}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.224411964416504}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.872320652008057}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.872320652008057}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.468550205230713}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"S":["F456L"],"nsp6":["T96K"]},"labels":{"aa":"S: F456L; nsp6: T96K","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"S":["V62F","F456V"],"nsp13":["T216S"],"nsp3":["A1711V"]},"labels":{"aa":"S: V62F, F456V; nsp13: T216S; nsp3: A1711V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.532392978668213}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"nsp3":["N1329S"]},"labels":{"aa":"nsp3: N1329S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.532392978668213}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.342892169952393}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.64.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.342892169952393}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"MD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"S":["F456V"],"nsp4":["T37I"]},"labels":{"aa":"S: F456V; nsp4: T37I","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":131,"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.914387226104736}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"MD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.914387226104736}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"MD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":134,"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3","node_attrs":{"div":134,"Nextclade_pango":{"value":"MD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"MD.3.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MD.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.229282379150391}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005563735961914}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9326608180999756}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.02389"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.131450176239014}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":134,"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KS.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"S":["T22N"],"nsp3":["L1328F"]},"labels":{"aa":"S: T22N; nsp3: L1328F","spike_mutations":"T22N"}}},{"name":"KS.1.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KS.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.097977638244629}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"nsp13":["A296S"]},"labels":{"aa":"nsp13: A296S"}},"children":[{"name":"JN.1.57.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.57.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"S":["S60P"],"nsp6":["I124V"]},"labels":{"aa":"S: S60P; nsp6: I124V","spike_mutations":"S60P"}}},{"name":"JN.1.57","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_dd754174","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"nsp14":["C39F"]},"labels":{"aa":"nsp14: C39F"}}},{"name":"JN.1.7.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08313"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.566636085510254}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6906843185424805}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.1756510734558105}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}}},{"name":"JN.1.7.6","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.7.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"S":["S60P"],"nsp3":["P791S"]},"labels":{"aa":"S: S60P; nsp3: P791S","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"S":["F456L"],"nsp1":["V28I"]},"labels":{"aa":"S: F456L; nsp1: V28I","spike_mutations":"F456L"}}},{"name":"NODE_0000894","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.7.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000895","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":140,"Nextclade_pango":{"value":"MQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF9b":["V96A"],"S":["T678I"],"nsp3":["P74S"]},"labels":{"aa":"ORF9b: V96A; S: T678I; nsp3: P74S","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"nsp5":["H132Y"]},"labels":{"aa":"nsp5: H132Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04395"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"S":["H445P"],"nsp3":["R352C"],"nsp6":["L37F"]},"labels":{"aa":"S: H445P; nsp3: R352C; nsp6: L37F","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":133,"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"LK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{}}},{"name":"LK.2.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95433"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7119815349578857}},"branch_attrs":{"mutations":{"nuc":["C774T"],"nsp1":["T170I"]},"labels":{"aa":"nsp1: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7119815349578857}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.776749610900879}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.743699073791504}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"KQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_3e1a35d0","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.8164443969726562}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.036890983581543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{}}},{"name":"KV.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"KV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"S":["T572I"],"nsp3":["P153L"]},"labels":{"aa":"S: T572I; nsp3: P153L","spike_mutations":"T572I"}}},{"name":"KV.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.782619953155518}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.782619953155518}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.02389"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000904","node_attrs":{"div":131,"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.769268035888672}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.769268035888672}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.145790100097656}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"LE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"S":["K304N"],"nsp12":["T739I"]},"labels":{"aa":"S: K304N; nsp12: T739I","spike_mutations":"K304N"}}},{"name":"NODE_0000905","node_attrs":{"div":137,"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3.1","node_attrs":{"div":143,"Nextclade_pango":{"value":"LE.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}},{"name":"LE.1.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.5280258655548096}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"nsp2":["F319L"]},"labels":{"aa":"nsp2: F319L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.5280258655548096}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.900146961212158}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"S":["H445P","F456L"],"nsp3":["S1265I"]},"labels":{"aa":"S: H445P, F456L; nsp3: S1265I","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000907","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.64257287979126}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.64257287979126}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972496032714844}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972496032714844}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":132,"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.621585369110107}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"nsp13":["V169F"]},"labels":{"aa":"nsp13: V169F"}},"children":[{"name":"KZ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"KZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.621585369110107}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":133,"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KZ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"S":["T572I"],"nsp3":["L728I"]},"labels":{"aa":"S: T572I; nsp3: L728I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000912","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.3227221965789795}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.10","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.885519981384277}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.391621112823486}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.850338935852051}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000913","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"KR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":137,"Nextclade_pango":{"value":"KR.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"nsp2":["L462F"],"nsp3":["T1269I"]},"labels":{"aa":"nsp2: L462F; nsp3: T1269I"}}},{"name":"NODE_0000914","node_attrs":{"div":136,"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"S":["Q218E"],"nsp14":["I15T"]},"labels":{"aa":"S: Q218E; nsp14: I15T","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KR.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"KR.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2408299999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":11.111},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000915","node_attrs":{"div":134,"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.3","node_attrs":{"div":143,"Nextclade_pango":{"value":"KR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"S":["S60P","K304Q"],"nsp2":["L24F","Q275K"],"nsp3":["I1528V"]},"labels":{"aa":"S: S60P, K304Q; nsp2: L24F, Q275K; nsp3: I1528V","spike_mutations":"S60P, K304Q"}}},{"name":"KR.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}}]}]}]}]},{"name":"NODE_0000916","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.056101322174072}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.056101322174072}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6075029373168945}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"S":["T572I"],"nsp4":["A380V"]},"labels":{"aa":"S: T572I; nsp4: A380V","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.143343448638916}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.143343448638916}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":131,"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9964091777801514}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"S":["V1104L"],"nsp3":["A1690D"]},"labels":{"aa":"S: V1104L; nsp3: A1690D","spike_mutations":"V1104L"}}},{"name":"LB.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9964091777801514}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.6","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695721626281738}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"S":["I670M"],"nsp3":["S1699P"]},"labels":{"aa":"S: I670M; nsp3: S1699P","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"S":["L1143F"],"nsp14":["T97I"]},"labels":{"aa":"S: L1143F; nsp14: T97I","spike_mutations":"L1143F"}}},{"name":"LB.1.8","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.729191780090332}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"S":["-31S"],"nsp2":["I605V"]},"labels":{"aa":"S: -31S; nsp2: I605V","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2408299999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000919","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.558164596557617}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"nsp3":["A655V"]},"labels":{"aa":"nsp3: A655V"}},"children":[{"name":"LB.1.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.558164596557617}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LB.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000920","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"nsp15":["G17R"]},"labels":{"aa":"nsp15: G17R"}},"children":[{"name":"LB.1.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.662420749664307}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"S":["F175L"],"nsp3":["I750F"]},"labels":{"aa":"S: F175L; nsp3: I750F","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"nsp3":["L689F"]},"labels":{"aa":"nsp3: L689F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LB.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000922","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"nsp14":["T31I"]},"labels":{"aa":"nsp14: T31I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF7a":["T28I"],"S":["H445P"],"nsp1":["V84-","M85-"]},"labels":{"aa":"N: T379I; ORF7a: T28I; S: H445P; nsp1: V84-, M85-","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.472050666809082}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.925825357437134}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.925825357437134}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.347440719604492}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000925","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.68872594833374}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.16.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.004867076873779}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF7a":["F59K"],"nsp2":["G220S"]},"labels":{"aa":"ORF7a: F59K; nsp2: G220S"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.16.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_dc847259","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.413978576660156}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.413978576660156}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LA.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"]}}},{"name":"LA.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"LA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.04741999999999978"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"S":["T346I"]},"labels":{"aa":"S: T346I","spike_mutations":"T346I"}}}]}]},{"name":"internal_acb00454","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.084030628204346}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.084030628204346}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.0966057777404785}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF3a":["Y184H"],"S":["S31-"],"nsp2":["K67R"]},"labels":{"aa":"ORF3a: Y184H; S: S31-; nsp2: K67R","spike_mutations":"S31-"}}},{"name":"LF.5","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","A22115G","C28660T"],"S":["T33A","N185D"]},"labels":{"aa":"S: T33A, N185D","spike_mutations":"T33A, N185D"}}},{"name":"LF.6","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":143,"Nextclade_pango":{"value":"LF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21767999999999987"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":50.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.817229820305529"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"],"nsp3":["S1717L"]},"labels":{"aa":"ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R; nsp3: S1717L","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"nsp10":["T115I"]},"labels":{"aa":"N: R385K; nsp10: T115I"}},"children":[{"name":"LF.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LF.4.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF8":["Q29*"],"S":["S31-"],"nsp2":["G339S"]},"labels":{"aa":"ORF8: Q29*; S: S31-; nsp2: G339S","spike_mutations":"S31-"}}}]},{"name":"NODE_0000931","node_attrs":{"div":131,"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6508469581604}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":131,"Nextclade_pango":{"value":"LF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6508469581604}},"branch_attrs":{"mutations":{}}},{"name":"LF.9.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.385717391967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"nsp3":["A450T","S1285F"]},"labels":{"aa":"nsp3: A450T, S1285F"}},"children":[{"name":"LF.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF8":["I121-"],"nsp10":["A32V"]},"labels":{"aa":"ORF8: I121-; nsp10: A32V"}},"children":[{"name":"LF.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LF.3.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LF.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}}]}]},{"name":"NODE_0000936","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000937","node_attrs":{"div":136,"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LF.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"nsp14":["Y64H"]},"labels":{"aa":"nsp14: Y64H"}}},{"name":"LF.8.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LF.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"S":["T22N"],"nsp10":["L138F"]},"labels":{"aa":"S: T22N; nsp10: L138F","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.106708526611328}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.106708526611328}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.18.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp15":["S288F"],"nsp2":["A510V"]},"labels":{"aa":"S: S31-; nsp15: S288F; nsp2: A510V","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.95346736907959}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.95346736907959}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"],"nsp3":["E122D","A1766T"]},"labels":{"aa":"S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A; nsp3: E122D, A1766T","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.18.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{}}},{"name":"LH.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"LH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"S":["I197V","P251H"],"nsp3":["E948A"]},"labels":{"aa":"S: I197V, P251H; nsp3: E948A","spike_mutations":"I197V, P251H"}}},{"name":"LH.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.221216201782227}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"S":["K182I"],"nsp2":["G424S"]},"labels":{"aa":"S: K182I; nsp2: G424S","spike_mutations":"K182I"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.8283514976501465}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.8283514976501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":133,"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.243719577789307}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"ORF10":["N36S"],"S":["S31-","R190S"]},"labels":{"aa":"ORF10: N36S; S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"MA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.795657634735107}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":136,"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"MA.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MA.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3926199999999998"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":11.111},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.4456329345703125}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.4456329345703125}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":131,"Nextclade_pango":{"value":"LQ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"nsp3":["T943I"]},"labels":{"aa":"nsp3: T943I"}}},{"name":"internal_7901df09","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.520936012268066}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"S":["N556K"],"nsp2":["T3A"]},"labels":{"aa":"S: N556K; nsp2: T3A","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":132,"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"LQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.721512794494629}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"internal_01daa250","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.106212139129639}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"S":["D80Y","P174S","S689N"],"nsp13":["L428F"]},"labels":{"aa":"S: D80Y, P174S, S689N; nsp13: L428F","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"NODE_0000949","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.172158718109131}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.172158718109131}},"branch_attrs":{"mutations":{}}},{"name":"LY.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"S":["Q183H"],"nsp3":["T1184M"],"nsp4":["A472T"]},"labels":{"aa":"S: Q183H; nsp3: T1184M; nsp4: A472T","spike_mutations":"Q183H"}}},{"name":"LY.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.744548320770264}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"NODE_0000950","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"NODE_0000951","node_attrs":{"div":134,"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G"],"nsp3":["K408E"]},"labels":{"aa":"nsp3: K408E"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LZ.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"2-3 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C29642T"],"ORF10":["Q29*"]},"labels":{"aa":"ORF10: Q29*"}}},{"name":"LZ.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]},{"name":"internal_24bd909c","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C22928T"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.18.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"internal_41eb7227","node_attrs":{"div":138,"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"nsp2":["I560V"]},"labels":{"aa":"N: A152T; nsp2: I560V"}},"children":[{"name":"LZ.1.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"LZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}},{"name":"LZ.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.858034133911133}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.858034133911133}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"S":["F456L"],"nsp3":["T1465I"]},"labels":{"aa":"S: F456L; nsp3: T1465I","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.6","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.04741999999999978"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-6.00890588760376}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"KP.5","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000956","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"internal_181bd2e5","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.27333999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7741516492587035"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"S":["S31-"],"nsp2":["M418V"]},"labels":{"aa":"S: S31-; nsp2: M418V","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.4.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"nsp12":["T141I"]},"labels":{"aa":"nsp12: T141I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.4.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.4.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"S":["G35R"],"nsp2":["G339S"],"nsp3":["I1409V"]},"labels":{"aa":"S: G35R; nsp2: G339S; nsp3: I1409V","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000961","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"S":["K182N"],"nsp15":["L162F"]},"labels":{"aa":"S: K182N; nsp15: L162F","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"S":["T572I","K679N"],"nsp4":["V328I"]},"labels":{"aa":"S: T572I, K679N; nsp4: V328I","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"S":["T572I"],"nsp10":["P86T"],"nsp14":["T378I"]},"labels":{"aa":"S: T572I; nsp10: P86T; nsp14: T378I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"S":["S71Y"],"nsp15":["T325I"]},"labels":{"aa":"S: S71Y; nsp15: T325I","spike_mutations":"S71Y"}}},{"name":"LP.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"S":["K182E"],"nsp12":["R285S"]},"labels":{"aa":"S: K182E; nsp12: R285S","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":139,"Nextclade_pango":{"value":"LP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_bfd296bd","node_attrs":{"div":136,"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000967","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"LP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"internal_55cfa969","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.616637706756592}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"S":["L56V"],"nsp3":["T1275I"]},"labels":{"aa":"S: L56V; nsp3: T1275I","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.14","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.12","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"S":["V1176F"],"nsp2":["E19K"]},"labels":{"aa":"S: V1176F; nsp2: E19K","spike_mutations":"V1176F"}}},{"name":"KP.2.19","node_attrs":{"div":140,"Nextclade_pango":{"value":"KP.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"S":["S31-"],"nsp1":["V28I"]},"labels":{"aa":"S: S31-; nsp1: V28I","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"S":["S60P"],"nsp14":["K147I"]},"labels":{"aa":"S: S60P; nsp14: K147I","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"nsp12":["D445N"]},"labels":{"aa":"nsp12: D445N"}},"children":[{"name":"KP.2.20","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.20.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.096656799316406}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}}]},{"name":"internal_53692388","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000972","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.40119000000000016"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7908990401504723"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.2.3.4","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"NODE_0000973","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"nsp3":["T1303A"]},"labels":{"aa":"nsp3: T1303A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF6":["L16I"],"S":["Q239R"],"nsp2":["I605V"]},"labels":{"aa":"ORF6: L16I; S: Q239R; nsp2: I605V","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000974","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.916172504425049}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21942999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.17","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.16","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.532754898071289}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp6":["V149F"]},"labels":{"aa":"S: S31-; nsp6: V149F","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.321987628936768}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000975","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"KP.3.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"S":["S31F"],"nsp3":["E374K"]},"labels":{"aa":"N: A134V; S: S31F; nsp3: E374K","spike_mutations":"S31F"}}},{"name":"KP.3.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"KP.3.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5554650921238282"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"S":["A435S"],"nsp8":["N192T"]},"labels":{"aa":"S: A435S; nsp8: N192T","spike_mutations":"A435S"}}},{"name":"NODE_0000978","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"nsp3":["I549L"]},"labels":{"aa":"nsp3: I549L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"S":["S31-"],"nsp3":["V418I"]},"labels":{"aa":"S: S31-; nsp3: V418I","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"ML.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"ML.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.4867472648620605}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.350050449371338}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000982","node_attrs":{"div":140,"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"LW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"LW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"S":["T33I"],"nsp4":["P29S"]},"labels":{"aa":"S: T33I; nsp4: P29S","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":142,"Nextclade_pango":{"value":"LW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000983","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.7","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"KP.3.1.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF3a":["I186V"],"S":["N556K"],"nsp3":["Q180H"]},"labels":{"aa":"ORF3a: I186V; S: N556K; nsp3: Q180H","spike_mutations":"N556K"}}},{"name":"NODE_0000984","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"MY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"nsp14":["P151S"]},"labels":{"aa":"nsp14: P151S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"MM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000986","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}},{"name":"MK.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"MK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.3","node_attrs":{"div":143,"Nextclade_pango":{"value":"MK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.11924"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7206397516519647"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"S":["R346T","H445R"],"nsp2":["L113F"],"nsp3":["S454G","T1251N","D1774Y"]},"labels":{"aa":"S: R346T, H445R; nsp2: L113F; nsp3: S454G, T1251N, D1774Y","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"S":["S151I"],"nsp3":["A1311V"]},"labels":{"aa":"S: S151I; nsp3: A1311V","spike_mutations":"S151I"}}},{"name":"NODE_0000988","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp10":["S33C"]},"labels":{"aa":"S: S31-; nsp10: S33C","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.15","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.910944700241089}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.14","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.02898645401001}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.3","node_attrs":{"div":142,"Nextclade_pango":{"value":"MC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.6","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.3801984786987305}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"nsp2":["P589S"],"nsp3":["G1273S"]},"labels":{"aa":"nsp2: P589S; nsp3: G1273S"}}},{"name":"MC.7","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.3172000000000001"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5369762101413171"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-6.544749736785889}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.4","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.9","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.347929000854492}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF3a":["K75N"],"nsp13":["A296S"]},"labels":{"aa":"ORF3a: K75N; nsp13: A296S"}}},{"name":"NODE_0000989","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MC.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000990","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MC.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.050478935241699}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"MC.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":74,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7695722579956055}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000994","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.526405334472656}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.8"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.526405334472656}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000995","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF7b":["L11F"],"nsp1":["K141-","S142-","F143-"]},"labels":{"aa":"ORF7b: L11F; nsp1: K141-, S142-, F143-"}},"children":[{"name":"BA.4","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"nsp3":["H818Q"]},"labels":{"aa":"nsp3: H818Q"}}},{"name":"NODE_0000996","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.9144246578216553}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.222130537033081}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"nsp16":["P236L"]},"labels":{"aa":"nsp16: P236L"}}},{"name":"BA.4.5","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.7"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.027554035186768}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000997","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.7857275009155273}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.7857275009155273}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.9799063205718994}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.2","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"S":["V445A"],"nsp3":["D505G","M1441I"]},"labels":{"aa":"S: V445A; nsp3: D505G, M1441I","spike_mutations":"V445A"}}},{"name":"BA.4.6.3","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.71883"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"S":["Y144-","K444N","N460K"],"nsp3":["G145C"]},"labels":{"aa":"S: Y144-, K444N, N460K; nsp3: G145C","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.4","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000998","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":82,"Nextclade_pango":{"value":"DC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66094"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"internal_813c","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.7295260429382324}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF9b":["P51L"],"nsp2":["R544G"]},"labels":{"aa":"ORF9b: P51L; nsp2: R544G"}}},{"name":"BA.4.1.5","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.4.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"BA.4.1.6","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"nsp10":["T102I"]},"labels":{"aa":"nsp10: T102I"}}},{"name":"BA.4.1.9","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.9"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.8"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8587093353271484}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001000","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"nsp12":["L323F"]},"labels":{"aa":"nsp12: L323F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF7a":["P84L"],"nsp3":["P153S"]},"labels":{"aa":"ORF7a: P84L; nsp3: P153S"}}},{"name":"BA.4.1.7","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.7"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"S":["Q52R"],"nsp14":["D301G"],"nsp3":["D1122G"]},"labels":{"aa":"S: Q52R; nsp14: D301G; nsp3: D1122G","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001001","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.4.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.11"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0001002","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.67074"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5308081831240151"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"CS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5702799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7561969850799493"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"S":["K444R"],"nsp13":["E341D"]},"labels":{"aa":"S: K444R; nsp13: E341D","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0001003","node_attrs":{"div":82,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.162142753601074}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":82,"Nextclade_pango":{"value":"BA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.162142753601074}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39901000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2395057678222656}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"S":["R346I"],"nsp6":["T181I"]},"labels":{"aa":"S: R346I; nsp6: T181I","spike_mutations":"R346I"}}},{"name":"NODE_0001004","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9982612133026123}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"nsp3":["M1278L"]},"labels":{"aa":"nsp3: M1278L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF7a":["H47D"],"nsp1":["E91K"],"nsp2":["T170I"]},"labels":{"aa":"ORF7a: H47D; nsp1: E91K; nsp2: T170I"}}},{"name":"BA.5.8","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"S":["P1162L"],"nsp13":["V348L"],"nsp15":["T325I"]},"labels":{"aa":"S: P1162L; nsp13: V348L; nsp15: T325I","spike_mutations":"P1162L"}}}]},{"name":"NODE_0001005","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9458131790161133}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.243049144744873}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"nsp12":["G671V"]},"labels":{"aa":"nsp12: G671V"}}},{"name":"BA.5.5","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9458131790161133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001006","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.89169979095459}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5131309032440186}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"nsp12":["L323R"],"nsp4":["V403F"]},"labels":{"aa":"nsp12: L323R; nsp4: V403F"}}}]}]},{"name":"NODE_0001007","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0763678550720215}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"nsp13":["A389V"],"nsp16":["T140I"]},"labels":{"aa":"nsp13: A389V; nsp16: T140I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0763678550720215}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001008","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1130268573760986}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"nsp14":["M315I"]},"labels":{"aa":"nsp14: M315I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9632551670074463}},"branch_attrs":{"mutations":{"nuc":["T29597C"],"ORF10":["Y14H"]},"labels":{"aa":"ORF10: Y14H"}}},{"name":"BA.5.6.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5883099999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}},{"name":"BA.5.6.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001009","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001010","node_attrs":{"div":91,"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"S":["N460K"],"nsp2":["V447I"]},"labels":{"aa":"S: N460K; nsp2: V447I","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6570799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"S":["Y144-","R346S"],"nsp3":["I733V"]},"labels":{"aa":"S: Y144-, R346S; nsp3: I733V","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0001011","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BW.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"nsp13":["P78S"]},"labels":{"aa":"nsp13: P78S"}}},{"name":"BW.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"nsp3":["L46F"]},"labels":{"aa":"nsp3: L46F"}}}]}]}]}]},{"name":"NODE_0001012","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.2667036056518555}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"],"ORF10":["L37F"]},"labels":{"aa":"ORF10: L37F"}},"children":[{"name":"BA.5.1","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.2667036056518555}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4272186756134033}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.96599817276001}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"nsp3":["S1578I"]},"labels":{"aa":"nsp3: S1578I"}}},{"name":"BA.5.1.16","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.954094409942627}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF7a":["G26D"],"nsp3":["M84V"]},"labels":{"aa":"ORF7a: G26D; nsp3: M84V"}}},{"name":"BA.5.1.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"nsp3":["I1550T"],"nsp7":["Q63R"]},"labels":{"aa":"N: A211S; nsp3: I1550T; nsp7: Q63R"}}},{"name":"BA.5.1.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2638373374938965}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.17","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7746376991271973}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.24","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3640358448028564}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"nsp13":["V348L"]},"labels":{"aa":"nsp13: V348L"}}},{"name":"BA.5.1.28","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257040023803711}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1503190994262695}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9021759033203125}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"S":["K147-","N148-","P1162S"],"nsp1":["G82-","H83-","V84-","M85-"],"nsp2":["P446L"]},"labels":{"aa":"S: K147-, N148-, P1162S; nsp1: G82-, H83-, V84-, M85-; nsp2: P446L","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"nsp13":["R155L"],"nsp3":["V299I","S692C"]},"labels":{"aa":"nsp13: R155L; nsp3: V299I, S692C"}}},{"name":"BA.5.1.7","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.88628888130188}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"nsp12":["A529V"],"nsp15":["T281I"]},"labels":{"aa":"nsp12: A529V; nsp15: T281I"}}},{"name":"BA.5.1.8","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6331071853637695}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"nsp16":["T151I"],"nsp9":["T21I"]},"labels":{"aa":"nsp16: T151I; nsp9: T21I"}}},{"name":"BA.5.1.5","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1470396518707275}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.6","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.541717767715454}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"nsp3":["V635I"]},"labels":{"aa":"nsp3: V635I"}}},{"name":"NODE_0001013","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF9b":["T60I"],"nsp6":["K270R"]},"labels":{"aa":"ORF9b: T60I; nsp6: K270R"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"BK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"nsp2":["G339S"]},"labels":{"aa":"nsp2: G339S"}}}]},{"name":"internal_6f22","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"nsp5":["H246Y"]},"labels":{"aa":"nsp5: H246Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"DL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0001015","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"nsp13":["S350L"]},"labels":{"aa":"nsp13: S350L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"DH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"S":["Y145-","H146-"],"nsp3":["T1275I","A1381T","S1913G"]},"labels":{"aa":"S: Y145-, H146-; nsp3: T1275I, A1381T, S1913G","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0001016","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"CU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3032753467559814}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF9b":["P51L"],"nsp13":["V247I"],"nsp3":["P874S"]},"labels":{"aa":"ORF9b: P51L; nsp13: V247I; nsp3: P874S"}}},{"name":"BA.5.1.38","node_attrs":{"div":95,"Nextclade_pango":{"value":"BA.5.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"],"nsp16":["A192T"]},"labels":{"aa":"ORF8: S103L; ORF9b: T83I; S: R346T; nsp16: A192T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"nsp3":["I707M"]},"labels":{"aa":"nsp3: I707M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"EB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001019","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF9b":["T95M"],"S":["V1264L"],"nsp12":["G671S"],"nsp3":["T626A"]},"labels":{"aa":"ORF9b: T95M; S: V1264L; nsp12: G671S; nsp3: T626A","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"EQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8467981815338135}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"nsp2":["S122F"]},"labels":{"aa":"nsp2: S122F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8467981815338135}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.115823268890381}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF3a":["R134C"],"S":["G181V","R346T"],"nsp12":["M629T"],"nsp2":["A488T"]},"labels":{"aa":"ORF3a: R134C; S: G181V, R346T; nsp12: M629T; nsp2: A488T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"DE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0001022","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4300601482391357}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"nsp14":["D379N"]},"labels":{"aa":"nsp14: D379N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF7a":["L30H"],"S":["R346T"],"nsp12":["T319I"],"nsp13":["A553S"],"nsp2":["H237Y"]},"labels":{"aa":"ORF7a: L30H; S: R346T; nsp12: T319I; nsp13: A553S; nsp2: H237Y","spike_mutations":"R346T"}}},{"name":"NODE_0001023","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.069719314575195}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"nsp12":["G671S"]},"labels":{"aa":"nsp12: G671S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.069719314575195}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"BT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_b005","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5216658115386963}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"nsp13":["N102S"]},"labels":{"aa":"nsp13: N102S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7831978797912598}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":92,"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"CL.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001027","node_attrs":{"div":94,"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.229829788208008}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"internal_2d50","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8071255683898926}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8071255683898926}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":89,"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.107795715332031}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"DJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.107795715332031}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001030","node_attrs":{"div":90,"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.246993541717529}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"DJ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"nsp14":["T173A"],"nsp5":["T24I"]},"labels":{"aa":"nsp14: T173A; nsp5: T24I"}}},{"name":"DJ.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF9b":["D2N"],"S":["L176F"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp4":["L106F"],"nsp8":["I185V"]},"labels":{"aa":"N: G5E; ORF9b: D2N; S: L176F; nsp1: G82-, H83-, V84-, M85-, V86-; nsp4: L106F; nsp8: I185V","spike_mutations":"L176F"}}},{"name":"NODE_0001031","node_attrs":{"div":92,"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"DJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"DJ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"NODE_0001032","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7332913875579834}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0832855701446533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0474534034729}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"nsp12":["G671C"]},"labels":{"aa":"nsp12: G671C"}}},{"name":"BA.5.1.32","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF9b":["V76F"],"nsp13":["P504S"],"nsp14":["D41N"]},"labels":{"aa":"N: S79I, A273S; ORF9b: V76F; nsp13: P504S; nsp14: D41N"}}},{"name":"BA.5.1.9","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.180713653564453}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF6":["D6G"],"nsp12":["M463V"]},"labels":{"aa":"ORF6: D6G; nsp12: M463V"}}},{"name":"NODE_0001033","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.130020618438721}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.533609390258789}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"nsp3":["K589M"]},"labels":{"aa":"nsp3: K589M"}}},{"name":"BA.5.1.36","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF9b":["L14F"],"S":["G261V"],"nsp7":["V33A"]},"labels":{"aa":"N: G18C; ORF9b: L14F; S: G261V; nsp7: V33A","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"NODE_0001034","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.150343418121338}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7931668758392334}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"S":["A262S"],"nsp2":["R27C"],"nsp7":["Q63R"]},"labels":{"aa":"E: S50G; S: A262S; nsp2: R27C; nsp7: Q63R","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001036","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"S":["R346T"],"nsp16":["T35I"]},"labels":{"aa":"S: R346T; nsp16: T35I","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001037","node_attrs":{"div":94,"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp3":["Q380R"]},"labels":{"aa":"S: Y144-; nsp3: Q380R","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"DF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7062840461730957}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7062840461730957}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001039","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6787030696868896}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6787030696868896}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5279"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.953214645385742}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.078192710876465}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"S":["N450D"],"nsp13":["H164Y"]},"labels":{"aa":"S: N450D; nsp13: H164Y","spike_mutations":"N450D"}}},{"name":"BF.19","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.091021537780762}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.17","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.485513687133789}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"nsp4":["D117N"]},"labels":{"aa":"nsp4: D117N"}}},{"name":"BF.33","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6034899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"S":["R346I","N460K"],"nsp12":["N791S"],"nsp16":["T35I"]},"labels":{"aa":"S: R346I, N460K; nsp12: N791S; nsp16: T35I","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.552757501602173}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.914626359939575}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4885289669036865}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0001040","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.624391078948975}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}},"children":[{"name":"BF.30","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C14599T","G22599C","C25916T"],"ORF3a":["T175I"],"S":["R346T"],"nsp3":["T204I"]},"labels":{"aa":"ORF3a: T175I; S: R346T; nsp3: T204I","spike_mutations":"R346T"}}},{"name":"BF.35","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF7a":["T14I"],"S":["N450D"],"nsp12":["M566I"],"nsp2":["L550R"]},"labels":{"aa":"ORF7a: T14I; S: N450D; nsp12: M566I; nsp2: L550R","spike_mutations":"N450D"}}}]},{"name":"NODE_0001041","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.26798677444458}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.26798677444458}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.001974582672119}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.001974582672119}},"branch_attrs":{"mutations":{}}},{"name":"BF.39.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.33263"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5959379308450252"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.379688739776611}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"S":["V445A","N450D"],"nsp13":["R155L"]},"labels":{"aa":"S: V445A, N450D; nsp13: R155L","spike_mutations":"V445A, N450D"}}}]},{"name":"internal_a7a7","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.132727146148682}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.132727146148682}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.41.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"S":["R346T"],"nsp1":["A138V"],"nsp5":["V297I"]},"labels":{"aa":"S: R346T; nsp1: A138V; nsp5: V297I","spike_mutations":"R346T"}}}]},{"name":"NODE_0001044","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.576507329940796}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.576507329940796}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.11.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF8":["I121N"],"nsp2":["S351G"]},"labels":{"aa":"ORF8: I121N; nsp2: S351G"}}},{"name":"BF.11.4","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.462855339050293}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"NODE_0001045","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.166012287139893}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.11.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"S":["K147N"],"nsp3":["T1250P"]},"labels":{"aa":"S: K147N; nsp3: T1250P","spike_mutations":"K147N"}}},{"name":"BF.11.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.11.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.292903900146484}},"branch_attrs":{"mutations":{"nuc":["C629T"],"nsp1":["L122F"]},"labels":{"aa":"nsp1: L122F"}}}]}]},{"name":"NODE_0001046","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7686774730682373}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7894070148468018}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"nsp12":["V320L"]},"labels":{"aa":"nsp12: V320L"}}},{"name":"BF.28","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2664027214050293}},"branch_attrs":{"mutations":{"nuc":["A396T"],"nsp1":["Q44L"]},"labels":{"aa":"nsp1: Q44L"}}},{"name":"BF.36","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"nsp1":["S166G"],"nsp13":["S350L","A505V"]},"labels":{"aa":"nsp1: S166G; nsp13: S350L, A505V"}}},{"name":"BF.9","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.462024211883545}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"nsp13":["A208V"],"nsp3":["G946S"],"nsp6":["Q27H"]},"labels":{"aa":"nsp13: A208V; nsp3: G946S; nsp6: Q27H"}}},{"name":"NODE_0001047","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1384172439575195}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"nsp13":["A368V"]},"labels":{"aa":"N: L13F; nsp13: A368V"}},"children":[{"name":"BF.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1384172439575195}},"branch_attrs":{"mutations":{}}},{"name":"BF.10.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3218"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.563032084337257"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}}]},{"name":"NODE_0001048","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.431779384613037}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"nsp16":["V288F"]},"labels":{"aa":"nsp16: V288F"}},"children":[{"name":"BF.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.431779384613037}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"nsp1":["E87D"],"nsp3":["Y107H","D165G"],"nsp5":["V261I"],"nsp6":["V289L"]},"labels":{"aa":"nsp1: E87D; nsp3: Y107H, D165G; nsp5: V261I; nsp6: V289L"}}}]},{"name":"NODE_0001049","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1216320991516113}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.382207870483398}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.540201187133789}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"nsp3":["T1456N"]},"labels":{"aa":"nsp3: T1456N"}}}]},{"name":"NODE_0001050","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.864048957824707}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF3a":["T175I"],"nsp2":["T44I","L462F"],"nsp3":["D117G"]},"labels":{"aa":"ORF3a: T175I; nsp2: T44I, L462F; nsp3: D117G"}}},{"name":"BF.27","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3812055587768555}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"nsp4":["A21V"]},"labels":{"aa":"nsp4: A21V"}}}]},{"name":"NODE_0001051","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.45866060256958}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.780573606491089}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"S":["R346S"],"nsp14":["K433R"],"nsp3":["K1771R"]},"labels":{"aa":"S: R346S; nsp14: K433R; nsp3: K1771R","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.740543842315674}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"NODE_0001052","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.68562650680542}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.741713047027588}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"nsp3":["L689F"]},"labels":{"aa":"nsp3: L689F"}}},{"name":"internal_faef","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48889999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2785964012146}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"internal_3b8c","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.661747455596924}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"nsp2":["G458C"]},"labels":{"aa":"nsp2: G458C"}}},{"name":"NODE_0001055","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160424709320068}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160424709320068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001056","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.755507469177246}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0001057","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"nsp4":["I110V"]},"labels":{"aa":"nsp4: I110V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.266281604766846}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001058","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.605588436126709}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"nsp6":["K270R"]},"labels":{"aa":"nsp6: K270R"}}},{"name":"NODE_0001059","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BF.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":114,"Nextclade_pango":{"value":"BF.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF3a":["P104S"],"nsp13":["V42I"],"nsp16":["H174Y"],"nsp2":["I387T"],"nsp3":["G334S","K1715R"],"nsp9":["T77I"]},"labels":{"aa":"ORF3a: P104S; nsp13: V42I; nsp16: H174Y; nsp2: I387T; nsp3: G334S, K1715R; nsp9: T77I"}}}]}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.604036331176758}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.42"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF7b":["F13-"],"ORF8":["I39V"],"nsp13":["P504L"],"nsp16":["K160R"],"nsp2":["T85I","T388I"],"nsp3":["A1769V"]},"labels":{"aa":"ORF7b: F13-; ORF8: I39V; nsp13: P504L; nsp16: K160R; nsp2: T85I, T388I; nsp3: A1769V"}}},{"name":"internal_928a","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.397202253341675}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"nsp12":["G385S"]},"labels":{"aa":"nsp12: G385S"}}},{"name":"BF.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257172107696533}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"S":["N450D"],"nsp12":["G671S"],"nsp3":["T734N"]},"labels":{"aa":"S: N450D; nsp12: G671S; nsp3: T734N","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416947364807129}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"S":["G446D"],"nsp3":["S126L"]},"labels":{"aa":"S: G446D; nsp3: S126L","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.40"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.287536382675171}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.238622665405273}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.238622665405273}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.38.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"S":["V445A"],"nsp12":["H613Y"]},"labels":{"aa":"S: V445A; nsp12: H613Y","spike_mutations":"V445A"}}},{"name":"BF.38.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.38.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}},{"name":"BF.38.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}}]},{"name":"NODE_0001063","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.12","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.18","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.17","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"S":["A688V","G1167S"],"nsp13":["I151V"],"nsp3":["A667V"]},"labels":{"aa":"S: A688V, G1167S; nsp13: I151V; nsp3: A667V","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.15","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"S":["G257D"],"nsp3":["A994V"]},"labels":{"aa":"S: G257D; nsp3: A994V","spike_mutations":"G257D"}}},{"name":"BF.7.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6393200000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9261090755462646}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.21","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.23","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.092196941375732}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"nsp12":["T248I"]},"labels":{"aa":"nsp12: T248I"}}},{"name":"BF.7.26","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.24","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.8","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0001064","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"nsp2":["A318V"]},"labels":{"aa":"nsp2: A318V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"S":["A688V"],"nsp3":["A1305V"]},"labels":{"aa":"S: A688V; nsp3: A1305V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001065","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0001066","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"nsp13":["P504L"]},"labels":{"aa":"nsp13: P504L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"S":["Y144-","G181V"],"nsp2":["H532N"]},"labels":{"aa":"M: H155Y; S: Y144-, G181V; nsp2: H532N","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001067","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"nsp2":["H208Y"],"nsp3":["H342Y"]},"labels":{"aa":"nsp2: H208Y; nsp3: H342Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6759999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001068","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"],"nsp2":["I293T"]},"labels":{"aa":"N: A90S; ORF7a: H47N; ORF9b: E86D; S: F157L; nsp2: I293T","spike_mutations":"F157L"}}},{"name":"BF.7.4","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001069","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3122618198394775}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"nsp13":["P504S"]},"labels":{"aa":"nsp13: P504S"}}},{"name":"BF.7.4.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"nsp14":["S221T"],"nsp3":["S1206L"]},"labels":{"aa":"nsp14: S221T; nsp3: S1206L"}}}]}]},{"name":"NODE_0001070","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF7a":["H47Y"],"nsp12":["L247F"]},"labels":{"aa":"ORF7a: H47Y; nsp12: L247F"}},"children":[{"name":"BF.7.27","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0001071","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"S":["C1243F"],"nsp2":["V94L"]},"labels":{"aa":"S: C1243F; nsp2: V94L","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"nsp3":["I385V"],"nsp4":["K138T"]},"labels":{"aa":"nsp3: I385V; nsp4: K138T"}}},{"name":"BF.7.14.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"nsp3":["T1026I"]},"labels":{"aa":"nsp3: T1026I"}}},{"name":"BF.7.14.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.325514793395996}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0001072","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0001073","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6321189403533936}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.815160036087036}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.182589054107666}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.40"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"S":["L5F","N450D"],"nsp15":["D16Y"],"nsp2":["G115C"]},"labels":{"aa":"S: L5F, N450D; nsp15: D16Y; nsp2: G115C","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"nsp3":["C296F","P395L"],"nsp6":["A161V"]},"labels":{"aa":"nsp3: C296F, P395L; nsp6: A161V"}}},{"name":"BA.5.2.9","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.992318630218506}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"nsp12":["Y521C"]},"labels":{"aa":"nsp12: Y521C"}}},{"name":"NODE_0001074","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2580161094665527}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"nsp13":["T127N"]},"labels":{"aa":"nsp13: T127N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.743117332458496}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"nsp3":["M265I"]},"labels":{"aa":"N: A125T; nsp3: M265I"}}},{"name":"BA.5.2.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.626256227493286}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"nsp15":["G246S"]},"labels":{"aa":"N: R413S; nsp15: G246S"}}},{"name":"NODE_0001075","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.856178045272827}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.856178045272827}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"S":["K444M"],"nsp3":["S702F"]},"labels":{"aa":"S: K444M; nsp3: S702F","spike_mutations":"K444M"}}}]},{"name":"NODE_0001076","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.190217971801758}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.498509168624878}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"nsp3":["T204I"]},"labels":{"aa":"nsp3: T204I"}}},{"name":"BA.5.2.28","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2399187088012695}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"nsp3":["T619I"]},"labels":{"aa":"nsp3: T619I"}}},{"name":"BA.5.2.29","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.531074523925781}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"nsp12":["T26I"]},"labels":{"aa":"nsp12: T26I"}}},{"name":"BA.5.2.45","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5131699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.45"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.998836994171143}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.52"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161757469177246}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"S":["N450D"],"nsp3":["D1242N"]},"labels":{"aa":"S: N450D; nsp3: D1242N","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.55"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.999176263809204}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.59"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.273857593536377}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0001077","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9824564456939697}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9824564456939697}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39901000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.402862548828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0001078","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.6803436279296875}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"S":["T883I"],"nsp13":["S74P"]},"labels":{"aa":"S: T883I; nsp13: S74P","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.6803436279296875}},"branch_attrs":{"mutations":{}}},{"name":"DZ.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"DZ.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"S":["D1146Y"],"nsp6":["L98F"]},"labels":{"aa":"S: D1146Y; nsp6: L98F","spike_mutations":"D1146Y"}}}]}]},{"name":"NODE_0001079","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.190217971801758}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"S":["W64L","K444M"],"nsp3":["T1334I"]},"labels":{"aa":"S: W64L, K444M; nsp3: T1334I","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.12","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3988966941833496}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6936419010162354}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"S":["R346T"],"nsp10":["I38V"]},"labels":{"aa":"S: R346T; nsp10: I38V","spike_mutations":"R346T"}}},{"name":"BA.5.2.19","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7941067218780518}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.567555904388428}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.34","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5116841793060303}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"S":["R346T"],"nsp14":["V14L"]},"labels":{"aa":"S: R346T; nsp14: V14L","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6543288230895996}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460197925567627}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.42"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"S":["K444T","L981I"],"nsp13":["S259L"],"nsp3":["A1431V"],"nsp6":["L260F"]},"labels":{"aa":"S: K444T, L981I; nsp13: S259L; nsp3: A1431V; nsp6: L260F","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5642800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5413273873731987"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.43"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"S":["G446D","N460K"],"nsp3":["A861V"]},"labels":{"aa":"S: G446D, N460K; nsp3: A861V","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.44"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.282502174377441}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"nsp3":["L1746F"]},"labels":{"aa":"nsp3: L1746F"}}},{"name":"BA.5.2.46","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.46"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"S":["K444T","N460K"],"nsp2":["K330E"]},"labels":{"aa":"S: K444T, N460K; nsp2: K330E","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.53"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.239440441131592}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.54"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.244083881378174}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.57","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.57"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7188966274261475}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.58","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.58"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.236837387084961}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.62"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.200337886810303}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.63"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"],"nsp2":["A596V"],"nsp3":["T976I"]},"labels":{"aa":"ORF6: Y31C; S: Y144-, K444N, N460K; nsp2: A596V; nsp3: T976I","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.61","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.61"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.71628475189209}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"S":["N450D"],"nsp15":["Q19L"]},"labels":{"aa":"S: N450D; nsp15: Q19L","spike_mutations":"N450D"}}},{"name":"BA.5.2.8","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.947103977203369}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"nsp4":["L106F"]},"labels":{"aa":"nsp4: L106F"}}},{"name":"internal_236a","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3597493171691895}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.216500759124756}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.365072250366211}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.812326431274414}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"nsp3":["I1514V"]},"labels":{"aa":"nsp3: I1514V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.812326431274414}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.800739765167236}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_1651","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.183862686157227}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.183862686157227}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4564899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7208595659836455"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.672360420227051}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.363097667694092}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.56458"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.30660604695253"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.363097667694092}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"DA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6759999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.474554061889648}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001084","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.726138114929199}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"S":["K444R"],"nsp4":["S34F"]},"labels":{"aa":"S: K444R; nsp4: S34F","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.56"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.041224479675293}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.329527378082275}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.329527378082275}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0001086","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.852180480957031}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.280701637268066}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"NODE_0001087","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4698431491851807}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4698431491851807}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"CN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"nsp1":["K120N"]},"labels":{"aa":"nsp1: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{}}},{"name":"BZ.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"S":["Q677H"],"nsp1":["S17N"],"nsp13":["E365D"]},"labels":{"aa":"S: Q677H; nsp1: S17N; nsp13: E365D","spike_mutations":"Q677H"}}},{"name":"BZ.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"S":["N450D"],"nsp4":["H31Y"]},"labels":{"aa":"S: N450D; nsp4: H31Y","spike_mutations":"N450D"}}}]},{"name":"internal_74ef","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.185973167419434}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.185973167419434}},"branch_attrs":{"mutations":{}}},{"name":"CD.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5594199999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3253063676642168"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"S":["A435S"],"nsp3":["A1280V"]},"labels":{"aa":"N: D144N; S: A435S; nsp3: A1280V","spike_mutations":"A435S"}}},{"name":"CD.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"CD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.5595383644104}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}}]},{"name":"NODE_0001090","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.06477689743042}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"nsp14":["P203L"]},"labels":{"aa":"nsp14: P203L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.50"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.740553379058838}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"nsp3":["S1670F"]},"labels":{"aa":"nsp3: S1670F"}}},{"name":"BA.5.2.51","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.51"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.60"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585160732269287}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"S":["N450D"],"nsp6":["K263R"]},"labels":{"aa":"S: N450D; nsp6: K263R","spike_mutations":"N450D"}}}]},{"name":"NODE_0001091","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.064579010009766}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"S":["K444M"],"nsp2":["M418T"]},"labels":{"aa":"S: K444M; nsp2: M418T","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.064579010009766}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"S":["T1066N"],"nsp3":["I1672S"]},"labels":{"aa":"N: P20S; S: T1066N; nsp3: I1672S","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0001092","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"nsp6":["A128V"]},"labels":{"aa":"nsp6: A128V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.205173492431641}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"S":["Y144-","K444M","N460K"],"nsp5":["A94V"]},"labels":{"aa":"S: Y144-, K444M, N460K; nsp5: A94V","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"BU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"S":["K147N","N450D"],"nsp3":["I414T"]},"labels":{"aa":"S: K147N, N450D; nsp3: I414T","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.415645122528076}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.415645122528076}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.35650110244751}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"DB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"S":["Y144-","R346T","N460K"],"nsp14":["M501I"],"nsp2":["A510V"]},"labels":{"aa":"S: Y144-, R346T, N460K; nsp14: M501I; nsp2: A510V","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"DB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.673305034637451}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"internal_93c4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.993546485900879}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0001096","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.665866374969482}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.665866374969482}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001097","node_attrs":{"div":92,"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3630194664001465}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"S":["V62I"],"nsp3":["T183I"]},"labels":{"aa":"S: V62I; nsp3: T183I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40216999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"S":["V445A"],"nsp2":["S263F"]},"labels":{"aa":"N: D377Y; S: V445A; nsp2: S263F","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"S":["H146Q"],"nsp3":["D1774G"]},"labels":{"aa":"S: H146Q; nsp3: D1774G","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0001098","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7056260108947754}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"NODE_0001099","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"S":["K147E"],"nsp14":["T113I"],"nsp2":["M135V"]},"labels":{"aa":"S: K147E; nsp14: T113I; nsp2: M135V","spike_mutations":"K147E"}}}]},{"name":"NODE_0001100","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8918910026550293}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5254948139190674}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"DY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7626357078552246}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"nsp3":["T970M"]},"labels":{"aa":"nsp3: T970M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2117156982421875}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2117156982421875}},"branch_attrs":{"mutations":{}}},{"name":"CP.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6942999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5295255377787571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.206465721130371}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"S":["Y144-","N334K"],"nsp12":["A529T"]},"labels":{"aa":"S: Y144-, N334K; nsp12: A529T","spike_mutations":"Y144-, N334K"}}},{"name":"CP.4","node_attrs":{"div":93,"Nextclade_pango":{"value":"CP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.632293224334717}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.982746124267578}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"CP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.38661"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.8310227394104}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"S":["N460Y"],"nsp5":["K90R"]},"labels":{"aa":"S: N460Y; nsp5: K90R","spike_mutations":"N460Y"}}},{"name":"CP.6","node_attrs":{"div":92,"Nextclade_pango":{"value":"CP.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.885945796966553}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"CP.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"],"nsp2":["Y2H"]},"labels":{"aa":"E: I9T; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y; nsp2: Y2H","spike_mutations":"N703Y"}}},{"name":"internal_7ebe","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"nsp14":["D415G"]},"labels":{"aa":"nsp14: D415G"}},"children":[{"name":"CP.8","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CP.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"S":["P812R"],"nsp14":["L177I"],"nsp3":["P141S","A1179V","V1315I"]},"labels":{"aa":"S: P812R; nsp14: L177I; nsp3: P141S, A1179V, V1315I","spike_mutations":"P812R"}}}]},{"name":"NODE_0001103","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.436225414276123}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.436225414276123}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.319653511047363}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"S":["K150N"],"nsp3":["S1296F"]},"labels":{"aa":"S: K150N; nsp3: S1296F","spike_mutations":"K150N"}}},{"name":"CP.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.3846282958984375}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6003199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"S":["Y144-","G446S"],"nsp6":["A128V"]},"labels":{"aa":"S: Y144-, G446S; nsp6: A128V","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"NODE_0001104","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.071214199066162}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.071214199066162}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.241343975067139}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.667091369628906}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.667091369628906}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.376060962677002}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.376060962677002}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001107","node_attrs":{"div":97,"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"S":["S255F"],"nsp2":["V530I"],"nsp6":["G9D"]},"labels":{"aa":"S: S255F; nsp2: V530I; nsp6: G9D","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CK.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0001108","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.083750247955322}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.083750247955322}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0001109","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.607499599456787}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"CK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"nsp6":["M164V"]},"labels":{"aa":"nsp6: M164V"}}},{"name":"CK.1.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}}]},{"name":"NODE_0001110","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.002077102661133}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"CK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.712399482727051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"CK.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.71883"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"S":["-144Y","R346T"],"nsp4":["S34F"]},"labels":{"aa":"S: -144Y, R346T; nsp4: S34F","spike_mutations":"-144Y, R346T"}}}]},{"name":"NODE_0001111","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.022307395935059}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"S":["E654K"],"nsp3":["T970M"]},"labels":{"aa":"S: E654K; nsp3: T970M","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.657642364501953}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CK.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.022307395935059}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]}]},{"name":"NODE_0001112","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161224365234375}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"nsp2":["Q376K"]},"labels":{"aa":"nsp2: Q376K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161224365234375}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:72-122"},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7826626300811768}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp3":["S1375F"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; nsp1: G82-, H83-, V84-, M85-, V86-; nsp3: S1375F"}}},{"name":"BA.5.3.5","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3075408935546875}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"R346T"}}},{"name":"NODE_0001113","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8096206188201904}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9212589263916016}},"branch_attrs":{"mutations":{"nuc":["G621A"],"nsp1":["R119H"]},"labels":{"aa":"nsp1: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.250945091247559}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"nsp16":["M20I"]},"labels":{"aa":"nsp16: M20I"}}}]},{"name":"NODE_0001114","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{}}},{"name":"BE.3","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2200913429260254}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"nsp13":["Y324C"]},"labels":{"aa":"N: P151S; nsp13: Y324C"}}},{"name":"BE.5","node_attrs":{"div":84,"Nextclade_pango":{"value":"BE.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{}}},{"name":"BE.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"BE.8"},"qc.stopCodons.totalStopCodons":{"value":1},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":94},"qc.overallScore":{"value":56.25},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C1853T","C14178T","C22498T","G22599C","C26110T","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-","A27748-","T28693C"],"ORF3a":["P240S"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-","K119*"],"S":["R346T"],"nsp1":["M85-"]},"labels":{"aa":"ORF3a: P240S; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-, K119*; S: R346T; nsp1: M85-","spike_mutations":"R346T"}}},{"name":"NODE_0001115","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4670610427856445}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BE.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"nsp1":["S74L"],"nsp4":["S59F"],"nsp7":["M52T"]},"labels":{"aa":"nsp1: S74L; nsp4: S59F; nsp7: M52T"}}},{"name":"BE.9","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.663193702697754}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"S":["Y144-"],"nsp1":["V84-","M85-"]},"labels":{"aa":"S: Y144-; nsp1: V84-, M85-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0001116","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6816246509552}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.12","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.008347988128662}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0001117","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.286231994628906}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T"],"nsp1":["M85-"]},"labels":{"aa":"nsp1: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.737891674041748}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0001118","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.440604209899902}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":94,"Nextclade_pango":{"value":"BE.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5231200000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5088823627149919"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","-519T","-520G","T2665C","C3176T","T22624C","A22995G","C23802T","A26170G","C27393T"],"ORF3a":["M260V"],"S":["K478R","T747I"],"nsp3":["P153S"]},"labels":{"aa":"ORF3a: M260V; S: K478R, T747I; nsp3: P153S","spike_mutations":"K478R, T747I"}}},{"name":"BE.7","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.440604209899902}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0001119","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.679184913635254}},"branch_attrs":{"mutations":{"nuc":["C13342T"]}},"children":[{"name":"BE.2","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8559343814849854}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G"],"nsp3":["T64I"]},"labels":{"aa":"nsp3: T64I"}}},{"name":"NODE_0001120","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{"nuc":["C10188A","C27800T"],"nsp5":["T45N"]},"labels":{"aa":"nsp5: T45N"}},"children":[{"name":"BE.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001121","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281903266906738}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.614480018615723}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0001122","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"S":["P209L","R346T"],"nsp3":["T350I"]},"labels":{"aa":"S: P209L, R346T; nsp3: T350I","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001123","node_attrs":{"div":92,"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BE.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"CQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40216999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9200549125671387}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"],"nsp3":["H323Y"]},"labels":{"aa":"S: Y144-, V445A; nsp3: H323Y","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0001124","node_attrs":{"div":93,"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"CQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"CQ.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"CQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]}]}]}]}]}]},{"name":"NODE_0001125","node_attrs":{"div":85,"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.024914026260376}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"nsp13":["M233I"]},"labels":{"aa":"nsp13: M233I"}},"children":[{"name":"BE.1","node_attrs":{"div":85,"Nextclade_pango":{"value":"BE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.024914026260376}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"S":["M153I","E1258Q"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp2":["L274F"]},"labels":{"aa":"N: P151L; S: M153I, E1258Q; nsp1: G82-, H83-, V84-, M85V; nsp2: L274F","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0001126","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.295690059661865}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.295690059661865}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001127","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"S":["V445A"],"nsp2":["F498L"]},"labels":{"aa":"S: V445A; nsp2: F498L","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49383999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8224959014481948"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"S":["N460S"],"nsp4":["T73I"]},"labels":{"aa":"S: N460S; nsp4: T73I","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0001128","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"nsp14":["V263I"]},"labels":{"aa":"nsp14: V263I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BE.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0001129","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.36769437789917}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BE.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BE.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"],"nsp16":["K160R"],"nsp5":["I78T"]},"labels":{"aa":"ORF8: P93T; ORF9b: S10F; S: R346T; nsp16: K160R; nsp5: I78T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0001130","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7709906101226807}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"nsp6":["L260F"]},"labels":{"aa":"nsp6: L260F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7709906101226807}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001131","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"S":["N450D"],"nsp3":["K384N"]},"labels":{"aa":"S: N450D; nsp3: K384N","spike_mutations":"N450D"}}}]},{"name":"BE.1.1_internal","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.037106990814209}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.037106990814209}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45205000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5680790723509552"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.677981853485107}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0001133","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3801355361938477}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"S":["N460K"],"nsp12":["Y273H"]},"labels":{"aa":"S: N460K; nsp12: Y273H","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3801355361938477}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.14","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4368529319763184}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.12","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3855841159820557}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.19","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6127800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7257362514460642"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.9549241065979}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.17","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.20","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5446"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8308113969466171"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.457104682922363}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6570799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"S":["Y144-","R346S"],"nsp3":["T1269I"]},"labels":{"aa":"S: Y144-, R346S; nsp3: T1269I","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.424004077911377}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.32","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.946379661560059}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.31","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.428726673126221}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.459336757659912}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"nsp13":["T153I"]},"labels":{"aa":"nsp13: T153I"}}},{"name":"BQ.1.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"S":["R190T"],"nsp3":["V1847I"]},"labels":{"aa":"N: H300Q; S: R190T; nsp3: V1847I","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.914120197296143}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9833500385284424}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"nsp1":["G94C"]},"labels":{"aa":"nsp1: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.657703399658203}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"S":["R346T"],"nsp3":["V1786I"]},"labels":{"aa":"S: R346T; nsp3: V1786I","spike_mutations":"R346T"}}},{"name":"NODE_0001134","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"S":["L5F","Y144-"],"nsp1":["H110Y"],"nsp3":["E815D"]},"labels":{"aa":"S: L5F, Y144-; nsp1: H110Y; nsp3: E815D","spike_mutations":"L5F, Y144-"}}},{"name":"BQ.1.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001135","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"nsp2":["V447I"]},"labels":{"aa":"nsp2: V447I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0001136","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF3a":["R68I"],"nsp15":["P270L"],"nsp3":["V1339I"]},"labels":{"aa":"ORF3a: R68I; nsp15: P270L; nsp3: V1339I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0001137","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"nsp4":["L353F"]},"labels":{"aa":"nsp4: L353F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001138","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.009603977203369}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"nsp3":["V34A"]},"labels":{"aa":"nsp3: V34A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.111164569854736}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"NODE_0001139","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.710926055908203}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.710926055908203}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001140","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF7b":["A15S"],"nsp2":["S68N"]},"labels":{"aa":"ORF7b: A15S; nsp2: S68N"}}},{"name":"BQ.1.26.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.26.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"internal_56b3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.176206588745117}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.176206588745117}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8304200172424316}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0001143","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"S":["E619Q"],"nsp5":["L30I"]},"labels":{"aa":"S: E619Q; nsp5: L30I","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"nsp3":["L1035F"]},"labels":{"aa":"nsp3: L1035F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0001145","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"nsp2":["E172A"]},"labels":{"aa":"nsp2: E172A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6353800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6853534127590314"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":97,"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"EC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4688456058502197}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4688456058502197}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875691413879395}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"NODE_0001149","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66664"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9874397743924017"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"],"nsp1":["M85-"],"nsp14":["E364K"]},"labels":{"aa":"ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K; nsp1: M85-; nsp14: E364K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0001150","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"S":["F186-","K187-","N188Y"],"nsp1":["G82-","H83-","V84-"]},"labels":{"aa":"S: F186-, K187-, N188Y; nsp1: G82-, H83-, V84-","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6059300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":31},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:83-122"},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0821590912755812"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"],"nsp12":["V473F"],"nsp13":["T530A"],"nsp2":["L400F","L550F"]},"labels":{"aa":"ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A; nsp12: V473F; nsp13: T530A; nsp2: L400F, L550F","spike_mutations":"A484K, V486A"}}}]}]},{"name":"internal_dbfb","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"S":["Y144-"],"nsp13":["P504S"]},"labels":{"aa":"N: H300N; S: Y144-; nsp13: P504S","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5174000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6925976779449897"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"S":["K478R"],"nsp3":["G175D"]},"labels":{"aa":"S: K478R; nsp3: G175D","spike_mutations":"K478R"}}},{"name":"FB.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}}]}]},{"name":"internal_efa8","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.758645534515381}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"nsp13":["N268S"]},"labels":{"aa":"nsp13: N268S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.5464024543762207}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"nsp2":["A360V"]},"labels":{"aa":"nsp2: A360V"}}},{"name":"BQ.1.23","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4521589279174805}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.057005882263184}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.637411117553711}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp2":["S325F"]},"labels":{"aa":"S: Y144-; nsp2: S325F","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"S":["S256L","Q613H","V1164I"],"nsp13":["T588I"],"nsp2":["I216V"]},"labels":{"aa":"S: S256L, Q613H, V1164I; nsp13: T588I; nsp2: I216V","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0001155","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.39292049407959}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.39292049407959}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8915650844573975}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.535731792449951}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"S":["S494P"],"nsp10":["T115I"]},"labels":{"aa":"S: S494P; nsp10: T115I","spike_mutations":"S494P"}}},{"name":"BQ.1.1.17","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.149693012237549}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"nsp3":["S1455F"]},"labels":{"aa":"nsp3: S1455F"}}},{"name":"BQ.1.1.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.5311388969421387}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.19","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.22513484954834}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7449699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.073467254638672}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5921799999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8728938682420008"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.841221332550049}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.31","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8330674171447754}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.30","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.34","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.100788593292236}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.36","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.201074600219727}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.314393997192383}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.40","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"S":["Y144-","S704L"],"nsp2":["D23N"]},"labels":{"aa":"S: Y144-, S704L; nsp2: D23N","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.41","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9046711921691895}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"S":["K182I"],"nsp3":["A1711V"]},"labels":{"aa":"S: K182I; nsp3: A1711V","spike_mutations":"K182I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.068450927734375}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.47","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.249934673309326}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"S":["K147I"],"nsp4":["V434M"]},"labels":{"aa":"S: K147I; nsp4: V434M","spike_mutations":"K147I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7044405937194824}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.50","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.386298179626465}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"S":["Y144-","I210-"],"nsp12":["T801I"],"nsp2":["K489R"]},"labels":{"aa":"S: Y144-, I210-; nsp12: T801I; nsp2: K489R","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9954097270965576}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.56","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.530673980712891}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.57","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.360785007476807}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.55","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.861405849456787}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.58","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.378433704376221}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.60","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9752705097198486}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"nsp2":["L501F"]},"labels":{"aa":"nsp2: L501F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.371273994445801}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"S":["Y248H"],"nsp14":["V328I"]},"labels":{"aa":"S: Y248H; nsp14: V328I","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.64","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.916878700256348}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.276081562042236}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.67","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.056059837341309}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"S":["L176F"],"nsp3":["T1063I","T1336I"]},"labels":{"aa":"S: L176F; nsp3: T1063I, T1336I","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"nsp3":["V393I"]},"labels":{"aa":"nsp3: V393I"}}},{"name":"BQ.1.1.69","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.636171579360962}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"nsp14":["S503L"]},"labels":{"aa":"nsp14: S503L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8411405086517334}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"nsp3":["A85V"]},"labels":{"aa":"M: S212G; nsp3: A85V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.75","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04867000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.051732686328446"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2394514083862305}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp13":["A505V"]},"labels":{"aa":"S: Y144-; nsp13: A505V","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.7311859130859375}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.20283317565918}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.20283317565918}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.70602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.6625657081604}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"S":["G446S"],"nsp1":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"]},"labels":{"aa":"S: G446S; nsp1: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-","spike_mutations":"G446S"}}}]},{"name":"NODE_0001157","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.65602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.9605560302734375}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001158","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0001159","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.942479372024536}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.781022071838379}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.530292510986328}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"S":["G181R"],"nsp4":["F101L"]},"labels":{"aa":"S: G181R; nsp4: F101L","spike_mutations":"G181R"}}}]},{"name":"NODE_0001160","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.500977516174316}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"nsp3":["A1711T"]},"labels":{"aa":"nsp3: A1711T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"S":["K147E"],"nsp3":["A994T"]},"labels":{"aa":"S: K147E; nsp3: A994T","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"ET.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0001162","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"ES.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001163","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{"nuc":["C912A"],"nsp2":["S36Y"]},"labels":{"aa":"nsp2: S36Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74371"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.994874477386475}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"S":["D339N"],"nsp3":["A991T"]},"labels":{"aa":"S: D339N; nsp3: A991T","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.452545642852783}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"nsp12":["D109A"]},"labels":{"aa":"nsp12: D109A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.452545642852783}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.918569087982178}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bf35","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.695055961608887}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.695055961608887}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001166","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.212834358215332}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"nsp2":["H194Y"],"nsp3":["L151F"]},"labels":{"aa":"nsp2: H194Y; nsp3: L151F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.212834358215332}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66913"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9105813557217661"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"NODE_0001167","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9088196754455566}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9088196754455566}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.81001615524292}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"internal_edc4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8035850524902344}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"nsp14":["V115A"]},"labels":{"aa":"nsp14: V115A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8035850524902344}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6774299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001169","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001170","node_attrs":{"div":95,"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"ER.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{}}},{"name":"ER.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"ER.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF8":["P38S"],"S":["G257S"],"nsp2":["P181S"]},"labels":{"aa":"ORF8: P38S; S: G257S; nsp2: P181S","spike_mutations":"G257S"}}}]}]},{"name":"NODE_0001171","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.548947811126709}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"DR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001172","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6486213207244873}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.388934135437012}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.766948699951172}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"S":["H1083D"],"nsp2":["I472V"]},"labels":{"aa":"S: H1083D; nsp2: I472V","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.1.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"nsp14":["P429L"],"nsp2":["M135I"]},"labels":{"aa":"nsp14: P429L; nsp2: M135I"}}}]},{"name":"NODE_0001173","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001174","node_attrs":{"div":96,"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"EN.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}}]}]},{"name":"internal_1117","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504777908325195}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504777908325195}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.83009147644043}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_f9e1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"EA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478137493133545}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.34834999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.880706782961692"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.922173023223877}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_159a","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{}}},{"name":"ED.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"ED.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.188085079193115}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"nsp3":["D110Y"]},"labels":{"aa":"nsp3: D110Y"}}},{"name":"ED.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"ED.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.897581100463867}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}},{"name":"ED.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"ED.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6314659118652344}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF3a":["L108F"],"nsp2":["C253S"]},"labels":{"aa":"ORF3a: L108F; nsp2: C253S"}}}]},{"name":"NODE_0001178","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.167686462402344}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0001179","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"S":["P251L"],"nsp13":["P53S"]},"labels":{"aa":"S: P251L; nsp13: P53S","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.00280237197876}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.00280237197876}},"branch_attrs":{"mutations":{}}},{"name":"DT.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"DT.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.66092586517334}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"DT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.224767684936523}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}},{"name":"DT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"S":["S494P"],"nsp3":["S1682F"]},"labels":{"aa":"S: S494P; nsp3: S1682F","spike_mutations":"S494P"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.117684841156006}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4302690029144287}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0001183","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4922916889190674}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4922916889190674}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.18422269821167}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.131554126739502}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"nsp14":["V14I"]},"labels":{"aa":"nsp14: V14I"}}},{"name":"EE.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.522237777709961}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.840278148651123}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0001185","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.25513219833374}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0001186","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"S":["A701V"],"nsp15":["N28S"]},"labels":{"aa":"S: A701V; nsp15: N28S","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.65602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001187","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0001188","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"S":["Q613H"],"nsp2":["V258I"]},"labels":{"aa":"S: Q613H; nsp2: V258I","spike_mutations":"Q613H"}}}]},{"name":"NODE_0001189","node_attrs":{"div":101,"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":101,"Nextclade_pango":{"value":"BQ.1.1.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24659999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"EV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24659999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0001190","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.141762733459473}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.141762733459473}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"nsp12":["V128I"]},"labels":{"aa":"nsp12: V128I"}}},{"name":"EF.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"EF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.072010517120361}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"NODE_0001191","node_attrs":{"div":96,"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{}}},{"name":"internal_bc60","node_attrs":{"div":97,"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.138625144958496}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"EF.1.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"internal_e491","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.127105712890625}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.127105712890625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001194","node_attrs":{"div":99,"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0001195","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"nsp15":["P262L"],"nsp6":["V286I"]},"labels":{"aa":"nsp15: P262L; nsp6: V286I"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6995503902435303}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"nsp15":["D300N"]},"labels":{"aa":"nsp15: D300N"}}},{"name":"NODE_0001196","node_attrs":{"div":97,"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.508324146270752}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"nsp3":["V207L"]},"labels":{"aa":"nsp3: V207L"}},"children":[{"name":"DN.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"DN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.508324146270752}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-7.333120346069336}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0001197","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001198","node_attrs":{"div":99,"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"nsp3":["R1341W"]},"labels":{"aa":"nsp3: R1341W"}},"children":[{"name":"DN.1.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.05606"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8990816968865659"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"S":["Y453F"],"nsp2":["V541I"],"nsp3":["N1934S"]},"labels":{"aa":"S: Y453F; nsp2: V541I; nsp3: N1934S","spike_mutations":"Y453F"}}},{"name":"DN.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"DN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5626099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8771384492554943"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6722600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8744814686582322"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA*","ORF10":"MGYINVFAFPFTIYSLLLCRMNSRNYIAQVDVVNFNLT*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nsp1":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG","nsp10":"AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQ","nsp11":"SADAQSFLNGFAV","nsp12":"SADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ","nsp13":"AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQ","nsp14":"AENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQ","nsp15":"SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ","nsp16":"SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN","nsp2":"AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGG","nsp3":"APTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGG","nsp4":"KIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQ","nsp5":"SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ","nsp6":"SAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQ","nsp7":"SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQ","nsp8":"AIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQ","nsp9":"NNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}} diff --git a/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json.bak b/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json.bak new file mode 100644 index 00000000..4024c152 --- /dev/null +++ b/data/nextstrain/sars-cov-2/wuhan-hu-1/proteins/tree.json.bak @@ -0,0 +1 @@ +{"version":"v2","meta":{"title":"SARS-CoV-2 phylogeny","updated":"2024-09-25","build_url":"https://github.com/neherlab/nextclade_data_workflows","maintainers":[{"name":"Cornelius Roemer","url":"https://neherlab.org"},{"name":"Richard Neher","url":"https://neherlab.org"}],"display_defaults":{"color_by":"clade_membership","distance_measure":"div","map_triplicate":false,"branch_label":"clade","transmission_lines":false},"genome_annotations":{"E":{"end":26472,"seqid":"profiles/clades/proteins/reference_seq.gb","start":26245,"strand":"+","type":"CDS"},"M":{"end":27191,"seqid":"profiles/clades/proteins/reference_seq.gb","start":26523,"strand":"+","type":"CDS"},"N":{"end":29533,"seqid":"profiles/clades/proteins/reference_seq.gb","start":28274,"strand":"+","type":"CDS"},"ORF10":{"end":29674,"seqid":"profiles/clades/proteins/reference_seq.gb","start":29558,"strand":"+","type":"CDS"},"ORF3a":{"end":26220,"seqid":"profiles/clades/proteins/reference_seq.gb","start":25393,"strand":"+","type":"CDS"},"ORF6":{"end":27387,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27202,"strand":"+","type":"CDS"},"ORF7a":{"end":27759,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27394,"strand":"+","type":"CDS"},"ORF7b":{"end":27887,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27756,"strand":"+","type":"CDS"},"ORF8":{"end":28259,"seqid":"profiles/clades/proteins/reference_seq.gb","start":27894,"strand":"+","type":"CDS"},"ORF9b":{"end":28577,"seqid":"profiles/clades/proteins/reference_seq.gb","start":28284,"strand":"+","type":"CDS"},"S":{"end":25384,"seqid":"profiles/clades/proteins/reference_seq.gb","start":21563,"strand":"+","type":"CDS"},"nsp1":{"end":805,"seqid":"profiles/clades/proteins/reference_seq.gb","start":266,"strand":"+","type":"CDS"},"nsp10":{"end":13441,"seqid":"profiles/clades/proteins/reference_seq.gb","start":13025,"strand":"+","type":"CDS"},"nsp11":{"end":13480,"seqid":"profiles/clades/proteins/reference_seq.gb","start":13442,"strand":"+","type":"CDS"},"nsp12":{"seqid":"profiles/clades/proteins/reference_seq.gb","strand":"+","type":"CDS","segments":[{"start":13442,"end":13468},{"start":13468,"end":16236}]},"nsp13":{"end":18039,"seqid":"profiles/clades/proteins/reference_seq.gb","start":16237,"strand":"+","type":"CDS"},"nsp14":{"end":19620,"seqid":"profiles/clades/proteins/reference_seq.gb","start":18040,"strand":"+","type":"CDS"},"nsp15":{"end":20658,"seqid":"profiles/clades/proteins/reference_seq.gb","start":19621,"strand":"+","type":"CDS"},"nsp16":{"end":21552,"seqid":"profiles/clades/proteins/reference_seq.gb","start":20659,"strand":"+","type":"CDS"},"nsp2":{"end":2719,"seqid":"profiles/clades/proteins/reference_seq.gb","start":806,"strand":"+","type":"CDS"},"nsp3":{"end":8554,"seqid":"profiles/clades/proteins/reference_seq.gb","start":2720,"strand":"+","type":"CDS"},"nsp4":{"end":10054,"seqid":"profiles/clades/proteins/reference_seq.gb","start":8555,"strand":"+","type":"CDS"},"nsp5":{"end":10972,"seqid":"profiles/clades/proteins/reference_seq.gb","start":10055,"strand":"+","type":"CDS"},"nsp6":{"end":11842,"seqid":"profiles/clades/proteins/reference_seq.gb","start":10973,"strand":"+","type":"CDS"},"nsp7":{"end":12091,"seqid":"profiles/clades/proteins/reference_seq.gb","start":11843,"strand":"+","type":"CDS"},"nsp8":{"end":12685,"seqid":"profiles/clades/proteins/reference_seq.gb","start":12092,"strand":"+","type":"CDS"},"nsp9":{"end":13024,"seqid":"profiles/clades/proteins/reference_seq.gb","start":12686,"strand":"+","type":"CDS"},"nuc":{"end":29903,"start":1,"strand":"+","type":"source"}},"description":"This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n","colorings":[{"key":"clade_membership","title":"Clade","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"gt","title":"Genotype","type":"categorical"},{"key":"designation_date","title":"Designation date","type":"categorical","scale":[["2021-02-18","#531EA6"],["2021-02-21","#521EA7"],["2021-03-02","#4E20AC"],["2021-03-10","#4C24AF"],["2021-03-15","#4B26B1"],["2021-04-01","#472DB8"],["2021-04-07","#462FBA"],["2021-04-08","#4530BB"],["2021-04-13","#4432BD"],["2021-04-19","#4334BF"],["2021-04-20","#4335C0"],["2021-04-21","#4235C0"],["2021-04-23","#4236C1"],["2021-04-26","#4137C2"],["2021-04-30","#4039C4"],["2021-05-05","#403BC5"],["2021-05-13","#4040C6"],["2021-05-16","#4041C7"],["2021-05-21","#3F44C8"],["2021-05-25","#3F46C8"],["2021-05-26","#3F46C9"],["2021-06-04","#3F4BCA"],["2021-06-14","#3F50CC"],["2021-06-18","#3F53CD"],["2021-06-19","#3F53CD"],["2021-06-25","#3F56CE"],["2021-06-30","#3E59CF"],["2021-07-01","#3E59CF"],["2021-07-13","#3F5FD0"],["2021-07-22","#4064CF"],["2021-07-23","#4064CF"],["2021-07-26","#4066CF"],["2021-07-27","#4066CF"],["2021-07-28","#4067CF"],["2021-07-30","#4068CF"],["2021-08-02","#4169CF"],["2021-08-03","#416ACF"],["2021-08-04","#416ACF"],["2021-08-07","#416CCE"],["2021-08-09","#416DCE"],["2021-08-10","#416DCE"],["2021-08-12","#416ECE"],["2021-08-13","#416FCE"],["2021-08-16","#4270CE"],["2021-08-17","#4271CE"],["2021-08-18","#4271CE"],["2021-08-19","#4271CE"],["2021-08-22","#4273CE"],["2021-08-25","#4374CD"],["2021-08-27","#4375CD"],["2021-09-02","#4378CD"],["2021-09-03","#4379CD"],["2021-09-13","#447DCC"],["2021-09-20","#4580CA"],["2021-09-23","#4681C9"],["2021-09-24","#4682C9"],["2021-09-27","#4783C8"],["2021-09-29","#4783C8"],["2021-09-30","#4784C8"],["2021-10-04","#4885C7"],["2021-10-08","#4887C6"],["2021-10-11","#4988C5"],["2021-10-12","#4988C5"],["2021-10-18","#4A8BC3"],["2021-10-22","#4A8CC2"],["2021-10-25","#4B8DC2"],["2021-10-27","#4B8EC1"],["2021-10-28","#4B8FC1"],["2021-11-02","#4C91C0"],["2021-11-04","#4C91BF"],["2021-11-05","#4D92BF"],["2021-11-17","#4F96BC"],["2021-11-18","#4F96BB"],["2021-11-19","#4F97BB"],["2021-11-23","#5098BA"],["2021-11-24","#5098B9"],["2021-11-25","#5098B9"],["2021-11-29","#5199B7"],["2021-12-03","#529AB6"],["2021-12-07","#539BB4"],["2021-12-08","#539CB4"],["2021-12-10","#539CB3"],["2021-12-13","#549DB2"],["2021-12-14","#549DB2"],["2021-12-17","#559EB1"],["2021-12-19","#559FB0"],["2021-12-21","#569FAF"],["2021-12-22","#56A0AF"],["2021-12-26","#57A1AE"],["2021-12-28","#57A1AD"],["2022-01-01","#58A2AB"],["2022-01-05","#59A3AA"],["2022-01-07","#59A4A9"],["2022-02-16","#63AC99"],["2022-02-23","#65AD96"],["2022-02-25","#66AE96"],["2022-03-16","#6BB18E"],["2022-03-25","#6DB38A"],["2022-03-28","#6EB389"],["2022-03-29","#6FB389"],["2022-03-31","#6FB488"],["2022-04-01","#70B487"],["2022-04-04","#71B486"],["2022-04-06","#71B486"],["2022-04-08","#72B485"],["2022-04-14","#74B582"],["2022-04-19","#75B681"],["2022-04-20","#76B680"],["2022-04-21","#76B680"],["2022-04-29","#79B77D"],["2022-05-01","#79B77C"],["2022-05-03","#7AB77B"],["2022-05-06","#7BB77A"],["2022-05-08","#7CB879"],["2022-05-09","#7CB879"],["2022-05-10","#7CB878"],["2022-05-11","#7DB878"],["2022-05-12","#7DB878"],["2022-05-14","#7DB877"],["2022-05-18","#7FB975"],["2022-05-19","#7FB975"],["2022-05-21","#80B974"],["2022-05-22","#80B974"],["2022-05-23","#80B973"],["2022-05-25","#81BA73"],["2022-05-29","#82BA71"],["2022-05-30","#83BA71"],["2022-05-31","#83BA70"],["2022-06-01","#83BA70"],["2022-06-02","#84BA70"],["2022-06-03","#84BA6F"],["2022-06-04","#84BA6F"],["2022-06-05","#85BA6F"],["2022-06-06","#85BA6E"],["2022-06-07","#86BB6E"],["2022-06-08","#86BB6E"],["2022-06-09","#86BB6D"],["2022-06-10","#87BB6D"],["2022-06-11","#87BB6D"],["2022-06-12","#87BB6C"],["2022-06-13","#88BB6C"],["2022-06-14","#88BB6C"],["2022-06-18","#8ABB6B"],["2022-06-23","#8BBB69"],["2022-06-24","#8CBB69"],["2022-06-25","#8CBB68"],["2022-06-26","#8DBC68"],["2022-07-01","#8EBC66"],["2022-07-02","#8FBC66"],["2022-07-03","#8FBC66"],["2022-07-07","#91BC65"],["2022-07-08","#91BC64"],["2022-07-09","#91BC64"],["2022-07-12","#92BC63"],["2022-07-14","#93BC62"],["2022-07-15","#93BD62"],["2022-07-16","#94BD62"],["2022-07-20","#95BD60"],["2022-07-21","#96BD60"],["2022-07-22","#96BD60"],["2022-07-24","#97BD5F"],["2022-07-25","#97BD5F"],["2022-07-27","#98BD5E"],["2022-07-28","#98BD5E"],["2022-07-29","#99BD5D"],["2022-07-30","#99BD5D"],["2022-08-01","#9ABD5D"],["2022-08-03","#9ABE5C"],["2022-08-06","#9CBE5B"],["2022-08-08","#9CBE5B"],["2022-08-09","#9DBE5A"],["2022-08-10","#9DBE5A"],["2022-08-12","#9EBE5A"],["2022-08-15","#9FBE59"],["2022-08-16","#9FBE59"],["2022-08-18","#A0BE58"],["2022-08-19","#A0BE58"],["2022-08-21","#A1BE58"],["2022-08-22","#A2BE57"],["2022-08-23","#A2BE57"],["2022-08-24","#A2BE57"],["2022-08-25","#A3BE57"],["2022-08-26","#A3BE56"],["2022-08-27","#A3BE56"],["2022-08-28","#A4BE56"],["2022-08-29","#A4BE56"],["2022-08-30","#A5BE56"],["2022-08-31","#A5BE55"],["2022-09-02","#A6BE55"],["2022-09-03","#A6BE55"],["2022-09-04","#A6BE54"],["2022-09-05","#A7BE54"],["2022-09-06","#A7BE54"],["2022-09-07","#A8BE54"],["2022-09-09","#A8BD53"],["2022-09-12","#AABD53"],["2022-09-14","#AABD52"],["2022-09-15","#ABBD52"],["2022-09-16","#ABBD52"],["2022-09-17","#ABBD51"],["2022-09-18","#ACBD51"],["2022-09-19","#ACBD51"],["2022-09-20","#ADBD51"],["2022-09-21","#ADBD50"],["2022-09-22","#ADBD50"],["2022-09-23","#AEBD50"],["2022-09-24","#AEBD50"],["2022-09-25","#AEBD50"],["2022-09-29","#B0BD4F"],["2022-09-30","#B0BD4E"],["2022-10-03","#B1BD4E"],["2022-10-05","#B2BD4D"],["2022-10-05","#B3BD4D"],["2022-10-07","#B4BD4C"],["2022-10-11","#B5BD4C"],["2022-10-12","#B5BD4C"],["2022-10-13","#B6BD4B"],["2022-10-14","#B6BD4B"],["2022-10-15","#B7BD4B"],["2022-10-16","#B7BD4B"],["2022-10-17","#B7BD4B"],["2022-10-19","#B8BC4B"],["2022-10-20","#B8BC4A"],["2022-10-21","#B9BC4A"],["2022-10-22","#B9BC4A"],["2022-10-23","#B9BC4A"],["2022-10-24","#BABC4A"],["2022-10-31","#BCBB49"],["2022-11-01","#BCBB49"],["2022-11-02","#BDBB48"],["2022-11-03","#BDBB48"],["2022-11-04","#BDBB48"],["2022-11-05","#BEBB48"],["2022-11-06","#BEBB48"],["2022-11-08","#BFBB48"],["2022-11-09","#BFBB47"],["2022-11-10","#C0BB47"],["2022-11-12","#C0BA47"],["2022-11-13","#C1BA47"],["2022-11-14","#C1BA47"],["2022-11-15","#C1BA47"],["2022-11-16","#C2BA46"],["2022-11-20","#C3BA46"],["2022-11-22","#C4BA45"],["2022-11-23","#C4B945"],["2022-11-25","#C5B945"],["2022-11-26","#C5B945"],["2022-11-28","#C6B945"],["2022-11-29","#C6B944"],["2022-11-30","#C6B944"],["2022-12-01","#C7B944"],["2022-12-02","#C7B944"],["2022-12-03","#C8B944"],["2022-12-04","#C8B944"],["2022-12-06","#C9B843"],["2022-12-07","#C9B843"],["2022-12-10","#CAB843"],["2022-12-14","#CBB742"],["2022-12-15","#CBB742"],["2022-12-16","#CCB742"],["2022-12-18","#CCB742"],["2022-12-21","#CDB642"],["2022-12-22","#CDB642"],["2022-12-23","#CEB641"],["2022-12-24","#CEB641"],["2022-12-25","#CEB541"],["2022-12-27","#CFB541"],["2022-12-29","#CFB541"],["2022-12-30","#CFB441"],["2022-12-31","#D0B441"],["2023-01-01","#D0B441"],["2023-01-03","#D1B440"],["2023-01-06","#D1B340"],["2023-01-07","#D2B340"],["2023-01-09","#D2B240"],["2023-01-12","#D3B240"],["2023-01-13","#D3B23F"],["2023-01-14","#D3B13F"],["2023-01-15","#D4B13F"],["2023-01-21","#D5B03F"],["2023-01-23","#D6B03F"],["2023-01-24","#D6AF3E"],["2023-01-25","#D6AF3E"],["2023-01-26","#D7AF3E"],["2023-01-27","#D7AF3E"],["2023-01-28","#D7AF3E"],["2023-01-29","#D7AE3E"],["2023-01-30","#D8AE3E"],["2023-01-31","#D8AE3E"],["2023-02-02","#D9AE3E"],["2023-02-03","#D9AE3E"],["2023-02-08","#DAAD3D"],["2023-02-09","#DAAC3D"],["2023-02-10","#DBAC3D"],["2023-02-11","#DBAC3D"],["2023-02-12","#DBAC3D"],["2023-02-14","#DCAB3C"],["2023-02-19","#DDAA3C"],["2023-02-21","#DDA93C"],["2023-02-23","#DDA93C"],["2023-02-24","#DDA83C"],["2023-02-26","#DEA83C"],["2023-02-28","#DEA73B"],["2023-03-02","#DEA63B"],["2023-03-03","#DEA63B"],["2023-03-05","#DFA53B"],["2023-03-07","#DFA43B"],["2023-03-09","#DFA43B"],["2023-03-10","#DFA33B"],["2023-03-11","#E0A33B"],["2023-03-16","#E0A13A"],["2023-03-18","#E1A13A"],["2023-03-19","#E1A03A"],["2023-03-20","#E1A03A"],["2023-03-21","#E1A03A"],["2023-03-22","#E19F3A"],["2023-03-23","#E19F3A"],["2023-03-24","#E19F39"],["2023-03-27","#E29E39"],["2023-03-28","#E29D39"],["2023-03-29","#E29D39"],["2023-03-30","#E29D39"],["2023-03-31","#E39C39"],["2023-04-03","#E39B39"],["2023-04-04","#E39B39"],["2023-04-05","#E39B39"],["2023-04-07","#E49A38"],["2023-04-08","#E49A38"],["2023-04-11","#E49838"],["2023-04-12","#E49838"],["2023-04-13","#E49838"],["2023-04-14","#E59738"],["2023-04-17","#E59638"],["2023-04-18","#E59638"],["2023-04-19","#E59637"],["2023-04-20","#E59537"],["2023-04-21","#E69537"],["2023-04-22","#E69537"],["2023-04-23","#E69437"],["2023-04-24","#E69437"],["2023-04-25","#E69337"],["2023-04-26","#E69337"],["2023-04-28","#E69237"],["2023-05-01","#E69036"],["2023-05-03","#E68F36"],["2023-05-04","#E68F36"],["2023-05-05","#E68E36"],["2023-05-06","#E68E36"],["2023-05-07","#E68D36"],["2023-05-08","#E68D36"],["2023-05-11","#E68B35"],["2023-05-22","#E68634"],["2023-05-23","#E68534"],["2023-05-24","#E68534"],["2023-05-25","#E68434"],["2023-05-26","#E68434"],["2023-05-29","#E68234"],["2023-05-30","#E68234"],["2023-05-31","#E68134"],["2023-06-01","#E68133"],["2023-06-02","#E68033"],["2023-06-06","#E67E33"],["2023-06-07","#E67E33"],["2023-06-08","#E67D33"],["2023-06-09","#E67D33"],["2023-06-10","#E67C33"],["2023-06-11","#E67C32"],["2023-06-12","#E67B32"],["2023-06-13","#E67B32"],["2023-06-14","#E67A32"],["2023-06-20","#E67732"],["2023-06-26","#E67431"],["2023-06-28","#E67331"],["2023-06-29","#E67331"],["2023-06-30","#E67231"],["2023-07-09","#E56C30"],["2023-07-10","#E56C2F"],["2023-07-11","#E56B2F"],["2023-07-13","#E56A2F"],["2023-07-14","#E5692F"],["2023-07-17","#E4672F"],["2023-07-19","#E4662E"],["2023-07-23","#E4642E"],["2023-07-24","#E4632E"],["2023-07-25","#E4622E"],["2023-07-26","#E3622D"],["2023-07-27","#E3612D"],["2023-07-28","#E3602D"],["2023-08-02","#E35D2D"],["2023-08-04","#E35C2C"],["2023-08-06","#E25B2C"],["2023-08-07","#E25A2C"],["2023-08-10","#E2582C"],["2023-08-17","#E1542B"],["2023-08-22","#E1512A"],["2023-08-23","#E1502A"],["2023-08-24","#E1502A"],["2023-08-25","#E14F2A"],["2023-08-30","#E04C29"],["2023-08-31","#E04B29"],["2023-09-01","#E04B29"],["2023-09-04","#E04929"],["2023-09-05","#E04828"],["2023-09-06","#DF4728"],["2023-09-07","#DF4728"],["2023-09-10","#DF4528"],["2023-09-11","#DF4428"],["2023-09-17","#DF4127"],["2023-09-21","#DE3E27"],["2023-09-22","#DE3D27"],["2023-09-24","#DE3C26"],["2023-09-26","#DE3B26"],["2023-09-27","#DE3A26"],["2023-09-29","#DE3926"],["2023-10-04","#DD3625"],["2023-10-12","#DD3124"],["2023-10-13","#DD3024"],["2023-10-15","#DC2F24"],["2023-10-16","#DC2E24"],["2023-10-17","#DC2E24"],["2023-10-18","#DC2D24"],["2023-11-02","#551EA4"],["2023-11-12","#4C24AF"],["2023-11-14","#4B26B1"],["2023-11-17","#4928B4"],["2023-11-21","#472CB7"],["2023-11-24","#462FBA"],["2023-11-27","#4432BD"],["2023-11-28","#4333BE"],["2023-11-29","#4334BF"],["2023-11-30","#4235C0"],["2023-12-01","#4236C1"],["2023-12-02","#4137C2"],["2023-12-03","#4138C3"],["2023-12-17","#3F49C9"],["2023-12-20","#3F4CCB"],["2023-12-21","#3F4ECB"],["2024-01-08","#3F63CF"],["2024-01-09","#4064CF"],["2024-01-10","#4065CF"],["2024-01-11","#4066CF"],["2024-01-16","#416CCE"],["2024-01-21","#4272CE"],["2024-01-22","#4273CE"],["2024-01-31","#447DCC"],["2024-02-01","#447ECC"],["2024-02-02","#457FCB"],["2024-02-04","#4680CA"],["2024-02-12","#4887C5"],["2024-02-20","#4B8FC1"],["2024-02-22","#4C90C0"],["2024-03-01","#4F97BB"],["2024-03-04","#5199B8"],["2024-03-05","#5199B7"],["2024-03-06","#529AB6"],["2024-03-09","#539CB4"],["2024-03-14","#569FB0"],["2024-03-17","#57A1AD"],["2024-03-19","#58A2AB"],["2024-03-20","#58A3AB"],["2024-03-25","#5BA6A6"],["2024-03-26","#5BA7A5"],["2024-03-29","#5DA8A3"],["2024-04-02","#60AA9F"],["2024-04-03","#60AA9E"],["2024-04-04","#61AB9D"],["2024-04-15","#68AF93"],["2024-04-16","#68B092"],["2024-04-18","#6AB090"],["2024-05-15","#7DB877"],["2024-05-16","#7EB876"],["2024-05-17","#7FB975"],["2024-05-18","#7FB975"],["2024-05-28","#87BB6C"],["2024-05-29","#88BB6C"],["2024-05-30","#89BB6B"],["2024-05-31","#8ABB6A"],["2024-06-04","#8DBC67"],["2024-06-05","#8EBC67"],["2024-06-07","#90BC65"],["2024-06-08","#91BC64"],["2024-06-09","#92BC64"],["2024-06-10","#92BC63"],["2024-06-13","#95BD61"],["2024-06-14","#96BD60"],["2024-06-17","#98BD5E"],["2024-06-29","#A3BE57"],["2024-07-01","#A5BE56"],["2024-07-03","#A6BE55"],["2024-07-10","#ACBD51"],["2024-07-12","#AEBD50"],["2024-07-13","#AFBD4F"],["2024-08-07","#C4BA46"],["2024-08-08","#C4B945"],["2024-08-12","#C8B944"],["2024-08-14","#C9B843"],["2024-08-15","#CAB843"],["2024-08-16","#CBB842"],["2024-08-17","#CBB742"],["2024-08-20","#CDB642"],["2024-08-24","#D0B441"],["2024-08-27","#D2B340"],["2024-09-05","#D7AF3E"]]},{"key":"designation_recency","title":"Designation recency","type":"categorical"},{"key":"Nextclade_pango","title":"Nextclade Pango Lineage","type":"categorical"},{"key":"partiallyAliased","title":"Unaliased Pango Lineage","type":"categorical"},{"key":"clade_who","title":"WHO name","type":"categorical","scale":[["Alpha","#403CC5"],["Beta","#4067CF"],["Gamma","#4A8BC3"],["Delta","#5AA4A9"],["Epsilon","#6FB488"],["Eta","#8BBB69"],["Theta","#A9BD53"],["Iota","#C7B944"],["Kappa","#DDA93C"],["Lambda","#E68A35"],["Mu","#E35C2C"],["Omicron","#DB2823"]]},{"key":"clade_nextstrain","title":"Nextstrain clade name","type":"categorical","scale":[["21L","#5E1D9D"],["22A","#4929B4"],["22B","#403FC6"],["22C","#3E59CF"],["22D","#4272CE"],["22E","#4887C6"],["22F","#5199B8"],["23A","#5BA7A6"],["23B","#69B091"],["23C","#78B67E"],["23D","#89BB6B"],["23E","#9BBE5B"],["23F","#AEBD50"],["23G","#C0BB47"],["23H","#D0B441"],["23I","#DDAA3C"],["24A","#E49938"],["24B","#E68234"],["24C","#E4672E"],["24D","#DF4728"],["24E","#DB2823"]]},{"key":"clade_display","title":"Display clade name","type":"categorical"},{"key":"immune_escape","title":"RBD immune escape score","type":"continuous"},{"key":"ace2_binding","title":"ACE2 affinity score","type":"continuous"},{"key":"qc.overallScore","title":"Overall QC score","type":"continuous"},{"key":"frameShifts","title":"All frame shifts","type":"categorical"},{"key":"qc.frameShifts.frameShifts","title":"Unusual frame shifts","type":"categorical"},{"key":"qc.frameShifts.totalFrameShifts","title":"Total unusual frame shifts","type":"categorical"},{"key":"qc.stopCodons.totalStopCodons","title":"Total stop codons","type":"categorical"},{"key":"totalAminoacidSubstitutions","title":"Total amino acid substitutions","type":"continuous"},{"key":"totalAminoacidDeletions","title":"Total amino acid deletions","type":"continuous"},{"key":"placement_prior","title":"Placement Prior (log10)","type":"continuous"}],"filters":["new_node","clade_membership","Nextclade_pango","partiallyAliased","clade_who","clade_display","designation_date","designation_recency"],"panels":["tree","entropy"],"extensions":{"nextclade":{"clade_node_attrs":[{"name":"Nextclade_pango","displayName":"Pango lineage (Nextclade)","description":"Pango lineage as inferred by Nextclade from the nearest neighbour in the reference tree. 98% accurate for recent sequences, for higher accuracy use dedicated pangolin software in UShER or pangoLEARN mode. Recombinants may get (wrongly) assigned to a designated recombinant lineage if they have similar breakpoints.","hideInWeb":false},{"name":"partiallyAliased","displayName":"Unaliased","description":"Partially aliased reconstructed Pango lineage","skipAsReference":true,"hideInWeb":true},{"name":"clade_nextstrain","displayName":"Nextstrain Clade","description":"Nextstrain Clade","skipAsReference":true,"hideInWeb":true},{"name":"clade_who","displayName":"WHO name","description":"Greek letter WHO name","skipAsReference":true,"hideInWeb":false},{"name":"clade_display","displayName":"Clade display name","description":"Combination of Nextstrain clade and Pango lineage","skipAsReference":true,"hideInWeb":true}],"ref_nodes":{"default":"__root__","search":[{"name":"JN.1","displayName":"JN.1 (24A)","description":"One of the variants recommended for the 2024/2025 COVID-19 vaccine","criteria":[{"qry":[{"clade": ["23I","24A","24B","24C","24D","24E","recombinant"]]}],"node":[{"name":["JN.1"]}]}]},{"name":"XBB.1.5","displayName":"XBB.1.5 (23A)","description":"Variant recommended for the 2023/2024 COVID-19 vaccine","criteria":[{"qry":[{"clade":["22F","23A","23B","23C","23D","23E","23F","23G","recombinant"]}],"node":[{"name":["XBB.1.5"]}]}]}]},"placement_mask_ranges":[{"begin":0,"end":50},{"begin":29850,"end":29902}]}}},"tree":{"name":"NODE_0000000","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{},"labels":{"clade":"19A"}},"children":[{"name":"B","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{}}},{"name":"rec_parent","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{"ORF6":["D61L"],"S":["T19I"]},"labels":{"aa":"ORF6: D61L; S: T19I","spike_mutations":"T19I"}},"children":[{"name":"XAA","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A1610G","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C8247T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12445T","C12880T","C14408T","C15714T","C17410T","A18163G","A19356G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["N269D"],"nsp3":["K38R","S1265-","L1266I","S1843F"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: N269D; nsp3: K38R, S1265-, L1266I, S1843F; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAB","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.443575382232666}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17010T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XA","node_attrs":{"div":33,"Nextclade_pango":{"value":"XA"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T445C","T2019C","C3037T","C4999T","C6286T","C8090T","C9430T","A10323G","C13945T","C14408T","G20410A","G21255C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23208T","C23271A","A23403G","C23604A","C23709T","T24506G","G24914C","G25855T","C27972T","G28048T","A28095T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"N":["D3L","R203K","G204R","S235F"],"ORF3a":["D155Y"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","K68*","Y73C"],"S":["I19T","H69-","V70-","Y144-","N501Y","T549I","A570D","D614G","P681H","T716I","S982A","D1118H"],"nsp12":["P169S","P323L"],"nsp15":["E264K"],"nsp2":["M405T"],"nsp3":["L1791F"],"nsp5":["K90R"]},"labels":{"aa":"N: D3L, R203K, G204R, S235F; ORF3a: D155Y; ORF6: L61D; ORF8: Q27*, R52I, K68*, Y73C; S: I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H; nsp12: P169S, P323L; nsp15: E264K; nsp2: M405T; nsp3: L1791F; nsp5: K90R","spike_mutations":"I19T, H69-, V70-, Y144-, N501Y, T549I, A570D, D614G, P681H, T716I, S982A, D1118H"}}},{"name":"XAF","node_attrs":{"div":65,"Nextclade_pango":{"value":"XAF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","G11516T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","T181I","V182F"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, T181I, V182F","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAE","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.17270999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","G4975A","A6390C","C9344T","A9424G","C9534T","C9803T","C9866T","C10029T","C10198T","G10447A","C10449A","C11249T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C","T29748C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","E1224A"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["R93C","S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, E1224A; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: R93C, S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAD","node_attrs":{"div":66,"Nextclade_pango":{"value":"XAD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.857146263122559}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","A1250G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28877T","G28878C","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["T149A"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: T149A; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.851975917816162}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15720T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25731T","C25810T","C26028T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["L140F"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: L140F; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAJ","node_attrs":{"div":72,"Nextclade_pango":{"value":"XAJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.647030830383301}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11674T","C12880T","C14408T","T15009C","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","A23535G","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N658S","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XAH","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.717092990875244}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","G17242T","C17410T","A18163G","C18246T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33G","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["A336S","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33G, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: A336S, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAG","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.28093999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.583486557006836}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C2857T","C3037T","T5386G","C5585A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12334G","C12880T","C14408T","C15714T","C17410T","C17502T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S373P","S375F","T376A","D405N","R408S","K417N","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","L956I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, L956I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S373P, S375F, T376A, D405N, R408S, K417N, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAK","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15166"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3037714005953052"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4927T","T5386G","C7834T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12049T","C12880T","C14408T","C15240T","A18163G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","A22001G","T22200G","G22578A","G22599A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22942G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24863T","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","H69-","V70-","G142D","K147E","V213G","G339D","R346K","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N460K","S477N","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","H1101Y"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y; nsp1: S135R; nsp12: P323L; nsp14: I42V; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"I19T, H69-, V70-, G142D, K147E, V213G, G339D, R346K, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, H1101Y"}}},{"name":"XAL","node_attrs":{"div":61,"Nextclade_pango":{"value":"XAL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","A2865G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","G21586T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L8F","L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","E49G","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, E49G, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L8F, L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, N764K, D796Y, Q954H, N969K"}}},{"name":"XAM","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75567"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11514T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","T181I"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, T181I","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAN","node_attrs":{"div":70,"Nextclade_pango":{"value":"XAN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081246852874756}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7973A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","C17822T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","T27696C","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29666T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["L37F"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C","P529L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","L1752M"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: L37F; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C, P529L; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, L1752M; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAR","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.447500705718994}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21796T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","R78S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, R78S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAP","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.9306466579437256}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C5407A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAQ","node_attrs":{"div":63,"Nextclade_pango":{"value":"XAQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C4586T","T5386G","G6513-","T6514-","T6515-","G8393A","C9857T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23779T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAS","node_attrs":{"div":68,"Nextclade_pango":{"value":"XAS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.466667652130127}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAT","node_attrs":{"div":66,"Nextclade_pango":{"value":"XAT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","C10277T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19317T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25810T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["L140F","T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["L75F","P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: L140F, T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: L75F, P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAV","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.716916561126709}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C6606T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C15960T","G17278T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","T27438C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["V348L","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","S1296F"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: V348L, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, S1296F; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAW","node_attrs":{"div":96,"Nextclade_pango":{"value":"XAW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91409"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.274687314409391"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C335T","G569A","T689C","G1048T","G1125A","C1973T","C3037T","G3246A","G4181T","G4561A","C5052T","C5167T","G6149A","C6402T","T6640C","C7124T","G7427A","C8986T","G9053T","T9676C","C10029T","A10323G","A11201G","G11330A","A11332G","C11866T","C13806T","C13994T","C14408T","C14585T","G15451A","C16466T","C17304T","C17550T","A17973G","G18525A","C19220T","C19290T","C20402T","G20493A","C21575T","C21618G","C21636T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","T22283C","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","G22578A","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","T22942A","G22992A","C22995A","A23013C","T23042C","A23055G","A23063T","T23075C","C23114T","A23403G","C23525T","C23604A","C23854A","G23948T","G24145A","A24424T","T24469A","C25000T","C25584T","A25592G","C26060T","C26270T","C26537T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28562A","G28646A","C28849T","C28873T","G28881T","G28916T","G29402T","C29635T","G29742T"],"E":["T9I"],"M":["Q19E","A63T"],"N":["D63G","G97S","A125T","R203M","G215C","D377Y"],"ORF3a":["K67R","T223I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["L5F","I19R","P25L","E156-","F157-","R158G","N211-","L212I","L242-","A243-","G339D","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","N460K","S477N","T478K","E484A","S494P","Q498R","N501Y","Y505H","D614G","H655Y","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["R24C","E102K","S142P"],"nsp12":["A185V","P323L","A382V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp15":["S261L"],"nsp2":["K81N","R107K"],"nsp3":["S176N","A488S","P778L","D1144N","P1228L","P1469S","A1570T"],"nsp4":["V167L","T492I"],"nsp5":["K90R"],"nsp6":["T77A","V120M"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: D63G, G97S, A125T, R203M, G215C, D377Y; ORF3a: K67R, T223I; ORF8: D119-, F120-; ORF9b: T60A; S: L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K; nsp1: R24C, E102K, S142P; nsp12: A185V, P323L, A382V, G671S; nsp13: P77L; nsp14: A394V; nsp15: S261L; nsp2: K81N, R107K; nsp3: S176N, A488S, P778L, D1144N, P1228L, P1469S, A1570T; nsp4: V167L, T492I; nsp5: K90R; nsp6: T77A, V120M","spike_mutations":"L5F, I19R, P25L, E156-, F157-, R158G, N211-, L212I, L242-, A243-, G339D, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, N460K, S477N, T478K, E484A, S494P, Q498R, N501Y, Y505H, D614G, H655Y, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAU","node_attrs":{"div":70,"Nextclade_pango":{"value":"XAU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.173168659210205}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","T17407C","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","A24433G","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XAZ","node_attrs":{"div":67,"Nextclade_pango":{"value":"XAZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.731168746948242}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1912T","C2232T","C2790T","C3037T","C3317T","T3358C","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A476V"],"nsp3":["T24I","P200S","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A476V; nsp3: T24I, P200S, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XB","node_attrs":{"div":29,"Nextclade_pango":{"value":"XB"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-11-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.699317693710327}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C3688T","C3884T","C6633T","A7142G","A9614G","C9693T","A9754C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14408T","G15451A","C16466T","C21057T","T21615G","C21846T","A22036C","A23403G","C23604A","C23625T","T23765G","C24442T","C24642T","G26158-","T26159-","T26160-","A26161-","C26222T","C27389T","C27769T","G28048A","A28271-","A28330G","C28854T","A28910T"],"N":["S194L","N213Y"],"ORF3a":["V256-","N257-","P258I","M260I","E261I","P262I","T269I","P274I","L275I"],"ORF6":["L61D"],"ORF7b":["S5L"],"ORF8":["R52K"],"ORF9b":["D16G"],"S":["L18R","I19T","T95I","R158S","D614G","P681H","A688V","S735A","T1027I"],"nsp12":["P323L","G671S"],"nsp13":["P77L"],"nsp3":["P389S","A1305V","S1475G"],"nsp4":["T354A","A380V","R400S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: S194L, N213Y; ORF3a: V256-, N257-, P258I, M260I, E261I, P262I, T269I, P274I, L275I; ORF6: L61D; ORF7b: S5L; ORF8: R52K; ORF9b: D16G; S: L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I; nsp12: P323L, G671S; nsp13: P77L; nsp3: P389S, A1305V, S1475G; nsp4: T354A, A380V, R400S; nsp6: S106-, G107-, F108-","spike_mutations":"L18R, I19T, T95I, R158S, D614G, P681H, A688V, S735A, T1027I"}}},{"name":"XBA","node_attrs":{"div":70,"Nextclade_pango":{"value":"XBA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20215999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.29808642936638835"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4181T","C6402T","C7124T","C8595T","C8986T","G9053T","C10029T","A11201G","A11332G","G13812T","C14408T","C14790T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","A22991G","G22992A","C22995A","A23013C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","T26767C","G26959A","T27638C","A27663T","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","C28311T","A28461G","G28881A","G28882A","G28883C","G29402T","G29742T"],"M":["I82T","R146H"],"N":["P13L","D63G","R203K","G204R","D377Y"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["V82A","Q90H","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["P10S","T60A"],"S":["L18F","I19R","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477D","T478K","E484A","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","T1117I"],"nsp1":["S135R"],"nsp12":["M124I","P323L","A529V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["T24I","A488S","P1228L","P1469S"],"nsp4":["T14I","V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T, R146H; N: P13L, D63G, R203K, G204R, D377Y; ORF3a: S26L; ORF6: L61D; ORF7a: V82A, Q90H, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: P10S, T60A; S: L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I; nsp1: S135R; nsp12: M124I, P323L, A529V, G671S; nsp13: P77L; nsp14: A394V; nsp3: T24I, A488S, P1228L, P1469S; nsp4: T14I, V167L, T492I; nsp6: T77A","spike_mutations":"L18F, I19R, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477D, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, T1117I"}}},{"name":"XBD","node_attrs":{"div":82,"Nextclade_pango":{"value":"XBD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBE","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.574315547943115}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27800T","C27807T","C27889T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["T127N","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: T127N, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBH","node_attrs":{"div":80,"Nextclade_pango":{"value":"XBH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.37244999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C7528T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13730T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25157A","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28881A","G28882A","G28883C","A29510C","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","T29758C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","D1199N"],"nsp1":["S135R"],"nsp12":["A97V","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N; nsp1: S135R; nsp12: A97V, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N"}}},{"name":"XBG","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10116T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11665T","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","A24676G","C25000T","C25584T","C26060T","T26180C","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I","I263T"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["T21I","P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I, I263T; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: T21I, P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBN","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","A2863G","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","A19459G","C19554T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C25638T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","I474V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, I474V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBM","node_attrs":{"div":74,"Nextclade_pango":{"value":"XBM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19812G","G19891A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","T22304A","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23202T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","G24620T","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","A27038G","C27549T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29868A"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","Y248N","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","T547I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","A1020S"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["D91N","T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: D91N, T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, T547I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, A1020S"}}},{"name":"XBP","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G204A","C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7303T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C12952T","C13965T","C14408T","C15277T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","T23773C","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","H613Y","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, H613Y, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBR","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1093T","G1440A","A1964G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","A5844G","C8597T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12440C","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21077T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22855T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","G25471C","C25553T","T25569C","C25584T","G26031A","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["D27H","A54V","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["T140I"],"nsp2":["G212D","I387V"],"nsp3":["T24I","S403L","G489S","P822S","K1042R"],"nsp4":["L15F","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: D27H, A54V, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: T140I; nsp2: G212D, I387V; nsp3: T24I, S403L, G489S, P822S, K1042R; nsp4: L15F, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBQ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G14829T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","M463I","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, M463I, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBS","node_attrs":{"div":82,"Nextclade_pango":{"value":"XBS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T670G","C2790T","C2842T","C3037T","C3796T","C3809T","C3927T","G4184A","C4321T","C4586T","C5183T","C6982T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","T20748C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["G82-","H83-","V84-","M85V","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","L364F","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: G82-, H83-, V84-, M85V, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, L364F, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBT","node_attrs":{"div":81,"Nextclade_pango":{"value":"XBT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64255"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5037920175803539"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C829T","C1627T","C2790T","C3037T","A3207G","G4184A","G4288A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","T22917G","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","G23587A","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","L452R","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","D163G","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, D163G, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBV","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32919999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8040G","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12310A","C12880T","C14408T","C15714T","G15957T","C16616A","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123A","A23223G","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24170G","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","P521T","E554G","D614G","H655Y","N679K","P681H","N764K","D796Y","I870V","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["T127N","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","D1774G"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: T127N, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, D1774G; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, P521T, E554G, D614G, H655Y, N679K, P681H, N764K, D796Y, I870V, Q954H, N969K"}}},{"name":"XBW","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22612C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","G29260A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBU","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74825"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["A51V","S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: A51V, S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XBY","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5812T","C9344T","A9424G","C9532T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","G19962T","A20055G","C21054T","G21305A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T28137A","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["S82T"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["R216H"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: S82T; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: R216H; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XC","node_attrs":{"div":39,"Nextclade_pango":{"value":"XC"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5239T","T5514C","C6402T","C7124T","C8986T","G9053T","C10029T","A11201G","A11332G","C14408T","G15451A","C16466T","C19220T","C21618G","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22081T","T22917G","C22995A","A23403G","C23604G","G24410A","C25469T","T26767C","G27390T","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","G28881A","G28882A","G28883C","C28977T"],"M":["I82T"],"N":["D3L","R203K","G204R","S235F"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF8":["Q27*","R52I","Y73C"],"S":["I19R","T95I","G142D","E156-","F157-","R158G","Q173H","L452R","T478K","D614G","P681R","D950N"],"nsp12":["P323L","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["A488S","V932A","P1228L","P1469S"],"nsp4":["V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T; N: D3L, R203K, G204R, S235F; ORF3a: S26L; ORF6: L61D; ORF8: Q27*, R52I, Y73C; S: I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N; nsp12: P323L, G671S; nsp13: P77L; nsp14: A394V; nsp3: A488S, V932A, P1228L, P1469S; nsp4: V167L, T492I; nsp6: T77A","spike_mutations":"I19R, T95I, G142D, E156-, F157-, R158G, Q173H, L452R, T478K, D614G, P681R, D950N"}}},{"name":"XBZ","node_attrs":{"div":80,"Nextclade_pango":{"value":"XBZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","T2954C","C3037T","G4184A","C4321T","C6040T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","G12160A","C12880T","T14257C","C14408T","C15714T","G16935A","A17039G","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T21992-","A21993-","T21994-","T22200G","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","C22858T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","C23086T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26428T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","C28770T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","V62F"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","T166I","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","Y144-","V213G","G339D","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["Y273H","P323L"],"nsp13":["M233I","N268S","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, V62F; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, T166I, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: Y273H, P323L; nsp13: M233I, N268S, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, Y144-, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCA","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74825"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2062T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C5192T","C5748A","C9344T","A9424G","T9454C","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","C11124T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","T13324C","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19017T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21893A","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","C22747T","G22775A","A22786C","G22813T","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","C23595T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","T25975C","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","T29760-","A29761-","C29762-","A29763-","G29764-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["S195P","T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","D111N","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","T678I","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S","T1010N"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["A51V","S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: S195P, T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S, T1010N; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: A51V, S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, D111N, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, T678I, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCC","node_attrs":{"div":97,"Nextclade_pango":{"value":"XCC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1545T","C2790T","C3037T","C3796T","C3857A","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A247V"],"nsp3":["T24I","Q380K","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A247V; nsp3: T24I, Q380K, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCB","node_attrs":{"div":75,"Nextclade_pango":{"value":"XCB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.41968"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","A11126G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12160A","G12311A","C12880T","C14408T","C14724T","C15714T","C17410T","A18163G","G18651A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21987A","T22200G","G22302-","T22303-","T22304-","T22348A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","A22893C","T22917G","T22942A","G22992A","C22995A","A23013C","T23018G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27600T","C27807T","C27889T","A28271T","T28282C","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","H69-","V70-","G142D","V213G","S247-","Y248N","G339D","S371F","S373P","S375F","T376A","D405N","R408S","N440K","K444T","L452R","N460K","S477N","T478K","E484A","F486V","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["M52V","S106-","G107-","F108-"],"nsp8":["A74T"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: M52V, S106-, G107-, F108-; nsp8: A74T","spike_mutations":"L24-, P25-, P26-, A27S, H69-, V70-, G142D, V213G, S247-, Y248N, G339D, S371F, S373P, S375F, T376A, D405N, R408S, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCE","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1931A","C2790T","T2954C","C3037T","G4184A","C4321T","C9344T","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15810T","T15939C","T16342C","C17410T","T17859C","A18163G","G18811A","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22161G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","Y200C","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D258N"],"nsp15":["T112I"],"nsp2":["Q376K"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D258N; nsp15: T112I; nsp2: Q376K; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, Y200C, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCD","node_attrs":{"div":91,"Nextclade_pango":{"value":"XCD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95377"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18006C","A18163G","A19173G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22203A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26529A","C26577G","G26709A","C27807T","C27889T","G28077T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28681T","G28881A","G28882A","G28883C","C29367T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","P365L","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF8":["V62L"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","R214H","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, P365L, S413R; ORF3a: T223I; ORF6: L61D; ORF8: V62L; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, R214H, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCG","node_attrs":{"div":87,"Nextclade_pango":{"value":"XCG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16254"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","G4184A","C4321T","A8170G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCM","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","G331T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","C5730T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T13560C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17661C","T17859C","A18163G","A18879G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","A22115G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24134A","A24373G","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","A29558G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["M1V"],"ORF3a":["A72T","A110V","T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","F157L","N185D","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"],"nsp1":["Q22H","K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","T1004I","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: M1V; ORF3a: A72T, A110V, T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K; nsp1: Q22H, K47R, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, T1004I, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, F157L, N185D, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}}},{"name":"XCL","node_attrs":{"div":101,"Nextclade_pango":{"value":"XCL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C7417T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","C15755G","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23093A","A23403G","C23525T","T23599G","C23604A","C23741T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25046T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","V511I","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","P1162S"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S","S772C"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S; nsp1: K47R, S135R; nsp12: P323L, G671S, S772C; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, V511I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, P1162S"}}},{"name":"XCJ","node_attrs":{"div":97,"Nextclade_pango":{"value":"XCJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C1063T","C2790T","C3037T","G4184A","C4321T","C6312T","A6616G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","G22103C","C22109G","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22843C","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27431T","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28770T","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","T166I","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF7a":["A13V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","G181R","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","T1198I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, T166I, R203K, G204R, S413R; ORF3a: T223I; ORF7a: A13V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, T1198I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, G181R, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCK","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","T2128C","C2790T","C3037T","G3242A","G4184A","C4321T","C5512T","G5720A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11956T","C12789T","C12880T","C12970T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","T18096C","A18163G","A19326G","C19955T","G19962T","A20055G","G20060T","A21137G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","C26270T","G26529A","C26577G","G26709A","G26951C","C27807T","C27889T","C28163A","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28681T","G28881A","G28882A","G28883C","A29510C","T29726-","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","E136D","R203K","G204R","S413R"],"ORF3a":["T223I","V255-","V256-","N257-","P258-"],"ORF6":["L61D"],"ORF8":["C90*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I","S147I"],"nsp16":["K160R"],"nsp3":["T24I","G175S","G489S","G1001S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, E136D, R203K, G204R, S413R; ORF3a: T223I, V255-, V256-, N257-, P258-; ORF6: L61D; ORF8: C90*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I, S147I; nsp16: K160R; nsp3: T24I, G175S, G489S, G1001S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XCP","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","C3622T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11537G","C12789T","C12880T","C14408T","A14634G","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","C19185T","A19326G","C19488T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","I189V"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, I189V; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCR","node_attrs":{"div":106,"Nextclade_pango":{"value":"XCR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C13405T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24373C","A24424T","T24469A","C25000T","A25359G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26708G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K","K1266R"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, K1266R"}}},{"name":"XCQ","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","G6536A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","A13187G","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","A22320G","C22388T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23757T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","T732I","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp10":["I55V"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp10: I55V; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, T732I, N764K, D796Y, Q954H, N969K"}}},{"name":"XCN","node_attrs":{"div":116,"Nextclade_pango":{"value":"XCN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C337T","T670G","C1142T","C1471T","C1513T","C1686T","T2372C","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C7318T","C8782T","G8849A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C14408T","C14790T","T14961C","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21807A","C21910T","G21987A","A22001G","T22016C","C22033A","A22121G","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","T23332C","A23403G","C23453T","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27635T","C27807T","G27915T","C28253T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF7a":["S81L"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","P82H","G142D","K147E","W152R","F157L","K187E","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","P631S","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["L113F","A294V"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["V99M","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF7a: S81L; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: L113F, A294V; nsp3: T24I, S403L, G489S, P822S; nsp4: V99M, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, P82H, G142D, K147E, W152R, F157L, K187E, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, P631S, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCS","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1973T","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12253A","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17010T","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27669G","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","A29221G","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, N969K"}}},{"name":"XCV","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","T5422C","C7044A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27065A","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28182G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","S97G"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","P1442H"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, S97G; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, P1442H; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCU","node_attrs":{"div":99,"Nextclade_pango":{"value":"XCU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8835"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","T670G","C1437T","C2790T","C3037T","T3478C","C4586T","C4893T","C5184T","A5584G","C6196T","G6576T","G7058A","G7091A","A7766G","C9073T","C9891T","C10029T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","A17207G","A19890G","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22116G","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","T23042C","A23055G","A23063T","T23075C","C23123A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","C26606T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28376A","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","A35T","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","N185S","P209L","L212S","D215H","A222V","L242-","A243-","S256L","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","S494P","Q498R","N501Y","Y505H","P521T","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["P77L","T127I","Y324C"],"nsp2":["S211F"],"nsp3":["T24I","T725I","P822L","S1286I","G1447S","V1458I","I1683V"],"nsp4":["A446V","T492I"],"nsp6":["V149A","T181I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, A35T, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: P77L, T127I, Y324C; nsp2: S211F; nsp3: T24I, T725I, P822L, S1286I, G1447S, V1458I, I1683V; nsp4: A446V, T492I; nsp6: V149A, T181I","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, N185S, P209L, L212S, D215H, A222V, L242-, A243-, S256L, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, S494P, Q498R, N501Y, Y505H, P521T, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCY","node_attrs":{"div":104,"Nextclade_pango":{"value":"XCY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XCZ","node_attrs":{"div":112,"Nextclade_pango":{"value":"XCZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","A15436G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","T22609G","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23280T","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26735T","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28519T","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-","T79I"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","T573I","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","M666V","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-, T79I; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: D63N, P323L, M666V, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, T573I, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}}},{"name":"XCW","node_attrs":{"div":102,"Nextclade_pango":{"value":"XCW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4234T","C4321T","T6394C","G6536A","G8863T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","T14305C","C14408T","G15451A","C15714T","C15738T","T15939C","C17410T","T17859C","A18163G","G18636A","T18882C","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","A22190-","T22191-","T22192-","T22200A","A22320G","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","C23123T","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27513T","C27684T","C27807T","G27915T","T28034C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","I210-","V213E","D253G","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","P521S","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["Y289H","P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","G1273S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: Y289H, P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, G1273S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, I210-, V213E, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDB","node_attrs":{"div":97,"Nextclade_pango":{"value":"XDB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.570415496826172}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","G15982A","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S","V848I"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S, V848I; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XD","node_attrs":{"div":65,"Nextclade_pango":{"value":"XD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.029110000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.17203353628663032"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","A1321C","C3037T","G4181T","C6402T","C7124T","C7851T","A8723G","C8986T","G9053T","C10029T","A11201G","A11332G","C14407T","C14408T","T15264C","G15451A","C16466T","C19220T","C21618G","G21641T","C21846T","G21987A","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25667T","G25855T","T26767C","T27638C","C27752T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G28916T","G29402T","G29540A","G29645T","G29742T"],"M":["I82T"],"N":["D63G","R203M","G215C","D377Y"],"ORF10":["V30L"],"ORF3a":["S92L","D155Y"],"ORF6":["L61D"],"ORF7a":["V82A","T120I"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"ORF9b":["T60A"],"S":["I19R","A27S","T95I","G142D","E156-","F157-","R158G","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323F","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp2":["E172D"],"nsp3":["A488S","P1228L","P1469S","A1711V"],"nsp4":["I57V","V167L","T492I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82T; N: D63G, R203M, G215C, D377Y; ORF10: V30L; ORF3a: S92L, D155Y; ORF6: L61D; ORF7a: V82A, T120I; ORF7b: T40I; ORF8: D119-, F120-; ORF9b: T60A; S: I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323F, G671S; nsp13: P77L; nsp14: A394V; nsp2: E172D; nsp3: A488S, P1228L, P1469S, A1711V; nsp4: I57V, V167L, T492I; nsp6: T77A","spike_mutations":"I19R, A27S, T95I, G142D, E156-, F157-, R158G, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XDC","node_attrs":{"div":108,"Nextclade_pango":{"value":"XDC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2110T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","C15763T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21036T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","A28447G","G28881A","G28882A","G28883C","C29386T","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","N55S"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, N55S; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: D63N, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDE","node_attrs":{"div":104,"Nextclade_pango":{"value":"XDE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","T21363C","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","A26612G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29535T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["S122F"],"nsp3":["T24I","G489S","P1261Q","T1465I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["P80L"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: S122F; nsp3: T24I, G489S, P1261Q, T1465I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: P80L","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDF","node_attrs":{"div":107,"Nextclade_pango":{"value":"XDF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","C335T","A405G","T670G","C2790T","C3037T","T3453C","G4184A","C4321T","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A11782G","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","C22570T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","G27666T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","T28382C","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","S37P","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF7a":["E91D"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["R24C","K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","V245A","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, S37P, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF7a: E91D; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: R24C, K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, V245A, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDG","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C547T","T670G","C1758T","C2790T","C3037T","G4184A","C4321T","T4579A","T4690C","T4930C","G5720A","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11518T","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","T16905C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","A23598G","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","A25744G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28754T","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","L161F","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["I118V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679R","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A318V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, L161F, R203K, G204R, S413R; ORF10: S23F; ORF3a: I118V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A318V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679R, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDH","node_attrs":{"div":97,"Nextclade_pango":{"value":"XDH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","T2992A","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","T4744C","C5183T","T7477C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11515C","A12444G","C12880T","C13335T","C14408T","G15451A","C15714T","C17410T","A18163G","C19955T","A20055G","C20235T","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","A22629C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","K356T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp10":["A104V"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","D91E","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp10: A104V; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, D91E, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDJ","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C8947T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","A10861G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","A12397G","T12730A","C12880T","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22033A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G29081T","A29510C","C29625T","A29700G","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","V270L","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","F157L","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, V270L, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, F157L, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDM","node_attrs":{"div":109,"Nextclade_pango":{"value":"XDM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","C22986T","G22992A","C22995T","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24034T","T24046C","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","A475V","S477N","T478I","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["T85A","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp2":["D155G"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: T85A, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp2: D155G; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, A475V, S477N, T478I, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XDL","node_attrs":{"div":110,"Nextclade_pango":{"value":"XDL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2650T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","G13627A","C14408T","G15451A","C15714T","C15738T","T15939C","C15981T","T16342C","A16482C","A16878T","C17410T","T17859C","C17976T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21718T","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","C22480T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22930A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","T24903C","C25000T","C25416T","C25572T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","C28253A","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","F120L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","Q52H","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K","I1114T"],"nsp1":["K47R","S135R"],"nsp12":["D63N","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, F120L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T; nsp1: K47R, S135R; nsp12: D63N, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, Q52H, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, I1114T"}}},{"name":"XDN","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","C280T","T670G","C897A","C1762A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C11812A","C12789T","C12815T","C12880T","T13339C","C14408T","C14425T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28087T","A28271T","T28282C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*","A65V"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D","F319L"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*, A65V; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D, F319L; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K"}}},{"name":"XDS","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDS"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","G598A","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29409T","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","C29836T"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","T379I","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, T379I, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDT","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C1601T","C2790T","C3037T","G3431T","G4184A","T4654C","T5767C","T7633C","A7842G","C8293T","G8393A","A8633G","C9344T","A9424G","C9534T","C9661T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T11940C","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22227T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","A25045G","C25416T","T25496C","C25584T","C25658T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","G27014A","C27059T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","C28005T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29778A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["I35T","T89I","T223I"],"ORF8":["G8*","P38S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","H69-","V70-","V127F","G142D","Y144-","R158G","N211-","L212I","V213G","L216F","A222V","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D","L266F"],"nsp3":["T24I","V238L","G489S","N1708S","A1892T"],"nsp4":["I27V","L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp7":["V33A"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: I35T, T89I, T223I; ORF8: G8*, P38S; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D, L266F; nsp3: T24I, V238L, G489S, N1708S, A1892T; nsp4: I27V, L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp7: V33A; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, H69-, V70-, V127F, G142D, Y144-, R158G, N211-, L212I, V213G, L216F, A222V, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}}},{"name":"XDU","node_attrs":{"div":111,"Nextclade_pango":{"value":"XDU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.63761"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9475349114594978"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.388402462005615}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","C2790T","C3037T","C3177T","C3587T","C3944A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","C12115T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","C22674T","T22679C","C22686T","A22688G","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26078T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I","T229I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","S371F","S373P","S375F","T376A","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","P153L","H290Y","Q409K","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I, T229I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, P153L, H290Y, Q409K, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, S371F, S373P, S375F, T376A, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XDY","node_attrs":{"div":127,"Nextclade_pango":{"value":"XDY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","A4G","C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","G19669A","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","G22131C","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","C22858T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","R190T","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["G17R","T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: G17R, T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, R190T, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XDW","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15919"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","T1030C","A2127G","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14120T","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21301T","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22350T","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A263V","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P227L","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp16":["P215S"],"nsp2":["A31D","Y441C"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P227L, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp16: P215S; nsp2: A31D, Y441C; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A263V, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}}},{"name":"XDZ","node_attrs":{"div":114,"Nextclade_pango":{"value":"XDZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7086T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","C23557T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S","T1456I"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S, T1456I; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XE","node_attrs":{"div":62,"Nextclade_pango":{"value":"XE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.693899154663086}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C14599T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XEB","node_attrs":{"div":119,"Nextclade_pango":{"value":"XEB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEB"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEA","node_attrs":{"div":122,"Nextclade_pango":{"value":"XEA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.41162"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2268340125514634"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","T4804G","A6183G","A7842G","G7850T","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","C13255T","T13339C","A13712G","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R"],"nsp12":["K91R","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","D695E","K1155R","N1708S","A1711S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R; nsp12: K91R, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, D695E, K1155R, N1708S, A1711S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XED","node_attrs":{"div":124,"Nextclade_pango":{"value":"XED"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":17.361},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XED"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9430T","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","A13308G","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25350T","C25584T","C26060T","C26270T","G26529C","C26577G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L","P1263L"],"nsp1":["S135R","T170I"],"nsp10":["K95R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L; nsp1: S135R, T170I; nsp10: K95R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L, P1263L"}}},{"name":"XEG","node_attrs":{"div":119,"Nextclade_pango":{"value":"XEG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":950.694},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","A2443G","C2790T","C2939T","C3037T","C3876T","G4184A","C4234T","C4321T","G6536A","A6646G","T6747C","C7819G","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T10723C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A17637G","A18163G","A18492G","G19327T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22928G","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","C23191T","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29706T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","F456V","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V","A430S"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","P74S","A386V","G489S","G1273S","L1343S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V, A430S; nsp15: T112I; nsp2: A31D; nsp3: T24I, P74S, A386V, G489S, G1273S, L1343S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, F456V, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}}},{"name":"XEE","node_attrs":{"div":125,"Nextclade_pango":{"value":"XEE"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEE"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.013909816741943}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A6626G","C7113T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","G17334T","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","C22000A","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","H146Q","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","T1303A","T1465I","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, T1303A, T1465I, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, H146Q, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XF","node_attrs":{"div":57,"Nextclade_pango":{"value":"XF"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.623017311096191}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","T1390C","A2255G","C3037T","G4181T","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C29632T"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp2":["I484V"],"nsp3":["A488S","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp2: I484V; nsp3: A488S, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XEF","node_attrs":{"div":124,"Nextclade_pango":{"value":"XEF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.12538"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":34.028},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7268345560655398"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","G4255T","C4321T","C4683T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21653-","C21654-","T21655-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","G22111T","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","T22566C","G22577C","G22578A","G22599C","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S31-","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","Q183H","N211-","L212I","V213G","L216F","H245N","A264D","I332V","L335S","G339H","R346T","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","A655V","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, A655V, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S31-, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, Q183H, N211-, L212I, V213G, L216F, H245N, A264D, I332V, L335S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}}},{"name":"XH","node_attrs":{"div":65,"Nextclade_pango":{"value":"XH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.385257720947266}},"branch_attrs":{"mutations":{"nuc":["C241T","T902C","C904A","G1244A","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25624T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28435T","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["H78Y","T223I"],"ORF9b":["P10S","E27-","N28-","A29-","P51L"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["C33R","G147S"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: H78Y, T223I; ORF9b: P10S, E27-, N28-, A29-, P51L; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: C33R, G147S; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XG","node_attrs":{"div":69,"Nextclade_pango":{"value":"XG"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XG"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","T5386G","C5672T","G5924A","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","A19855G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["I79V","T112I"],"nsp3":["K38R","P985S","V1069I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: I79V, T112I; nsp3: K38R, P985S, V1069I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XJ","node_attrs":{"div":65,"Nextclade_pango":{"value":"XJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","G11287-","T11288-","C11289-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","C27945T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["Q18*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106F","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: Q18*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106F, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XK","node_attrs":{"div":59,"Nextclade_pango":{"value":"XK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-3.62446"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C5147T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A16064G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23403G","C23525T","T23599G","C23604A","A23767G","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L","Q875R"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","R810C","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L, Q875R; nsp14: I42V; nsp15: T112I; nsp3: K38R, R810C, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XL","node_attrs":{"div":68,"Nextclade_pango":{"value":"XL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C241T","C875T","A2832G","C3037T","C3241T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G14229A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["L24F"],"nsp3":["K38R","V1069I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: L24F; nsp3: K38R, V1069I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XM","node_attrs":{"div":60,"Nextclade_pango":{"value":"XM"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XM"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.202031135559082}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XP","node_attrs":{"div":59,"Nextclade_pango":{"value":"XP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.023200000000000068"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3616394203564539"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.596989154815674}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24190C","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","C26880A","A27259C","C27807T","A28254-","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3G","Q19E","A63T","L120I"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF6":["L61D"],"ORF8":["I121-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T, L120I; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF6: L61D; ORF8: I121-; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XN","node_attrs":{"div":67,"Nextclade_pango":{"value":"XN"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XN"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.3213419914245605}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","G10986A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["R5K","S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: R5K, S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XQ","node_attrs":{"div":66,"Nextclade_pango":{"value":"XQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.557600498199463}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A17615G","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C","K460R"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C, K460R; nsp14: I42V; nsp15: T112I; nsp3: K38R; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XS","node_attrs":{"div":61,"Nextclade_pango":{"value":"XS"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XS"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.812868118286133}},"branch_attrs":{"mutations":{"nuc":["G210T","C241T","C3037T","G4181T","C5365T","C6196T","C6402T","C7124T","C8986T","G9053T","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15240T","A18163G","C21595T","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","G22578A","G22599A","T22673C","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","A23040G","G23048A","A23055G","A23063T","T23075C","C23202A","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","C24130A","A24424T","T24469A","C24503T","C25000T","C25584T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["I19T","A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","G339D","R346K","S371L","S373P","S375F","K417N","N440K","G446S","S477N","T478K","E484A","Q493R","G496S","Q498R","N501Y","Y505H","T547K","D614G","H655Y","N679K","P681H","N764K","D796Y","N856K","Q954H","N969K","L981F"],"nsp12":["P323L"],"nsp14":["I42V"],"nsp3":["A488S","P1228L","P1469S"],"nsp4":["V167L","T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F; nsp12: P323L; nsp14: I42V; nsp3: A488S, P1228L, P1469S; nsp4: V167L, T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"I19T, A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F"}}},{"name":"XT","node_attrs":{"div":63,"Nextclade_pango":{"value":"XT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.9682207107543945}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C13994T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21786T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G75V","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["A185V","P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: A185V, P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G75V, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XR","node_attrs":{"div":69,"Nextclade_pango":{"value":"XR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","C2470T","A2832G","C3037T","C4893T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","G13295A","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","A25524G","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","C27131T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp10":["D91N"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","T725I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp10: D91N; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, T725I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XU","node_attrs":{"div":67,"Nextclade_pango":{"value":"XU"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XU"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.814977645874023}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","T5386G","G5924A","G6513-","T6514-","T6515-","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C16887T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","V1069I","S1265-","L1266I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, V1069I, S1265-, L1266I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XW","node_attrs":{"div":68,"Nextclade_pango":{"value":"XW"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XW"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C241T","C2470T","A2832G","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","C10507T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12756T","C12880T","C14408T","C15714T","G16020T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","G489S"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T24I"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, G489S; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T24I","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XV","node_attrs":{"div":62,"Nextclade_pango":{"value":"XV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.5818281173706055}},"branch_attrs":{"mutations":{"nuc":["C241T","A2832G","C3037T","C3583T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","T13195C","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: L105-, S106-, G107-, I189V","spike_mutations":"G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XY","node_attrs":{"div":68,"Nextclade_pango":{"value":"XY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","A1585G","C2470T","A2832G","C3037T","T5386G","G6513-","T6514-","T6515-","G8393A","C10029T","C10449A","T11049C","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A11537G","C12085T","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","A22351G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26058T","C26060T","C26270T","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp4":["T492I"],"nsp5":["P132H"],"nsp6":["V26A","L105-","S106-","G107-","I189V"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: K38R, S1265-, L1266I, A1892T; nsp4: T492I; nsp5: P132H; nsp6: V26A, L105-, S106-, G107-, I189V","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"XZ","node_attrs":{"div":64,"Nextclade_pango":{"value":"XZ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XZ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.045811176300049}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","C15714T","C17410T","A18163G","C19955T","A20055G","G20398A","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","C22792T","G22813T","T22882G","G22992A","C22995A","A23013C","A23040G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C26060T","C26270T","A26530G","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C"],"E":["T9I"],"M":["D3G","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","S477N","T478K","E484A","Q493R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I","E260K"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I; M: D3G, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I, E260K; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}}},{"name":"internal_XBK","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1627T","C2790T","C3037T","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","T12574C","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBK.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"XBK","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.670267581939697}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCH","node_attrs":{"div":105,"Nextclade_pango":{"value":"XCH"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","A1124G","C1973T","A2163C","C2790T","C3037T","G4184A","C4321T","C7564T","T8737C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12467T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16856G","T17124C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22624T","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23673T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","G25947C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27741T","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28657T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["Q185H","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","L455F","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","S704L","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","D207G","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["R107G","E453A"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["A126S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: Q185H, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, D207G, R392C; nsp14: I42V; nsp15: T112I; nsp2: R107G, E453A; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: A126S","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, L455F, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCH.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9220A","T9952C","C23280T","C26907T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}}},{"name":"XCH","node_attrs":{"div":105,"Nextclade_pango":{"value":"XCH"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCH"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCT","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCT"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C1684T","C1889T","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C7051T","C9344T","A9424G","C9534T","C9693T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","A16878T","C17410T","T17859C","A18163G","A18492G","A19886G","C19955T","A20055G","C20320T","A20741G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22115G","A22190G","T22200G","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893C","G22898A","T22917G","G22927T","T22928C","T22942G","G22992A","C22995A","A23013C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","T24073C","C24134A","A24424T","T24469A","T24991A","C25000T","C25416T","C25584T","G25606A","C25721T","T25959C","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758A"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["A72T","A110V","T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","N185D","I210V","V213G","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444T","G446S","L452R","L455F","F456L","N460K","S477N","T478K","E484A","F486S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","L858I","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["K89R","T112I","H234Y"],"nsp16":["Q28R"],"nsp2":["R362C","A510V"],"nsp3":["T24I","G489S","G1001S"],"nsp4":["L264F","T327I","A380V","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: A72T, A110V, T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: K89R, T112I, H234Y; nsp16: Q28R; nsp2: R362C, A510V; nsp3: T24I, G489S, G1001S; nsp4: L264F, T327I, A380V, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T35I","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, N185D, I210V, V213G, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, L455F, F456L, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, L858I, Q954H, N969K"}},"children":[{"name":"XCT.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"XCT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["G22331A","C23673T","G29734-","A29735-","A29758-","G29759-"],"S":["G257S","S704L"]},"labels":{"aa":"S: G257S, S704L","spike_mutations":"G257S, S704L"}}},{"name":"XCT","node_attrs":{"div":109,"Nextclade_pango":{"value":"XCT"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCT"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XDA","node_attrs":{"div":105,"Nextclade_pango":{"value":"XDA"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","T670G","A1269G","C2790T","C3037T","G4184A","C4321T","T8908C","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C11750T","C11956T","T12730A","C12880T","A13693G","C14408T","A14856G","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","G18703T","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","A22101T","A22106C","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995G","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","G23222A","A23403G","C23525T","T23599G","C23604A","C23664T","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28471T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-","S63F"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","E180V","K182Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478R","E484A","F486P","F490S","Q498R","N501Y","Y505H","E554K","D614G","H655Y","N679K","P681H","A701V","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["T85A","P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V","D222Y"],"nsp15":["T112I"],"nsp2":["D155G"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","L260F"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-, S63F; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: T85A, P323L, G671S; nsp13: S36P, R392C; nsp14: I42V, D222Y; nsp15: T112I; nsp2: D155G; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, L260F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, E180V, K182Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478R, E484A, F486P, F490S, Q498R, N501Y, Y505H, E554K, D614G, H655Y, N679K, P681H, A701V, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDA.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"XDA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17664C","C22088T","G27952A"],"ORF8":["C20Y"],"S":["L176F"]},"labels":{"aa":"ORF8: C20Y; S: L176F","spike_mutations":"L176F"}}},{"name":"XDA","node_attrs":{"div":105,"Nextclade_pango":{"value":"XDA"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDA"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XEC","node_attrs":{"div":127,"Nextclade_pango":{"value":"XEC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C21T","C241T","T670G","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18657T","C18894T","C19716T","C19955T","A20055G","C21618T","C21622T","G21624C","C21627A","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21738C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22928C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","C23039G","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","G24872T","C24990T","C25000T","C25006T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28291A","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","G28884C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204P","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P3H","P10S","E27-","N28-","A29-"],"S":["R21T","T22N","L24-","P25-","P26-","A27S","S50L","F59S","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","F456L","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q493E","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","V1104L","P1143L"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204P, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P3H, P10S, E27-, N28-, A29-; S: R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, T22N, L24-, P25-, P26-, A27S, S50L, F59S, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, V1104L, P1143L"}},"children":[{"name":"XEC.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"XEC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":29.34},"designation_date":{"value":"2024-08-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A424G","G2060A","C12809T","A22107G","C22414T"],"S":["K182R"],"nsp2":["A419T"],"nsp9":["L42F"]},"labels":{"aa":"S: K182R; nsp2: A419T; nsp9: L42F","spike_mutations":"K182R"}}},{"name":"XEC","node_attrs":{"div":127,"Nextclade_pango":{"value":"XEC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":34.028},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XEC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_XCF","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4006A","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","T17067C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22928C","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","T26012G","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["F207C","T223I"],"ORF8":["G8*"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","F456L","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: F207C, T223I; ORF8: G8*; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, F456L, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XCF","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000008","node_attrs":{"div":93,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}},"children":[{"name":"XCF.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"XCF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C22033A","C27881T","C29632T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"NODE_0000009","node_attrs":{"div":94,"Nextclade_pango":{"value":"XCF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C19263T"]}},"children":[{"name":"XCF.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XCF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18357G","G24348T"],"S":["S929I"]},"labels":{"aa":"S: S929I","spike_mutations":"S929I"}}},{"name":"XCF.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XCF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XCF.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G21795T","C22522T"],"S":["R78M"]},"labels":{"aa":"S: R78M","spike_mutations":"R78M"}}}]}]}]},{"name":"internal_XDP","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C774T","C897A","C2790T","C3037T","G3431T","T3565C","G4184A","C4321T","A6183G","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","T18453C","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["S135R","T170I"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: S135R, T170I; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDP","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000011","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDP"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.758353233337402}},"branch_attrs":{"mutations":{}},"children":[{"name":"XDP.1","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1427T","T1455C","A24838T"],"S":["E1092D"],"nsp2":["H208Y","L217P"]},"labels":{"aa":"S: E1092D; nsp2: H208Y, L217P","spike_mutations":"E1092D"}}},{"name":"XDP.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6850A","G22487C","T27810C"],"ORF7b":["F19L"],"S":["E309Q"]},"labels":{"aa":"ORF7b: F19L; S: E309Q","spike_mutations":"E309Q"}}},{"name":"XDP.3","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDP.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}}]}]},{"name":"internal_XDR","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDR"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2668T","C2790T","C3037T","G4184A","C4321T","C6896T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDR","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDR"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000013","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDR.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5005T","G6077T","A14031G","T21738C","G22599C","C26801T"],"S":["F59S","R346T"],"nsp3":["A1120S"]},"labels":{"aa":"S: F59S, R346T; nsp3: A1120S","spike_mutations":"F59S, R346T"}},"children":[{"name":"XDR.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDR.1.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6690T","C20906A","T22930A","G28167A"],"ORF8":["E92K"],"S":["F456L"],"nsp16":["A83D"],"nsp3":["A1324V"]},"labels":{"aa":"ORF8: E92K; S: F456L; nsp16: A83D; nsp3: A1324V","spike_mutations":"F456L"}}},{"name":"XDR.1.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDR.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3784T","G11527T","A19137T"],"nsp14":["L366F"],"nsp6":["L185F"]},"labels":{"aa":"nsp14: L366F; nsp6: L185F"}}}]}]},{"name":"internal_XBL","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G3446A","C3796T","C3927T","G4184A","C4321T","C4586T","C5183T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","A20379G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22317T","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A28271T","C28311T","C28312T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["P10F","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G252V","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","A243T","S403L","G489S","P822S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: P10F, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, A243T, S403L, G489S, P822S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBL","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000015","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBL"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBL.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1393G"]}}},{"name":"XBL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2461C","A12850G","G23465A"],"S":["V635I"]},"labels":{"aa":"S: V635I","spike_mutations":"V635I"}}},{"name":"NODE_0000016","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBL.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C11824T","G14400T"]}},"children":[{"name":"XBL.3.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBL.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","C17766T","A23738G","G29702A"],"S":["I726V"]},"labels":{"aa":"S: I726V","spike_mutations":"I726V"}}},{"name":"XBL.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBL.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDQ","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{"nuc":["C21T","C44T","C241T","T670G","C897A","C2790T","C3037T","G3431T","G4184A","C4321T","A6183G","C7420T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C19955T","A20055G","C21618T","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","G22992A","C22995A","T23005A","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","G27915T","A27980G","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","C28846T","G28881A","G28882A","G28883C","T29023C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","N460K","S477N","T478K","N481K","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A31D"],"nsp3":["T24I","V238L","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A31D; nsp3: T24I, V238L, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-; nsp9: T35I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XDQ","node_attrs":{"div":113,"Nextclade_pango":{"value":"XDQ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.081354141235352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000018","node_attrs":{"div":114,"Nextclade_pango":{"value":"XDQ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.493661403656006}},"branch_attrs":{"mutations":{"nuc":["T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T22846C","G23009-","T23010-","T23011-"],"S":["L24-","P25-","P26-","A27S","V483-"]},"labels":{"aa":"S: L24-, P25-, P26-, A27S, V483-","spike_mutations":"L24-, P25-, P26-, A27S, V483-"}},"children":[{"name":"XDQ.3","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDQ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.217390537261963}},"branch_attrs":{"mutations":{"nuc":["T2461G","G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"XDQ.2","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T8670G","A23021G"],"S":["N487D"],"nsp4":["F39C"]},"labels":{"aa":"S: N487D; nsp4: F39C","spike_mutations":"N487D"}}},{"name":"NODE_0000019","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDQ.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.296817302703857}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"XDQ.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.296817302703857}},"branch_attrs":{"mutations":{}}},{"name":"XDQ.1.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDQ.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}}]}]}]},{"name":"internal_XBJ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C1471T","C2445T","C2790T","C3037T","G3072A","G4184A","C4321T","T5406C","A6770G","C6786T","C8016T","C8208T","C8991T","C9344T","A9424G","C9534T","C9866T","C10029T","C10189T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12030G","C12880T","C14408T","C15714T","C17410T","C17678T","A18163G","C18252T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","T22020C","T22054G","T22200G","C22295A","G22332A","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","A22893G","A22910G","C22916A","T22942G","G22992A","C22995A","G23012A","A23013G","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25584T","C25896T","C26060T","C26270T","G26529A","C26577G","G26709A","C27012T","C27513T","C27807T","C27889T","A28271T","C28311T","A28330G","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3N","Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF6":["L61D"],"ORF9b":["P10S","D16G","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","M153T","N164K","V213G","H245N","G257D","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","K444R","N450D","L452M","N460K","S477N","T478K","E484R","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L"],"nsp13":["R392C","T481M"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["T547I"],"nsp3":["T24I","C118Y","G489S","I896T","M1351V","T1356I","A1766V","T1830I"],"nsp4":["A146V","L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp7":["Q63R"]},"labels":{"aa":"E: T9I; M: D3N, Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF6: L61D; ORF9b: P10S, D16G, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L; nsp13: R392C, T481M; nsp14: I42V; nsp15: T112I; nsp2: T547I; nsp3: T24I, C118Y, G489S, I896T, M1351V, T1356I, A1766V, T1830I; nsp4: A146V, L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp7: Q63R","spike_mutations":"L24-, P25-, P26-, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBJ","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000021","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBJ"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBJ.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9049C","C13423T"],"nsp4":["K165N"]},"labels":{"aa":"nsp4: K165N"}}},{"name":"XBJ.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C22006T","C25075T"]}}},{"name":"XBJ.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}},{"name":"internal_63f4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A16011G"]}},"children":[{"name":"XBJ.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A253G","C21682T","G23016A","T24349C","C25452T","C27741T","C27847T","G28857A"],"N":["R195K"],"ORF7b":["S31L"],"S":["G485D"]},"labels":{"aa":"N: R195K; ORF7b: S31L; S: G485D","spike_mutations":"G485D"}}},{"name":"XBJ.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBJ.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_XDD","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2334T","C2790T","C3037T","G4184A","C4321T","G5720A","C6541T","A7842G","C8293T","G8393A","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","A27507C","C27807T","G27915T","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","C29625T","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF10":["S23F"],"ORF3a":["T223I"],"ORF8":["G8*"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["A510V"],"nsp3":["T24I","G489S","G1001S","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF10: S23F; ORF3a: T223I; ORF8: G8*; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp2: A510V; nsp3: T24I, G489S, G1001S, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDD","node_attrs":{"div":115,"Nextclade_pango":{"value":"XDD"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000024","node_attrs":{"div":116,"Nextclade_pango":{"value":"XDD"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.604482650756836}},"branch_attrs":{"mutations":{"nuc":["C44T"]}},"children":[{"name":"XDD.3","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C10252T","G12268A","T15562C","T17574G","A19609G","T22928C","C23277T"],"S":["F456L","T572I"],"nsp14":["T524A"]},"labels":{"aa":"S: F456L, T572I; nsp14: T524A","spike_mutations":"F456L, T572I"}}},{"name":"XDD.2","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"NODE_0000025","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDD.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"XDD.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000026","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["A23312G"],"S":["I584V"]},"labels":{"aa":"S: I584V","spike_mutations":"I584V"}},"children":[{"name":"XDD.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"XDD.1.1.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDD.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDD.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_XDK","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{"nuc":["C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C5314T","A6183G","A7842G","C8293T","G8393A","C9142T","C9344T","A9424G","C9534T","C10029T","C10198T","G10447A","C10449A","G11042T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11727A","C11747T","C12789T","C12815T","C12880T","T13339C","C14408T","C15714T","T15756A","C17410T","A18163G","A18492G","C18894T","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","C23277T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","C28958A","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","Q229K","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","T572I","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L"],"nsp13":["R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S","K1155R","N1708S","A1892T"],"nsp4":["L264F","T327I","T492I"],"nsp5":["P132H"],"nsp6":["V24F","S106-","G107-","F108-","R252K"],"nsp9":["T35I"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, Q229K, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L; nsp13: R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S, K1155R, N1708S, A1892T; nsp4: L264F, T327I, T492I; nsp5: P132H; nsp6: V24F, S106-, G107-, F108-, R252K; nsp9: T35I","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, T572I, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDK","node_attrs":{"div":118,"Nextclade_pango":{"value":"XDK"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543809413909912}},"branch_attrs":{"mutations":{}}},{"name":"internal_d852fd4c","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XDK.2","node_attrs":{"div":125,"Nextclade_pango":{"value":"XDK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T4996A","C11173T","C22928T","A23598G","C27297T"],"S":["L456F","K679R"]},"labels":{"aa":"S: L456F, K679R","spike_mutations":"L456F, K679R"}}},{"name":"XDK.3","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C44T","C10456A"],"nsp5":["F134L"]},"labels":{"aa":"nsp5: F134L"}}},{"name":"XDK.5","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.635818004608154}},"branch_attrs":{"mutations":{"nuc":["C22388T"]}}},{"name":"internal_0964eaa1","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK.4"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C25626T"]}},"children":[{"name":"XDK.4","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"XDK.4.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDK.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.4.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2388T","C3510T","C18646T"],"nsp14":["P203S"],"nsp2":["T528I"],"nsp3":["A264V"]},"labels":{"aa":"nsp14: P203S; nsp2: T528I; nsp3: A264V"}}}]},{"name":"internal_C29762T","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDK"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C29762T"]}},"children":[{"name":"XDK.6","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1633G","G22272A","T22297C","C25162A","C25163A","G28371T"],"N":["G30-","-33V"],"ORF9b":["V30L"],"S":["R237K","Q1201K"]},"labels":{"aa":"N: G30-, -33V; ORF9b: V30L; S: R237K, Q1201K","spike_mutations":"R237K, Q1201K"}}},{"name":"internal_0d74e965","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G11596A","C18664T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"XDK.1.2","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.803860664367676}},"branch_attrs":{"mutations":{"nuc":["G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"NODE_0000032","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{"nuc":["C22928T"],"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}},"children":[{"name":"XDK.1.1","node_attrs":{"div":129,"Nextclade_pango":{"value":"XDK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0469899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1267T","C7528T","T18664C","A22107G","C22786A"],"S":["K182R","S408R"]},"labels":{"aa":"S: K182R, S408R","spike_mutations":"K182R, S408R"}}},{"name":"XDK.1","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDK.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.242274284362793}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_XBF","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{"nuc":["C241T","G625T","T670G","C1627T","C2790T","C3037T","T3339C","G4184A","C4321T","C6070T","C8692T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","A12444G","C12880T","C14408T","G15451A","C15714T","C17410T","A18163G","G18583A","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","G21987A","A22001G","T22016C","C22033A","A22190G","T22200G","G22331A","G22577C","G22578A","G22599C","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","T22942G","G22992A","C22995A","A23013C","T23018C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","G142D","K147E","W152R","F157L","I210V","V213G","G257S","G339H","R346T","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","N460K","S477N","T478K","E484A","F486P","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K120N","S135R"],"nsp12":["P323L","G671S"],"nsp13":["R392C"],"nsp14":["I42V","V182I"],"nsp15":["T112I"],"nsp3":["T24I","V207A","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp8":["N118S"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K120N, S135R; nsp12: P323L, G671S; nsp13: R392C; nsp14: I42V, V182I; nsp15: T112I; nsp3: T24I, V207A, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp8: N118S","spike_mutations":"L24-, P25-, P26-, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBF","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000034","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBF"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-3.6805543899536133}},"branch_attrs":{"mutations":{}},"children":[{"name":"XBF.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.10"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.294329643249512}},"branch_attrs":{"mutations":{"nuc":["G22021T","G29868T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBF.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G1085A","T3067C"],"nsp2":["V94I"]},"labels":{"aa":"nsp2: V94I"}}},{"name":"XBF.5","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.323378562927246}},"branch_attrs":{"mutations":{"nuc":["C2455T"]}}},{"name":"XBF.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.3351006507873535}},"branch_attrs":{"mutations":{"nuc":["T28078C"],"ORF8":["V62A"]},"labels":{"aa":"ORF8: V62A"}}},{"name":"XBF.6","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T12222C"],"nsp8":["V44A"]},"labels":{"aa":"nsp8: V44A"}}},{"name":"XBF.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.608235836029053}},"branch_attrs":{"mutations":{"nuc":["C1514T","C4252T"],"nsp2":["H237Y"]},"labels":{"aa":"nsp2: H237Y"}}},{"name":"XBF.9","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.9"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4586T","A16474G","T29035G"],"nsp13":["S80G"]},"labels":{"aa":"nsp13: S80G"}}},{"name":"NODE_0000035","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}},"children":[{"name":"XBF.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.710116863250732}},"branch_attrs":{"mutations":{}}},{"name":"XBF.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3728T","C23423T","A23989G"],"S":["P621S"],"nsp3":["G337C"]},"labels":{"aa":"S: P621S; nsp3: G337C","spike_mutations":"P621S"}}}]},{"name":"NODE_0000036","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.7"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{"nuc":["A1C","T625G","C29409T"],"N":["T379I"],"nsp1":["N120K"]},"labels":{"aa":"N: T379I; nsp1: N120K"}},"children":[{"name":"XBF.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.005673408508301}},"branch_attrs":{"mutations":{}}},{"name":"XBF.7.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBF.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.7.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C19099G","C22530T","T27546C","G29527A"],"S":["T323I"],"nsp14":["Q354E"]},"labels":{"aa":"S: T323I; nsp14: Q354E","spike_mutations":"T323I"}}}]},{"name":"NODE_0000037","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.8"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9931C","C12970T"]}},"children":[{"name":"XBF.8","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"XBF.8.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBF.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBF.8.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T3442C","C13255T","C22000T","C23423T","T25039C"],"S":["P621S"],"nsp1":["K141-","S142-","F143-"]},"labels":{"aa":"S: P621S; nsp1: K141-, S142-, F143-","spike_mutations":"P621S"}}}]}]}]},{"name":"internal_XAY","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","G4184A","C4321T","C4456T","C5869T","C7124T","C8595T","C8986T","G9053T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G12163A","C12747T","C12880T","C14408T","C15026T","G15451A","C16466T","C19220T","C21614T","C21618G","A21623G","C21846T","G21987A","G22017T","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","T22118C","T22200G","G22578A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22899A","C22916A","T22917G","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23423T","C23525T","T23599G","C23604A","C23679T","C23854A","G23948T","A24424T","T24469A","C24912T","C25413T","C25469T","C26681T","T26767C","G26959A","C27575G","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-","G29779T"],"M":["I82T","R146H"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["S26L"],"ORF6":["L61D"],"ORF7a":["T61S"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L18F","I19R","R21G","T95I","G142D","W152L","E156-","F157-","R158G","F186L","V213G","G339D","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446D","L452R","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","P621S","H655Y","N679K","P681H","A706V","N764K","D796Y","Q954H","N969K","T1117I"],"nsp1":["S135R"],"nsp12":["P323L","A529V","G671S"],"nsp13":["P77L"],"nsp14":["A394V"],"nsp3":["T24I","G489S","P1469S"],"nsp4":["T14I","V167L","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["T21I"]},"labels":{"aa":"M: I82T, R146H; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: S26L; ORF6: L61D; ORF7a: T61S; ORF9b: P10S, E27-, N28-, A29-; S: L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I; nsp1: S135R; nsp12: P323L, A529V, G671S; nsp13: P77L; nsp14: A394V; nsp3: T24I, G489S, P1469S; nsp4: T14I, V167L, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: T21I","spike_mutations":"L18F, I19R, R21G, T95I, G142D, W152L, E156-, F157-, R158G, F186L, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446D, L452R, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, P621S, H655Y, N679K, P681H, A706V, N764K, D796Y, Q954H, N969K, T1117I"}},"children":[{"name":"XAY","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000039","node_attrs":{"div":77,"Nextclade_pango":{"value":"XAY"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}},"children":[{"name":"XAY.3","node_attrs":{"div":79,"Nextclade_pango":{"value":"XAY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["C1288T","G19072T"],"nsp14":["D345Y"]},"labels":{"aa":"nsp14: D345Y"}}},{"name":"NODE_0000040","node_attrs":{"div":80,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.995934963226318}},"branch_attrs":{"mutations":{"nuc":["A2410G","A11559G","C15081T"],"nsp6":["Y196C"]},"labels":{"aa":"nsp6: Y196C"}},"children":[{"name":"XAY.2","node_attrs":{"div":80,"Nextclade_pango":{"value":"XAY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.995934963226318}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000041","node_attrs":{"div":81,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.154902458190918}},"branch_attrs":{"mutations":{"nuc":["T9642C"],"nsp4":["I363T"]},"labels":{"aa":"nsp4: I363T"}},"children":[{"name":"XAY.2.3","node_attrs":{"div":82,"Nextclade_pango":{"value":"XAY.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000204563140869}},"branch_attrs":{"mutations":{"nuc":["C657T"],"nsp1":["A131V"]},"labels":{"aa":"nsp1: A131V"}}},{"name":"NODE_0000042","node_attrs":{"div":82,"Nextclade_pango":{"value":"XAY.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.154902458190918}},"branch_attrs":{"mutations":{"nuc":["T24721C"]}},"children":[{"name":"XAY.2.1","node_attrs":{"div":83,"Nextclade_pango":{"value":"XAY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796263694763184}},"branch_attrs":{"mutations":{"nuc":["A28343G"],"N":["T24A"]},"labels":{"aa":"N: T24A"}}},{"name":"XAY.2.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.2.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.699412822723389}},"branch_attrs":{"mutations":{"nuc":["C635T","A1605G"],"nsp1":["R124C"],"nsp2":["N267S"]},"labels":{"aa":"nsp1: R124C; nsp2: N267S"}}}]}]}]},{"name":"NODE_0000043","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.521972179412842}},"branch_attrs":{"mutations":{"nuc":["A385G","G407A","A9419G","C10301A","G20679T","A22320G","C28720T"],"S":["D253G"],"nsp1":["D48N"],"nsp4":["I289V"],"nsp5":["Q83K"]},"labels":{"aa":"S: D253G; nsp1: D48N; nsp4: I289V; nsp5: Q83K","spike_mutations":"D253G"}},"children":[{"name":"XAY.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"XAY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.521972179412842}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6144499999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C11202T","C28432T"],"ORF9b":["S50L"],"nsp6":["T77I"]},"labels":{"aa":"ORF9b: S50L; nsp6: T77I"}}},{"name":"NODE_0000044","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["G6589C","G22599C"],"S":["R346T"],"nsp3":["K1290N"]},"labels":{"aa":"S: R346T; nsp3: K1290N","spike_mutations":"R346T"}},"children":[{"name":"XAY.1.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"XAY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{}}},{"name":"XAY.1.1.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.397429943084717}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C14838T","G27575C"],"ORF7a":["S61T"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"ORF7a: S61T; nsp1: G82-, H83-, V84-, M85V"}}},{"name":"NODE_0000045","node_attrs":{"div":87,"Nextclade_pango":{"value":"XAY.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C14599T"]}},"children":[{"name":"XAY.1.1.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XAY.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.0969953536987305}},"branch_attrs":{"mutations":{"nuc":["C6040T","C8290T","T15153C"]}}},{"name":"NODE_0000046","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{"nuc":["G25019T"],"S":["D1153Y"]},"labels":{"aa":"S: D1153Y","spike_mutations":"D1153Y"}},"children":[{"name":"GL.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"GL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.778546333312988}},"branch_attrs":{"mutations":{"nuc":["C5183T","C8140T"],"nsp3":["P822S"]},"labels":{"aa":"nsp3: P822S"}}},{"name":"XAY.1.1.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"XAY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.16967248916626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000047","node_attrs":{"div":89,"Nextclade_pango":{"value":"XAY.1.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.697271823883057}},"branch_attrs":{"mutations":{"nuc":["C25585T"],"ORF3a":["L65F"]},"labels":{"aa":"ORF3a: L65F"}},"children":[{"name":"GL.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"GL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6888599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752889267417711"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.495382308959961}},"branch_attrs":{"mutations":{"nuc":["C19441T","T21992-","A21993-","T21994-","G22820A"],"S":["Y144-","D420N"]},"labels":{"aa":"S: Y144-, D420N","spike_mutations":"Y144-, D420N"}}},{"name":"GL.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"GL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.72587"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XAY.1.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-7.959722995758057}},"branch_attrs":{"mutations":{"nuc":["C44T","T2432C","C3511T","T4165C","A25431G","G28321T"],"ORF9b":["R13L"],"nsp2":["S543P"]},"labels":{"aa":"ORF9b: R13L; nsp2: S543P"}}}]}]}]}]}]}]}]},{"name":"internal_XDV","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDV"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C241T","A405G","C541T","T670G","C1170T","C2790T","C3037T","G4184A","C4321T","C6501A","C7113T","C9344T","A9424G","C9534T","C9866T","C10029T","A10042G","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12473T","C12880T","C12924T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","C21622T","G21624C","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","G21987A","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","T22200G","C22208T","C22295A","C22353A","A22556G","G22577C","G22578A","A22629C","C22674T","T22679C","C22686T","A22688G","G22770A","G22775A","A22786C","G22813T","T22882G","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22926C","T22942A","G22992A","C22995A","T23005A","G23009-","T23010-","T23011-","G23012A","T23018C","T23019C","A23055G","A23063T","T23075C","G23222A","C23271T","A23403G","C23423T","C23525T","T23599G","C23604G","C23854A","G23948T","C24378T","A24424T","T24469A","C24990T","C25000T","C25207T","C25584T","C26060T","C26270T","G26529C","C26577G","A26610G","C26681T","G26709A","C26833T","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","T27810C","A28271T","T28297C","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"E":["T9I"],"M":["D3H","Q19E","T30A","A63T","A104V"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF7b":["F19L"],"ORF9b":["I5T","P10S","E27-","N28-","A29-"],"S":["R21T","L24-","P25-","P26-","A27S","S50L","H69-","V70-","V127F","G142D","Y144-","F157S","R158G","N211-","L212I","V213G","L216F","H245N","A264D","I332V","G339H","K356T","S371F","S373P","S375F","T376A","R403K","D405N","R408S","K417N","N440K","V445H","G446S","N450D","L452W","L455S","N460K","S477N","T478K","N481K","V483-","E484K","F486P","Q498R","N501Y","Y505H","E554K","A570V","D614G","P621S","H655Y","N679K","P681R","N764K","D796Y","S939F","Q954H","N969K","P1143L"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp2":["S122F"],"nsp3":["T24I","G489S","P1261Q","T1465I"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"],"nsp9":["P80L"]},"labels":{"aa":"E: T9I; M: D3H, Q19E, T30A, A63T, A104V; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF7b: F19L; ORF9b: I5T, P10S, E27-, N28-, A29-; S: R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp2: S122F; nsp3: T24I, G489S, P1261Q, T1465I; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-; nsp9: P80L","spike_mutations":"R21T, L24-, P25-, P26-, A27S, S50L, H69-, V70-, V127F, G142D, Y144-, F157S, R158G, N211-, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, N460K, S477N, T478K, N481K, V483-, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, D796Y, S939F, Q954H, N969K, P1143L"}},"children":[{"name":"XDV","node_attrs":{"div":117,"Nextclade_pango":{"value":"XDV"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XDV"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000049","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDV.1"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C11572T","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","clade":"24D","spike_mutations":"F456L"}},"children":[{"name":"XDV.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"XDV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.1","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4579A","T9208G","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"XDV.1.10","node_attrs":{"div":125,"Nextclade_pango":{"value":"XDV.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.10"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9365T","C12789T","G22104T","C25782T","A28870T","G29254A"],"S":["G181V"],"nsp9":["T35I"]},"labels":{"aa":"S: G181V; nsp9: T35I","spike_mutations":"G181V"}}},{"name":"XDV.1.11","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.11"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T4057C"]}}},{"name":"XDV.1.3","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.3"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"XDV.1.5","node_attrs":{"div":124,"Nextclade_pango":{"value":"XDV.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14808999999999992"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5359962252743784"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.5"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8299T","C16323T","G22112A","A22995T","C28432T"],"ORF9b":["S50L"],"S":["G184S","K478I"]},"labels":{"aa":"ORF9b: S50L; S: G184S, K478I","spike_mutations":"G184S, K478I"}}},{"name":"XDV.1.4","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.4"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T24903C"],"S":["I1114T"]},"labels":{"aa":"S: I1114T","spike_mutations":"I1114T"}}},{"name":"XDV.1.6","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDV.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.6"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C147T","G3892T","C4551T","G5612A","C9985T","C21871T","C26882T"],"nsp3":["E391D","T611I","V965I"]},"labels":{"aa":"nsp3: E391D, T611I, V965I"}}},{"name":"XDV.1.8","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.8"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2551C","T9892G"]}}},{"name":"NODE_0000050","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.2"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9611T","G22599C","T29148C"],"N":["I292T"],"S":["R346T"],"nsp4":["L353F"]},"labels":{"aa":"N: I292T; S: R346T; nsp4: L353F","spike_mutations":"R346T"}},"children":[{"name":"XDV.1.2","node_attrs":{"div":122,"Nextclade_pango":{"value":"XDV.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.2.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"XDV.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26874999999999993"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":6.25},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.8051577060608006"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.2.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1093T","C7948T","C11750T","T21775G","A22947G"],"S":["K462R"],"nsp6":["L260F"]},"labels":{"aa":"S: K462R; nsp6: L260F","spike_mutations":"K462R"}}}]},{"name":"NODE_0000051","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.7"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["C8950T","G9203A"],"nsp4":["D217N"]},"labels":{"aa":"nsp4: D217N"}},"children":[{"name":"XDV.1.7.1","node_attrs":{"div":126,"Nextclade_pango":{"value":"XDV.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"2-3 weeks"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2306T","C5173T","C8683T","C21627A","G21746T"],"S":["T22N","V62F"],"nsp2":["L501F"]},"labels":{"aa":"S: T22N, V62F; nsp2: L501F","spike_mutations":"T22N, V62F"}}},{"name":"XDV.1.7","node_attrs":{"div":121,"Nextclade_pango":{"value":"XDV.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.7"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000052","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.9"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["C6855T"],"nsp3":["T1379I"]},"labels":{"aa":"nsp3: T1379I"}},"children":[{"name":"XDV.1.9","node_attrs":{"div":120,"Nextclade_pango":{"value":"XDV.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{}}},{"name":"XDV.1.9.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"XDV.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20783000000000001"},"designation_recency":{"value":"2-3 weeks"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5422010449483097"},"clade_display":{"value":"24D (XDV.1)"},"partiallyAliased":{"value":"XDV.1.9.1"},"clade_nextstrain":{"value":"24D"},"clade_membership":{"value":"24D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G4255A","G4300T","A21651-","T21652-","T21653-","C21654-","T21655-","T21656-","G22865T"],"S":["N30-","S31-","F32I","A435S"]},"labels":{"aa":"S: N30-, S31-, F32I, A435S","spike_mutations":"N30-, S31-, F32I, A435S"}}}]}]}]},{"name":"internal_XBC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C241T","T670G","C2790T","C3037T","C4893T","C5184T","A5584G","C6196T","G6576T","G7091A","C9073T","C9891T","T11418C","C11514T","C13019T","C14408T","T15030C","C15237T","G15451A","C16466T","C16616T","C21618T","C21635T","G21987A","T21992-","A21993-","T21994-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22188T","T22197C","G22205C","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22329T","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22898A","G22992A","C22995A","A23013C","T23018C","T23019C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","A23670T","C23854A","G23948T","A24424T","T24469A","C25000T","C25854T","T26767C","T26819C","T27718C","C27752T","G27890T","A27898C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28271-","A28461G","G28881T","G29402T","G29742T"],"M":["I82T"],"N":["D63G","R203M","D377Y"],"ORF6":["L61D"],"ORF7a":["F109L","T120I"],"ORF8":["K2T","D119-","F120-"],"ORF9b":["T60A"],"S":["P25S","G142D","Y144-","E156-","F157-","R158G","P209L","L212S","D215H","A222V","L242-","A243-","S256L","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","G446S","S477N","T478K","E484A","F486P","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N703I","N764K","D796Y","Q954H","N969K"],"nsp1":["S135R"],"nsp12":["P323L","G671S"],"nsp13":["P77L","T127I"],"nsp3":["T24I","T725I","P822L","S1286I","V1458I"],"nsp4":["A446V"],"nsp6":["V149A","T181I"]},"labels":{"aa":"M: I82T; N: D63G, R203M, D377Y; ORF6: L61D; ORF7a: F109L, T120I; ORF8: K2T, D119-, F120-; ORF9b: T60A; S: P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K; nsp1: S135R; nsp12: P323L, G671S; nsp13: P77L, T127I; nsp3: T24I, T725I, P822L, S1286I, V1458I; nsp4: A446V; nsp6: V149A, T181I","spike_mutations":"P25S, G142D, Y144-, E156-, F157-, R158G, P209L, L212S, D215H, A222V, L242-, A243-, S256L, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, S477N, T478K, E484A, F486P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N703I, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBC","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6871599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000054","node_attrs":{"div":67,"Nextclade_pango":{"value":"XBC"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T27792-","T27793-"],"ORF7b":["F13-"]},"labels":{"aa":"ORF7b: F13-"}},"children":[{"name":"NODE_0000055","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8858A","T14034C","A21852G","A29188T"],"S":["K97R"],"nsp4":["V102I"]},"labels":{"aa":"S: K97R; nsp4: V102I","spike_mutations":"K97R"}},"children":[{"name":"XBC.2","node_attrs":{"div":72,"Nextclade_pango":{"value":"XBC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6871599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.2616082621302063"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1758T","G27993-"],"ORF8":["D34-"],"nsp2":["A318V"]},"labels":{"aa":"ORF8: D34-; nsp2: A318V"}}},{"name":"XBC.2.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.58838"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.44507236664312827"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C222T","C1627T","G4184A","C9541T","A22893C","G27936A"],"ORF8":["A15T"],"S":["K444T"],"nsp3":["G489S"]},"labels":{"aa":"ORF8: A15T; S: K444T; nsp3: G489S","spike_mutations":"K444T"}}}]},{"name":"NODE_0000056","node_attrs":{"div":69,"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1437T","C22916A"],"S":["L452M"],"nsp2":["S211F"]},"labels":{"aa":"S: L452M; nsp2: S211F","spike_mutations":"L452M"}},"children":[{"name":"XBC.1","node_attrs":{"div":69,"Nextclade_pango":{"value":"XBC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7b:14-44,ORF8:35-122"},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.frameShifts":{"value":"ORF8:35-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G27993-"],"ORF8":["D34-"]},"labels":{"aa":"ORF8: D34-"}}},{"name":"NODE_0000057","node_attrs":{"div":70,"Nextclade_pango":{"value":"XBC.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"nsp4":["T492I"]},"labels":{"aa":"nsp4: T492I"}},"children":[{"name":"XBC.1.4","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","C12119T","T12480C","A15847C","G22112A","C28807A"],"S":["G184S"],"nsp1":["G82-","H83-","V84-"],"nsp12":["T803P"],"nsp8":["P10S","V130A"]},"labels":{"aa":"S: G184S; nsp1: G82-, H83-, V84-; nsp12: T803P; nsp8: P10S, V130A","spike_mutations":"G184S"}}},{"name":"XBC.1.5","node_attrs":{"div":74,"Nextclade_pango":{"value":"XBC.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C44T","C2388T","C6255T","A10042C"],"nsp2":["T528I"],"nsp3":["A1179V"]},"labels":{"aa":"nsp2: T528I; nsp3: A1179V"}}},{"name":"NODE_0000058","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.2"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11269C"]}},"children":[{"name":"XBC.1.2.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G188A","C5314A","C10741T","C13862T","C20178T","T22846C"],"nsp12":["T141I"]},"labels":{"aa":"nsp12: T141I"}}},{"name":"XBC.1.2","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["-27792T","-27793T"],"ORF7b":["-13F"]},"labels":{"aa":"ORF7b: -13F"}}}]},{"name":"NODE_0000059","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{"nuc":["G248T","A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","T1564C","T4885C","G8353A","T11121C","C27002T","G28233C"],"ORF8":["V114L"],"nsp1":["K141-","S142-","F143-"],"nsp6":["I50T"]},"labels":{"aa":"ORF8: V114L; nsp1: K141-, S142-, F143-; nsp6: I50T"}},"children":[{"name":"XBC.1.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.8057050704956055}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000060","node_attrs":{"div":78,"Nextclade_pango":{"value":"XBC.1.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["G8851T"]}},"children":[{"name":"XBC.1.1.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"XBC.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11213999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48837241784414276"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22988A"],"S":["G476S"]},"labels":{"aa":"S: G476S","spike_mutations":"G476S"}}},{"name":"XBC.1.1.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C635T","C1684T","T13019C","C26177T","C27494T","C27849T"],"ORF3a":["P262L"],"ORF7a":["P34L"],"nsp1":["R124C"]},"labels":{"aa":"ORF3a: P262L; ORF7a: P34L; nsp1: R124C"}}}]}]},{"name":"NODE_0000061","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.7"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A17207G","A22893C","A22995G","C23188T","C27434T"],"ORF7a":["T14I"],"S":["K444T","K478R"],"nsp13":["Y324C"]},"labels":{"aa":"ORF7a: T14I; S: K444T, K478R; nsp13: Y324C","spike_mutations":"K444T, K478R"}},"children":[{"name":"XBC.1.7","node_attrs":{"div":75,"Nextclade_pango":{"value":"XBC.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.7.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4586T","A22116G"],"S":["N185S"]},"labels":{"aa":"S: N185S","spike_mutations":"N185S"}}},{"name":"XBC.1.7.2","node_attrs":{"div":79,"Nextclade_pango":{"value":"XBC.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5473299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6307633281941917"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.7.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","G3281A","C22458T","G27798T"],"S":["T299I"],"nsp3":["V188I"]},"labels":{"aa":"S: T299I; nsp3: V188I","spike_mutations":"T299I"}}}]},{"name":"NODE_0000062","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"XBC.1.3","node_attrs":{"div":71,"Nextclade_pango":{"value":"XBC.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000063","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C1628A","C6145T","T6447C","C12786T","G15743A","A25910G","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-"],"ORF3a":["D173G"],"ORF7a":["C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp12":["S768N"],"nsp2":["Q275K"],"nsp3":["V1243A"],"nsp9":["T34I"]},"labels":{"aa":"ORF3a: D173G; ORF7a: C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-; nsp1: G82-, H83-, V84-, M85-, V86-; nsp12: S768N; nsp2: Q275K; nsp3: V1243A; nsp9: T34I"}},"children":[{"name":"XBC.1.3.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"XBC.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000064","node_attrs":{"div":78,"Nextclade_pango":{"value":"XBC.1.3.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A3063T","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-"],"nsp3":["E115V"]},"labels":{"aa":"nsp3: E115V"}},"children":[{"name":"KD.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"KD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C44T","C6286T","A11246T","G12067T","T22963C","C25844T"],"ORF3a":["T151I"],"nsp6":["M92L"],"nsp7":["M75I"]},"labels":{"aa":"ORF3a: T151I; nsp6: M92L; nsp7: M75I"}}},{"name":"KD.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"KD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7857899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"KD.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"KD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":21},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:66-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C10519T","C19524T"]}}},{"name":"KD.4","node_attrs":{"div":82,"Nextclade_pango":{"value":"KD.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.79272"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:64-122,ORF7b:14-44"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.3.1.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1446G","C2453T","C3159T","C16092T","-27582T","-27583G","-27584C","-27585T","-27586T"],"nsp2":["K214R","L550F"],"nsp3":["T147I"]},"labels":{"aa":"nsp2: K214R, L550F; nsp3: T147I"}}}]}]}]},{"name":"NODE_0000065","node_attrs":{"div":83,"Nextclade_pango":{"value":"XBC.1.6"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["C2334T","G3606T","C8240T","C8782T","C12733T","C15180T","T16986C","A17233G","A22600T","T22917G","T24529C","C25603T","C28801T"],"S":["R346S","M452R"],"nsp13":["I333V"],"nsp2":["A510V"],"nsp3":["C296F","H1841Y"]},"labels":{"aa":"S: R346S, M452R; nsp13: I333V; nsp2: A510V; nsp3: C296F, H1841Y","spike_mutations":"R346S, M452R"}},"children":[{"name":"XBC.1.6","node_attrs":{"div":83,"Nextclade_pango":{"value":"XBC.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{}}},{"name":"XBC.1.6.2","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["G2744A"],"nsp3":["D9N"]},"labels":{"aa":"nsp3: D9N"}}},{"name":"XBC.1.6.4","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.4"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T3214C","G3614A","T20286C"],"nsp3":["V299I"]},"labels":{"aa":"nsp3: V299I"}}},{"name":"XBC.1.6.5","node_attrs":{"div":87,"Nextclade_pango":{"value":"XBC.1.6.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.5"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1594T","A11830G","C15601T","C27661T"],"ORF7a":["Q90*"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp12":["R721C"]},"labels":{"aa":"ORF7a: Q90*; nsp1: G82-, H83-, V84-, M85V; nsp12: R721C"}}},{"name":"NODE_0000066","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C28000T"],"ORF8":["P36L"]},"labels":{"aa":"ORF8: P36L"}},"children":[{"name":"GT.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"GT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","A21875G","C28333T"],"ORF9b":["P17L"],"S":["I105V"]},"labels":{"aa":"ORF9b: P17L; S: I105V","spike_mutations":"I105V"}}},{"name":"XBC.1.6.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"XBC.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000067","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.6"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T8707C","C10156T","C26735T"]}},"children":[{"name":"JT.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"JT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47217000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7550301657183831"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21T","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","T22896C"],"S":["V445A"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"S: V445A; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"V445A"}}},{"name":"XBC.1.6.6","node_attrs":{"div":86,"Nextclade_pango":{"value":"XBC.1.6.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.6"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000068","node_attrs":{"div":85,"Nextclade_pango":{"value":"XBC.1.6.3"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["C13297T","C28791T"],"N":["A173V"]},"labels":{"aa":"N: A173V"}},"children":[{"name":"XBC.1.6.3","node_attrs":{"div":85,"Nextclade_pango":{"value":"XBC.1.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000069","node_attrs":{"div":88,"Nextclade_pango":{"value":"HW.1"},"clade_who":{"value":"recombinant"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["C44T","C5055T","C6633T"],"nsp3":["T779I","A1305V"]},"labels":{"aa":"nsp3: T779I, A1305V"}},"children":[{"name":"HW.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"HW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.63844"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420325830319254"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T16242A","C22120T","A22940C"],"S":["N460H"]},"labels":{"aa":"S: N460H","spike_mutations":"N460H"}}},{"name":"HW.1.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.2"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G15957A"]}}},{"name":"HW.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"HW.1.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"HW.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6392699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"recombinant"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"recombinant"},"partiallyAliased":{"value":"XBC.1.6.3.1.3"},"clade_nextstrain":{"value":"recombinant"},"clade_membership":{"value":"recombinant"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C29445T"],"N":["T391I"]},"labels":{"aa":"N: T391I"}}}]}]}]}]}]}]}]},{"name":"internal_XBB","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{"nuc":["A1G","C44T","C241T","A405G","T670G","C2790T","C3037T","G4184A","C4321T","C9344T","A9424G","C9534T","C9866T","C10029T","C10198T","G10447A","C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12880T","C14408T","G15451A","C15714T","C15738T","T15939C","T16342C","C17410T","T17859C","A18163G","A19326G","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21810C","G21987A","T21992-","A21993-","T21994-","C22000A","C22109G","T22200A","G22577C","G22578A","G22599C","C22664A","C22674T","T22679C","C22686T","A22688G","G22775A","A22786C","G22813T","T22882G","G22895C","T22896C","G22898A","T22942G","G22992A","C22995A","A23013C","T23019C","T23031C","A23055G","A23063T","T23075C","A23403G","C23525T","T23599G","C23604A","C23854A","G23948T","A24424T","T24469A","C25000T","C25416T","C25584T","C26060T","C26270T","A26275G","C26577G","G26709A","C26858T","A27259C","G27382C","A27383T","T27384C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-","G28881A","G28882A","G28883C","A29510C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"E":["T9I","T11A"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-","R203K","G204R","S413R"],"ORF3a":["T223I"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["L24-","P25-","P26-","A27S","V83A","G142D","Y144-","H146Q","Q183E","V213E","G339H","R346T","L368I","S371F","S373P","S375F","T376A","D405N","R408S","K417N","N440K","V445P","G446S","N460K","S477N","T478K","E484A","F486S","F490S","Q498R","N501Y","Y505H","D614G","H655Y","N679K","P681H","N764K","D796Y","Q954H","N969K"],"nsp1":["K47R","S135R"],"nsp12":["P323L","G671S"],"nsp13":["S36P","R392C"],"nsp14":["I42V"],"nsp15":["T112I"],"nsp3":["T24I","G489S"],"nsp4":["L264F","T327I","L438F","T492I"],"nsp5":["P132H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"E: T9I, T11A; M: Q19E, A63T; N: P13L, E31-, R32-, S33-, R203K, G204R, S413R; ORF3a: T223I; ORF9b: P10S, E27-, N28-, A29-; S: L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K; nsp1: K47R, S135R; nsp12: P323L, G671S; nsp13: S36P, R392C; nsp14: I42V; nsp15: T112I; nsp3: T24I, G489S; nsp4: L264F, T327I, L438F, T492I; nsp5: P132H; nsp6: S106-, G107-, F108-","clade":"22F","spike_mutations":"L24-, P25-, P26-, A27S, V83A, G142D, Y144-, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"XBB","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000071","node_attrs":{"div":88,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.3508477210998535}},"branch_attrs":{"mutations":{"nuc":["G29759-"]}},"children":[{"name":"NODE_0000072","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.215944766998291}},"branch_attrs":{"mutations":{"nuc":["G510A"],"nsp1":["G82D"]},"labels":{"aa":"nsp1: G82D"}},"children":[{"name":"XBB.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T44C","T5851C","G8861A","G11516T","C17502T","C28419T"],"N":["T49I"],"nsp4":["V103M"],"nsp6":["V182F"]},"labels":{"aa":"N: T49I; nsp4: V103M; nsp6: V182F"}}},{"name":"NODE_0000073","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"XBB.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3064099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.655797004699707}},"branch_attrs":{"mutations":{}}},{"name":"XBB.4.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26627999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0810114368008295"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3784T","A3946G","T5218A","C6628T","C21575T","C22971A"],"S":["L5F","T470N"],"nsp3":["N833K"]},"labels":{"aa":"S: L5F, T470N; nsp3: N833K","spike_mutations":"L5F, T470N"}}}]},{"name":"NODE_0000074","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4179558753967285}},"branch_attrs":{"mutations":{"nuc":["G5518A"]}},"children":[{"name":"XBB.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"XBB.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C106T","A6193G","T20040C","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000075","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["C14178T"]}},"children":[{"name":"XBB.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.619609355926514}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.6.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C14362T","C22792A","T23018C","C25539T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}}]},{"name":"NODE_0000076","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["T14574C"]}},"children":[{"name":"XBB.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.116075038909912}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"NODE_0000077","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.8.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2167T","A8437G","A10323G","C25665T"],"nsp2":["K454N"],"nsp5":["K90R"]},"labels":{"aa":"nsp2: K454N; nsp5: K90R"}}},{"name":"XBB.8.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.8.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.436409950256348}},"branch_attrs":{"mutations":{"nuc":["T1507G","C7851T"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}}}]}]},{"name":"NODE_0000078","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["A19459G"],"nsp14":["I474V"]},"labels":{"aa":"nsp14: I474V"}},"children":[{"name":"XBB.3","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.480696678161621}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.3.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8146T","T22092C","C28054T"],"ORF8":["S54L"],"S":["M177T"]},"labels":{"aa":"ORF8: S54L; S: M177T","spike_mutations":"M177T"}}},{"name":"XBB.3.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.83066463470459}},"branch_attrs":{"mutations":{"nuc":["C3961T","A24532C"],"S":["E990D"]},"labels":{"aa":"S: E990D","spike_mutations":"E990D"}}},{"name":"XBB.3.5","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T44C","G219T","C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}}},{"name":"NODE_0000079","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T1993C"]}},"children":[{"name":"XBB.3.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}},{"name":"XBB.3.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.3.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C601T","G15025A","G24926T"],"S":["V1122L"],"nsp12":["A529T"]},"labels":{"aa":"S: V1122L; nsp12: A529T","spike_mutations":"V1122L"}}}]}]}]},{"name":"internal_XBB2","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.122056484222412}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}},"children":[{"name":"XBB.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.122056484222412}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.12","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C4090T","G21255T","G23401C","T24194C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.165473937988281}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.2.5","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.636689186096191}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.2.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.256861209869385}},"branch_attrs":{"mutations":{"nuc":["C6968T"]}}},{"name":"XBB.2.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.545039176940918}},"branch_attrs":{"mutations":{"nuc":["T3A","G6344A","A21231G","T23018C","T29859C","G29862-","A29863-","G29864-","A29865-","A29866-","T29867A"],"S":["S486P"],"nsp3":["V1209I"]},"labels":{"aa":"S: S486P; nsp3: V1209I","spike_mutations":"S486P"}}},{"name":"NODE_0000081","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.11"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.454007148742676}},"branch_attrs":{"mutations":{"nuc":["C18129T"]}},"children":[{"name":"XBB.2.11.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.21773099899292}},"branch_attrs":{"mutations":{"nuc":["C4084T","C9559T","T16521C","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}}},{"name":"XBB.2.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.454007148742676}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000082","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.7"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{"nuc":["G11250A"],"nsp6":["R93H"]},"labels":{"aa":"nsp6: R93H"}},"children":[{"name":"XBB.2.7.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65097"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1015C","C12400T","C20316T","A22920T","A22994C"],"S":["Y453F","K478Q"],"nsp2":["E70D"]},"labels":{"aa":"S: Y453F, K478Q; nsp2: E70D","spike_mutations":"Y453F, K478Q"}}},{"name":"XBB.2.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.219924449920654}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000083","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.832684516906738}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"XBB.2.10","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G21718T","A22531G","T28912C"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"NODE_0000084","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5236G","C21812T"]}},"children":[{"name":"XBB.2.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23853G"],"S":["K764R"]},"labels":{"aa":"S: K764R","spike_mutations":"K764R"}}},{"name":"XBB.2.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29642T","T29855A"],"ORF10":["Q29*"],"S":["Q613H"]},"labels":{"aa":"ORF10: Q29*; S: Q613H","spike_mutations":"Q613H"}}}]}]},{"name":"NODE_0000085","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{"nuc":["T44C","C5144T","T5731A"]}},"children":[{"name":"XBB.2.6","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.6237761974334717}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.6.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A21617C"],"S":["I19L"]},"labels":{"aa":"S: I19L","spike_mutations":"I19L"}}},{"name":"XBB.2.6.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.2.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C222T","C24210T","C25587T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"NODE_0000086","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"GH.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35217"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T6895C","T9148C","A15192C","C28435A"],"ORF9b":["P51Q"]},"labels":{"aa":"ORF9b: P51Q"}}},{"name":"XBB.2.6.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.2.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35217"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.2.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.067753314971924}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000087","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{"nuc":["C4234T","G6536A","C16342T","T23018C","C23123T","C27431T","G29706T"],"ORF7a":["A13V"],"S":["S486P","P521S"],"nsp13":["P36S"],"nsp3":["G1273S"]},"labels":{"aa":"ORF7a: A13V; S: S486P, P521S; nsp13: P36S; nsp3: G1273S","clade":"23E","spike_mutations":"S486P, P521S"}},"children":[{"name":"XBB.2.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.7171785831451416}},"branch_attrs":{"mutations":{}}},{"name":"XBB.2.3.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.583856105804443}},"branch_attrs":{"mutations":{"nuc":["T44C","C6031T","C11824T","G14188A","G19254A","G21800T","C27532T"],"ORF7a":["H47Y"],"S":["D80Y"],"nsp12":["A250T"]},"labels":{"aa":"ORF7a: H47Y; S: D80Y; nsp12: A250T","spike_mutations":"D80Y"}}},{"name":"XBB.2.3.14","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.14"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.900241374969482}},"branch_attrs":{"mutations":{"nuc":["G3259T"],"nsp3":["Q180H"]},"labels":{"aa":"nsp3: Q180H"}}},{"name":"XBB.2.3.18","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.2.3.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0750199999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2567103717994188"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.18"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10852C","A18702G","T18996A","A22910G","T22930A","A25253G","C27450T","C27879T","C29296T"],"ORF7b":["H42Y"],"S":["N450D","F456L","T1231A"]},"labels":{"aa":"ORF7b: H42Y; S: N450D, F456L, T1231A","spike_mutations":"N450D, F456L, T1231A"}}},{"name":"XBB.2.3.20","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.20"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T18882C","A22190-","T22191-","T22192-","T27992A","G29072T"],"N":["A267S"],"S":["I210-"]},"labels":{"aa":"N: A267S; S: I210-","spike_mutations":"I210-"}}},{"name":"XBB.2.3.21","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.2.3.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.21"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G670T","C2119T","G9389A","C13959T","G14712T","C24210T","C25797T"],"S":["T883I"],"nsp1":["R135S"],"nsp4":["D279N"]},"labels":{"aa":"S: T883I; nsp1: R135S; nsp4: D279N","spike_mutations":"T883I"}}},{"name":"XBB.2.3.22","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.22"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","T24371A","C27389T","A28174C"],"ORF8":["K94T"],"S":["S937T"]},"labels":{"aa":"ORF8: K94T; S: S937T","spike_mutations":"S937T"}}},{"name":"XBB.2.3.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84876"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.423677444458008}},"branch_attrs":{"mutations":{"nuc":["C18570T","A22996T"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.7","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.456076622009277}},"branch_attrs":{"mutations":{"nuc":["C12525T"],"nsp8":["T145I"]},"labels":{"aa":"nsp8: T145I"}}},{"name":"XBB.2.3.9","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.9"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C18744T","C19200T","C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"internal_79cf744b","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.4"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{"nuc":["T44C","A22994C"],"S":["K478Q"]},"labels":{"aa":"S: K478Q","spike_mutations":"K478Q"}},"children":[{"name":"GZ.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.92117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.711173057556152}},"branch_attrs":{"mutations":{"nuc":["C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"XBB.2.3.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.92117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.675188064575195}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_adf2a409","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.13"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"nsp3":["T1004I"]},"labels":{"aa":"nsp3: T1004I"}},"children":[{"name":"JA.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"JA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13359999999999994"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.861839294433594}},"branch_attrs":{"mutations":{"nuc":["T22928C","C29870A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"XBB.2.3.13","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.13"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.863343715667725}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_db218ab3","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.12"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.036585330963135}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"JU.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"JU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84789"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0527558336884004"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.918222427368164}},"branch_attrs":{"mutations":{"nuc":["A22005C","A22215G","A22910G","C28473T","G29800A"],"N":["P67L"],"ORF9b":["L64F"],"S":["N148T","Q218R","N450D"]},"labels":{"aa":"N: P67L; ORF9b: L64F; S: N148T, Q218R, N450D","spike_mutations":"N148T, Q218R, N450D"}}},{"name":"XBB.2.3.12","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90647"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.12"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.90196418762207}},"branch_attrs":{"mutations":{"nuc":["A22102G","T28066C"],"ORF8":["I58T"]},"labels":{"aa":"ORF8: I58T"}}}]},{"name":"internal_653955d9","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C8266T","G8984A"],"nsp4":["D144N"]},"labels":{"aa":"nsp4: D144N"}},"children":[{"name":"XBB.2.3.16","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.84876"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.16"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A22996C"],"S":["K478N"]},"labels":{"aa":"S: K478N","spike_mutations":"K478N"}}},{"name":"XBB.2.3.17","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89912"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.17"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T14046G","C17976T","A22910G","G26155-","T26156-","T26157-"],"ORF3a":["V255-"],"S":["N450D"]},"labels":{"aa":"ORF3a: V255-; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_895420ac","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.15"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{"nuc":["A13187G"],"nsp10":["I55V"]},"labels":{"aa":"nsp10: I55V"}},"children":[{"name":"JS.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"JS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.907259464263916}},"branch_attrs":{"mutations":{"nuc":["G11272T","C22530T"],"S":["T323I"],"nsp6":["M100I"]},"labels":{"aa":"S: T323I; nsp6: M100I","spike_mutations":"T323I"}}},{"name":"JS.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"JS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T22328A"],"S":["S256T"]},"labels":{"aa":"S: S256T","spike_mutations":"S256T"}}},{"name":"XBB.2.3.15","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.15"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.951463222503662}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_374c620c","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.19"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C5622T","C7303A","G22113T"],"S":["G184V"],"nsp3":["P968L"]},"labels":{"aa":"S: G184V; nsp3: P968L","spike_mutations":"G184V"}},"children":[{"name":"XBB.2.3.19","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{}}},{"name":"internal_cbee2496","node_attrs":{"div":105,"Nextclade_pango":{"value":"JY.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","C10776T","A21203G","C22624T","A22995C","G23522A"],"S":["K478T","E654K"],"nsp16":["K182R"],"nsp5":["P241L"]},"labels":{"aa":"S: K478T, E654K; nsp16: K182R; nsp5: P241L","spike_mutations":"K478T, E654K"}},"children":[{"name":"JY.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.88039"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{}}},{"name":"JY.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.88039"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.19.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C24912A","C27494T"],"ORF7a":["P34L"],"S":["T1117K"]},"labels":{"aa":"ORF7a: P34L; S: T1117K","spike_mutations":"T1117K"}}}]}]},{"name":"internal_560e5d25","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.6"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C1063T","C7105T","T22843C","C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}},"children":[{"name":"GM.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T23269C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"GM.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.972652912139893}},"branch_attrs":{"mutations":{"nuc":["G22103C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"XBB.2.3.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"internal_0d35f655","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G12315A"],"nsp8":["R75K"]},"labels":{"aa":"nsp8: R75K"}},"children":[{"name":"GM.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"GM.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GM.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89932"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736186906064397"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.6.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9561T","T22726A","G26834T"],"S":["N388K"],"nsp4":["S336L"]},"labels":{"aa":"S: N388K; nsp4: S336L","spike_mutations":"N388K"}}}]}]},{"name":"internal_cce192fd","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C2013T","C11750T","T16389C","A22995G"],"S":["K478R"],"nsp2":["A403V"],"nsp6":["L260F"]},"labels":{"aa":"S: K478R; nsp2: A403V; nsp6: L260F","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.8","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"internal_77ab5f52","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.9712977409362793}},"branch_attrs":{"mutations":{"nuc":["A8621G"],"nsp4":["I23V"]},"labels":{"aa":"nsp4: I23V"}},"children":[{"name":"HG.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"HG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C7083T","C22326T"],"S":["S255F"],"nsp3":["S1455F"]},"labels":{"aa":"S: S255F; nsp3: S1455F","spike_mutations":"S255F"}}},{"name":"HG.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"HG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C8950T","C22338T","T25496C"],"ORF3a":["I35T"],"S":["T259I"]},"labels":{"aa":"ORF3a: I35T; S: T259I","spike_mutations":"T259I"}}},{"name":"internal_1fee65b5","node_attrs":{"div":102,"Nextclade_pango":{"value":"HG.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}},"children":[{"name":"HG.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"HG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HG.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HG.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.8.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C17766T","G25130T"],"S":["A1190S"]},"labels":{"aa":"S: A1190S","spike_mutations":"A1190S"}}}]}]}]},{"name":"internal_0a853857","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.2.3.11","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.647791385650635}},"branch_attrs":{"mutations":{}}},{"name":"internal_aa639495","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.781737804412842}},"branch_attrs":{"mutations":{"nuc":["T16389C"]}},"children":[{"name":"GS.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7709600000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0079043361863298"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.985508441925049}},"branch_attrs":{"mutations":{"nuc":["C22971A"],"S":["T470N"]},"labels":{"aa":"S: T470N","spike_mutations":"T470N"}}},{"name":"GS.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10156T","C12596T","T15669C","T22618G","A25927G","G29543C"],"ORF3a":["I179V"],"nsp8":["L169F"]},"labels":{"aa":"ORF3a: I179V; nsp8: L169F"}}}]},{"name":"NODE_0000102","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.762627601623535}},"branch_attrs":{"mutations":{"nuc":["C4582T","C25075T"]}},"children":[{"name":"GS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.295290470123291}},"branch_attrs":{"mutations":{"nuc":["T2C","G22201T"],"S":["E213D"]},"labels":{"aa":"S: E213D","spike_mutations":"E213D"}}},{"name":"GS.6","node_attrs":{"div":110,"Nextclade_pango":{"value":"GS.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A605G","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","T8156C","G9761A","G14400A","C15182T","C16726T","C17274T","T19839C","C21812T","C23275T","G24095T"],"S":["A845S"],"nsp1":["I114V"],"nsp12":["A581V"],"nsp13":["H164Y"],"nsp3":["K394-","P395-","F396-","S1813P"],"nsp4":["V403I"]},"labels":{"aa":"S: A845S; nsp1: I114V; nsp12: A581V; nsp13: H164Y; nsp3: K394-, P395-, F396-, S1813P; nsp4: V403I","spike_mutations":"A845S"}}}]},{"name":"NODE_0000103","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.607783794403076}},"branch_attrs":{"mutations":{"nuc":["C13608T"]}},"children":[{"name":"GS.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GS.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.5518035888671875}},"branch_attrs":{"mutations":{"nuc":["C21T","T20455C","G22132T"],"S":["R190S"],"nsp15":["F279L"]},"labels":{"aa":"S: R190S; nsp15: F279L","spike_mutations":"R190S"}}},{"name":"internal_1f149e33","node_attrs":{"div":100,"Nextclade_pango":{"value":"GS.7"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{"nuc":["C875A","C14925T"],"nsp2":["L24I"]},"labels":{"aa":"nsp2: L24I"}},"children":[{"name":"GS.7.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"GS.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","G1820A","T7576C","A8062G","G16065A","G20679T","G22100C","A23941G","C25509T","A28792T"],"S":["E180Q"],"nsp2":["G339S"]},"labels":{"aa":"S: E180Q; nsp2: G339S","spike_mutations":"E180Q"}}},{"name":"GS.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"GS.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.293886184692383}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000105","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.11"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C26833T","G28371C"],"M":["A104V"],"N":["G30-","-33A"],"ORF9b":["V30L"]},"labels":{"aa":"M: A104V; N: G30-, -33A; ORF9b: V30L"}},"children":[{"name":"GS.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5730T","T7549C","G22216T"],"S":["Q218H"],"nsp3":["T1004I"]},"labels":{"aa":"S: Q218H; nsp3: T1004I","spike_mutations":"Q218H"}}},{"name":"internal_8d5e6c2c","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.4"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{"nuc":["G806A","G14268A","C25701T"],"nsp2":["A1T"]},"labels":{"aa":"nsp2: A1T"}},"children":[{"name":"GS.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"GS.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.636651992797852}},"branch_attrs":{"mutations":{}}},{"name":"internal_4fa3eb54","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.4.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{"nuc":["A22115G","G25906T"],"ORF3a":["G172C"],"S":["N185D"]},"labels":{"aa":"ORF3a: G172C; S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GS.4.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GS.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8030641078948975}},"branch_attrs":{"mutations":{}}},{"name":"GS.4.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GS.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.11.4.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.517807960510254}},"branch_attrs":{"mutations":{"nuc":["C218T","C23243T","G28423T"],"ORF9b":["R47L"],"S":["P561S"]},"labels":{"aa":"ORF9b: R47L; S: P561S","spike_mutations":"P561S"}}}]}]}]}]},{"name":"internal_28f53f8c","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{"nuc":["T44C","C6740T","G22113T"],"S":["G184V"],"nsp3":["R1341W"]},"labels":{"aa":"S: G184V; nsp3: R1341W","spike_mutations":"G184V"}},"children":[{"name":"HH.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"HH.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C5628T"],"nsp3":["T970M"]},"labels":{"aa":"nsp3: T970M"}}},{"name":"XBB.2.3.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.704748153686523}},"branch_attrs":{"mutations":{}}},{"name":"internal_3673174e","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C7162T"]}},"children":[{"name":"HH.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"HH.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1142A","C12854T","A22003T","C27092T","C27970T"],"ORF8":["T26I"],"S":["K147N"],"nsp2":["L113I"],"nsp9":["P57S"]},"labels":{"aa":"ORF8: T26I; S: K147N; nsp2: L113I; nsp9: P57S","spike_mutations":"K147N"}}},{"name":"HH.6","node_attrs":{"div":106,"Nextclade_pango":{"value":"HH.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3070A","G8368T","T19026C","A22995G","A26675G","G27915A"],"ORF8":["G8R"],"S":["K478R"],"nsp3":["D117E"]},"labels":{"aa":"ORF8: G8R; S: K478R; nsp3: D117E","spike_mutations":"K478R"}}}]},{"name":"internal_5a805e2a","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.8"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A23382G","C28657T"],"S":["Q607R"]},"labels":{"aa":"S: Q607R","spike_mutations":"Q607R"}},"children":[{"name":"HH.8","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"HH.8.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HH.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.8.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A3193G","A22995G","A28254-"],"ORF8":["I121-"],"S":["K478R"]},"labels":{"aa":"ORF8: I121-; S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0000111","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-6.45186710357666}},"branch_attrs":{"mutations":{"nuc":["G24193A"]}},"children":[{"name":"HH.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.377432346343994}},"branch_attrs":{"mutations":{"nuc":["G24095T","G25793A"],"ORF3a":["R134H"],"S":["A845S"]},"labels":{"aa":"ORF3a: R134H; S: A845S","spike_mutations":"A845S"}}},{"name":"internal_bb69915a","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.2.3.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.068207740783691}},"branch_attrs":{"mutations":{"nuc":["C26228A"]}},"children":[{"name":"HH.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.174606800079346}},"branch_attrs":{"mutations":{"nuc":["C22564T","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"internal_818ae7ea","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{"nuc":["C9195T","T20697C"],"nsp4":["T214I"]},"labels":{"aa":"nsp4: T214I"}},"children":[{"name":"HH.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.185103893280029}},"branch_attrs":{"mutations":{}}},{"name":"HH.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HH.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C13860T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}}]},{"name":"internal_a5f1c7ea","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["G407T"],"nsp1":["D48Y"]},"labels":{"aa":"nsp1: D48Y"}},"children":[{"name":"HH.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"HH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{}}},{"name":"HH.2.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"HH.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.2.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C44T","G9973A","C10296T","C21077T","A22995G"],"S":["K478R"],"nsp16":["T140I"],"nsp5":["S81F"]},"labels":{"aa":"S: K478R; nsp16: T140I; nsp5: S81F","spike_mutations":"K478R"}}}]}]}]}]},{"name":"internal_e9e2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.10"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{"nuc":["T5947C","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-"]}},"children":[{"name":"XBB.2.3.10","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.43697452545166}},"branch_attrs":{"mutations":{}}},{"name":"internal_4477c590","node_attrs":{"div":98,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{"nuc":["A22116-","T22117-","T22118-","A22995G"],"S":["N185-","F186I","K478R"]},"labels":{"aa":"S: N185-, F186I, K478R","spike_mutations":"N185-, F186I, K478R"}},"children":[{"name":"GE.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.91806697845459}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000117","node_attrs":{"div":99,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.8266634941101074}},"branch_attrs":{"mutations":{"nuc":["A17674G","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"nsp13":["I480V"]},"labels":{"aa":"nsp13: I480V"}},"children":[{"name":"GE.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"GE.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C10340T","A10912G"],"nsp5":["P96S"]},"labels":{"aa":"nsp5: P96S"}}},{"name":"GE.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C23757T","T24127C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"GE.1.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"GE.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["G6352A","C11653T","T16242A"]}}}]},{"name":"internal_d2763520","node_attrs":{"div":100,"Nextclade_pango":{"value":"GE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.00916051864624}},"branch_attrs":{"mutations":{"nuc":["C601T","G2246A"],"nsp2":["G481S"]},"labels":{"aa":"nsp2: G481S"}},"children":[{"name":"GE.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G23222A","C27476T","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF7a":["T28I"],"S":["E554K"]},"labels":{"aa":"ORF7a: T28I; S: E554K","spike_mutations":"E554K"}}},{"name":"GE.1.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C6361T","C10228T","G12707A","C21914A","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"S":["L118I"],"nsp9":["A8T"]},"labels":{"aa":"S: L118I; nsp9: A8T","spike_mutations":"L118I"}}},{"name":"NODE_0000119","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6026T","T13371C","A22005C","C27688T"],"ORF7a":["P99S"],"S":["N148T"],"nsp10":["V116A"],"nsp3":["P1103S"]},"labels":{"aa":"ORF7a: P99S; S: N148T; nsp10: V116A; nsp3: P1103S","spike_mutations":"N148T"}},"children":[{"name":"GE.1.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"GE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"GE.1.2.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"GE.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.70075"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.986824739722089"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C15017T","C19164A","G22785A","T27383A","C27384T","T27810C"],"ORF6":["L61H"],"ORF7b":["F19L"],"S":["S408N"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp12":["A526V"],"nsp14":["D375E"]},"labels":{"aa":"ORF6: L61H; ORF7b: F19L; S: S408N; nsp1: G82-, H83-, V84-, M85-, V86-; nsp12: A526V; nsp14: D375E","spike_mutations":"S408N"}}},{"name":"NODE_0000120","node_attrs":{"div":107,"Nextclade_pango":{"value":"GE.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22688T","G22995C","C25976G"],"ORF3a":["S195C"],"S":["A376S","R478T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF3a: S195C; S: A376S, R478T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"A376S, R478T"}},"children":[{"name":"GE.1.2.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GE.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000121","node_attrs":{"div":111,"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A21792G","T27383A","C27384T","T27688C","-29857C","-29858T","-29859T","-29860A","-29861G","-29862G","-29863A","-29864G","-29865A"],"ORF6":["L61H"],"ORF7a":["S99P"],"S":["K77R"]},"labels":{"aa":"ORF6: L61H; ORF7a: S99P; S: K77R","spike_mutations":"K77R"}},"children":[{"name":"KT.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"KT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000122","node_attrs":{"div":112,"Nextclade_pango":{"value":"KT.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T27431C"],"ORF7a":["V13A"]},"labels":{"aa":"ORF7a: V13A"}},"children":[{"name":"KT.1.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KT.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C683T","G15957A"]}}},{"name":"KT.1.2","node_attrs":{"div":114,"Nextclade_pango":{"value":"KT.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95933"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9661216382902195"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.10.1.2.1.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C583T","A20450G"],"nsp15":["N277S"]},"labels":{"aa":"nsp15: N277S"}}}]}]}]}]}]}]}]},{"name":"NODE_0000123","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{"nuc":["A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}},"children":[{"name":"GJ.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1060T","G22021A","T24892C"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"XBB.2.3.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.2.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.2578043937683105}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000124","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.2.3.3"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.2036452293396}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"GJ.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C313T","C3176T","G20578T"],"nsp15":["V320L"],"nsp3":["P153S"]},"labels":{"aa":"nsp15: V320L; nsp3: P153S"}}},{"name":"GJ.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T44C","T14295C","C15848T","T24903G"],"S":["I1114S"],"nsp12":["T803I"]},"labels":{"aa":"S: I1114S; nsp12: T803I","spike_mutations":"I1114S"}}},{"name":"GJ.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"GJ.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13359999999999994"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1722153044473287"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2937T","A5706G","T22930A","G26538A"],"M":["G6S"],"S":["F456L"],"nsp3":["T73I","Y996C"]},"labels":{"aa":"M: G6S; S: F456L; nsp3: T73I, Y996C","spike_mutations":"F456L"}}},{"name":"GJ.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C18646T","G22109A"],"S":["E183K"],"nsp14":["P203S"]},"labels":{"aa":"S: E183K; nsp14: P203S","spike_mutations":"E183K"}}},{"name":"internal_27e82a71","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.5"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A11794G","C13138T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"GJ.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"GJ.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.5.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C1884T","C12153T","C22326T"],"S":["S255F"],"nsp2":["A360V"],"nsp8":["A21V"]},"labels":{"aa":"S: S255F; nsp2: A360V; nsp8: A21V","spike_mutations":"S255F"}}}]},{"name":"internal_91d6f56e","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12878G","G28209C"],"ORF8":["E106Q"],"nsp9":["I65V"]},"labels":{"aa":"ORF8: E106Q; nsp9: I65V"}},"children":[{"name":"GJ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_bb60c15c","node_attrs":{"div":101,"Nextclade_pango":{"value":"GJ.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1549T"]}},"children":[{"name":"GJ.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C1150T","C2902T","A3394T","G6008A","A6948G","C22227T","G29229A"],"N":["R319H"],"S":["A222V"],"nsp3":["V1097I","N1410S"]},"labels":{"aa":"N: R319H; S: A222V; nsp3: V1097I, N1410S","spike_mutations":"A222V"}}},{"name":"internal_a7d6c359","node_attrs":{"div":103,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{"nuc":["C7819G","G16795A"],"nsp13":["V187I"]},"labels":{"aa":"nsp13: V187I"}},"children":[{"name":"GJ.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"GJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.077783107757568}},"branch_attrs":{"mutations":{}}},{"name":"GJ.1.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GJ.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G3719T","A22995G","T28297C","T29068C"],"ORF9b":["I5T"],"S":["K478R"],"nsp3":["G334C"]},"labels":{"aa":"ORF9b: I5T; S: K478R; nsp3: G334C","spike_mutations":"K478R"}}},{"name":"GJ.1.2.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.8"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T1930G","C23802T","G25690T"],"ORF3a":["G100C"],"S":["T747I"]},"labels":{"aa":"ORF3a: G100C; S: T747I","spike_mutations":"T747I"}}},{"name":"internal_eafb7d93","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C3020T"],"nsp3":["H101Y"]},"labels":{"aa":"nsp3: H101Y"}},"children":[{"name":"GJ.1.2.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"GJ.1.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.4"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","A6739G","G6744A","C22326T","G27916T"],"ORF8":["G8V"],"S":["S255F"],"nsp3":["C1342Y"]},"labels":{"aa":"ORF8: G8V; S: S255F; nsp3: C1342Y","spike_mutations":"S255F"}}},{"name":"GJ.1.2.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.7"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T6511C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_03bb8549","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-3.765152931213379}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"nsp13":["S74P"]},"labels":{"aa":"nsp13: S74P"}},"children":[{"name":"GJ.1.2.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.3"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21789T","C28344T"],"N":["T24I"],"S":["T76I"]},"labels":{"aa":"N: T24I; S: T76I","spike_mutations":"T76I"}}},{"name":"GJ.1.2.6","node_attrs":{"div":105,"Nextclade_pango":{"value":"GJ.1.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.6"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.4524970054626465}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"GJ.1.2.5","node_attrs":{"div":106,"Nextclade_pango":{"value":"GJ.1.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.5"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24062G","G27047A"],"S":["I834V"]},"labels":{"aa":"S: I834V","spike_mutations":"I834V"}}}]},{"name":"internal_18110768","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}},"children":[{"name":"GJ.1.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GJ.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89912"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0248043607383275"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"internal_2e22628a","node_attrs":{"div":108,"Nextclade_pango":{"value":"JE.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C14805T","A22995G","C25521T","C26885T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JE.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"JE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000133","node_attrs":{"div":109,"Nextclade_pango":{"value":"JE.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{"nuc":["A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}},"children":[{"name":"JE.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.325514316558838}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000134","node_attrs":{"div":110,"Nextclade_pango":{"value":"JE.1.1.1"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{"nuc":["T24927C"],"S":["V1122A"]},"labels":{"aa":"S: V1122A","spike_mutations":"V1122A"}},"children":[{"name":"JE.1.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"JE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-5.106734752655029}},"branch_attrs":{"mutations":{}}},{"name":"KH.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"KH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.75251"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0453841240781256"},"clade_display":{"value":"23E (XBB.2.3)"},"partiallyAliased":{"value":"XBB.2.3.3.1.2.1.1.1.1.1"},"clade_nextstrain":{"value":"23E"},"clade_membership":{"value":"23E"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["G670T","G12274A","G23222A","G27604T","C28310T"],"N":["L13F"],"ORF7a":["V71L"],"S":["E554K"],"nsp1":["R135S"]},"labels":{"aa":"N: L13F; ORF7a: V71L; S: E554K; nsp1: R135S","spike_mutations":"E554K"}}}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000135","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.0628252029418945}},"branch_attrs":{"mutations":{"nuc":["G22317T"],"S":["G252V"]},"labels":{"aa":"S: G252V","spike_mutations":"G252V"}},"children":[{"name":"XBB.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"XBB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.0628252029418945}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.10","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13558"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C64T","C11653T","C21575T","G22770A","C24117T","C29580T"],"ORF10":["A8V"],"S":["L5F","R403K","A852V"]},"labels":{"aa":"ORF10: A8V; S: L5F, R403K, A852V","spike_mutations":"L5F, R403K, A852V"}}},{"name":"XBB.1.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49564"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.381251335144043}},"branch_attrs":{"mutations":{"nuc":["C7124T","G23012A"],"S":["A484T"],"nsp3":["P1469S"]},"labels":{"aa":"S: A484T; nsp3: P1469S","spike_mutations":"A484T"}}},{"name":"NODE_0000136","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.090980529785156}},"branch_attrs":{"mutations":{"nuc":["C16648A","T23018C","A27965G"],"S":["S486P"],"nsp13":["L138I"]},"labels":{"aa":"S: S486P; nsp13: L138I","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.33","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0545"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.33"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G149C","G515-","T516-","T517-","A518-","T519-","G520-","C5259T","A7722C","C18555T","T21201C","G22688A","A24452G","C27619T","G28109T"],"ORF7a":["Q76*"],"ORF8":["Q72H"],"S":["A376T","K964E"],"nsp1":["V84-","M85-"],"nsp3":["T847I","Q1668P"]},"labels":{"aa":"ORF7a: Q76*; ORF8: Q72H; S: A376T, K964E; nsp1: V84-, M85-; nsp3: T847I, Q1668P","spike_mutations":"A376T, K964E"}}},{"name":"XBB.1.49","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89405"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.49"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C635T","C9073T","A22598T"],"S":["T346S"],"nsp1":["R124C"]},"labels":{"aa":"S: T346S; nsp1: R124C","spike_mutations":"T346S"}}}]},{"name":"internal_XBB_1_541T","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.541812419891357}},"branch_attrs":{"mutations":{"nuc":["C541T"]}},"children":[{"name":"XBB.1.20","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.20"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3130T","C13199A","T20175C","C25607T"],"ORF3a":["A72V"],"nsp10":["P59T"]},"labels":{"aa":"ORF3a: A72V; nsp10: P59T"}}},{"name":"XBB.1.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.9722600000000003"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.48"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-7.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T44C","C2509T","G22927T","T22928C","T27531C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"NODE_0000138","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.19"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{"nuc":["A10042G","T21363C","T23018C","G29810T"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.19","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.3401079177856445}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.19.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.19.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6471T","C7420T","C23123T","C28603T","G29254A"],"S":["P521S"],"nsp3":["T1251I"]},"labels":{"aa":"S: P521S; nsp3: T1251I","spike_mutations":"P521S"}}},{"name":"NODE_0000139","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.19.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["T44C","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GW.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5178T","C6401T","T8662C","T15300C","A24369G","G25641A"],"S":["D936G"],"nsp3":["T820I","P1228S"]},"labels":{"aa":"S: D936G; nsp3: T820I, P1228S","spike_mutations":"D936G"}}},{"name":"GW.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"GW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G564A","A10875G"],"nsp1":["S100N"],"nsp5":["N274S"]},"labels":{"aa":"nsp1: S100N; nsp5: N274S"}}},{"name":"GW.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"GW.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G10105T"],"nsp5":["M17I"]},"labels":{"aa":"nsp5: M17I"}}},{"name":"XBB.1.19.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000140","node_attrs":{"div":103,"Nextclade_pango":{"value":"GW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["G1055A","C10186T","G10465A","C15960T","C20823T","C28519T","A29237G"],"N":["M322V"],"ORF9b":["T79I"],"nsp2":["D84N"]},"labels":{"aa":"N: M322V; ORF9b: T79I; nsp2: D84N"}},"children":[{"name":"GW.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"GW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{}}},{"name":"GW.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A21137G","T22928C"],"S":["F456L"],"nsp16":["K160R"]},"labels":{"aa":"S: F456L; nsp16: K160R","spike_mutations":"F456L"}}}]},{"name":"NODE_0000141","node_attrs":{"div":108,"Nextclade_pango":{"value":"GW.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{"nuc":["C44T","C1170T","C6501A","C12473T","C12924T","G22927T","T22928C","A22995T","C24034T","T24046C","C28511T","T28723C"],"N":["P80S"],"S":["L455F","F456L","K478I"],"nsp2":["S122F"],"nsp3":["P1261Q"],"nsp9":["P80L"]},"labels":{"aa":"N: P80S; S: L455F, F456L, K478I; nsp2: S122F; nsp3: P1261Q; nsp9: P80L","spike_mutations":"L455F, F456L, K478I"}},"children":[{"name":"GW.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"GW.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G9190A","C29409T"],"N":["T379I"]},"labels":{"aa":"N: T379I"}}},{"name":"NODE_0000142","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T20310C","C28519T"],"ORF9b":["T79I"]},"labels":{"aa":"ORF9b: T79I"}},"children":[{"name":"GW.5.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"GW.5.3.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"GW.5.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["A2345G","C20806T","G22113C","C22986T"],"S":["G184A","A475V"],"nsp2":["I514V"]},"labels":{"aa":"S: G184A, A475V; nsp2: I514V","spike_mutations":"G184A, A475V"}}}]},{"name":"NODE_0000143","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G25839T","A28768G"],"ORF3a":["W149C"]},"labels":{"aa":"ORF3a: W149C"}},"children":[{"name":"GW.5.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"GW.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.42535999999999996"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000144","node_attrs":{"div":116,"Nextclade_pango":{"value":"GW.5.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C450T","T21798C","C22986T","G25906T","T27383A","C27384T"],"ORF3a":["G172C"],"ORF6":["L61H"],"S":["F79S","A475V"],"nsp1":["P62L"]},"labels":{"aa":"ORF3a: G172C; ORF6: L61H; S: F79S, A475V; nsp1: P62L","spike_mutations":"F79S, A475V"}},"children":[{"name":"GW.5.1.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"GW.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"KE.1","node_attrs":{"div":121,"Nextclade_pango":{"value":"KE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C18060T","T22119C","C25665T","T27395A","C27431T"],"ORF7a":["M1K","A13V"],"S":["F186S"]},"labels":{"aa":"ORF7a: M1K, A13V; S: F186S","spike_mutations":"F186S"}}},{"name":"KE.2","node_attrs":{"div":121,"Nextclade_pango":{"value":"KE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8016T","C12781T","T15252G","C23673T","C29762T"],"S":["S704L"],"nsp3":["A1766V"]},"labels":{"aa":"S: S704L; nsp3: A1766V","spike_mutations":"S704L"}}},{"name":"KE.3","node_attrs":{"div":118,"Nextclade_pango":{"value":"KE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.19.1.5.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T11187C","C15656T"],"nsp12":["T739I"],"nsp6":["L72S"]},"labels":{"aa":"nsp12: T739I; nsp6: L72S"}}}]}]}]}]}]}]},{"name":"NODE_0000145","node_attrs":{"div":90,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.1273951530456543}},"branch_attrs":{"mutations":{"nuc":["G27915T"],"ORF8":["G8*"]},"labels":{"aa":"ORF8: G8*"}},"children":[{"name":"XBB.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86729"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.21"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4005G","C6196A","C6388T","A20262G","T23018G","-29759G"],"S":["S486A"],"nsp3":["K429R"]},"labels":{"aa":"S: S486A; nsp3: K429R","spike_mutations":"S486A"}}},{"name":"XBB.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2602599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.27"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9803T","C11956T","A13703T","T14211C","A22995G","C24231T"],"S":["K478R","A890V"],"nsp12":["N88I"]},"labels":{"aa":"S: K478R, A890V; nsp12: N88I","spike_mutations":"K478R, A890V"}}},{"name":"XBB.1.29","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.29"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G11114T","C11750T","G22436T"],"S":["A292S"],"nsp6":["G48C","L260F"]},"labels":{"aa":"S: A292S; nsp6: G48C, L260F","spike_mutations":"A292S"}}},{"name":"XBB.1.36","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.36"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.386032581329346}},"branch_attrs":{"mutations":{"nuc":["C4999T","A14427G","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}}},{"name":"XBB.1.40","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.40"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1648T","G1820A","C8090T","C16650T","A22920T","C25162T","C25702T","T26819C"],"ORF3a":["P104S"],"S":["Y453F"],"nsp2":["G339S"],"nsp3":["L1791F"]},"labels":{"aa":"ORF3a: P104S; S: Y453F; nsp2: G339S; nsp3: L1791F","spike_mutations":"Y453F"}}},{"name":"XBB.1.7","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.88502836227417}},"branch_attrs":{"mutations":{"nuc":["T44C","G3418T","G23384A","-29759G"],"S":["V608I"],"nsp3":["K233N"]},"labels":{"aa":"S: V608I; nsp3: K233N","spike_mutations":"V608I"}}},{"name":"XBB.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G2883T","T7825A","C21998A","C22208T"],"S":["Q146K","L216F"],"nsp3":["C55F","H1702Q"]},"labels":{"aa":"S: Q146K, L216F; nsp3: C55F, H1702Q","spike_mutations":"Q146K, L216F"}}},{"name":"XBB.1.8","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393089294433594}},"branch_attrs":{"mutations":{"nuc":["T44C","C3241T"]}}},{"name":"NODE_0000146","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.12"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C912T","C8760T","C11956T","T14217A","G14218A","A15367G","A22920T"],"S":["Y453F"],"nsp12":["D260N","T643A"],"nsp2":["S36F"],"nsp4":["A69V"]},"labels":{"aa":"S: Y453F; nsp12: D260N, T643A; nsp2: S36F; nsp4: A69V","spike_mutations":"Y453F"}},"children":[{"name":"XBB.1.12","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.12.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.12.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2106T","C5512T","G23401T","G25166C"],"S":["Q613H","E1202Q"],"nsp2":["T434I"]},"labels":{"aa":"S: Q613H, E1202Q; nsp2: T434I","spike_mutations":"Q613H, E1202Q"}}}]},{"name":"internal_32defdcb","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.13"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.727348327636719}},"branch_attrs":{"mutations":{"nuc":["T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"XBB.1.13","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.727348327636719}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.13.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18493000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.13.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6821G","C23252G","C24130G","C26996T","C28732T"],"S":["Q564E","N856K"],"nsp3":["T1368A"]},"labels":{"aa":"S: Q564E, N856K; nsp3: T1368A","spike_mutations":"Q564E, N856K"}}}]},{"name":"NODE_0000148","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.14"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G5515T","C15810T","G21786T","G23222A"],"S":["G75V","E554K"]},"labels":{"aa":"S: G75V, E554K","spike_mutations":"G75V, E554K"}},"children":[{"name":"XBB.1.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.14.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.14.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A15483G","A22005C","G28904T"],"N":["A211S"],"S":["N148T"]},"labels":{"aa":"N: A211S; S: N148T","spike_mutations":"N148T"}}}]},{"name":"internal_7bf43f6c","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.15"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{"nuc":["C1884T"],"nsp2":["A360V"]},"labels":{"aa":"nsp2: A360V"}},"children":[{"name":"XBB.1.15.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C9803T","A19464G","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.15","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.15"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.7926182746887207}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_234859ae","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.38"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.930898189544678}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}},"children":[{"name":"XBB.1.38","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.930898189544678}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.38.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.38.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.071078300476074}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}}]},{"name":"internal_8d12","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.37"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.231898784637451}},"branch_attrs":{"mutations":{"nuc":["A5371G"]}},"children":[{"name":"XBB.1.37.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.37.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A1846G","G7459T","T23018C","T27285C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.37","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.37"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.231898784637451}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_97a057d5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.43"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.254012107849121}},"branch_attrs":{"mutations":{"nuc":["T44C","G11071A"]}},"children":[{"name":"XBB.1.43.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8127T","A20713C","T23018C"],"S":["S486P"],"nsp3":["A1803V"]},"labels":{"aa":"S: S486P; nsp3: A1803V","spike_mutations":"S486P"}}},{"name":"XBB.1.43","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.43"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.254012107849121}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}}]},{"name":"internal_fcda1063","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.44"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{"nuc":["C21306T","C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}},"children":[{"name":"XBB.1.44","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345211982727051}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.44.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.44.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.44.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1884T","G4720T","T23018C","C25976T"],"ORF3a":["S195F"],"S":["S486P"],"nsp2":["A360V"]},"labels":{"aa":"ORF3a: S195F; S: S486P; nsp2: A360V","spike_mutations":"S486P"}}}]},{"name":"internal_8f782cea","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.45"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.039512634277344}},"branch_attrs":{"mutations":{"nuc":["T21000C"]}},"children":[{"name":"XBB.1.45.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.45.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A3139G","A19137G","T23018C","C28291T"],"ORF9b":["P3L"],"S":["S486P"]},"labels":{"aa":"ORF9b: P3L; S: S486P","spike_mutations":"S486P"}}},{"name":"XBB.1.45","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.45"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.039512634277344}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000155","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.31"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{"nuc":["C1191T","G6961T","A14319G","A22920T","A22995G"],"S":["Y453F","K478R"],"nsp2":["P129L"],"nsp3":["W1414C"]},"labels":{"aa":"S: Y453F, K478R; nsp2: P129L; nsp3: W1414C","spike_mutations":"Y453F, K478R"}},"children":[{"name":"XBB.1.31","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.280521869659424}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.31.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3743T","C3832T","G11029T","G23222A","G25981T"],"ORF3a":["V197L"],"S":["E554K"],"nsp3":["H342Y"],"nsp6":["L19F"]},"labels":{"aa":"ORF3a: V197L; S: E554K; nsp3: H342Y; nsp6: L19F","spike_mutations":"E554K"}}},{"name":"XBB.1.31.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.31.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.54089"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.31.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C3411T"],"nsp3":["A231V"]},"labels":{"aa":"nsp3: A231V"}}}]},{"name":"internal_d9591069","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{"nuc":["C24210T","T26160C","-29759G"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"XBB.1.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.715850353240967}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.4.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C346T","C7639T","G11048T","A20553G","T23018C"],"S":["S486P"],"nsp6":["V26F"]},"labels":{"aa":"S: S486P; nsp6: V26F","spike_mutations":"S486P"}}},{"name":"XBB.1.4.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9892520904541016}},"branch_attrs":{"mutations":{"nuc":["G2164A","A23579G","G29759-"],"S":["S673G"]},"labels":{"aa":"S: S673G","spike_mutations":"S673G"}}}]},{"name":"internal_72cf675c","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.34"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C9430T","G16741A","C19017T","C19524T","T23018C","A23604G","C27884T","C28422T"],"N":["A50V"],"ORF9b":["R47C"],"S":["S486P","H681R"],"nsp13":["V169I"]},"labels":{"aa":"N: A50V; ORF9b: R47C; S: S486P, H681R; nsp13: V169I","spike_mutations":"S486P, H681R"}},"children":[{"name":"XBB.1.34","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.34.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C16376T","G23222A"],"S":["E554K"],"nsp13":["P47L"]},"labels":{"aa":"S: E554K; nsp13: P47L","spike_mutations":"E554K"}}},{"name":"internal_5dcf3700","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.34.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3230T","A22107T","G28162T"],"ORF8":["C90F"],"S":["K182I"],"nsp3":["G171C"]},"labels":{"aa":"ORF8: C90F; S: K182I; nsp3: G171C","spike_mutations":"K182I"}},"children":[{"name":"HB.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21998A","T22928C"],"S":["Q146K","F456L"]},"labels":{"aa":"S: Q146K, F456L","spike_mutations":"Q146K, F456L"}}},{"name":"XBB.1.34.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.34.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.34.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000159","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9296858310699463}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.30","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.30"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.753546237945557}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}}},{"name":"XBB.1.39","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.39"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.072872638702393}},"branch_attrs":{"mutations":{"nuc":["G8861A"],"nsp4":["V103M"]},"labels":{"aa":"nsp4: V103M"}}},{"name":"internal_18e1f6df","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.32"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{"nuc":["G709T"],"nsp1":["E148D"]},"labels":{"aa":"nsp1: E148D"}},"children":[{"name":"XBB.1.32.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","C2189T","T3676C","C6627T","T14865C","C20956A","A22920T","G27541T"],"ORF7a":["A50S"],"S":["Y453F"],"nsp16":["L100I"],"nsp2":["L462F"],"nsp3":["T1303I"]},"labels":{"aa":"ORF7a: A50S; S: Y453F; nsp16: L100I; nsp2: L462F; nsp3: T1303I","spike_mutations":"Y453F"}}},{"name":"XBB.1.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.32"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.253849506378174}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_2d8f9114","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1.28"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.579292297363281}},"branch_attrs":{"mutations":{"nuc":["G22770A"],"S":["R403K"]},"labels":{"aa":"S: R403K","spike_mutations":"R403K"}},"children":[{"name":"XBB.1.28","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05231"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-7.162049293518066}},"branch_attrs":{"mutations":{"nuc":["T5263C","G20102T","T22566C"],"S":["L335S"],"nsp15":["S161I"]},"labels":{"aa":"S: L335S; nsp15: S161I","spike_mutations":"L335S"}}},{"name":"NODE_0000162","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.28.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.856406211853027}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FW.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.095174789428711}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","G7037T"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp3":["G1440C"]},"labels":{"aa":"nsp1: G82-, H83-, V84-, M85V; nsp3: G1440C"}}},{"name":"FW.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8140T","T8141C","G8144A","A29320G"],"nsp3":["D1809N"]},"labels":{"aa":"nsp3: D1809N"}}},{"name":"XBB.1.28.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.28.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.856406211853027}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000163","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345422744750977}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C23664T","T27205-"],"ORF6":["F2-"],"S":["A701V"],"nsp1":["V84-","M85-"]},"labels":{"aa":"ORF6: F2-; S: A701V; nsp1: V84-, M85-","spike_mutations":"A701V"}},"children":[{"name":"FW.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"FW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:3-62"},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.345422744750977}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000164","node_attrs":{"div":99,"Nextclade_pango":{"value":"FW.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1978C","G2778A","G13118A","A17809C","A22005C","G27754T"],"ORF7a":["E121*"],"S":["N148T"],"nsp10":["A32T"],"nsp13":["I525L"],"nsp3":["S20N"]},"labels":{"aa":"ORF7a: E121*; S: N148T; nsp10: A32T; nsp13: I525L; nsp3: S20N","spike_mutations":"N148T"}},"children":[{"name":"FW.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:3-62"},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"FW.1.1.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13254"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2584103390429446"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.28.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7119T","C9442T","A10323G","T13728C","G23612A","-27205T","T27383A","C27384T"],"ORF6":["-2F","L61H"],"S":["A684T"],"nsp3":["S1467F"],"nsp5":["K90R"]},"labels":{"aa":"ORF6: -2F, L61H; S: A684T; nsp3: S1467F; nsp5: K90R","spike_mutations":"A684T"}}}]}]}]}]},{"name":"internal_0403","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.11"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["C13968A","G16377A"]}},"children":[{"name":"XBB.1.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.962812423706055}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_df4002f6","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.11.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FP.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.714375019073486}},"branch_attrs":{"mutations":{"nuc":["C6312T","A6616G","-21633T","-21634A","C21642-","A21643-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-"],"S":["-24L","S27-","H69-","V70-"],"nsp3":["T1198I"]},"labels":{"aa":"S: -24L, S27-, H69-, V70-; nsp3: T1198I","spike_mutations":"-24L, S27-, H69-, V70-"}}},{"name":"FP.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.54736328125}},"branch_attrs":{"mutations":{"nuc":["C2536T","C3241T"]}}},{"name":"FP.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"FP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.983648300170898}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.11.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{}}},{"name":"internal_c73e70db","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G9497A","T22119C"],"S":["F186S"],"nsp4":["V315I"]},"labels":{"aa":"S: F186S; nsp4: V315I","spike_mutations":"F186S"}},"children":[{"name":"FP.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000168","node_attrs":{"div":100,"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2281A","T2343C","A3116G","A22995G","G25839T"],"ORF3a":["W149C"],"S":["K478R"],"nsp2":["I513T"],"nsp3":["T133A"]},"labels":{"aa":"ORF3a: W149C; S: K478R; nsp2: I513T; nsp3: T133A","spike_mutations":"K478R"}},"children":[{"name":"FP.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FP.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"NODE_0000169","node_attrs":{"div":101,"Nextclade_pango":{"value":"FP.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.477802753448486}},"branch_attrs":{"mutations":{"nuc":["T15357C"]}},"children":[{"name":"FP.2.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FP.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7388600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"FP.2.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"FP.2.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.11.1.2.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T693A","C23123T"],"S":["P521S"],"nsp1":["F143Y"]},"labels":{"aa":"S: P521S; nsp1: F143Y","spike_mutations":"P521S"}}}]}]}]}]}]},{"name":"internal_T13704C","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.9296858310699463}},"branch_attrs":{"mutations":{"nuc":["T13704C"]}},"children":[{"name":"XBB.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.080835819244385}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"nsp2":["P129L"]},"labels":{"aa":"nsp2: P129L"}}},{"name":"XBB.1.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16111T","C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"XBB.1.35","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.35"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["T531C","C3811T"],"nsp1":["V89A"]},"labels":{"aa":"nsp1: V89A"}}},{"name":"XBB.1.46","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.46"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.214561462402344}},"branch_attrs":{"mutations":{"nuc":["G3606T"],"nsp3":["C296F"]},"labels":{"aa":"nsp3: C296F"}}},{"name":"internal_2a4b7258","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.47"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{"nuc":["T2803C","C5547T","G6804A","A8825G","C27945T"],"ORF8":["Q18*"],"nsp3":["T943I","C1362Y"],"nsp4":["I91V"]},"labels":{"aa":"ORF8: Q18*; nsp3: T943I, C1362Y; nsp4: I91V"}},"children":[{"name":"XBB.1.47","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.90377140045166}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.47.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.47.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.47.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.6733222007751465}},"branch_attrs":{"mutations":{"nuc":["G2272T","C4582T","C22341T","T23018C","T24927G"],"S":["A260V","S486P","V1122G"],"nsp2":["K489N"]},"labels":{"aa":"S: A260V, S486P, V1122G; nsp2: K489N","spike_mutations":"A260V, S486P, V1122G"}}}]},{"name":"NODE_0000172","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A624G","T23018C","C27297A"],"S":["S486P"],"nsp1":["K120R"]},"labels":{"aa":"S: S486P; nsp1: K120R","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.24.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05408"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T23115A"],"S":["L518Q"]},"labels":{"aa":"S: L518Q","spike_mutations":"L518Q"}}},{"name":"XBB.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000173","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.24"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1048T"],"nsp2":["K81N"]},"labels":{"aa":"nsp2: K81N"}},"children":[{"name":"XBB.1.24.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.24.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"XBB.1.24.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.24.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.24.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T15750C","A22036C","G28376A"],"N":["A35T"],"S":["R158S"]},"labels":{"aa":"N: A35T; S: R158S","spike_mutations":"R158S"}}}]}]}]},{"name":"internal_XBB_1_18","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.18"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.696725368499756}},"branch_attrs":{"mutations":{"nuc":["T44C","A8001G"],"nsp3":["D1761G"]},"labels":{"aa":"nsp3: D1761G"}},"children":[{"name":"XBB.1.18","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.696725368499756}},"branch_attrs":{"mutations":{}}},{"name":"internal_29ca1a1d","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.18.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357577800750732}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.18.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357577800750732}},"branch_attrs":{"mutations":{}}},{"name":"internal_44ed5a46","node_attrs":{"div":96,"Nextclade_pango":{"value":"FE.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A3662G","T22928C","T26012G"],"ORF3a":["F207C"],"S":["F456L"],"nsp3":["S315G"]},"labels":{"aa":"ORF3a: F207C; S: F456L; nsp3: S315G","spike_mutations":"F456L"}},"children":[{"name":"FE.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.775372266769409}},"branch_attrs":{"mutations":{"nuc":["A5488G"]}}},{"name":"internal_90d11099","node_attrs":{"div":98,"Nextclade_pango":{"value":"FE.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["T4579A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"FE.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"FE.1.1.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3238C","C11956T","A24819G"],"S":["K1086R"],"nsp3":["Q173H"]},"labels":{"aa":"S: K1086R; nsp3: Q173H","spike_mutations":"K1086R"}}},{"name":"FE.1.1.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["A4336G","T24073C"]}}},{"name":"FE.1.1.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A24775G"]}}},{"name":"FE.1.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"FE.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G23222A","A23233G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000178","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3261T","T3577G","C15180T"],"nsp3":["T181I"]},"labels":{"aa":"nsp3: T181I"}},"children":[{"name":"FE.1.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"internal_8af9e862","node_attrs":{"div":102,"Nextclade_pango":{"value":"FE.1.1.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T9445C"]}},"children":[{"name":"HE.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C15222T","G23426A","C28057T"],"ORF8":["A55V"],"S":["V622I"]},"labels":{"aa":"ORF8: A55V; S: V622I","spike_mutations":"V622I"}}},{"name":"HE.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"HE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.18.1.1.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C24734T","C25703T","T28297C"],"ORF3a":["P104L"],"ORF9b":["I5T"],"S":["H1058Y"]},"labels":{"aa":"ORF3a: P104L; ORF9b: I5T; S: H1058Y","spike_mutations":"H1058Y"}}}]}]}]}]}]}]},{"name":"internal_a480a8b7","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.41"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{"nuc":["C1473T","G20102T","T22566C","G22770A","T23018C"],"S":["L335S","R403K","S486P"],"nsp15":["S161I"],"nsp2":["T223I"]},"labels":{"aa":"S: L335S, R403K, S486P; nsp15: S161I; nsp2: T223I","spike_mutations":"L335S, R403K, S486P"}},"children":[{"name":"XBB.1.41","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65784"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.724045753479004}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.41.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.41.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6066099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1099290580037755"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C9724T","G14023A","C21772T","T23042C","T28636C"],"S":["S494P"],"nsp12":["A195T"]},"labels":{"aa":"S: S494P; nsp12: A195T","spike_mutations":"S494P"}}},{"name":"internal_e264e3bd","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.41.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C17850T","C25276T","C29416G"]}},"children":[{"name":"XBB.1.41.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.41.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.65784"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.079714171690073"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000182","node_attrs":{"div":101,"Nextclade_pango":{"value":"JW.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1454T","C2509T","A22995G"],"S":["K478R"],"nsp2":["L217F"]},"labels":{"aa":"S: K478R; nsp2: L217F","spike_mutations":"K478R"}},"children":[{"name":"JW.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T17065C","C21602A"],"S":["Q14K"],"nsp13":["Y277H"]},"labels":{"aa":"S: Q14K; nsp13: Y277H","spike_mutations":"Q14K"}}},{"name":"JW.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"JW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_4302f45b","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"XBB.1.41.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.41.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.804387092590332}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000184","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.684411525726318}},"branch_attrs":{"mutations":{"nuc":["C364T"]}},"children":[{"name":"JC.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A25241G","G29841-","T29842-","G29843-","A29844-","T29845-","T29846-","T29847-","T29848-","A29849-","A29850-","T29851-","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-"],"S":["I1227V"]},"labels":{"aa":"S: I1227V","spike_mutations":"I1227V"}}},{"name":"NODE_0000185","node_attrs":{"div":102,"Nextclade_pango":{"value":"JC.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T44C","C3924T","C18555T","C29171T","C29769T"],"N":["H300Y"],"nsp3":["P402L"]},"labels":{"aa":"N: H300Y; nsp3: P402L"}},"children":[{"name":"JC.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"JC.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"JC.5.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JC.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G557A","C15660T","C22079A"],"S":["Q173K"],"nsp1":["G98S"]},"labels":{"aa":"S: Q173K; nsp1: G98S","spike_mutations":"Q173K"}}}]}]},{"name":"NODE_0000186","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.41.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["C18877T"]}},"children":[{"name":"JC.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A21792G"],"S":["K77R"]},"labels":{"aa":"S: K77R","spike_mutations":"K77R"}}},{"name":"JC.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"JC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A22005G"],"S":["N148S"]},"labels":{"aa":"S: N148S","spike_mutations":"N148S"}}},{"name":"JC.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"JC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.43418"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["T44C","T1657C","G3431T","A22578G"],"S":["H339R"],"nsp3":["V238L"]},"labels":{"aa":"S: H339R; nsp3: V238L","spike_mutations":"H339R"}}},{"name":"JC.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"JC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.51123"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.100757948723013"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.41.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10336T","A23670T","G29560T"],"ORF10":["M1I"],"S":["N703I"]},"labels":{"aa":"ORF10: M1I; S: N703I","spike_mutations":"N703I"}}}]}]}]},{"name":"internal_XBB_1_17","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.17"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1670T","T27995C"],"nsp2":["L289F"]},"labels":{"aa":"nsp2: L289F"}},"children":[{"name":"XBB.1.17","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.17.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G2357T"],"nsp2":["A518S"]},"labels":{"aa":"nsp2: A518S"}}},{"name":"NODE_0000188","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22205C","T23018C"],"S":["D215H","S486P"]},"labels":{"aa":"S: D215H, S486P","spike_mutations":"D215H, S486P"}},"children":[{"name":"GA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"GA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G2447T"],"nsp2":["G548C"]},"labels":{"aa":"nsp2: G548C"}}},{"name":"XBB.1.17.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000189","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.17.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.089524269104004}},"branch_attrs":{"mutations":{"nuc":["G20173A"],"nsp15":["V185I"]},"labels":{"aa":"nsp15: V185I"}},"children":[{"name":"GA.10","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.10"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"nsp12":["V128I"]},"labels":{"aa":"nsp12: V128I"}}},{"name":"GA.10.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GA.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.10.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1354C","A1367G","C2592T","T3906C","C6573T","G13822A","A19307G","G22927T","T22928C","A22995G","C25156T","G26828C","C26895T","G26959A","G27561T","C28567T"],"M":["H125Y","R146H"],"ORF9b":["T95M"],"S":["L455F","F456L","K478R"],"nsp12":["V128I"],"nsp14":["K423R"],"nsp2":["I188V","A596V"],"nsp3":["F396S","S1285F"]},"labels":{"aa":"M: H125Y, R146H; ORF9b: T95M; S: L455F, F456L, K478R; nsp12: V128I; nsp14: K423R; nsp2: I188V, A596V; nsp3: F396S, S1285F","spike_mutations":"L455F, F456L, K478R"}}},{"name":"GA.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T6640C","A25927T"],"ORF3a":["I179F"]},"labels":{"aa":"ORF3a: I179F"}}},{"name":"GA.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14024T"],"nsp12":["A195V"]},"labels":{"aa":"nsp12: A195V"}}},{"name":"GA.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"GA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T23797C"]}}},{"name":"GA.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T7534C","G25593T","C29719A"],"ORF3a":["K67N"]},"labels":{"aa":"ORF3a: K67N"}}},{"name":"NODE_0000190","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.2.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T6640C","G23222A","A25927T"],"ORF3a":["I179F"],"S":["E554K"]},"labels":{"aa":"ORF3a: I179F; S: E554K","spike_mutations":"E554K"}},"children":[{"name":"GA.2.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GA.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80721"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C9857T","C10279T","A12235G","A22910G","A22995G","C29002T"],"S":["N450D","K478R"],"nsp1":["M85-"]},"labels":{"aa":"S: N450D, K478R; nsp1: M85-","spike_mutations":"N450D, K478R"}}},{"name":"GA.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000191","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A6677G","G8785A"],"nsp3":["I1320V"]},"labels":{"aa":"nsp3: I1320V"}},"children":[{"name":"GA.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GA.6.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"GA.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","A19767G","C22311T","A22995G","C29642T"],"ORF10":["Q29*"],"S":["T250I","K478R"]},"labels":{"aa":"ORF10: Q29*; S: T250I, K478R","spike_mutations":"T250I, K478R"}}}]},{"name":"NODE_0000192","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3619T","C27389T"]}},"children":[{"name":"GA.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4916G"],"nsp3":["I733V"]},"labels":{"aa":"nsp3: I733V"}}},{"name":"GA.8.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GA.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.96117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A17508G","C19970T","C21721T","A22106G","T23042C","G23222A","C26895T","G28198T"],"M":["H125Y"],"ORF8":["C102F"],"S":["K182E","S494P","E554K"],"nsp15":["A117V"]},"labels":{"aa":"M: H125Y; ORF8: C102F; S: K182E, S494P, E554K; nsp15: A117V","spike_mutations":"K182E, S494P, E554K"}}}]},{"name":"NODE_0000193","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.7"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A2130G","C4551T"],"nsp2":["E442G"],"nsp3":["T611I"]},"labels":{"aa":"nsp2: E442G; nsp3: T611I"}},"children":[{"name":"GA.7","node_attrs":{"div":97,"Nextclade_pango":{"value":"GA.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"GA.7.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"GA.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90647"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C8140T","C9298T","A22005C","A22091-","T22092-","G22093-","G22094-","A22095-","C22096-","C22097-","T22098-","T22099-","G22100-","A22101-","A22102-","G22103-","G22104-","A22105-","A22215G","T23042C","C23123T","T25902A"],"S":["N148T","M177-","D178-","L179-","E180-","G181-","Q218R","S494P","P521S"]},"labels":{"aa":"S: N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S","spike_mutations":"N148T, M177-, D178-, L179-, E180-, G181-, Q218R, S494P, P521S"}}},{"name":"GA.7.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.7.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C22295T"],"S":["H245Y"]},"labels":{"aa":"S: H245Y","spike_mutations":"H245Y"}}}]},{"name":"NODE_0000194","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A3503G","C7923T","A22629C"],"S":["K356T"],"nsp3":["N262D","S1735F"]},"labels":{"aa":"S: K356T; nsp3: N262D, S1735F","spike_mutations":"K356T"}},"children":[{"name":"GA.4.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"GA.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C841T","C9857T","C20404T","G23236T","G24932A","C29095T","T29772A"],"S":["K558N","G1124S"],"nsp15":["P262S"]},"labels":{"aa":"S: K558N, G1124S; nsp15: P262S","spike_mutations":"K558N, G1124S"}}},{"name":"GA.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"GA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000195","node_attrs":{"div":101,"Nextclade_pango":{"value":"GA.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3442C","A28877T","G28878C"]}},"children":[{"name":"GA.4.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GA.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3055C","G8185A","C16887T","G17019T","T22118C","C23315T","G25009A","T26103C"],"S":["F186L","L585F"],"nsp13":["E261D"]},"labels":{"aa":"S: F186L, L585F; nsp13: E261D","spike_mutations":"F186L, L585F"}}},{"name":"NODE_0000196","node_attrs":{"div":108,"Nextclade_pango":{"value":"GA.4.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T5290C","C22295T","A22995G","G23222A","C23673T","A28173G","C28896T"],"N":["A208V"],"ORF8":["K94E"],"S":["H245Y","K478R","E554K","S704L"]},"labels":{"aa":"N: A208V; ORF8: K94E; S: H245Y, K478R, E554K, S704L","spike_mutations":"H245Y, K478R, E554K, S704L"}},"children":[{"name":"GA.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GA.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{}}},{"name":"GA.4.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GA.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"GA.4.1.3","node_attrs":{"div":112,"Nextclade_pango":{"value":"GA.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2462T","G4280A","T20229C","G29383T"],"N":["K370N"],"nsp3":["V521I"]},"labels":{"aa":"N: K370N; nsp3: V521I"}}},{"name":"GA.4.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"GA.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.17.1.4.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C763T","G1820A","C23277T","C25791T","G27238C"],"ORF6":["E13Q"],"S":["T572I"],"nsp2":["G339S"]},"labels":{"aa":"ORF6: E13Q; S: T572I; nsp2: G339S","spike_mutations":"T572I"}}}]}]}]}]}]}]},{"name":"internal_XBB_1_5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7987143993377686}},"branch_attrs":{"mutations":{"nuc":["G1T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","clade":"23A","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7987143993377686}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.5.110","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.110"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.110"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.2336883544921875}},"branch_attrs":{"mutations":{"nuc":["C12651T"],"nsp8":["T187I"]},"labels":{"aa":"nsp8: T187I"}}},{"name":"XBB.1.5.23","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.23"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.156744003295898}},"branch_attrs":{"mutations":{"nuc":["C12924T"],"nsp9":["P80L"]},"labels":{"aa":"nsp9: P80L"}}},{"name":"XBB.1.5.22","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.22"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A4758C","T18126A","C21998A"],"S":["Q146K"],"nsp3":["E680A"]},"labels":{"aa":"S: Q146K; nsp3: E680A","spike_mutations":"Q146K"}}},{"name":"XBB.1.5.45","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.45"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G","C27425T","G28079T"],"ORF7a":["T11I"],"S":["K478R"]},"labels":{"aa":"ORF7a: T11I; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.43","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.43"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.547952175140381}},"branch_attrs":{"mutations":{"nuc":["C18501T"]}}},{"name":"XBB.1.5.57","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.57"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.463161945343018}},"branch_attrs":{"mutations":{"nuc":["A20379G","C28312T"],"ORF9b":["S10F"]},"labels":{"aa":"ORF9b: S10F"}}},{"name":"XBB.1.5.58","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.58"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T772A","C2462T","G18286A","C21998A","C23673T","A27218G"],"ORF6":["D6G"],"S":["Q146K","S704L"],"nsp14":["V83I"]},"labels":{"aa":"ORF6: D6G; S: Q146K, S704L; nsp14: V83I","spike_mutations":"Q146K, S704L"}}},{"name":"XBB.1.5.87","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.87"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.87"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","T5028A","G5162A","C9763T","C20946T","A22995C","C24130T"],"S":["K478T"],"nsp3":["M770K","E815K"]},"labels":{"aa":"S: K478T; nsp3: M770K, E815K","spike_mutations":"K478T"}}},{"name":"internal_397fbecf","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.24"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.874494791030884}},"branch_attrs":{"mutations":{"nuc":["C2710T"]}},"children":[{"name":"GF.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"GF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062406063079834}},"branch_attrs":{"mutations":{"nuc":["C19524T","A23805T"],"S":["E748V"]},"labels":{"aa":"S: E748V","spike_mutations":"E748V"}}},{"name":"XBB.1.5.24","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.24"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.874494791030884}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000199","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-2.2820098400115967}},"branch_attrs":{"mutations":{"nuc":["T17124C"]}},"children":[{"name":"XBB.1.5.10","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.10"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.755892753601074}},"branch_attrs":{"mutations":{"nuc":["C18395T","T22928C"],"S":["F456L"],"nsp14":["A119V"]},"labels":{"aa":"S: F456L; nsp14: A119V","spike_mutations":"F456L"}}},{"name":"XBB.1.5.101","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.101"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.101"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.70775842666626}},"branch_attrs":{"mutations":{"nuc":["C14877T","G27762C"],"ORF7b":["E3Q"]},"labels":{"aa":"ORF7b: E3Q"}}},{"name":"XBB.1.5.104","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.104"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.104"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.086434841156006}},"branch_attrs":{"mutations":{"nuc":["A22472C","C29762T"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.105","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.105"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.105"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["T2698C","C2997T","C5365T","G7684A","T16993C","G19999A","A22474C"],"S":["K304N"],"nsp13":["Y253H"],"nsp15":["V127I"],"nsp3":["S93F"]},"labels":{"aa":"S: K304N; nsp13: Y253H; nsp15: V127I; nsp3: S93F","spike_mutations":"K304N"}}},{"name":"XBB.1.5.109","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.109"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.109"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.839313507080078}},"branch_attrs":{"mutations":{"nuc":["A2225G","C5512T","C17439T","T22928C","A29700G"],"S":["F456L"],"nsp2":["T474A"]},"labels":{"aa":"S: F456L; nsp2: T474A","spike_mutations":"F456L"}}},{"name":"XBB.1.5.12","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.12"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.645435094833374}},"branch_attrs":{"mutations":{"nuc":["C22530T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}},{"name":"XBB.1.5.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.11"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9643361568450928}},"branch_attrs":{"mutations":{"nuc":["G1466A"],"nsp2":["G221S"]},"labels":{"aa":"nsp2: G221S"}}},{"name":"XBB.1.5.18","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.18"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.739724636077881}},"branch_attrs":{"mutations":{"nuc":["T44C","C7164T"],"nsp3":["T1482I"]},"labels":{"aa":"nsp3: T1482I"}}},{"name":"XBB.1.5.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.003551483154297}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22413T"],"S":["K147I","T284I"]},"labels":{"aa":"S: K147I, T284I","spike_mutations":"K147I, T284I"}}},{"name":"XBB.1.5.28","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.28"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8692514896392822}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.26","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.406291484832764}},"branch_attrs":{"mutations":{"nuc":["C920T"]}}},{"name":"XBB.1.5.31","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.31"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8875620365142822}},"branch_attrs":{"mutations":{"nuc":["T24976C"]}}},{"name":"XBB.1.5.29","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41404999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.29"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2506C","C11687T","C17874T","C20402T","C20759T","C22605T"],"S":["A348V"],"nsp15":["S261L"],"nsp16":["A34V"],"nsp6":["L239F"]},"labels":{"aa":"S: A348V; nsp15: S261L; nsp16: A34V; nsp6: L239F","spike_mutations":"A348V"}}},{"name":"XBB.1.5.35","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.35"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062806606292725}},"branch_attrs":{"mutations":{"nuc":["A24495G"],"S":["N978S"]},"labels":{"aa":"S: N978S","spike_mutations":"N978S"}}},{"name":"XBB.1.5.34","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.34"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.282310962677002}},"branch_attrs":{"mutations":{"nuc":["C5526T","G9802A"],"nsp3":["T936I"]},"labels":{"aa":"nsp3: T936I"}}},{"name":"XBB.1.5.33","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.33"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.6427886486053467}},"branch_attrs":{"mutations":{"nuc":["G370A"]}}},{"name":"XBB.1.5.36","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.36"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.249703407287598}},"branch_attrs":{"mutations":{"nuc":["C9442T"]}}},{"name":"XBB.1.5.40","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95377"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.40"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.2360076904296875}},"branch_attrs":{"mutations":{"nuc":["A22995T"],"S":["K478I"]},"labels":{"aa":"S: K478I","spike_mutations":"K478I"}}},{"name":"XBB.1.5.51","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.51"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.949040174484253}},"branch_attrs":{"mutations":{"nuc":["A9291C","C25553T"],"ORF3a":["A54V"],"nsp4":["D246A"]},"labels":{"aa":"ORF3a: A54V; nsp4: D246A"}}},{"name":"XBB.1.5.52","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.52"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.848769187927246}},"branch_attrs":{"mutations":{"nuc":["C3589T"]}}},{"name":"XBB.1.5.54","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.54"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C14358T","C20016T","C29311T"]}}},{"name":"XBB.1.5.59","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.59"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.107088088989258}},"branch_attrs":{"mutations":{"nuc":["T44C","T8729C","T22928C"],"S":["F456L"],"nsp4":["S59P"]},"labels":{"aa":"S: F456L; nsp4: S59P","spike_mutations":"F456L"}}},{"name":"XBB.1.5.62","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.62"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.189932823181152}},"branch_attrs":{"mutations":{"nuc":["C29095T"]}}},{"name":"XBB.1.5.63","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.63"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.754556179046631}},"branch_attrs":{"mutations":{"nuc":["C346T"]}}},{"name":"XBB.1.5.64","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.64"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.171535968780518}},"branch_attrs":{"mutations":{"nuc":["G8137A","C29708T"]}}},{"name":"XBB.1.5.67","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.67"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.776366710662842}},"branch_attrs":{"mutations":{"nuc":["C21691T"]}}},{"name":"XBB.1.5.66","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.66"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.803469181060791}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"nsp2":["G339S"]},"labels":{"aa":"nsp2: G339S"}}},{"name":"XBB.1.5.69","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.69"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.275020122528076}},"branch_attrs":{"mutations":{"nuc":["G9092A","C22513T"],"nsp4":["V180I"]},"labels":{"aa":"nsp4: V180I"}}},{"name":"XBB.1.5.75","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.75"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.359410762786865}},"branch_attrs":{"mutations":{"nuc":["T44C","C3695T"]}}},{"name":"XBB.1.5.79","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.79"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.655872344970703}},"branch_attrs":{"mutations":{"nuc":["A29052T"],"N":["Q260L"]},"labels":{"aa":"N: Q260L"}}},{"name":"XBB.1.5.80","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.80"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.80"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.275026798248291}},"branch_attrs":{"mutations":{"nuc":["A16812G","C21812T"]}}},{"name":"XBB.1.5.82","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.82"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91194"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0449196302129404"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.82"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A2863G","A5935G","A22893G","C25854T","C27323T"],"ORF6":["S41F"],"S":["K444R"]},"labels":{"aa":"ORF6: S41F; S: K444R","spike_mutations":"K444R"}}},{"name":"XBB.1.5.86","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.86"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.079804420471191}},"branch_attrs":{"mutations":{"nuc":["G8867A"],"nsp4":["G105S"]},"labels":{"aa":"nsp4: G105S"}}},{"name":"XBB.1.5.85","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.85"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.85"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["T44C","T6754C","C8293T","C22088T","A22995G","C25693T"],"ORF3a":["L101F"],"S":["L176F","K478R"]},"labels":{"aa":"ORF3a: L101F; S: L176F, K478R","spike_mutations":"L176F, K478R"}}},{"name":"XBB.1.5.97","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.97"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.97"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.438870429992676}},"branch_attrs":{"mutations":{"nuc":["T44C","C7834T","A24383T"],"S":["T941S"]},"labels":{"aa":"S: T941S","spike_mutations":"T941S"}}},{"name":"XBB.1.5.99","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.99"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.99"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.521791934967041}},"branch_attrs":{"mutations":{"nuc":["T3630C","C6627T"],"nsp3":["V304A","T1303I"]},"labels":{"aa":"nsp3: V304A, T1303I"}}},{"name":"XBB.1.5.98","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.98"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.98"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T19158C","G23222A","G27987T"],"ORF8":["V32L"],"S":["E554K"]},"labels":{"aa":"ORF8: V32L; S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000200","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.7"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.663036823272705}},"branch_attrs":{"mutations":{"nuc":["G14209T"],"nsp12":["V257F"]},"labels":{"aa":"nsp12: V257F"}},"children":[{"name":"EM.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.39544677734375}},"branch_attrs":{"mutations":{"nuc":["T44C","G22203T"],"S":["R214L"]},"labels":{"aa":"S: R214L","spike_mutations":"R214L"}}},{"name":"XBB.1.5.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.663036823272705}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000201","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.14"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.362810134887695}},"branch_attrs":{"mutations":{"nuc":["C2695T"]}},"children":[{"name":"EL.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.174376964569092}},"branch_attrs":{"mutations":{"nuc":["C12781T","G23587T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}},{"name":"XBB.1.5.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.14"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.362810134887695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_cb7fd0cc","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.38"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.762918472290039}},"branch_attrs":{"mutations":{"nuc":["C1473T","A23558G"],"S":["I666V"],"nsp2":["T223I"]},"labels":{"aa":"S: I666V; nsp2: T223I","spike_mutations":"I666V"}},"children":[{"name":"GG.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.809896945953369}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.38","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.38"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.762918472290039}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000203","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.015121936798096}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"HA.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.779919624328613}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"nsp4":["G105S"],"nsp6":["M143V"]},"labels":{"aa":"nsp4: G105S; nsp6: M143V"}}},{"name":"XBB.1.5.108","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.108"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.108"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2245T","G18106T","A22474T","C23506T","G28371A","C28657T"],"N":["G30-","-33D"],"ORF9b":["V30M"],"S":["K304N"],"nsp14":["A23S"]},"labels":{"aa":"N: G30-, -33D; ORF9b: V30M; S: K304N; nsp14: A23S","spike_mutations":"K304N"}}}]},{"name":"NODE_0000204","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.923110008239746}},"branch_attrs":{"mutations":{"nuc":["C23280T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"HJ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.943153381347656}},"branch_attrs":{"mutations":{"nuc":["C4543T","G22532A"],"S":["E324K"]},"labels":{"aa":"S: E324K","spike_mutations":"E324K"}}},{"name":"XBB.1.5.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.923110008239746}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000205","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.30"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.120842456817627}},"branch_attrs":{"mutations":{"nuc":["G22604A"],"S":["A348T"]},"labels":{"aa":"S: A348T","spike_mutations":"A348T"}},"children":[{"name":"HM.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29094"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1023732112409157"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11824T","C17010T","T23005A","C24358A","G25437T","T27614C"],"ORF3a":["L15F"],"ORF7a":["V74A"],"S":["N481K"]},"labels":{"aa":"ORF3a: L15F; ORF7a: V74A; S: N481K","spike_mutations":"N481K"}}},{"name":"XBB.1.5.30","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41123000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.30"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.120842456817627}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_22395f88","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.92"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.741388320922852}},"branch_attrs":{"mutations":{"nuc":["T44C","C3768T"],"nsp3":["T350I"]},"labels":{"aa":"nsp3: T350I"}},"children":[{"name":"HQ.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"HQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C823T","C10615T","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.92","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.92"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.92"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.741388320922852}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_1846b094","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.100"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.495574951171875}},"branch_attrs":{"mutations":{"nuc":["G24926A"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}},"children":[{"name":"HY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"HY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.282982349395752}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.100","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.100"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.100"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.495574951171875}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_884dc5b8","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.3"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7761480808258057}},"branch_attrs":{"mutations":{"nuc":["G22793T"],"S":["A411S"]},"labels":{"aa":"S: A411S","spike_mutations":"A411S"}},"children":[{"name":"JK.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"JK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.8508501052856445}},"branch_attrs":{"mutations":{"nuc":["A22472C","T28665G"],"N":["I131R"],"S":["K304Q"]},"labels":{"aa":"N: I131R; S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.5.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7761480808258057}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_149f3d85","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.107"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.523141384124756}},"branch_attrs":{"mutations":{"nuc":["C24130T"]}},"children":[{"name":"JZ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"JZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.971319675445557}},"branch_attrs":{"mutations":{"nuc":["C18508T","T22928C"],"S":["F456L"],"nsp14":["L157F"]},"labels":{"aa":"S: F456L; nsp14: L157F","spike_mutations":"F456L"}}},{"name":"XBB.1.5.107","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.107"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.107"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.523141384124756}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_28e6a1f7","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.4"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9941704273223877}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"KM.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"KM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10138T","A11351G","G22093C","A22115G","A22995G","G25507A","C28132T","C28737T"],"N":["A155V"],"ORF3a":["A39T"],"ORF8":["T80I"],"S":["M177I","N185D","K478R"],"nsp6":["T127A"]},"labels":{"aa":"N: A155V; ORF3a: A39T; ORF8: T80I; S: M177I, N185D, K478R; nsp6: T127A","spike_mutations":"M177I, N185D, K478R"}}},{"name":"XBB.1.5.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.9941704273223877}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_101d8393","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.398263931274414}},"branch_attrs":{"mutations":{"nuc":["C20178T"]}},"children":[{"name":"XBB.1.5.50","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.50"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6555T","C23423T","C28419T","T28945C"],"N":["T49I"],"S":["P621S"],"nsp3":["A1279V"]},"labels":{"aa":"N: T49I; S: P621S; nsp3: A1279V","spike_mutations":"P621S"}}},{"name":"XBB.1.5.71","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48403999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.71"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.380550861358643}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C21691T","G23093A"],"S":["V511I"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"S: V511I; nsp1: G82-, H83-, V84-, M85V","spike_mutations":"V511I"}}}]},{"name":"NODE_0000212","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.21"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.277703762054443}},"branch_attrs":{"mutations":{"nuc":["A1230G","C22945T"],"nsp2":["K142R"]},"labels":{"aa":"nsp2: K142R"}},"children":[{"name":"GC.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"GC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9061"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.03073601411565"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.990260601043701}},"branch_attrs":{"mutations":{"nuc":["G22616T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}},{"name":"GC.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T13291G","C20178T","C22530T","T23137C","G29554A"],"S":["T323I"],"nsp10":["F89L"]},"labels":{"aa":"S: T323I; nsp10: F89L","spike_mutations":"T323I"}}},{"name":"XBB.1.5.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.21"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.277703762054443}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000213","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.93"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.037090301513672}},"branch_attrs":{"mutations":{"nuc":["C337T","C19186T"]}},"children":[{"name":"XBB.1.5.93","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.93"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.037090301513672}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000214","node_attrs":{"div":103,"Nextclade_pango":{"value":"HD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T44C","T2308C","C7104A","A7483G","C15951T","T18510A","C22599T","C26807T"],"S":["T346I"],"nsp3":["T1462N"]},"labels":{"aa":"S: T346I; nsp3: T1462N","spike_mutations":"T346I"}},"children":[{"name":"HD.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7416800000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HD.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.73864"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.93.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}}]}]},{"name":"internal_bb14c08e","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.55"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.264838695526123}},"branch_attrs":{"mutations":{"nuc":["C10332T"],"nsp5":["T93I"]},"labels":{"aa":"nsp5: T93I"}},"children":[{"name":"XBB.1.5.55","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.264838695526123}},"branch_attrs":{"mutations":{}}},{"name":"internal_479ab5c8","node_attrs":{"div":96,"Nextclade_pango":{"value":"HP.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C28310T","C29095T"],"N":["L13F"]},"labels":{"aa":"N: L13F"}},"children":[{"name":"HP.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"HP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"HP.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"HP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.55.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"internal_7190b9dc","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.95"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.288678169250488}},"branch_attrs":{"mutations":{"nuc":["C5817T"],"nsp3":["A1033V"]},"labels":{"aa":"nsp3: A1033V"}},"children":[{"name":"XBB.1.5.95","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.95"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.288678169250488}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000218","node_attrs":{"div":95,"Nextclade_pango":{"value":"HS.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"HS.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"HS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.832055568695068}},"branch_attrs":{"mutations":{}}},{"name":"HS.1.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.95.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.999259948730469}},"branch_attrs":{"mutations":{"nuc":["C6628T","T10084A","C10252T","T22928C","G28077T"],"ORF8":["V62L"],"S":["F456L"]},"labels":{"aa":"ORF8: V62L; S: F456L","spike_mutations":"F456L"}}}]}]},{"name":"internal_e17e","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.16"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.016602993011475}},"branch_attrs":{"mutations":{"nuc":["T14766C"]}},"children":[{"name":"FG.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1186099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1190T","C22413T","G22770A","C23099T","A24430C","C25484T","C26198T"],"ORF3a":["A31V","T269M"],"S":["T284I","R403K","L513F"],"nsp2":["P129S"]},"labels":{"aa":"ORF3a: A31V, T269M; S: T284I, R403K, L513F; nsp2: P129S","spike_mutations":"T284I, R403K, L513F"}}},{"name":"FG.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.693484306335449}},"branch_attrs":{"mutations":{"nuc":["T44C","A24362G"],"S":["I934V"]},"labels":{"aa":"S: I934V","spike_mutations":"I934V"}}},{"name":"FG.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.512086391448975}},"branch_attrs":{"mutations":{"nuc":["G22094A"],"S":["D178N"]},"labels":{"aa":"S: D178N","spike_mutations":"D178N"}}},{"name":"XBB.1.5.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.16"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.016602993011475}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000220","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.47"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.372424125671387}},"branch_attrs":{"mutations":{"nuc":["T44C","C1912T"]}},"children":[{"name":"FZ.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T11377A","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}},{"name":"XBB.1.5.47","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.372424125671387}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000221","node_attrs":{"div":96,"Nextclade_pango":{"value":"FZ.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}},"children":[{"name":"FZ.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A24005C","G24007T","C24134A","A24922G","G25972A"],"ORF3a":["E194K"],"S":["L858I"]},"labels":{"aa":"ORF3a: E194K; S: L858I","spike_mutations":"L858I"}}},{"name":"FZ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.47.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000222","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C18501T","C23123A","C25603A"],"ORF3a":["L71I"],"S":["P521T"]},"labels":{"aa":"ORF3a: L71I; S: P521T","spike_mutations":"P521T"}},"children":[{"name":"HZ.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"HZ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["T11343C"],"nsp6":["I124T"]},"labels":{"aa":"nsp6: I124T"}}},{"name":"XBB.1.5.68","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000223","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.68"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T10721C"],"nsp5":["F223L"]},"labels":{"aa":"nsp5: F223L"}},"children":[{"name":"HZ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"HZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C23266T","A28108T"],"ORF8":["Q72L"],"S":["K478R"]},"labels":{"aa":"ORF8: Q72L; S: K478R","spike_mutations":"K478R"}}},{"name":"HZ.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"HZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.68.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C11003T"],"nsp6":["H11Y"]},"labels":{"aa":"nsp6: H11Y"}}}]}]},{"name":"NODE_0000224","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{"nuc":["C1288T","C16332T","C16989T","C19263T","A22629C","C23277T","C25667T"],"ORF3a":["S92L"],"S":["K356T","T572I"]},"labels":{"aa":"ORF3a: S92L; S: K356T, T572I","spike_mutations":"K356T, T572I"}},"children":[{"name":"HC.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"HC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C5849T","A11588G","A21999C","C23453T"],"S":["Q146P","P631S"],"nsp3":["P1044S"],"nsp6":["T206A"]},"labels":{"aa":"S: Q146P, P631S; nsp3: P1044S; nsp6: T206A","spike_mutations":"Q146P, P631S"}}},{"name":"XBB.1.5.44","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.8757429122924805}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000225","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.5.44"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3483T"],"nsp3":["G255V"]},"labels":{"aa":"nsp3: G255V"}},"children":[{"name":"HC.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"HC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A1540G","C4331T","C10252T","C11095T","C22033A","A28699T"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HC.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"HC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A10399G","C19983T","C23939T","C27881T"],"S":["P793S"]},"labels":{"aa":"S: P793S","spike_mutations":"P793S"}}},{"name":"HC.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"HC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.44.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4320T","G5837A","C13297T","T14040C","G24812C","T26112C"],"S":["D1084H"],"nsp3":["A534V","E1040K"]},"labels":{"aa":"S: D1084H; nsp3: A534V, E1040K","spike_mutations":"D1084H"}}}]}]},{"name":"NODE_0000226","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.13"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.5769400596618652}},"branch_attrs":{"mutations":{"nuc":["T21880C","G28079T"]}},"children":[{"name":"EK.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9873000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0346353162114479"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C16173T","A22812G","C26936A","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N417S"],"nsp1":["M85-"]},"labels":{"aa":"S: N417S; nsp1: M85-","spike_mutations":"N417S"}}},{"name":"EK.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"EK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.174642086029053}},"branch_attrs":{"mutations":{"nuc":["C23585A"],"S":["Q675K"]},"labels":{"aa":"S: Q675K","spike_mutations":"Q675K"}}},{"name":"EK.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A20118G","C22313T","A29844G"],"S":["P251S"]},"labels":{"aa":"S: P251S","spike_mutations":"P251S"}}},{"name":"XBB.1.5.13","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.5769400596618652}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000227","node_attrs":{"div":99,"Nextclade_pango":{"value":"EK.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C715T","C11750T","T16539C","C22338T"],"S":["T259I"],"nsp6":["L260F"]},"labels":{"aa":"S: T259I; nsp6: L260F","spike_mutations":"T259I"}},"children":[{"name":"EK.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{}}},{"name":"EK.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"EK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.13.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["T44C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000228","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.045679092407227}},"branch_attrs":{"mutations":{"nuc":["C23123T"],"S":["P521S"]},"labels":{"aa":"S: P521S","spike_mutations":"P521S"}},"children":[{"name":"HA.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"HA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.86.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["G8867A","A11399G"],"nsp4":["G105S"],"nsp6":["M143V"]},"labels":{"aa":"nsp4: G105S; nsp6: M143V"}}},{"name":"NODE_0000229","node_attrs":{"div":96,"Nextclade_pango":{"value":"EU.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{"nuc":["C920T","C21910A"]}},"children":[{"name":"EU.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9577000000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.085105895996094}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000230","node_attrs":{"div":98,"Nextclade_pango":{"value":"EU.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{"nuc":["T44C","A22790G"],"S":["I410V"]},"labels":{"aa":"S: I410V","spike_mutations":"I410V"}},"children":[{"name":"EU.1.1.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EU.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G24770T"],"S":["A1070S"]},"labels":{"aa":"S: A1070S","spike_mutations":"A1070S"}}},{"name":"EU.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.314939975738525}},"branch_attrs":{"mutations":{}}},{"name":"EU.1.1.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EU.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C22033A","C28045T"],"ORF8":["A51V"],"S":["F157L"]},"labels":{"aa":"ORF8: A51V; S: F157L","spike_mutations":"F157L"}}},{"name":"EU.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EU.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5237400000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9548847118984406"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.26.1.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.334163188934326}},"branch_attrs":{"mutations":{"nuc":["C21646T"]}}}]}]}]},{"name":"NODE_0000231","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.344803810119629}},"branch_attrs":{"mutations":{"nuc":["T44C","T28271C"]}},"children":[{"name":"GN.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"GN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.837703704833984}},"branch_attrs":{"mutations":{"nuc":["C27143T"]}}},{"name":"GN.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"GN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C3593A","C12669T"],"nsp3":["L292I"],"nsp8":["S193F"]},"labels":{"aa":"nsp3: L292I; nsp8: S193F"}}},{"name":"GN.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"GN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12162T"],"nsp8":["Q24L"]},"labels":{"aa":"nsp8: Q24L"}}},{"name":"XBB.1.5.73","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.344803810119629}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000232","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.73"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.668724536895752}},"branch_attrs":{"mutations":{"nuc":["C7834T","C10332T","G25445T"],"ORF3a":["G18V"],"nsp5":["T93I"]},"labels":{"aa":"ORF3a: G18V; nsp5: T93I"}},"children":[{"name":"GN.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C25688G"],"ORF3a":["A99G"]},"labels":{"aa":"ORF3a: A99G"}}},{"name":"NODE_0000233","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.348021030426025}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"GN.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.348021030426025}},"branch_attrs":{"mutations":{}}},{"name":"GN.1.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"GN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6286T","A22524T","C27524T"],"ORF7a":["S44L"],"S":["Q321L"]},"labels":{"aa":"ORF7a: S44L; S: Q321L","spike_mutations":"Q321L"}}},{"name":"GN.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.514015197753906}},"branch_attrs":{"mutations":{"nuc":["C92T","C18395T"],"nsp14":["A119V"]},"labels":{"aa":"nsp14: A119V"}}},{"name":"GN.1.4","node_attrs":{"div":104,"Nextclade_pango":{"value":"GN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2548C","T16866C","T18990C","T21799C","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"GN.1.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.73.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12896A","C17163T","C20115T","G22927T","A23971T","T29760C"],"S":["L455F"],"nsp9":["P71T"]},"labels":{"aa":"S: L455F; nsp9: P71T","spike_mutations":"L455F"}}}]}]}]},{"name":"internal_81e030d7","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.102"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.852011203765869}},"branch_attrs":{"mutations":{"nuc":["T44C","C6896T","C14085T","C19488T"]}},"children":[{"name":"XBB.1.5.102","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.102"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.852011203765869}},"branch_attrs":{"mutations":{}}},{"name":"internal_854db48f","node_attrs":{"div":99,"Nextclade_pango":{"value":"JD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{"nuc":["G4255A","C20629T"],"nsp15":["H337Y"]},"labels":{"aa":"nsp15: H337Y"}},"children":[{"name":"JD.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"JD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.425548553466797}},"branch_attrs":{"mutations":{}}},{"name":"JD.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C14178T","T22510C","G23222A","C27513T"],"S":["E554K"],"nsp2":["G339S"]},"labels":{"aa":"S: E554K; nsp2: G339S","spike_mutations":"E554K"}}}]},{"name":"internal_f85df148","node_attrs":{"div":101,"Nextclade_pango":{"value":"JD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.622837066650391}},"branch_attrs":{"mutations":{"nuc":["A14634G","G22927T","T22928C","T28282C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"JD.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"JD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.622837066650391}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000237","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19182G","C25046T","C29762T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}},"children":[{"name":"JD.1.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JD.1.2.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"JD.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T6136C","C13968T","C15951T","C16887T","T18435G","G23222C","C28087T","C28657T","C29367T"],"N":["P365L"],"ORF8":["A65V"],"S":["E554Q"],"nsp14":["D132E"]},"labels":{"aa":"N: P365L; ORF8: A65V; S: E554Q; nsp14: D132E","spike_mutations":"E554Q"}}},{"name":"JD.1.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.2.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C925T","T15309C","G24794A"],"S":["A1078T"]},"labels":{"aa":"S: A1078T","spike_mutations":"A1078T"}}}]},{"name":"internal_e98e0790","node_attrs":{"div":103,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.970474720001221}},"branch_attrs":{"mutations":{"nuc":["C14189T","C22986T"],"S":["A475V"],"nsp12":["A250V"]},"labels":{"aa":"S: A475V; nsp12: A250V","spike_mutations":"A475V"}},"children":[{"name":"JD.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.970474720001221}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000239","node_attrs":{"div":104,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.197541236877441}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"NODE_0000240","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.8"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["T3547A","A3706T"],"nsp3":["N276K"]},"labels":{"aa":"nsp3: N276K"}},"children":[{"name":"JD.1.1.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{}}},{"name":"KK.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"KK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["A6084G","G25019C"],"S":["D1153H"],"nsp3":["D1122G"]},"labels":{"aa":"S: D1153H; nsp3: D1122G","spike_mutations":"D1153H"}}},{"name":"KK.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"KK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.20635"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2868306565498102"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.8.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"NODE_0000241","node_attrs":{"div":105,"Nextclade_pango":{"value":"JD.1.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.3283803462982178}},"branch_attrs":{"mutations":{"nuc":["C19185T"]}},"children":[{"name":"JD.1.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A1051G","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"JD.1.1.4","node_attrs":{"div":110,"Nextclade_pango":{"value":"JD.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T5303C","A23223G","C27849T","C29245T","C29281T"],"ORF7b":["L32F"],"S":["E554G"]},"labels":{"aa":"ORF7b: L32F; S: E554G","spike_mutations":"E554G"}}},{"name":"JD.1.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7317914962768555}},"branch_attrs":{"mutations":{"nuc":["C44T","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"JD.1.1.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"JD.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1261900000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3046787170970133"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["G5015A","C22971A","A27283G"],"ORF6":["N28D"],"S":["T470N"],"nsp3":["V766M"]},"labels":{"aa":"ORF6: N28D; S: T470N; nsp3: V766M","spike_mutations":"T470N"}}},{"name":"JD.1.1.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"JD.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.6"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["T17599C","A22019G"],"S":["M153V"]},"labels":{"aa":"S: M153V","spike_mutations":"M153V"}}},{"name":"JD.1.1.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"JD.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.7"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G20238T"],"nsp15":["R206S"]},"labels":{"aa":"nsp15: R206S"}}},{"name":"JD.1.1.5","node_attrs":{"div":110,"Nextclade_pango":{"value":"JD.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.102.1.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C1102T","A5608G","C15579T","A23592G"],"S":["Q677R"]},"labels":{"aa":"S: Q677R","spike_mutations":"Q677R"}}}]}]}]}]}]},{"name":"NODE_0000242","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["C1973T","C7564T","T8737C","G12467T","C22624T","G22927T","T22928C","A25045G","C27059T","C28005T"],"ORF8":["P38S"],"S":["L455F","F456L"],"nsp8":["A126S"]},"labels":{"aa":"ORF8: P38S; S: L455F, F456L; nsp8: A126S","clade":"23G","spike_mutations":"L455F, F456L"}},"children":[{"name":"GK.10","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A16550G","A23223G","C27131T"],"S":["E554G"],"nsp13":["D105G"]},"labels":{"aa":"S: E554G; nsp13: D105G","spike_mutations":"E554G"}}},{"name":"GK.11","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"GK.6","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A20304G","C21998A","C23230A","A23310C","G29440A"],"S":["Q146K","N556K","E583A"]},"labels":{"aa":"S: Q146K, N556K, E583A","spike_mutations":"Q146K, N556K, E583A"}}},{"name":"GK.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.7"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A28281G"],"N":["D3G"]},"labels":{"aa":"N: D3G"}}},{"name":"GK.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.9"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22482G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}},{"name":"XBB.1.5.70","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.5.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000243","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.5"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7732T","G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"GK.5.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15842T","G22100A"],"S":["E180K"],"nsp12":["T801I"]},"labels":{"aa":"S: E180K; nsp12: T801I","spike_mutations":"E180K"}}},{"name":"GK.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e63e1170","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G27364C"],"ORF6":["E55Q"]},"labels":{"aa":"ORF6: E55Q"}},"children":[{"name":"GK.8.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A4929G","A6293G","C13019T","A22116T","C22986T"],"S":["N185I","A475V"],"nsp3":["N737S","I1192V"]},"labels":{"aa":"S: N185I, A475V; nsp3: N737S, I1192V","spike_mutations":"N185I, A475V"}}},{"name":"GK.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"GK.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_ce4eb31f","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12469T"]}},"children":[{"name":"GK.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8841T","C14396T","C18807T","C22986T"],"S":["A475V"],"nsp12":["T319I"],"nsp4":["T96I"]},"labels":{"aa":"S: A475V; nsp12: T319I; nsp4: T96I","spike_mutations":"A475V"}}},{"name":"internal_62a451c3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.3"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["G2891T"],"nsp3":["A58S"]},"labels":{"aa":"nsp3: A58S"}},"children":[{"name":"GK.3.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"GK.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{}}},{"name":"GK.3.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.3.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C4189T","C21306T","C23277T","C26801T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]},{"name":"NODE_0000247","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.5.70"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23741T"]}},"children":[{"name":"GK.12","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.4253100000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.12"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G8393A","G9652T","C9665T","C21789T","A22910G"],"S":["T76I","N450D"],"nsp3":["A1892T"],"nsp4":["M366I","P371S"]},"labels":{"aa":"S: T76I, N450D; nsp3: A1892T; nsp4: M366I, P371S","spike_mutations":"T76I, N450D"}}},{"name":"NODE_0000248","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{"nuc":["T2824C","G23093A"],"S":["V511I"]},"labels":{"aa":"S: V511I","spike_mutations":"V511I"}},"children":[{"name":"GK.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23224T"],"S":["E554D"]},"labels":{"aa":"S: E554D","spike_mutations":"E554D"}}},{"name":"GK.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.521153926849365}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.4","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.8981300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T10204C","C21781T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"GK.2.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.8981300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4069020708463185"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G16236A","A22629C","C29870A"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"internal_5681d944","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{"nuc":["C2135A","T11187C","C15755G"],"nsp12":["S772C"],"nsp2":["L444I"],"nsp6":["L72S"]},"labels":{"aa":"nsp12: S772C; nsp2: L444I; nsp6: L72S"}},"children":[{"name":"GK.2.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.28887414932251}},"branch_attrs":{"mutations":{}}},{"name":"GK.2.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.89509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.2.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G463A","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}}]}]}]},{"name":"NODE_0000250","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25658T","C28657T"],"ORF3a":["T89I"],"S":["S704L"]},"labels":{"aa":"ORF3a: T89I; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"GK.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"GK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.3"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1124G","A2163C","A16856G"],"nsp13":["D207G"],"nsp2":["R107G","E453A"]},"labels":{"aa":"nsp13: D207G; nsp2: R107G, E453A"}}},{"name":"GK.1.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.4"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C7401T","C21855T","A22995G"],"S":["S98F","K478R"],"nsp3":["A1561V"]},"labels":{"aa":"S: S98F, K478R; nsp3: A1561V","spike_mutations":"S98F, K478R"}}},{"name":"GK.1.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.5"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C5055T","C22120A"],"S":["F186L"],"nsp3":["T779I"]},"labels":{"aa":"S: F186L; nsp3: T779I","spike_mutations":"F186L"}}},{"name":"GK.1.7","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.7"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T11695C","C22120A"],"S":["F186L"]},"labels":{"aa":"S: F186L","spike_mutations":"F186L"}}},{"name":"GK.1.9","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.9"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C17010T"]}}},{"name":"internal_a28bdb05","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{"nuc":["C23280T","C26735T"],"S":["T573I"]},"labels":{"aa":"S: T573I","spike_mutations":"T573I"}},"children":[{"name":"GK.1.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"GK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.093986988067627}},"branch_attrs":{"mutations":{"nuc":["C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}}},{"name":"GK.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-3.7136266231536865}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a6b5bb0b","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.2"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"GK.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"GK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.2.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"GK.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.2.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A705G","C4586T","C4810G","G8039T","G8408A","C12789T","C17718T","C17745A","C18693A","T21802C","C22986T"],"S":["A475V"],"nsp1":["D147G"],"nsp13":["N503K"],"nsp3":["D1774Y","V1897I"],"nsp9":["T35I"]},"labels":{"aa":"S: A475V; nsp1: D147G; nsp13: N503K; nsp3: D1774Y, V1897I; nsp9: T35I","spike_mutations":"A475V"}}}]},{"name":"internal_d742ba8f","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.1.11"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1191T","T3766C","C22986T","A25725G"],"S":["A475V"],"nsp2":["P129L"]},"labels":{"aa":"S: A475V; nsp2: P129L","spike_mutations":"A475V"}},"children":[{"name":"GK.1.11","node_attrs":{"div":110,"Nextclade_pango":{"value":"GK.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.11.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.11.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A7385C","G18832A","A21764G"],"S":["I68V"],"nsp14":["G265S"],"nsp3":["M1556L"]},"labels":{"aa":"S: I68V; nsp14: G265S; nsp3: M1556L","spike_mutations":"I68V"}}}]},{"name":"internal_3eae3f29","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.6"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C853T","G25540A"],"ORF3a":["V50I"]},"labels":{"aa":"ORF3a: V50I"}},"children":[{"name":"GK.1.6.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A605G","C22564T","C22986T"],"S":["A475V"],"nsp1":["I114V"]},"labels":{"aa":"S: A475V; nsp1: I114V","spike_mutations":"A475V"}}},{"name":"GK.1.6","node_attrs":{"div":108,"Nextclade_pango":{"value":"GK.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.6"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_34743931","node_attrs":{"div":114,"Nextclade_pango":{"value":"GK.1.8"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C311T","A5608G","G6884A","C6906T","C18120T","C22986T","G23222A","T25370C"],"S":["A475V","E554K"],"nsp1":["L16F"],"nsp3":["G1389S","S1396L"]},"labels":{"aa":"S: A475V, E554K; nsp1: L16F; nsp3: G1389S, S1396L","spike_mutations":"A475V, E554K"}},"children":[{"name":"GK.1.8","node_attrs":{"div":114,"Nextclade_pango":{"value":"GK.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"GK.1.8.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"GK.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.8.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6401T","T20733C","A22122T","G22226C","G25793A"],"ORF3a":["R134H"],"S":["K187I","A222P"],"nsp3":["P1228S"]},"labels":{"aa":"ORF3a: R134H; S: K187I, A222P; nsp3: P1228S","spike_mutations":"K187I, A222P"}}}]},{"name":"NODE_0000256","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.10"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A1982G","T8167C","C12651T","C28087T","C28567T"],"ORF8":["A65V"],"ORF9b":["T95M"],"nsp2":["I393V"],"nsp8":["T187I"]},"labels":{"aa":"ORF8: A65V; ORF9b: T95M; nsp2: I393V; nsp8: T187I"}},"children":[{"name":"GK.1.10","node_attrs":{"div":111,"Nextclade_pango":{"value":"GK.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000257","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.10.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C22986T","C29668T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}},"children":[{"name":"GK.1.10.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"GK.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000258","node_attrs":{"div":114,"Nextclade_pango":{"value":"KN.1"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"KN.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"KN.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"KN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.1446400000000003"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3541583181563797"},"clade_display":{"value":"23G (XBB.1.5.70)"},"partiallyAliased":{"value":"XBB.1.5.70.1.10.1.1.1"},"clade_nextstrain":{"value":"23G"},"clade_membership":{"value":"23G"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C5526T","C21575T","A22910G"],"S":["L5F","N450D"],"nsp3":["T936I"]},"labels":{"aa":"S: L5F, N450D; nsp3: T936I","spike_mutations":"L5F, N450D"}}}]}]}]}]}]},{"name":"NODE_0000259","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-2.4134323596954346}},"branch_attrs":{"mutations":{"nuc":["T10204C"]}},"children":[{"name":"XBB.1.5.106","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.106"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.106"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.2054524421691895}},"branch_attrs":{"mutations":{"nuc":["T44C","G347A","G10890A","C23430T"],"S":["A623V"],"nsp1":["V28I"],"nsp5":["R279H"]},"labels":{"aa":"S: A623V; nsp1: V28I; nsp5: R279H","spike_mutations":"A623V"}}},{"name":"XBB.1.5.20","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.20"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.6762609481811523}},"branch_attrs":{"mutations":{"nuc":["C9532T"]}}},{"name":"XBB.1.5.19","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.19"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.062256813049316}},"branch_attrs":{"mutations":{"nuc":["C13981T"],"nsp12":["R181C"]},"labels":{"aa":"nsp12: R181C"}}},{"name":"XBB.1.5.25","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.25"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.187304496765137}},"branch_attrs":{"mutations":{"nuc":["T44C","A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}},{"name":"XBB.1.5.27","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.27"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.515915393829346}},"branch_attrs":{"mutations":{"nuc":["A3309G","T11431C","A22995G"],"S":["K478R"],"nsp3":["E197G"]},"labels":{"aa":"S: K478R; nsp3: E197G","spike_mutations":"K478R"}}},{"name":"XBB.1.5.32","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.32"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.674532651901245}},"branch_attrs":{"mutations":{"nuc":["C8733T"],"nsp4":["T60I"]},"labels":{"aa":"nsp4: T60I"}}},{"name":"XBB.1.5.37","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.37"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.537872552871704}},"branch_attrs":{"mutations":{"nuc":["A24696G"],"S":["K1045R"]},"labels":{"aa":"S: K1045R","spike_mutations":"K1045R"}}},{"name":"XBB.1.5.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.0984392166137695}},"branch_attrs":{"mutations":{"nuc":["C7002T","A25104T"],"S":["K1181I"],"nsp3":["S1428L"]},"labels":{"aa":"S: K1181I; nsp3: S1428L","spike_mutations":"K1181I"}}},{"name":"XBB.1.5.56","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.56"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.201124668121338}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"XBB.1.5.60","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.60"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.624990940093994}},"branch_attrs":{"mutations":{"nuc":["C6582T","G22093T"],"S":["M177I"],"nsp3":["T1288I"]},"labels":{"aa":"S: M177I; nsp3: T1288I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.6"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.539541721343994}},"branch_attrs":{"mutations":{"nuc":["G24416A"],"S":["V952I"]},"labels":{"aa":"S: V952I","spike_mutations":"V952I"}}},{"name":"XBB.1.5.61","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.61"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.265592575073242}},"branch_attrs":{"mutations":{"nuc":["T11536C","C16887T"]}}},{"name":"XBB.1.5.65","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.65"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.8307547569274902}},"branch_attrs":{"mutations":{"nuc":["C583T"]}}},{"name":"XBB.1.5.74","node_attrs":{"div":100,"Nextclade_pango":{"value":"XBB.1.5.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9630099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0169257119491577"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.74"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C835T","C4391A","G15649A","A22947G","C27925T"],"ORF8":["T11I"],"S":["K462R"],"nsp12":["V737I"]},"labels":{"aa":"ORF8: T11I; S: K462R; nsp12: V737I","spike_mutations":"K462R"}}},{"name":"XBB.1.5.72","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.72"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.7908687591552734}},"branch_attrs":{"mutations":{"nuc":["G1598A","T9823C","T22928C","C25728T"],"S":["F456L"],"nsp2":["G265S"]},"labels":{"aa":"S: F456L; nsp2: G265S","spike_mutations":"F456L"}}},{"name":"XBB.1.5.76","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.76"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.102578639984131}},"branch_attrs":{"mutations":{"nuc":["T44C","A11351G"],"nsp6":["T127A"]},"labels":{"aa":"nsp6: T127A"}}},{"name":"XBB.1.5.78","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.78"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.389560222625732}},"branch_attrs":{"mutations":{"nuc":["A1643G"],"nsp2":["N280D"]},"labels":{"aa":"nsp2: N280D"}}},{"name":"XBB.1.5.81","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.81"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.81"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.628523826599121}},"branch_attrs":{"mutations":{"nuc":["G4657A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.8"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.449106693267822}},"branch_attrs":{"mutations":{"nuc":["G28302A"],"N":["R10Q"],"ORF9b":["E7K"]},"labels":{"aa":"N: R10Q; ORF9b: E7K"}}},{"name":"XBB.1.5.83","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.83"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.83"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.545587539672852}},"branch_attrs":{"mutations":{"nuc":["T44C","A10624G"]}}},{"name":"XBB.1.5.84","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.84"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.84"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.249866485595703}},"branch_attrs":{"mutations":{"nuc":["G22093A"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"XBB.1.5.89","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.5.89"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.89"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G8872T","A22995G","A23223C","C27752T"],"ORF7a":["T120I"],"S":["K478R","E554A"],"nsp4":["L106F"]},"labels":{"aa":"ORF7a: T120I; S: K478R, E554A; nsp4: L106F","spike_mutations":"K478R, E554A"}}},{"name":"XBB.1.5.88","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.88"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.88"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.301758766174316}},"branch_attrs":{"mutations":{"nuc":["C2299T"]}}},{"name":"XBB.1.5.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.9"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.153419494628906}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}}},{"name":"XBB.1.5.91","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.91"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.91"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.224374771118164}},"branch_attrs":{"mutations":{"nuc":["C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"XBB.1.5.90","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.90"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.90"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C10615T","T19284C","C20402T","C23423T","C25324T"],"S":["P621S"],"nsp15":["S261L"]},"labels":{"aa":"S: P621S; nsp15: S261L","spike_mutations":"P621S"}}},{"name":"XBB.1.5.94","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.94"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.94"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.447930335998535}},"branch_attrs":{"mutations":{"nuc":["G23401T","T25461C"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.5.96","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.96"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.96"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.111927032470703}},"branch_attrs":{"mutations":{"nuc":["C28603T"]}}},{"name":"NODE_0000260","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.5"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29580T"],"ORF10":["A8V"]},"labels":{"aa":"ORF10: A8V"}},"children":[{"name":"FD.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.038019180297852}},"branch_attrs":{"mutations":{}}},{"name":"FD.5.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.5.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["T44C","C17304T","A22115G","T22928C"],"S":["N185D","F456L"]},"labels":{"aa":"S: N185D, F456L","spike_mutations":"N185D, F456L"}}}]},{"name":"NODE_0000261","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.17"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.786716938018799}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FH.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.485838413238525}},"branch_attrs":{"mutations":{"nuc":["C4633T","C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"XBB.1.5.17","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.17"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.786716938018799}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000262","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.42"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{"nuc":["A22405T","C29095T","C29870A"],"S":["E281D"]},"labels":{"aa":"S: E281D","spike_mutations":"E281D"}},"children":[{"name":"GR.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.83085"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.065552234649658}},"branch_attrs":{"mutations":{"nuc":["C22895T"],"S":["P445S"]},"labels":{"aa":"S: P445S","spike_mutations":"P445S"}}},{"name":"XBB.1.5.42","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.5.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.42"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.072257041931152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000263","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.41"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8818T","C10036T","G18583A","C23123A","G23876A"],"S":["P521T","V772I"],"nsp14":["V182I"]},"labels":{"aa":"S: P521T, V772I; nsp14: V182I","spike_mutations":"P521T, V772I"}},"children":[{"name":"GU.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.83156"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9838451476656441"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T16203C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}},{"name":"XBB.1.5.41","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93473"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9544161880958891"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.41"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_56c7461f","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.48"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.185719013214111}},"branch_attrs":{"mutations":{"nuc":["A24730T"]}},"children":[{"name":"GV.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"GV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.135186195373535}},"branch_attrs":{"mutations":{"nuc":["A22995G","T27810C"],"ORF7b":["F19L"],"S":["K478R"]},"labels":{"aa":"ORF7b: F19L; S: K478R","spike_mutations":"K478R"}}},{"name":"XBB.1.5.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.48"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.185719013214111}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000265","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.103"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.166083812713623}},"branch_attrs":{"mutations":{"nuc":["T44C","C4575T","T21357C","A22101-","A22102-","G22103-","G22104-","A22105-","A22106-","A22107-","A22108-","G22109-","A22110-","G22111-","G22112-","G22113-","T22114-","A22115-","T22928C","T27878G"],"ORF7b":["C41W"],"S":["E180-","G181-","K182-","E183-","G184-","N185D","F456L"],"nsp3":["T619I"]},"labels":{"aa":"ORF7b: C41W; S: E180-, G181-, K182-, E183-, G184-, N185D, F456L; nsp3: T619I","spike_mutations":"E180-, G181-, K182-, E183-, G184-, N185D, F456L"}},"children":[{"name":"KA.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"KA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A2389G","G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.5.103","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.103"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.103"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.166083812713623}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_3ff58fb3","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.46"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.184232234954834}},"branch_attrs":{"mutations":{"nuc":["C5770T","C15279T"]}},"children":[{"name":"GB.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"GB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9350799999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.958531820556306"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["C16338T","C23114G","G28077T","T28297C"],"ORF8":["V62L"],"ORF9b":["I5T"],"S":["L518V"]},"labels":{"aa":"ORF8: V62L; ORF9b: I5T; S: L518V","spike_mutations":"L518V"}}},{"name":"GB.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"GB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G4656A","G8171A","C21622T","A22995G"],"S":["K478R"],"nsp3":["R646Q","A1818T"]},"labels":{"aa":"S: K478R; nsp3: R646Q, A1818T","spike_mutations":"K478R"}}},{"name":"XBB.1.5.46","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.46"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.184232234954834}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_451003c3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.77"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.094293594360352}},"branch_attrs":{"mutations":{"nuc":["T18732C"]}},"children":[{"name":"XBB.1.5.77","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.094293594360352}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000268","node_attrs":{"div":105,"Nextclade_pango":{"value":"HR.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C679T","G1820A","G10364A","C12534T","C16575T","A22995G","C27005T","C28567T","A29147G","T29515A"],"N":["I292V"],"ORF9b":["T95M"],"S":["K478R"],"nsp2":["G339S"],"nsp5":["V104I"],"nsp8":["T148I"]},"labels":{"aa":"N: I292V; ORF9b: T95M; S: K478R; nsp2: G339S; nsp5: V104I; nsp8: T148I","spike_mutations":"K478R"}},"children":[{"name":"HR.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3411T","G9203A","T15717C","A22474C","C27881T"],"S":["K304N"],"nsp3":["A231V"],"nsp4":["D217N"]},"labels":{"aa":"S: K304N; nsp3: A231V; nsp4: D217N","spike_mutations":"K304N"}}},{"name":"HR.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"HR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.77.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_f584d327","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.49"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.816721200942993}},"branch_attrs":{"mutations":{"nuc":["T6886C"]}},"children":[{"name":"HT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"HT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.5930495262146}},"branch_attrs":{"mutations":{"nuc":["T4798C","A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"HT.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"HT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.310773849487305}},"branch_attrs":{"mutations":{"nuc":["C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"XBB.1.5.49","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.49"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.816721200942993}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000270","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.53"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6031T","T21980A","C22498A","G22770A","C23306T"],"S":["F140I","R403K","L582F"]},"labels":{"aa":"S: F140I, R403K, L582F","spike_mutations":"F140I, R403K, L582F"}},"children":[{"name":"XBB.1.5.53","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.5.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000271","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}},"children":[{"name":"JB.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"JB.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.74111"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1576C","C1912T","C4993T","C5869T","C6539T","C15315T","G16221A","T25580C","A28349T"],"N":["S26C"],"ORF3a":["I63T"],"nsp3":["H1274Y"]},"labels":{"aa":"N: S26C; ORF3a: I63T; nsp3: H1274Y"}}}]},{"name":"NODE_0000272","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"JB.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"JB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.5945"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JB.2.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"JB.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.5945"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0935452141087265"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.53.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10333G","C22295T","G23224T"],"S":["H245Y","E554D"]},"labels":{"aa":"S: H245Y, E554D","spike_mutations":"H245Y, E554D"}}}]}]},{"name":"internal_d33f4c5d","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{"nuc":["T11316C"],"nsp6":["M115T"]},"labels":{"aa":"nsp6: M115T"}},"children":[{"name":"FT.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FT.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1241021156311035}},"branch_attrs":{"mutations":{"nuc":["T44C","G22100C"],"S":["E180Q"]},"labels":{"aa":"S: E180Q","spike_mutations":"E180Q"}}},{"name":"XBB.1.5.39","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.024485111236572}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc13afc8","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.5.39"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.5648722648620605}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"nsp2":["S358L"]},"labels":{"aa":"nsp2: S358L"}},"children":[{"name":"FT.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A21390G","G24697T"],"S":["K1045N"]},"labels":{"aa":"S: K1045N","spike_mutations":"K1045N"}}},{"name":"FT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.467785358428955}},"branch_attrs":{"mutations":{"nuc":["A22151G"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}}]},{"name":"internal_747c613f","node_attrs":{"div":96,"Nextclade_pango":{"value":"FT.3"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}},"children":[{"name":"FT.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FT.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.1178364753723145}},"branch_attrs":{"mutations":{}}},{"name":"internal_37080ddf","node_attrs":{"div":100,"Nextclade_pango":{"value":"FT.3.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C6628T","A18366G","A22995G","G25064C"],"S":["K478R","D1168H"]},"labels":{"aa":"S: K478R, D1168H","spike_mutations":"K478R, D1168H"}},"children":[{"name":"FT.3.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FT.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FT.3.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FT.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74638"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0924169334128189"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.39.3.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]}]}]},{"name":"internal_7eece817","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.15"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.800849199295044}},"branch_attrs":{"mutations":{"nuc":["G15957T"]}},"children":[{"name":"FD.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89299"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0707606743218023"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.3"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T8503C","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"XBB.1.5.15","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.5.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.800849199295044}},"branch_attrs":{"mutations":{}}},{"name":"internal_94b75e18","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.1"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["T44C","C4683T","C4993T","C27689T","G27762T"],"ORF7a":["P99L"],"ORF7b":["E3*"],"nsp3":["A655V"]},"labels":{"aa":"ORF7a: P99L; ORF7b: E3*; nsp3: A655V"}},"children":[{"name":"FD.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{}}},{"name":"FD.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.1.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.900310754776001}},"branch_attrs":{"mutations":{"nuc":["C12786T","T22928C"],"S":["F456L"],"nsp9":["T34I"]},"labels":{"aa":"S: F456L; nsp9: T34I","spike_mutations":"F456L"}}}]},{"name":"internal_07fb4e92","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.2"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{"nuc":["G1820A","C21998A"],"S":["Q146K"],"nsp2":["G339S"]},"labels":{"aa":"S: Q146K; nsp2: G339S","spike_mutations":"Q146K"}},"children":[{"name":"FD.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-3.945685863494873}},"branch_attrs":{"mutations":{}}},{"name":"FD.2.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FD.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.2.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","G9329A","G26834A"],"nsp4":["D259N"]},"labels":{"aa":"nsp4: D259N"}}}]},{"name":"internal_1ee75ec0","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.4"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{"nuc":["G12838T"],"nsp9":["L51F"]},"labels":{"aa":"nsp9: L51F"}},"children":[{"name":"FD.4.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FD.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4.1"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C13329T","A21367T"],"nsp10":["T102I"],"nsp16":["I237F"]},"labels":{"aa":"nsp10: T102I; nsp16: I237F"}}},{"name":"FD.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"FD.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23A (XBB.1.5)"},"partiallyAliased":{"value":"XBB.1.5.15.4"},"clade_nextstrain":{"value":"23A"},"clade_membership":{"value":"23A"},"placement_prior":{"value":-4.376571178436279}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"NODE_0000281","node_attrs":{"div":91,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.78318452835083}},"branch_attrs":{"mutations":{"nuc":["T28297C"],"ORF9b":["I5T"]},"labels":{"aa":"ORF9b: I5T"}},"children":[{"name":"XBB.1.25","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.25"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.561348915100098}},"branch_attrs":{"mutations":{"nuc":["G487T","C673T","-29759G"]}}},{"name":"XBB.1.26","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.26"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.335569858551025}},"branch_attrs":{"mutations":{"nuc":["T10663C"]}}},{"name":"internal_XBB_1_22","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.22"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.213903903961182}},"branch_attrs":{"mutations":{"nuc":["T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"XBB.1.22","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.213903903961182}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.22.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C10776T","C18979A"],"nsp14":["H314N"],"nsp5":["P241L"]},"labels":{"aa":"nsp14: H314N; nsp5: P241L"}}},{"name":"NODE_0000283","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{"nuc":["C11750T","A12316G","C15237T","A27507C"],"nsp6":["L260F"]},"labels":{"aa":"nsp6: L260F"}},"children":[{"name":"HU.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"HU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T44C","G336A","C17750T","C21789T","T22684C","A26126G"],"ORF3a":["Q245R"],"S":["T76I"],"nsp1":["R24H"],"nsp13":["A505V"]},"labels":{"aa":"ORF3a: Q245R; S: T76I; nsp1: R24H; nsp13: A505V","spike_mutations":"T76I"}}},{"name":"XBB.1.22.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.795171737670898}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000284","node_attrs":{"div":98,"Nextclade_pango":{"value":"HU.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C2881T","G23149T"],"S":["K529N"]},"labels":{"aa":"S: K529N","spike_mutations":"K529N"}},"children":[{"name":"HU.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"HU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86018"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.950188045949472"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"HU.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"HU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.67693"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9788766097021935"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.2.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A17910G","C18252T","T21644C","G22973C","T24850C"],"S":["Y28H","E471Q"]},"labels":{"aa":"S: Y28H, E471Q","spike_mutations":"Y28H, E471Q"}}}]}]},{"name":"internal_f7b45518","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{"nuc":["T44C","A22161G"],"S":["Y200C"]},"labels":{"aa":"S: Y200C","spike_mutations":"Y200C"}},"children":[{"name":"FY.9","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.9"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C925A","G2265A","C23585A"],"S":["Q675K"],"nsp2":["D40E","C487Y"]},"labels":{"aa":"S: Q675K; nsp2: D40E, C487Y","spike_mutations":"Q675K"}}},{"name":"XBB.1.22.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.22.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.547635555267334}},"branch_attrs":{"mutations":{}}},{"name":"internal_510fd725","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T16456C","T22152C"],"S":["I197T"],"nsp13":["S74P"]},"labels":{"aa":"S: I197T; nsp13: S74P","spike_mutations":"I197T"}},"children":[{"name":"FY.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"FY.2.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C5886T","C23613T","A28699G"],"S":["A684V"],"nsp3":["T1056I"]},"labels":{"aa":"S: A684V; nsp3: T1056I","spike_mutations":"A684V"}}}]},{"name":"internal_87efaafa","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["C2037T"],"nsp2":["A411V"]},"labels":{"aa":"nsp2: A411V"}},"children":[{"name":"FY.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"internal_40f1a96d","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.6"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.387897491455078}},"branch_attrs":{"mutations":{"nuc":["C44T","T17124C"]}},"children":[{"name":"FY.6.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FY.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3500T","T6736C","C24378T","G27798T","G29543A"],"ORF7b":["A15S"],"S":["S939F"],"nsp3":["T261S"]},"labels":{"aa":"ORF7b: A15S; S: S939F; nsp3: T261S","spike_mutations":"S939F"}}},{"name":"FY.6.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.6.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C9693T","T11269C","G25699A"],"ORF3a":["A103T"],"nsp4":["A380V"]},"labels":{"aa":"ORF3a: A103T; nsp4: A380V"}}}]}]},{"name":"internal_6ee4f269","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.8"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"FY.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{}}},{"name":"internal_d9f0425a","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.8.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4579A","C18511T","A22995G"],"S":["K478R"],"nsp14":["P158S"]},"labels":{"aa":"S: K478R; nsp14: P158S","spike_mutations":"K478R"}},"children":[{"name":"FY.8.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.8.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FY.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8926499999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.8.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G16912T","C23124A","C26681T","C29296T"],"S":["P521Q"],"nsp13":["V226L"]},"labels":{"aa":"S: P521Q; nsp13: V226L","spike_mutations":"P521Q"}}}]}]},{"name":"internal_cbbd3c8c","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.3"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{"nuc":["G2513A","C23191T"],"nsp2":["E570K"]},"labels":{"aa":"nsp2: E570K"}},"children":[{"name":"FY.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.611515522003174}},"branch_attrs":{"mutations":{}}},{"name":"FY.3.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-3.86080265045166}},"branch_attrs":{"mutations":{"nuc":["G4109T","C5544T","T22191C"],"S":["I210T"],"nsp3":["D464Y","T942I"]},"labels":{"aa":"S: I210T; nsp3: D464Y, T942I","spike_mutations":"I210T"}}},{"name":"FY.3.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["A11556G"],"nsp6":["E195G"]},"labels":{"aa":"nsp6: E195G"}}},{"name":"FY.3.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.3.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C44T","G25534T"],"ORF3a":["V48F"]},"labels":{"aa":"ORF3a: V48F"}}}]},{"name":"internal_9c1b5374","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.22.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A8374G","C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}},"children":[{"name":"FY.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.7"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11674T","T22246G","G23868C","C24442T","C25066A","A25974G","C27429T","C28603T"],"S":["D228E","G769A","D1168E"]},"labels":{"aa":"S: D228E, G769A, D1168E","spike_mutations":"D228E, G769A, D1168E"}}},{"name":"internal_c773bde4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{"nuc":["T22913C"],"S":["Y451H"]},"labels":{"aa":"S: Y451H","spike_mutations":"Y451H"}},"children":[{"name":"FY.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80106"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-6.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.80106"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9530703986942458"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A6777T","C7417T","G20326A"],"nsp15":["V236I"],"nsp3":["Y1353F"]},"labels":{"aa":"nsp15: V236I; nsp3: Y1353F"}}},{"name":"NODE_0000294","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.4.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"FY.4.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.051291465759277}},"branch_attrs":{"mutations":{}}},{"name":"FY.4.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"FY.4.1.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9828941175755879"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.4.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C9042T"],"nsp4":["S163F"]},"labels":{"aa":"nsp4: S163F"}}}]}]}]},{"name":"internal_4cac9310","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FY.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.183231353759766}},"branch_attrs":{"mutations":{}}},{"name":"internal_8688708a","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.5.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5312A","C23277T","T26921C"],"S":["T572I"],"nsp3":["L865I"]},"labels":{"aa":"S: T572I; nsp3: L865I","spike_mutations":"T572I"}},"children":[{"name":"FY.5.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A610T","G13313A","C21057T","G22021T","T22119C","G22302A"],"S":["M153I","F186S","S247N"],"nsp10":["V97I"]},"labels":{"aa":"S: M153I, F186S, S247N; nsp10: V97I","spike_mutations":"M153I, F186S, S247N"}}}]},{"name":"internal_abb9d504","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.610250949859619}},"branch_attrs":{"mutations":{"nuc":["A6019G"]}},"children":[{"name":"FY.5.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C44T","C22088T","G28300A"],"ORF9b":["S6N"],"S":["L176F"]},"labels":{"aa":"ORF9b: S6N; S: L176F","spike_mutations":"L176F"}}},{"name":"FY.5.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A802G","C22227T","C22978T","G29779T"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"FY.5.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G9290A","A12495G","C14016T","C18252T","C23277T"],"S":["T572I"],"nsp4":["D246N"],"nsp8":["Y135C"]},"labels":{"aa":"S: T572I; nsp4: D246N; nsp8: Y135C","spike_mutations":"T572I"}}},{"name":"internal_ba034a15","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.5"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G8653C","T9616C","T18408C"],"nsp4":["M33I"]},"labels":{"aa":"nsp4: M33I"}},"children":[{"name":"FY.5.5","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FY.5.5.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FY.5.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.5.5.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]},{"name":"internal_eaa00801","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393481731414795}},"branch_attrs":{"mutations":{"nuc":["G18811A"],"nsp14":["D258N"]},"labels":{"aa":"nsp14: D258N"}},"children":[{"name":"FY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.393481731414795}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"FY.1.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FY.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"internal_d4a15f8a","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.4"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","A19134G","C21552T","A22995G","A24813G","C25836T"],"S":["K478R","D1084G"]},"labels":{"aa":"S: K478R, D1084G","spike_mutations":"K478R, D1084G"}},"children":[{"name":"FY.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.4.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FY.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.4.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C3157A","T4846C","C18431T","T23268C","G29766T"],"S":["I569T"],"nsp14":["T131I"]},"labels":{"aa":"S: I569T; nsp14: T131I","spike_mutations":"I569T"}}}]},{"name":"NODE_0000301","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{"nuc":["C11575T","C14120T","C23277T"],"S":["T572I"],"nsp12":["P227L"]},"labels":{"aa":"S: T572I; nsp12: P227L","spike_mutations":"T572I"}},"children":[{"name":"FY.1.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.01540470123291}},"branch_attrs":{"mutations":{}}},{"name":"FY.1.2.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FY.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["T4579A","C5055T","T13447A","G21753T","C21910T"],"S":["W64L"],"nsp3":["T779I"]},"labels":{"aa":"S: W64L; nsp3: T779I","spike_mutations":"W64L"}}},{"name":"internal_6436aedc","node_attrs":{"div":99,"Nextclade_pango":{"value":"FY.1.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A13947C"]}},"children":[{"name":"FY.1.2.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FY.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["G24947A","A28704G"],"N":["D144G"],"S":["V1129I"]},"labels":{"aa":"N: D144G; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FY.1.2.3","node_attrs":{"div":104,"Nextclade_pango":{"value":"FY.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.22.1.1.2.3"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3874T","C13225T","G22205C","C28153A","G28487A"],"N":["V72I"],"ORF8":["T87K"],"S":["D215H"]},"labels":{"aa":"N: V72I; ORF8: T87K; S: D215H","spike_mutations":"D215H"}}}]}]}]}]}]},{"name":"NODE_0000303","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-2.995669364929199}},"branch_attrs":{"mutations":{"nuc":["C11750T","C11956T","T12730A","A14856G","G18703T","A22101T","A22995G","T23018C","A28447G","C29386T"],"ORF9b":["N55S"],"S":["E180V","K478R","S486P"],"nsp14":["D222Y"],"nsp6":["L260F"]},"labels":{"aa":"ORF9b: N55S; S: E180V, K478R, S486P; nsp14: D222Y; nsp6: L260F","clade":"23B","spike_mutations":"E180V, K478R, S486P"}},"children":[{"name":"XBB.1.16","node_attrs":{"div":101,"Nextclade_pango":{"value":"XBB.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-2.995669364929199}},"branch_attrs":{"mutations":{}}},{"name":"XBB.1.16.11","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.11"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.181058883666992}},"branch_attrs":{"mutations":{"nuc":["C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}},{"name":"XBB.1.16.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.12"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.213220119476318}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.10","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.10"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.275190830230713}},"branch_attrs":{"mutations":{"nuc":["G28347A"],"N":["G25D"],"ORF9b":["A22T"]},"labels":{"aa":"N: G25D; ORF9b: A22T"}}},{"name":"XBB.1.16.14","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7388600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0744467131509066"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.14"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.313371181488037}},"branch_attrs":{"mutations":{"nuc":["A11782G","T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","spike_mutations":"L452Q"}}},{"name":"XBB.1.16.16","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.368899345397949}},"branch_attrs":{"mutations":{"nuc":["G23401T","G29508A"],"N":["S412N"],"S":["Q613H"]},"labels":{"aa":"N: S412N; S: Q613H","spike_mutations":"Q613H"}}},{"name":"XBB.1.16.17","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.17"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.14486837387085}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"XBB.1.16.18","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.18"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.089405536651611}},"branch_attrs":{"mutations":{"nuc":["C27509T"],"ORF7a":["T39I"]},"labels":{"aa":"ORF7a: T39I"}}},{"name":"XBB.1.16.20","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.20"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.060710906982422}},"branch_attrs":{"mutations":{"nuc":["C27847T"],"ORF7b":["S31L"]},"labels":{"aa":"ORF7b: S31L"}}},{"name":"XBB.1.16.19","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.19"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.188409805297852}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"nsp12":["V848I"]},"labels":{"aa":"nsp12: V848I"}}},{"name":"XBB.1.16.23","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.23"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.350697994232178}},"branch_attrs":{"mutations":{"nuc":["T11449C","A22472C"],"S":["K304Q"]},"labels":{"aa":"S: K304Q","spike_mutations":"K304Q"}}},{"name":"XBB.1.16.21","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.21"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.154815673828125}},"branch_attrs":{"mutations":{"nuc":["G12479A"],"nsp8":["V130I"]},"labels":{"aa":"nsp8: V130I"}}},{"name":"XBB.1.16.24","node_attrs":{"div":111,"Nextclade_pango":{"value":"XBB.1.16.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.24"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T2C","T44C","T2242C","C2508T","G3179A","A22106G","C23123A","G23213A","G23222A","A25410G"],"S":["K182E","P521T","V551I","E554K"],"nsp2":["P568L"],"nsp3":["E154K"]},"labels":{"aa":"S: K182E, P521T, V551I, E554K; nsp2: P568L; nsp3: E154K","spike_mutations":"K182E, P521T, V551I, E554K"}}},{"name":"XBB.1.16.22","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.22"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.469313621520996}},"branch_attrs":{"mutations":{"nuc":["G26116C"],"ORF3a":["E242Q"]},"labels":{"aa":"ORF3a: E242Q"}}},{"name":"XBB.1.16.28","node_attrs":{"div":107,"Nextclade_pango":{"value":"XBB.1.16.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.28"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G3246A","T13518C","T17250G","G23401T","C23585A","T25251C"],"S":["Q613H","Q675K","V1230A"],"nsp3":["S176N"]},"labels":{"aa":"S: Q613H, Q675K, V1230A; nsp3: S176N","spike_mutations":"Q613H, Q675K, V1230A"}}},{"name":"XBB.1.16.26","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.26"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.182722091674805}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}}},{"name":"XBB.1.16.25","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.25"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A1793G","C16611T","A29221G"],"nsp2":["K330E"]},"labels":{"aa":"nsp2: K330E"}}},{"name":"XBB.1.16.27","node_attrs":{"div":116,"Nextclade_pango":{"value":"XBB.1.16.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.27"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G3153A","A6399G","C7720T","T11081C","G11083T","G11930A","T12673C","T19065G","C20133T","T20484C","C20628T","T22928C","G23222A","T26171C","A28984G"],"ORF3a":["M260T"],"S":["F456L","E554K"],"nsp3":["G145D","K1227R"],"nsp7":["A30T"]},"labels":{"aa":"ORF3a: M260T; S: F456L, E554K; nsp3: G145D, K1227R; nsp7: A30T","spike_mutations":"F456L, E554K"}}},{"name":"XBB.1.16.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.554114818572998}},"branch_attrs":{"mutations":{"nuc":["A2893C"]}}},{"name":"XBB.1.16.5","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.220455169677734}},"branch_attrs":{"mutations":{"nuc":["T44C","T9991C","C16332T"]}}},{"name":"XBB.1.16.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.503280162811279}},"branch_attrs":{"mutations":{"nuc":["C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"XBB.1.16.8","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.8"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.047262191772461}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"XBB.1.16.7","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.1.16.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.7"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T3533C","T12214C","T17154C","C23757T"],"S":["T732I"],"nsp3":["Y272H"]},"labels":{"aa":"S: T732I; nsp3: Y272H","spike_mutations":"T732I"}}},{"name":"XBB.1.16.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.9"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.036108016967773}},"branch_attrs":{"mutations":{"nuc":["C7764T","T22930G","T27591C"],"S":["F456L"],"nsp3":["S1682F"]},"labels":{"aa":"S: F456L; nsp3: S1682F","spike_mutations":"F456L"}}},{"name":"NODE_0000304","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.32"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{"nuc":["C6541T","A8080G","A8425G","T21823C","T23030C"],"S":["S490P"]},"labels":{"aa":"S: S490P","spike_mutations":"S490P"}},"children":[{"name":"KJ.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64385"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","T5122C","C5241T","C6190T","C11494T","C23280T","A24994G","T27900C"],"ORF8":["F3L"],"S":["T573I"],"nsp3":["P841L"]},"labels":{"aa":"ORF8: F3L; S: T573I; nsp3: P841L","spike_mutations":"T573I"}}},{"name":"XBB.1.16.32","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.64385"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.32"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.961173057556152}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000305","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.15"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["T10756C","T14067C","A22003T","C23123T","C27513T"],"S":["K147N","P521S"]},"labels":{"aa":"S: K147N, P521S","spike_mutations":"K147N, P521S"}},"children":[{"name":"JM.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G21796T","C22480T","G25135A"],"S":["R78S"]},"labels":{"aa":"S: R78S","spike_mutations":"R78S"}}},{"name":"JM.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"JM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["G2059A","G21718T","A24019G","G29227T"],"S":["Q52H"],"nsp2":["M418I"]},"labels":{"aa":"S: Q52H; nsp2: M418I","spike_mutations":"Q52H"}}},{"name":"XBB.1.16.15","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.15"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000306","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.32681131362915}},"branch_attrs":{"mutations":{"nuc":["C7765T"]}},"children":[{"name":"XBB.1.16.29","node_attrs":{"div":107,"Nextclade_pango":{"value":"XBB.1.16.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.29"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7081T","G11083T","T18703G","T22912C","C24210T"],"S":["T883I"],"nsp14":["Y222D"],"nsp6":["L37F"]},"labels":{"aa":"S: T883I; nsp14: Y222D; nsp6: L37F","spike_mutations":"T883I"}}},{"name":"XBB.1.16.30","node_attrs":{"div":105,"Nextclade_pango":{"value":"XBB.1.16.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.30"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23222C","T25779C","A29499G"],"N":["Q409R"],"S":["E554Q"]},"labels":{"aa":"N: Q409R; S: E554Q","spike_mutations":"E554Q"}}},{"name":"XBB.1.16.31","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.31"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6403045654296875}},"branch_attrs":{"mutations":{"nuc":["T9004C"]}}}]},{"name":"internal_4934b995","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.13"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3567A"],"nsp2":["G339S"],"nsp3":["G283D"]},"labels":{"aa":"nsp2: G339S; nsp3: G283D"}},"children":[{"name":"XBB.1.16.13","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6024370193481445}},"branch_attrs":{"mutations":{}}},{"name":"internal_ef800d5e","node_attrs":{"div":106,"Nextclade_pango":{"value":"HF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{"nuc":["C17949T","A22474C","C25006T"],"S":["K304N"]},"labels":{"aa":"S: K304N","spike_mutations":"K304N"}},"children":[{"name":"HF.1.2","node_attrs":{"div":108,"Nextclade_pango":{"value":"HF.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.093987464904785}},"branch_attrs":{"mutations":{"nuc":["C3737T","C23625T"],"S":["A688V"],"nsp3":["P340S"]},"labels":{"aa":"S: A688V; nsp3: P340S","spike_mutations":"A688V"}}},{"name":"HF.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"HF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9202959537506104}},"branch_attrs":{"mutations":{}}},{"name":"HF.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"HF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.13.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C6627T","C7006T","C13994T","G17149T","C24863T","G28376A"],"N":["A35T"],"S":["H1101Y"],"nsp12":["A185V"],"nsp13":["V305L"],"nsp3":["T1303I"]},"labels":{"aa":"N: A35T; S: H1101Y; nsp12: A185V; nsp13: V305L; nsp3: T1303I","spike_mutations":"H1101Y"}}}]}]},{"name":"NODE_0000309","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{"nuc":["C8947T","A12397G","T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"XBB.1.16.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"XBB.1.16.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.265481948852539}},"branch_attrs":{"mutations":{}}},{"name":"internal_adf0d069","node_attrs":{"div":106,"Nextclade_pango":{"value":"XBB.1.16.6"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.1121838092803955}},"branch_attrs":{"mutations":{"nuc":["A10861G","T23986C"]}},"children":[{"name":"JF.3","node_attrs":{"div":112,"Nextclade_pango":{"value":"JF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1514T","A12759G","G21604T","G22927T","C23991T","C28657T"],"S":["Q14H","L455F","S810L"],"nsp2":["H237Y"],"nsp9":["D25G"]},"labels":{"aa":"S: Q14H, L455F, S810L; nsp2: H237Y; nsp9: D25G","spike_mutations":"Q14H, L455F, S810L"}}},{"name":"JF.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A976T","G23587T","G28166C"],"ORF8":["Q91H"],"S":["Q675H"],"nsp2":["E57D"]},"labels":{"aa":"ORF8: Q91H; S: Q675H; nsp2: E57D","spike_mutations":"Q675H"}}},{"name":"JF.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"JF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.8289549350738525}},"branch_attrs":{"mutations":{"nuc":["C900T","C27937T"],"ORF8":["A15V"],"nsp2":["S32L"]},"labels":{"aa":"ORF8: A15V; nsp2: S32L"}}},{"name":"internal_a68d6fb2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JF.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"JF.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.236754894256592}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000312","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{"nuc":["C3874T","C6354T"],"nsp3":["S1212L"]},"labels":{"aa":"nsp3: S1212L"}},"children":[{"name":"JF.1.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"JF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.2326700000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6278T","C22986T","G29645A"],"ORF10":["V30I"],"S":["A475V"],"nsp3":["P1187S"]},"labels":{"aa":"ORF10: V30I; S: A475V; nsp3: P1187S","spike_mutations":"A475V"}}},{"name":"JF.1.1.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"JF.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JF.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.6.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.028478622436523}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_9df31b5b","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"FU.4","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.14642"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0306074934635072"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A22920T","T29410C"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"FU.5","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1889T","A17295G","C17430T","A21851G"],"S":["K97E"],"nsp2":["R362C"]},"labels":{"aa":"S: K97E; nsp2: R362C","spike_mutations":"K97E"}}},{"name":"XBB.1.16.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.4123260974884033}},"branch_attrs":{"mutations":{}}},{"name":"internal_96ac0a1b","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{"nuc":["T44C","C8692T"]}},"children":[{"name":"FU.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.045390605926514}},"branch_attrs":{"mutations":{}}},{"name":"FU.2.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["T241A","C6582A","A12526T","G23417C"],"S":["E619Q"],"nsp3":["T1288N"]},"labels":{"aa":"S: E619Q; nsp3: T1288N","spike_mutations":"E619Q"}}}]},{"name":"internal_589e1bd1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.3"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{"nuc":["C11665T"]}},"children":[{"name":"FU.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FU.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}}},{"name":"FU.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.961516380310059}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000316","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{"nuc":["T3802C"]}},"children":[{"name":"FU.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.7045421600341797}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000317","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2G","A25359G","A26708G"],"S":["K1266R"]},"labels":{"aa":"S: K1266R","spike_mutations":"K1266R"}},"children":[{"name":"FU.1.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FU.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C5301T","A21783G"],"S":["N74S"],"nsp3":["A861V"]},"labels":{"aa":"S: N74S; nsp3: A861V","spike_mutations":"N74S"}}},{"name":"FU.1.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FU.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"internal_bc45682f","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{"nuc":["C3042A","G25429C"],"ORF3a":["V13L"],"nsp3":["P108H"]},"labels":{"aa":"ORF3a: V13L; nsp3: P108H"}},"children":[{"name":"GY.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.3"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["G22093C","C26753T"],"S":["M177I"]},"labels":{"aa":"S: M177I","spike_mutations":"M177I"}}},{"name":"GY.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"GY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8164899999999998"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.4"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1348T","T22912G","C29095T"],"S":["N450K"]},"labels":{"aa":"S: N450K","spike_mutations":"N450K"}}},{"name":"GY.5","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.5"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G9190C"]}}},{"name":"GY.6","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.6"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["G5558A"],"nsp3":["V947I"]},"labels":{"aa":"nsp3: V947I"}}},{"name":"GY.7","node_attrs":{"div":107,"Nextclade_pango":{"value":"GY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.7"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T44C","G5515T","G11114T","T29867C"],"nsp6":["G48C"]},"labels":{"aa":"nsp6: G48C"}}},{"name":"GY.8","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.8"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["T22928C","C25452T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"GY.9","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.9"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.012420177459717}},"branch_attrs":{"mutations":{"nuc":["T22119C","T22292C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"XBB.1.16.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"XBB.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-3.9689269065856934}},"branch_attrs":{"mutations":{}}},{"name":"internal_85eaf595","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.2"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}},"children":[{"name":"GY.2.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"GY.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"GY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.2"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000320","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G12467T","C21812A"],"S":["L84I"],"nsp8":["A126S"]},"labels":{"aa":"S: L84I; nsp8: A126S","spike_mutations":"L84I"}},"children":[{"name":"GY.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"GY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{}}},{"name":"internal_4bba6217","node_attrs":{"div":108,"Nextclade_pango":{"value":"GY.1.1"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C19380T","G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"GY.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"GY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"GY.1.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"GY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.2326700000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2814666878404952"},"clade_display":{"value":"23B (XBB.1.16)"},"partiallyAliased":{"value":"XBB.1.16.2.1.1.1"},"clade_nextstrain":{"value":"23B"},"clade_membership":{"value":"23B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T44C","C1091T","C3117T","G3452A","C11020T","T15276C","C22986T"],"S":["A475V"],"nsp2":["P96S"],"nsp3":["T133I","V245I"]},"labels":{"aa":"S: A475V; nsp2: P96S; nsp3: T133I, V245I","spike_mutations":"A475V"}}}]}]}]}]},{"name":"internal_bbead6fe","node_attrs":{"div":92,"Nextclade_pango":{"value":"XBB.1"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.09637451171875}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}},"children":[{"name":"XBB.1.23","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.23"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C26447T","C29203T","-29759G"],"E":["S68F"]},"labels":{"aa":"E: S68F"}}},{"name":"NODE_0000323","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.42"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["A16878T","T23018C","G23401T"],"S":["S486P","Q613H"]},"labels":{"aa":"S: S486P, Q613H","spike_mutations":"S486P, Q613H"}},"children":[{"name":"XBB.1.42","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.806872844696045}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.42.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.141610145568848}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"NODE_0000324","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.42.2"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{"nuc":["C6040T","G9049A"]}},"children":[{"name":"HL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"HL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2.1"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2143T","G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"HL.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"HL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.941244602203369}},"branch_attrs":{"mutations":{"nuc":["C6114A","G24348A"],"S":["S929N"],"nsp3":["P1132H"]},"labels":{"aa":"S: S929N; nsp3: P1132H","spike_mutations":"S929N"}}},{"name":"XBB.1.42.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.42.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"22F (XBB)"},"partiallyAliased":{"value":"XBB.1.42.2"},"clade_nextstrain":{"value":"22F"},"clade_membership":{"value":"22F"},"placement_prior":{"value":-4.191346168518066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_XBB.1.9.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.9"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.211273193359375}},"branch_attrs":{"mutations":{"nuc":["G5720A"],"nsp3":["G1001S"]},"labels":{"aa":"nsp3: G1001S","clade":"23D"}},"children":[{"name":"XBB.1.9","node_attrs":{"div":93,"Nextclade_pango":{"value":"XBB.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.211273193359375}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"XBB.1.9.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.9.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["C28603T","-29759G"]}}},{"name":"XBB.1.9.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"XBB.1.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["T2152G"],"nsp2":["D449E"]},"labels":{"aa":"nsp2: D449E"}}},{"name":"XBB.1.9.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"XBB.1.9.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","C3317A","C6500T","G13459A","A22995G","T23018C"],"S":["K478R","S486P"],"nsp3":["P200T","P1261S"]},"labels":{"aa":"S: K478R, S486P; nsp3: P200T, P1261S","spike_mutations":"K478R, S486P"}}},{"name":"XBB.1.9.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"XBB.1.9.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13558"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0724478315077164"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T446C","T1147C","C3165T","A15196G","G22770A","G23270A","C26936T","G27201T","C27881A"],"ORF7b":["H42Q"],"S":["R403K","A570T"],"nsp12":["T586A"],"nsp3":["A149V"]},"labels":{"aa":"ORF7b: H42Q; S: R403K, A570T; nsp12: T586A; nsp3: A149V","spike_mutations":"R403K, A570T"}}},{"name":"NODE_0000326","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.9.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{"nuc":["G18169T","G19480A"],"nsp14":["G44C","G481S"]},"labels":{"aa":"nsp14: G44C, G481S"}},"children":[{"name":"GD.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"GD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.6875"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0109791747614623"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.331232070922852}},"branch_attrs":{"mutations":{"nuc":["T44C","C6286T","A22920T"],"S":["Y453F"]},"labels":{"aa":"S: Y453F","spike_mutations":"Y453F"}}},{"name":"GD.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"GD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.068836212158203}},"branch_attrs":{"mutations":{"nuc":["T44C","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"GD.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"GD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["A12644G","T21737C","C26570T"],"S":["F59L"],"nsp8":["I185V"]},"labels":{"aa":"S: F59L; nsp8: I185V","spike_mutations":"F59L"}}},{"name":"XBB.1.9.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"XBB.1.9.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40686999999999995"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.036220073699951}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000327","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.3896050453186035}},"branch_attrs":{"mutations":{"nuc":["T44C","C11956T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"FL.12","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.12"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.063467979431152}},"branch_attrs":{"mutations":{"nuc":["G6894T"],"nsp3":["C1392F"]},"labels":{"aa":"nsp3: C1392F"}}},{"name":"FL.11","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1312T","C9073T","A11782G","C28462T"],"ORF9b":["T60I"],"nsp2":["L169F"]},"labels":{"aa":"ORF9b: T60I; nsp2: L169F"}}},{"name":"FL.14","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.14"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.23352575302124}},"branch_attrs":{"mutations":{"nuc":["T2C","C22978T","G24926A","C29311T"],"S":["V1122M"]},"labels":{"aa":"S: V1122M","spike_mutations":"V1122M"}}},{"name":"FL.16","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.16"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.427809715270996}},"branch_attrs":{"mutations":{"nuc":["C3511T","A22206T"],"S":["D215V"]},"labels":{"aa":"S: D215V","spike_mutations":"D215V"}}},{"name":"FL.18","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0403361320495605}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"nsp3":["T1189I"]},"labels":{"aa":"nsp3: T1189I"}}},{"name":"FL.22","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.22"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.301856517791748}},"branch_attrs":{"mutations":{"nuc":["A17713G","T24184C"],"nsp13":["I493V"]},"labels":{"aa":"nsp13: I493V"}}},{"name":"FL.25","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.25"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.532011985778809}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.28","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.28"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4824T","C7573T","G12769A","C13554T","C16887T","A22995G","G25595T","C29870A"],"ORF3a":["R68I"],"S":["K478R"],"nsp3":["S702F"]},"labels":{"aa":"ORF3a: R68I; S: K478R; nsp3: S702F","spike_mutations":"K478R"}}},{"name":"FL.27","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.27"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.406124591827393}},"branch_attrs":{"mutations":{"nuc":["G11504A"],"nsp6":["V178I"]},"labels":{"aa":"nsp6: V178I"}}},{"name":"FL.29","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7904599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.29"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.6592278480529785}},"branch_attrs":{"mutations":{"nuc":["A20458G","T23030C"],"S":["S490P"],"nsp15":["I280V"]},"labels":{"aa":"S: S490P; nsp15: I280V","spike_mutations":"S490P"}}},{"name":"FL.34","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.34"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24914T","C25614T","G26959A"],"M":["R146H"],"S":["D1118Y"]},"labels":{"aa":"M: R146H; S: D1118Y","spike_mutations":"D1118Y"}}},{"name":"FL.36","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.36"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G12038A","G22132T","A22629C","C23277T","G24257T","G24770A"],"S":["R190S","K356T","T572I","A899S","A1070T"],"nsp7":["V66I"]},"labels":{"aa":"S: R190S, K356T, T572I, A899S, A1070T; nsp7: V66I","spike_mutations":"R190S, K356T, T572I, A899S, A1070T"}}},{"name":"FL.37","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.37"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.926265716552734}},"branch_attrs":{"mutations":{"nuc":["C547T","C29614T"]}}},{"name":"FL.40","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.40"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.216498374938965}},"branch_attrs":{"mutations":{"nuc":["A11537G","C27684T"],"nsp6":["I189V"]},"labels":{"aa":"nsp6: I189V"}}},{"name":"FL.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.937436580657959}},"branch_attrs":{"mutations":{"nuc":["A2810G"],"nsp3":["I31V"]},"labels":{"aa":"nsp3: I31V"}}},{"name":"FL.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.1645684242248535}},"branch_attrs":{"mutations":{"nuc":["A25576T"],"ORF3a":["I62F"]},"labels":{"aa":"ORF3a: I62F"}}},{"name":"FL.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.511373996734619}},"branch_attrs":{"mutations":{"nuc":["C222T","C21714T"],"S":["T51I"]},"labels":{"aa":"S: T51I","spike_mutations":"T51I"}}},{"name":"FL.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.411857604980469}},"branch_attrs":{"mutations":{"nuc":["C23707T","T29691C"]}}},{"name":"XBB.1.9.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"XBB.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.3896050453186035}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000328","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.18.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C6285T","G12907A","A27507C","C28770T"],"N":["T166I"],"nsp3":["T1189I"]},"labels":{"aa":"N: T166I; nsp3: T1189I"}},"children":[{"name":"FL.18.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"FL.18.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.18.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.18.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","C15390A","A22161G","A22995G","T26457C"],"S":["Y200C","K478R"],"nsp12":["H650Q"],"nsp2":["G339S"]},"labels":{"aa":"S: Y200C, K478R; nsp12: H650Q; nsp2: G339S","spike_mutations":"Y200C, K478R"}}}]},{"name":"internal_d2a6176a","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.19"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","T2377C","C17502T","T24505G"]}},"children":[{"name":"FL.19.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C367T","T12145C","C12952T","C19097T","T22928C","G24757T"],"S":["F456L"],"nsp14":["A353V"]},"labels":{"aa":"S: F456L; nsp14: A353V","spike_mutations":"F456L"}}},{"name":"FL.19","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.19"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b97dbddb","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.24"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A15082G","C22570T","G23401T","C23625T","A25637G"],"ORF3a":["N82S"],"S":["Q613H","A688V"],"nsp12":["I548V"]},"labels":{"aa":"ORF3a: N82S; S: Q613H, A688V; nsp12: I548V","spike_mutations":"Q613H, A688V"}},"children":[{"name":"FL.24","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{}}},{"name":"FL.24.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.24.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.295958995819092}},"branch_attrs":{"mutations":{"nuc":["T9139C","A22995G","C24919T"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_ea1eda9d","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.26"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{"nuc":["C22264T"]}},"children":[{"name":"FL.26","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.451239585876465}},"branch_attrs":{"mutations":{}}},{"name":"FL.26.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0848"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9957660361777405"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.26.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3852T","A21661C","A23040T","C25658T"],"ORF3a":["T89I"],"S":["Q493L"],"nsp3":["E378V"]},"labels":{"aa":"ORF3a: T89I; S: Q493L; nsp3: E378V","spike_mutations":"Q493L"}}}]},{"name":"NODE_0000332","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.30"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["G500A","C7303T","C22858T","G23012A","C23013A"],"S":["A484K"],"nsp1":["A79T"]},"labels":{"aa":"S: A484K; nsp1: A79T","spike_mutations":"A484K"}},"children":[{"name":"FL.30.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.30.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90046"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G24116T"],"S":["A852S"]},"labels":{"aa":"S: A852S","spike_mutations":"A852S"}}},{"name":"FL.30","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.90046"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.020189608544247"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.30"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17747A","T19530C","C20405T"],"nsp13":["P504H"],"nsp15":["P262L"]},"labels":{"aa":"nsp13: P504H; nsp15: P262L"}}}]},{"name":"NODE_0000333","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.31"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G12769T","G15438T"],"nsp12":["M666I"]},"labels":{"aa":"nsp12: M666I"}},"children":[{"name":"FL.31.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C882T","G2265A","A3417G","C16575T","G21800C","A22995G","G23401T","G25471C","C28236T"],"ORF3a":["D27H"],"ORF8":["R115C"],"S":["D80H","K478R","Q613H"],"nsp2":["A26V","C487Y"],"nsp3":["K233R"]},"labels":{"aa":"ORF3a: D27H; ORF8: R115C; S: D80H, K478R, Q613H; nsp2: A26V, C487Y; nsp3: K233R","spike_mutations":"D80H, K478R, Q613H"}}},{"name":"FL.31","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.31"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000334","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.32"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G7331A","G21578C","C21952T","G23222C","C28657T"],"S":["V6L","E554Q"],"nsp3":["V1538I"]},"labels":{"aa":"S: V6L, E554Q; nsp3: V1538I","spike_mutations":"V6L, E554Q"}},"children":[{"name":"FL.32","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.32.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.32.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T13339C","C19961T","T22928C","C25572T"],"S":["F456L"],"nsp15":["T114M"]},"labels":{"aa":"S: F456L; nsp15: T114M","spike_mutations":"F456L"}}}]},{"name":"internal_05e5e308","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.33"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{"nuc":["C17597T"],"nsp13":["A454V"]},"labels":{"aa":"nsp13: A454V"}},"children":[{"name":"FL.33.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.33.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.515425205230713}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.33","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.33"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917971134185791}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_14b9e262","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.35"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"FL.35","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.886788845062256}},"branch_attrs":{"mutations":{}}},{"name":"FL.35.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.35.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.35.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.917665958404541}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_879bd6b4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.39"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{"nuc":["G2162A"],"nsp2":["E453K"]},"labels":{"aa":"nsp2: E453K"}},"children":[{"name":"FL.39","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.139145374298096}},"branch_attrs":{"mutations":{}}},{"name":"FL.39.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81109"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.39.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A1378G","T12847C","C13366T","T15096C","C15857T","C17746T","A22995G","C23123T","T27408G"],"S":["K478R","P521S"],"nsp12":["T806I"],"nsp13":["P504S"]},"labels":{"aa":"S: K478R, P521S; nsp12: T806I; nsp13: P504S","spike_mutations":"K478R, P521S"}}}]},{"name":"NODE_0000338","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9744794368743896}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}},"children":[{"name":"FL.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9744794368743896}},"branch_attrs":{"mutations":{}}},{"name":"FL.5.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C2710T","C7039T","T22092C","C27828A"],"ORF7b":["L25I"],"S":["M177T"]},"labels":{"aa":"ORF7b: L25I; S: M177T","spike_mutations":"M177T"}}}]},{"name":"NODE_0000339","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.17"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T3898C","C28333T"],"ORF9b":["P17L"]},"labels":{"aa":"ORF9b: P17L"}},"children":[{"name":"FL.17.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2306T","A2389G","G9087A","A21782C"],"S":["N74H"],"nsp2":["L501F"],"nsp4":["G178D"]},"labels":{"aa":"S: N74H; nsp2: L501F; nsp4: G178D","spike_mutations":"N74H"}}},{"name":"FL.17.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.97144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T22917G","G27703C"],"ORF7a":["V104L"],"S":["L452R"]},"labels":{"aa":"ORF7a: V104L; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.17","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.17"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000340","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.20"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C1912T","A6293G","C9391T","C14016T","G21718C","T22928C","C25714T"],"ORF3a":["L108F"],"S":["Q52H","F456L"],"nsp3":["I1192V"]},"labels":{"aa":"ORF3a: L108F; S: Q52H, F456L; nsp3: I1192V","spike_mutations":"Q52H, F456L"}},"children":[{"name":"FL.20","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"FL.20.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5920999999999998"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["T22926G"],"S":["L455W"]},"labels":{"aa":"S: L455W","spike_mutations":"L455W"}}},{"name":"FL.20.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.20.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.20.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T13C","T19755C","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_10251222","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.21"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{"nuc":["A10564T"]}},"children":[{"name":"FL.21","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.98469352722168}},"branch_attrs":{"mutations":{}}},{"name":"FL.21.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.21.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.793181896209717}},"branch_attrs":{"mutations":{"nuc":["C44T","G24812A"],"S":["D1084N"]},"labels":{"aa":"S: D1084N","spike_mutations":"D1084N"}}},{"name":"FL.21.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.21.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.21.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G3320T","A8884G","C22987A"],"nsp3":["V201F"],"nsp4":["I110M"]},"labels":{"aa":"nsp3: V201F; nsp4: I110M"}}}]},{"name":"internal_8196e6d8","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.10"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{"nuc":["G2235A"],"nsp2":["C477Y"]},"labels":{"aa":"nsp2: C477Y"}},"children":[{"name":"FL.10","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.342740058898926}},"branch_attrs":{"mutations":{}}},{"name":"FL.10.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C4234T","G23222A","T24352C"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"FL.10.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"FL.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.98073"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1216394663867173"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T11422C","G12797A","C17502T","A17612G","C18888T","A22629C","C23130A","G25471A","A27868T","G29392C","C29518A","T29728-","T29729-","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K373N","D415E"],"ORF3a":["D27N"],"ORF7b":["N38I"],"S":["K356T","T523N"],"nsp13":["N459S"],"nsp9":["G38S"]},"labels":{"aa":"N: K373N, D415E; ORF3a: D27N; ORF7b: N38I; S: K356T, T523N; nsp13: N459S; nsp9: G38S","spike_mutations":"K356T, T523N"}}},{"name":"FL.10.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.10.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.930100440979004}},"branch_attrs":{"mutations":{"nuc":["G22103A","T23776C"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}}]},{"name":"internal_267c0772","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.23"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{"nuc":["G16861A"],"nsp13":["V209I"]},"labels":{"aa":"nsp13: V209I"}},"children":[{"name":"FL.23.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C8016T","C8311T","C23185T"],"nsp3":["A1766V"]},"labels":{"aa":"nsp3: A1766V"}}},{"name":"FL.23","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.586221218109131}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000344","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20233T","C21998A","T23042C"],"S":["Q146K","S494P"],"nsp15":["P205S"]},"labels":{"aa":"S: Q146K, S494P; nsp15: P205S","spike_mutations":"Q146K, S494P"}},"children":[{"name":"FL.23.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.23.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.96117"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9782337833287624"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"FL.23.2.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.23.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8835"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9840230566620973"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.23.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1528T","C23123A"],"S":["P521T"]},"labels":{"aa":"S: P521T","spike_mutations":"P521T"}}}]}]},{"name":"NODE_0000345","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{"nuc":["T1753C"]}},"children":[{"name":"FL.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.186100959777832}},"branch_attrs":{"mutations":{}}},{"name":"FL.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.066183090209961}},"branch_attrs":{"mutations":{"nuc":["C7056T"],"nsp3":["T1446I"]},"labels":{"aa":"nsp3: T1446I"}}},{"name":"FL.3.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.156618595123291}},"branch_attrs":{"mutations":{"nuc":["T8830C"]}}},{"name":"FL.3.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2579A","G9257A","C13119T"],"nsp10":["A32V"],"nsp2":["E592K"],"nsp4":["V235I"]},"labels":{"aa":"nsp10: A32V; nsp2: E592K; nsp4: V235I"}}},{"name":"FL.3.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.3.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G10642C","T26232C"]}}}]},{"name":"internal_ebd6af12","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.13"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.282327175140381}},"branch_attrs":{"mutations":{"nuc":["G4354A"]}},"children":[{"name":"FL.13","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.282327175140381}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.47537999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9532427062890917"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C503T","A2611G","C13011T","G22793T"],"S":["A411S"],"nsp1":["P80S"],"nsp9":["T109I"]},"labels":{"aa":"S: A411S; nsp1: P80S; nsp9: T109I","spike_mutations":"A411S"}}},{"name":"FL.13.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.13.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3264T","A3754G","T4507C","C7844A","T21976C","T22928C","C23929T","C27297T"],"S":["F456L"],"nsp3":["T182I","L1709M"]},"labels":{"aa":"S: F456L; nsp3: T182I, L1709M","spike_mutations":"F456L"}}},{"name":"internal_69bba568","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{"nuc":["T6334C","C21904T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"FL.13.2.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.13.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":35},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A3278-","T3279-","T3280-","G3281-","T3282-","T3283-","G3284-","A3285-","G3286-","G3287-","T3288-","T3289-","C3290-","A3291-","A3292-","C3293-","C3294-","T3295-","C3296-","A3297-","A3298-","T3299-","T3300-","A3301-","G3302-","A3303-","G3304-","A3305-","T3306-","G3307-","G3308-","A3309-","A3310-","C3311-","T3312-","T3313-","A3314-","C3315-","A3316-","C3317-","C3318-","A3319-","G3320-","T3321-","T3322-","G3323-","T3324-","T3325-","C3326-","A3327-","G3328-","A3329-","C3330-","T3331-","A3332-","T3333-","T3334-","G3335-","A3336-","A3337-","G3338-","T3339-","G3340-","A3341-","A3342-","T3343-","C7843T","C9870T","G16795T","G22094C"],"S":["D178H"],"nsp13":["V187L"],"nsp3":["I187-","V188-","E189-","V190-","Q191-","P192-","Q193-","L194-","E195-","M196-","E197-","L198-","T199-","P200-","V201-","V202-","Q203-","T204-","I205-","E206-","V207-","N208-"],"nsp4":["T439M"]},"labels":{"aa":"S: D178H; nsp13: V187L; nsp3: I187-, V188-, E189-, V190-, Q191-, P192-, Q193-, L194-, E195-, M196-, E197-, L198-, T199-, P200-, V201-, V202-, Q203-, T204-, I205-, E206-, V207-, N208-; nsp4: T439M","spike_mutations":"D178H"}}},{"name":"FL.13.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.94952917098999}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_566a3ed0","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.13.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T19110C"]}},"children":[{"name":"FL.13.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.13.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.3.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.13.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2969G","G22022C"],"S":["E154Q"],"nsp3":["M84V"]},"labels":{"aa":"S: E154Q; nsp3: M84V","spike_mutations":"E154Q"}}}]},{"name":"internal_10382b90","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.13.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{"nuc":["C44T","C5241T","C12499T","A22106G","T22928C"],"S":["K182E","F456L"],"nsp3":["P841L"]},"labels":{"aa":"S: K182E, F456L; nsp3: P841L","spike_mutations":"K182E, F456L"}},"children":[{"name":"FL.13.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.13.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.653893947601318}},"branch_attrs":{"mutations":{}}},{"name":"FL.13.4.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"FL.13.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07635999999999983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.13.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T3160C","G3994T","G8027C","T11522G","A15489G","A15847T","G21604C","G23012A","C23013A","C28253T"],"S":["Q14H","A484K"],"nsp12":["T803S"],"nsp3":["V1770L"],"nsp6":["F184V"]},"labels":{"aa":"S: Q14H, A484K; nsp12: T803S; nsp3: V1770L; nsp6: F184V","spike_mutations":"Q14H, A484K"}}}]}]},{"name":"internal_59305500","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.9.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.671235084533691}},"branch_attrs":{"mutations":{"nuc":["G2174A","C28846T"],"nsp2":["E457K"]},"labels":{"aa":"nsp2: E457K"}},"children":[{"name":"FL.38","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.38"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A2821G","C14670T","A22995G","T23158C","G23401T","C25482T"],"S":["K478R","Q613H"]},"labels":{"aa":"S: K478R, Q613H","spike_mutations":"K478R, Q613H"}}},{"name":"NODE_0000351","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"FL.15","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.5949530601501465}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000352","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G1464T","C12890T"],"nsp2":["G220V"]},"labels":{"aa":"nsp2: G220V"}},"children":[{"name":"FL.15.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.15.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}}},{"name":"internal_24b5ee08","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.15"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"FL.15.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1684T","C11747T","C29236T"]}}},{"name":"FL.15.4","node_attrs":{"div":103,"Nextclade_pango":{"value":"FL.15.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G6819A"],"nsp3":["S1367N"]},"labels":{"aa":"nsp3: S1367N"}}}]},{"name":"NODE_0000354","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C6285T","G6819A","G22927T"],"S":["L455F"],"nsp3":["T1189I","S1367N"]},"labels":{"aa":"S: L455F; nsp3: T1189I, S1367N","spike_mutations":"L455F"}},"children":[{"name":"FL.15.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000355","node_attrs":{"div":110,"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["C1812G","G1990T","C4438T","G19480A","C22986T"],"S":["A475V"],"nsp14":["G481S"],"nsp2":["A336G","Q395H"]},"labels":{"aa":"S: A475V; nsp14: G481S; nsp2: A336G, Q395H","spike_mutations":"A475V"}},"children":[{"name":"FL.15.1.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"FL.15.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000356","node_attrs":{"div":111,"Nextclade_pango":{"value":"FL.15.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9292C"]}},"children":[{"name":"KF.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"KF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10186T","G22111T"],"S":["E183D"]},"labels":{"aa":"S: E183D","spike_mutations":"E183D"}}},{"name":"KF.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"KF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.15.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G805A","C10782T","C22314A"],"S":["P251H"],"nsp5":["T243I"]},"labels":{"aa":"S: P251H; nsp5: T243I","spike_mutations":"P251H"}}}]}]}]}]}]}]},{"name":"NODE_0000357","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{"nuc":["T4579A"]}},"children":[{"name":"FL.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.839200019836426}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.317378997802734}},"branch_attrs":{"mutations":{"nuc":["C10228T"]}}},{"name":"FL.2.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.4630913734436035}},"branch_attrs":{"mutations":{"nuc":["C21T","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}},{"name":"FL.2.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23485A","C25521T","A29683T"],"S":["N641K"]},"labels":{"aa":"S: N641K","spike_mutations":"N641K"}}},{"name":"FL.2.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.670197010040283}},"branch_attrs":{"mutations":{"nuc":["C22502G"],"S":["Q314E"]},"labels":{"aa":"S: Q314E","spike_mutations":"Q314E"}}},{"name":"internal_fc124546","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{"nuc":["T21988C","A22995G","A29086G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"FL.2.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.28190279006958}},"branch_attrs":{"mutations":{}}},{"name":"FL.2.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.895739555358887}},"branch_attrs":{"mutations":{"nuc":["C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}}]},{"name":"internal_fd8dfcda","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"nsp13":["K460R"]},"labels":{"aa":"nsp13: K460R"}},"children":[{"name":"FL.2.3.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.00936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.11276678947944"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","A11188G","A22629C","C27128T"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"FL.2.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.207553386688232}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e875d4c6","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.7"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{"nuc":["G8117A"],"nsp3":["A1800T"]},"labels":{"aa":"nsp3: A1800T"}},"children":[{"name":"FL.2.7.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.2.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G11417T","A22995G"],"S":["K478R"],"nsp6":["V149F"]},"labels":{"aa":"S: K478R; nsp6: V149F","spike_mutations":"K478R"}}},{"name":"FL.2.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.911281108856201}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000361","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"nsp13":["V169F"]},"labels":{"aa":"nsp13: V169F"}},"children":[{"name":"FL.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"FL.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.9449145793914795}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2416T","C3773T","G25337T","C29274T"],"N":["T334I"],"S":["D1259Y"],"nsp3":["R352C"]},"labels":{"aa":"N: T334I; S: D1259Y; nsp3: R352C","spike_mutations":"D1259Y"}}},{"name":"FL.4.10","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.888331890106201}},"branch_attrs":{"mutations":{"nuc":["G24947A","A29040G"],"N":["K256R"],"S":["V1129I"]},"labels":{"aa":"N: K256R; S: V1129I","spike_mutations":"V1129I"}}},{"name":"FL.4.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.457831382751465}},"branch_attrs":{"mutations":{"nuc":["A22995G","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"internal_13d3b0d2","node_attrs":{"div":98,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.775200128555298}},"branch_attrs":{"mutations":{"nuc":["A28615G"]}},"children":[{"name":"FL.4.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3117T","C5654T","A6211G","C7420T","G22427A","T29602C"],"S":["V289I"],"nsp3":["T133I"]},"labels":{"aa":"S: V289I; nsp3: T133I","spike_mutations":"V289I"}}},{"name":"FL.4.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G7393T","G23858T"],"S":["A766S"]},"labels":{"aa":"S: A766S","spike_mutations":"A766S"}}},{"name":"FL.4.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93509"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C4890T","A22995C","T24544C"],"S":["K478T"],"nsp3":["T724I"]},"labels":{"aa":"S: K478T; nsp3: T724I","spike_mutations":"K478T"}}},{"name":"FL.4.7","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.97144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0536446089490177"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7945T","A19314T","T22917G","T28135C"],"ORF8":["V81A"],"S":["L452R"]},"labels":{"aa":"ORF8: V81A; S: L452R","spike_mutations":"L452R"}}},{"name":"FL.4.9","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C17436T","T22322C","T22327G","A25910G"],"ORF3a":["D173G"],"S":["S254P"]},"labels":{"aa":"ORF3a: D173G; S: S254P","spike_mutations":"S254P"}}},{"name":"internal_12061207","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{"nuc":["A22911T"],"S":["N450I"]},"labels":{"aa":"S: N450I","spike_mutations":"N450I"}},"children":[{"name":"FL.4.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48144"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0186868047371063"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.054556846618652}},"branch_attrs":{"mutations":{}}},{"name":"FL.4.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3348299999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0393497509509053"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T7122C","A22995G"],"S":["K478R"],"nsp3":["I1468T"]},"labels":{"aa":"S: K478R; nsp3: I1468T","spike_mutations":"K478R"}}}]},{"name":"NODE_0000364","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C23635T"]}},"children":[{"name":"FL.4.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.114190578460693}},"branch_attrs":{"mutations":{"nuc":["A3948G","C28093T"],"ORF8":["S67F"],"nsp3":["D410G"]},"labels":{"aa":"ORF8: S67F; nsp3: D410G"}}},{"name":"FL.4.6","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.4.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T5098C","C13965T"]}}}]}]}]},{"name":"internal_291975ea","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{"nuc":["G3242A","C12970T","C23664T"],"S":["A701V"],"nsp3":["G175S"]},"labels":{"aa":"S: A701V; nsp3: G175S","spike_mutations":"A701V"}},"children":[{"name":"FL.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.689967632293701}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C13197T"],"nsp10":["T58I"]},"labels":{"aa":"nsp10: T58I"}}},{"name":"FL.1.3","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C44T","C5907T","G15285T"],"nsp12":["M615I"],"nsp3":["T1063I"]},"labels":{"aa":"nsp12: M615I; nsp3: T1063I"}}},{"name":"FL.1.7","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T6148A","A22995G","A24670G","G25266T","G25696C","G29179C","C29311T"],"ORF3a":["E102Q"],"S":["K478R","C1235F"]},"labels":{"aa":"ORF3a: E102Q; S: K478R, C1235F","spike_mutations":"K478R, C1235F"}}},{"name":"FL.1.8","node_attrs":{"div":107,"Nextclade_pango":{"value":"FL.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78812"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9736469561063519"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C449T","G5917A","C7164T","A13308G","C14877T","A22995G","C23123A","A26544G"],"M":["I8V"],"S":["K478R","P521T"],"nsp1":["P62S"],"nsp10":["K95R"],"nsp3":["T1482I"]},"labels":{"aa":"M: I8V; S: K478R, P521T; nsp1: P62S; nsp10: K95R; nsp3: T1482I","spike_mutations":"K478R, P521T"}}},{"name":"internal_18deba5f","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["A21371C"],"nsp16":["Q238P"]},"labels":{"aa":"nsp16: Q238P"}},"children":[{"name":"FL.1.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"FL.1.1.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"FL.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C8655T","G23624T"],"S":["A688S"],"nsp4":["S34F"]},"labels":{"aa":"S: A688S; nsp4: S34F","spike_mutations":"A688S"}}}]},{"name":"internal_ec0ba103","node_attrs":{"div":100,"Nextclade_pango":{"value":"FL.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G25186T"],"S":["Q1208H"]},"labels":{"aa":"S: Q1208H","spike_mutations":"Q1208H"}},"children":[{"name":"FL.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"FL.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FL.1.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.89211"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9778643306477401"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["C44T","T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]},{"name":"internal_187d562f","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.538186073303223}},"branch_attrs":{"mutations":{"nuc":["T2128C","A21137G","T22928C"],"S":["F456L"],"nsp16":["K160R"]},"labels":{"aa":"S: F456L; nsp16: K160R","spike_mutations":"F456L"}},"children":[{"name":"FL.1.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"FL.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.538186073303223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000369","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.1.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23005A","T23245C","A23604G"],"S":["N481K","H681R"]},"labels":{"aa":"S: N481K, H681R","spike_mutations":"N481K, H681R"}},"children":[{"name":"FL.1.5.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"FL.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.06800999999999986"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T1177C"]}}},{"name":"NODE_0000370","node_attrs":{"div":109,"Nextclade_pango":{"value":"KC.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["C2433T","C12651T","T23030C","C26586T"],"S":["S490P"],"nsp2":["S543F"],"nsp8":["T187I"]},"labels":{"aa":"S: S490P; nsp2: S543F; nsp8: T187I","spike_mutations":"S490P"}},"children":[{"name":"KC.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"KC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.15393000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C5956T","C25120T","G25244C"],"S":["V1228L"]},"labels":{"aa":"S: V1228L","spike_mutations":"V1228L"}}},{"name":"KC.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"KC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.15393000000000004"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1916964954726457"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000371","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{"nuc":["G20060T","A22995G"],"S":["K478R"],"nsp15":["S147I"]},"labels":{"aa":"S: K478R; nsp15: S147I","spike_mutations":"K478R"}},"children":[{"name":"FL.1.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"FL.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.149083137512207}},"branch_attrs":{"mutations":{}}},{"name":"HN.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C703T","A6063C","C18981T"],"nsp3":["D1115A"]},"labels":{"aa":"nsp3: D1115A"}}},{"name":"HN.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"HN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.366540431976318}},"branch_attrs":{"mutations":{"nuc":["G23222A"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"NODE_0000372","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{"nuc":["C1473T","C5986T","G19962T","G28375A"],"ORF9b":["G31E"],"nsp2":["T223I"]},"labels":{"aa":"ORF9b: G31E; nsp2: T223I"}},"children":[{"name":"HN.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.481290817260742}},"branch_attrs":{"mutations":{}}},{"name":"HN.4.2","node_attrs":{"div":112,"Nextclade_pango":{"value":"HN.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T1243C","G21604T","C23347T","C25710T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"NODE_0000373","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.4.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"HN.4.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"HN.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0007299999999998658"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3005141566416802"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C11962T","C14184T","T18012C","T21765C","T22917G","G23222A"],"S":["I68T","L452R","E554K"]},"labels":{"aa":"S: I68T, L452R, E554K","spike_mutations":"I68T, L452R, E554K"}}},{"name":"HN.4.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000374","node_attrs":{"div":105,"Nextclade_pango":{"value":"FL.1.5.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.123271942138672}},"branch_attrs":{"mutations":{"nuc":["C21036T"]}},"children":[{"name":"HN.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["G21761T"],"S":["A67S"]},"labels":{"aa":"S: A67S","spike_mutations":"A67S"}}},{"name":"HN.8","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A6391T","A27477T"],"nsp3":["E1224D"]},"labels":{"aa":"nsp3: E1224D"}}},{"name":"HN.7","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.777099132537842}},"branch_attrs":{"mutations":{"nuc":["C6388T","C20115T"]}}},{"name":"NODE_0000375","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C4345T","C14134T"],"nsp12":["P232S"]},"labels":{"aa":"nsp12: P232S"}},"children":[{"name":"HN.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"HN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{}}},{"name":"HN.2.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T13060G","A24069G"],"S":["Q836R"]},"labels":{"aa":"S: Q836R","spike_mutations":"Q836R"}}}]},{"name":"NODE_0000376","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.3"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{"nuc":["T23042C","G29868-"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"HN.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"HN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.009539999999999936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.963254928588867}},"branch_attrs":{"mutations":{}}},{"name":"HN.3.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"HN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.009539999999999936"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2172876260248378"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.1.1.5.1.3.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G1298T","A22320G"],"S":["D253G"],"nsp2":["G165C"]},"labels":{"aa":"S: D253G; nsp2: G165C","spike_mutations":"D253G"}}}]}]}]}]}]}]},{"name":"NODE_0000377","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.619708299636841}},"branch_attrs":{"mutations":{"nuc":["T44C","A16878T","T23018C","A27507C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"EG.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.11"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.852965354919434}},"branch_attrs":{"mutations":{"nuc":["C44T","G19326A","G23222A","A26319G"],"S":["E554K"]},"labels":{"aa":"S: E554K","spike_mutations":"E554K"}}},{"name":"EG.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.12"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C12741T","C21998A","G23222A","C25511T","G28857C"],"N":["R195T"],"ORF3a":["S40L"],"S":["Q146K","E554K"],"nsp9":["T19I"]},"labels":{"aa":"N: R195T; ORF3a: S40L; S: Q146K, E554K; nsp9: T19I","spike_mutations":"Q146K, E554K"}}},{"name":"EG.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.13"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.175896644592285}},"branch_attrs":{"mutations":{"nuc":["G1T","G2659T","C8752T"],"nsp2":["K618N"]},"labels":{"aa":"nsp2: K618N"}}},{"name":"EG.14","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.14"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["A17615G","C20016T","C25553T"],"ORF3a":["A54V"],"nsp13":["K460R"]},"labels":{"aa":"ORF3a: A54V; nsp13: K460R"}}},{"name":"EG.7","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1186099999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0727745250647887"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A6022G","A7857G","C8818T","C18452T","G22770A","C23099T","-29759G"],"S":["R403K","L513F"],"nsp14":["A138V"],"nsp3":["N1713S"]},"labels":{"aa":"S: R403K, L513F; nsp14: A138V; nsp3: N1713S","spike_mutations":"R403K, L513F"}}},{"name":"EG.8","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.961877822875977}},"branch_attrs":{"mutations":{"nuc":["C21T","C7173T","-29759G"],"nsp3":["S1485F"]},"labels":{"aa":"nsp3: S1485F"}}},{"name":"XBB.1.9.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"XBB.1.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.619708299636841}},"branch_attrs":{"mutations":{"nuc":["-29759G"]}}},{"name":"internal_d6c86d9f","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.9"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4686T","A16373G","G22770A","C29347T"],"S":["R403K"],"nsp13":["N46S"],"nsp3":["T656I"]},"labels":{"aa":"S: R403K; nsp13: N46S; nsp3: T656I","spike_mutations":"R403K"}},"children":[{"name":"EG.9","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.20938"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C22593T","T24979C","A29125G"],"S":["A344V"]},"labels":{"aa":"S: A344V","spike_mutations":"A344V"}}},{"name":"EG.9.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17686"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.9.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C13767T","G22592A"],"S":["A344T"]},"labels":{"aa":"S: A344T","spike_mutations":"A344T"}}}]},{"name":"internal_16d15670","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.10"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G22592A","G22770A"],"S":["A344T","R403K"]},"labels":{"aa":"S: A344T, R403K","spike_mutations":"A344T, R403K"}},"children":[{"name":"EG.10","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17686"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0861679898367071"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.409616947174072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000380","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.10.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C335T","T16548G","G21255T","T23042C","C23664T"],"S":["S494P","A701V"],"nsp1":["R24C"]},"labels":{"aa":"S: S494P, A701V; nsp1: R24C","spike_mutations":"S494P, A701V"}},"children":[{"name":"EG.10.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1256300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T8482C","T16251C","C28399T"],"ORF9b":["P39L"]},"labels":{"aa":"ORF9b: P39L"}}},{"name":"EG.10.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.10.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1256300000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1167095912810734"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.10.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0006818771362305}},"branch_attrs":{"mutations":{"nuc":["G8372T","G11312A","C18175T"],"nsp14":["P46S"],"nsp3":["V1885L"],"nsp6":["V114I"]},"labels":{"aa":"nsp14: P46S; nsp3: V1885L; nsp6: V114I"}}}]}]},{"name":"internal_dee45864","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.6"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}},"children":[{"name":"EG.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.965919494628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000382","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.6.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{"nuc":["C17766T","T22928C","T27346C"],"ORF6":["Y49H"],"S":["F456L"]},"labels":{"aa":"ORF6: Y49H; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"EG.6.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.884516716003418}},"branch_attrs":{"mutations":{}}},{"name":"EG.6.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.6.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C18570T","G23675A"],"S":["V705I"]},"labels":{"aa":"S: V705I","spike_mutations":"V705I"}}},{"name":"EG.6.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.6.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07635999999999983"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2298667334498823"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.6.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5622T","G18194A","C22286A","G23012A","C23013A","C27881T"],"S":["L242I","A484K"],"nsp14":["R52K"],"nsp3":["P968L"]},"labels":{"aa":"S: L242I, A484K; nsp14: R52K; nsp3: P968L","spike_mutations":"L242I, A484K"}}}]}]},{"name":"NODE_0000383","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["C44T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}},"children":[{"name":"EG.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089593410491943}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"EG.2.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2370T","A6355T","C9430T","T18471C","A22474T","G28884C"],"N":["R204P"],"S":["K304N"],"nsp2":["A522V"]},"labels":{"aa":"N: R204P; S: K304N; nsp2: A522V","spike_mutations":"K304N"}}},{"name":"EG.2.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C36T","A1230G","A17344G","A23786G"],"S":["I742V"],"nsp13":["I370V"],"nsp2":["K142R"]},"labels":{"aa":"S: I742V; nsp13: I370V; nsp2: K142R","spike_mutations":"I742V"}}},{"name":"EG.2.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.86275"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1352521981201698"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G7059A","C8818T","T19929C","C21549T","A22629C","C25521T","T27522C"],"S":["K356T"],"nsp3":["G1447D"]},"labels":{"aa":"S: K356T; nsp3: G1447D","spike_mutations":"K356T"}}},{"name":"EG.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.041689999999999984"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1863788114390663"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T5165C","C5365T","C9133T","G18332T","C19032T","G22541A","C22663T","T22930A","A26120G","C27389T"],"ORF3a":["H243R"],"S":["V327I","F456L"],"nsp14":["R98I"],"nsp3":["Y816H"]},"labels":{"aa":"ORF3a: H243R; S: V327I, F456L; nsp14: R98I; nsp3: Y816H","spike_mutations":"V327I, F456L"}}},{"name":"EG.2.5","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G4561A","G23587C","C24748T"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"internal_57ebb6f5","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{"nuc":["C28651T"]}},"children":[{"name":"EG.4.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A24170G","G28628T"],"N":["A119S"],"S":["I870V"]},"labels":{"aa":"N: A119S; S: I870V","spike_mutations":"I870V"}}},{"name":"EG.4.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G23401C","G25471C"],"ORF3a":["D27H"],"S":["Q613H"]},"labels":{"aa":"ORF3a: D27H; S: Q613H","spike_mutations":"Q613H"}}},{"name":"EG.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"EG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.318837642669678}},"branch_attrs":{"mutations":{}}},{"name":"EG.4.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T14652C","C23430T","G26199A"],"S":["A623V"]},"labels":{"aa":"S: A623V","spike_mutations":"A623V"}}},{"name":"EG.4.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A4659G","C11095T","C16084T"],"nsp12":["H882Y"],"nsp3":["Y647C"]},"labels":{"aa":"nsp12: H882Y; nsp3: Y647C"}}},{"name":"EG.4.5","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8657900000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9677241877751146"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.4.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_132d0df5","node_attrs":{"div":98,"Nextclade_pango":{"value":"XBB.1.9.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C28928T"],"N":["L219F"]},"labels":{"aa":"N: L219F"}},"children":[{"name":"EG.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C8597T","-29759G"],"nsp4":["L15F"]},"labels":{"aa":"nsp4: L15F"}}},{"name":"NODE_0000386","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.1"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EG.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.5413897037506104}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1473T","G21770T","A22496G"],"S":["V70F","I312V"],"nsp2":["T223I"]},"labels":{"aa":"S: V70F, I312V; nsp2: T223I","spike_mutations":"V70F, I312V"}}},{"name":"EG.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.089168548583984}},"branch_attrs":{"mutations":{"nuc":["C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}}},{"name":"EG.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"EG.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.0570220947265625}},"branch_attrs":{"mutations":{"nuc":["C3784T","A6613G"]}}},{"name":"EG.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.570929527282715}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"EG.1.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.7"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.121777057647705}},"branch_attrs":{"mutations":{"nuc":["A22029T"],"S":["E156V"]},"labels":{"aa":"S: E156V","spike_mutations":"E156V"}}},{"name":"EG.1.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.6"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-3.8094167709350586}},"branch_attrs":{"mutations":{"nuc":["G26235T"]}}},{"name":"EG.1.8","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.8"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["G11842A","A13949G","C20429T","T21201C","C23481T","C27804T"],"S":["S640F"],"nsp12":["D170G"],"nsp15":["P270L"]},"labels":{"aa":"S: S640F; nsp12: D170G; nsp15: P270L","spike_mutations":"S640F"}}},{"name":"internal_e85bc240","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.4"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{"nuc":["C7764T"],"nsp3":["S1682F"]},"labels":{"aa":"nsp3: S1682F"}},"children":[{"name":"EG.1.4","node_attrs":{"div":100,"Nextclade_pango":{"value":"EG.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.400798320770264}},"branch_attrs":{"mutations":{}}},{"name":"EG.1.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0124"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9484139900167534"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.1.4.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C1528T","C6027T","G7100A","T16062G","C22212T","T25732G","C25989A"],"ORF3a":["F114V","D199E"],"S":["P217L"],"nsp12":["N874K"],"nsp3":["P1103L","A1461T"]},"labels":{"aa":"ORF3a: F114V, D199E; S: P217L; nsp12: N874K; nsp3: P1103L, A1461T","spike_mutations":"P217L"}}}]}]}]},{"name":"internal_a4de9cf4","node_attrs":{"div":102,"Nextclade_pango":{"value":"EG.5"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.697697162628174}},"branch_attrs":{"mutations":{"nuc":["C2334T","C9693T","C22480T","T22930A","C29625T"],"ORF10":["S23F"],"S":["F456L"],"nsp2":["A510V"],"nsp4":["A380V"]},"labels":{"aa":"ORF10: S23F; S: F456L; nsp2: A510V; nsp4: A380V","spike_mutations":"F456L"}},"children":[{"name":"EG.5","node_attrs":{"div":103,"Nextclade_pango":{"value":"EG.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C23481T"],"S":["S640F"]},"labels":{"aa":"S: S640F","spike_mutations":"S640F"}}},{"name":"NODE_0000389","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{"nuc":["T5152C","C28754T"],"N":["L161F"]},"labels":{"aa":"N: L161F"}},"children":[{"name":"EG.5.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.303452491760254}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.2.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.3"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C23673T","A25094G"],"S":["S704L","N1178D"]},"labels":{"aa":"S: S704L, N1178D","spike_mutations":"S704L, N1178D"}}},{"name":"EG.5.2.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C8290T","C12781T","C14183T"],"nsp12":["T248I"]},"labels":{"aa":"nsp12: T248I"}}},{"name":"NODE_0000390","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.2"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.038470268249512}},"branch_attrs":{"mutations":{"nuc":["C3602T","A6729G","C11518T","A25744G"],"ORF3a":["I118V"],"nsp3":["H295Y","N1337S"]},"labels":{"aa":"ORF3a: I118V; nsp3: H295Y, N1337S"}},"children":[{"name":"EG.5.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.5.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.1"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["C832T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"EG.5.2.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"EG.5.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23D (XBB.1.9)"},"partiallyAliased":{"value":"XBB.1.9.2.5.2.4"},"clade_nextstrain":{"value":"23D"},"clade_membership":{"value":"23D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]}]},{"name":"NODE_0000391","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.3748607635498047}},"branch_attrs":{"mutations":{"nuc":["A18492G","G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","clade":"23F","spike_mutations":"Q52H"}},"children":[{"name":"EG.5.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"EG.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.3748607635498047}},"branch_attrs":{"mutations":{}}},{"name":"EG.5.1.13","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.772064685821533}},"branch_attrs":{"mutations":{"nuc":["C12439T"]}}},{"name":"EG.5.1.12","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.12"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.292908668518066}},"branch_attrs":{"mutations":{"nuc":["T26972C","C28909T"]}}},{"name":"EG.5.1.10","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.10"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.850919246673584}},"branch_attrs":{"mutations":{"nuc":["C3622T","A11537G"],"nsp6":["I189V"]},"labels":{"aa":"nsp6: I189V"}}},{"name":"EG.5.1.15","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.15"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.343207836151123}},"branch_attrs":{"mutations":{"nuc":["C2523T"],"nsp2":["T573I"]},"labels":{"aa":"nsp2: T573I"}}},{"name":"EG.5.1.17","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.17"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.621212005615234}},"branch_attrs":{"mutations":{"nuc":["G22927C","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"EG.5.1.16","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.16"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.816084146499634}},"branch_attrs":{"mutations":{"nuc":["C20759T"],"nsp16":["A34V"]},"labels":{"aa":"nsp16: A34V"}}},{"name":"EG.5.1.14","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.14"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C16017T","C19524T"]}}},{"name":"EG.5.1.2","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["C44T","G18397A"],"nsp14":["V120I"]},"labels":{"aa":"nsp14: V120I"}}},{"name":"EG.5.1.19","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.19"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.5858540534973145}},"branch_attrs":{"mutations":{"nuc":["T26171A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"EG.5.1.18","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.18"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.37448787689209}},"branch_attrs":{"mutations":{"nuc":["G9269A","G26051T"],"ORF3a":["S220I"],"nsp4":["G239S"]},"labels":{"aa":"ORF3a: S220I; nsp4: G239S"}}},{"name":"EG.5.1.7","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.3128533363342285}},"branch_attrs":{"mutations":{"nuc":["A22396T"],"S":["K278N"]},"labels":{"aa":"S: K278N","spike_mutations":"K278N"}}},{"name":"EG.5.1.5","node_attrs":{"div":110,"Nextclade_pango":{"value":"EG.5.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C44T","G199A","C10142A","C17288T","T20512G","C29870A"],"nsp13":["T351I"],"nsp15":["L298V"],"nsp5":["L30I"]},"labels":{"aa":"nsp13: T351I; nsp15: L298V; nsp5: L30I"}}},{"name":"EG.5.1.9","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.405920505523682}},"branch_attrs":{"mutations":{"nuc":["A3210G","C8947T","C22088T","C29774T"],"S":["L176F"],"nsp3":["D164G"]},"labels":{"aa":"S: L176F; nsp3: D164G","spike_mutations":"L176F"}}},{"name":"internal_d30fa253","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.4"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}},"children":[{"name":"EG.5.1.4","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7202579975128174}},"branch_attrs":{"mutations":{}}},{"name":"JJ.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"JJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.4.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.377831935882568}},"branch_attrs":{"mutations":{"nuc":["C44T","G22927T","A25531G","C26111T"],"ORF3a":["I47V","P240L"],"S":["L455F"]},"labels":{"aa":"ORF3a: I47V, P240L; S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_356adb2d","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.11"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{"nuc":["A22106C"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}},"children":[{"name":"EG.5.1.11","node_attrs":{"div":105,"Nextclade_pango":{"value":"EG.5.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.10234260559082}},"branch_attrs":{"mutations":{}}},{"name":"internal_a3af6ee5","node_attrs":{"div":106,"Nextclade_pango":{"value":"JR.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A25664G"],"ORF3a":["Y91C"]},"labels":{"aa":"ORF3a: Y91C"}},"children":[{"name":"JR.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"JR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.477802753448486}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000395","node_attrs":{"div":111,"Nextclade_pango":{"value":"JR.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C1613T","G20995T","G22927C","A22995G","A27388C"],"S":["L455F","K478R"],"nsp16":["G113C"],"nsp2":["L270F"]},"labels":{"aa":"S: L455F, K478R; nsp16: G113C; nsp2: L270F","spike_mutations":"L455F, K478R"}},"children":[{"name":"JR.1.1.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"JR.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.73257"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4312755323086508"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C9447T","A22628C"],"S":["K356Q"],"nsp4":["A298V"]},"labels":{"aa":"S: K356Q; nsp4: A298V","spike_mutations":"K356Q"}}},{"name":"JR.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"JR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.11.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0000396","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{"nuc":["G22927T","C29762T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"EG.5.1.8","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.45935583114624}},"branch_attrs":{"mutations":{}}},{"name":"KB.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"KB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G10900A","A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"internal_b60a1521","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.8676750659942627}},"branch_attrs":{"mutations":{"nuc":["C12100G"]}},"children":[{"name":"KB.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C14676A","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"KB.4","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["C44T","C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"KB.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"KB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.8.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G21809A","C27603T"],"S":["A83T"]},"labels":{"aa":"S: A83T","spike_mutations":"A83T"}}}]}]},{"name":"NODE_0000398","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.3"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{"nuc":["C1889T","C22570T"],"nsp2":["R362C"]},"labels":{"aa":"nsp2: R362C"}},"children":[{"name":"EG.5.1.3","node_attrs":{"div":106,"Nextclade_pango":{"value":"EG.5.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.35067081451416}},"branch_attrs":{"mutations":{}}},{"name":"JG.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.504892349243164}},"branch_attrs":{"mutations":{"nuc":["C23757T"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"JG.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.471979141235352}},"branch_attrs":{"mutations":{"nuc":["G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"JG.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"JG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.575511932373047}},"branch_attrs":{"mutations":{"nuc":["C1684T"]}}},{"name":"NODE_0000399","node_attrs":{"div":109,"Nextclade_pango":{"value":"JG.3"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{"nuc":["C7086T","G22927T","C23673T"],"S":["L455F","S704L"],"nsp3":["T1456I"]},"labels":{"aa":"S: L455F, S704L; nsp3: T1456I","spike_mutations":"L455F, S704L"}},"children":[{"name":"JG.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"JG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.5658464431762695}},"branch_attrs":{"mutations":{}}},{"name":"JG.3.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"JG.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.9912307262420654}},"branch_attrs":{"mutations":{"nuc":["C7932T","C22482T","C25810T"],"ORF3a":["L140F"],"S":["T307I"],"nsp3":["S1738L"]},"labels":{"aa":"ORF3a: L140F; S: T307I; nsp3: S1738L","spike_mutations":"T307I"}}},{"name":"JG.3.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"JG.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.4253100000000001"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2837475542379917"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.8458521366119385}},"branch_attrs":{"mutations":{"nuc":["C44T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"JG.3.3","node_attrs":{"div":111,"Nextclade_pango":{"value":"JG.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.833364009857178}},"branch_attrs":{"mutations":{"nuc":["C44T","G21809T"],"S":["A83S"]},"labels":{"aa":"S: A83S","spike_mutations":"A83S"}}},{"name":"JG.3.4","node_attrs":{"div":112,"Nextclade_pango":{"value":"JG.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.5133399999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.216901623730935"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.3.3.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.12369441986084}},"branch_attrs":{"mutations":{"nuc":["C44T","C2462T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]}]},{"name":"NODE_0000400","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.735776662826538}},"branch_attrs":{"mutations":{"nuc":["C44T","C5835T","C22033A"],"S":["F157L"],"nsp3":["S1039L"]},"labels":{"aa":"S: F157L; nsp3: S1039L","spike_mutations":"F157L"}},"children":[{"name":"EG.5.1.6","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.735776662826538}},"branch_attrs":{"mutations":{}}},{"name":"HV.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"HV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["T44C","C925T","G14559A","C14919A","G22927T","C27161T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"NODE_0000401","node_attrs":{"div":109,"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.068493127822876}},"branch_attrs":{"mutations":{"nuc":["T22917G","C29784T"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"HV.1.10","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.025979999999999802"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.10"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85975456237793}},"branch_attrs":{"mutations":{"nuc":["C15720T","C22916T"],"S":["R452W"]},"labels":{"aa":"S: R452W","spike_mutations":"R452W"}}},{"name":"HV.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.068493127822876}},"branch_attrs":{"mutations":{}}},{"name":"HV.1.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"HV.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21974"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3005451981781486"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.3"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A23040T"],"S":["Q493L"]},"labels":{"aa":"S: Q493L","spike_mutations":"Q493L"}}},{"name":"HV.1.11","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.0887599999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3341105633249508"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.31048583984375}},"branch_attrs":{"mutations":{"nuc":["C21952T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"HV.1.5","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.40152645111084}},"branch_attrs":{"mutations":{"nuc":["C1912T","C25355T"],"S":["L1265F"]},"labels":{"aa":"S: L1265F","spike_mutations":"L1265F"}}},{"name":"HV.1.4","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297389984130859}},"branch_attrs":{"mutations":{"nuc":["G24794T","C27945T"],"ORF8":["Q18*"],"S":["A1078S"]},"labels":{"aa":"ORF8: Q18*; S: A1078S","spike_mutations":"A1078S"}}},{"name":"HV.1.7","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T6682C","C22224T","T23198C"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}},{"name":"HV.1.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"HV.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.875742435455322}},"branch_attrs":{"mutations":{"nuc":["C346T","A22194T","C22624T","C24912T"],"S":["N211I","T1117I"]},"labels":{"aa":"S: N211I, T1117I","spike_mutations":"N211I, T1117I"}}},{"name":"HV.1.8","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C1093T","C1302T","C22185T"],"S":["T208M"],"nsp2":["T166I"]},"labels":{"aa":"S: T208M; nsp2: T166I","spike_mutations":"T208M"}}},{"name":"internal_2378868c","node_attrs":{"div":110,"Nextclade_pango":{"value":"HV.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.043657064437866}},"branch_attrs":{"mutations":{"nuc":["C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}},"children":[{"name":"HV.1.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.38161000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3552393372267753"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.412596702575684}},"branch_attrs":{"mutations":{"nuc":["C23103T"],"S":["S514F"]},"labels":{"aa":"S: S514F","spike_mutations":"S514F"}}},{"name":"HV.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.048559999999999943"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.85923171043396}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}}}]},{"name":"NODE_0000403","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.6"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["C5646T","C6317T","C26885T"],"nsp3":["T976I","P1200S"]},"labels":{"aa":"nsp3: T976I, P1200S"}},"children":[{"name":"HV.1.6","node_attrs":{"div":112,"Nextclade_pango":{"value":"HV.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000404","node_attrs":{"div":114,"Nextclade_pango":{"value":"HV.1.6.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C11020T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"HV.1.6.1","node_attrs":{"div":114,"Nextclade_pango":{"value":"HV.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000405","node_attrs":{"div":115,"Nextclade_pango":{"value":"KL.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"KL.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"KL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.008039999999999839"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"KL.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"KL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.008039999999999839"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3830518742909887"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.6.1.6.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G19101T","C24863T","T25510C"],"ORF3a":["S40P"],"S":["H1101Y"],"nsp14":["Q354H"]},"labels":{"aa":"ORF3a: S40P; S: H1101Y; nsp14: Q354H","spike_mutations":"H1101Y"}}}]}]}]}]}]},{"name":"NODE_0000406","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{"nuc":["C6541T","G13627A","C25572T"],"nsp12":["D63N"]},"labels":{"aa":"nsp12: D63N"}},"children":[{"name":"EG.5.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"EG.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.172736167907715}},"branch_attrs":{"mutations":{}}},{"name":"HK.12","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.12"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.363696575164795}},"branch_attrs":{"mutations":{"nuc":["C44T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.17","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.13706999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1972306507819483"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.17"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.282658100128174}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"HK.18","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.14733999999999992"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2787222677331491"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.18"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.191495895385742}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28292A"],"N":["Q7K"],"S":["L452R"]},"labels":{"aa":"N: Q7K; S: L452R","spike_mutations":"L452R"}}},{"name":"HK.19","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.19"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.508697986602783}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.21","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.1481699999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.205901853206978"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.21"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C20016T","C22971A","T23948C"],"S":["T470N","Y796H"]},"labels":{"aa":"S: T470N, Y796H","spike_mutations":"T470N, Y796H"}}},{"name":"HK.22","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.49366"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.310148541751831"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.22"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C2662T","T2698C","A3019G","T15408C","G18332A","T22917A","G22927T","T24709C","G25407T"],"ORF3a":["M5I"],"S":["L452Q","L455F"],"nsp14":["R98K"]},"labels":{"aa":"ORF3a: M5I; S: L452Q, L455F; nsp14: R98K","spike_mutations":"L452Q, L455F"}}},{"name":"HK.25","node_attrs":{"div":125,"Nextclade_pango":{"value":"HK.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.25"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T499A","C1191T","T2633C","C3686T","C4093A","A6601C","G11516T","C13019T","A22629C","A23604G","G25606T","C26534T","A27107C","C27600T","T28251G","C28253T","A28254C","C29367T"],"N":["P365L"],"ORF3a":["A72S"],"ORF8":["F120V","I121L"],"S":["K356T","H681R"],"nsp2":["P129L"],"nsp3":["H323Y","E1294D"],"nsp6":["V182F"]},"labels":{"aa":"N: P365L; ORF3a: A72S; ORF8: F120V, I121L; S: K356T, H681R; nsp2: P129L; nsp3: H323Y, E1294D; nsp6: V182F","spike_mutations":"K356T, H681R"}}},{"name":"HK.28","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.28"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.039299964904785}},"branch_attrs":{"mutations":{"nuc":["C19170T"]}}},{"name":"HK.29","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.29"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.267587184906006}},"branch_attrs":{"mutations":{"nuc":["G7791A"],"nsp3":["G1691D"]},"labels":{"aa":"nsp3: G1691D"}}},{"name":"HK.31","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.31"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.251417636871338}},"branch_attrs":{"mutations":{"nuc":["G2075A"],"nsp2":["G424S"]},"labels":{"aa":"nsp2: G424S"}}},{"name":"HK.32","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.32"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.621038913726807}},"branch_attrs":{"mutations":{"nuc":["A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.30","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.30"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.052764892578125}},"branch_attrs":{"mutations":{"nuc":["T26609C"]}}},{"name":"HK.4","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.4"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.861818790435791}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"HK.5","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.5"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.248337268829346}},"branch_attrs":{"mutations":{"nuc":["G23593C"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"HK.7","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.7"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8021769523620605}},"branch_attrs":{"mutations":{"nuc":["A22005C"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"internal_41ab7e5c","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{"nuc":["G22332T"],"S":["G257V"]},"labels":{"aa":"S: G257V","spike_mutations":"G257V"}},"children":[{"name":"HK.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.226341247558594}},"branch_attrs":{"mutations":{}}},{"name":"HK.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C44T","G6320A","C11704T","C22482T","G22927C"],"S":["T307I","L455F"],"nsp3":["V1201I"]},"labels":{"aa":"S: T307I, L455F; nsp3: V1201I","spike_mutations":"T307I, L455F"}}}]},{"name":"internal_2e7b44ef","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.11"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{"nuc":["C44T","G22112A"],"S":["G184S"]},"labels":{"aa":"S: G184S","spike_mutations":"G184S"}},"children":[{"name":"HK.11","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.8122663497924805}},"branch_attrs":{"mutations":{}}},{"name":"HK.11.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.11.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["T4789A","T13228C","G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_ce3ef6fb","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.2"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{"nuc":["C44T","G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}},"children":[{"name":"HK.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.561142921447754}},"branch_attrs":{"mutations":{}}},{"name":"HK.2.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.2.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.264484405517578}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_78bcc78c","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.20"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","C6695T","C9448A","G22927T"],"S":["L455F"],"nsp3":["P1326S"]},"labels":{"aa":"S: L455F; nsp3: P1326S","spike_mutations":"L455F"}},"children":[{"name":"HK.20","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-6.294872283935547}},"branch_attrs":{"mutations":{}}},{"name":"HK.20.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.6088199999999999"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2183176254438959"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.20.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["G23006C"],"S":["G482R"]},"labels":{"aa":"S: G482R","spike_mutations":"G482R"}}}]},{"name":"internal_1ede7aef","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.24"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{"nuc":["C44T","G23522A"],"S":["E654K"]},"labels":{"aa":"S: E654K","spike_mutations":"E654K"}},"children":[{"name":"HK.24","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.345410346984863}},"branch_attrs":{"mutations":{}}},{"name":"HK.24.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.24.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.814077377319336}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}}]},{"name":"internal_656de736","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.23"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"HK.23","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.00276517868042}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000413","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.23.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["C8982A","C16887T","T19710C","G22927T","C27213T"],"S":["L455F"],"nsp4":["T143N"]},"labels":{"aa":"S: L455F; nsp4: T143N","spike_mutations":"L455F"}},"children":[{"name":"HK.23.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"HK.23.1.1","node_attrs":{"div":119,"Nextclade_pango":{"value":"HK.23.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.48614000000000007"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3534097328298118"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.23.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G1067T","A1290G","G1661A","G20057A","G22604T"],"S":["A348S"],"nsp15":["G146D"],"nsp2":["G88W","E162G","D286N"]},"labels":{"aa":"S: A348S; nsp15: G146D; nsp2: G88W, E162G, D286N","spike_mutations":"A348S"}}}]}]},{"name":"internal_06b86205","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.950725555419922}},"branch_attrs":{"mutations":{"nuc":["T14988C"]}},"children":[{"name":"HK.6","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.6"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.7662484645843506}},"branch_attrs":{"mutations":{"nuc":["G6032A","A22320G","A23014T"],"S":["D253G"],"nsp3":["A1105T"]},"labels":{"aa":"S: D253G; nsp3: A1105T","spike_mutations":"D253G"}}},{"name":"internal_01437a73","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.26"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{"nuc":["G22927T","C25546A"],"ORF3a":["L52I"],"S":["L455F"]},"labels":{"aa":"ORF3a: L52I; S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.26","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.297348976135254}},"branch_attrs":{"mutations":{}}},{"name":"HK.26.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.26.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.919094562530518}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]}]},{"name":"internal_188bb1dd","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.27"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["C44T","C5031T"],"nsp3":["T771I"]},"labels":{"aa":"nsp3: T771I"}},"children":[{"name":"HK.27","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000417","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.27.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.27.1","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.27.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.442716121673584}},"branch_attrs":{"mutations":{}}},{"name":"HK.27.1.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.27.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.27.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.570084571838379}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]}]},{"name":"internal_ec31cc5d","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.634453296661377}},"branch_attrs":{"mutations":{"nuc":["C2644T"]}},"children":[{"name":"HK.33","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.33"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.897692680358887}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"internal_04291e2c","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.34"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","C3457T","G11243A","T16383A","T22119C","C25614T"],"S":["F186S"],"nsp6":["V91M"]},"labels":{"aa":"S: F186S; nsp6: V91M","spike_mutations":"F186S"}},"children":[{"name":"HK.34.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18525999999999987"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3709381401972789"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C207T","C19011T","A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}}},{"name":"HK.34","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.34"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}}]}]},{"name":"internal_9bba602f","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.13"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{"nuc":["G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.13.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.202107906341553}},"branch_attrs":{"mutations":{"nuc":["C44T","C13378T","A24604G"]}}},{"name":"HK.13","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.2135725021362305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000421","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.13.2"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C6016T","T23953A","G25019C"],"S":["F797L","D1153H"]},"labels":{"aa":"S: F797L, D1153H","spike_mutations":"F797L, D1153H"}},"children":[{"name":"HK.13.2","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"HK.13.2.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"HK.13.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.13.2.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C13335T","A16999G","C22311T","C29409T"],"N":["T379I"],"S":["T250I"],"nsp10":["A104V"],"nsp13":["T255A"]},"labels":{"aa":"N: T379I; S: T250I; nsp10: A104V; nsp13: T255A","spike_mutations":"T250I"}}}]}]},{"name":"internal_eea7306c","node_attrs":{"div":108,"Nextclade_pango":{"value":"EG.5.1.1"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-3.680764675140381}},"branch_attrs":{"mutations":{"nuc":["C11779T"]}},"children":[{"name":"HK.14","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.14"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C6781T","C17802T","G22927C"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}}},{"name":"HK.15","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.15"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3237G","G22346A"],"S":["A262T"],"nsp3":["Q173R"]},"labels":{"aa":"S: A262T; nsp3: Q173R","spike_mutations":"A262T"}}},{"name":"HK.16","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.16"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-5.089319229125977}},"branch_attrs":{"mutations":{"nuc":["T22654C","C23613T","G25352T","C28472T"],"N":["P67S"],"S":["A684V","V1264L"]},"labels":{"aa":"N: P67S; S: A684V, V1264L","spike_mutations":"A684V, V1264L"}}},{"name":"HK.9","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18829999999999997"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1663965021068448"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.9"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C15720T","G22131A"],"S":["R190K"]},"labels":{"aa":"S: R190K","spike_mutations":"R190K"}}},{"name":"internal_57386ce8","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.8"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","spike_mutations":"L455F"}},"children":[{"name":"HK.8","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.825417995452881}},"branch_attrs":{"mutations":{}}},{"name":"HK.8.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23F (EG.5.1)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.8.1"},"clade_nextstrain":{"value":"23F"},"clade_membership":{"value":"23F"},"placement_prior":{"value":-4.648499011993408}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25904T"],"ORF3a":["S171L"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: S171L; S: D1153Y","spike_mutations":"D1153Y"}}}]}]},{"name":"internal_HK.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.3"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{"nuc":["G22927T"],"S":["L455F"]},"labels":{"aa":"S: L455F","clade":"23H","spike_mutations":"L455F"}},"children":[{"name":"HK.3.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"HK.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.1"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.9346041679382324}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"HK.3","node_attrs":{"div":108,"Nextclade_pango":{"value":"HK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.1366171836853027}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.12","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.12"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C10834T","G23624A","G29781T"],"S":["A688T"]},"labels":{"aa":"S: A688T","spike_mutations":"A688T"}}},{"name":"HK.3.10","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.10"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T18351C","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"HK.3.11","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.11"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C2395T","C12415T","C17397A","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"HK.3.13","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.13"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.741406440734863}},"branch_attrs":{"mutations":{"nuc":["T221C","C14889T","A21603G"],"S":["Q14R"]},"labels":{"aa":"S: Q14R","spike_mutations":"Q14R"}}},{"name":"HK.3.14","node_attrs":{"div":112,"Nextclade_pango":{"value":"HK.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.0860600000000002"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.2622098838280695"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.14"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.819791316986084}},"branch_attrs":{"mutations":{"nuc":["C44T","T20600C","C22986T","C29762T"],"S":["A475V"],"nsp15":["I327T"]},"labels":{"aa":"S: A475V; nsp15: I327T","spike_mutations":"A475V"}}},{"name":"HK.3.3","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.3"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.372292518615723}},"branch_attrs":{"mutations":{"nuc":["C44T","C22329T","C29364T"],"N":["P364L"],"S":["S256L"]},"labels":{"aa":"N: P364L; S: S256L","spike_mutations":"S256L"}}},{"name":"HK.3.4","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.4"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C934T","C1284T","T13324C","C23987T","C27630T"],"S":["P809S"],"nsp2":["T160I"]},"labels":{"aa":"S: P809S; nsp2: T160I","spike_mutations":"P809S"}}},{"name":"HK.3.5","node_attrs":{"div":114,"Nextclade_pango":{"value":"HK.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.5"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C44T","G3893A","C11008T","T18324C","C22082T","C27889T"],"S":["P174S"],"nsp3":["E392K"]},"labels":{"aa":"S: P174S; nsp3: E392K","spike_mutations":"P174S"}}},{"name":"HK.3.7","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.7"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.629085540771484}},"branch_attrs":{"mutations":{"nuc":["C44T","G22073A"],"S":["V171I"]},"labels":{"aa":"S: V171I","spike_mutations":"V171I"}}},{"name":"HK.3.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"HK.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.9"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.312388896942139}},"branch_attrs":{"mutations":{"nuc":["C44T","T22849C","C23757T","A28877T","G28878C"],"S":["T732I"]},"labels":{"aa":"S: T732I","spike_mutations":"T732I"}}},{"name":"HK.3.6","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.6"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4345T","T8870C","G22103A"],"S":["G181R"]},"labels":{"aa":"S: G181R","spike_mutations":"G181R"}}},{"name":"HK.3.8","node_attrs":{"div":110,"Nextclade_pango":{"value":"HK.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.8"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["C14195A","G23222A"],"S":["E554K"],"nsp12":["T252N"]},"labels":{"aa":"S: E554K; nsp12: T252N","spike_mutations":"E554K"}}},{"name":"NODE_0000425","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.2"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{"nuc":["G1T","C853T","C21602A"],"S":["Q14K"]},"labels":{"aa":"S: Q14K","spike_mutations":"Q14K"}},"children":[{"name":"HK.3.2.1","node_attrs":{"div":117,"Nextclade_pango":{"value":"HK.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.1"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["A708C","C2106T","C10969T","C20594T","G23593T","G28056A"],"ORF8":["A55T"],"S":["Q677H"],"nsp1":["E148A"],"nsp15":["T325I"],"nsp2":["T434I"]},"labels":{"aa":"ORF8: A55T; S: Q677H; nsp1: E148A; nsp15: T325I; nsp2: T434I","spike_mutations":"Q677H"}}},{"name":"HK.3.2","node_attrs":{"div":111,"Nextclade_pango":{"value":"HK.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-3.817934274673462}},"branch_attrs":{"mutations":{}}},{"name":"HK.3.2.2","node_attrs":{"div":118,"Nextclade_pango":{"value":"HK.3.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.36673000000000006"},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1968892804259947"},"clade_display":{"value":"23H (HK.3)"},"partiallyAliased":{"value":"XBB.1.9.2.5.1.1.3.2.2"},"clade_nextstrain":{"value":"23H"},"clade_membership":{"value":"23H"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C100T","C1348T","C4543T","G7290A","A22115G","T25496C","A27894T"],"ORF3a":["I35T"],"ORF8":["M1L"],"S":["N185D"],"nsp3":["G1524E"]},"labels":{"aa":"ORF3a: I35T; ORF8: M1L; S: N185D; nsp3: G1524E","spike_mutations":"N185D"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000426","node_attrs":{"div":0,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.734287738800049}},"branch_attrs":{"mutations":{}},"children":[{"name":"B.3","node_attrs":{"div":2,"Nextclade_pango":{"value":"B.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.3"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.030364513397217}},"branch_attrs":{"mutations":{"nuc":["G1440A","G2891A"],"nsp2":["G212D"],"nsp3":["A58T"]},"labels":{"aa":"nsp2: G212D; nsp3: A58T"}}},{"name":"B.23","node_attrs":{"div":2,"Nextclade_pango":{"value":"B.23"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.23"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.471245765686035}},"branch_attrs":{"mutations":{"nuc":["A1605-","T1606-","G1607-","C20270T","C29870A"],"nsp15":["A217V"],"nsp2":["D268-"]},"labels":{"aa":"nsp15: A217V; nsp2: D268-"}}},{"name":"B.55","node_attrs":{"div":1,"Nextclade_pango":{"value":"B.55"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":0},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.55"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.3334856033325195}},"branch_attrs":{"mutations":{"nuc":["T514C"]}}},{"name":"NODE_0000427","node_attrs":{"div":1,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.376059532165527}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"B.4","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.4"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.114971160888672}},"branch_attrs":{"mutations":{"nuc":["G1397A","T28688C","G29742T"],"nsp2":["V198I"]},"labels":{"aa":"nsp2: V198I"}}},{"name":"NODE_0000428","node_attrs":{"div":3,"Nextclade_pango":{"value":"B"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.5978965759277344}},"branch_attrs":{"mutations":{"nuc":["C14805T","G26144T"],"ORF3a":["G251V"]},"labels":{"aa":"ORF3a: G251V"}},"children":[{"name":"B.39","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.39"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.39"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["A1515G","C9223T","T17247C"],"nsp2":["H237R"]},"labels":{"aa":"nsp2: H237R"}}},{"name":"B.40","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.40"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.40"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-3.6938891410827637}},"branch_attrs":{"mutations":{"nuc":["A2480G","C2558T"],"nsp2":["I559V","P585S"]},"labels":{"aa":"nsp2: I559V, P585S"}}}]},{"name":"NODE_0000429","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.6"},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{"nuc":["C6312A","C13730T","C23929T","C28311T"],"N":["P13L"],"ORF9b":["P10S"],"nsp12":["A97V"],"nsp3":["T1198K"]},"labels":{"aa":"N: P13L; ORF9b: P10S; nsp12: A97V; nsp3: T1198K"}},"children":[{"name":"B.6","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.6"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.395017623901367}},"branch_attrs":{"mutations":{}}},{"name":"B.6.6","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.6.6"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19A"},"partiallyAliased":{"value":"B.6.6"},"clade_nextstrain":{"value":"19A"},"clade_membership":{"value":"19A"},"placement_prior":{"value":-4.402256011962891}},"branch_attrs":{"mutations":{"nuc":["C6310A","C19524T"],"nsp3":["S1197R"]},"labels":{"aa":"nsp3: S1197R"}}}]}]},{"name":"NODE_0000430","node_attrs":{"div":3,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.371846675872803}},"branch_attrs":{"mutations":{"nuc":["A1T","C8782T","T28144C"],"ORF8":["L84S"]},"labels":{"aa":"ORF8: L84S","clade":"19B"}},"children":[{"name":"A.1","node_attrs":{"div":6,"Nextclade_pango":{"value":"A.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-3.6224653720855713}},"branch_attrs":{"mutations":{"nuc":["C17747T","A17858G","C18060T"],"nsp13":["P504L","Y541C"]},"labels":{"aa":"nsp13: P504L, Y541C"}}},{"name":"A","node_attrs":{"div":3,"Nextclade_pango":{"value":"A"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.371846675872803}},"branch_attrs":{"mutations":{}}},{"name":"A.5","node_attrs":{"div":4,"Nextclade_pango":{"value":"A.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":1},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.451474189758301}},"branch_attrs":{"mutations":{"nuc":["C26088T"]}}},{"name":"A.3","node_attrs":{"div":13,"Nextclade_pango":{"value":"A.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.3"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.0400519371032715}},"branch_attrs":{"mutations":{"nuc":["T490A","C3177T","C6040T","G12478A","T18736C","C24034T","T26729C","G28077C","C28896G","A29700G"],"N":["A208G"],"ORF8":["V62L"],"nsp1":["D75E"],"nsp14":["F233L"],"nsp3":["P153L"],"nsp8":["M129I"]},"labels":{"aa":"N: A208G; ORF8: V62L; nsp1: D75E; nsp14: F233L; nsp3: P153L; nsp8: M129I"}}},{"name":"NODE_0000431","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.2"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["T9477A","C14805T","G25979T","C28657T","C28863T"],"N":["S197L"],"ORF3a":["G196V"],"nsp4":["F308Y"]},"labels":{"aa":"N: S197L; ORF3a: G196V; nsp4: F308Y"}},"children":[{"name":"A.2","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000432","node_attrs":{"div":27,"Nextclade_pango":{"value":"A.2.5"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{"nuc":["C275T","C1567T","C4543T","A5234G","A5488G","C10029T","C11005A","C12815T","C16466T","T16857C","T18417C","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T22917G","A23403G","G24697A","C25613T","C26681T","A28272T","G28975T","C29421T"],"N":["M234I","P383L"],"ORF3a":["S74F"],"S":["L141-","G142-","V143-","L452R","D614G"],"nsp1":["L4F"],"nsp13":["P77L"],"nsp3":["K839E"],"nsp4":["T492I"],"nsp6":["H11Q"]},"labels":{"aa":"N: M234I, P383L; ORF3a: S74F; S: L141-, G142-, V143-, L452R, D614G; nsp1: L4F; nsp13: P77L; nsp3: K839E; nsp4: T492I; nsp6: H11Q","spike_mutations":"L141-, G142-, V143-, L452R, D614G"}},"children":[{"name":"A.2.5","node_attrs":{"div":27,"Nextclade_pango":{"value":"A.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.32398796081543}},"branch_attrs":{"mutations":{}}},{"name":"A.2.5.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"A.2.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.2"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.212984561920166}},"branch_attrs":{"mutations":{"nuc":["T15326C","A22525G","G27706T"],"ORF7a":["A105S"],"nsp12":["M629T"]},"labels":{"aa":"ORF7a: A105S; nsp12: M629T"}}},{"name":"A.2.5.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"A.2.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.277773380279541}},"branch_attrs":{"mutations":{"nuc":["C1722T","C29366T"],"N":["P365S"],"nsp2":["A306V"]},"labels":{"aa":"N: P365S; nsp2: A306V"}}},{"name":"A.2.5.3","node_attrs":{"div":30,"Nextclade_pango":{"value":"A.2.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.2.5.3"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.316434860229492}},"branch_attrs":{"mutations":{"nuc":["G2272A","G22992A","C29870A"],"S":["S477N"]},"labels":{"aa":"S: S477N","spike_mutations":"S477N"}}}]}]},{"name":"internal_446d","node_attrs":{"div":5,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.395915508270264}},"branch_attrs":{"mutations":{"nuc":["G28878A","G29742A"],"N":["S202N"]},"labels":{"aa":"N: S202N"}},"children":[{"name":"A.18","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.18"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.22163200378418}},"branch_attrs":{"mutations":{"nuc":["A3234T","C15126T","A23403G","C27812T"],"S":["D614G"],"nsp3":["Q172L"]},"labels":{"aa":"S: D614G; nsp3: Q172L","spike_mutations":"D614G"}}},{"name":"A.21","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.21"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.21"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C10138T","G11417T","G23402A","G25687T"],"ORF3a":["A99S"],"S":["D614N"],"nsp6":["V149F"]},"labels":{"aa":"ORF3a: A99S; S: D614N; nsp6: V149F","spike_mutations":"D614N"}}},{"name":"NODE_0000434","node_attrs":{"div":6,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22468T"]}},"children":[{"name":"A.28","node_attrs":{"div":20,"Nextclade_pango":{"value":"A.28"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.28"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["A481G","G521T","C2197T","G10850A","C12469T","C16391T","G17014T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","A23064C","C23525T","C25904T","C27294T","A27489G","A28272T","C28377T"],"N":["A35V"],"ORF3a":["S171L"],"ORF9b":["R32C"],"S":["H69-","V70-","N501T","H655Y"],"nsp1":["V86F"],"nsp13":["A52V","D260Y"],"nsp5":["A266T"]},"labels":{"aa":"N: A35V; ORF3a: S171L; ORF9b: R32C; S: H69-, V70-, N501T, H655Y; nsp1: V86F; nsp13: A52V, D260Y; nsp5: A266T","spike_mutations":"H69-, V70-, N501T, H655Y"}}},{"name":"NODE_0000435","node_attrs":{"div":7,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A361G"]}},"children":[{"name":"A.19","node_attrs":{"div":9,"Nextclade_pango":{"value":"A.19"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.19"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A12820G","A23403G"],"S":["D614G"]},"labels":{"aa":"S: D614G","spike_mutations":"D614G"}}},{"name":"A.27","node_attrs":{"div":24,"Nextclade_pango":{"value":"A.27"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.27"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.252493381500244}},"branch_attrs":{"mutations":{"nuc":["C1122T","C2509T","A9204G","A11217G","C16466T","A18366G","A20262G","C21614T","T22917G","A23063T","C23520T","C23525T","G23948T","G25218T","T25541C","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","C27247T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28273T"],"ORF3a":["V50A","N257-","P258-"],"ORF8":["D119-","F120-"],"S":["L18F","L452R","N501Y","A653V","H655Y","D796Y","G1219V"],"nsp13":["P77L"],"nsp2":["P106L"],"nsp4":["D217G"],"nsp6":["N82S"]},"labels":{"aa":"ORF3a: V50A, N257-, P258-; ORF8: D119-, F120-; S: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V; nsp13: P77L; nsp2: P106L; nsp4: D217G; nsp6: N82S","spike_mutations":"L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V"}}}]}]},{"name":"NODE_0000436","node_attrs":{"div":7,"Nextclade_pango":{"value":"A"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.347469329833984}},"branch_attrs":{"mutations":{"nuc":["G11230T","G28167A"],"ORF8":["E92K"],"nsp6":["M86I"]},"labels":{"aa":"ORF8: E92K; nsp6: M86I"}},"children":[{"name":"A.25","node_attrs":{"div":8,"Nextclade_pango":{"value":"A.25"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.25"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C5544T"],"nsp3":["T942I"]},"labels":{"aa":"nsp3: T942I"}}},{"name":"A.29","node_attrs":{"div":24,"Nextclade_pango":{"value":"A.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"S:142-143"},"designation_date":{"value":"2021-05-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.29"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G521T","C2110T","C8605T","C9891T","C12970T","G17964T","A19426G","A21069G","G21255T","T21982-","T21983-","T21984-","G21985-","T21992-","A21993-","A22194-","T22195-","T22196-","T22907C","A23063T","T23255C","C23525T","T26767G","G27604T","A28271-","G28337T","C29739T"],"M":["I82S"],"N":["D22Y"],"ORF7a":["V71L"],"ORF9b":["Q18H"],"S":["F140-","L141-","Y144-","N211-","L212I","Y449H","N501Y","F565L","H655Y"],"nsp1":["V86F"],"nsp13":["M576I"],"nsp14":["I463V"],"nsp4":["A446V"]},"labels":{"aa":"M: I82S; N: D22Y; ORF7a: V71L; ORF9b: Q18H; S: F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y; nsp1: V86F; nsp13: M576I; nsp14: I463V; nsp4: A446V","spike_mutations":"F140-, L141-, Y144-, N211-, L212I, Y449H, N501Y, F565L, H655Y"}}},{"name":"NODE_0000437","node_attrs":{"div":18,"Nextclade_pango":{"value":"A.23"},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C4573T","C10747T","G11266T","C16575T","C17745T","C22000T","C22033A","G22661T","G23401T","T24097C","G28378C"],"ORF9b":["R32P"],"S":["F157L","V367F","Q613H"],"nsp6":["L98F"]},"labels":{"aa":"ORF9b: R32P; S: F157L, V367F, Q613H; nsp6: L98F","spike_mutations":"F157L, V367F, Q613H"}},"children":[{"name":"A.23.1","node_attrs":{"div":20,"Nextclade_pango":{"value":"A.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23.1"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["G11521T","C23604G"],"S":["P681R"],"nsp6":["M183I"]},"labels":{"aa":"S: P681R; nsp6: M183I","spike_mutations":"P681R"}}},{"name":"A.23","node_attrs":{"div":18,"Nextclade_pango":{"value":"A.23"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"19B"},"partiallyAliased":{"value":"A.23"},"clade_nextstrain":{"value":"19B"},"clade_membership":{"value":"19B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"NODE_0000438","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{"nuc":["C241T","C3037T","C14408T","A23403G"],"S":["D614G"],"nsp12":["P323L"]},"labels":{"aa":"S: D614G; nsp12: P323L","clade":"20A","spike_mutations":"D614G"}},"children":[{"name":"B.1","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{}}},{"name":"B.1.128","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.128"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.128"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9753756523132324}},"branch_attrs":{"mutations":{"nuc":["C8293T","T18488C","T24739C","A26530G"],"M":["D3G"],"nsp14":["I150T"]},"labels":{"aa":"M: D3G; nsp14: I150T"}}},{"name":"B.1.143","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.143"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.143"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.877503871917725}},"branch_attrs":{"mutations":{"nuc":["C4084T"]}}},{"name":"B.1.126","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.126"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.126"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.10439395904541}},"branch_attrs":{"mutations":{"nuc":["T3011C","G22205T","T27869C","T28853G"],"N":["S194A"],"S":["D215Y"]},"labels":{"aa":"N: S194A; S: D215Y","spike_mutations":"D215Y"}}},{"name":"B.1.179","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.179"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.179"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.580779075622559}},"branch_attrs":{"mutations":{"nuc":["C7834T"]}}},{"name":"B.1.195","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.195"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.195"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.6570916175842285}},"branch_attrs":{"mutations":{"nuc":["A1T","A6466G"]}}},{"name":"B.1.206","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.206"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.206"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.032977104187012}},"branch_attrs":{"mutations":{"nuc":["G2282A","T9742C","C17639T"],"nsp13":["S468L"],"nsp2":["E493K"]},"labels":{"aa":"nsp13: S468L; nsp2: E493K"}}},{"name":"B.1.22","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.22"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.218311786651611}},"branch_attrs":{"mutations":{"nuc":["C1594T","C11109T","G25563T"],"ORF3a":["Q57H"],"nsp6":["A46V"]},"labels":{"aa":"ORF3a: Q57H; nsp6: A46V"}}},{"name":"B.1.222","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.222"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.222"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.235558032989502}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}}},{"name":"B.1.247","node_attrs":{"div":4,"Nextclade_pango":{"value":"B.1.247"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.247"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.055767059326172}},"branch_attrs":{"mutations":{}}},{"name":"B.1.260","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.260"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.260"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.373620986938477}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}}},{"name":"B.1.379","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.379"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.379"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.878320217132568}},"branch_attrs":{"mutations":{"nuc":["A11782G"]}}},{"name":"B.1.377","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.377"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.377"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.68954610824585}},"branch_attrs":{"mutations":{"nuc":["G28300T","G28883A","A28998G"],"N":["Q9H","G204R","Q242R"],"ORF9b":["S6I"]},"labels":{"aa":"N: Q9H, G204R, Q242R; ORF9b: S6I"}}},{"name":"B.1.380","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.380"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.380"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.045155048370361}},"branch_attrs":{"mutations":{"nuc":["C7420T","C12439T","T26017G"],"ORF3a":["S209A"]},"labels":{"aa":"ORF3a: S209A"}}},{"name":"B.1.391","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.391"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.391"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.035617351531982}},"branch_attrs":{"mutations":{"nuc":["C16289T","G25429T"],"ORF3a":["V13L"],"nsp13":["A18V"]},"labels":{"aa":"ORF3a: V13L; nsp13: A18V"}}},{"name":"B.1.393","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.393"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.393"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.217160701751709}},"branch_attrs":{"mutations":{"nuc":["A5040G","G29477T","C29774T"],"N":["D402Y"],"nsp3":["Q774R"]},"labels":{"aa":"N: D402Y; nsp3: Q774R"}}},{"name":"B.1.395","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.395"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.395"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.251682281494141}},"branch_attrs":{"mutations":{"nuc":["C6990T"],"nsp3":["S1424F"]},"labels":{"aa":"nsp3: S1424F"}}},{"name":"B.1.411","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.411"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.411"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.553277492523193}},"branch_attrs":{"mutations":{"nuc":["C1519T","A14774G","G15438T","T16062C","G17334T","C25037T","C27945T"],"ORF8":["Q18*"],"S":["H1159Y"],"nsp12":["D445G","M666I"]},"labels":{"aa":"ORF8: Q18*; S: H1159Y; nsp12: D445G, M666I","spike_mutations":"H1159Y"}}},{"name":"B.1.524","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.524"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.524"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.310485363006592}},"branch_attrs":{"mutations":{"nuc":["C6312T","C8637T","A10124G","C17518T","C21516T","C21622A","C23664T","A28133T","C28854T"],"N":["S194L"],"S":["A701V"],"nsp13":["L428F"],"nsp3":["T1198I"],"nsp4":["T28I"],"nsp5":["T24A"]},"labels":{"aa":"N: S194L; S: A701V; nsp13: L428F; nsp3: T1198I; nsp4: T28I; nsp5: T24A","spike_mutations":"A701V"}}},{"name":"B.1.525","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.525"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Eta"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21D (Eta)"},"partiallyAliased":{"value":"B.1.525"},"clade_nextstrain":{"value":"21D"},"clade_membership":{"value":"21D"},"placement_prior":{"value":-3.2125132083892822}},"branch_attrs":{"mutations":{"nuc":["C1498T","A1807G","G2659A","C6285T","T8593C","C9565T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14407T","C18171T","A20724G","A21717G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G23012A","G23593C","T24224C","C24748T","T26767C","T27205-","T27206-","T27207-","C28278-","T28279-","G28280-","C28308G","A28699G","C28887T","G29543T"],"M":["I82T"],"N":["S2-","D3Y","A12G","T205I"],"ORF6":["F2-"],"ORF9b":["H9D"],"S":["Q52R","A67V","H69-","V70-","Y144-","E484K","Q677H","F888L"],"nsp12":["L323F"],"nsp3":["T1189I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; N: S2-, D3Y, A12G, T205I; ORF6: F2-; ORF9b: H9D; S: Q52R, A67V, H69-, V70-, Y144-, E484K, Q677H, F888L; nsp12: L323F; nsp3: T1189I; nsp6: S106-, G107-, F108-","clade":"Eta","spike_mutations":"Q52R, A67V, H69-, V70-, Y144-, E484K, Q677H, F888L"}}},{"name":"B.1.537","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.537"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.537"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.682881832122803}},"branch_attrs":{"mutations":{"nuc":["G4354A","C6573T","C25528T"],"ORF3a":["L46F"],"nsp3":["S1285F"]},"labels":{"aa":"ORF3a: L46F; nsp3: S1285F"}}},{"name":"B.1.527","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.527"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.527"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.690547943115234}},"branch_attrs":{"mutations":{"nuc":["A1G","C6354T"],"nsp3":["S1212L"]},"labels":{"aa":"nsp3: S1212L"}}},{"name":"B.1.544","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.544"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.544"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.710533142089844}},"branch_attrs":{"mutations":{"nuc":["G13348T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"B.1.540","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.540"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.540"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.101134300231934}},"branch_attrs":{"mutations":{"nuc":["G28221T"],"ORF8":["E110*"]},"labels":{"aa":"ORF8: E110*"}}},{"name":"B.1.549","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.549"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.549"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.000479221343994}},"branch_attrs":{"mutations":{"nuc":["C1514T","G5542T","C10029T","A11451G","G17122T","G17320T","C18463T","G23611A"],"nsp13":["A296S","A362S"],"nsp14":["P142S"],"nsp2":["H237Y"],"nsp3":["Q941H"],"nsp4":["T492I"],"nsp6":["Q160R"]},"labels":{"aa":"nsp13: A296S, A362S; nsp14: P142S; nsp2: H237Y; nsp3: Q941H; nsp4: T492I; nsp6: Q160R"}}},{"name":"B.1.538","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.538"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.538"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.967286109924316}},"branch_attrs":{"mutations":{"nuc":["C313T","C5700A","C29870A"],"nsp3":["A994D"]},"labels":{"aa":"nsp3: A994D"}}},{"name":"B.1.560","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.560"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.560"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.9053778648376465}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}}},{"name":"B.1.618","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.618"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.618"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G105T","C853T","C1684T","A3830G","C4809T","T5263C","G14245A","A17066G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","G23012A","T25084C","C25844T","C26885T","G26909T","C27493T","G27852T","A27979T","G28325A","G28628T","G28922T","G28975T","G29372C"],"N":["G18S","A119S","A217S","M234I","E367Q"],"ORF3a":["T151I"],"ORF7a":["P34S"],"ORF7b":["E33*"],"ORF8":["Q29L"],"S":["Y145-","H146-","E484K"],"nsp12":["D269N"],"nsp13":["Y277C"],"nsp3":["S371G","S697F"]},"labels":{"aa":"N: G18S, A119S, A217S, M234I, E367Q; ORF3a: T151I; ORF7a: P34S; ORF7b: E33*; ORF8: Q29L; S: Y145-, H146-, E484K; nsp12: D269N; nsp13: Y277C; nsp3: S371G, S697F","spike_mutations":"Y145-, H146-, E484K"}}},{"name":"B.1.639","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.639"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.639"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.999648571014404}},"branch_attrs":{"mutations":{"nuc":["T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22020C","C22995A","G23012A","C24138A","G24368T","A26161-","T27919C","A28271G","A28742G"],"N":["I157V"],"ORF3a":["N257-"],"ORF8":["I9T"],"S":["H69-","V70-","M153T","T478K","E484K","T859N","D936Y"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: I157V; ORF3a: N257-; ORF8: I9T; S: H69-, V70-, M153T, T478K, E484K, T859N, D936Y; nsp6: S106-, G107-, F108-","spike_mutations":"H69-, V70-, M153T, T478K, E484K, T859N, D936Y"}}},{"name":"B.1.8","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.8"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.388725757598877}},"branch_attrs":{"mutations":{"nuc":["A24862G"]}}},{"name":"B.1.78","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.78"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.78"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.461181163787842}},"branch_attrs":{"mutations":{"nuc":["G29422T"]}}},{"name":"B.1.91","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.91"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.91"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.197771072387695}},"branch_attrs":{"mutations":{"nuc":["G24077T"],"S":["D839Y"]},"labels":{"aa":"S: D839Y","spike_mutations":"D839Y"}}},{"name":"NODE_0000439","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.110"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.563884258270264}},"branch_attrs":{"mutations":{"nuc":["C8389T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.110","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.110"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.563884258270264}},"branch_attrs":{"mutations":{}}},{"name":"B.1.110.3","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.110.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.110.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.013157367706299}},"branch_attrs":{"mutations":{"nuc":["C601T","G27915A"],"ORF8":["G8R"]},"labels":{"aa":"ORF8: G8R"}}}]},{"name":"NODE_0000440","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.797828674316406}},"branch_attrs":{"mutations":{"nuc":["G3871T"],"nsp3":["K384N"]},"labels":{"aa":"nsp3: K384N"}},"children":[{"name":"B.1.378","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1.378"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.378"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.797828674316406}},"branch_attrs":{"mutations":{"nuc":["A6-","G7-","G8-","T9-","T13-","A14-","C15-","C16-","T17-","T18-","C19-","C20-","C21-","A22-","G23-","G24-"]}}},{"name":"NODE_0000441","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.391294956207275}},"branch_attrs":{"mutations":{"nuc":["A696C","T3931C","C28977T"],"N":["S235F"],"nsp1":["D144A"]},"labels":{"aa":"N: S235F; nsp1: D144A"}},"children":[{"name":"B.1.139","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.139"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.139"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.391294956207275}},"branch_attrs":{"mutations":{}}},{"name":"B.1.565","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.565"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.565"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8670549392700195}},"branch_attrs":{"mutations":{"nuc":["C6285T","C19524T","C20429T"],"nsp15":["P270L"],"nsp3":["T1189I"]},"labels":{"aa":"nsp15: P270L; nsp3: T1189I"}}}]}]},{"name":"NODE_0000442","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.837924003601074}},"branch_attrs":{"mutations":{"nuc":["T11288-","T11290-","T11293-","T11294-","T11295-","T11296-","C23625T","A26161-"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"B.1.634","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.634"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.634"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G613A","C841T","A7142G","T8634C","A9614G","C9693T","A9754C","C11289-","G11291-","G11292-","G15451A","C16466T","C20823T","T21615G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","A22036C","G23012A","C23854A","C26681T","T27645C","C27735T","A28271T","C28531T","C28606T","A28910T"],"N":["N213Y"],"ORF3a":["N257-"],"ORF9b":["T83I"],"S":["L18R","H69-","V70-","T95I","R158S","E484K","N764K"],"nsp12":["G671S"],"nsp13":["P77L"],"nsp3":["S1475G"],"nsp4":["I27T","T354A","A380V","R400S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: N213Y; ORF3a: N257-; ORF9b: T83I; S: L18R, H69-, V70-, T95I, R158S, E484K, N764K; nsp12: G671S; nsp13: P77L; nsp3: S1475G; nsp4: I27T, T354A, A380V, R400S; nsp6: S106-, G107-, F108-","spike_mutations":"L18R, H69-, V70-, T95I, R158S, E484K, N764K"}}},{"name":"NODE_0000443","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.440206527709961}},"branch_attrs":{"mutations":{"nuc":["C24642T"],"S":["T1027I"]},"labels":{"aa":"S: T1027I","spike_mutations":"T1027I"}},"children":[{"name":"B.1.636","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.636"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.636"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1594T","C5907T","C5986T","A9085G","C11289-","G11291-","G11292-","C21614T","A22005C","G23867A","C25931T","-26161A","C27925T","A28295T","A28742G","G29734C"],"N":["N8Y","I157V"],"ORF3a":["S180F"],"ORF8":["T11I"],"ORF9b":["K4N"],"S":["L18F","N148T","G769R"],"nsp3":["T1063I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: N8Y, I157V; ORF3a: S180F; ORF8: T11I; ORF9b: K4N; S: L18F, N148T, G769R; nsp3: T1063I; nsp6: S106-, G107-, F108-","spike_mutations":"L18F, N148T, G769R"}}},{"name":"NODE_0000444","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A994G","G9756A","C9924T","A10982G","G11283-","T11284-","-11288T","-11290T","-11293T","-11294T","-11295T","-11296T","C23604A","T23765G","C24442T","G26158-","T26159-","T26160-","C26222T"],"ORF3a":["V256-","N257-"],"S":["P681H","S735A"],"nsp4":["R401H","A457V"],"nsp6":["K4E","S104-"]},"labels":{"aa":"ORF3a: V256-, N257-; S: P681H, S735A; nsp4: R401H, A457V; nsp6: K4E, S104-","spike_mutations":"P681H, S735A"}},"children":[{"name":"B.1.627","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.627"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.627"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["C1912T","C7869T","C9611T","T11285-","T20124A","T21752A","T22020C","C28923T","T29576-","T29577-","C29578-","G29579-","C29580-","T29581-","T29582-"],"N":["A217V"],"ORF10":["F7-","A8-","F9-"],"S":["W64R","M153T"],"nsp3":["S1717L"],"nsp4":["L353F"],"nsp6":["L105M"]},"labels":{"aa":"N: A217V; ORF10: F7-, A8-, F9-; S: W64R, M153T; nsp3: S1717L; nsp4: L353F; nsp6: L105M","spike_mutations":"W64R, M153T"}}},{"name":"B.1.631","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.631"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-07-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.631"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C829T","C4534T","C6120T","G7787A","A11282-","T21615G","C21846T","A22036C","C22916A","C25465T","C27769T","A28271-","A28330G","C28830T","G28907T","C28957T"],"N":["S186F","G212C"],"ORF3a":["P25S"],"ORF7b":["S5L"],"ORF9b":["D16G"],"S":["L18R","T95I","R158S","L452M"],"nsp3":["S1134L","A1690T"]},"labels":{"aa":"N: S186F, G212C; ORF3a: P25S; ORF7b: S5L; ORF9b: D16G; S: L18R, T95I, R158S, L452M; nsp3: S1134L, A1690T","spike_mutations":"L18R, T95I, R158S, L452M"}}}]}]}]},{"name":"NODE_0000445","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.317669153213501}},"branch_attrs":{"mutations":{"nuc":["C2416T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.279","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.279"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.279"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.854539155960083}},"branch_attrs":{"mutations":{"nuc":["C1913T","G2528A","C12525T","C16806T","G20014T","A25718G"],"ORF3a":["Y109C"],"nsp15":["D132Y"],"nsp2":["R370C","E575K"],"nsp8":["T145I"]},"labels":{"aa":"ORF3a: Y109C; nsp15: D132Y; nsp2: R370C, E575K; nsp8: T145I"}}},{"name":"NODE_0000446","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.214023113250732}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.389","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.389"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.389"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G8371T","C9430T","A15477T","C18395T","A20622T","G20623T","A20624T","C23730T","A26319G","G29044A"],"S":["T723I"],"nsp14":["A119V"],"nsp15":["K334N","D335F"],"nsp3":["Q1884H"]},"labels":{"aa":"S: T723I; nsp14: A119V; nsp15: K334N, D335F; nsp3: Q1884H","spike_mutations":"T723I"}}},{"name":"B.1.480","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.480"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.480"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.699550151824951}},"branch_attrs":{"mutations":{"nuc":["C875T","A10904G","G25249T"],"S":["M1229I"],"nsp2":["L24F"],"nsp5":["S284G"]},"labels":{"aa":"S: M1229I; nsp2: L24F; nsp5: S284G","spike_mutations":"M1229I"}}}]},{"name":"NODE_0000447","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.958614826202393}},"branch_attrs":{"mutations":{"nuc":["C14322T","C23604A","G23948T","T26038C"],"ORF3a":["S216P"],"S":["P681H","D796Y"]},"labels":{"aa":"ORF3a: S216P; S: P681H, D796Y","spike_mutations":"P681H, D796Y"}},"children":[{"name":"B.1.474","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.474"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.474"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.585630416870117}},"branch_attrs":{"mutations":{"nuc":["C539T","C5884T","C7834T","G8618A","C15579T","G16912T","C25207T","C26600T","C27970A","C28887T"],"N":["T205I"],"ORF8":["T26N"],"nsp1":["L92F"],"nsp13":["V226L"],"nsp4":["A22T"]},"labels":{"aa":"N: T205I; ORF8: T26N; nsp1: L92F; nsp13: V226L; nsp4: A22T"}}},{"name":"B.1.629","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.629"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.629"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C815T","C1191T","C3040T","A4229C","T5095C","C5178T","G11128A","C12459T","G21987A","A22107G","T22917G","C22995A","G25266T","C25433T","T26498C","T26767G","A28482G","C28833T","C28926T"],"M":["I82S"],"N":["Q70R","S187L","A218V"],"ORF3a":["T14I"],"ORF9b":["K67E"],"S":["G142D","K182R","L452R","T478K","C1235F"],"nsp2":["R4C","P129L"],"nsp3":["T504P","T820I"],"nsp6":["M52I"],"nsp8":["T123I"]},"labels":{"aa":"M: I82S; N: Q70R, S187L, A218V; ORF3a: T14I; ORF9b: K67E; S: G142D, K182R, L452R, T478K, C1235F; nsp2: R4C, P129L; nsp3: T504P, T820I; nsp6: M52I; nsp8: T123I","spike_mutations":"G142D, K182R, L452R, T478K, C1235F"}}}]}]},{"name":"NODE_0000448","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.357755661010742}},"branch_attrs":{"mutations":{"nuc":["C15324T"]}},"children":[{"name":"B.1.146","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.146"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.146"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C10833T","G28747T","G28917T","G29543T"],"N":["G215V"],"nsp5":["A260V"]},"labels":{"aa":"N: G215V; nsp5: A260V"}}},{"name":"B.1.147","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.147"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.147"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.98856782913208}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"B.1.149","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.149"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.149"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.820705890655518}},"branch_attrs":{"mutations":{"nuc":["G16846T"],"nsp13":["D204Y"]},"labels":{"aa":"nsp13: D204Y"}}},{"name":"B.1.210","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.210"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.210"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.527243614196777}},"branch_attrs":{"mutations":{"nuc":["A1C","C3634T"]}}},{"name":"B.1.212","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.212"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.212"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.8698015213012695}},"branch_attrs":{"mutations":{"nuc":["C16428T"]}}},{"name":"B.1.221","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.221"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.221"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.022773027420044}},"branch_attrs":{"mutations":{"nuc":["C3602T","C6941T","C21855T","A25505G","G25906C","G25996T","C28651T","C28869T"],"N":["P199L"],"ORF3a":["Q38R","G172R","V202L"],"S":["S98F"],"nsp3":["H295Y"]},"labels":{"aa":"N: P199L; ORF3a: Q38R, G172R, V202L; S: S98F; nsp3: H295Y","spike_mutations":"S98F"}}},{"name":"B.1.219","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.219"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.219"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.373754501342773}},"branch_attrs":{"mutations":{"nuc":["T13A","C16193T","A22404T"],"S":["E281V"],"nsp12":["P918L"]},"labels":{"aa":"S: E281V; nsp12: P918L","spike_mutations":"E281V"}}},{"name":"B.1.620","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.620"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.620"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A22T","C1473T","G6236A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G17110T","T20049C","C21638T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21939C","T21992-","A21993-","T21994-","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","C22295T","C22498T","G22992A","G23012A","A23416T","C23604A","C24642T","G24914C","A28271T","T28297C","C28932T"],"N":["A220V"],"ORF9b":["I5T"],"S":["P26S","H69-","V70-","V126A","Y144-","L241-","L242-","A243-","H245Y","S477N","E484K","P681H","T1027I","D1118H"],"nsp13":["A292S"],"nsp2":["T223I"],"nsp3":["V1173I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: A220V; ORF9b: I5T; S: P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H; nsp13: A292S; nsp2: T223I; nsp3: V1173I; nsp6: S106-, G107-, F108-","spike_mutations":"P26S, H69-, V70-, V126A, Y144-, L241-, L242-, A243-, H245Y, S477N, E484K, P681H, T1027I, D1118H"}}}]},{"name":"NODE_0000449","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9689385890960693}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.530","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.530"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.530"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G61T","A3291G","C11050T","G16935T","A19339G","C23604A","C26549T","T29471C"],"S":["P681H"],"nsp13":["M233I"],"nsp14":["S434G"],"nsp3":["Q191R"]},"labels":{"aa":"S: P681H; nsp13: M233I; nsp14: S434G; nsp3: Q191R","spike_mutations":"P681H"}}},{"name":"NODE_0000450","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.214"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-7.439484119415283}},"branch_attrs":{"mutations":{"nuc":["A4457G","C5907T","C12312T","C15324T"],"nsp3":["I580V","T1063I"],"nsp8":["A74V"]},"labels":{"aa":"nsp3: I580V, T1063I; nsp8: A74V"}},"children":[{"name":"B.1.214.1","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.214.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.222192764282227}},"branch_attrs":{"mutations":{"nuc":["A481G","C5144T","C17304G","C17999T"],"nsp13":["T588I"]},"labels":{"aa":"nsp13: T588I"}}},{"name":"B.1.214","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.214"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.219902992248535}},"branch_attrs":{"mutations":{"nuc":["T28887C"],"N":["I205T"]},"labels":{"aa":"N: I205T"}}},{"name":"NODE_0000451","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.214"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C4891T","A15187G","C23709T","T27576C","G28280C","A28281T","T28282A","C28846T"],"N":["D3L"],"S":["T716I"],"nsp12":["R583G"]},"labels":{"aa":"N: D3L; S: T716I; nsp12: R583G","spike_mutations":"T716I"}},"children":[{"name":"B.1.214.2","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.214.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:29-276"},"designation_date":{"value":"2021-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9553585052490234}},"branch_attrs":{"mutations":{"nuc":["C22802A","T22912G","A25448-","A25449-","A25450-","T25451-","C25452-","A25453-","A25454-","G25455-","G25456-","A25457-","T25458-","G25459-","C25460-","T25461-","A25462-","C25463-","T25464-","C25465-","C25466-","T25467-","T25468-","C25469-","A25470-","G25471-","A25472-","T25473-","T25474-","T25475-"],"ORF3a":["E19-","I20-","K21-","D22-","A23-","T24-","P25-","S26-","D27-","F28-"],"S":["Q414K","N450K"]},"labels":{"aa":"ORF3a: E19-, I20-, K21-, D22-, A23-, T24-, P25-, S26-, D27-, F28-; S: Q414K, N450K","spike_mutations":"Q414K, N450K"}}},{"name":"B.1.214.3","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.214.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.214.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C673T","A11282-","G11283-","T11284-","T11285-","T11286-","G11287-","T11288-","C11289-","T11290-","G11291T","A11430G","C21846T"],"S":["T95I"],"nsp6":["S104-","L105-","S106-","G107C","Y153C"]},"labels":{"aa":"S: T95I; nsp6: S104-, L105-, S106-, G107C, Y153C","spike_mutations":"T95I"}}}]}]},{"name":"NODE_0000452","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.162606716156006}},"branch_attrs":{"mutations":{"nuc":["T26767C"],"M":["I82T"]},"labels":{"aa":"M: I82T"}},"children":[{"name":"NODE_0000453","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.605557441711426}},"branch_attrs":{"mutations":{"nuc":["C23604A","C24138A","A28271-"],"S":["P681H","T859N"]},"labels":{"aa":"S: P681H, T859N","spike_mutations":"P681H, T859N"}},"children":[{"name":"B.1.415.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.415.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.415.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C1150T","T7185C","C8251T","A11023T","A11217G","C13458T","G15732T","T16348C","A16619G","A18410G","T19143C","A20268G","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C22286-","T22287-","T22288-","G22299C","G22599A","G23012A","A23064C","C24507T","G26840T","G28178A","G28302A","C28932T"],"N":["R10Q","A220V"],"ORF9b":["E7K"],"S":["H69-","V70-","L241-","R246T","R346K","E484K","N501T","S982L"],"nsp11":["S6L"],"nsp12":["S6L"],"nsp13":["S38P","E128G"],"nsp14":["Y124C"],"nsp3":["I1489T"],"nsp6":["N82S"]},"labels":{"aa":"N: R10Q, A220V; ORF9b: E7K; S: H69-, V70-, L241-, R246T, R346K, E484K, N501T, S982L; nsp11: S6L; nsp12: S6L; nsp13: S38P, E128G; nsp14: Y124C; nsp3: I1489T; nsp6: N82S","spike_mutations":"H69-, V70-, L241-, R246T, R346K, E484K, N501T, S982L"}}},{"name":"B.1.640.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"B.1.640.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.640.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C601T","C1191T","A1620G","C2416T","C2455T","G6622T","C9711T","G9756A","C10029T","T11418C","C11956T","C16575T","C16869T","C20283T","C21588T","G21848C","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","G22132T","T22191C","A22600C","A22743G","T22907A","T23030C","T23031G","A23063T","G24368C","C25487T","G25563T","A26492T","C27513T","C27807T","C27972T","T28297C","G28337T","T29377C","G29405C","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","G29779T"],"N":["D22Y","E378Q"],"ORF3a":["T32I","Q57H"],"ORF8":["Q27*"],"ORF9b":["I5T","Q18H"],"S":["P9L","E96Q","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","R190S","I210T","R346S","N394S","Y449N","F490R","N501Y","D936H"],"nsp2":["P129L","E272G"],"nsp3":["L1301F"],"nsp4":["S386F","R401H","T492I"],"nsp6":["V149A"]},"labels":{"aa":"N: D22Y, E378Q; ORF3a: T32I, Q57H; ORF8: Q27*; ORF9b: I5T, Q18H; S: P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, R190S, I210T, R346S, N394S, Y449N, F490R, N501Y, D936H; nsp2: P129L, E272G; nsp3: L1301F; nsp4: S386F, R401H, T492I; nsp6: V149A","spike_mutations":"P9L, E96Q, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, R190S, I210T, R346S, N394S, Y449N, F490R, N501Y, D936H"}}}]},{"name":"NODE_0000454","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.619"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2407A","G5008T","C6633T","G8084A","C8311T","C9319T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G11521T","C12473T","C14403T","C15324T","G19962A","C21637T","T22191C","T22882G","G23012A","T24194C","G24368A","C24378T","C24642T","G26211T","C26606T","G27459T","C28311T","G28875T"],"N":["P13L","S201I"],"ORF7a":["E22D"],"ORF9b":["P10S"],"S":["I210T","N440K","E484K","D936N","S939F","T1027I"],"nsp3":["A1305V","E1789K"],"nsp6":["S106-","G107-","F108-","M183I"]},"labels":{"aa":"N: P13L, S201I; ORF7a: E22D; ORF9b: P10S; S: I210T, N440K, E484K, D936N, S939F, T1027I; nsp3: A1305V, E1789K; nsp6: S106-, G107-, F108-, M183I","spike_mutations":"I210T, N440K, E484K, D936N, S939F, T1027I"}},"children":[{"name":"B.1.619","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.619"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"B.1.619.1","node_attrs":{"div":38,"Nextclade_pango":{"value":"B.1.619.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.619.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C19T","T5701C","A12051G","A21213G","T22738C","A28271-","C28441T","T28600C","C28957T"],"ORF9b":["S53L"],"nsp7":["K70R"]},"labels":{"aa":"ORF9b: S53L; nsp7: K70R"}}}]}]}]},{"name":"NODE_0000455","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.1044530868530273}},"branch_attrs":{"mutations":{"nuc":["T445C","C6286T","G21255C","C22227T","C26801G","C28932T","G29645T"],"N":["A220V"],"ORF10":["V30L"],"S":["A222V"]},"labels":{"aa":"N: A220V; ORF10: V30L; S: A222V","clade":"20E","spike_mutations":"A222V"}},"children":[{"name":"B.1.177","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.177"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.1044530868530273}},"branch_attrs":{"mutations":{}}},{"name":"B.1.177.15","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.15"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.15"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.812208652496338}},"branch_attrs":{"mutations":{"nuc":["C5170T","C10078T","G11132T","G11417T","G22051T","G29179T"],"nsp6":["A54S","V149F"]},"labels":{"aa":"nsp6: A54S, V149F"}}},{"name":"B.1.177.18","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.18"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.1767425537109375}},"branch_attrs":{"mutations":{"nuc":["A10323G","G23311C","G25440T","C27752T"],"ORF3a":["K16N"],"ORF7a":["T120I"],"S":["E583D"],"nsp5":["K90R"]},"labels":{"aa":"ORF3a: K16N; ORF7a: T120I; S: E583D; nsp5: K90R","spike_mutations":"E583D"}}},{"name":"B.1.177.16","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.16"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.051562786102295}},"branch_attrs":{"mutations":{"nuc":["C28310A"],"N":["P13T"],"ORF9b":["H9Q"]},"labels":{"aa":"N: P13T; ORF9b: H9Q"}}},{"name":"B.1.177.32","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.32"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.204548358917236}},"branch_attrs":{"mutations":{"nuc":["C5700T","C11152T"],"nsp3":["A994V"]},"labels":{"aa":"nsp3: A994V"}}},{"name":"B.1.177.73","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.73"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.73"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.086843013763428}},"branch_attrs":{"mutations":{"nuc":["G1820A","A2473G","T7543C","C13671T","A24774T","C26060A"],"ORF3a":["T223N"],"S":["Q1071L"],"nsp2":["G339S"]},"labels":{"aa":"ORF3a: T223N; S: Q1071L; nsp2: G339S","spike_mutations":"Q1071L"}}},{"name":"B.1.177.75","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.75"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.75"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.156762599945068}},"branch_attrs":{"mutations":{"nuc":["A1C","T8284C"]}}},{"name":"NODE_0000456","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.143012046813965}},"branch_attrs":{"mutations":{"nuc":["C222T","T20661C","C29386T"]}},"children":[{"name":"B.1.177.44","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.44"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.44"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.074658393859863}},"branch_attrs":{"mutations":{"nuc":["G21468T"],"nsp16":["M270I"]},"labels":{"aa":"nsp16: M270I"}}},{"name":"NODE_0000457","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.473905563354492}},"branch_attrs":{"mutations":{"nuc":["C29366T"],"N":["P365S"]},"labels":{"aa":"N: P365S"}},"children":[{"name":"B.1.177.12","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.12"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.12"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.39573073387146}},"branch_attrs":{"mutations":{"nuc":["T24814C","G25757T"],"ORF3a":["R122I"]},"labels":{"aa":"ORF3a: R122I"}}},{"name":"B.1.177.35","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.35"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.8779044151306152}},"branch_attrs":{"mutations":{"nuc":["T26966C"]}}}]}]},{"name":"NODE_0000458","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.924924850463867}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}},"children":[{"name":"B.1.177.10","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.10"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.106119155883789}},"branch_attrs":{"mutations":{"nuc":["G28321A"],"ORF9b":["R13H"]},"labels":{"aa":"ORF9b: R13H"}}},{"name":"B.1.177.46","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.46"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.46"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.15555477142334}},"branch_attrs":{"mutations":{"nuc":["C9693T","C18508T","G29179T"],"nsp14":["L157F"],"nsp4":["A380V"]},"labels":{"aa":"nsp14: L157F; nsp4: A380V"}}},{"name":"NODE_0000459","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4437451362609863}},"branch_attrs":{"mutations":{"nuc":["C1513T","C22377T"],"S":["P272L"]},"labels":{"aa":"S: P272L","spike_mutations":"P272L"}},"children":[{"name":"B.1.177.82","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.82"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.82"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.837984561920166}},"branch_attrs":{"mutations":{"nuc":["G28378T","G29757T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.177.83","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.83"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.83"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.299724578857422}},"branch_attrs":{"mutations":{"nuc":["C2062T"]}}},{"name":"B.1.177.87","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.87"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.87"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.9360873699188232}},"branch_attrs":{"mutations":{"nuc":["C28706T","C29095T"],"N":["H145Y"]},"labels":{"aa":"N: H145Y"}}}]}]},{"name":"NODE_0000460","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.161717653274536}},"branch_attrs":{"mutations":{"nuc":["C27944T"]}},"children":[{"name":"B.1.177.4","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.4"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.478666067123413}},"branch_attrs":{"mutations":{"nuc":["C66T","A1987G","G10870T","C25614T"]}}},{"name":"B.1.177.52","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.52"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.52"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.295443534851074}},"branch_attrs":{"mutations":{"nuc":["A1T","G5023T","C25047G"],"S":["P1162R"],"nsp3":["M768I"]},"labels":{"aa":"S: P1162R; nsp3: M768I","spike_mutations":"P1162R"}}},{"name":"B.1.177.81","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.81"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.81"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.3990318775177}},"branch_attrs":{"mutations":{"nuc":["C12119T","A21222T","C25889T"],"ORF3a":["S166L"],"nsp8":["P10S"]},"labels":{"aa":"ORF3a: S166L; nsp8: P10S"}}},{"name":"NODE_0000461","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.53"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.278009414672852}},"branch_attrs":{"mutations":{"nuc":["C2973T","G9805T"],"nsp3":["A85V"]},"labels":{"aa":"nsp3: A85V"}},"children":[{"name":"B.1.177.53","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.53"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.278009414672852}},"branch_attrs":{"mutations":{}}},{"name":"W.1","node_attrs":{"div":18,"Nextclade_pango":{"value":"W.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.53.1"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-5.000479221343994}},"branch_attrs":{"mutations":{"nuc":["C17463T","C17676T","T24799C","G25785T"],"ORF3a":["W131C"]},"labels":{"aa":"ORF3a: W131C"}}}]},{"name":"NODE_0000462","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.13129186630249}},"branch_attrs":{"mutations":{"nuc":["G204T"]}},"children":[{"name":"B.1.177.21","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177.21"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.21"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.0787036418914795}},"branch_attrs":{"mutations":{"nuc":["T16242A"]}}},{"name":"B.1.177.77","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.77"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.77"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.0452117919921875}},"branch_attrs":{"mutations":{"nuc":["T3592C","C13517T"],"nsp12":["T26I"]},"labels":{"aa":"nsp12: T26I"}}},{"name":"NODE_0000463","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.644141674041748}},"branch_attrs":{"mutations":{"nuc":["C9745T"]}},"children":[{"name":"B.1.177.54","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.177.54"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.54"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.974447011947632}},"branch_attrs":{"mutations":{"nuc":["C23644T","T25878C","G25879A","A25881T"],"ORF3a":["V163I"]},"labels":{"aa":"ORF3a: V163I"}}},{"name":"NODE_0000464","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.35325288772583}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"nsp3":["A1736V"]},"labels":{"aa":"nsp3: A1736V"}},"children":[{"name":"B.1.177.57","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.57"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.57"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.707308769226074}},"branch_attrs":{"mutations":{"nuc":["C6807T"],"nsp3":["T1363I"]},"labels":{"aa":"nsp3: T1363I"}}},{"name":"B.1.177.56","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.56"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.56"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.35325288772583}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000465","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.177"},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-2.566998243331909}},"branch_attrs":{"mutations":{"nuc":["C21614T"],"S":["L18F"]},"labels":{"aa":"S: L18F","spike_mutations":"L18F"}},"children":[{"name":"B.1.177.5","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.5"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.151096820831299}},"branch_attrs":{"mutations":{"nuc":["T24769C","C25460T"],"ORF3a":["A23V"]},"labels":{"aa":"ORF3a: A23V"}}},{"name":"B.1.177.60","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.177.60"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.60"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.3496036529541016}},"branch_attrs":{"mutations":{"nuc":["A1G","G25621T"],"ORF3a":["V77F"]},"labels":{"aa":"ORF3a: V77F"}}},{"name":"B.1.177.62","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.177.62"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.62"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.268250465393066}},"branch_attrs":{"mutations":{"nuc":["C7195T","C21714T","G24368T","G25855T"],"ORF3a":["D155Y"],"S":["T51I","D936Y"]},"labels":{"aa":"ORF3a: D155Y; S: T51I, D936Y","spike_mutations":"T51I, D936Y"}}},{"name":"B.1.177.7","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.7"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.7"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4441723823547363}},"branch_attrs":{"mutations":{"nuc":["C15480T"]}}},{"name":"B.1.177.8","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.177.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.8"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-4.112913131713867}},"branch_attrs":{"mutations":{"nuc":["G8179T"]}}},{"name":"B.1.177.86","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.177.86"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20E"},"partiallyAliased":{"value":"B.1.177.86"},"clade_nextstrain":{"value":"20E"},"clade_membership":{"value":"20E"},"placement_prior":{"value":-3.4548094272613525}},"branch_attrs":{"mutations":{"nuc":["C6040T","G26801T","G27870T"],"ORF7b":["E39*"]},"labels":{"aa":"ORF7b: E39*"}}}]}]}]}]},{"name":"NODE_0000466","node_attrs":{"div":5,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.2661590576171875}},"branch_attrs":{"mutations":{"nuc":["A20268G"]}},"children":[{"name":"B.1.189","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.189"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.189"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.054994106292725}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.192","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.192"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.192"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.370109558105469}},"branch_attrs":{"mutations":{"nuc":["C11833T"]}}},{"name":"B.1.237","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.237"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.237"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.828962326049805}},"branch_attrs":{"mutations":{"nuc":["G2164C"],"nsp2":["E453D"]},"labels":{"aa":"nsp2: E453D"}}},{"name":"B.1.381","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.381"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.381"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.034300327301025}},"branch_attrs":{"mutations":{"nuc":["C355T","C4093T"]}}},{"name":"B.1.420","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.420"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.420"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.054104328155518}},"branch_attrs":{"mutations":{"nuc":["T23443C"]}}},{"name":"B.1.417","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.417"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.417"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.156829357147217}},"branch_attrs":{"mutations":{"nuc":["T5422C","C7051T","G7743T","C12880T"],"nsp3":["S1675I"]},"labels":{"aa":"nsp3: S1675I"}}},{"name":"B.1.600","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.600"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.600"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.995579719543457}},"branch_attrs":{"mutations":{"nuc":["A5G","A6G","G7A","C5784T","C27982T"],"ORF8":["P30L"],"nsp3":["T1022I"]},"labels":{"aa":"ORF8: P30L; nsp3: T1022I"}}},{"name":"B.1.609","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.609"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":2},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.609"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.865769147872925}},"branch_attrs":{"mutations":{"nuc":["C4582T"]}}},{"name":"NODE_0000467","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.416"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.642777442932129}},"branch_attrs":{"mutations":{"nuc":["A1C","C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}},"children":[{"name":"B.1.416","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.416"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.278482437133789}},"branch_attrs":{"mutations":{"nuc":["C1625T"],"nsp2":["L274F"]},"labels":{"aa":"nsp2: L274F"}}},{"name":"B.1.416.1","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.416.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.416.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.303077220916748}},"branch_attrs":{"mutations":{"nuc":["C25731T"]}}}]},{"name":"NODE_0000468","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{"nuc":["A1G","T7767C","C8047T","C17104T","C22879A","G29734C"],"S":["N439K"],"nsp13":["H290Y"],"nsp3":["I1683T"]},"labels":{"aa":"S: N439K; nsp13: H290Y; nsp3: I1683T","spike_mutations":"N439K"}},"children":[{"name":"B.1.258","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.258"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{}}},{"name":"B.1.258.3","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.258.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.964566469192505}},"branch_attrs":{"mutations":{"nuc":["G1464A","A10978T","G18803T","T20799C"],"nsp14":["S255I"],"nsp2":["G220D"]},"labels":{"aa":"nsp14: S255I; nsp2: G220D"}}},{"name":"NODE_0000469","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.993483066558838}},"branch_attrs":{"mutations":{"nuc":["C27800A"]}},"children":[{"name":"B.1.258.14","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.258.14"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.14"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.224915981292725}},"branch_attrs":{"mutations":{"nuc":["G1A","C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}}},{"name":"NODE_0000470","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.258"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.193143606185913}},"branch_attrs":{"mutations":{"nuc":["G12988T","G15598A","G18028T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T24910C","T26972C"],"S":["H69-","V70-"],"nsp12":["V720I"],"nsp13":["A598S"],"nsp9":["M101I"]},"labels":{"aa":"S: H69-, V70-; nsp12: V720I; nsp13: A598S; nsp9: M101I","spike_mutations":"H69-, V70-"}},"children":[{"name":"B.1.258.11","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.258.11"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.11"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.367208480834961}},"branch_attrs":{"mutations":{"nuc":["C12455T","C20451T"],"nsp8":["L122F"]},"labels":{"aa":"nsp8: L122F"}}},{"name":"B.1.258.17","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.258.17"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.258.17"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.1944985389709473}},"branch_attrs":{"mutations":{"nuc":["C829T","C14697T","C16394T","C18176T","G19398T","C22127T","G23876A","G25947T"],"ORF3a":["Q185H"],"S":["L189F","V772I"],"nsp13":["P53L"],"nsp14":["P46L","E453D"]},"labels":{"aa":"ORF3a: Q185H; S: L189F, V772I; nsp13: P53L; nsp14: P46L, E453D","spike_mutations":"L189F, V772I"}}}]}]}]},{"name":"NODE_0000471","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.039437770843506}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.232","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.232"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.232"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8121721744537354}},"branch_attrs":{"mutations":{"nuc":["G27987T"],"ORF8":["V32L"]},"labels":{"aa":"ORF8: V32L"}}},{"name":"B.1.234","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.234"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.234"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.2358059883117676}},"branch_attrs":{"mutations":{"nuc":["G2258A","A6441G","C8140T","A9204G"],"nsp2":["V485I"],"nsp3":["K1241R"],"nsp4":["D217G"]},"labels":{"aa":"nsp2: V485I; nsp3: K1241R; nsp4: D217G"}}},{"name":"B.1.239","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.239"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.239"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.158753395080566}},"branch_attrs":{"mutations":{"nuc":["G16741A"],"nsp13":["V169I"]},"labels":{"aa":"nsp13: V169I"}}},{"name":"B.1.236","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.236"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.236"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.485028266906738}},"branch_attrs":{"mutations":{"nuc":["G11842A","A12759G","G18292T"],"nsp14":["A85S"],"nsp9":["D25G"]},"labels":{"aa":"nsp14: A85S; nsp9: D25G"}}},{"name":"B.1.243","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.243"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.243"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.000774383544922}},"branch_attrs":{"mutations":{"nuc":["T24076C"]}}},{"name":"B.1.241","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.241"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.241"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.9246673583984375}},"branch_attrs":{"mutations":{"nuc":["C11575T"]}}},{"name":"B.1.397","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.397"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.397"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.800171375274658}},"branch_attrs":{"mutations":{"nuc":["G1135T"],"nsp2":["K110N"]},"labels":{"aa":"nsp2: K110N"}}},{"name":"B.1.398","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.398"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.398"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.523492813110352}},"branch_attrs":{"mutations":{"nuc":["G4136A","C11224T","C12295A","C21846T"],"S":["T95I"],"nsp3":["V473I"]},"labels":{"aa":"S: T95I; nsp3: V473I","spike_mutations":"T95I"}}},{"name":"B.1.396","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.396"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.396"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1198410987854}},"branch_attrs":{"mutations":{"nuc":["C1191T","C9521A","C24904T","G29422T","A29567G"],"ORF10":["I4V"],"nsp2":["P129L"],"nsp4":["L323I"]},"labels":{"aa":"ORF10: I4V; nsp2: P129L; nsp4: L323I"}}},{"name":"B.1.399","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.399"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.399"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.258176326751709}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}}},{"name":"B.1.400","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.400"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.400"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.643618583679199}},"branch_attrs":{"mutations":{"nuc":["G19969A"],"nsp15":["A117T"]},"labels":{"aa":"nsp15: A117T"}}},{"name":"B.1.402","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.402"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.402"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.080169677734375}},"branch_attrs":{"mutations":{"nuc":["C4633T","T14643C","C22482T"],"S":["T307I"]},"labels":{"aa":"S: T307I","spike_mutations":"T307I"}}},{"name":"B.1.409","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.409"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.409"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.1198410987854}},"branch_attrs":{"mutations":{"nuc":["G3527A","G5015A","A5877G","G8017T","C11008T","C20283T","C25714T","G25855T","C27434T","C27998T"],"ORF3a":["L108F","D155Y"],"ORF7a":["T14I"],"nsp3":["D270N","V766M","N1053S"]},"labels":{"aa":"ORF3a: L108F, D155Y; ORF7a: T14I; nsp3: D270N, V766M, N1053S"}}},{"name":"B.1.551","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.551"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.551"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.054353713989258}},"branch_attrs":{"mutations":{"nuc":["C3738T","C23604G"],"S":["P681R"],"nsp3":["P340L"]},"labels":{"aa":"S: P681R; nsp3: P340L","spike_mutations":"P681R"}}},{"name":"B.1.558","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.558"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.558"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.004430770874023}},"branch_attrs":{"mutations":{"nuc":["C1288T"]}}},{"name":"NODE_0000472","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.240"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.6813478469848633}},"branch_attrs":{"mutations":{"nuc":["C18486T","T22162C"]}},"children":[{"name":"B.1.240","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.240"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.6813478469848633}},"branch_attrs":{"mutations":{}}},{"name":"B.1.240.1","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.240.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.240.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-8.332109451293945}},"branch_attrs":{"mutations":{"nuc":["G10610T","G10870T","G11335T","C14262T","G29494A"],"nsp5":["V186F"]},"labels":{"aa":"nsp5: V186F"}}}]},{"name":"NODE_0000473","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.489289283752441}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"B.1.404","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.404"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.404"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["G5572T","G7042T","A12644G","T16743C","G19086T","G22992A"],"S":["S477N"],"nsp14":["K349N"],"nsp3":["M951I","M1441I"],"nsp8":["I185V"]},"labels":{"aa":"S: S477N; nsp14: K349N; nsp3: M951I, M1441I; nsp8: I185V","spike_mutations":"S477N"}}},{"name":"B.1.561","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.561"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.561"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.697448492050171}},"branch_attrs":{"mutations":{"nuc":["G2516T","A5999G","C18693T","G21974T","T25577C","G28975T"],"N":["M234I"],"ORF3a":["I62T"],"S":["D138Y"],"nsp2":["V571L"],"nsp3":["I1094V"]},"labels":{"aa":"N: M234I; ORF3a: I62T; S: D138Y; nsp2: V571L; nsp3: I1094V","spike_mutations":"D138Y"}}}]}]}]},{"name":"NODE_0000474","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7314677238464355}},"branch_attrs":{"mutations":{"nuc":["C18877T","G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}},"children":[{"name":"B.1.111","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.111"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.111"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.20757532119751}},"branch_attrs":{"mutations":{"nuc":["C10507T"]}}},{"name":"B.1.170","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.170"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.170"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7314677238464355}},"branch_attrs":{"mutations":{}}},{"name":"B.1.436","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.436"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.436"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.123282432556152}},"branch_attrs":{"mutations":{"nuc":["C28890T","T29710A"],"N":["S206F"]},"labels":{"aa":"N: S206F"}}},{"name":"B.1.438","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.438"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.438"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.653946399688721}},"branch_attrs":{"mutations":{"nuc":["A1154G","G29474T"],"N":["D401Y"],"nsp2":["M117V"]},"labels":{"aa":"N: D401Y; nsp2: M117V"}}},{"name":"B.1.441","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.441"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.441"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.796097755432129}},"branch_attrs":{"mutations":{"nuc":["T8296C","G28690T"],"N":["L139F"]},"labels":{"aa":"N: L139F"}}},{"name":"NODE_0000475","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.9"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.251059532165527}},"branch_attrs":{"mutations":{"nuc":["C7765T","C17690T"],"nsp13":["S485L"]},"labels":{"aa":"nsp13: S485L"}},"children":[{"name":"B.1.9","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.655979633331299}},"branch_attrs":{"mutations":{"nuc":["C2113T"]}}},{"name":"B.1.9.5","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.9.5"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.251059532165527}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000476","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.02042293548584}},"branch_attrs":{"mutations":{"nuc":["C26735T"]}},"children":[{"name":"B.1.459","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.459"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.459"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.765696048736572}},"branch_attrs":{"mutations":{"nuc":["C5184T"],"nsp3":["P822L"]},"labels":{"aa":"nsp3: P822L"}}},{"name":"B.1.462","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.462"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.462"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.719885349273682}},"branch_attrs":{"mutations":{"nuc":["C3811T"]}}},{"name":"B.1.465","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.465"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.465"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.7676591873168945}},"branch_attrs":{"mutations":{"nuc":["G24197T"],"S":["A879S"]},"labels":{"aa":"S: A879S","spike_mutations":"A879S"}}},{"name":"B.1.469","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.469"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.469"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.699280738830566}},"branch_attrs":{"mutations":{"nuc":["A12075G","A21137G","C28866T"],"N":["T198I"],"nsp16":["K160R"],"nsp7":["N78S"]},"labels":{"aa":"N: T198I; nsp16: K160R; nsp7: N78S"}}},{"name":"B.1.471","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.471"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.471"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.839853286743164}},"branch_attrs":{"mutations":{"nuc":["C16915T","T24202C"]}}},{"name":"B.1.470","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.470"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.470"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.865800857543945}},"branch_attrs":{"mutations":{"nuc":["C14120T"],"nsp12":["P227L"]},"labels":{"aa":"nsp12: P227L"}}},{"name":"NODE_0000477","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.160"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-2.896782875061035}},"branch_attrs":{"mutations":{"nuc":["C4543T","G5629T","G9526T","C11497T","G13993T","G15766T","A16889G","G17019T","G22992A","C25710T","T26876C","G28975C","G29399A"],"N":["M234I","A376T"],"S":["S477N"],"nsp12":["A185S","V776L"],"nsp13":["K218R","E261D"],"nsp4":["M324I"]},"labels":{"aa":"N: M234I, A376T; S: S477N; nsp12: A185S, V776L; nsp13: K218R, E261D; nsp4: M324I","spike_mutations":"S477N"}},"children":[{"name":"B.1.160","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.160"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-2.896782875061035}},"branch_attrs":{"mutations":{}}},{"name":"B.1.160.16","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.160.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.160.16"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.024463176727295}},"branch_attrs":{"mutations":{"nuc":["C27434T","C27964T","G29557T"],"ORF7a":["T14I"],"ORF8":["S24L"]},"labels":{"aa":"ORF7a: T14I; ORF8: S24L"}}}]},{"name":"NODE_0000478","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.627126216888428}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36.19","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.19"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.19"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.075583457946777}},"branch_attrs":{"mutations":{"nuc":["A1C","G28086T","C29614T"],"ORF8":["A65S"]},"labels":{"aa":"ORF8: A65S"}}},{"name":"B.1.456","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.456"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.456"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.627126216888428}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000479","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.466"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.84882926940918}},"branch_attrs":{"mutations":{"nuc":["C28887T"],"N":["T205I"]},"labels":{"aa":"N: T205I"}},"children":[{"name":"B.1.466","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.466"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.84882926940918}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000480","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.466"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.935308456420898}},"branch_attrs":{"mutations":{"nuc":["C22879A"],"S":["N439K"]},"labels":{"aa":"S: N439K","spike_mutations":"N439K"}},"children":[{"name":"B.1.466.1","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.466.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["A3423G","C6318A","C15026T","A19960G","G25526T","C25553T","C26111T","A29019G","A29767-","A29768-","C29769-","A29770-","A29771-","T29772-","G29773-","C29774-","T29775-","A29776-"],"N":["K249R"],"ORF3a":["W45L","A54V","P240L"],"nsp12":["A529V"],"nsp15":["T114A"],"nsp3":["K235R","P1200Q"]},"labels":{"aa":"N: K249R; ORF3a: W45L, A54V, P240L; nsp12: A529V; nsp15: T114A; nsp3: K235R, P1200Q"}}},{"name":"NODE_0000481","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.466.2"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.372191429138184}},"branch_attrs":{"mutations":{"nuc":["C3768T","C5184T"],"nsp3":["T350I","P822L"]},"labels":{"aa":"nsp3: T350I, P822L"}},"children":[{"name":"B.1.466.2","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.466.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.372191429138184}},"branch_attrs":{"mutations":{"nuc":["A29897T","A29898G","A29899G","A29902G"]}}},{"name":"NODE_0000482","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.466.2"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.7382194995880127}},"branch_attrs":{"mutations":{"nuc":["C683T","C3096T","C11195T","C12880T","C17012T","T22219C","C23604G","C29718T","C29743T"],"S":["P681R"],"nsp13":["S259L"],"nsp3":["S126L"],"nsp6":["L75F"]},"labels":{"aa":"S: P681R; nsp13: S259L; nsp3: S126L; nsp6: L75F","spike_mutations":"P681R"}},"children":[{"name":"AU.2","node_attrs":{"div":24,"Nextclade_pango":{"value":"AU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2.2"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.538213729858398}},"branch_attrs":{"mutations":{"nuc":["A11117G","C12439T","G20002T","G25314T"],"S":["G1251V"],"nsp15":["D128Y"],"nsp6":["I49V"]},"labels":{"aa":"S: G1251V; nsp15: D128Y; nsp6: I49V","spike_mutations":"G1251V"}}},{"name":"AU.3","node_attrs":{"div":23,"Nextclade_pango":{"value":"AU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.466.2.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.585630416870117}},"branch_attrs":{"mutations":{"nuc":["C8109T","C19586T","G29315C"],"N":["D348H"],"nsp14":["T516I"],"nsp3":["T1797I"]},"labels":{"aa":"N: D348H; nsp14: T516I; nsp3: T1797I"}}}]}]}]}]},{"name":"NODE_0000483","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.616693496704102}},"branch_attrs":{"mutations":{"nuc":["G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}},"children":[{"name":"B.1.523","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.523"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.523"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.616693496704102}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000484","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.105329990386963}},"branch_attrs":{"mutations":{"nuc":["T26735C","A28272G"]}},"children":[{"name":"B.1.438.1","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.438.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.438.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.225435256958008}},"branch_attrs":{"mutations":{"nuc":["A1154G","C8152T","A12121G","G23587T","G25677T","G29474T"],"N":["D401Y"],"ORF3a":["L95F"],"S":["Q675H"],"nsp2":["M117V"]},"labels":{"aa":"N: D401Y; ORF3a: L95F; S: Q675H; nsp2: M117V","spike_mutations":"Q675H"}}},{"name":"NODE_0000485","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-6.198151111602783}},"branch_attrs":{"mutations":{"nuc":["C21846T","A21993-","G23012A","G24410A"],"S":["T95I","Y144-","E484K","D950N"]},"labels":{"aa":"S: T95I, Y144-, E484K, D950N","spike_mutations":"T95I, Y144-, E484K, D950N"}},"children":[{"name":"B.1.625","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.625"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:4-122"},"designation_date":{"value":"2021-06-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.625"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["G521T","C2306T","A4220G","C5730T","C6401T","A10323G","C10775T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T12730G","A13712G","C16694T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","T21994-","C22033A","T22882G","G25244T","T26767C","A27721G","A27897-","A27898-","A27899-","T27900-","T27901-"],"M":["I82T"],"ORF7a":["I110V"],"ORF8":["K2-","F3-"],"S":["H69-","V70-","F157L","N440K","V1228L"],"nsp1":["V86F"],"nsp12":["K91R"],"nsp13":["T153I"],"nsp2":["L501F"],"nsp3":["K501E","T1004I","P1228S"],"nsp5":["K90R","P241S"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; ORF7a: I110V; ORF8: K2-, F3-; S: H69-, V70-, F157L, N440K, V1228L; nsp1: V86F; nsp12: K91R; nsp13: T153I; nsp2: L501F; nsp3: K501E, T1004I, P1228S; nsp5: K90R, P241S; nsp6: S106-, G107-, F108-","spike_mutations":"H69-, V70-, F157L, N440K, V1228L"}}},{"name":"NODE_0000486","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.621"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-3.4022560119628906}},"branch_attrs":{"mutations":{"nuc":["A3428G","C4878T","C6037T","C10029T","A11451G","A13057T","C17491T","T19035C","C20148T","-21993C","T21995A","G22599A","A23063T","C23604A","G26158-","T26159-","T26160-","A26161-","A26492T","C27925A","C28005T","C28093T","G28272T","C28887T","T28975G"],"N":["T205I","I234M"],"ORF3a":["V256-","N257-"],"ORF8":["T11K","P38S","S67F"],"S":["-144S","Y145N","R346K","N501Y","P681H"],"nsp13":["P419S"],"nsp3":["T237A","T720I"],"nsp4":["T492I"],"nsp6":["Q160R"]},"labels":{"aa":"N: T205I, I234M; ORF3a: V256-, N257-; ORF8: T11K, P38S, S67F; S: -144S, Y145N, R346K, N501Y, P681H; nsp13: P419S; nsp3: T237A, T720I; nsp4: T492I; nsp6: Q160R","clade":"Mu","spike_mutations":"-144S, Y145N, R346K, N501Y, P681H"}},"children":[{"name":"B.1.621","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.621"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-3.4022560119628906}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000487","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.621"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.116075038909912}},"branch_attrs":{"mutations":{"nuc":["C5192T","C17707T"],"nsp13":["P491S"]},"labels":{"aa":"nsp13: P491S"}},"children":[{"name":"B.1.621.2","node_attrs":{"div":44,"Nextclade_pango":{"value":"B.1.621.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2022-01-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.2"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["T177C","C2700T","T22907A","G23311T","G26959A","A27675C","G29736A","G29779T"],"M":["R146H"],"ORF7a":["Q94H"],"S":["Y449N","E583D"],"nsp2":["T632I"]},"labels":{"aa":"M: R146H; ORF7a: Q94H; S: Y449N, E583D; nsp2: T632I","spike_mutations":"Y449N, E583D"}}},{"name":"NODE_0000488","node_attrs":{"div":43,"Nextclade_pango":{"value":"B.1.621.1"},"clade_who":{"value":"Mu"},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{"nuc":["A6704G","C9120T","C20402T","T22384A","G26167T","C28657T","T29748C"],"nsp15":["S261L"],"nsp3":["N1329D"],"nsp4":["T189I"]},"labels":{"aa":"nsp15: S261L; nsp3: N1329D; nsp4: T189I"}},"children":[{"name":"B.1.621.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"B.1.621.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.215351581573486}},"branch_attrs":{"mutations":{}}},{"name":"BB.2","node_attrs":{"div":47,"Nextclade_pango":{"value":"BB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Mu"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF3a:258-276"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21H (Mu)"},"partiallyAliased":{"value":"B.1.621.1.2"},"clade_nextstrain":{"value":"21H"},"clade_membership":{"value":"21H"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A6708G","C15963T","C24378T","C29409T"],"N":["T379I"],"S":["S939F"],"nsp3":["K1330R"]},"labels":{"aa":"N: T379I; S: S939F; nsp3: K1330R","spike_mutations":"S939F"}}}]}]}]}]}]}]},{"name":"NODE_0000489","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.841441631317139}},"branch_attrs":{"mutations":{"nuc":["C22444T"]}},"children":[{"name":"B.1.468","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.468"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.468"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.841441631317139}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000490","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{"nuc":["C28854T"],"N":["S194L"]},"labels":{"aa":"N: S194L"}},"children":[{"name":"B.1.36","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.1","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.1"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.350652694702148}},"branch_attrs":{"mutations":{"nuc":["C11224T","C11941T","C12043T"]}}},{"name":"B.1.36.10","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.36.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.10"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.961954355239868}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.16","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.16"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.127261638641357}},"branch_attrs":{"mutations":{"nuc":["A1T","G25494T"]}}},{"name":"B.1.36.22","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.22"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.22"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.128231525421143}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}}},{"name":"B.1.36.24","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.24"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.24"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.737695217132568}},"branch_attrs":{"mutations":{"nuc":["G22201T"]}}},{"name":"B.1.36.35","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.35"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.653663158416748}},"branch_attrs":{"mutations":{"nuc":["G25440T"],"ORF3a":["K16N"]},"labels":{"aa":"ORF3a: K16N"}}},{"name":"B.1.36.29","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.36.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.29"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8213653564453125}},"branch_attrs":{"mutations":{"nuc":["C3267T","C21034T","G26173T","G28183T","T28277C"],"N":["S2P"],"ORF3a":["E261*"],"ORF8":["S97I"],"nsp16":["L126F"],"nsp3":["T183I"]},"labels":{"aa":"N: S2P; ORF3a: E261*; ORF8: S97I; nsp16: L126F; nsp3: T183I"}}},{"name":"B.1.36.31","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.36.31"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.31"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1722T","A8512G","T9877C","G11222T","C12616T","C15738T","A21868T","C22227T","C25463T","G27561T","C28253T","C29095T"],"ORF3a":["T24I"],"S":["R102S","A222V"],"nsp2":["A306V"],"nsp6":["V84F"]},"labels":{"aa":"ORF3a: T24I; S: R102S, A222V; nsp2: A306V; nsp6: V84F","spike_mutations":"R102S, A222V"}}},{"name":"B.1.36.7","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36.7"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.7"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.546401023864746}},"branch_attrs":{"mutations":{"nuc":["A11211G","A22190-","T22191-","T22192-"],"S":["I210-"],"nsp6":["Y80C"]},"labels":{"aa":"S: I210-; nsp6: Y80C","spike_mutations":"I210-"}}},{"name":"B.1.36.8","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.8"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.07541036605835}},"branch_attrs":{"mutations":{"nuc":["A1T","C2836T"]}}},{"name":"B.1.36.9","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.36.9"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":1},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.9"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["G2035T","C2523T","G3994A","C5730T","C9924T","G11083T","C11109T","A22190-","T22191-","T22192-","C24138A"],"S":["I210-","T859N"],"nsp2":["L410F","T573I"],"nsp3":["T1004I"],"nsp4":["A457V"],"nsp6":["L37F","A46V"]},"labels":{"aa":"S: I210-, T859N; nsp2: L410F, T573I; nsp3: T1004I; nsp4: A457V; nsp6: L37F, A46V","spike_mutations":"I210-, T859N"}}},{"name":"NODE_0000491","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.428178548812866}},"branch_attrs":{"mutations":{"nuc":["T1947C"],"nsp2":["V381A"]},"labels":{"aa":"nsp2: V381A"}},"children":[{"name":"B.1.36.36","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.36.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8934714794158936}},"branch_attrs":{"mutations":{"nuc":["C2668T","G4136T","C12141T","C19512T","C28292A","G29179T"],"N":["Q7K"],"nsp3":["V473F"],"nsp8":["T17I"]},"labels":{"aa":"N: Q7K; nsp3: V473F; nsp8: T17I"}}},{"name":"B.1.36.38","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.38"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.272319793701172}},"branch_attrs":{"mutations":{"nuc":["G22918T"]}}},{"name":"NODE_0000492","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-5.259950637817383}},"branch_attrs":{"mutations":{"nuc":["C29555T"]}},"children":[{"name":"B.1.36.18","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.36.18"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.18"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.8423047065734863}},"branch_attrs":{"mutations":{"nuc":["G8027T","G15438T","C18981T","G21785C","C28093T"],"ORF8":["S67F"],"S":["G75R"],"nsp12":["M666I"],"nsp3":["V1770F"]},"labels":{"aa":"ORF8: S67F; S: G75R; nsp12: M666I; nsp3: V1770F","spike_mutations":"G75R"}}},{"name":"NODE_0000493","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}},"children":[{"name":"B.1.36.17","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.36.17"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.17"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.288834571838379}},"branch_attrs":{"mutations":{}}},{"name":"B.1.36.39","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.36.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.36.39"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2319C","C6573T","C9936A","C15981T","C25904T"],"ORF3a":["S171L"],"nsp2":["F505S"],"nsp3":["S1285F"],"nsp4":["T461N"]},"labels":{"aa":"ORF3a: S171L; nsp2: F505S; nsp3: S1285F; nsp4: T461N"}}}]}]}]}]}]}]}]},{"name":"NODE_0000494","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-2.8577709197998047}},"branch_attrs":{"mutations":{"nuc":["C1059T","G25563T"],"ORF3a":["Q57H"],"nsp2":["T85I"]},"labels":{"aa":"ORF3a: Q57H; nsp2: T85I","clade":"20C"}},"children":[{"name":"B.1.298","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.298"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.298"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.423281669616699}},"branch_attrs":{"mutations":{"nuc":["G5012T","C19488T","T28843G"],"N":["S190R"],"nsp3":["V765F"]},"labels":{"aa":"N: S190R; nsp3: V765F"}}},{"name":"B.1.320","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.320"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.320"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.057475566864014}},"branch_attrs":{"mutations":{"nuc":["A1G","C379A"]}}},{"name":"B.1.311","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.311"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.311"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.6200597286224365}},"branch_attrs":{"mutations":{"nuc":["A5011C","C12525T","C27920T","C28893T"],"N":["P207L"],"nsp3":["Q764H"],"nsp8":["T145I"]},"labels":{"aa":"N: P207L; nsp3: Q764H; nsp8: T145I"}}},{"name":"B.1.324","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.324"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.324"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.316860198974609}},"branch_attrs":{"mutations":{"nuc":["C7528T"]}}},{"name":"B.1.319","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.319"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.319"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.238476753234863}},"branch_attrs":{"mutations":{"nuc":["C10851T"],"nsp5":["A266V"]},"labels":{"aa":"nsp5: A266V"}}},{"name":"B.1.340","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.340"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.340"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.6447930335998535}},"branch_attrs":{"mutations":{"nuc":["A4197G","A28715T"],"N":["T148S"],"nsp3":["E493G"]},"labels":{"aa":"N: T148S; nsp3: E493G"}}},{"name":"B.1.346","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.346"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.346"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A12820G","C16762T","A17637G","C20762T","C28887T"],"N":["T205I"],"nsp13":["L176F"],"nsp16":["T35I"]},"labels":{"aa":"N: T205I; nsp13: L176F; nsp16: T35I"}}},{"name":"B.1.350","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.350"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.350"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.54417610168457}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"B.1.349","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.349"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.349"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1025309562683105}},"branch_attrs":{"mutations":{"nuc":["C18555T","C28892T"],"N":["P207S"]},"labels":{"aa":"N: P207S"}}},{"name":"B.1.356","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.356"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.356"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.412571907043457}},"branch_attrs":{"mutations":{"nuc":["T13006C","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}}},{"name":"B.1.362","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.362"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.362"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.247318267822266}},"branch_attrs":{"mutations":{"nuc":["C683T","C6402T","T10249C","G11083T","G17427T","C28854T"],"N":["S194L"],"nsp3":["P1228L"],"nsp6":["L37F"]},"labels":{"aa":"N: S194L; nsp3: P1228L; nsp6: L37F"}}},{"name":"B.1.371","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.371"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.371"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.091424465179443}},"branch_attrs":{"mutations":{"nuc":["G29553A"]}}},{"name":"B.1.433","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.433"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.433"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.620072841644287}},"branch_attrs":{"mutations":{"nuc":["C6843T","T11764C","T17040C","C28887T","G29402T"],"N":["T205I","D377Y"],"nsp3":["S1375F"]},"labels":{"aa":"N: T205I, D377Y; nsp3: S1375F"}}},{"name":"B.1.428","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.428"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.428"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.0384840965271}},"branch_attrs":{"mutations":{"nuc":["C1302T"],"nsp2":["T166I"]},"labels":{"aa":"nsp2: T166I"}}},{"name":"B.1.453","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.453"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.453"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.12796688079834}},"branch_attrs":{"mutations":{"nuc":["C2668T"]}}},{"name":"B.1.566","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.566"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.566"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.346085548400879}},"branch_attrs":{"mutations":{"nuc":["C13860T"]}}},{"name":"B.1.570","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.570"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.570"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.377383708953857}},"branch_attrs":{"mutations":{"nuc":["T7767C","G11087A","C13452T","C21161T","C23604T","G25455T","T29867A","G29868A","C29870A"],"ORF3a":["K21N"],"S":["P681L"],"nsp11":["A4V"],"nsp12":["A4V"],"nsp16":["A168V"],"nsp3":["I1683T"],"nsp6":["E39K"]},"labels":{"aa":"ORF3a: K21N; S: P681L; nsp11: A4V; nsp12: A4V; nsp16: A168V; nsp3: I1683T; nsp6: E39K","spike_mutations":"P681L"}}},{"name":"B.1.576","node_attrs":{"div":6,"Nextclade_pango":{"value":"B.1.576"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.576"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-2.8577709197998047}},"branch_attrs":{"mutations":{}}},{"name":"B.1.605","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.605"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.605"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C10747T","C13694T","T14103C","C24909A"],"S":["T1116N"],"nsp12":["T85I"]},"labels":{"aa":"S: T1116N; nsp12: T85I","spike_mutations":"T1116N"}}},{"name":"B.1.606","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.606"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.606"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.8544087409973145}},"branch_attrs":{"mutations":{"nuc":["C10015T","G14829T","C23191T","G26769T"],"M":["A83S"],"nsp12":["M463I"]},"labels":{"aa":"M: A83S; nsp12: M463I"}}},{"name":"NODE_0000495","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{"nuc":["C16260T","C28821A"],"N":["S183Y"]},"labels":{"aa":"N: S183Y"}},"children":[{"name":"B.1.369","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.369"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.369"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{"nuc":["A1C"]}}},{"name":"B.1.564","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.564"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.564"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7134287357330322}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000496","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.185941696166992}},"branch_attrs":{"mutations":{"nuc":["C10582T","C27804T","C28830A"],"N":["S186Y"]},"labels":{"aa":"N: S186Y"}},"children":[{"name":"B.1.367","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.367"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.367"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C3099T","G4960T","C4965T","C6070T","C7303T","C7564T","C9246T","C10279T","C10301A","C10525T","G10688T","G11851T","C14230A","G21800T","G27632T","G29402T","G29779T"],"N":["D377Y"],"ORF7a":["R80I"],"S":["D80Y"],"nsp12":["P264T"],"nsp3":["T127I","T749I"],"nsp4":["A231V"],"nsp5":["Q83K","V212F"],"nsp7":["M3I"]},"labels":{"aa":"N: D377Y; ORF7a: R80I; S: D80Y; nsp12: P264T; nsp3: T127I, T749I; nsp4: A231V; nsp5: Q83K, V212F; nsp7: M3I","spike_mutations":"D80Y"}}},{"name":"B.1.597","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.597"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.597"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.185941696166992}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000497","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.831107139587402}},"branch_attrs":{"mutations":{"nuc":["G17259T","C28887T"],"N":["T205I"],"nsp13":["E341D"]},"labels":{"aa":"N: T205I; nsp13: E341D"}},"children":[{"name":"B.1.375","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.375"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.375"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.301671028137207}},"branch_attrs":{"mutations":{"nuc":["T1171C","A5747G","C10789T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G24007A","C25844T","A26664G"],"M":["I48V"],"ORF3a":["T151I"],"S":["H69-","V70-"],"nsp3":["T1010A"]},"labels":{"aa":"M: I48V; ORF3a: T151I; S: H69-, V70-; nsp3: T1010A","spike_mutations":"H69-, V70-"}}},{"name":"B.1.596.1","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.596.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.596.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["C21780T","G25907T","G28857A"],"N":["R195K"],"ORF3a":["G172V"],"S":["T73I"]},"labels":{"aa":"N: R195K; ORF3a: G172V; S: T73I","spike_mutations":"T73I"}}}]},{"name":"NODE_0000498","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.184943199157715}},"branch_attrs":{"mutations":{"nuc":["A23064C"],"S":["N501T"]},"labels":{"aa":"S: N501T","spike_mutations":"N501T"}},"children":[{"name":"B.1.517","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.517"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.517"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8103365898132324}},"branch_attrs":{"mutations":{"nuc":["G3231T","A12850G","C21364T","C28890T"],"N":["S206F"],"nsp16":["P236S"],"nsp3":["G171V"]},"labels":{"aa":"N: S206F; nsp16: P236S; nsp3: G171V"}}},{"name":"B.1.626","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.626"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.626"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G1914A","C2197T","C9142T","C9803T","C10416T","C10908T","G11222T","C13011T","C16961T","C21614T","C21758-","A21759-","T21760-","G21761-","C21762-","T21763-","A21764-","T21765-","A21766-","G22331A","G23012A","T23031C","C24138A","T24364C","C25511T","C25583T","T26767G","C27434T","A28271-","G28280T","C28887T","C29627T","C29738-","C29739-","A29740-","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-"],"M":["I82S"],"N":["D3Y","T205I"],"ORF10":["R24C"],"ORF3a":["S40L","T64I"],"ORF7a":["T14I"],"S":["L18F","H66-","A67-","I68-","G257S","E484K","F490S","T859N"],"nsp13":["P242L"],"nsp2":["R370H"],"nsp5":["S121L","A285V"],"nsp6":["V84F"],"nsp9":["T109I"]},"labels":{"aa":"M: I82S; N: D3Y, T205I; ORF10: R24C; ORF3a: S40L, T64I; ORF7a: T14I; S: L18F, H66-, A67-, I68-, G257S, E484K, F490S, T859N; nsp13: P242L; nsp2: R370H; nsp5: S121L, A285V; nsp6: V84F; nsp9: T109I","spike_mutations":"L18F, H66-, A67-, I68-, G257S, E484K, F490S, T859N"}}}]},{"name":"NODE_0000499","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.420584678649902}},"branch_attrs":{"mutations":{"nuc":["T9867C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C25517T","C27925T","A28271-"],"ORF3a":["P42L"],"ORF8":["T11I"],"nsp4":["L438P"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"ORF3a: P42L; ORF8: T11I; nsp4: L438P; nsp6: S106-, G107-, F108-"}},"children":[{"name":"B.1.526","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.526"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Iota"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21F (Iota)"},"partiallyAliased":{"value":"B.1.526"},"clade_nextstrain":{"value":"21F"},"clade_membership":{"value":"21F"},"placement_prior":{"value":-2.530679702758789}},"branch_attrs":{"mutations":{"nuc":["A16500C","A20262G","C21575T","C21846T","A22320G"],"S":["L5F","T95I","D253G"],"nsp13":["Q88H"]},"labels":{"aa":"S: L5F, T95I, D253G; nsp13: Q88H","clade":"Iota","spike_mutations":"L5F, T95I, D253G"}}},{"name":"B.1.637","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.637"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.637"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.0130152702331543}},"branch_attrs":{"mutations":{"nuc":["A9749G","C9891T","G11804A","A21801G","T21992-","A21993-","T21994-","T22032C","T22917G","C24138A","G24410C","G28044T","C28887T","G28975A"],"N":["T205I","M234I"],"ORF8":["A51S"],"S":["D80G","Y144-","F157S","L452R","T859N","D950H"],"nsp4":["K399E","A446V"],"nsp6":["V278I"]},"labels":{"aa":"N: T205I, M234I; ORF8: A51S; S: D80G, Y144-, F157S, L452R, T859N, D950H; nsp4: K399E, A446V; nsp6: V278I","spike_mutations":"D80G, Y144-, F157S, L452R, T859N, D950H"}}}]},{"name":"NODE_0000500","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.342108726501465}},"branch_attrs":{"mutations":{"nuc":["T22917G","C28887T"],"N":["T205I"],"S":["L452R"]},"labels":{"aa":"N: T205I; S: L452R","spike_mutations":"L452R"}},"children":[{"name":"B.1.630","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.630"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.630"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C629T","A1262G","C1627T","G4963T","A5040G","A5648C","C6730T","C6794T","C7768T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","T17505C","C19602T","G21255T","C21588T","C21637T","G21969T","T21992-","A21993-","T21994-","C22227T","G22289-","C22290-","T22291-","T22292-","T22293-","A22294-","C22995G","G23012C","C23525T","G24410A","C25498-","C25499-","G25500-","A25501-","T25502-","A25503-","C25504-","A25505-","A25506-","G25507-","C25508-","C25509-","T25510-","C25511-","A25512-","C25513-","T25514-","C25515-","C25516-","C25517-","T25518-","T25519-","T25520-","C25521-","T25563G","T27796C","C27889T","A28272G","C28512G","G29508A","C29739T"],"N":["P80R","S412N"],"ORF3a":["P36-","I37-","Q38-","A39-","S40-","L41-","P42-","F43-","H57Q"],"ORF7b":["L14S"],"ORF9b":["Q77E"],"S":["P9L","C136F","Y144-","A222V","L242-","A243-","T478R","E484Q","H655Y","D950N"],"nsp1":["L122F"],"nsp2":["T153A"],"nsp3":["R748S","Q774R","K977Q"],"nsp4":["A446V"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P80R, S412N; ORF3a: P36-, I37-, Q38-, A39-, S40-, L41-, P42-, F43-, H57Q; ORF7b: L14S; ORF9b: Q77E; S: P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N; nsp1: L122F; nsp2: T153A; nsp3: R748S, Q774R, K977Q; nsp4: A446V; nsp6: S106-, G107-, F108-","spike_mutations":"P9L, C136F, Y144-, A222V, L242-, A243-, T478R, E484Q, H655Y, D950N"}}},{"name":"21C","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_who":{"value":"Epsilon"},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["G17014T","G21600T","G22018T","C26681T","A28272T"],"S":["S13I","W152C"],"nsp13":["D260Y"]},"labels":{"aa":"S: S13I, W152C; nsp13: D260Y","clade":"Epsilon","spike_mutations":"S13I, W152C"}},"children":[{"name":"B.1.429","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.429"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Epsilon"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1.429"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-2.493906021118164}},"branch_attrs":{"mutations":{"nuc":["C2395T","T2597C","C8947T","C12100T","A12878G","T24349C","G27890T"],"nsp9":["I65V"]},"labels":{"aa":"nsp9: I65V"}}},{"name":"B.1.427","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.427"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Epsilon"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21C (Epsilon)"},"partiallyAliased":{"value":"B.1.427"},"clade_nextstrain":{"value":"21C"},"clade_membership":{"value":"21C"},"placement_prior":{"value":-2.8388147354125977}},"branch_attrs":{"mutations":{"nuc":["G9738C","G13713A","C16394T","C29362T"],"nsp13":["P53L"],"nsp4":["S395T"]},"labels":{"aa":"nsp13: P53L; nsp4: S395T"}}}]}]},{"name":"NODE_0000502","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-5.435559272766113}},"branch_attrs":{"mutations":{"nuc":["C6730T","T23042C","C23604A"],"S":["S494P","P681H"]},"labels":{"aa":"S: S494P, P681H","spike_mutations":"S494P, P681H"}},"children":[{"name":"B.1.623","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.623"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.623"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["T8704C","C9120T","C9870T","C11005A","C12854T","C13458T","G14559A","A23063T","G24893A","A27926-","A27927-","C27928-","T27929-","G27930-","T27931-","A27932-","G27933-","C27934-","T27935-","G27936-","C27937-","A27938-","T27939-","T27940-","T27941-","C27942-","A27943-","C27944-","C27945-","A27946-","A27947-","G27948-","A27949-","A27950-","T27951-","G27952-","T27953-","A27954-","G27955-","A28272T","G28975A"],"N":["M234I"],"ORF8":["T12-","V13-","A14-","A15-","F16-","H17-","Q18-","E19-","C20-","S21-"],"S":["N501Y","E1111K"],"nsp11":["S6L"],"nsp12":["S6L"],"nsp4":["T189I","T439M"],"nsp6":["H11Q"],"nsp9":["P57S"]},"labels":{"aa":"N: M234I; ORF8: T12-, V13-, A14-, A15-, F16-, H17-, Q18-, E19-, C20-, S21-; S: N501Y, E1111K; nsp11: S6L; nsp12: S6L; nsp4: T189I, T439M; nsp6: H11Q; nsp9: P57S","spike_mutations":"N501Y, E1111K"}}},{"name":"NODE_0000503","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.575"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8313353061676025}},"branch_attrs":{"mutations":{"nuc":["A1C","A1180G","C6936T","C10029T","C11514T","C16375T","T20748C","C23709T","T26767C","A28271-","C28887T","G29711-","C29719T"],"M":["I82T"],"N":["T205I"],"S":["T716I"],"nsp13":["P47S"],"nsp3":["S1406F"],"nsp4":["T492I"],"nsp6":["T181I"]},"labels":{"aa":"M: I82T; N: T205I; S: T716I; nsp13: P47S; nsp3: S1406F; nsp4: T492I; nsp6: T181I","spike_mutations":"T716I"}},"children":[{"name":"B.1.575","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.575"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8313353061676025}},"branch_attrs":{"mutations":{}}},{"name":"B.1.575.1","node_attrs":{"div":22,"Nextclade_pango":{"value":"B.1.575.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":14},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.575.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.6448798179626465}},"branch_attrs":{"mutations":{"nuc":["G29513T","C29614T"],"N":["A414S"]},"labels":{"aa":"N: A414S"}}}]}]},{"name":"NODE_0000504","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.8868496417999268}},"branch_attrs":{"mutations":{"nuc":["G174T","G5230T","A10323G","A21801C","A22206G","T22283-","T22284-","A22285-","C22286-","T22287-","T22288-","G22289-","C22290-","T22291-","G22813T","G23012A","A23063T","C23664T","C26456T","C28253T","C28887T"],"E":["P71L"],"N":["T205I"],"S":["D80A","D215G","L241-","L242-","A243-","K417N","E484K","N501Y","A701V"],"nsp3":["K837N"],"nsp5":["K90R"]},"labels":{"aa":"E: P71L; N: T205I; S: D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V; nsp3: K837N; nsp5: K90R","clade":"Beta","spike_mutations":"D80A, D215G, L241-, L242-, A243-, K417N, E484K, N501Y, A701V"}},"children":[{"name":"B.1.351.1","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.351.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.1"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-5.4324798583984375}},"branch_attrs":{"mutations":{"nuc":["C11289G","G11291T","G11292A","T11293C","G11299T","C11300T","T11301A","A11302C","C22513A"],"S":["N317K"],"nsp6":["S106C","G107Y","K109N","L110Y"]},"labels":{"aa":"S: N317K; nsp6: S106C, G107Y, K109N, L110Y","spike_mutations":"N317K"}}},{"name":"NODE_0000505","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.2380783557891846}},"branch_attrs":{"mutations":{"nuc":["C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}},"children":[{"name":"B.1.351","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.351"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.2380783557891846}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000506","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-2.969865322113037}},"branch_attrs":{"mutations":{"nuc":["A2692T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C21614T"],"S":["L18F"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"S: L18F; nsp6: S106-, G107-, F108-","spike_mutations":"L18F"}},"children":[{"name":"B.1.351.5","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.351.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.5"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-4.056199073791504}},"branch_attrs":{"mutations":{"nuc":["C664T","G1463T","C16338T","C19019A","C24109T","C24334T","G25660A","C25844T","C26645T","A29406T"],"N":["E378V"],"ORF3a":["V90I","T151I"],"nsp14":["P327Q"],"nsp2":["G220C"]},"labels":{"aa":"N: E378V; ORF3a: V90I, T151I; nsp14: P327Q; nsp2: G220C"}}},{"name":"NODE_0000507","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.351"},"clade_who":{"value":"Beta"},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A8052G","G10396T"],"nsp3":["N1778S"]},"labels":{"aa":"nsp3: N1778S"}},"children":[{"name":"B.1.351.2","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.351.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.2"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C10632T"],"nsp5":["A193V"]},"labels":{"aa":"nsp5: A193V"}}},{"name":"B.1.351.3","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.351.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Beta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20H (Beta)"},"partiallyAliased":{"value":"B.1.351.3"},"clade_nextstrain":{"value":"20H"},"clade_membership":{"value":"20H"},"placement_prior":{"value":-4.018410682678223}},"branch_attrs":{"mutations":{"nuc":["T3G","C6402T","T7624C","C10615T","A16687G"],"nsp13":["I151V"],"nsp3":["P1228L"]},"labels":{"aa":"nsp13: I151V; nsp3: P1228L"}}}]}]}]}]},{"name":"NODE_0000508","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.577651023864746}},"branch_attrs":{"mutations":{"nuc":["A10323G","G28842T"],"N":["S190I"],"nsp5":["K90R"]},"labels":{"aa":"N: S190I; nsp5: K90R"}},"children":[{"name":"B.1.361","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.361"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.361"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.086843013763428}},"branch_attrs":{"mutations":{"nuc":["A705G","G1463A","G11417T","C18167T","A21080G","G29779T"],"nsp1":["D147G"],"nsp14":["P43L"],"nsp16":["K141R"],"nsp2":["G220S"],"nsp6":["V149F"]},"labels":{"aa":"nsp1: D147G; nsp14: P43L; nsp16: K141R; nsp2: G220S; nsp6: V149F"}}},{"name":"B.1.580","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.580"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.580"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.577651023864746}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000509","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{"nuc":["T15276A"]}},"children":[{"name":"B.1.568","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.568"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.568"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.0975661277771}},"branch_attrs":{"mutations":{"nuc":["C5654T","C10450T","C12049T","C12455A","C16428T","C17483T","G25913A","G27916T"],"ORF3a":["G174D"],"ORF8":["G8V"],"nsp13":["T416I"],"nsp8":["L122I"]},"labels":{"aa":"ORF3a: G174D; ORF8: G8V; nsp13: T416I; nsp8: L122I"}}},{"name":"B.1.582","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.582"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.582"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{}}},{"name":"B.1.612","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.612"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.612"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.187291622161865}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000510","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.043567180633545}},"branch_attrs":{"mutations":{"nuc":["C11916T"],"nsp7":["S25L"]},"labels":{"aa":"nsp7: S25L"}},"children":[{"name":"B.1.3","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.3"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C715T","A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"B.1.497","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.497"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.497"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A1G","C16650T","A20675T","G29179T"],"nsp16":["Q6L"]},"labels":{"aa":"nsp16: Q6L"}}},{"name":"B.1.509","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.509"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.509"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.097189426422119}},"branch_attrs":{"mutations":{"nuc":["C1385T","G1738T","G3242A","C28087T"],"ORF8":["A65V"],"nsp2":["H194Y"],"nsp3":["G175S"]},"labels":{"aa":"ORF8: A65V; nsp2: H194Y; nsp3: G175S"}}},{"name":"NODE_0000511","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8577680587768555}},"branch_attrs":{"mutations":{"nuc":["C18998T","G29540A"],"nsp14":["A320V"]},"labels":{"aa":"nsp14: A320V"}},"children":[{"name":"B.1.499","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.499"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.499"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["C28863T"],"N":["S197L"]},"labels":{"aa":"N: S197L"}}},{"name":"B.1.503","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.503"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.503"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25947C"],"ORF3a":["Q185H"]},"labels":{"aa":"ORF3a: Q185H"}}},{"name":"B.1.505","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.505"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.505"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C66A","C7768T","A8773G","C17304T","T24805C"]}}}]}]},{"name":"NODE_0000512","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.3401401042938232}},"branch_attrs":{"mutations":{"nuc":["C27964T"],"ORF8":["S24L"]},"labels":{"aa":"ORF8: S24L"}},"children":[{"name":"B.1.265","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.265"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.265"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.231685638427734}},"branch_attrs":{"mutations":{"nuc":["C28833T"],"N":["S187L"]},"labels":{"aa":"N: S187L"}}},{"name":"B.1.336","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.336"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.336"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.561881065368652}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}}},{"name":"B.1.426","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.426"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.426"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8296751976013184}},"branch_attrs":{"mutations":{"nuc":["T833C","A22320G"],"S":["D253G"],"nsp2":["F10L"]},"labels":{"aa":"S: D253G; nsp2: F10L","spike_mutations":"D253G"}}},{"name":"NODE_0000513","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.462985992431641}},"branch_attrs":{"mutations":{"nuc":["A18424G","G25907T"],"ORF3a":["G172V"],"nsp14":["N129D"]},"labels":{"aa":"ORF3a: G172V; nsp14: N129D"}},"children":[{"name":"B.1.2","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20G"},"partiallyAliased":{"value":"B.1.2"},"clade_nextstrain":{"value":"20G"},"clade_membership":{"value":"20G"},"placement_prior":{"value":-2.0290451049804688}},"branch_attrs":{"mutations":{"nuc":["C10319T","C21304T","C28472T","C28869T"],"N":["P67S","P199L"],"nsp16":["R216C"],"nsp5":["L89F"]},"labels":{"aa":"N: P67S, P199L; nsp16: R216C; nsp5: L89F","clade":"20G"}}},{"name":"B.1.596","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.596"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.596"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.462985992431641}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000514","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7341673374176025}},"branch_attrs":{"mutations":{"nuc":["C10319T"],"nsp5":["L89F"]},"labels":{"aa":"nsp5: L89F"}},"children":[{"name":"B.1.567","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.567"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.567"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.657742500305176}},"branch_attrs":{"mutations":{"nuc":["C11575T","A20262G","G21305A","C28868T"],"N":["P199S"],"nsp16":["R216H"]},"labels":{"aa":"N: P199S; nsp16: R216H"}}},{"name":"B.1.577","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.577"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.577"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.8689005374908447}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"nsp13":["T153I"]},"labels":{"aa":"nsp13: T153I"}}},{"name":"B.1.595","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.595"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.595"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-3.7341673374176025}},"branch_attrs":{"mutations":{"nuc":["A1G"]}}},{"name":"NODE_0000515","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1"},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.714270114898682}},"branch_attrs":{"mutations":{"nuc":["G6052A","G19872T","G25855T","G29254T","G29474T"],"N":["D401Y"],"ORF3a":["D155Y"]},"labels":{"aa":"N: D401Y; ORF3a: D155Y"}},"children":[{"name":"B.1.587","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.587"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.587"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.290242671966553}},"branch_attrs":{"mutations":{"nuc":["T5122C","G20102T","C20117T","A22095G"],"S":["D178G"],"nsp15":["S161I","T166I"]},"labels":{"aa":"S: D178G; nsp15: S161I, T166I","spike_mutations":"D178G"}}},{"name":"B.1.588","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.588"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20C"},"partiallyAliased":{"value":"B.1.588"},"clade_nextstrain":{"value":"20C"},"clade_membership":{"value":"20C"},"placement_prior":{"value":-4.000661373138428}},"branch_attrs":{"mutations":{"nuc":["C7600T","G7675C","C21621T","G22201T","G28975T","G29764T"],"N":["M234I"],"S":["T20I"]},"labels":{"aa":"N: M234I; S: T20I","spike_mutations":"T20I"}}}]}]}]}]},{"name":"NODE_0000516","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.617"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-3.895909309387207}},"branch_attrs":{"mutations":{"nuc":["G210T","T22917G","C23604G","T27638C","G28881T","G29402T","G29742T"],"N":["R203M","D377Y"],"ORF7a":["V82A"],"S":["T19R","L452R","P681R"]},"labels":{"aa":"N: R203M, D377Y; ORF7a: V82A; S: T19R, L452R, P681R","spike_mutations":"T19R, L452R, P681R"}},"children":[{"name":"B.1.617.3","node_attrs":{"div":22,"Nextclade_pango":{"value":"B.1.617.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617.3"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["C835T","C7296T","C8208T","G10634T","C11322T","C16293T","C21618G","G23012C","T27384C","C27970T","C28472T"],"N":["P67S"],"ORF8":["T26I"],"S":["E484Q"],"nsp3":["A1526V","T1830I"],"nsp5":["A194S"],"nsp6":["A117V"]},"labels":{"aa":"N: P67S; ORF8: T26I; S: E484Q; nsp3: A1526V, T1830I; nsp5: A194S; nsp6: A117V","spike_mutations":"E484Q"}}},{"name":"internal_d736","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.617"},"clade_display":{"value":"20A"},"partiallyAliased":{"value":"B.1.617"},"clade_nextstrain":{"value":"20A"},"clade_membership":{"value":"20A"},"placement_prior":{"value":-4.2567901611328125}},"branch_attrs":{"mutations":{"nuc":["G21987A","C25469T"],"ORF3a":["S26L"],"S":["G142D"]},"labels":{"aa":"ORF3a: S26L; S: G142D","spike_mutations":"G142D"}},"children":[{"name":"B.1.617.1","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.617.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Kappa"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21B (Kappa)"},"partiallyAliased":{"value":"B.1.617.1"},"clade_nextstrain":{"value":"21B"},"clade_membership":{"value":"21B"},"placement_prior":{"value":-3.281346321105957}},"branch_attrs":{"mutations":{"nuc":["C3457T","C4965T","A11201G","G17523T","A20396G","T21895C","G22022A","G23012C","C26681T","T26767G"],"M":["I82S"],"S":["R19T","E154K","E484Q"],"nsp13":["M429I"],"nsp15":["K259R"],"nsp3":["T749I"],"nsp6":["T77A"]},"labels":{"aa":"M: I82S; S: R19T, E154K, E484Q; nsp13: M429I; nsp15: K259R; nsp3: T749I; nsp6: T77A","clade":"Kappa","spike_mutations":"R19T, E154K, E484Q"}}},{"name":"NODE_0000518","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.928345203399658}},"branch_attrs":{"mutations":{"nuc":["C21618G","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","C22995A","G24410A","T26767C","C27752T","A28271-","A28461G"],"M":["I82T"],"N":["D63G"],"ORF7a":["T120I"],"ORF9b":["T60A"],"S":["E156-","F157-","R158G","T478K","D950N"]},"labels":{"aa":"M: I82T; N: D63G; ORF7a: T120I; ORF9b: T60A; S: E156-, F157-, R158G, T478K, D950N","clade":"Delta","spike_mutations":"E156-, F157-, R158G, T478K, D950N"}},"children":[{"name":"NODE_0000519","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.125234365463257}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","C5184T","G9203A","T9678C","C11005A","A17496G","A20396G","A21792C","C28253T"],"S":["K77T"],"nsp15":["K259R"],"nsp2":["P129L"],"nsp3":["P822L"],"nsp4":["D217N","F375S"],"nsp6":["H11Q"]},"labels":{"aa":"S: K77T; nsp15: K259R; nsp2: P129L; nsp3: P822L; nsp4: D217N, F375S; nsp6: H11Q","spike_mutations":"K77T"}},"children":[{"name":"AY.35","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.35"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.42242431640625}},"branch_attrs":{"mutations":{"nuc":["A1C","C6027A","C13989T","C16915T","G23012C"],"S":["E484Q"],"nsp3":["P1103Q"]},"labels":{"aa":"S: E484Q; nsp3: P1103Q","spike_mutations":"E484Q"}}},{"name":"AY.48","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.48"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.48"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A10399G","C10868T","G27948T"],"ORF8":["E19*"]},"labels":{"aa":"ORF8: E19*"}}}]},{"name":"NODE_0000520","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.281507730484009}},"branch_attrs":{"mutations":{"nuc":["G15451A","C16466T"],"nsp12":["G671S"],"nsp13":["P77L"]},"labels":{"aa":"nsp12: G671S; nsp13: P77L"}},"children":[{"name":"B.1.617.2","node_attrs":{"div":21,"Nextclade_pango":{"value":"B.1.617.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.281507730484009}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000521","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.9130396842956543}},"branch_attrs":{"mutations":{"nuc":["C5184T","C9891T","T11418C","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-"],"ORF8":["D119-","F120-"],"nsp3":["P822L"],"nsp4":["A446V"],"nsp6":["V149A"]},"labels":{"aa":"ORF8: D119-, F120-; nsp3: P822L; nsp4: A446V; nsp6: V149A"}},"children":[{"name":"NODE_0000522","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.995262622833252}},"branch_attrs":{"mutations":{"nuc":["C1191T","C1267T","T12946C","A20262G","C27739T"],"ORF7a":["L116F"],"nsp2":["P129L"]},"labels":{"aa":"ORF7a: L116F; nsp2: P129L"}},"children":[{"name":"NODE_0000523","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.093592882156372}},"branch_attrs":{"mutations":{"nuc":["C6539T","C20320T","C24745T","G28690T","G29427A"],"N":["L139F","R385K"],"nsp15":["H234Y"],"nsp3":["H1274Y"]},"labels":{"aa":"N: L139F, R385K; nsp15: H234Y; nsp3: H1274Y"}},"children":[{"name":"AY.30","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.30"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.30"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.6562893390655518}},"branch_attrs":{"mutations":{"nuc":["C9319T","A13482G","-28271A","G29781T"]}}},{"name":"AY.40","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.40"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.40"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["A1558G","C1912T","G2755T","A15892G","G23282T","C28099T","T28297C"],"ORF8":["S69L"],"ORF9b":["I5T"],"S":["D574Y"],"nsp12":["M818V"],"nsp2":["I251M"]},"labels":{"aa":"ORF8: S69L; ORF9b: I5T; S: D574Y; nsp12: M818V; nsp2: I251M","spike_mutations":"D574Y"}}}]},{"name":"NODE_0000524","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.395604133605957}},"branch_attrs":{"mutations":{"nuc":["C18176T"],"nsp14":["P46L"]},"labels":{"aa":"nsp14: P46L"}},"children":[{"name":"AY.49","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.49"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF3a:30-276"},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.frameShifts":{"value":"ORF3a:30-276"},"qc.frameShifts.totalFrameShifts":{"value":1},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.49"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T5773C","C10834T","C23039G","G24124T","G25471-","A25472-","T25473-","T25474-","T25475-","T25476-","G25477-","T25478-","C26110T","A27979T"],"ORF3a":["L26-","D27-","F28-","V29-"],"ORF8":["Q29L"],"S":["Q493E","K854N"]},"labels":{"aa":"ORF3a: L26-, D27-, F28-, V29-; ORF8: Q29L; S: Q493E, K854N","spike_mutations":"Q493E, K854N"}}},{"name":"AY.50","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.50"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.50"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C884T","C5730T","C19554T","G22484C","-28271A","G28809T"],"N":["G179V"],"S":["V308L"],"nsp2":["R27C"],"nsp3":["T1004I"]},"labels":{"aa":"N: G179V; S: V308L; nsp2: R27C; nsp3: T1004I","spike_mutations":"V308L"}}},{"name":"AY.53","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.53"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.53"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.5879409313201904}},"branch_attrs":{"mutations":{"nuc":["G1738T","A2292C","C18348T","C20031T","G21641T"],"S":["A27S"],"nsp2":["Q496P"]},"labels":{"aa":"S: A27S; nsp2: Q496P","spike_mutations":"A27S"}}},{"name":"AY.52","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.52"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.52"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["T24984G","T25689C","G26428T","C26858T","C28419T"],"E":["V62F"],"N":["T49I"],"S":["L1141W"]},"labels":{"aa":"E: V62F; N: T49I; S: L1141W","spike_mutations":"L1141W"}}},{"name":"AY.8","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.8"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.8487331867218018}},"branch_attrs":{"mutations":{"nuc":["C11455T","A14170G"],"nsp12":["I244V"]},"labels":{"aa":"nsp12: I244V"}}},{"name":"NODE_0000525","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.849754571914673}},"branch_attrs":{"mutations":{"nuc":["A18468G"]}},"children":[{"name":"AY.13","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.13"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.3170342445373535}},"branch_attrs":{"mutations":{"nuc":["A17406G","C29095T"]}}},{"name":"NODE_0000526","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.16"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{"nuc":["T26076A"]}},"children":[{"name":"AY.16.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16.1"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C8407T","A12417G","G12911A","C14913T","T29867A"],"nsp8":["N109S"],"nsp9":["V76I"]},"labels":{"aa":"nsp8: N109S; nsp9: V76I"}}},{"name":"AY.16","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.16"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.143013954162598}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000527","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.429879188537598}},"branch_attrs":{"mutations":{"nuc":["C19160T"],"nsp14":["S374F"]},"labels":{"aa":"nsp14: S374F"}},"children":[{"name":"AY.14","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.14"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.0154049396514893}},"branch_attrs":{"mutations":{"nuc":["T1877G","G20718T"],"nsp16":["M20I"],"nsp2":["S358A"]},"labels":{"aa":"nsp16: M20I; nsp2: S358A"}}},{"name":"AY.15","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.15"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.385550022125244}},"branch_attrs":{"mutations":{"nuc":["A16872G","G27382C","-28271A"],"ORF6":["D61H"]},"labels":{"aa":"ORF6: D61H"}}},{"name":"AY.54","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.54"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.54"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-3.0774950981140137}},"branch_attrs":{"mutations":{"nuc":["A1G","C193T","G14187A","A25806G"]}}}]},{"name":"NODE_0000528","node_attrs":{"div":31,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.0211334228515625}},"branch_attrs":{"mutations":{"nuc":["A25562G"],"ORF3a":["Q57R"]},"labels":{"aa":"ORF3a: Q57R"}},"children":[{"name":"AY.19","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.19"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.19"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G25019T","G25947T","-28271A"],"ORF3a":["Q185H"],"S":["D1153Y"]},"labels":{"aa":"ORF3a: Q185H; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"AY.17","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.17"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2240G","C14708T","C17436T","-28271A"],"nsp12":["A423V"],"nsp2":["I479V"]},"labels":{"aa":"nsp12: A423V; nsp2: I479V"}}},{"name":"AY.51","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.51"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21A (Delta)"},"partiallyAliased":{"value":"B.1.617.2.51"},"clade_nextstrain":{"value":"21A"},"clade_membership":{"value":"21A"},"placement_prior":{"value":-4.137358665466309}},"branch_attrs":{"mutations":{"nuc":["G12223T","A25697T"],"ORF3a":["E102V"]},"labels":{"aa":"ORF3a: E102V"}}}]}]}]},{"name":"NODE_0000529","node_attrs":{"div":26,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6166188716888428}},"branch_attrs":{"mutations":{"nuc":["C11514T","C22227T"],"S":["A222V"],"nsp6":["T181I"]},"labels":{"aa":"S: A222V; nsp6: T181I","clade":"21I","spike_mutations":"A222V"}},"children":[{"name":"AY.62","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.62"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.62"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["A1045T","G1820A","A20085G","C28093T","G29440A"],"ORF8":["S67F"],"nsp2":["G339S"]},"labels":{"aa":"ORF8: S67F; nsp2: G339S"}}},{"name":"NODE_0000530","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6697630882263184}},"branch_attrs":{"mutations":{"nuc":["A5584G"]}},"children":[{"name":"AY.24","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.24"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.24"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.5928659439086914}},"branch_attrs":{"mutations":{"nuc":["C23896T","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"NODE_0000531","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.90034556388855}},"branch_attrs":{"mutations":{"nuc":["C13019T"]}},"children":[{"name":"AY.10","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.10"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.07296895980835}},"branch_attrs":{"mutations":{"nuc":["G219T","A8651G","G9526T","C12756T","C13665T","A23734G"],"nsp4":["M33V","M324I"],"nsp9":["T24I"]},"labels":{"aa":"nsp4: M33V, M324I; nsp9: T24I"}}},{"name":"AY.11","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.11"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.418825149536133}},"branch_attrs":{"mutations":{"nuc":["C3486T","C18526T","T19516C","G26526T","C29509T"],"M":["A2S"],"nsp14":["R163C"],"nsp3":["A256V"]},"labels":{"aa":"M: A2S; nsp14: R163C; nsp3: A256V"}}},{"name":"AY.28","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.28"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.28"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C335T","G2167T","C8950T","C9246T","G23663T","G24794T","G25855T"],"ORF3a":["D155Y"],"S":["A701S","A1078S"],"nsp1":["R24C"],"nsp2":["K454N"],"nsp4":["A231V"]},"labels":{"aa":"ORF3a: D155Y; S: A701S, A1078S; nsp1: R24C; nsp2: K454N; nsp4: A231V","spike_mutations":"A701S, A1078S"}}},{"name":"AY.27","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.27"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.27"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.8427717685699463}},"branch_attrs":{"mutations":{"nuc":["T11938C","A14475G","G29422T"]}}},{"name":"AY.47","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.47"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.47"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.620307445526123}},"branch_attrs":{"mutations":{"nuc":["C1684T","G5164T","C12049T","G22427A","G28326T"],"N":["G18V"],"ORF9b":["V15L"],"S":["V289I"],"nsp3":["E815D"]},"labels":{"aa":"N: G18V; ORF9b: V15L; S: V289I; nsp3: E815D","spike_mutations":"V289I"}}},{"name":"AY.55","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.55"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.55"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.71439266204834}},"branch_attrs":{"mutations":{"nuc":["A10978G","-28271A"]}}},{"name":"AY.57","node_attrs":{"div":30,"Nextclade_pango":{"value":"AY.57"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.57"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.764986515045166}},"branch_attrs":{"mutations":{"nuc":["C1403T","G5584T"],"nsp2":["P200S"]},"labels":{"aa":"nsp2: P200S"}}},{"name":"AY.56","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.56"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.56"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C3634T","C25624T","G27870T"],"ORF3a":["H78Y"],"ORF7b":["E39*"]},"labels":{"aa":"ORF3a: H78Y; ORF7b: E39*"}}},{"name":"AY.59","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.59"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.59"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6204702854156494}},"branch_attrs":{"mutations":{"nuc":["C19164T","T20391G","C21302T"],"nsp16":["P215L"]},"labels":{"aa":"nsp16: P215L"}}},{"name":"AY.61","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.61"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.61"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.942255735397339}},"branch_attrs":{"mutations":{"nuc":["T25532C"],"ORF3a":["I47T"]},"labels":{"aa":"ORF3a: I47T"}}},{"name":"AY.60","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.60"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.60"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["A2165C","C2919T","G4162T","T8634C","T12056A","T13701C","G17122T"],"nsp13":["A296S"],"nsp2":["K454Q"],"nsp3":["P67L"],"nsp4":["I27T"],"nsp7":["C72S"]},"labels":{"aa":"nsp13: A296S; nsp2: K454Q; nsp3: P67L; nsp4: I27T; nsp7: C72S"}}},{"name":"AY.64","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.64"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.64"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.9437766075134277}},"branch_attrs":{"mutations":{"nuc":["T2C","C346T","C5784T","C6388T","C24130T","G25135T","G25691T","C27005T","G29254T","G29688T"],"ORF3a":["G100V"],"S":["K1191N"],"nsp3":["T1022I"]},"labels":{"aa":"ORF3a: G100V; S: K1191N; nsp3: T1022I","spike_mutations":"K1191N"}}},{"name":"AY.68","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.68"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.68"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.760132312774658}},"branch_attrs":{"mutations":{"nuc":["G105T","C3294T","C8208T","C14362T","C19524T","A22320C","T24499A","C25782T","A26891G","T27878C"],"S":["D253A","D979E"],"nsp3":["P192L","T1830I"]},"labels":{"aa":"S: D253A, D979E; nsp3: P192L, T1830I","spike_mutations":"D253A, D979E"}}},{"name":"AY.67","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.67"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.67"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8576669692993164}},"branch_attrs":{"mutations":{"nuc":["C4890T","T5644C","T19519C","A27368G"],"ORF6":["Q56R"],"nsp14":["Y494H"],"nsp3":["T724I"]},"labels":{"aa":"ORF6: Q56R; nsp14: Y494H; nsp3: T724I"}}},{"name":"AY.66","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.66"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.66"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["T13C","T6496C","G14874T","C28892T"],"N":["P207S"],"nsp12":["K478N"]},"labels":{"aa":"N: P207S; nsp12: K478N"}}},{"name":"AY.69","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.69"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.69"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C3984T","A4405T","A4838G","G9431A","G16864A","G17847A","G25720T","C27559T"],"ORF3a":["A110S"],"nsp13":["V210I"],"nsp3":["T422I","I707V"],"nsp4":["V293I"]},"labels":{"aa":"ORF3a: A110S; nsp13: V210I; nsp3: T422I, I707V; nsp4: V293I"}}},{"name":"AY.70","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.70"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.70"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.4444901943206787}},"branch_attrs":{"mutations":{"nuc":["C4891T","G21255T","G21624C","G28899T","G28903T"],"N":["R209I","M210I"],"S":["R21T"]},"labels":{"aa":"N: R209I, M210I; S: R21T","spike_mutations":"R21T"}}},{"name":"NODE_0000532","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.80359411239624}},"branch_attrs":{"mutations":{"nuc":["C5192T"]}},"children":[{"name":"AY.58","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.58"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.58"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1433491706848145}},"branch_attrs":{"mutations":{"nuc":["G8540A","C26079A","C27131T"],"nsp3":["A1941T"]},"labels":{"aa":"nsp3: A1941T"}}},{"name":"AY.63","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.63"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.63"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.740610122680664}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","A7886G","C8964T","C9857T","C13335T","A14246G","A19126G","A23848G","C25710T","G29616T","T29728C"],"ORF10":["R20I"],"nsp1":["K141-","S142-","F143-"],"nsp10":["A104V"],"nsp12":["D269G"],"nsp14":["I363V"],"nsp3":["I1723V"],"nsp4":["S137L"]},"labels":{"aa":"ORF10: R20I; nsp1: K141-, S142-, F143-; nsp10: A104V; nsp12: D269G; nsp14: I363V; nsp3: I1723V; nsp4: S137L"}}}]},{"name":"NODE_0000533","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.75"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1813862323760986}},"branch_attrs":{"mutations":{"nuc":["C21622T"]}},"children":[{"name":"AY.75","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.75"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1813862323760986}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000534","node_attrs":{"div":30,"Nextclade_pango":{"value":"AY.75"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.644587278366089}},"branch_attrs":{"mutations":{"nuc":["G29744A"]}},"children":[{"name":"AY.75.2","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.75.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T13C","T7717C","A16824G","A21987G","G23611T"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}}},{"name":"AY.75.3","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.75.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.75.3"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T322C","C1329A","G8428A","G16873A","T19127C","C22314T"],"S":["P251L"],"nsp13":["G213S"],"nsp14":["I363T"],"nsp2":["T175N"]},"labels":{"aa":"S: P251L; nsp13: G213S; nsp14: I363T; nsp2: T175N","spike_mutations":"P251L"}}}]}]},{"name":"NODE_0000535","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.9"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.33573317527771}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"AY.9","node_attrs":{"div":29,"Nextclade_pango":{"value":"AY.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.33573317527771}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000536","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.9.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.80546498298645}},"branch_attrs":{"mutations":{"nuc":["G1729A","G14030A","C18086T"],"nsp12":["R197Q"],"nsp14":["T16I"]},"labels":{"aa":"nsp12: R197Q; nsp14: T16I"}},"children":[{"name":"AY.9.2.2","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.9.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6840121746063232}},"branch_attrs":{"mutations":{"nuc":["C4321T","A9685G","C23585A"],"S":["Q675K"],"nsp4":["I377M"]},"labels":{"aa":"S: Q675K; nsp4: I377M","spike_mutations":"Q675K"}}},{"name":"AY.9.2","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.9.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.80546498298645}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000537","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-2.977773427963257}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"AY.133","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.133"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.133"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["C203T","C449T","C4763T","C12025T","C20104T","T21613A","C21614T","C23058G","C24370T","T25333C","T29867A"],"S":["N17K","L18F","P499R"],"nsp1":["P62S"],"nsp15":["L162F"],"nsp3":["H682Y"]},"labels":{"aa":"S: N17K, L18F, P499R; nsp1: P62S; nsp15: L162F; nsp3: H682Y","spike_mutations":"N17K, L18F, P499R"}}},{"name":"NODE_0000538","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-5.0027546882629395}},"branch_attrs":{"mutations":{"nuc":["T13019C"]}},"children":[{"name":"AY.65","node_attrs":{"div":32,"Nextclade_pango":{"value":"AY.65"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:121-122"},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.65"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G14028T","C27005T","-28253T","-28271A"],"nsp12":["M196I"]},"labels":{"aa":"nsp12: M196I"}}},{"name":"NODE_0000539","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.26"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.016456365585327}},"branch_attrs":{"mutations":{"nuc":["A27345T"],"ORF6":["K48N"]},"labels":{"aa":"ORF6: K48N"}},"children":[{"name":"AY.26","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.26"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.016456365585327}},"branch_attrs":{"mutations":{}}},{"name":"AY.26.1","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.26.1"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G20580T","A21987G","G23012C","A24587T","G26529C","G27703T","C29769T"],"M":["D3H"],"ORF7a":["V104F"],"S":["D142G","E484Q","T1009S"]},"labels":{"aa":"M: D3H; ORF7a: V104F; S: D142G, E484Q, T1009S","spike_mutations":"D142G, E484Q, T1009S"}}}]}]}]},{"name":"NODE_0000540","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.1191558837890625}},"branch_attrs":{"mutations":{"nuc":["C2509T"]}},"children":[{"name":"AY.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6743457317352295}},"branch_attrs":{"mutations":{"nuc":["A1G","T3055C","G3701A","C17336T","C18570T","G21770T","G22813T","T29867A","G29868A"],"S":["V70F","K417N"],"nsp13":["T367I"],"nsp3":["A328T"]},"labels":{"aa":"S: V70F, K417N; nsp13: T367I; nsp3: A328T","spike_mutations":"V70F, K417N"}}},{"name":"AY.37","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.37"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.37"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.6478559970855713}},"branch_attrs":{"mutations":{"nuc":["G2185T","T20911C"],"nsp2":["E460D"]},"labels":{"aa":"nsp2: E460D"}}},{"name":"AY.38","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.38"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.963697910308838}},"branch_attrs":{"mutations":{"nuc":["G15760T","A22310T","-28271A","G29212T","T29742G"],"S":["T250S"],"nsp12":["G774C"]},"labels":{"aa":"S: T250S; nsp12: G774C","spike_mutations":"T250S"}}},{"name":"AY.71","node_attrs":{"div":31,"Nextclade_pango":{"value":"AY.71"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.71"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.8321352005004883}},"branch_attrs":{"mutations":{"nuc":["A1T","C25317T","-28271A"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"NODE_0000541","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.954825401306152}},"branch_attrs":{"mutations":{"nuc":["G5539A"]}},"children":[{"name":"AY.73","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.73"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":27},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.73"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.9488861560821533}},"branch_attrs":{"mutations":{"nuc":["C222T","C6573T","C27657T","C28409T","C28893T"],"N":["P46S","P207L"],"nsp3":["S1285F"]},"labels":{"aa":"N: P46S, P207L; nsp3: S1285F"}}},{"name":"AY.72","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.72"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.72"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-4.11883020401001}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G6080T","A25856G","C26013T"],"ORF3a":["D155G"],"nsp1":["K141-","S142-","F143-"],"nsp3":["D1121Y"]},"labels":{"aa":"ORF3a: D155G; nsp1: K141-, S142-, F143-; nsp3: D1121Y"}}},{"name":"AY.74","node_attrs":{"div":33,"Nextclade_pango":{"value":"AY.74"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21I (Delta)"},"partiallyAliased":{"value":"B.1.617.2.74"},"clade_nextstrain":{"value":"21I"},"clade_membership":{"value":"21I"},"placement_prior":{"value":-3.1409428119659424}},"branch_attrs":{"mutations":{"nuc":["G3994A","C25413T","G29392T"],"N":["K373N"]},"labels":{"aa":"N: K373N"}}}]}]}]}]}]}]},{"name":"NODE_0000542","node_attrs":{"div":32,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1918766498565674}},"branch_attrs":{"mutations":{"nuc":["G4181T","C6402T","C7124T","C8986T","C10029T","A11201G","A11332G","C19220T","C21846T","C27874T","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","G28916T"],"N":["G215C"],"ORF7b":["T40I"],"ORF8":["D119-","F120-"],"S":["T95I"],"nsp14":["A394V"],"nsp3":["A488S","P1228L","P1469S"],"nsp4":["T492I"],"nsp6":["T77A"]},"labels":{"aa":"N: G215C; ORF7b: T40I; ORF8: D119-, F120-; S: T95I; nsp14: A394V; nsp3: A488S, P1228L, P1469S; nsp4: T492I; nsp6: T77A","clade":"21J","spike_mutations":"T95I"}},"children":[{"name":"AY.78","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.78"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.78"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.552331924438477}},"branch_attrs":{"mutations":{"nuc":["T13188C","G14874T","G15372T","-28271A","C29200T","G29227A"],"nsp10":["I55T"],"nsp12":["K478N"]},"labels":{"aa":"nsp10: I55T; nsp12: K478N"}}},{"name":"NODE_0000543","node_attrs":{"div":33,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.0917282104492188}},"branch_attrs":{"mutations":{"nuc":["G9053T"],"nsp4":["V167L"]},"labels":{"aa":"nsp4: V167L"}},"children":[{"name":"AY.1","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5589118003845215}},"branch_attrs":{"mutations":{"nuc":["G22335T","G22813T"],"S":["W258L","K417N"]},"labels":{"aa":"S: W258L, K417N","spike_mutations":"W258L, K417N"}}},{"name":"AY.105","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.105"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.105"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.082991123199463}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2939T"],"nsp3":["P74S"]},"labels":{"aa":"nsp3: P74S"}}},{"name":"AY.106","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.106"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.106"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6580145359039307}},"branch_attrs":{"mutations":{"nuc":["C9811T","C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"AY.109","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.109"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.109"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6555285453796387}},"branch_attrs":{"mutations":{"nuc":["A11595G","A14836G","T21846C","C27549T"],"S":["I95T"],"nsp12":["I466V"],"nsp6":["Q208R"]},"labels":{"aa":"S: I95T; nsp12: I466V; nsp6: Q208R","spike_mutations":"I95T"}}},{"name":"AY.107","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.107"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.107"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4870200157165527}},"branch_attrs":{"mutations":{"nuc":["A15012G","C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"AY.110","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.110"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":7},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.110"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.568274736404419}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","C912A"],"nsp1":["K141-","S142-","F143-"],"nsp2":["S36Y"]},"labels":{"aa":"nsp1: K141-, S142-, F143-; nsp2: S36Y"}}},{"name":"AY.112","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.112"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.112"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.2281134128570557}},"branch_attrs":{"mutations":{"nuc":["G25647T","-28271A"],"ORF3a":["L85F"]},"labels":{"aa":"ORF3a: L85F"}}},{"name":"AY.111","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.111"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.111"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.194126844406128}},"branch_attrs":{"mutations":{"nuc":["C4456T"]}}},{"name":"AY.117","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.117"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.117"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.009012460708618}},"branch_attrs":{"mutations":{"nuc":["A1G","G2202T","G14186T","C15810T","C28708T"],"nsp12":["R249M"],"nsp2":["W466L"]},"labels":{"aa":"nsp12: R249M; nsp2: W466L"}}},{"name":"AY.118","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.118"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.118"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.8720552921295166}},"branch_attrs":{"mutations":{"nuc":["A1C","T826C","A27338T"],"ORF6":["E46V"]},"labels":{"aa":"ORF6: E46V"}}},{"name":"AY.126","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.126"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.126"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6271045207977295}},"branch_attrs":{"mutations":{"nuc":["A1T","C14925T","A21137G","A24110C","A25439C"],"ORF3a":["K16T"],"S":["I850L"],"nsp16":["K160R"]},"labels":{"aa":"ORF3a: K16T; S: I850L; nsp16: K160R","spike_mutations":"I850L"}}},{"name":"AY.128","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.128"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.128"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.377318859100342}},"branch_attrs":{"mutations":{"nuc":["C2973T","G15906T","G16795T","T28150C"],"ORF8":["F86S"],"nsp12":["Q822H"],"nsp13":["V187L"],"nsp3":["A85V"]},"labels":{"aa":"ORF8: F86S; nsp12: Q822H; nsp13: V187L; nsp3: A85V"}}},{"name":"AY.129","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.129"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.129"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.10140061378479}},"branch_attrs":{"mutations":{"nuc":["A21194G","G28001T","T28156C"],"ORF8":["I88T"],"nsp16":["D179G"]},"labels":{"aa":"ORF8: I88T; nsp16: D179G"}}},{"name":"AY.132","node_attrs":{"div":48,"Nextclade_pango":{"value":"AY.132"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.132"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.301616191864014}},"branch_attrs":{"mutations":{"nuc":["G1418A","A2172G","C4754T","C7945T","G11161A","T11488C","G18213A","T19500C","A19908G","C23683T","C25710T","G25855T","C27131T","G27870T","C27881A"],"ORF3a":["D155Y"],"ORF7b":["E39*","H42Q"],"nsp14":["M58I"],"nsp15":["I96M"],"nsp2":["A205T","K456R"],"nsp3":["P679S"]},"labels":{"aa":"ORF3a: D155Y; ORF7b: E39*, H42Q; nsp14: M58I; nsp15: I96M; nsp2: A205T, K456R; nsp3: P679S"}}},{"name":"AY.131","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.131"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.131"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.789443492889404}},"branch_attrs":{"mutations":{"nuc":["C14407T","G19999T","G22899T","A23064C","T29014C","G29688T"],"S":["G446V","N501T"],"nsp12":["L323F"],"nsp15":["V127F"]},"labels":{"aa":"S: G446V, N501T; nsp12: L323F; nsp15: V127F","spike_mutations":"G446V, N501T"}}},{"name":"AY.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.4940871000289917}},"branch_attrs":{"mutations":{"nuc":["C7851T"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}}},{"name":"AY.4.10","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.4.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.10"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9287588596343994}},"branch_attrs":{"mutations":{"nuc":["C4320T","C5512T","C7851T","T8604C","C10714T","C12513T","A16602G","G20663A","C23996T","G25757T","T27900C"],"ORF3a":["R122I"],"ORF8":["F3L"],"S":["P812S"],"nsp16":["S2N"],"nsp3":["A534V","A1711V"],"nsp4":["F17S"],"nsp8":["T141M"]},"labels":{"aa":"ORF3a: R122I; ORF8: F3L; S: P812S; nsp16: S2N; nsp3: A534V, A1711V; nsp4: F17S; nsp8: T141M","spike_mutations":"P812S"}}},{"name":"AY.4.3","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.506161689758301}},"branch_attrs":{"mutations":{"nuc":["C7851T","C21638T"],"S":["P26S"],"nsp3":["A1711V"]},"labels":{"aa":"S: P26S; nsp3: A1711V","spike_mutations":"P26S"}}},{"name":"AY.4.4","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6225411891937256}},"branch_attrs":{"mutations":{"nuc":["C7851T","G14209T","C21575T","C22000T","G24348C"],"S":["L5F","S929T"],"nsp12":["V257F"],"nsp3":["A1711V"]},"labels":{"aa":"S: L5F, S929T; nsp12: V257F; nsp3: A1711V","spike_mutations":"L5F, S929T"}}},{"name":"AY.4.5","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9815378189086914}},"branch_attrs":{"mutations":{"nuc":["C7851T","A14882C","G25337T"],"S":["D1259Y"],"nsp12":["D481A"],"nsp3":["A1711V"]},"labels":{"aa":"S: D1259Y; nsp12: D481A; nsp3: A1711V","spike_mutations":"D1259Y"}}},{"name":"AY.4.8","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.8"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.532318115234375}},"branch_attrs":{"mutations":{"nuc":["C2706T","C7851T","C11450A","A12124G","G25489T","C29774T"],"ORF3a":["A33S"],"nsp2":["T634I"],"nsp3":["A1711V"],"nsp6":["Q160K"]},"labels":{"aa":"ORF3a: A33S; nsp2: T634I; nsp3: A1711V; nsp6: Q160K"}}},{"name":"AY.4.7","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.366204261779785}},"branch_attrs":{"mutations":{"nuc":["A1T","C7851T","G14829T","G17193T","G26416T","C28291T"],"E":["V58F"],"ORF9b":["P3L"],"nsp12":["M463I"],"nsp13":["E319D"],"nsp3":["A1711V"]},"labels":{"aa":"E: V58F; ORF9b: P3L; nsp12: M463I; nsp13: E319D; nsp3: A1711V"}}},{"name":"AY.44","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.44"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.44"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.8040610551834106}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14014G","T21846C","A29700G"],"S":["I95T"],"nsp12":["F192V"]},"labels":{"aa":"S: I95T; nsp12: F192V","spike_mutations":"I95T"}}},{"name":"AY.6","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7358286380767822}},"branch_attrs":{"mutations":{"nuc":["G2336A","G17331T","T21846C"],"S":["I95T"],"nsp13":["E365D"],"nsp2":["D511N"]},"labels":{"aa":"S: I95T; nsp13: E365D; nsp2: D511N","spike_mutations":"I95T"}}},{"name":"AY.76","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.76"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.76"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.444540977478027}},"branch_attrs":{"mutations":{"nuc":["T7233C","A16775G","T21846C"],"S":["I95T"],"nsp13":["Y180C"],"nsp3":["L1505S"]},"labels":{"aa":"S: I95T; nsp13: Y180C; nsp3: L1505S","spike_mutations":"I95T"}}},{"name":"AY.77","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.77"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:120-122"},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.77"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.144852638244629}},"branch_attrs":{"mutations":{"nuc":["C10376T","T21846C","T27346C","-28250T","-28251T","-28252T","-28253C"],"ORF6":["Y49H"],"S":["I95T"],"nsp5":["P108S"]},"labels":{"aa":"ORF6: Y49H; S: I95T; nsp5: P108S","spike_mutations":"I95T"}}},{"name":"AY.80","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.80"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.80"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.398502349853516}},"branch_attrs":{"mutations":{"nuc":["G5017A","G12479A","C19186T","G19735T","T21846C","G28028T"],"ORF8":["W45C"],"S":["I95T"],"nsp15":["D39Y"],"nsp8":["V130I"]},"labels":{"aa":"ORF8: W45C; S: I95T; nsp15: D39Y; nsp8: V130I","spike_mutations":"I95T"}}},{"name":"AY.81","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.81"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.81"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.495382308959961}},"branch_attrs":{"mutations":{"nuc":["G11358A","T21846C","C23643T","G25340T","A28032G","C28087T","C29530T"],"ORF8":["I47V","A65V"],"S":["I95T","A694V","D1260Y"],"nsp6":["R129K"]},"labels":{"aa":"ORF8: I47V, A65V; S: I95T, A694V, D1260Y; nsp6: R129K","spike_mutations":"I95T, A694V, D1260Y"}}},{"name":"AY.79","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.79"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.79"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.318887233734131}},"branch_attrs":{"mutations":{"nuc":["T2125C","T21846C"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}}},{"name":"AY.82","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.82"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.82"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3766937255859375}},"branch_attrs":{"mutations":{"nuc":["C9144T","T21846C","C22783T"],"S":["I95T"],"nsp4":["S197F"]},"labels":{"aa":"S: I95T; nsp4: S197F","spike_mutations":"I95T"}}},{"name":"AY.84","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.84"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.84"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8311426639556885}},"branch_attrs":{"mutations":{"nuc":["T21846C","C27297T","G28086T"],"ORF8":["A65S"],"S":["I95T"]},"labels":{"aa":"ORF8: A65S; S: I95T","spike_mutations":"I95T"}}},{"name":"AY.83","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.83"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.83"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.158646106719971}},"branch_attrs":{"mutations":{"nuc":["C5544T","G15243T","T21846C","A25491T"],"S":["I95T"],"nsp12":["M601I"],"nsp3":["T942I"]},"labels":{"aa":"S: I95T; nsp12: M601I; nsp3: T942I","spike_mutations":"I95T"}}},{"name":"AY.87","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.87"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.87"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.119286060333252}},"branch_attrs":{"mutations":{"nuc":["C832T","C2091T","C12651T","C17156T","A19815T","T21846C","G27556T"],"ORF7a":["A55S"],"S":["I95T"],"nsp13":["T307I"],"nsp2":["T429I"],"nsp8":["T187I"]},"labels":{"aa":"ORF7a: A55S; S: I95T; nsp13: T307I; nsp2: T429I; nsp8: T187I","spike_mutations":"I95T"}}},{"name":"AY.86","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.86"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.86"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.11639928817749}},"branch_attrs":{"mutations":{"nuc":["G15380T","T21846C","G24095T","C29445T"],"N":["T391I"],"S":["I95T","A845S"],"nsp12":["S647I"]},"labels":{"aa":"N: T391I; S: I95T, A845S; nsp12: S647I","spike_mutations":"I95T, A845S"}}},{"name":"AY.88","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.88"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.88"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.1931376457214355}},"branch_attrs":{"mutations":{"nuc":["G20709T","T21846C","C28724T"],"N":["P151S"],"S":["I95T"],"nsp16":["M17I"]},"labels":{"aa":"N: P151S; S: I95T; nsp16: M17I","spike_mutations":"I95T"}}},{"name":"AY.90","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.90"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.90"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9920814037323}},"branch_attrs":{"mutations":{"nuc":["G9251A","G11083T","T21846C","C25931T","G26720A","G27990T","T28735C"],"ORF3a":["S180F"],"ORF8":["V33F"],"S":["I95T"],"nsp4":["V233I"],"nsp6":["L37F"]},"labels":{"aa":"ORF3a: S180F; ORF8: V33F; S: I95T; nsp4: V233I; nsp6: L37F","spike_mutations":"I95T"}}},{"name":"AY.94","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.94"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.94"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.735548973083496}},"branch_attrs":{"mutations":{"nuc":["G463A","G6367T","C15924T","G16975T","T21846C","C22987T"],"S":["I95T"],"nsp13":["V247F"],"nsp3":["Q1216H"]},"labels":{"aa":"S: I95T; nsp13: V247F; nsp3: Q1216H","spike_mutations":"I95T"}}},{"name":"AY.92","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.92"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.92"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.508190155029297}},"branch_attrs":{"mutations":{"nuc":["C28657T","C29167T"]}}},{"name":"AY.93","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.93"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.93"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6097846031188965}},"branch_attrs":{"mutations":{"nuc":["A1087G","C1101T","C7262T","T21846C"],"S":["I95T"],"nsp2":["S99F"],"nsp3":["L1515F"]},"labels":{"aa":"S: I95T; nsp2: S99F; nsp3: L1515F","spike_mutations":"I95T"}}},{"name":"NODE_0000544","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.529526472091675}},"branch_attrs":{"mutations":{"nuc":["C9559T","C15240T","T28007C"]}},"children":[{"name":"AY.101","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.101"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.101"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4137604236602783}},"branch_attrs":{"mutations":{"nuc":["C925T","C9474T","C25460T"],"ORF3a":["A23V"],"nsp4":["A307V"]},"labels":{"aa":"ORF3a: A23V; nsp4: A307V"}}},{"name":"AY.100","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.100"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.100"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2730963230133057}},"branch_attrs":{"mutations":{"nuc":["G17122T"],"nsp13":["A296S"]},"labels":{"aa":"nsp13: A296S"}}}]},{"name":"NODE_0000545","node_attrs":{"div":35,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.117180824279785}},"branch_attrs":{"mutations":{"nuc":["A17236G","T21846C"],"S":["I95T"],"nsp13":["I334V"]},"labels":{"aa":"S: I95T; nsp13: I334V","spike_mutations":"I95T"}},"children":[{"name":"AY.103","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.103"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.103"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.7256762981414795}},"branch_attrs":{"mutations":{"nuc":["C24208T"]}}},{"name":"AY.41","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.41"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.41"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3733155727386475}},"branch_attrs":{"mutations":{"nuc":["G1820A","G2272T","G7936T","G9220A","A13712G","C14119T","C18395T","G22346T","G22992T","G25062T","-28271A"],"S":["A262S","S477I","G1167V"],"nsp12":["K91R","P227S"],"nsp14":["A119V"],"nsp2":["G339S","K489N"]},"labels":{"aa":"S: A262S, S477I, G1167V; nsp12: K91R, P227S; nsp14: A119V; nsp2: G339S, K489N","spike_mutations":"A262S, S477I, G1167V"}}}]},{"name":"NODE_0000546","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.208604335784912}},"branch_attrs":{"mutations":{"nuc":["G16914T"]}},"children":[{"name":"AY.114","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.114"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.114"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.435467481613159}},"branch_attrs":{"mutations":{"nuc":["C884T","G19677T"],"nsp15":["Q19H"],"nsp2":["R27C"]},"labels":{"aa":"nsp15: Q19H; nsp2: R27C"}}},{"name":"AY.85","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.85"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.85"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.350363254547119}},"branch_attrs":{"mutations":{"nuc":["A708G","C1825T","T17748A","C25810T","G26428T","C26873T"],"E":["V62F"],"ORF3a":["L140F"],"nsp1":["E148G"]},"labels":{"aa":"E: V62F; ORF3a: L140F; nsp1: E148G"}}}]},{"name":"NODE_0000547","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.116"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.899040699005127}},"branch_attrs":{"mutations":{"nuc":["A10691G"],"nsp5":["I213V"]},"labels":{"aa":"nsp5: I213V"}},"children":[{"name":"AY.116","node_attrs":{"div":34,"Nextclade_pango":{"value":"AY.116"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.899040699005127}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.116.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.116.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.116.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.500979423522949}},"branch_attrs":{"mutations":{"nuc":["G12071A","C19160T","G20968A"],"nsp14":["S374F"],"nsp16":["V104I"],"nsp7":["D77N"]},"labels":{"aa":"nsp14: S374F; nsp16: V104I; nsp7: D77N"}}}]},{"name":"NODE_0000548","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.121"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.015531301498413}},"branch_attrs":{"mutations":{"nuc":["A1C","C13168T","C23557T","G25996T"],"ORF3a":["V202L"]},"labels":{"aa":"ORF3a: V202L"}},"children":[{"name":"AY.121.1","node_attrs":{"div":46,"Nextclade_pango":{"value":"AY.121.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4786579608917236}},"branch_attrs":{"mutations":{"nuc":["T209C","T6949C","C16726T","C19859T","C21648T","C27638T","C27737T","G28396A","G29690T"],"ORF7a":["A82V","T115I"],"ORF9b":["G38D"],"S":["T29I"],"nsp13":["H164Y"],"nsp15":["A80V"]},"labels":{"aa":"ORF7a: A82V, T115I; ORF9b: G38D; S: T29I; nsp13: H164Y; nsp15: A80V","spike_mutations":"T29I"}}},{"name":"AY.121","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.121"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.121"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.015531301498413}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000549","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.123"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.456477165222168}},"branch_attrs":{"mutations":{"nuc":["C897T","C5730T","A7519C","C15738T","G17790T","T21846C","C25350T","G27762T"],"ORF7b":["E3*"],"S":["I95T","P1263L"],"nsp13":["Q518H"],"nsp2":["A31V"],"nsp3":["T1004I"]},"labels":{"aa":"ORF7b: E3*; S: I95T, P1263L; nsp13: Q518H; nsp2: A31V; nsp3: T1004I","spike_mutations":"I95T, P1263L"}},"children":[{"name":"AY.123","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.123"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.456477165222168}},"branch_attrs":{"mutations":{}}},{"name":"AY.123.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.123.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.123.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.658041954040527}},"branch_attrs":{"mutations":{"nuc":["G20002T","A24410G"],"S":["N950D"],"nsp15":["D128Y"]},"labels":{"aa":"S: N950D; nsp15: D128Y","spike_mutations":"N950D"}}}]},{"name":"NODE_0000550","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.127"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1094322204589844}},"branch_attrs":{"mutations":{"nuc":["A1T","G25538T","C26054A"],"ORF3a":["G49V","T221K"]},"labels":{"aa":"ORF3a: G49V, T221K"}},"children":[{"name":"AY.127","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.127"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1094322204589844}},"branch_attrs":{"mutations":{}}},{"name":"AY.127.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.127.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.127.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6556131839752197}},"branch_attrs":{"mutations":{"nuc":["G242A","T7816C","A19445G","G23608T","C24138A","G28378T"],"ORF9b":["R32L"],"S":["T859N"],"nsp14":["K469R"]},"labels":{"aa":"ORF9b: R32L; S: T859N; nsp14: K469R","spike_mutations":"T859N"}}}]},{"name":"NODE_0000551","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.23"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3406074047088623}},"branch_attrs":{"mutations":{"nuc":["C1404T","C4752T","T21846C","G25352T"],"S":["I95T","V1264L"],"nsp2":["P200L"],"nsp3":["T678I"]},"labels":{"aa":"S: I95T, V1264L; nsp2: P200L; nsp3: T678I","spike_mutations":"I95T, V1264L"}},"children":[{"name":"AY.23","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3406074047088623}},"branch_attrs":{"mutations":{}}},{"name":"AY.23.1","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.23.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4683518409729004}},"branch_attrs":{"mutations":{"nuc":["C1263T","C5497T","A7537G","C12100T","A14748G","G17679T","T22213C","C25262A"],"S":["L1234I"],"nsp2":["T153M"]},"labels":{"aa":"S: L1234I; nsp2: T153M","spike_mutations":"L1234I"}}}]},{"name":"NODE_0000552","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.29"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5792689323425293}},"branch_attrs":{"mutations":{"nuc":["A1G","C5239T","T5514C"],"nsp3":["V932A"]},"labels":{"aa":"nsp3: V932A"}},"children":[{"name":"AY.29","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5792689323425293}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.29.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.29.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.29.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.489469528198242}},"branch_attrs":{"mutations":{"nuc":["G22081T"],"S":["Q173H"]},"labels":{"aa":"S: Q173H","spike_mutations":"Q173H"}}}]},{"name":"NODE_0000553","node_attrs":{"div":36,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.512903690338135}},"branch_attrs":{"mutations":{"nuc":["T21846C","C23277T","G24124A","-28271A"],"S":["I95T","T572I"]},"labels":{"aa":"S: I95T, T572I","spike_mutations":"I95T, T572I"}},"children":[{"name":"AY.32","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.32"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.96708345413208}},"branch_attrs":{"mutations":{"nuc":["C9286T","C21304T"],"nsp16":["R216C"]},"labels":{"aa":"nsp16: R216C"}}},{"name":"AY.95","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.95"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.95"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.070797920227051}},"branch_attrs":{"mutations":{"nuc":["T22293C"],"S":["L244S"]},"labels":{"aa":"S: L244S","spike_mutations":"L244S"}}}]},{"name":"NODE_0000554","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.33"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1432621479034424}},"branch_attrs":{"mutations":{"nuc":["A21647G","T21846C","C22311T"],"S":["T29A","I95T","T250I"]},"labels":{"aa":"S: T29A, I95T, T250I","spike_mutations":"T29A, I95T, T250I"}},"children":[{"name":"AY.33","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.33"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1432621479034424}},"branch_attrs":{"mutations":{}}},{"name":"AY.33.1","node_attrs":{"div":47,"Nextclade_pango":{"value":"AY.33.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":37},"totalAminoacidDeletions":{"value":26},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:77-122"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.33.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C4182T","T10190C","A11111G","C14318T","C17439T","A18887G","G21010T","C21707T","C22458T","G23401T","G23522A","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-"],"S":["H49Y","T299I","Q613H","E654K"],"nsp12":["T293I"],"nsp14":["H283R"],"nsp16":["V118L"],"nsp3":["S488F"],"nsp5":["S46P"],"nsp6":["M47V"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-; S: H49Y, T299I, Q613H, E654K; nsp12: T293I; nsp14: H283R; nsp16: V118L; nsp3: S488F; nsp5: S46P; nsp6: M47V","spike_mutations":"H49Y, T299I, Q613H, E654K"}}}]},{"name":"NODE_0000555","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.42"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0401339530944824}},"branch_attrs":{"mutations":{"nuc":["G2258A","C12073T","C15237T","C25872T"],"nsp2":["V485I"]},"labels":{"aa":"nsp2: V485I"}},"children":[{"name":"AY.42","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.42"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0401339530944824}},"branch_attrs":{"mutations":{}}},{"name":"AY.42.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.42.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.734266996383667}},"branch_attrs":{"mutations":{"nuc":["T4081A","C23718T","C24374T"],"S":["T719I","L938F"],"nsp3":["S454R"]},"labels":{"aa":"S: T719I, L938F; nsp3: S454R","spike_mutations":"T719I, L938F"}}}]},{"name":"NODE_0000556","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.98"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.87161922454834}},"branch_attrs":{"mutations":{"nuc":["G526T","C19524T","T21846C"],"S":["I95T"],"nsp1":["E87D"]},"labels":{"aa":"S: I95T; nsp1: E87D","spike_mutations":"I95T"}},"children":[{"name":"AY.98","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.98"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.87161922454834}},"branch_attrs":{"mutations":{}}},{"name":"AY.98.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.98.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.98.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.623765707015991}},"branch_attrs":{"mutations":{"nuc":["G2518T","G5437T","C7768T","C22314T","G28086T"],"ORF8":["A65S"],"S":["P251L"],"nsp3":["E906D"]},"labels":{"aa":"ORF8: A65S; S: P251L; nsp3: E906D","spike_mutations":"P251L"}}}]},{"name":"NODE_0000557","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.102"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.505928039550781}},"branch_attrs":{"mutations":{"nuc":["G1495T","G11083T","A27690T","C29836T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"AY.102","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.102"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.505928039550781}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000558","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.102"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.112253189086914}},"branch_attrs":{"mutations":{"nuc":["A21987G","T25333C","A29700G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.102.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.102.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-5.035328388214111}},"branch_attrs":{"mutations":{"nuc":["G25218T"],"S":["G1219V"]},"labels":{"aa":"S: G1219V","spike_mutations":"G1219V"}}},{"name":"AY.102.2","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.102.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.102.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.796263694763184}},"branch_attrs":{"mutations":{"nuc":["C26395A","G29861T","G29862A","T29867-"],"E":["L51I"]},"labels":{"aa":"E: L51I"}}}]}]},{"name":"NODE_0000559","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8980414867401123}},"branch_attrs":{"mutations":{"nuc":["C745T"]}},"children":[{"name":"AY.104","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.104"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.104"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.190604209899902}},"branch_attrs":{"mutations":{"nuc":["T13048C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"AY.108","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.108"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.108"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.212310314178467}},"branch_attrs":{"mutations":{"nuc":["T2C","G370T","C823T","C6828T"],"nsp3":["S1370F"]},"labels":{"aa":"nsp3: S1370F"}}},{"name":"AY.125","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.125"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.125"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7532522678375244}},"branch_attrs":{"mutations":{"nuc":["C6730T","C13944T","G15906T","G18905A","G25471T","A26786G"],"ORF3a":["D27Y"],"nsp12":["Q822H"],"nsp14":["R289H"]},"labels":{"aa":"ORF3a: D27Y; nsp12: Q822H; nsp14: R289H"}}}]},{"name":"NODE_0000560","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5868980884552}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"AY.113","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.113"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.113"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0679993629455566}},"branch_attrs":{"mutations":{"nuc":["A1G","C9165T","A12772G","C15240T"],"nsp4":["T204I"]},"labels":{"aa":"nsp4: T204I"}}},{"name":"NODE_0000561","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.124"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5670838356018066}},"branch_attrs":{"mutations":{"nuc":["C1593T","C21301A"],"nsp16":["P215T"],"nsp2":["S263F"]},"labels":{"aa":"nsp16: P215T; nsp2: S263F"}},"children":[{"name":"AY.124","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.124"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.5670838356018066}},"branch_attrs":{"mutations":{}}},{"name":"AY.124.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.124.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":35},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.124.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.139280796051025}},"branch_attrs":{"mutations":{"nuc":["C4276T","G25445T","G25720T","C26058T","G28628T"],"N":["A119S"],"ORF3a":["G18V","A110S"]},"labels":{"aa":"N: A119S; ORF3a: G18V, A110S"}}}]}]},{"name":"NODE_0000562","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.119"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9526422023773193}},"branch_attrs":{"mutations":{"nuc":["C8829T","G19006T"],"nsp14":["A323S"],"nsp4":["A92V"]},"labels":{"aa":"nsp14: A323S; nsp4: A92V"}},"children":[{"name":"AY.119","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.119"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9526422023773193}},"branch_attrs":{"mutations":{}}},{"name":"AY.119.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.119.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":38},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.377318382263184}},"branch_attrs":{"mutations":{"nuc":["C100T","C2973T","G17338T","C22227T","T24063C","G25552T","G26031T","T26621C","G29392T"],"N":["K373N"],"ORF3a":["A54S","Q213H"],"S":["A222V","I834T"],"nsp13":["A368S"],"nsp3":["A85V"]},"labels":{"aa":"N: K373N; ORF3a: A54S, Q213H; S: A222V, I834T; nsp13: A368S; nsp3: A85V","spike_mutations":"A222V, I834T"}}},{"name":"AY.119.2","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.119.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.119.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.131967067718506}},"branch_attrs":{"mutations":{"nuc":["G23587C"],"S":["Q675H"]},"labels":{"aa":"S: Q675H","spike_mutations":"Q675H"}}}]},{"name":"NODE_0000563","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.25"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.314873695373535}},"branch_attrs":{"mutations":{"nuc":["A1G","T21846C","G26107C","A27507C"],"ORF3a":["E239Q"],"S":["I95T"]},"labels":{"aa":"ORF3a: E239Q; S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.25","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.25"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.314873695373535}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000564","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.25.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.4324440956115723}},"branch_attrs":{"mutations":{"nuc":["A3948G","G11562T"],"nsp3":["D410G"],"nsp6":["C197F"]},"labels":{"aa":"nsp3: D410G; nsp6: C197F"}},"children":[{"name":"AY.25.1.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.25.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.2396397590637207}},"branch_attrs":{"mutations":{"nuc":["G2564A","A21987G","G23948T"],"S":["D142G","D796Y"],"nsp2":["E587K"]},"labels":{"aa":"S: D142G, D796Y; nsp2: E587K","spike_mutations":"D142G, D796Y"}}},{"name":"AY.25.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.25.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.4324440956115723}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000565","node_attrs":{"div":35,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.468881368637085}},"branch_attrs":{"mutations":{"nuc":["T21846C","C25413T","-28271A"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.45","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.45"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.45"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.299954891204834}},"branch_attrs":{"mutations":{"nuc":["G13812T"],"nsp12":["M124I"]},"labels":{"aa":"nsp12: M124I"}}},{"name":"NODE_0000566","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.91"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.198517322540283}},"branch_attrs":{"mutations":{"nuc":["T1871C","C28236T","G29744A"],"ORF8":["R115C"],"nsp2":["F356L"]},"labels":{"aa":"ORF8: R115C; nsp2: F356L"}},"children":[{"name":"AY.91","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.91"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.198517322540283}},"branch_attrs":{"mutations":{}}},{"name":"AY.91.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.91.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.91.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.921102523803711}},"branch_attrs":{"mutations":{"nuc":["C15540T","C17010T","G25650T","A28271-","C28310T"],"N":["P13S"],"ORF3a":["L86F"]},"labels":{"aa":"N: P13S; ORF3a: L86F"}}}]}]},{"name":"NODE_0000567","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.7"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8977537155151367}},"branch_attrs":{"mutations":{"nuc":["T2C","G2944A","G11365T","G12718T","T21846C","G27566T","C27629A"],"ORF7a":["C58F","A79D"],"S":["I95T"],"nsp9":["Q11H"]},"labels":{"aa":"ORF7a: C58F, A79D; S: I95T; nsp9: Q11H","spike_mutations":"I95T"}},"children":[{"name":"AY.7.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1598989963531494}},"branch_attrs":{"mutations":{"nuc":["T15882G","A18675G"]}}},{"name":"AY.7","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8977537155151367}},"branch_attrs":{"mutations":{}}},{"name":"AY.7.2","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.7.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.7634453773498535}},"branch_attrs":{"mutations":{"nuc":["C2T","G25445T"],"ORF3a":["G18V"]},"labels":{"aa":"ORF3a: G18V"}}}]},{"name":"NODE_0000568","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.99"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.52271842956543}},"branch_attrs":{"mutations":{"nuc":["A3536G","T13216C","C15240T","T21846C"],"S":["I95T"],"nsp3":["I273V"]},"labels":{"aa":"S: I95T; nsp3: I273V","spike_mutations":"I95T"}},"children":[{"name":"AY.99","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.99"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.52271842956543}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"NODE_0000569","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.99"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.392517566680908}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.99.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.99.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.140461444854736}},"branch_attrs":{"mutations":{"nuc":["C8994T"],"nsp4":["T147I"]},"labels":{"aa":"nsp4: T147I"}}},{"name":"AY.99.2","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.99.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.99.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7914319038391113}},"branch_attrs":{"mutations":{"nuc":["C4927T","A5638G","C12525T"],"nsp8":["T145I"]},"labels":{"aa":"nsp8: T145I"}}}]}]},{"name":"NODE_0000570","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.120"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.007944345474243}},"branch_attrs":{"mutations":{"nuc":["C6408T","A25003G"],"nsp3":["S1230F"]},"labels":{"aa":"nsp3: S1230F"}},"children":[{"name":"AY.120","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.120"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.007944345474243}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.120.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.541743040084839}},"branch_attrs":{"mutations":{"nuc":["C11095T"]}}},{"name":"NODE_0000571","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.120.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.589193820953369}},"branch_attrs":{"mutations":{"nuc":["G174T","C21758T"],"S":["H66Y"]},"labels":{"aa":"S: H66Y","spike_mutations":"H66Y"}},"children":[{"name":"AY.120.2","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.120.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.589193820953369}},"branch_attrs":{"mutations":{}}},{"name":"AY.120.2.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.120.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.120.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.859754800796509}},"branch_attrs":{"mutations":{"nuc":["C7105T","C13138T","T27017A"]}}}]}]},{"name":"NODE_0000572","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.122"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.137082099914551}},"branch_attrs":{"mutations":{"nuc":["G1048T","T21846C"],"S":["I95T"],"nsp2":["K81N"]},"labels":{"aa":"S: I95T; nsp2: K81N","spike_mutations":"I95T"}},"children":[{"name":"AY.122.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.122.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.737865447998047}},"branch_attrs":{"mutations":{"nuc":["G13892A","G14772A","G22793T"],"S":["A411S"],"nsp12":["C151Y"]},"labels":{"aa":"S: A411S; nsp12: C151Y","spike_mutations":"A411S"}}},{"name":"AY.122","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.122"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.137082099914551}},"branch_attrs":{"mutations":{}}},{"name":"AY.122.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.122.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.565906286239624}},"branch_attrs":{"mutations":{"nuc":["C19983T","G20937T","C23934T","C25516T"],"ORF3a":["P42S"],"S":["T791I"]},"labels":{"aa":"ORF3a: P42S; S: T791I","spike_mutations":"T791I"}}},{"name":"AY.122.3","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.122.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.122.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.337819576263428}},"branch_attrs":{"mutations":{"nuc":["T168C","C12513T","G17338A","T17694C","T20838C","G23401T","C27527T","C28873A"],"ORF7a":["P45L"],"S":["Q613H"],"nsp13":["A368T"],"nsp8":["T141M"]},"labels":{"aa":"ORF7a: P45L; S: Q613H; nsp13: A368T; nsp8: T141M","spike_mutations":"Q613H"}}}]},{"name":"NODE_0000573","node_attrs":{"div":34,"Nextclade_pango":{"value":"B.1.617.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3768041133880615}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"AY.22","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.22"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.22"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3188090324401855}},"branch_attrs":{"mutations":{"nuc":["G11083T","T12496C","G14209T","A21987G","G22216T","G26062T"],"ORF3a":["G224C"],"S":["D142G","Q218H"],"nsp12":["V257F"],"nsp6":["L37F"]},"labels":{"aa":"ORF3a: G224C; S: D142G, Q218H; nsp12: V257F; nsp6: L37F","spike_mutations":"D142G, Q218H"}}},{"name":"AY.36","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.36"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9737911224365234}},"branch_attrs":{"mutations":{"nuc":["T15628C","G18079T","A20532G","C29738T"],"nsp12":["C730R"],"nsp14":["V14L"]},"labels":{"aa":"nsp12: C730R; nsp14: V14L"}}},{"name":"NODE_0000574","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.20"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.005821704864502}},"branch_attrs":{"mutations":{"nuc":["C2061T"],"nsp2":["A419V"]},"labels":{"aa":"nsp2: A419V"}},"children":[{"name":"AY.20","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.20"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.005821704864502}},"branch_attrs":{"mutations":{}}},{"name":"AY.20.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.20.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.686790943145752}},"branch_attrs":{"mutations":{"nuc":["C8880T","G9190T","C11173T","C24106T","G25481T","C27393T","G29737T"],"ORF3a":["R30L"],"nsp4":["T109M"]},"labels":{"aa":"ORF3a: R30L; nsp4: T109M"}}}]}]},{"name":"NODE_0000575","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.3"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6765198707580566}},"branch_attrs":{"mutations":{"nuc":["T3C","A11456G","T21846C","G29050A","C29509T"],"S":["I95T"],"nsp6":["I162V"]},"labels":{"aa":"S: I95T; nsp6: I162V","spike_mutations":"I95T"}},"children":[{"name":"AY.3","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.6765198707580566}},"branch_attrs":{"mutations":{}}},{"name":"AY.3.2","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8443009853363037}},"branch_attrs":{"mutations":{"nuc":["G5155A","C5784T","A10075G","A21987G","C22338T","C29546T","C29750T"],"S":["D142G","T259I"],"nsp3":["T1022I"]},"labels":{"aa":"S: D142G, T259I; nsp3: T1022I","spike_mutations":"D142G, T259I"}}},{"name":"NODE_0000576","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.3"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2108216285705566}},"branch_attrs":{"mutations":{"nuc":["T23284C","C25339T"]}},"children":[{"name":"AY.3.1","node_attrs":{"div":44,"Nextclade_pango":{"value":"AY.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.9937119483947754}},"branch_attrs":{"mutations":{"nuc":["G3644T","C18115T","C20199T","A21987G"],"S":["D142G"],"nsp14":["H26Y"],"nsp3":["D309Y"]},"labels":{"aa":"S: D142G; nsp14: H26Y; nsp3: D309Y","spike_mutations":"D142G"}}},{"name":"AY.3.3","node_attrs":{"div":47,"Nextclade_pango":{"value":"AY.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.3.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.715099334716797}},"branch_attrs":{"mutations":{"nuc":["T2083C","A6229G","C9924T","T12538C","G21770A","A22803G","A26021C"],"ORF3a":["D210A"],"S":["V70I","Q414R"],"nsp4":["A457V"]},"labels":{"aa":"ORF3a: D210A; S: V70I, Q414R; nsp4: A457V","spike_mutations":"V70I, Q414R"}}}]}]},{"name":"NODE_0000577","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.34"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4385077953338623}},"branch_attrs":{"mutations":{"nuc":["A1G","G9441T","G18255T","C22498T","G23593C","G26109A","C26681T","G27014T"],"S":["Q677H"],"nsp14":["M72I"],"nsp4":["C296F"]},"labels":{"aa":"S: Q677H; nsp14: M72I; nsp4: C296F","spike_mutations":"Q677H"}},"children":[{"name":"AY.34","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.34"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4385077953338623}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.2","node_attrs":{"div":45,"Nextclade_pango":{"value":"AY.34.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":35},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.6427252292633057}},"branch_attrs":{"mutations":{"nuc":["G11417T","A14457G","C21110T","C24138T"],"S":["T859I"],"nsp16":["T151I"],"nsp6":["V149F"]},"labels":{"aa":"S: T859I; nsp16: T151I; nsp6: V149F","spike_mutations":"T859I"}}},{"name":"NODE_0000578","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.34.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.636735677719116}},"branch_attrs":{"mutations":{"nuc":["C25355T","C28961T"],"N":["L230F"],"S":["L1265F"]},"labels":{"aa":"N: L230F; S: L1265F","spike_mutations":"L1265F"}},"children":[{"name":"AY.34.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.34.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.636735677719116}},"branch_attrs":{"mutations":{}}},{"name":"AY.34.1.1","node_attrs":{"div":46,"Nextclade_pango":{"value":"AY.34.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.34.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8207154273986816}},"branch_attrs":{"mutations":{"nuc":["C2106T","G8017T","A21987G"],"S":["D142G"],"nsp2":["T434I"]},"labels":{"aa":"S: D142G; nsp2: T434I","spike_mutations":"D142G"}}}]}]},{"name":"NODE_0000579","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.39"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.785830497741699}},"branch_attrs":{"mutations":{"nuc":["G21372T","G27604A"],"ORF7a":["V71I"],"nsp16":["Q238H"]},"labels":{"aa":"ORF7a: V71I; nsp16: Q238H"}},"children":[{"name":"AY.39","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.785830497741699}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.2","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.39.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.734314203262329}},"branch_attrs":{"mutations":{"nuc":["G2494T","G5716T","C6883T","A21987G","G24781C"],"S":["D142G","K1073N"],"nsp2":["E563D"],"nsp3":["K999N"]},"labels":{"aa":"S: D142G, K1073N; nsp2: E563D; nsp3: K999N","spike_mutations":"D142G, K1073N"}}},{"name":"NODE_0000580","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.39.1"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0565383434295654}},"branch_attrs":{"mutations":{"nuc":["A13482G"]}},"children":[{"name":"AY.39.1.2","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.39.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:78-122"},"designation_date":{"value":"2021-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.295746326446533}},"branch_attrs":{"mutations":{"nuc":["G1577A","C18555T","C25568T","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF3a":["A59V"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"nsp2":["V258I"]},"labels":{"aa":"ORF3a: A59V; ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; nsp2: V258I"}}},{"name":"AY.39.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0565383434295654}},"branch_attrs":{"mutations":{}}},{"name":"AY.39.1.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.39.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3922364711761475}},"branch_attrs":{"mutations":{"nuc":["G19563T"],"nsp14":["L508F"]},"labels":{"aa":"nsp14: L508F"}}},{"name":"AY.39.1.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.39.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":11},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:78-122"},"designation_date":{"value":"2021-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.39.1.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9028074741363525}},"branch_attrs":{"mutations":{"nuc":["G2164T","A21987G","C25046G","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-"],"ORF7a":["I71-","K72-","H73-","V74-","Y75-","Q76-","L77-"],"S":["D142G","P1162A"],"nsp2":["E453D"]},"labels":{"aa":"ORF7a: I71-, K72-, H73-, V74-, Y75-, Q76-, L77-; S: D142G, P1162A; nsp2: E453D","spike_mutations":"D142G, P1162A"}}}]}]},{"name":"NODE_0000581","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.5"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3081870079040527}},"branch_attrs":{"mutations":{"nuc":["T21846C","G24928T"],"S":["I95T"]},"labels":{"aa":"S: I95T","spike_mutations":"I95T"}},"children":[{"name":"AY.5","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3081870079040527}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000582","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.5"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.431300640106201}},"branch_attrs":{"mutations":{"nuc":["C29253T"],"N":["S327L"]},"labels":{"aa":"N: S327L"}},"children":[{"name":"AY.5.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.416350364685059}},"branch_attrs":{"mutations":{"nuc":["C12369T","C25572T"],"nsp8":["T93I"]},"labels":{"aa":"nsp8: T93I"}}},{"name":"AY.5.3","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8519368171691895}},"branch_attrs":{"mutations":{"nuc":["C7488T"],"nsp3":["T1590I"]},"labels":{"aa":"nsp3: T1590I"}}},{"name":"AY.5.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.63433313369751}},"branch_attrs":{"mutations":{"nuc":["C27143A"],"M":["N207K"]},"labels":{"aa":"M: N207K"}}},{"name":"AY.5.4","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.515988826751709}},"branch_attrs":{"mutations":{"nuc":["C1191T"],"nsp2":["P129L"]},"labels":{"aa":"nsp2: P129L"}}},{"name":"AY.5.5","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.5.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C6840T","G17193T","T23398C"],"nsp13":["E319D"],"nsp3":["A1374V"]},"labels":{"aa":"nsp13: E319D; nsp3: A1374V"}}}]}]},{"name":"NODE_0000583","node_attrs":{"div":35,"Nextclade_pango":{"value":"AY.4"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-1.6842306852340698}},"branch_attrs":{"mutations":{"nuc":["C7851T","T17040C"],"nsp3":["A1711V"]},"labels":{"aa":"nsp3: A1711V"}},"children":[{"name":"AY.4.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.036841869354248}},"branch_attrs":{"mutations":{"nuc":["C2706T","T18927C","A20374C","G22899T"],"S":["G446V"],"nsp15":["I252L"],"nsp2":["T634I"]},"labels":{"aa":"S: G446V; nsp15: I252L; nsp2: T634I","spike_mutations":"G446V"}}},{"name":"AY.4.6","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.1065313816070557}},"branch_attrs":{"mutations":{"nuc":["C16293T","C19524T","C20404T","A28967G"],"N":["S232G"],"nsp15":["P262S"]},"labels":{"aa":"N: S232G; nsp15: P262S"}}},{"name":"AY.4.9","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.9"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8668172359466553}},"branch_attrs":{"mutations":{"nuc":["C3140T","T4066A","C12513T"],"nsp3":["P141S"],"nsp8":["T141M"]},"labels":{"aa":"nsp3: P141S; nsp8: T141M"}}},{"name":"NODE_0000584","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.2"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5732269287109375}},"branch_attrs":{"mutations":{"nuc":["T21995C","C22227T","C25614T"],"S":["Y145H","A222V"]},"labels":{"aa":"S: Y145H, A222V","spike_mutations":"Y145H, A222V"}},"children":[{"name":"AY.4.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.5732269287109375}},"branch_attrs":{"mutations":{}}},{"name":"AY.4.2.1","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.4.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.891268253326416}},"branch_attrs":{"mutations":{"nuc":["C15720T","C18687T","G21668T","G28878T"],"N":["S202I"],"S":["V36F"]},"labels":{"aa":"N: S202I; S: V36F","spike_mutations":"V36F"}}},{"name":"AY.4.2.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.4512696266174316}},"branch_attrs":{"mutations":{"nuc":["G26526T"],"M":["A2S"]},"labels":{"aa":"M: A2S"}}},{"name":"AY.4.2.2","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.4.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":33},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.4.2.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.7742323875427246}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}}]}]},{"name":"NODE_0000585","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.46"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.140479564666748}},"branch_attrs":{"mutations":{"nuc":["A1C","C10977T","T21846C"],"S":["I95T"],"nsp6":["A2V"]},"labels":{"aa":"S: I95T; nsp6: A2V","spike_mutations":"I95T"}},"children":[{"name":"AY.46.1","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.9886834621429443}},"branch_attrs":{"mutations":{"nuc":["T25673C"],"ORF3a":["L94P"]},"labels":{"aa":"ORF3a: L94P"}}},{"name":"AY.46.2","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8988404273986816}},"branch_attrs":{"mutations":{"nuc":["A17799G","-28271A"]}}},{"name":"AY.46","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.46"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.140479564666748}},"branch_attrs":{"mutations":{"nuc":["-28271A"]}}},{"name":"AY.46.3","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.46.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["G11083T","G14186T","C19637T","A21987G","G28378T"],"ORF9b":["R32L"],"S":["D142G"],"nsp12":["R249M"],"nsp15":["A6V"],"nsp6":["L37F"]},"labels":{"aa":"ORF9b: R32L; S: D142G; nsp12: R249M; nsp15: A6V; nsp6: L37F","spike_mutations":"D142G"}}},{"name":"AY.46.5","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.46.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.0682404041290283}},"branch_attrs":{"mutations":{"nuc":["C15569T","T16242G"],"nsp12":["T710I"]},"labels":{"aa":"nsp12: T710I"}}},{"name":"AY.46.4","node_attrs":{"div":37,"Nextclade_pango":{"value":"AY.46.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":30},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3499815464019775}},"branch_attrs":{"mutations":{"nuc":["G23545T"],"S":["E661D"]},"labels":{"aa":"S: E661D","spike_mutations":"E661D"}}},{"name":"AY.46.6","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.46.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.46.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.8154752254486084}},"branch_attrs":{"mutations":{"nuc":["C6310T","C8326T"]}}}]},{"name":"NODE_0000586","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.29671049118042}},"branch_attrs":{"mutations":{"nuc":["C15952A","T21846C","A28299T"],"N":["Q9L"],"ORF9b":["S6C"],"S":["I95T"],"nsp12":["L838I"]},"labels":{"aa":"N: Q9L; ORF9b: S6C; S: I95T; nsp12: L838I","spike_mutations":"I95T"}},"children":[{"name":"AY.43","node_attrs":{"div":36,"Nextclade_pango":{"value":"AY.43"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-10-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.29671049118042}},"branch_attrs":{"mutations":{}}},{"name":"AY.43.5","node_attrs":{"div":43,"Nextclade_pango":{"value":"AY.43.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.5"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.645293712615967}},"branch_attrs":{"mutations":{"nuc":["A17457G","A23064G","C23638T","C24937T","C28045T","G28857T","G29179T"],"N":["R195I"],"ORF8":["A51V"],"S":["N501S"]},"labels":{"aa":"N: R195I; ORF8: A51V; S: N501S","spike_mutations":"N501S"}}},{"name":"NODE_0000587","node_attrs":{"div":38,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.2766566276550293}},"branch_attrs":{"mutations":{"nuc":["C18744T","C24130T"]}},"children":[{"name":"AY.43.3","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.3"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.8277058601379395}},"branch_attrs":{"mutations":{"nuc":["C19955T"],"nsp15":["T112I"]},"labels":{"aa":"nsp15: T112I"}}},{"name":"AY.43.4","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.4"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.7761340141296387}},"branch_attrs":{"mutations":{"nuc":["C5241T"],"nsp3":["P841L"]},"labels":{"aa":"nsp3: P841L"}}},{"name":"AY.43.6","node_attrs":{"div":42,"Nextclade_pango":{"value":"AY.43.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":34},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.6"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-3.3442533016204834}},"branch_attrs":{"mutations":{"nuc":["C233T","C1952A","T27409C","G29081T"],"N":["V270L"],"ORF7a":["F6L"],"nsp2":["Q383K"]},"labels":{"aa":"N: V270L; ORF7a: F6L; nsp2: Q383K"}}},{"name":"NODE_0000588","node_attrs":{"div":39,"Nextclade_pango":{"value":"AY.43"},"clade_who":{"value":"Delta"},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-2.3868703842163086}},"branch_attrs":{"mutations":{"nuc":["A21987G"],"S":["D142G"]},"labels":{"aa":"S: D142G","spike_mutations":"D142G"}},"children":[{"name":"AY.43.2","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.43.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.2"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.030745029449463}},"branch_attrs":{"mutations":{"nuc":["G3728T"],"nsp3":["G337C"]},"labels":{"aa":"nsp3: G337C"}}},{"name":"AY.43.1","node_attrs":{"div":41,"Nextclade_pango":{"value":"AY.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":32},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.1"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.167747497558594}},"branch_attrs":{"mutations":{"nuc":["C12663T","C25433T"],"ORF3a":["T14I"],"nsp8":["A191V"]},"labels":{"aa":"ORF3a: T14I; nsp8: A191V"}}},{"name":"AY.43.7","node_attrs":{"div":40,"Nextclade_pango":{"value":"AY.43.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Delta"},"totalAminoacidSubstitutions":{"value":31},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21J (Delta)"},"partiallyAliased":{"value":"B.1.617.2.43.7"},"clade_nextstrain":{"value":"21J"},"clade_membership":{"value":"21J"},"placement_prior":{"value":-4.19292688369751}},"branch_attrs":{"mutations":{"nuc":["C24378T"],"S":["S939F"]},"labels":{"aa":"S: S939F","spike_mutations":"S939F"}}}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000589","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{"nuc":["G28881A","G28882A","G28883C"],"N":["R203K","G204R"]},"labels":{"aa":"N: R203K, G204R","clade":"20B"}},"children":[{"name":"B.1.1","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.111","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.111"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.111"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.088438510894775}},"branch_attrs":{"mutations":{"nuc":["T27447C","T29661C"],"ORF10":["F35S"]},"labels":{"aa":"ORF10: F35S"}}},{"name":"B.1.1.117","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.117"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.117"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.576686382293701}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}},{"name":"B.1.1.101","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.101"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.101"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.798060417175293}},"branch_attrs":{"mutations":{"nuc":["G8371T","G29868A"],"nsp3":["Q1884H"]},"labels":{"aa":"nsp3: Q1884H"}}},{"name":"B.1.1.115","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.115"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.115"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.550750732421875}},"branch_attrs":{"mutations":{"nuc":["G26918T","T29464C"]}}},{"name":"B.1.1.121","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.121"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.121"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.167267799377441}},"branch_attrs":{"mutations":{"nuc":["C27538T"]}}},{"name":"B.1.1.133","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.133"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.133"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4965T","A8072G","A16011G","A21213G"],"nsp3":["T749I","N1785D"]},"labels":{"aa":"nsp3: T749I, N1785D"}}},{"name":"B.1.1.141","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.141"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.141"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.266036510467529}},"branch_attrs":{"mutations":{"nuc":["T22020C","G26056T"],"ORF3a":["D222Y"],"S":["M153T"]},"labels":{"aa":"ORF3a: D222Y; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.135","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.135"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.135"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.479883193969727}},"branch_attrs":{"mutations":{"nuc":["C10376T"],"nsp5":["P108S"]},"labels":{"aa":"nsp5: P108S"}}},{"name":"B.1.1.161","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.161"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":3},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.161"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.094921588897705}},"branch_attrs":{"mutations":{"nuc":["G23403A"],"S":["G614D"]},"labels":{"aa":"S: G614D","spike_mutations":"G614D"}}},{"name":"B.1.1.163","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.163"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.163"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.996835231781006}},"branch_attrs":{"mutations":{"nuc":["G11029A","C21772T","C29518T"]}}},{"name":"B.1.1.157","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.157"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.157"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.1433210372924805}},"branch_attrs":{"mutations":{"nuc":["C6145T","G11272A","C17678T"],"nsp13":["T481M"],"nsp6":["M100I"]},"labels":{"aa":"nsp13: T481M; nsp6: M100I"}}},{"name":"B.1.1.176","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.176"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.176"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8188023567199707}},"branch_attrs":{"mutations":{"nuc":["C8208T","G9267A","T9667C","G25947T","G28361A"],"N":["G30R"],"ORF3a":["Q185H"],"ORF9b":["M26I"],"nsp3":["T1830I"],"nsp4":["S238N"]},"labels":{"aa":"N: G30R; ORF3a: Q185H; ORF9b: M26I; nsp3: T1830I; nsp4: S238N"}}},{"name":"B.1.1.171","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.171"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.171"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.768898010253906}},"branch_attrs":{"mutations":{"nuc":["C1437T","G29745T"],"nsp2":["S211F"]},"labels":{"aa":"nsp2: S211F"}}},{"name":"B.1.1.186","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.186"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.186"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.552818775177002}},"branch_attrs":{"mutations":{"nuc":["C4113T","G21974C","C23191T"],"S":["D138H"],"nsp3":["A465V"]},"labels":{"aa":"S: D138H; nsp3: A465V","spike_mutations":"D138H"}}},{"name":"B.1.1.174","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.174"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.174"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.572410583496094}},"branch_attrs":{"mutations":{"nuc":["G28378T"],"ORF9b":["R32L"]},"labels":{"aa":"ORF9b: R32L"}}},{"name":"B.1.1.189","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.189"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.189"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.426564693450928}},"branch_attrs":{"mutations":{"nuc":["C9430T","C12823T"]}}},{"name":"B.1.1.192","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.192"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.192"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.360202312469482}},"branch_attrs":{"mutations":{"nuc":["A1G","C673T"]}}},{"name":"B.1.1.203","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.203"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.203"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.988719463348389}},"branch_attrs":{"mutations":{"nuc":["C23854T"]}}},{"name":"B.1.1.205","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.205"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.205"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.790339946746826}},"branch_attrs":{"mutations":{"nuc":["G5539A","G21468A"],"nsp16":["M270I"]},"labels":{"aa":"nsp16: M270I"}}},{"name":"B.1.1.198","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.198"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.198"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.466243743896484}},"branch_attrs":{"mutations":{"nuc":["C3261T","A15984T","C20946T"],"nsp3":["T181I"]},"labels":{"aa":"nsp3: T181I"}}},{"name":"B.1.1.207","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.207"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.207"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.1433210372924805}},"branch_attrs":{"mutations":{"nuc":["T9172C","A10948G","C10977T","C23604A","A24874G","G26730T","A26927G"],"M":["V70F"],"S":["P681H"],"nsp6":["A2V"]},"labels":{"aa":"M: V70F; S: P681H; nsp6: A2V","spike_mutations":"P681H"}}},{"name":"B.1.1.231","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.231"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.231"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.254888534545898}},"branch_attrs":{"mutations":{"nuc":["A1G","A25505C"],"ORF3a":["Q38P"]},"labels":{"aa":"ORF3a: Q38P"}}},{"name":"B.1.1.232","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.232"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.232"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.283545970916748}},"branch_attrs":{"mutations":{"nuc":["T2537G","G12191T","T16479C"],"nsp2":["L578V"],"nsp8":["V34F"]},"labels":{"aa":"nsp2: L578V; nsp8: V34F"}}},{"name":"B.1.1.241","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.241"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.241"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.24725866317749}},"branch_attrs":{"mutations":{"nuc":["A11782G","T21570G","C21575T","T25473C","C28253T"],"S":["V3G","L5F"]},"labels":{"aa":"S: V3G, L5F","spike_mutations":"V3G, L5F"}}},{"name":"B.1.1.243","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.243"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.243"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.795328617095947}},"branch_attrs":{"mutations":{"nuc":["C5339T","A9900C","C12733A"],"nsp3":["P874S"],"nsp4":["N449T"]},"labels":{"aa":"nsp3: P874S; nsp4: N449T"}}},{"name":"B.1.1.228","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.228"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.228"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.376809597015381}},"branch_attrs":{"mutations":{"nuc":["A20288G","C21721T","C26894T","C28638A"],"N":["P122H"],"nsp15":["E223G"]},"labels":{"aa":"N: P122H; nsp15: E223G"}}},{"name":"B.1.1.253","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.253"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.253"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.5802154541015625}},"branch_attrs":{"mutations":{"nuc":["T19893C"]}}},{"name":"B.1.1.263","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.263"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.263"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.347754001617432}},"branch_attrs":{"mutations":{"nuc":["G5924A","T21775G"],"nsp3":["V1069I"]},"labels":{"aa":"nsp3: V1069I"}}},{"name":"B.1.1.265","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.265"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.265"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.463467121124268}},"branch_attrs":{"mutations":{"nuc":["C11005A","A28624T"],"nsp6":["H11Q"]},"labels":{"aa":"nsp6: H11Q"}}},{"name":"B.1.1.269","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.269"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.269"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.337708950042725}},"branch_attrs":{"mutations":{"nuc":["C5055T","G11851T","G24812T","C26895T"],"M":["H125Y"],"S":["D1084Y"],"nsp3":["T779I"],"nsp7":["M3I"]},"labels":{"aa":"M: H125Y; S: D1084Y; nsp3: T779I; nsp7: M3I","spike_mutations":"D1084Y"}}},{"name":"B.1.1.274","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.274"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.274"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.456281661987305}},"branch_attrs":{"mutations":{"nuc":["G25912T"],"ORF3a":["G174C"]},"labels":{"aa":"ORF3a: G174C"}}},{"name":"B.1.1.277","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.277"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.277"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.125593185424805}},"branch_attrs":{"mutations":{"nuc":["A1G","T772C","A2869G","C10868T","G15652T","C29095T"],"nsp12":["D738Y"]},"labels":{"aa":"nsp12: D738Y"}}},{"name":"B.1.1.294","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.294"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.294"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.174777507781982}},"branch_attrs":{"mutations":{"nuc":["C3373A","C6883T","G21724A"],"nsp3":["D218E"]},"labels":{"aa":"nsp3: D218E"}}},{"name":"B.1.1.297","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.297"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.297"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4372172355651855}},"branch_attrs":{"mutations":{"nuc":["A20742C","T27922C"],"ORF8":["I10T"],"nsp16":["Q28H"]},"labels":{"aa":"ORF8: I10T; nsp16: Q28H"}}},{"name":"B.1.1.298","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.298"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.298"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.08450984954834}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22920T","C25936T"],"ORF3a":["H182Y"],"S":["Y453F"],"nsp12":["T739I"]},"labels":{"aa":"ORF3a: H182Y; S: Y453F; nsp12: T739I","spike_mutations":"Y453F"}}},{"name":"B.1.1.307","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.307"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.307"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.859855890274048}},"branch_attrs":{"mutations":{"nuc":["G1210T","G9802T","G12067T"],"nsp2":["M135I"],"nsp7":["M75I"]},"labels":{"aa":"nsp2: M135I; nsp7: M75I"}}},{"name":"B.1.1.311","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.311"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.311"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.807455539703369}},"branch_attrs":{"mutations":{"nuc":["G11230T","T24088C","G25617T"],"ORF3a":["K75N"],"nsp6":["M86I"]},"labels":{"aa":"ORF3a: K75N; nsp6: M86I"}}},{"name":"B.1.1.329","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.329"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.329"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.522212982177734}},"branch_attrs":{"mutations":{"nuc":["A2132C","A10323G","G10360A"],"nsp2":["K443Q"],"nsp5":["K90R"]},"labels":{"aa":"nsp2: K443Q; nsp5: K90R"}}},{"name":"B.1.1.348","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.348"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.348"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.967780828475952}},"branch_attrs":{"mutations":{"nuc":["C25521T","C29870A"]}}},{"name":"B.1.1.359","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.359"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.359"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.396486759185791}},"branch_attrs":{"mutations":{"nuc":["A28305G"],"N":["N11S"],"ORF9b":["M8V"]},"labels":{"aa":"N: N11S; ORF9b: M8V"}}},{"name":"B.1.1.368","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.368"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.368"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.437197208404541}},"branch_attrs":{"mutations":{"nuc":["C9996T","G27798T","G29402T"],"N":["D377Y"],"ORF7b":["A15S"],"nsp4":["S481L"]},"labels":{"aa":"N: D377Y; ORF7b: A15S; nsp4: S481L"}}},{"name":"B.1.1.371","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.371"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.371"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.790440082550049}},"branch_attrs":{"mutations":{"nuc":["T16456C"],"nsp13":["S74P"]},"labels":{"aa":"nsp13: S74P"}}},{"name":"B.1.1.37","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.37"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.50777268409729}},"branch_attrs":{"mutations":{"nuc":["C21637T","A28169G"]}}},{"name":"B.1.1.370","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.370"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.370"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.376","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.376"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.376"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.82697057723999}},"branch_attrs":{"mutations":{"nuc":["A6716G","G11596T"],"nsp3":["S1333G"],"nsp6":["Q208H"]},"labels":{"aa":"nsp3: S1333G; nsp6: Q208H"}}},{"name":"B.1.1.374","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.374"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.374"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C344A","T1456C","C8595T","C8836T","G11222T","C22792T","T22917A","T26047G"],"ORF3a":["L219V"],"S":["L452Q"],"nsp1":["L27I"],"nsp4":["T14I"],"nsp6":["V84F"]},"labels":{"aa":"ORF3a: L219V; S: L452Q; nsp1: L27I; nsp4: T14I; nsp6: V84F","spike_mutations":"L452Q"}}},{"name":"B.1.1.378","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.378"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.378"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.7187089920043945}},"branch_attrs":{"mutations":{"nuc":["C29284T","C29870A"]}}},{"name":"B.1.1.39","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.39"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9360599517822266}},"branch_attrs":{"mutations":{"nuc":["G9130T","T27319C","G28487A","C28868T"],"N":["V72I","P199S"]},"labels":{"aa":"N: V72I, P199S"}}},{"name":"B.1.1.391","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.391"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.391"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.083807468414307}},"branch_attrs":{"mutations":{"nuc":["T7171C","C27002T"]}}},{"name":"B.1.1.398","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.398"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.398"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.421121597290039}},"branch_attrs":{"mutations":{"nuc":["C5806T"]}}},{"name":"B.1.1.409","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.409"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.409"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.404","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.404"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.404"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.653604507446289}},"branch_attrs":{"mutations":{"nuc":["T19275A","G20548T","G26211T","C26534T"],"nsp15":["D310Y"]},"labels":{"aa":"nsp15: D310Y"}}},{"name":"B.1.1.411","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.411"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.411"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.420","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.420"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.420"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.130832672119141}},"branch_attrs":{"mutations":{"nuc":["T847C","G3994T","C5178T","C5548T","A11451G","C13694T","T18132C","C21614T","T22882G","A24373G","G25839T","C28310T","T28862A"],"N":["P13S","S197T"],"ORF3a":["W149C"],"S":["L18F","N440K"],"nsp12":["T85I"],"nsp3":["T820I"],"nsp6":["Q160R"]},"labels":{"aa":"N: P13S, S197T; ORF3a: W149C; S: L18F, N440K; nsp12: T85I; nsp3: T820I; nsp6: Q160R","spike_mutations":"L18F, N440K"}}},{"name":"B.1.1.419","node_attrs":{"div":7,"Nextclade_pango":{"value":"B.1.1.419"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.419"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.255901336669922}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.432","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.432"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.432"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0862812995910645}},"branch_attrs":{"mutations":{"nuc":["A6985T","C9319T","C12412T","T14313C"]}}},{"name":"B.1.1.44","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.44"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.218751907348633}},"branch_attrs":{"mutations":{"nuc":["G28884T"],"N":["R204L"]},"labels":{"aa":"N: R204L"}}},{"name":"B.1.1.442","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.442"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.442"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.316291809082031}},"branch_attrs":{"mutations":{"nuc":["A3879-","G3880-","A3881-","T3882-","T3883-","C3884-","C3885-","T3886-","A3887-","A3888-","A3889-","G3890-","A3891-","G3892-","G3893-","A3894-","A3895-","G3896-","T3897-","T3898-","A3899-","A3900-","G3901-","C3902-","C3903-","A3904-","T3905-","T3906-","T3907-","A3908-","C13432T","C29409T"],"N":["T379I"],"nsp3":["E387-","I388-","P389-","K390-","E391-","E392-","V393-","K394-","P395-","F396-","I397V"]},"labels":{"aa":"N: T379I; nsp3: E387-, I388-, P389-, K390-, E391-, E392-, V393-, K394-, P395-, F396-, I397V"}}},{"name":"B.1.1.462","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.462"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.462"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.088257789611816}},"branch_attrs":{"mutations":{"nuc":["G23311T"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"B.1.1.485","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.485"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.485"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.902052879333496}},"branch_attrs":{"mutations":{"nuc":["C745T"]}}},{"name":"B.1.1.487","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.487"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.487"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.5293731689453125}},"branch_attrs":{"mutations":{"nuc":["A20374G"],"nsp15":["I252V"]},"labels":{"aa":"nsp15: I252V"}}},{"name":"B.1.1.500","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.500"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.500"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.359736442565918}},"branch_attrs":{"mutations":{"nuc":["T23689C","C29230T"]}}},{"name":"B.1.1.52","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.52"},"qc.stopCodons.totalStopCodons":{"value":1},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":56.25},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.52"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.176274299621582}},"branch_attrs":{"mutations":{"nuc":["G8T","T9C","A12T","T14222G","T29867A"],"nsp12":["L261*"]},"labels":{"aa":"nsp12: L261*"}}},{"name":"B.1.1.525","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.525"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":4},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.525"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1C","T2C","T3478G","C8299T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12781T","A16550C","C16887T","C18252T","T21992-","A21993-","T21994-","G23012A","C23525T","A28271C","G28916T"],"N":["G215C"],"S":["Y144-","E484K","H655Y"],"nsp13":["D105A"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: G215C; S: Y144-, E484K, H655Y; nsp13: D105A; nsp6: S106-, G107-, F108-","spike_mutations":"Y144-, E484K, H655Y"}}},{"name":"B.1.1.53","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.53"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.88819694519043}},"branch_attrs":{"mutations":{"nuc":["G9890T","A20318G"],"nsp15":["E233G"],"nsp4":["A446S"]},"labels":{"aa":"nsp15: E233G; nsp4: A446S"}}},{"name":"B.1.1.57","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.57"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.502486705780029}},"branch_attrs":{"mutations":{"nuc":["C20234T"],"nsp15":["P205L"]},"labels":{"aa":"nsp15: P205L"}}},{"name":"B.1.1.63","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.63"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7540249824523926}},"branch_attrs":{"mutations":{"nuc":["C21597T","C29144T"],"S":["S12F"]},"labels":{"aa":"S: S12F","spike_mutations":"S12F"}}},{"name":"B.1.1.61","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.61"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.910613059997559}},"branch_attrs":{"mutations":{"nuc":["G18898T"],"nsp14":["V287F"]},"labels":{"aa":"nsp14: V287F"}}},{"name":"B.1.1.83","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.83"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.83"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.403122901916504}},"branch_attrs":{"mutations":{"nuc":["C1420T"]}}},{"name":"B.1.1.99","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.99"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.99"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.924996376037598}},"branch_attrs":{"mutations":{"nuc":["C28005T","C29870A"],"ORF8":["P38S"]},"labels":{"aa":"ORF8: P38S"}}},{"name":"B.1.533","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.533"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.533"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.071420192718506}},"branch_attrs":{"mutations":{"nuc":["G25563T"],"ORF3a":["Q57H"]},"labels":{"aa":"ORF3a: Q57H"}}},{"name":"NODE_0000590","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.10"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.221151828765869}},"branch_attrs":{"mutations":{"nuc":["C19170T","G19509A"]}},"children":[{"name":"B.1.1.10","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.221151828765869}},"branch_attrs":{"mutations":{}}},{"name":"L.3","node_attrs":{"div":20,"Nextclade_pango":{"value":"L.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.10.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.097338676452637}},"branch_attrs":{"mutations":{"nuc":["C1601T","G4399T","C4543T","G8179T","C8481T","A9453C","C19269T","T22917G","A25026T","G25244T","A26927G"],"S":["L452R","Y1155F","V1228L"],"nsp2":["L266F"],"nsp3":["M560I","P1921L"],"nsp4":["Y300S"]},"labels":{"aa":"S: L452R, Y1155F, V1228L; nsp2: L266F; nsp3: M560I, P1921L; nsp4: Y300S","spike_mutations":"L452R, Y1155F, V1228L"}}}]},{"name":"NODE_0000591","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.131749153137207}},"branch_attrs":{"mutations":{"nuc":["C13887T","C23248T"]}},"children":[{"name":"B.1.1.153","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.153"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.153"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.293111324310303}},"branch_attrs":{"mutations":{"nuc":["C1912T","T9151C","C9693T","T16456C"],"nsp13":["S74P"],"nsp4":["A380V"]},"labels":{"aa":"nsp13: S74P; nsp4: A380V"}}},{"name":"B.1.1.170","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.170"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.170"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.35718297958374}},"branch_attrs":{"mutations":{"nuc":["C2062T","C5184A","C18687T"],"nsp3":["P822H"]},"labels":{"aa":"nsp3: P822H"}}}]},{"name":"NODE_0000592","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.607780456542969}},"branch_attrs":{"mutations":{"nuc":["C9120T"],"nsp4":["T189I"]},"labels":{"aa":"nsp4: T189I"}},"children":[{"name":"B.1.1.159","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.159"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.159"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.915672302246094}},"branch_attrs":{"mutations":{"nuc":["G6865T","A9204C","C15237T","C28290T"],"N":["P6L"],"ORF9b":["P3S"],"nsp3":["K1382N"],"nsp4":["D217A"]},"labels":{"aa":"N: P6L; ORF9b: P3S; nsp3: K1382N; nsp4: D217A"}}},{"name":"B.1.1.302","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.302"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.302"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4443230628967285}},"branch_attrs":{"mutations":{"nuc":["C7267T","C18032T","C20233T","G24926T","A27674T","A29350G"],"ORF7a":["Q94L"],"S":["V1122L"],"nsp13":["T599I"],"nsp15":["P205S"]},"labels":{"aa":"ORF7a: Q94L; S: V1122L; nsp13: T599I; nsp15: P205S","spike_mutations":"V1122L"}}}]},{"name":"NODE_0000593","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.96992301940918}},"branch_attrs":{"mutations":{"nuc":["C1427T"],"nsp2":["H208Y"]},"labels":{"aa":"nsp2: H208Y"}},"children":[{"name":"B.1.1.254","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.254"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.254"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.96992301940918}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.507","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.507"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.507"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["G1042A","C12253T","G19656A"]}}}]},{"name":"NODE_0000594","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.194224834442139}},"branch_attrs":{"mutations":{"nuc":["G21624T"],"S":["R21I"]},"labels":{"aa":"S: R21I","spike_mutations":"R21I"}},"children":[{"name":"B.1.1.279","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.279"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.279"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.194469928741455}},"branch_attrs":{"mutations":{"nuc":["C1419T","C4158T","C8318A","G18859T"],"nsp14":["A274S"],"nsp2":["A205V"],"nsp3":["A480V","P1867T"]},"labels":{"aa":"nsp14: A274S; nsp2: A205V; nsp3: A480V, P1867T"}}},{"name":"B.1.1.360","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.360"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.360"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.070964336395264}},"branch_attrs":{"mutations":{"nuc":["G25598T"],"ORF3a":["W69L"]},"labels":{"aa":"ORF3a: W69L"}}}]},{"name":"NODE_0000595","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.927735328674316}},"branch_attrs":{"mutations":{"nuc":["C936T","G3259T"],"nsp2":["T44I"],"nsp3":["Q180H"]},"labels":{"aa":"nsp2: T44I; nsp3: Q180H"}},"children":[{"name":"B.1.1.304","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.304"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.304"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.927735328674316}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.434","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.434"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.434"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2342G","C11591T","G17122T","C18348T","A26069G"],"ORF3a":["E226G"],"nsp13":["A296S"],"nsp2":["I513V"],"nsp6":["L207F"]},"labels":{"aa":"ORF3a: E226G; nsp13: A296S; nsp2: I513V; nsp6: L207F"}}}]},{"name":"NODE_0000596","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.98975133895874}},"branch_attrs":{"mutations":{"nuc":["C25528T"],"ORF3a":["L46F"]},"labels":{"aa":"ORF3a: L46F"}},"children":[{"name":"B.1.1.326","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.326"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.326"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.312747478485107}},"branch_attrs":{"mutations":{"nuc":["A12C","G4354A","C6573T"],"nsp3":["S1285F"]},"labels":{"aa":"nsp3: S1285F"}}},{"name":"B.1.1.8","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.8"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.98975133895874}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000597","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.590047836303711}},"branch_attrs":{"mutations":{"nuc":["A1G","C12053T","G25088T"],"S":["V1176F"],"nsp7":["L71F"]},"labels":{"aa":"S: V1176F; nsp7: L71F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.332","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.332"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.332"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["C442A","C6310T","G11417T","T16944C","G26062C"],"ORF3a":["G224R"],"nsp6":["V149F"]},"labels":{"aa":"ORF3a: G224R; nsp6: V149F"}}},{"name":"P.7","node_attrs":{"div":21,"Nextclade_pango":{"value":"P.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":13},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.7"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C1288T","C7124T","C7765T","G8027T","C9344T","G10870T","G11596T","C17172T","C17676T","C25844T","C28311T"],"N":["P13L"],"ORF3a":["T151I"],"ORF9b":["P10S"],"nsp3":["P1469S","V1770F"],"nsp4":["L264F"],"nsp6":["Q208H"]},"labels":{"aa":"N: P13L; ORF3a: T151I; ORF9b: P10S; nsp3: P1469S, V1770F; nsp4: L264F; nsp6: Q208H"}}}]},{"name":"NODE_0000598","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9660351276397705}},"branch_attrs":{"mutations":{"nuc":["G21974T"],"S":["D138Y"]},"labels":{"aa":"S: D138Y","spike_mutations":"D138Y"}},"children":[{"name":"B.1.1.397","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.397"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.397"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.451379776000977}},"branch_attrs":{"mutations":{"nuc":["T22020C","G28077T","G28975T"],"N":["M234I"],"ORF8":["V62L"],"S":["M153T"]},"labels":{"aa":"N: M234I; ORF8: V62L; S: M153T","spike_mutations":"M153T"}}},{"name":"B.1.1.413","node_attrs":{"div":16,"Nextclade_pango":{"value":"B.1.1.413"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.413"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["A604G","C3096T","G13849T","A19020T","G22992A","A26741G","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","C28291T","C29311T"],"M":["I73M"],"ORF8":["G66-","S67-","K68E"],"ORF9b":["P3L"],"S":["S477N"],"nsp12":["G137C"],"nsp3":["S126L"]},"labels":{"aa":"M: I73M; ORF8: G66-, S67-, K68E; ORF9b: P3L; S: S477N; nsp12: G137C; nsp3: S126L","spike_mutations":"S477N"}}}]},{"name":"NODE_0000599","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.683711051940918}},"branch_attrs":{"mutations":{"nuc":["T12503C","C29721T"],"nsp8":["Y138H"]},"labels":{"aa":"nsp8: Y138H"}},"children":[{"name":"B.1.1.448","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.448"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.448"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.683711051940918}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.54","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.54"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.678201675415039}},"branch_attrs":{"mutations":{"nuc":["C6762T","G25770T"],"ORF3a":["R126S"],"nsp3":["T1348I"]},"labels":{"aa":"ORF3a: R126S; nsp3: T1348I"}}}]},{"name":"NODE_0000600","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.747574806213379}},"branch_attrs":{"mutations":{"nuc":["C21648T"],"S":["T29I"]},"labels":{"aa":"S: T29I","spike_mutations":"T29I"}},"children":[{"name":"B.1.1.486","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.486"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.486"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["C12439T","C23277T","G23593T","G24368A","G25565A","C25624T","T27242C","C27630T","G28975T","G29332T","G29751T"],"N":["M234I"],"ORF3a":["S58N","H78Y"],"ORF6":["I14T"],"S":["T572I","Q677H","D936N"]},"labels":{"aa":"N: M234I; ORF3a: S58N, H78Y; ORF6: I14T; S: T572I, Q677H, D936N","spike_mutations":"T572I, Q677H, D936N"}}},{"name":"B.1.1.67","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.67"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.898261547088623}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"nsp6":["D159N"]},"labels":{"aa":"nsp6: D159N"}}}]},{"name":"NODE_0000601","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.247831344604492}},"branch_attrs":{"mutations":{"nuc":["C26060T"],"ORF3a":["T223I"]},"labels":{"aa":"ORF3a: T223I"}},"children":[{"name":"B.1.1.216","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.216"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.216"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.874875545501709}},"branch_attrs":{"mutations":{"nuc":["A1T","C5884T"]}}},{"name":"B.1.1.416","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.416"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.416"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.05353307723999}},"branch_attrs":{"mutations":{"nuc":["C16386T","C20762T"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"B.1.1.433","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.433"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.433"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.377383708953857}},"branch_attrs":{"mutations":{"nuc":["C313T","G3692T","C5007T","A11991G","G14584A","C14805T","T15114C","C15848T","G20940T","C22993G","G23580C","T23599A","G26217T","G26951C","T27900C"],"ORF3a":["L275F"],"ORF8":["F3L"],"S":["S477R","S673T","N679K"],"nsp12":["A382T","T803I"],"nsp3":["V325F","T763M"],"nsp7":["E50G"]},"labels":{"aa":"ORF3a: L275F; ORF8: F3L; S: S477R, S673T, N679K; nsp12: A382T, T803I; nsp3: V325F, T763M; nsp7: E50G","spike_mutations":"S477R, S673T, N679K"}}}]},{"name":"NODE_0000602","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.30653190612793}},"branch_attrs":{"mutations":{"nuc":["G10265A"],"nsp5":["G71S"]},"labels":{"aa":"nsp5: G71S"}},"children":[{"name":"B.1.1.27","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.27"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.767889499664307}},"branch_attrs":{"mutations":{"nuc":["C16293T"]}}},{"name":"B.1.1.301","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.301"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.301"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.301366329193115}},"branch_attrs":{"mutations":{"nuc":["A9433T","A19650G"]}}},{"name":"B.1.1.70","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.70"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.70"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.566112756729126}},"branch_attrs":{"mutations":{"nuc":["A15972G","C19718T","T28759C"],"nsp15":["T33I"]},"labels":{"aa":"nsp15: T33I"}}}]},{"name":"NODE_0000603","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.859383583068848}},"branch_attrs":{"mutations":{"nuc":["C22675T"]}},"children":[{"name":"B.1.1.273","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.273"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.273"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.873911380767822}},"branch_attrs":{"mutations":{"nuc":["A7064G"],"nsp3":["R1449G"]},"labels":{"aa":"nsp3: R1449G"}}},{"name":"B.1.1.412","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.412"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.412"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.9886064529418945}},"branch_attrs":{"mutations":{"nuc":["G11447A"],"nsp6":["D159N"]},"labels":{"aa":"nsp6: D159N"}}},{"name":"B.1.1.56","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.56"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["T9508C","G23868T","G24794T"],"S":["G769V","A1078S"]},"labels":{"aa":"S: G769V, A1078S","spike_mutations":"G769V, A1078S"}}}]},{"name":"NODE_0000604","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.898122787475586}},"branch_attrs":{"mutations":{"nuc":["G11083T"],"nsp6":["L37F"]},"labels":{"aa":"nsp6: L37F"}},"children":[{"name":"B.1.1.312","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.312"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.312"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420844554901123}},"branch_attrs":{"mutations":{"nuc":["C2455T","C14625T","C19018T","A24432T","A28081G"],"ORF8":["D63G"],"S":["Q957L"],"nsp14":["P327S"]},"labels":{"aa":"ORF8: D63G; S: Q957L; nsp14: P327S","spike_mutations":"Q957L"}}},{"name":"B.1.1.406","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.406"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.406"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.8544087409973145}},"branch_attrs":{"mutations":{"nuc":["C683T","C7051T","C7303T","C8964T","G25314T","C29296T","G29744A"],"S":["G1251V"],"nsp4":["S137L"]},"labels":{"aa":"S: G1251V; nsp4: S137L","spike_mutations":"G1251V"}}},{"name":"B.1.1.417","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.417"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.417"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.553451061248779}},"branch_attrs":{"mutations":{"nuc":["A2871G","C11455T","T12433C","C16997T","C17285T","A17739G","C19017T","G19072T","C20823T","G21800T","C25416T","G29781T"],"S":["D80Y"],"nsp13":["P254L","S350L"],"nsp14":["D345Y"],"nsp3":["N51S"]},"labels":{"aa":"S: D80Y; nsp13: P254L, S350L; nsp14: D345Y; nsp3: N51S","spike_mutations":"D80Y"}}}]},{"name":"NODE_0000605","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.167232036590576}},"branch_attrs":{"mutations":{"nuc":["G16853T"],"nsp13":["G206V"]},"labels":{"aa":"nsp13: G206V"}},"children":[{"name":"B.1.1.382","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.382"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.382"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.60129451751709}},"branch_attrs":{"mutations":{"nuc":["G6368A"],"nsp3":["G1217R"]},"labels":{"aa":"nsp3: G1217R"}}},{"name":"NODE_0000606","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.467953205108643}},"branch_attrs":{"mutations":{"nuc":["C2094T"],"nsp2":["S430L"]},"labels":{"aa":"nsp2: S430L"}},"children":[{"name":"B.1.1.34","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.34"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.467953205108643}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.528","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.528"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.528"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["A1072G","C1449T","A3868T","G9526T","G9756A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21974T","T22912G","C23604G","T26767C","C27297T","A28877T","G28878C","A28911T","C29303T"],"M":["I82T"],"N":["N213I","P344S"],"S":["D138Y","N450K","P681R"],"nsp2":["T215I"],"nsp3":["Q383H"],"nsp4":["M324I","R401H"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"M: I82T; N: N213I, P344S; S: D138Y, N450K, P681R; nsp2: T215I; nsp3: Q383H; nsp4: M324I, R401H; nsp6: S106-, G107-, F108-","spike_mutations":"D138Y, N450K, P681R"}}}]}]},{"name":"NODE_0000607","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.25"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.116090297698975}},"branch_attrs":{"mutations":{"nuc":["A1G","A1163T"],"nsp2":["I120F"]},"labels":{"aa":"nsp2: I120F"}},"children":[{"name":"B.1.1.25","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.25"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.116090297698975}},"branch_attrs":{"mutations":{}}},{"name":"D.2","node_attrs":{"div":14,"Nextclade_pango":{"value":"D.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20F"},"partiallyAliased":{"value":"B.1.1.25.2"},"clade_nextstrain":{"value":"20F"},"clade_membership":{"value":"20F"},"placement_prior":{"value":-3.0833327770233154}},"branch_attrs":{"mutations":{"nuc":["T7540C","G16647T","C18555T","G22992A","G23401A"],"S":["S477N"]},"labels":{"aa":"S: S477N","clade":"20F","spike_mutations":"S477N"}}},{"name":"NODE_0000608","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.315"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{"nuc":["G1A","T3256C","G14202T","C19718T","C22388T","C26060T","G29227T","C29466T","A29771G"],"N":["A398V"],"ORF3a":["T223I"],"nsp12":["E254D"],"nsp15":["T33I"]},"labels":{"aa":"N: A398V; ORF3a: T223I; nsp12: E254D; nsp15: T33I"}},"children":[{"name":"AD.2","node_attrs":{"div":20,"Nextclade_pango":{"value":"AD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.5890538692474365}},"branch_attrs":{"mutations":{"nuc":["C5622T","G19542T"],"nsp14":["M501I"],"nsp3":["P968L"]},"labels":{"aa":"nsp14: M501I; nsp3: P968L"}}},{"name":"B.1.1.315","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.315"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.315"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000609","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.680613994598389}},"branch_attrs":{"mutations":{"nuc":["C8917T"]}},"children":[{"name":"B.1.1.351","node_attrs":{"div":18,"Nextclade_pango":{"value":"B.1.1.351"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.351"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["C7231T","A9749G","C10776A","A13867C","A15489G","C16658T","G17815A","C19164T","G21724T","C23604A"],"S":["L54F","P681H"],"nsp12":["K143Q"],"nsp13":["T141I","G527R"],"nsp4":["K399E"],"nsp5":["P241H"]},"labels":{"aa":"S: L54F, P681H; nsp12: K143Q; nsp13: T141I, G527R; nsp4: K399E; nsp5: P241H","spike_mutations":"L54F, P681H"}}},{"name":"B.1.1.46","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.46"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.398571014404297}},"branch_attrs":{"mutations":{"nuc":["A1C","C1218T","C27110T","T27384C"],"nsp2":["S138L"]},"labels":{"aa":"nsp2: S138L"}}},{"name":"NODE_0000610","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8004047870635986}},"branch_attrs":{"mutations":{"nuc":["G9389A"],"nsp4":["D279N"]},"labels":{"aa":"nsp4: D279N"}},"children":[{"name":"B.1.1.354","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.354"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.354"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.217127323150635}},"branch_attrs":{"mutations":{"nuc":["A1T","G28899T"],"N":["R209I"]},"labels":{"aa":"N: R209I"}}},{"name":"B.1.1.526","node_attrs":{"div":19,"Nextclade_pango":{"value":"B.1.1.526"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.526"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-8.332109451293945}},"branch_attrs":{"mutations":{"nuc":["G4510T","C9611T","G12167T","G14622A","C23604A","T24811C","G25250T","G25906T","G28077T","C29659T"],"ORF3a":["G172C"],"ORF8":["V62L"],"S":["P681H","V1230L"],"nsp4":["L353F"],"nsp8":["V26F"]},"labels":{"aa":"ORF3a: G172C; ORF8: V62L; S: P681H, V1230L; nsp4: L353F; nsp8: V26F","spike_mutations":"P681H, V1230L"}}}]}]},{"name":"NODE_0000611","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.33"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8493027687072754}},"branch_attrs":{"mutations":{"nuc":["T27299C","T29148C"],"N":["I292T"],"ORF6":["I33T"]},"labels":{"aa":"N: I292T; ORF6: I33T"}},"children":[{"name":"B.1.1.33","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8493027687072754}},"branch_attrs":{"mutations":{}}},{"name":"N.6","node_attrs":{"div":11,"Nextclade_pango":{"value":"N.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.6"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.92036771774292}},"branch_attrs":{"mutations":{"nuc":["C5365T","G8137T"]}}},{"name":"N.3","node_attrs":{"div":10,"Nextclade_pango":{"value":"N.3"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.329464435577393}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"N.4","node_attrs":{"div":11,"Nextclade_pango":{"value":"N.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.656524181365967}},"branch_attrs":{"mutations":{"nuc":["A1C","A2475G"],"nsp2":["K557R"]},"labels":{"aa":"nsp2: K557R"}}},{"name":"N.5","node_attrs":{"div":14,"Nextclade_pango":{"value":"N.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A298G","C17274T","A22803G","C25904T","G29134A"],"ORF3a":["S171L"],"S":["Q414R"]},"labels":{"aa":"ORF3a: S171L; S: Q414R","spike_mutations":"Q414R"}}},{"name":"N.9","node_attrs":{"div":16,"Nextclade_pango":{"value":"N.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.33.9"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.921331882476807}},"branch_attrs":{"mutations":{"nuc":["G1264T","C7600T","C7851T","T11078C","G23012A","A27853C","A29882C"],"ORF7b":["E33A"],"S":["E484K"],"nsp3":["A1711V"],"nsp6":["F36L"]},"labels":{"aa":"ORF7b: E33A; S: E484K; nsp3: A1711V; nsp6: F36L","spike_mutations":"E484K"}}}]},{"name":"NODE_0000612","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.592955112457275}},"branch_attrs":{"mutations":{"nuc":["G23012A","T26767C"],"M":["I82T"],"S":["E484K"]},"labels":{"aa":"M: I82T; S: E484K","spike_mutations":"E484K"}},"children":[{"name":"B.1.1.523","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.1.523"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.523"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["A1087G","A1610G","A2311G","A2969G","G6609T","C9430T","G10961A","G11222T","C13356T","G14126A","C16466T","G16917A","G22028-","A22029-","G22030-","T22031-","T22032-","C22033-","A22034-","G22035-","A22036-","T22478C","T23042C","A23901C","A24078T","C24642T","C25904T","G25993T","A28273T","G28907T"],"N":["G212C"],"ORF3a":["S171L","V201F"],"S":["E156-","F157-","R158-","F306L","S494P","E780A","D839V","T1027I"],"nsp10":["T111I"],"nsp12":["S229N"],"nsp13":["P77L"],"nsp2":["N269D"],"nsp3":["M84V","R1297I"],"nsp5":["V303I"],"nsp6":["V84F"]},"labels":{"aa":"N: G212C; ORF3a: S171L, V201F; S: E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I; nsp10: T111I; nsp12: S229N; nsp13: P77L; nsp2: N269D; nsp3: M84V, R1297I; nsp5: V303I; nsp6: V84F","spike_mutations":"E156-, F157-, R158-, F306L, S494P, E780A, D839V, T1027I"}}},{"name":"NODE_0000613","node_attrs":{"div":23,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A1T","C3961T","G7798T","C9072T","C9891T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G20578A","C21846T","T21992-","A21993-","T21994-","T23287C","C23604A","G23948C","C25276A","A27887-","A27888-","C27889-","G27890-","A27891-","A27892-","C27893-","A27894-","T27895-","G27896-","A27897-","A27898-","A27899-","T27900-","T27901-","G28209T","A28271G","C28896-","T28897-","A28898-","C29769T"],"N":["A208-","R209G"],"ORF8":["E106*"],"S":["T95I","Y144-","P681H","D796H"],"nsp15":["V320M"],"nsp3":["K1693N"],"nsp4":["T173I","A446V"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: A208-, R209G; ORF8: E106*; S: T95I, Y144-, P681H, D796H; nsp15: V320M; nsp3: K1693N; nsp4: T173I, A446V; nsp6: S106-, G107-, F108-","spike_mutations":"T95I, Y144-, P681H, D796H"}},"children":[{"name":"AZ.4","node_attrs":{"div":28,"Nextclade_pango":{"value":"AZ.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":17},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2416T","G7829C","T7831A","C17569T","T27384C"],"nsp13":["P445S"],"nsp3":["V1704L"]},"labels":{"aa":"nsp13: P445S; nsp3: V1704L"}}},{"name":"NODE_0000614","node_attrs":{"div":24,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C24382T"]}},"children":[{"name":"AZ.5","node_attrs":{"div":30,"Nextclade_pango":{"value":"AZ.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T1G","G3259T","G6463T","T20994C","C29077T","A29879G"],"nsp3":["Q180H"]},"labels":{"aa":"nsp3: Q180H"}}},{"name":"NODE_0000615","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.047244071960449}},"branch_attrs":{"mutations":{"nuc":["C10116T"],"nsp5":["T21I"]},"labels":{"aa":"nsp5: T21I"}},"children":[{"name":"B.1.1.318","node_attrs":{"div":25,"Nextclade_pango":{"value":"B.1.1.318"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.047244071960449}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000616","node_attrs":{"div":27,"Nextclade_pango":{"value":"B.1.1.318"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9885480403900146}},"branch_attrs":{"mutations":{"nuc":["A3852T","G21004T"],"nsp16":["A116S"],"nsp3":["E378V"]},"labels":{"aa":"nsp16: A116S; nsp3: E378V"}},"children":[{"name":"AZ.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"AZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.056199073791504}},"branch_attrs":{"mutations":{"nuc":["C10369T","C12400T","G28975T"],"N":["M234I"]},"labels":{"aa":"N: M234I"}}},{"name":"AZ.3","node_attrs":{"div":28,"Nextclade_pango":{"value":"AZ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.3"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["T11850C"],"nsp7":["M3T"]},"labels":{"aa":"nsp7: M3T"}}},{"name":"AZ.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"AZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":8},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.318.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.071262836456299}},"branch_attrs":{"mutations":{"nuc":["C11345T","C11644T"],"nsp6":["L125F"]},"labels":{"aa":"nsp6: L125F"}}}]}]}]}]}]},{"name":"NODE_0000617","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7063244581222534}},"branch_attrs":{"mutations":{"nuc":["C913T","C3267T","C5388A","C5986T","T6954C","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C14676T","C15279T","T16176C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","A23063T","C23271A","C23604A","C23709T","T24506G","G24914C","C27972T","G28048T","A28111G","A28271-","G28280C","A28281T","T28282A","C28977T"],"N":["D3L","S235F"],"ORF8":["Q27*","R52I","Y73C"],"S":["H69-","V70-","Y144-","N501Y","A570D","P681H","T716I","S982A","D1118H"],"nsp3":["T183I","A890D","I1412T"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: D3L, S235F; ORF8: Q27*, R52I, Y73C; S: H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H; nsp3: T183I, A890D, I1412T; nsp6: S106-, G107-, F108-","clade":"Alpha","spike_mutations":"H69-, V70-, Y144-, N501Y, A570D, P681H, T716I, S982A, D1118H"}},"children":[{"name":"B.1.1.7","node_attrs":{"div":28,"Nextclade_pango":{"value":"B.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7063244581222534}},"branch_attrs":{"mutations":{}}},{"name":"Q.1","node_attrs":{"div":29,"Nextclade_pango":{"value":"Q.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.1"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.273303270339966}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}}},{"name":"Q.2","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.2"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.956664800643921}},"branch_attrs":{"mutations":{"nuc":["A1752G","C6636T","G22468T","C25626T","C27752T","C28227T"],"ORF7a":["T120I"],"ORF8":["H112Y"],"nsp2":["Y316C"],"nsp3":["T1306I"]},"labels":{"aa":"ORF7a: T120I; ORF8: H112Y; nsp2: Y316C; nsp3: T1306I"}}},{"name":"NODE_0000618","node_attrs":{"div":30,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.7612149715423584}},"branch_attrs":{"mutations":{"nuc":["T15096C","A28095T"],"ORF8":["K68*"]},"labels":{"aa":"ORF8: K68*"}},"children":[{"name":"Q.7","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.1349856853485107}},"branch_attrs":{"mutations":{"nuc":["A7069C","A17337G","T18018C","G28884C"],"N":["R204P"],"nsp3":["E1450D"]},"labels":{"aa":"N: R204P; nsp3: E1450D"}}},{"name":"Q.8","node_attrs":{"div":35,"Nextclade_pango":{"value":"Q.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.8"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-4.827495098114014}},"branch_attrs":{"mutations":{"nuc":["C12525T","C19164T","C25096T","A25974C","G29751T"],"ORF3a":["E194D"],"nsp8":["T145I"]},"labels":{"aa":"ORF3a: E194D; nsp8: T145I"}}}]},{"name":"NODE_0000619","node_attrs":{"div":29,"Nextclade_pango":{"value":"B.1.1.7"},"clade_who":{"value":"Alpha"},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-1.8349626064300537}},"branch_attrs":{"mutations":{"nuc":["A17615G"],"nsp13":["K460R"]},"labels":{"aa":"nsp13: K460R"}},"children":[{"name":"Q.3","node_attrs":{"div":33,"Nextclade_pango":{"value":"Q.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.3"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.3964552879333496}},"branch_attrs":{"mutations":{"nuc":["G5023A","G10396T","G20962A","G26730C"],"M":["V70L"],"nsp16":["D102N"],"nsp3":["M768I"]},"labels":{"aa":"M: V70L; nsp16: D102N; nsp3: M768I"}}},{"name":"Q.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"Q.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Alpha"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20I (Alpha)"},"partiallyAliased":{"value":"B.1.1.7.4"},"clade_nextstrain":{"value":"20I"},"clade_membership":{"value":"20I"},"placement_prior":{"value":-3.756404399871826}},"branch_attrs":{"mutations":{"nuc":["C335T","A4964G","C7224T","A12162G","A23604G"],"S":["H681R"],"nsp1":["R24C"],"nsp3":["T749A","A1502V"],"nsp8":["Q24R"]},"labels":{"aa":"S: H681R; nsp1: R24C; nsp3: T749A, A1502V; nsp8: Q24R","spike_mutations":"H681R"}}}]}]},{"name":"NODE_0000620","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.3051984310150146}},"branch_attrs":{"mutations":{"nuc":["C313T"]}},"children":[{"name":"B.1.1.181","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.181"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.181"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.882091045379639}},"branch_attrs":{"mutations":{"nuc":["C14724T"]}}},{"name":"B.1.1.214","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.214"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.214"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-2.8961424827575684}},"branch_attrs":{"mutations":{"nuc":["C18167T","G21518T","G28975T"],"N":["M234I"],"nsp14":["P43L"],"nsp16":["R287I"]},"labels":{"aa":"N: M234I; nsp14: P43L; nsp16: R287I"}}},{"name":"B.1.1.305","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.305"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.305"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.704046726226807}},"branch_attrs":{"mutations":{"nuc":["G28396A"],"ORF9b":["G38D"]},"labels":{"aa":"ORF9b: G38D"}}},{"name":"B.1.1.50","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.50"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.179980754852295}},"branch_attrs":{"mutations":{"nuc":["G4510A","G15438T","G25785T"],"ORF3a":["W131C"],"nsp12":["M666I"]},"labels":{"aa":"ORF3a: W131C; nsp12: M666I"}}},{"name":"B.1.1.51","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.51"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.484864234924316}},"branch_attrs":{"mutations":{"nuc":["T10453C","C11195T"],"nsp6":["L75F"]},"labels":{"aa":"nsp6: L75F"}}},{"name":"NODE_0000621","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.787297248840332}},"branch_attrs":{"mutations":{"nuc":["C9286T"]}},"children":[{"name":"B.1.1.284","node_attrs":{"div":14,"Nextclade_pango":{"value":"B.1.1.284"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.284"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.2298262119293213}},"branch_attrs":{"mutations":{"nuc":["T4346C","C10376T","C14708T","C28725T","G29692T"],"N":["P151L"],"nsp12":["A423V"],"nsp3":["S543P"],"nsp5":["P108S"]},"labels":{"aa":"N: P151L; nsp12: A423V; nsp3: S543P; nsp5: P108S"}}},{"name":"B.1.1.47","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.47"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.770909309387207}},"branch_attrs":{"mutations":{"nuc":["C19763T"],"nsp15":["T48I"]},"labels":{"aa":"nsp15: T48I"}}}]},{"name":"NODE_0000622","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.306"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0954976081848145}},"branch_attrs":{"mutations":{"nuc":["A1C","C5700A"],"nsp3":["A994D"]},"labels":{"aa":"nsp3: A994D"}},"children":[{"name":"AE.8","node_attrs":{"div":15,"Nextclade_pango":{"value":"AE.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306.8"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9437592029571533}},"branch_attrs":{"mutations":{"nuc":["C1347T","C1943T","C6031T","T7153C","G13975T"],"nsp12":["G179C"],"nsp2":["P181L","R380C"]},"labels":{"aa":"nsp12: G179C; nsp2: P181L, R380C"}}},{"name":"AE.1","node_attrs":{"div":11,"Nextclade_pango":{"value":"AE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.030422210693359}},"branch_attrs":{"mutations":{"nuc":["C25791T"]}}},{"name":"B.1.1.306","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.306"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.306"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.0954976081848145}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000623","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.4629838466644287}},"branch_attrs":{"mutations":{"nuc":["T19839C"]}},"children":[{"name":"B.1.1.221","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.221"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.221"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.094820976257324}},"branch_attrs":{"mutations":{"nuc":["C21646T","C26846T"]}}},{"name":"B.1.1.220","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.220"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.220"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.65780782699585}},"branch_attrs":{"mutations":{"nuc":["C26681T"]}}},{"name":"B.1.1.291","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.291"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.291"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.9559080600738525}},"branch_attrs":{"mutations":{"nuc":["C15933T","C29784T"]}}},{"name":"B.1.1.316","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.316"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.316"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.084707736968994}},"branch_attrs":{"mutations":{"nuc":["C21757T","G23593C","A23756T","G29751T"],"S":["Q677H","T732S"]},"labels":{"aa":"S: Q677H, T732S","spike_mutations":"Q677H, T732S"}}},{"name":"B.1.1.317","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.317"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.317"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.8110387325286865}},"branch_attrs":{"mutations":{"nuc":["C28905T"],"N":["A211V"]},"labels":{"aa":"N: A211V"}}},{"name":"B.1.1.459","node_attrs":{"div":11,"Nextclade_pango":{"value":"B.1.1.459"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.459"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.982537269592285}},"branch_attrs":{"mutations":{"nuc":["C16971T","A21137G","C24099T"],"S":["A846V"],"nsp16":["K160R"]},"labels":{"aa":"S: A846V; nsp16: K160R","spike_mutations":"A846V"}}},{"name":"B.1.1.464","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.464"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":4},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.464"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.04607629776001}},"branch_attrs":{"mutations":{"nuc":["C12025T","C23707T"]}}},{"name":"B.1.1.521","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.521"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.521"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.155294418334961}},"branch_attrs":{"mutations":{"nuc":["C4927T","C9693T","C18744T","C23422T"],"nsp4":["A380V"]},"labels":{"aa":"nsp4: A380V"}}},{"name":"R.1","node_attrs":{"div":20,"Nextclade_pango":{"value":"R.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.316.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.117560863494873}},"branch_attrs":{"mutations":{"nuc":["C14340T","G17551A","C18877T","A19167G","C19274A","G22017T","G23012A","G23868T","T26604C","C27213T","C28833T","G29527T"],"M":["F28L"],"N":["S187L","Q418H"],"S":["W152L","E484K","G769V"],"nsp13":["G439R"],"nsp14":["P412H"]},"labels":{"aa":"M: F28L; N: S187L, Q418H; S: W152L, E484K, G769V; nsp13: G439R; nsp14: P412H","spike_mutations":"W152L, E484K, G769V"}}},{"name":"NODE_0000624","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.707209348678589}},"branch_attrs":{"mutations":{"nuc":["A23756G"],"S":["T732A"]},"labels":{"aa":"S: T732A","spike_mutations":"T732A"}},"children":[{"name":"B.1.1.222","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.222"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.222"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.707209348678589}},"branch_attrs":{"mutations":{}}},{"name":"B.1.1.418","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.1.418"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.418"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["C1812T","A8072G","A10323G","A21194G","C22480T","G24197T","G24415T","G29751C"],"S":["A879S"],"nsp16":["D179G"],"nsp2":["A336V"],"nsp3":["N1785D"],"nsp5":["K90R"]},"labels":{"aa":"S: A879S; nsp16: D179G; nsp2: A336V; nsp3: N1785D; nsp5: K90R","spike_mutations":"A879S"}}}]}]},{"name":"internal_1fa9","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.250203609466553}},"branch_attrs":{"mutations":{"nuc":["G25088T"],"S":["V1176F"]},"labels":{"aa":"S: V1176F","spike_mutations":"V1176F"}},"children":[{"name":"B.1.1.28","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.250203609466553}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000626","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.622063636779785}},"branch_attrs":{"mutations":{"nuc":["C12053T","C28253T"],"nsp7":["L71F"]},"labels":{"aa":"nsp7: L71F"}},"children":[{"name":"P.2","node_attrs":{"div":17,"Nextclade_pango":{"value":"P.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":10},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.2"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.341432809829712}},"branch_attrs":{"mutations":{"nuc":["C100T","T10667G","C11824T","G23012A","G28628T","G28975T","C29754T"],"N":["A119S","M234I"],"S":["E484K"],"nsp5":["L205V"]},"labels":{"aa":"N: A119S, M234I; S: E484K; nsp5: L205V","spike_mutations":"E484K"}}},{"name":"P.6","node_attrs":{"div":23,"Nextclade_pango":{"value":"P.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":15},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.6"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C1077T","G2534T","C3736T","C7043T","C8980T","C10029T","A14113G","G21305A","G23587C","G23593T","C24382T","C25665T","G26172T"],"ORF3a":["M260I"],"S":["Q675H","Q677H"],"nsp12":["T225A"],"nsp16":["R216H"],"nsp2":["P91L","V577F"],"nsp3":["P1442S"],"nsp4":["T492I"]},"labels":{"aa":"ORF3a: M260I; S: Q675H, Q677H; nsp12: T225A; nsp16: R216H; nsp2: P91L, V577F; nsp3: P1442S; nsp4: T492I","spike_mutations":"Q675H, Q677H"}}}]},{"name":"NODE_0000627","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-6.379853248596191}},"branch_attrs":{"mutations":{"nuc":["C11450A","A28271C"],"nsp6":["Q160K"]},"labels":{"aa":"nsp6: Q160K"}},"children":[{"name":"P.4","node_attrs":{"div":28,"Nextclade_pango":{"value":"P.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.4"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A136G","G1811A","C3177T","C9693T","T9867C","C12008T","C12880T","A15932G","G18756T","C20436T","T22054G","C22079A","T22917G","C23673T","A23720G","G25540A","C28253T","C28932T"],"N":["A220V"],"ORF3a":["V50I"],"S":["N164K","Q173K","L452R","S704L","I720V"],"nsp12":["Y831C"],"nsp2":["A336T"],"nsp3":["P153L"],"nsp4":["A380V","L438P"],"nsp7":["L56F"]},"labels":{"aa":"N: A220V; ORF3a: V50I; S: N164K, Q173K, L452R, S704L, I720V; nsp12: Y831C; nsp2: A336T; nsp3: P153L; nsp4: A380V, L438P; nsp7: L56F","spike_mutations":"N164K, Q173K, L452R, S704L, I720V"}}},{"name":"P.5","node_attrs":{"div":27,"Nextclade_pango":{"value":"P.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-06-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28.5"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5175T","C8950T","C9891T","T10264C","C11152T","C13275T","T14103C","C14571T","T21568A","C21602A","C21721T","C21846T","G23012C","A23064C","C24904T","C28271T","C28531T","G28917T"],"N":["G215V"],"ORF9b":["T83I"],"S":["F2L","Q14K","T95I","E484Q","N501T"],"nsp10":["P84L"],"nsp3":["T819I"],"nsp4":["A446V"]},"labels":{"aa":"N: G215V; ORF9b: T83I; S: F2L, Q14K, T95I, E484Q, N501T; nsp10: P84L; nsp3: T819I; nsp4: A446V","spike_mutations":"F2L, Q14K, T95I, E484Q, N501T"}}}]},{"name":"NODE_0000628","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.28"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.28"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.552827835083008}},"branch_attrs":{"mutations":{"nuc":["G23012A","A23063T"],"S":["E484K","N501Y"]},"labels":{"aa":"S: E484K, N501Y","spike_mutations":"E484K, N501Y"}},"children":[{"name":"P.3","node_attrs":{"div":26,"Nextclade_pango":{"value":"P.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Theta"},"totalAminoacidSubstitutions":{"value":18},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21E (Theta)"},"partiallyAliased":{"value":"B.1.1.28.3"},"clade_nextstrain":{"value":"21E"},"clade_membership":{"value":"21E"},"placement_prior":{"value":-4.4443230628967285}},"branch_attrs":{"mutations":{"nuc":["A4926G","C7564A","T9867C","C11308A","C12049T","C12053T","C17074T","C17339T","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","A22356G","T23341C","C23604A","T24187A","G24836A","C24863T","A27897C","A28271-","C29724T"],"ORF8":["K2Q"],"S":["L141-","G142-","V143-","Y265C","P681H","E1092K","H1101Y"],"nsp13":["L280F","A368V"],"nsp3":["D736G"],"nsp4":["L438P"],"nsp6":["D112E"],"nsp7":["L71F"]},"labels":{"aa":"ORF8: K2Q; S: L141-, G142-, V143-, Y265C, P681H, E1092K, H1101Y; nsp13: L280F, A368V; nsp3: D736G; nsp4: L438P; nsp6: D112E; nsp7: L71F","clade":"Theta","spike_mutations":"L141-, G142-, V143-, Y265C, P681H, E1092K, H1101Y"}}},{"name":"NODE_0000629","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{"nuc":["T733C","C2749T","C3828T","A5648C","A6319G","A6613G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","C12778T","C13860T","G17259T","C21614T","C21621A","C21638T","G21974T","G22132T","A22812C","C23525T","C24642T","T26149C","G28167A","C28512G","A28877T","G28878C","T29834A"],"N":["P80R"],"ORF3a":["S253P"],"ORF8":["E92K"],"ORF9b":["Q77E"],"S":["L18F","T20N","P26S","D138Y","R190S","K417T","H655Y","T1027I"],"nsp13":["E341D"],"nsp3":["S370L","K977Q"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P80R; ORF3a: S253P; ORF8: E92K; ORF9b: Q77E; S: L18F, T20N, P26S, D138Y, R190S, K417T, H655Y, T1027I; nsp13: E341D; nsp3: S370L, K977Q; nsp6: S106-, G107-, F108-","clade":"Gamma","spike_mutations":"L18F, T20N, P26S, D138Y, R190S, K417T, H655Y, T1027I"}},"children":[{"name":"P.1","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-02-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{}}},{"name":"P.1.1","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.7353131771087646}},"branch_attrs":{"mutations":{"nuc":["T13851C"]}}},{"name":"P.1.11","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.11"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.509119987487793}},"branch_attrs":{"mutations":{"nuc":["C7945T","C23604G"],"S":["P681R"]},"labels":{"aa":"S: P681R","spike_mutations":"P681R"}}},{"name":"P.1.14","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.14"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.8808486461639404}},"branch_attrs":{"mutations":{"nuc":["A1G","G9105A","C23380T"],"nsp4":["S184N"]},"labels":{"aa":"nsp4: S184N"}}},{"name":"P.1.12.1","node_attrs":{"div":43,"Nextclade_pango":{"value":"P.1.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":28},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.12.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["T3592C","T14769G","G20925A","A22298G","C22413T","T23599A","C25613T","C25844T","T28251G","C28253T"],"ORF3a":["S74F","T151I"],"ORF8":["F120V"],"S":["R246G","T284I","N679K"]},"labels":{"aa":"ORF3a: S74F, T151I; ORF8: F120V; S: R246G, T284I, N679K","spike_mutations":"R246G, T284I, N679K"}}},{"name":"P.1.12","node_attrs":{"div":33,"Nextclade_pango":{"value":"P.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.12"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-2.802053213119507}},"branch_attrs":{"mutations":{}}},{"name":"P.1.16","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.16"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.7957029342651367}},"branch_attrs":{"mutations":{"nuc":["A25746G"],"ORF3a":["I118M"]},"labels":{"aa":"ORF3a: I118M"}}},{"name":"P.1.15","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.15"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.483485460281372}},"branch_attrs":{"mutations":{"nuc":["A2596G","C18129T"]}}},{"name":"P.1.4","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.4"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.011761665344238}},"branch_attrs":{"mutations":{"nuc":["T23599G"],"S":["N679K"]},"labels":{"aa":"S: N679K","spike_mutations":"N679K"}}},{"name":"P.1.6","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.6"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C10615T","C15714T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}},{"name":"P.1.7.1","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":24},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.7.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["T3049C","C10116T","C23604A"],"S":["P681H"],"nsp5":["T21I"]},"labels":{"aa":"S: P681H; nsp5: T21I","spike_mutations":"P681H"}}},{"name":"NODE_0000630","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.10"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.013175010681152}},"branch_attrs":{"mutations":{"nuc":["A1T","C1427T"],"nsp2":["H208Y"]},"labels":{"aa":"nsp2: H208Y"}},"children":[{"name":"P.1.10","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.013175010681152}},"branch_attrs":{"mutations":{}}},{"name":"P.1.10.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.10.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.112314701080322}},"branch_attrs":{"mutations":{"nuc":["C2841T","G4300T","C13329T","C26873T"],"nsp10":["T102I"],"nsp3":["A41V"]},"labels":{"aa":"nsp10: T102I; nsp3: A41V"}}}]},{"name":"NODE_0000631","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.17"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A1T","C346T","C28603T"]}},"children":[{"name":"P.1.17","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"P.1.17.1","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.17.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.076402187347412}},"branch_attrs":{"mutations":{"nuc":["A6704G","G19999T","C21707T"],"S":["H49Y"],"nsp15":["V127F"],"nsp3":["N1329D"]},"labels":{"aa":"S: H49Y; nsp15: V127F; nsp3: N1329D","spike_mutations":"H49Y"}}}]},{"name":"NODE_0000632","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["T592C","A4040G","C9891T"],"nsp3":["I441V"],"nsp4":["A446V"]},"labels":{"aa":"nsp3: I441V; nsp4: A446V"}},"children":[{"name":"P.1.9","node_attrs":{"div":39,"Nextclade_pango":{"value":"P.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":26},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.9"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C6040T","C18647T","G23587C"],"S":["Q675H"],"nsp14":["P203L"]},"labels":{"aa":"S: Q675H; nsp14: P203L","spike_mutations":"Q675H"}}},{"name":"P.1.8","node_attrs":{"div":42,"Nextclade_pango":{"value":"P.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.8"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A20055G","C22971A","C23604G","G25266T","C26039T","G27915T"],"ORF3a":["S216L"],"ORF8":["G8*"],"S":["T470N","P681R","C1235F"]},"labels":{"aa":"ORF3a: S216L; ORF8: G8*; S: T470N, P681R, C1235F","spike_mutations":"T470N, P681R, C1235F"}}}]},{"name":"NODE_0000633","node_attrs":{"div":34,"Nextclade_pango":{"value":"P.1"},"clade_who":{"value":"Gamma"},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.685761451721191}},"branch_attrs":{"mutations":{"nuc":["C1912T"]}},"children":[{"name":"P.1.13","node_attrs":{"div":35,"Nextclade_pango":{"value":"P.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.13"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.1822357177734375}},"branch_attrs":{"mutations":{"nuc":["G10610T"],"nsp5":["V186F"]},"labels":{"aa":"nsp5: V186F"}}},{"name":"P.1.2","node_attrs":{"div":38,"Nextclade_pango":{"value":"P.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.2"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-4.205961227416992}},"branch_attrs":{"mutations":{"nuc":["A2550G","C5724T","G25855T","C28789T"],"ORF3a":["D155Y"],"nsp2":["D582G"],"nsp3":["T1002I"]},"labels":{"aa":"ORF3a: D155Y; nsp2: D582G; nsp3: T1002I"}}},{"name":"P.1.7","node_attrs":{"div":36,"Nextclade_pango":{"value":"P.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Gamma"},"totalAminoacidSubstitutions":{"value":23},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20J (Gamma)"},"partiallyAliased":{"value":"B.1.1.28.1.7"},"clade_nextstrain":{"value":"20J"},"clade_membership":{"value":"20J"},"placement_prior":{"value":-3.55728816986084}},"branch_attrs":{"mutations":{"nuc":["C16293T","C23604A"],"S":["P681H"]},"labels":{"aa":"S: P681H","spike_mutations":"P681H"}}}]}]}]}]},{"name":"NODE_0000634","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.009088039398193}},"branch_attrs":{"mutations":{"nuc":["C23731T"]}},"children":[{"name":"B.1.1.375","node_attrs":{"div":17,"Nextclade_pango":{"value":"B.1.1.375"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.375"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.222192764282227}},"branch_attrs":{"mutations":{"nuc":["C2509T","C6781T","C13536T","G17027T","C18747T","G22992A","A23233G","G28048A","G29425T"],"N":["Q384H"],"ORF8":["R52K"],"S":["S477N"],"nsp13":["S264I"]},"labels":{"aa":"N: Q384H; ORF8: R52K; S: S477N; nsp13: S264I","spike_mutations":"S477N"}}},{"name":"NODE_0000635","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.315249443054199}},"branch_attrs":{"mutations":{"nuc":["G10097A"],"nsp5":["G15S"]},"labels":{"aa":"nsp5: G15S"}},"children":[{"name":"B.1.1.369","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1.369"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.369"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.7882320880889893}},"branch_attrs":{"mutations":{"nuc":["G28580T"],"N":["D103Y"]},"labels":{"aa":"N: D103Y"}}},{"name":"B.1.1.372","node_attrs":{"div":9,"Nextclade_pango":{"value":"B.1.1.372"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":5},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.372"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.315249443054199}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000636","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-3.7465412616729736}},"branch_attrs":{"mutations":{"nuc":["A1G","C4002T","C13536T"],"nsp3":["T428I"]},"labels":{"aa":"nsp3: T428I","clade":"20D"}},"children":[{"name":"B.1.1.1","node_attrs":{"div":12,"Nextclade_pango":{"value":"B.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-3.7465412616729736}},"branch_attrs":{"mutations":{}}},{"name":"C.11","node_attrs":{"div":16,"Nextclade_pango":{"value":"C.11"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.11"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.6986403465271}},"branch_attrs":{"mutations":{"nuc":["T3G","T8071C","G13201A","C27804T"]}}},{"name":"C.14","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.14"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.14"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.6111273765563965}},"branch_attrs":{"mutations":{"nuc":["G29179T"]}}},{"name":"C.13","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.13"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.13"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.601932048797607}},"branch_attrs":{"mutations":{"nuc":["A21131G"],"nsp16":["Q158R"]},"labels":{"aa":"nsp16: Q158R"}}},{"name":"C.23","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.23"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.903609752655029}},"branch_attrs":{"mutations":{"nuc":["C15240T"]}}},{"name":"C.26","node_attrs":{"div":15,"Nextclade_pango":{"value":"C.26"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.26"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.097338676452637}},"branch_attrs":{"mutations":{"nuc":["G1T","T8278C","G12661A","A29852-","G29853-","C29854-","T29855-","T29856-","C29857-","T29858-","T29859-","A29860-","G29861-","G29862-","A29863-","G29864-","A29865-","A29866-","T29867-","G29868-","A29869-","C29870-","A29871-","A29872-","A29873-"]}}},{"name":"C.33","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.33"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.33"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.331241130828857}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}}},{"name":"C.35","node_attrs":{"div":15,"Nextclade_pango":{"value":"C.35"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.35"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.0756001472473145}},"branch_attrs":{"mutations":{"nuc":["G1T","G5950T","G19732T"],"nsp15":["V38F"],"nsp3":["K1077N"]},"labels":{"aa":"nsp15: V38F; nsp3: K1077N"}}},{"name":"C.29","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.29"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.29"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.694921016693115}},"branch_attrs":{"mutations":{"nuc":["T27900C"],"ORF8":["F3L"]},"labels":{"aa":"ORF8: F3L"}}},{"name":"C.32","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.32"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":6},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.32"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.398115634918213}},"branch_attrs":{"mutations":{"nuc":["C14877T"]}}},{"name":"C.4","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.4"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.4"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["A4G","G24794T"],"S":["A1078S"]},"labels":{"aa":"S: A1078S","spike_mutations":"A1078S"}}},{"name":"C.38","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.38"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":22},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.38"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A4307C","C4763T","C5812T","G6609T","A9103C","C9286T","A11201G","G11417T","C19862T","C21057T","C21727T","T21752A","G23012A","G23948T","T26112C","T26767C","C27925A","C28311T","C28905T","G29405C"],"M":["I82T"],"N":["P13L","A211V","E378Q"],"ORF8":["T11K"],"ORF9b":["P10S"],"S":["W64R","E484K","D796Y"],"nsp15":["A81V"],"nsp3":["K530Q","H682Y","R1297I"],"nsp4":["E183D"],"nsp6":["T77A","V149F"]},"labels":{"aa":"M: I82T; N: P13L, A211V, E378Q; ORF8: T11K; ORF9b: P10S; S: W64R, E484K, D796Y; nsp15: A81V; nsp3: K530Q, H682Y, R1297I; nsp4: E183D; nsp6: T77A, V149F","spike_mutations":"W64R, E484K, D796Y"}}},{"name":"NODE_0000637","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.791935920715332}},"branch_attrs":{"mutations":{"nuc":["C18747T","G29425T"],"N":["Q384H"]},"labels":{"aa":"N: Q384H"}},"children":[{"name":"C.1.2","node_attrs":{"div":30,"Nextclade_pango":{"value":"C.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":5},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.486576557159424}},"branch_attrs":{"mutations":{"nuc":["G569A","C2485T","C5175T","A7699G","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21969T","G22132T","A22206G","C22210T","G22289-","C22290-","T22291-","T22907C","G23012A","A23063T","C23525T","T23599A","C23709T","G26155-","T26156-","T26157-","C28311T","T28516C"],"N":["P13L"],"ORF3a":["V255-"],"ORF9b":["P10S","M78T"],"S":["C136F","R190S","D215G","A243-","Y449H","E484K","N501Y","H655Y","N679K","T716I"],"nsp1":["E102K"],"nsp3":["T819I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P13L; ORF3a: V255-; ORF9b: P10S, M78T; S: C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I; nsp1: E102K; nsp3: T819I; nsp6: S106-, G107-, F108-","spike_mutations":"C136F, R190S, D215G, A243-, Y449H, E484K, N501Y, H655Y, N679K, T716I"}}},{"name":"C.1","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.1"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.791935920715332}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000638","node_attrs":{"div":13,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.4457597732543945}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"C.16","node_attrs":{"div":16,"Nextclade_pango":{"value":"C.16"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":9},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.16"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.295919418334961}},"branch_attrs":{"mutations":{"nuc":["G3302A","C9693T","G29422T"],"nsp3":["E195K"],"nsp4":["A380V"]},"labels":{"aa":"nsp3: E195K; nsp4: A380V"}}},{"name":"C.40","node_attrs":{"div":23,"Nextclade_pango":{"value":"C.40"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":16},"totalAminoacidDeletions":{"value":3},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"S:245-246,ORF3a:258-276"},"designation_date":{"value":"2021-08-27"},"qc.frameShifts.frameShifts":{"value":"S:245-246"},"qc.frameShifts.totalFrameShifts":{"value":1},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.40"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C2094T","A3069G","C9891T","A10982G","A12820G","C16466T","G22205C","T22292-","G22299-","A22300-","A22301-","G22302-","T22303-","C23481T","C24138A","A26161-","A28271-","G28917T"],"N":["G215V"],"ORF3a":["N257-"],"S":["D215H","L244-","S247-","S640F","T859N"],"nsp13":["P77L"],"nsp2":["S430L"],"nsp3":["D117G"],"nsp4":["A446V"],"nsp6":["K4E"]},"labels":{"aa":"N: G215V; ORF3a: N257-; S: D215H, L244-, S247-, S640F, T859N; nsp13: P77L; nsp2: S430L; nsp3: D117G; nsp4: A446V; nsp6: K4E","spike_mutations":"D215H, L244-, S247-, S640F, T859N"}}}]},{"name":"NODE_0000639","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.2"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.998661518096924}},"branch_attrs":{"mutations":{"nuc":["T14345C","G18292T"],"nsp12":["L302S"],"nsp14":["A85S"]},"labels":{"aa":"nsp12: L302S; nsp14: A85S"}},"children":[{"name":"C.2.1","node_attrs":{"div":22,"Nextclade_pango":{"value":"C.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":12},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.745296478271484}},"branch_attrs":{"mutations":{"nuc":["G922T","T8323C","T15437C","C18501T","A23064C","C25624T","C28453T","C29642T"],"ORF10":["Q29*"],"ORF3a":["H78Y"],"ORF9b":["A57V"],"S":["N501T"],"nsp12":["M666T"]},"labels":{"aa":"ORF10: Q29*; ORF3a: H78Y; ORF9b: A57V; S: N501T; nsp12: M666T","spike_mutations":"N501T"}}},{"name":"C.2","node_attrs":{"div":14,"Nextclade_pango":{"value":"C.2"},"qc.stopCodons.totalStopCodons":{"value":0},"totalAminoacidSubstitutions":{"value":8},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.2"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.998661518096924}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_9cca","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.36"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.5506086349487305}},"branch_attrs":{"mutations":{"nuc":["G28908T"],"N":["G212V"]},"labels":{"aa":"N: G212V"}},"children":[{"name":"C.36","node_attrs":{"div":13,"Nextclade_pango":{"value":"C.36"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":7},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.5506086349487305}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000641","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.36.3"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["G569A","C2841T","G5180A","C7124T","G9203A","G9929A","C11325T","T11337C","C12534T","G16549T","C17766T","C21597T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22016A","A22600C","T22917G","G23593T","G24257T","T26767C","G27882T","A28271-"],"M":["I82T"],"ORF7b":["A43S"],"S":["S12F","H69-","V70-","W152R","R346S","L452R","Q677H","A899S"],"nsp1":["E102K"],"nsp13":["D105Y"],"nsp3":["A41V","D821N","P1469S"],"nsp4":["D217N","D459N"],"nsp6":["S118L","L122S"],"nsp8":["T148I"]},"labels":{"aa":"M: I82T; ORF7b: A43S; S: S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S; nsp1: E102K; nsp13: D105Y; nsp3: A41V, D821N, P1469S; nsp4: D217N, D459N; nsp6: S118L, L122S; nsp8: T148I","spike_mutations":"S12F, H69-, V70-, W152R, R346S, L452R, Q677H, A899S"}},"children":[{"name":"C.36.3.1","node_attrs":{"div":40,"Nextclade_pango":{"value":"C.36.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":29},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["C6706T","C17822T","C18189T","G22992A","T24811C","T25729C","A29040G","C29632T"],"N":["K256R"],"ORF3a":["Y113H"],"S":["S477N"],"nsp13":["P529L"]},"labels":{"aa":"N: K256R; ORF3a: Y113H; S: S477N; nsp13: P529L","spike_mutations":"S477N"}}},{"name":"C.36.3","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.36.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":25},"totalAminoacidDeletions":{"value":2},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-05-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.36.3"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000642","node_attrs":{"div":15,"Nextclade_pango":{"value":"B.1.1.1"},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T9867C","T22917A","C28253T","A28271C"],"S":["L452Q"],"nsp4":["L438P"]},"labels":{"aa":"S: L452Q; nsp4: L438P","spike_mutations":"L452Q"}},"children":[{"name":"C.39","node_attrs":{"div":31,"Nextclade_pango":{"value":"C.39"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20D"},"partiallyAliased":{"value":"B.1.1.1.39"},"clade_nextstrain":{"value":"20D"},"clade_membership":{"value":"20D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2110T","C4763T","C6726T","C7113T","T7348G","C11345T","C14585T","C15194A","C21588T","G22131A","C22997T","T26038C","C26366T","C27128T","A28742G"],"E":["A41V"],"N":["I157V"],"ORF3a":["S216P"],"S":["P9L","R190K","P479S"],"nsp12":["A382V","A585D"],"nsp3":["H682Y","T1336I","T1465I","N1543K"],"nsp6":["L125F"]},"labels":{"aa":"E: A41V; N: I157V; ORF3a: S216P; S: P9L, R190K, P479S; nsp12: A382V, A585D; nsp3: H682Y, T1336I, T1465I, N1543K; nsp6: L125F","spike_mutations":"P9L, R190K, P479S"}}},{"name":"NODE_0000643","node_attrs":{"div":28,"Nextclade_pango":{"value":"C.37"},"clade_who":{"value":"Lambda"},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{"nuc":["C7124T","T7424G","C9857T","C10029T","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","T11294-","T11295-","T11296-","G21786T","C21789T","G22299-","A22300-","A22301-","G22302-","T22303-","T22304-","A22305-","T22306-","T22307-","T22308-","G22309-","A22310-","C22311-","T22312-","C22313-","C22314-","T22315-","G22316-","G22317-","T22318-","G22319-","T23031C","C24138A","C26894T","C28271T","C28311T","G28913T","C29311T"],"N":["P13L","G214C"],"ORF9b":["P10S"],"S":["G75V","T76I","R246-","S247-","Y248-","L249-","T250-","P251-","G252-","D253N","F490S","T859N"],"nsp3":["P1469S","F1569V"],"nsp4":["T492I"],"nsp6":["S106-","G107-","F108-"]},"labels":{"aa":"N: P13L, G214C; ORF9b: P10S; S: G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N; nsp3: P1469S, F1569V; nsp4: T492I; nsp6: S106-, G107-, F108-","clade":"Lambda","spike_mutations":"G75V, T76I, R246-, S247-, Y248-, L249-, T250-, P251-, G252-, D253N, F490S, T859N"}},"children":[{"name":"C.37","node_attrs":{"div":28,"Nextclade_pango":{"value":"C.37"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Lambda"},"totalAminoacidSubstitutions":{"value":19},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-3.5540406703948975}},"branch_attrs":{"mutations":{}}},{"name":"C.37.1","node_attrs":{"div":32,"Nextclade_pango":{"value":"C.37.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Lambda"},"totalAminoacidSubstitutions":{"value":20},"totalAminoacidDeletions":{"value":10},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-07-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21G (Lambda)"},"partiallyAliased":{"value":"B.1.1.1.37.1"},"clade_nextstrain":{"value":"21G"},"clade_membership":{"value":"21G"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C20806T","T25760C","A28877T","G28878C"],"ORF3a":["I123T"]},"labels":{"aa":"ORF3a: I123T"}}}]}]}]}]}]},{"name":"NODE_0000644","node_attrs":{"div":8,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-4.207627296447754}},"branch_attrs":{"mutations":{"nuc":["C10029T"],"nsp4":["T492I"]},"labels":{"aa":"nsp4: T492I"}},"children":[{"name":"AT.1","node_attrs":{"div":32,"Nextclade_pango":{"value":"AT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":21},"totalAminoacidDeletions":{"value":9},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.370.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C1392T","G3281T","A3542G","A5176G","C7005A","T9070C","C9778T","A11451G","T12620A","C16985A","G17562T","G19180T","C20759T","C21588T","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","A22206G","A22296C","G23012A","G23900A","C24370T","T25675A","G26211T","C26568A","G28079T","A28271G"],"M":["L16I"],"ORF3a":["L95M"],"S":["P9L","C136-","N137-","D138-","P139-","F140-","L141-","G142-","V143-","Y144-","D215G","H245P","E484K","E780K"],"nsp13":["T250N"],"nsp14":["V381L"],"nsp16":["A34V"],"nsp2":["S196L"],"nsp3":["V188F","T275A","T1429N"],"nsp6":["Q160R"],"nsp8":["S177T"]},"labels":{"aa":"M: L16I; ORF3a: L95M; S: P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K; nsp13: T250N; nsp14: V381L; nsp16: A34V; nsp2: S196L; nsp3: V188F, T275A, T1429N; nsp6: Q160R; nsp8: S177T","spike_mutations":"P9L, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, D215G, H245P, E484K, E780K"}}},{"name":"NODE_0000645","node_attrs":{"div":10,"Nextclade_pango":{"value":"B.1.1"},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-3.820734977722168}},"branch_attrs":{"mutations":{"nuc":["C22995A","C23604A"],"S":["T478K","P681H"]},"labels":{"aa":"S: T478K, P681H","spike_mutations":"T478K, P681H"}},"children":[{"name":"B.1.1.519","node_attrs":{"div":20,"Nextclade_pango":{"value":"B.1.1.519"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"totalAminoacidSubstitutions":{"value":11},"totalAminoacidDeletions":{"value":0},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-03-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"20B"},"partiallyAliased":{"value":"B.1.1.519"},"clade_nextstrain":{"value":"20B"},"clade_membership":{"value":"20B"},"placement_prior":{"value":-2.7774267196655273}},"branch_attrs":{"mutations":{"nuc":["C203T","C222T","C3140T","C10954T","A11117G","C12789T","T19839C","C21306T","A23756G","C29197T"],"S":["T732A"],"nsp3":["P141S"],"nsp6":["I49V"],"nsp9":["T35I"]},"labels":{"aa":"S: T732A; nsp3: P141S; nsp6: I49V; nsp9: T35I","spike_mutations":"T732A"}}},{"name":"21M","node_attrs":{"div":40,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-3.696544885635376}},"branch_attrs":{"mutations":{"nuc":["C10449A","T11288-","C11289-","T11290-","G11291-","G11292-","T11293-","A18163G","C21762T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21846T","G21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A22194-","T22195-","T22196-","G22578A","C22674T","T22679C","C22686T","G22813T","T22882G","G22898A","G22992A","A23013C","A23040G","A23055G","A23063T","T23075C","C23525T","T23599G","C23854A","G23948T","A24424T","T24469A","C26270T","C26577G","G26709A","A27259C","C27807T","A28271T","C28311T","G28362-","A28363-","G28364-","A28365-","A28366-","C28367-","G28368-","C28369-","A28370-"],"E":["T9I"],"M":["Q19E","A63T"],"N":["P13L","E31-","R32-","S33-"],"ORF9b":["P10S","E27-","N28-","A29-"],"S":["A67V","H69-","V70-","T95I","G142-","V143-","Y144-","Y145D","N211-","L212I","G339D","S371F","S373P","S375F","K417N","N440K","G446S","S477N","E484A","Q493R","Q498R","N501Y","Y505H","H655Y","N679K","N764K","D796Y","Q954H","N969K"],"nsp14":["I42V"],"nsp5":["P132H"],"nsp6":["S106-","G107-"]},"labels":{"aa":"E: T9I; M: Q19E, A63T; N: P13L, E31-, R32-, S33-; ORF9b: P10S, E27-, N28-, A29-; S: A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K; nsp14: I42V; nsp5: P132H; nsp6: S106-, G107-","clade":"Omicron","spike_mutations":"A67V, H69-, V70-, T95I, G142-, V143-, Y144-, Y145D, N211-, L212I, G339D, S371F, S373P, S375F, K417N, N440K, G446S, S477N, E484A, Q493R, Q498R, N501Y, Y505H, H655Y, N679K, N764K, D796Y, Q954H, N969K"}},"children":[{"name":"NODE_0000647","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.9919705390930176}},"branch_attrs":{"mutations":{"nuc":["A2832G","T5386G","G6513-","T6514-","T6515-","G8393A","T11285-","T11286-","G11287-","A11537G","T13195C","C15240T","T22673C","G23048A","C23202A","C24130A","C24503T","C25000T","C25584T","A26530G"],"M":["D3G"],"S":["F371L","G496S","T547K","N856K","L981F"],"nsp3":["K38R","S1265-","L1266I","A1892T"],"nsp6":["L105-","I189V"]},"labels":{"aa":"M: D3G; S: F371L, G496S, T547K, N856K, L981F; nsp3: K38R, S1265-, L1266I, A1892T; nsp6: L105-, I189V","clade":"21K","spike_mutations":"F371L, G496S, T547K, N856K, L981F"}},"children":[{"name":"BA.1","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":46},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.9919705390930176}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.12","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.12"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7732186317443848}},"branch_attrs":{"mutations":{"nuc":["A5T","G22487C","C28315T"],"ORF9b":["A11V"],"S":["E309Q"]},"labels":{"aa":"ORF9b: A11V; S: E309Q","spike_mutations":"E309Q"}}},{"name":"BA.1.10","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.10"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.681899070739746}},"branch_attrs":{"mutations":{"nuc":["C21T","A17042G"],"nsp13":["Y269C"]},"labels":{"aa":"nsp13: Y269C"}}},{"name":"BA.1.18","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.18"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.3796184062957764}},"branch_attrs":{"mutations":{"nuc":["C5730T"],"nsp3":["T1004I"]},"labels":{"aa":"nsp3: T1004I"}}},{"name":"BA.1.2","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.660147190093994}},"branch_attrs":{"mutations":{"nuc":["C7420T","C11669T"],"nsp6":["R233C"]},"labels":{"aa":"nsp6: R233C"}}},{"name":"BA.1.19","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.19"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.5513505935668945}},"branch_attrs":{"mutations":{"nuc":["A1G","C21034T"],"nsp16":["L126F"]},"labels":{"aa":"nsp16: L126F"}}},{"name":"BA.1.20","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.20"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.5852789878845215}},"branch_attrs":{"mutations":{"nuc":["C11950T","C28472T"],"N":["P67S"]},"labels":{"aa":"N: P67S"}}},{"name":"BA.1.22","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.22"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.7762668132781982}},"branch_attrs":{"mutations":{"nuc":["C21T","G3182A","G5515T"],"nsp3":["E155K"]},"labels":{"aa":"nsp3: E155K"}}},{"name":"BA.1.24","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.24"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.808385372161865}},"branch_attrs":{"mutations":{"nuc":["G22580A","G28378T"],"ORF9b":["R32L"],"S":["E340K"]},"labels":{"aa":"ORF9b: R32L; S: E340K","spike_mutations":"E340K"}}},{"name":"BA.1.3","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.336390972137451}},"branch_attrs":{"mutations":{"nuc":["C21T","A3481G","C8645T"],"nsp4":["H31Y"]},"labels":{"aa":"nsp4: H31Y"}}},{"name":"BA.1.23","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.23"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.952954292297363}},"branch_attrs":{"mutations":{"nuc":["G22599C","T22926G","A22935T","C23013T","C23625T"],"S":["R346T","L455W","K458M","A484V","A688V"]},"labels":{"aa":"S: R346T, L455W, K458M, A484V, A688V","spike_mutations":"R346T, L455W, K458M, A484V, A688V"}}},{"name":"BA.1.4","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.4"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.1539411544799805}},"branch_attrs":{"mutations":{"nuc":["C21T","G23351A"],"S":["V597I"]},"labels":{"aa":"S: V597I","spike_mutations":"V597I"}}},{"name":"BA.1.6","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.6"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.269890308380127}},"branch_attrs":{"mutations":{"nuc":["C21T","C17639T"],"nsp13":["S468L"]},"labels":{"aa":"nsp13: S468L"}}},{"name":"BA.1.5","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.5"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.170540809631348}},"branch_attrs":{"mutations":{"nuc":["C21T","C2091T","C24054T"],"S":["A831V"],"nsp2":["T429I"]},"labels":{"aa":"S: A831V; nsp2: T429I","spike_mutations":"A831V"}}},{"name":"BA.1.8","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.8"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.060263156890869}},"branch_attrs":{"mutations":{"nuc":["A1G","C11455T","C23987T","C29666T"],"ORF10":["L37F"],"S":["P809S"]},"labels":{"aa":"ORF10: L37F; S: P809S","spike_mutations":"P809S"}}},{"name":"BA.1.7","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.7"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.598390579223633}},"branch_attrs":{"mutations":{"nuc":["C21T","C27686T"],"ORF7a":["S98F"]},"labels":{"aa":"ORF7a: S98F"}}},{"name":"BA.1.9","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.9"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.149862766265869}},"branch_attrs":{"mutations":{"nuc":["A1C","C21T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"NODE_0000648","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{"nuc":["G1957T"],"nsp2":["K384N"]},"labels":{"aa":"nsp2: K384N"}},"children":[{"name":"BA.1.13.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.6200740337371826}},"branch_attrs":{"mutations":{"nuc":["A3779G","G19684T"],"nsp15":["V22L"],"nsp3":["N354D"]},"labels":{"aa":"nsp15: V22L; nsp3: N354D"}}},{"name":"BA.1.13","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7240750789642334}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000649","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.447277069091797}},"branch_attrs":{"mutations":{"nuc":["G27762T"],"ORF7b":["E3*"]},"labels":{"aa":"ORF7b: E3*"}},"children":[{"name":"BA.1.21","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.447277069091797}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.21.1","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.21.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.21.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.046947002410889}},"branch_attrs":{"mutations":{"nuc":["T15685A"],"nsp12":["L749M"]},"labels":{"aa":"nsp12: L749M"}}}]},{"name":"NODE_0000650","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{"nuc":["A1C","C12786T"],"nsp9":["T34I"]},"labels":{"aa":"nsp9: T34I"}},"children":[{"name":"BA.1.14","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.397987127304077}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.14.2","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.14.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.215561866760254}},"branch_attrs":{"mutations":{"nuc":["C1812T"],"nsp2":["A336V"]},"labels":{"aa":"nsp2: A336V"}}},{"name":"BA.1.14.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.14.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.468590497970581}},"branch_attrs":{"mutations":{"nuc":["C11109T"],"nsp6":["A46V"]},"labels":{"aa":"nsp6: A46V"}}}]},{"name":"NODE_0000651","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{"nuc":["T3104C","C29632T"],"nsp3":["Y129H"]},"labels":{"aa":"nsp3: Y129H"}},"children":[{"name":"BA.1.16.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.663555145263672}},"branch_attrs":{"mutations":{"nuc":["G9758A","G25455A","T25556G"],"ORF3a":["V55G"],"nsp4":["V402I"]},"labels":{"aa":"ORF3a: V55G; nsp4: V402I"}}},{"name":"BA.1.16","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.581878662109375}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.16.2","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.16.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-5.067102432250977}},"branch_attrs":{"mutations":{"nuc":["C21T","T12436C","A28254G"],"ORF8":["I121V"]},"labels":{"aa":"ORF8: I121V"}}}]},{"name":"NODE_0000652","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{"nuc":["A1C","T10135C","C25708T","A29301G"],"N":["D343G"],"ORF3a":["L106F"]},"labels":{"aa":"N: D343G; ORF3a: L106F"}},"children":[{"name":"BA.1.15","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.236675262451172}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.15.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.538003921508789}},"branch_attrs":{"mutations":{"nuc":["A24803G"],"S":["I1081V"]},"labels":{"aa":"S: I1081V","spike_mutations":"I1081V"}}},{"name":"BA.1.15.2","node_attrs":{"div":60,"Nextclade_pango":{"value":"BA.1.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.754347085952759}},"branch_attrs":{"mutations":{"nuc":["G22520A","C23444A"],"S":["V320I","Q628K"]},"labels":{"aa":"S: V320I, Q628K","spike_mutations":"V320I, Q628K"}}},{"name":"BA.1.15.3","node_attrs":{"div":61,"Nextclade_pango":{"value":"BA.1.15.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.15.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.253582000732422}},"branch_attrs":{"mutations":{"nuc":["C21T","C3602T","C25886T"],"ORF3a":["S165F"],"nsp3":["H295Y"]},"labels":{"aa":"ORF3a: S165F; nsp3: H295Y"}}}]},{"name":"NODE_0000653","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.17"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{"nuc":["A1C","G5924A"],"nsp3":["V1069I"]},"labels":{"aa":"nsp3: V1069I"}},"children":[{"name":"BA.1.17","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.573190927505493}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.17.1","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.100675106048584}},"branch_attrs":{"mutations":{"nuc":["C21T","C4683T"],"nsp3":["A655V"]},"labels":{"aa":"nsp3: A655V"}}},{"name":"NODE_0000654","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.335338830947876}},"branch_attrs":{"mutations":{"nuc":["C1G","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}},"children":[{"name":"BA.1.17.2","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.17.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.335338830947876}},"branch_attrs":{"mutations":{}}},{"name":"BD.1","node_attrs":{"div":61,"Nextclade_pango":{"value":"BD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.17.2.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4503445625305176}},"branch_attrs":{"mutations":{"nuc":["C21T","C3241T","C23444A"],"S":["Q628K"]},"labels":{"aa":"S: Q628K","spike_mutations":"Q628K"}}}]}]},{"name":"NODE_0000655","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4240970611572266}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}},"children":[{"name":"BA.1.1","node_attrs":{"div":55,"Nextclade_pango":{"value":"BA.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":47},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.4240970611572266}},"branch_attrs":{"mutations":{}}},{"name":"BA.1.1.3","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.3"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.618063926696777}},"branch_attrs":{"mutations":{"nuc":["C4582T","C23934T","A28416G"],"N":["N48S"],"ORF9b":["I45V"],"S":["T791I"]},"labels":{"aa":"N: N48S; ORF9b: I45V; S: T791I","spike_mutations":"T791I"}}},{"name":"BA.1.1.4","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.4"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.7377076148986816}},"branch_attrs":{"mutations":{"nuc":["C21T","G16744A","T25711C","C29754T"],"ORF3a":["Y107H"],"nsp13":["G170S"]},"labels":{"aa":"ORF3a: Y107H; nsp13: G170S"}}},{"name":"NODE_0000656","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.674670934677124}},"branch_attrs":{"mutations":{"nuc":["A1T","A16064G"],"nsp12":["Q875R"]},"labels":{"aa":"nsp12: Q875R"}},"children":[{"name":"BA.1.1.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.674670934677124}},"branch_attrs":{"mutations":{}}},{"name":"BC.1","node_attrs":{"div":59,"Nextclade_pango":{"value":"BC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.36091685295105}},"branch_attrs":{"mutations":{"nuc":["C5833T","A22259G"],"S":["I233V"]},"labels":{"aa":"S: I233V","spike_mutations":"I233V"}}},{"name":"BC.2","node_attrs":{"div":60,"Nextclade_pango":{"value":"BC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.884258270263672}},"branch_attrs":{"mutations":{"nuc":["C21T","C13862T","G19348A"],"nsp12":["T141I"],"nsp14":["V437I"]},"labels":{"aa":"nsp12: T141I; nsp14: V437I"}}}]},{"name":"NODE_0000657","node_attrs":{"div":56,"Nextclade_pango":{"value":"BA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.3621491193771362}},"branch_attrs":{"mutations":{"nuc":["C2470T"]}},"children":[{"name":"BA.1.1.10","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.10"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.4704771041870117}},"branch_attrs":{"mutations":{"nuc":["C21T","C12513T"],"nsp8":["T141M"]},"labels":{"aa":"nsp8: T141M"}}},{"name":"BA.1.1.11","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.11"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.2315807342529297}},"branch_attrs":{"mutations":{"nuc":["G2354A"],"nsp2":["G517R"]},"labels":{"aa":"nsp2: G517R"}}},{"name":"BA.1.1.12","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.12"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.3868720531463623}},"branch_attrs":{"mutations":{"nuc":["C21T","C2942A"],"nsp3":["L75M"]},"labels":{"aa":"nsp3: L75M"}}},{"name":"BA.1.1.14","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.14"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.8932130336761475}},"branch_attrs":{"mutations":{"nuc":["A14107G"],"nsp12":["I223V"]},"labels":{"aa":"nsp12: I223V"}}},{"name":"BA.1.1.13","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.13"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.139564037322998}},"branch_attrs":{"mutations":{"nuc":["C21T","C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"BA.1.1.16","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.16"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-1.8349038362503052}},"branch_attrs":{"mutations":{"nuc":["A1C","C21595T","C27509G"],"ORF7a":["T39R"]},"labels":{"aa":"ORF7a: T39R"}}},{"name":"BA.1.1.15","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.15"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.933518171310425}},"branch_attrs":{"mutations":{"nuc":["G13570A","G29755C"],"nsp12":["G44S"]},"labels":{"aa":"nsp12: G44S"}}},{"name":"BA.1.1.18","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.18"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.329127311706543}},"branch_attrs":{"mutations":{"nuc":["C7926T"],"nsp3":["A1736V"]},"labels":{"aa":"nsp3: A1736V"}}},{"name":"BA.1.1.17","node_attrs":{"div":58,"Nextclade_pango":{"value":"BA.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.17"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.2085862159729}},"branch_attrs":{"mutations":{"nuc":["G1659T","C5183T"],"nsp2":["G285V"],"nsp3":["P822S"]},"labels":{"aa":"nsp2: G285V; nsp3: P822S"}}},{"name":"BA.1.1.2","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.2"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-2.413982391357422}},"branch_attrs":{"mutations":{"nuc":["C10560G"],"nsp5":["T169S"]},"labels":{"aa":"nsp5: T169S"}}},{"name":"BA.1.1.5","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.5"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.915313482284546}},"branch_attrs":{"mutations":{"nuc":["C21T","A2589G","C26996T"],"nsp2":["E595G"]},"labels":{"aa":"nsp2: E595G"}}},{"name":"BA.1.1.9","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.9"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.4199085235595703}},"branch_attrs":{"mutations":{"nuc":["C13421T"],"nsp10":["L133F"]},"labels":{"aa":"nsp10: L133F"}}},{"name":"BA.1.1.6","node_attrs":{"div":59,"Nextclade_pango":{"value":"BA.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.6"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-4.071193695068359}},"branch_attrs":{"mutations":{"nuc":["C21T","C5144T","C28757T"],"N":["P162S"]},"labels":{"aa":"N: P162S"}}},{"name":"BA.1.1.7","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.7"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.486417770385742}},"branch_attrs":{"mutations":{"nuc":["C2453T"],"nsp2":["L550F"]},"labels":{"aa":"nsp2: L550F"}}},{"name":"BA.1.1.8","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":48},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21K (BA.1)"},"partiallyAliased":{"value":"BA.1.1.8"},"clade_nextstrain":{"value":"21K"},"clade_membership":{"value":"21K"},"placement_prior":{"value":-3.9190704822540283}},"branch_attrs":{"mutations":{"nuc":["C1766A"],"nsp2":["Q321K"]},"labels":{"aa":"nsp2: Q321K"}}}]}]}]},{"name":"internal_a01b","node_attrs":{"div":51,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.760036468505859}},"branch_attrs":{"mutations":{"nuc":["T670G","G4184A","C4321T","C9534T","G10447A","T11294-","T11295-","T11296-","C12880T","C15714T","G22775A","C26060T","C26858T","A29510C","C29741-","G29742-","C29743-","G29744-","G29745-","A29746-","G29747-","T29748-","A29749-","C29750-","G29751-","A29752-","T29753-","C29754-","G29755-","A29756-","G29757-","T29758-","G29759-"],"N":["S413R"],"ORF3a":["T223I"],"S":["D405N"],"nsp1":["S135R"],"nsp3":["G489S"],"nsp4":["T327I"],"nsp6":["F108-"]},"labels":{"aa":"N: S413R; ORF3a: T223I; S: D405N; nsp1: S135R; nsp3: G489S; nsp4: T327I; nsp6: F108-","spike_mutations":"D405N"}},"children":[{"name":"internal_8b65","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C832T","C11235T","C29311T"],"nsp6":["A88V"]},"labels":{"aa":"nsp6: A88V"}},"children":[{"name":"BA.3","node_attrs":{"div":54,"Nextclade_pango":{"value":"BA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":44},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{}}},{"name":"BA.3.1","node_attrs":{"div":57,"Nextclade_pango":{"value":"BA.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":45},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"clade_display":{"value":"21M (Omicron)"},"partiallyAliased":{"value":"BA.3.1"},"clade_nextstrain":{"value":"21M"},"clade_membership":{"value":"21M"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3791A","C3792A","A22812C"],"S":["N417T"],"nsp3":["A358N"]},"labels":{"aa":"S: N417T; nsp3: A358N","spike_mutations":"N417T"}}}]},{"name":"internal_16e4","node_attrs":{"div":70,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.930835485458374}},"branch_attrs":{"mutations":{"nuc":["C2790T","C9344T","A9424G","C10198T","C17410T","C19955T","A20055G","C21618T","T21633-","A21634-","C21635-","C21636-","C21637-","C21638-","C21639-","T21640-","G21641-","T21762C","-21765T","-21766A","-21767C","-21768A","-21769T","-21770G","T21846C","-21987A","-21988T","-21989G","-21990T","-21991T","-21992T","-21993A","-21994T","-21995T","-22194A","-22195T","-22196T","T22200G","A22688G","A22786C","A22898G","C25000T","C25584T","G27382C","A27383T","T27384C","G29734-","A29735-","G29736-","G29737-","C29738-","C29739-","A29740-"],"ORF6":["D61L"],"S":["T19I","L24-","P25-","P26-","A27S","V67A","-69H","-70V","I95T","-142D","-143V","-144Y","D145Y","-211N","I212L","V213G","T376A","R408S","S446G"],"nsp13":["R392C"],"nsp15":["T112I"],"nsp3":["T24I"],"nsp4":["L264F"]},"labels":{"aa":"ORF6: D61L; S: T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G; nsp13: R392C; nsp15: T112I; nsp3: T24I; nsp4: L264F","clade":"21L","spike_mutations":"T19I, L24-, P25-, P26-, A27S, V67A, -69H, -70V, I95T, -142D, -143V, -144Y, D145Y, -211N, I212L, V213G, T376A, R408S, S446G"}},"children":[{"name":"BA.2","node_attrs":{"div":70,"Nextclade_pango":{"value":"BA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2021-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.930835485458374}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.16","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.223683834075928}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","C29160T"],"N":["T296I"],"nsp1":["V84-","M85-"]},"labels":{"aa":"N: T296I; nsp1: V84-, M85-"}}},{"name":"BA.2.15","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.15"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.828917503356934}},"branch_attrs":{"mutations":{"nuc":["C44T","C9714T","G21753T","C27944T"],"S":["W64L"],"nsp4":["T387I"]},"labels":{"aa":"S: W64L; nsp4: T387I","spike_mutations":"W64L"}}},{"name":"BA.2.19","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.19"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.502110004425049}},"branch_attrs":{"mutations":{"nuc":["C1263T","C16092T"],"nsp2":["T153M"]},"labels":{"aa":"nsp2: T153M"}}},{"name":"internal_c3e54d8c","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.87"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{"nuc":["C18744T"]}},"children":[{"name":"BA.2.87","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2.87"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.277873516082764}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.87.1","node_attrs":{"div":129,"Nextclade_pango":{"value":"BA.2.87.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8217399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":41},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6657453429914796"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.87.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C66T","A309G","A518-","T519-","G520-","C541T","G542A","C2536T","C4012T","G4354T","T4379G","C5184T","C7296T","T7480C","C7764T","G9190T","A10037G","C10702T","A11782G","C12008T","A12791C","C12896T","G15451A","C15925T","C16575T","C17644A","T19364C","C19698A","G21604A","G21606-","T21607-","G21608-","T21609-","T21610-","A21611-","A21612-","T21613-","C21614-","T21615-","T21616-","A21617-","T21618-","A21619-","A21620-","C21621-","C21622-","A21623-","G21624-","A21625-","A21626-","C21627-","T21628-","C21629-","A21630-","A21631-","T21632-","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21786A","C21855T","T21939C","T21967-","T21968-","G21969-","T21970-","A21971-","A21972-","T21973-","G21974-","A21975-","T21976-","C21977-","C21978-","A21979-","T21980-","T21981-","T21982-","T21983-","T21984-","G21985-","G21986-","A21987-","T21988-","G21989-","T21990-","T21991-","T21992-","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-","A21999-","G22017T","G22132T","A22206G","T22552C","A22812C","G22894T","T22896G","C22916A","T22942G","A22995C","T23005G","G23040A","C23423T","T23487G","A23598G","T23633C","G23761A","C23934T","T23948C","A24369G","C25487A","T26311G","G26529A","C26833T","C27128T","C28045T","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-","A28247-","G28248-","A28249-","T28250-","T28251-","T28252-","C28253-","A28254-","C28256T","T28474C","A28715G"],"E":["F23V"],"M":["D3N","A104V"],"N":["T148A"],"ORF3a":["T32N"],"ORF8":["A51V","G66-","S67-","K68E","L118-","D119-","F120-","I121-"],"ORF9b":["L64P"],"S":["C15-","V16-","N17-","L18-","I19-","T20-","R21-","T22-","Q23-","H69-","V70-","G75D","S98F","V126A","C136-","N137-","D138-","P139-","F140-","L141-","D142-","V143-","Y144-","Y145-","H146-","W152L","R190S","D215G","N417T","K444N","V445G","L452M","N460K","K478T","N481K","R493Q","P621S","V642G","K679R","S691P","T791I","Y796H","D936G"],"nsp1":["Q15R","M85-","E93K"],"nsp12":["G671S","L829F"],"nsp13":["Q470K"],"nsp14":["L442S"],"nsp3":["E545D","S554A","P822L","A1526V","S1682F"],"nsp4":["T495A"],"nsp7":["L56F"],"nsp9":["K36Q","P71S"]},"labels":{"aa":"E: F23V; M: D3N, A104V; N: T148A; ORF3a: T32N; ORF8: A51V, G66-, S67-, K68E, L118-, D119-, F120-, I121-; ORF9b: L64P; S: C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G; nsp1: Q15R, M85-, E93K; nsp12: G671S, L829F; nsp13: Q470K; nsp14: L442S; nsp3: E545D, S554A, P822L, A1526V, S1682F; nsp4: T495A; nsp7: L56F; nsp9: K36Q, P71S","spike_mutations":"C15-, V16-, N17-, L18-, I19-, T20-, R21-, T22-, Q23-, H69-, V70-, G75D, S98F, V126A, C136-, N137-, D138-, P139-, F140-, L141-, D142-, V143-, Y144-, Y145-, H146-, W152L, R190S, D215G, N417T, K444N, V445G, L452M, N460K, K478T, N481K, R493Q, P621S, V642G, K679R, S691P, T791I, Y796H, D936G"}}}]},{"name":"NODE_0000662","node_attrs":{"div":71,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-1.482762336730957}},"branch_attrs":{"mutations":{"nuc":["C9866T"],"nsp4":["L438F"]},"labels":{"aa":"nsp4: L438F"}},"children":[{"name":"BA.2.1","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.958613395690918}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}}},{"name":"BA.2.11","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04096000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.020681381225586}},"branch_attrs":{"mutations":{"nuc":["T7820C","T22917G","G29868A"],"S":["L452R"],"nsp3":["S1701P"]},"labels":{"aa":"S: L452R; nsp3: S1701P","spike_mutations":"L452R"}}},{"name":"BA.2.18","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.18"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.0617408752441406}},"branch_attrs":{"mutations":{"nuc":["A22812C","C23248T"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}},{"name":"BA.2.20","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9340405464172363}},"branch_attrs":{"mutations":{"nuc":["A22005C","C28498T","G29315C"],"N":["D348H"],"ORF9b":["T72I"],"S":["N148T"]},"labels":{"aa":"N: D348H; ORF9b: T72I; S: N148T","spike_mutations":"N148T"}}},{"name":"BA.2.24","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.03172000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.01261797446067892"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.24"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.043281078338623}},"branch_attrs":{"mutations":{"nuc":["G22577A"],"S":["D339N"]},"labels":{"aa":"S: D339N","spike_mutations":"D339N"}}},{"name":"BA.2.26","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.26"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5770962238311768}},"branch_attrs":{"mutations":{"nuc":["C2003T","C8739T"],"nsp2":["L400F"],"nsp4":["T62I"]},"labels":{"aa":"nsp2: L400F; nsp4: T62I"}}},{"name":"BA.2.28","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.28"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.954390048980713}},"branch_attrs":{"mutations":{"nuc":["A6610C","C9360T","A25457G"],"ORF3a":["D22G"],"nsp3":["R1297S"],"nsp4":["T269I"]},"labels":{"aa":"ORF3a: D22G; nsp3: R1297S; nsp4: T269I"}}},{"name":"BA.2.27","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.27"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9474265575408936}},"branch_attrs":{"mutations":{"nuc":["T2C","G3514A"],"nsp3":["M265I"]},"labels":{"aa":"nsp3: M265I"}}},{"name":"BA.2.29","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.29"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2460474967956543}},"branch_attrs":{"mutations":{"nuc":["G2012A"],"nsp2":["A403T"]},"labels":{"aa":"nsp2: A403T"}}},{"name":"BA.2.30","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.30"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.186188220977783}},"branch_attrs":{"mutations":{"nuc":["C3602T","G26109T"],"ORF3a":["E239D"],"nsp3":["H295Y"]},"labels":{"aa":"ORF3a: E239D; nsp3: H295Y"}}},{"name":"BA.2.32","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.32"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.723731756210327}},"branch_attrs":{"mutations":{"nuc":["C22624T","G27589T"],"ORF7a":["A66S"]},"labels":{"aa":"ORF7a: A66S"}}},{"name":"BA.2.4","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7230255603790283}},"branch_attrs":{"mutations":{"nuc":["C21T","T27374A"],"ORF6":["M58K"]},"labels":{"aa":"ORF6: M58K"}}},{"name":"BA.2.39","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.39"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3410820960998535}},"branch_attrs":{"mutations":{"nuc":["C9502T","T9892C","G15672T","G20176T","A20347G","C24134A"],"S":["L858I"],"nsp12":["E744D"],"nsp15":["V186F","S243G"]},"labels":{"aa":"S: L858I; nsp12: E744D; nsp15: V186F, S243G","spike_mutations":"L858I"}}},{"name":"BA.2.41","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.41"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7298529148101807}},"branch_attrs":{"mutations":{"nuc":["C4202T","A25253T"],"S":["T1231S"]},"labels":{"aa":"S: T1231S","spike_mutations":"T1231S"}}},{"name":"BA.2.42","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.42"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["C1348T","T8164C","T21765C","A29407T"],"N":["E378D"],"S":["I68T"]},"labels":{"aa":"N: E378D; S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.43","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11284999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.43"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.411208152770996}},"branch_attrs":{"mutations":{"nuc":["A2568G","T22674A","G25166C"],"S":["F371Y","E1202Q"],"nsp2":["Q588R"]},"labels":{"aa":"S: F371Y, E1202Q; nsp2: Q588R","spike_mutations":"F371Y, E1202Q"}}},{"name":"BA.2.46","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.46"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.784235954284668}},"branch_attrs":{"mutations":{"nuc":["C36T","C44T","C17883T","G25019T","C26296A","A28654G"],"E":["L18I"],"S":["D1153Y"]},"labels":{"aa":"E: L18I; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.5","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5876340866088867}},"branch_attrs":{"mutations":{"nuc":["C3317T"],"nsp3":["P200S"]},"labels":{"aa":"nsp3: P200S"}}},{"name":"BA.2.48","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.48"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7899765968322754}},"branch_attrs":{"mutations":{"nuc":["C4230T","T4579A","A15972G","C16779T","A22305C"],"S":["Y248S"],"nsp3":["T504I"]},"labels":{"aa":"S: Y248S; nsp3: T504I","spike_mutations":"Y248S"}}},{"name":"BA.2.50","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.50"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.211312770843506}},"branch_attrs":{"mutations":{"nuc":["C2749T","C13620T","T22197C"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.54","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.54"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.137404441833496}},"branch_attrs":{"mutations":{"nuc":["C3874T","C19017T","A22305C","G25166C"],"S":["Y248S","E1202Q"]},"labels":{"aa":"S: Y248S, E1202Q","spike_mutations":"Y248S, E1202Q"}}},{"name":"BA.2.55","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.55"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.214793682098389}},"branch_attrs":{"mutations":{"nuc":["T21765C","A24383T"],"S":["I68T","T941S"]},"labels":{"aa":"S: I68T, T941S","spike_mutations":"I68T, T941S"}}},{"name":"BA.2.58","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.58"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0507121086120605}},"branch_attrs":{"mutations":{"nuc":["G25352C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"BA.2.61","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.61"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.497011184692383}},"branch_attrs":{"mutations":{"nuc":["C4276T","T21752A","A25168G"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.59","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.59"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.60070276260376}},"branch_attrs":{"mutations":{"nuc":["G25019T","C25791T","A28338G"],"N":["D22G"],"ORF9b":["I19V"],"S":["D1153Y"]},"labels":{"aa":"N: D22G; ORF9b: I19V; S: D1153Y","spike_mutations":"D1153Y"}}},{"name":"BA.2.60","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.60"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.602741718292236}},"branch_attrs":{"mutations":{"nuc":["A1916T","C4754T","C9967T","C14625T","G24947A","C25046T"],"S":["V1129I","P1162S"],"nsp2":["T371S"],"nsp3":["P679S"]},"labels":{"aa":"S: V1129I, P1162S; nsp2: T371S; nsp3: P679S","spike_mutations":"V1129I, P1162S"}}},{"name":"BA.2.62","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.62"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9947850704193115}},"branch_attrs":{"mutations":{"nuc":["C25669T"],"ORF3a":["H93Y"]},"labels":{"aa":"ORF3a: H93Y"}}},{"name":"BA.2.64","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.64"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.5229573249816895}},"branch_attrs":{"mutations":{"nuc":["C3961T","G11266T","T28678C"],"nsp6":["L98F"]},"labels":{"aa":"nsp6: L98F"}}},{"name":"BA.2.65","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.65"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.8447983264923096}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"BA.2.63","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.63"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.1785149574279785}},"branch_attrs":{"mutations":{"nuc":["C3096T","G18674A"],"nsp14":["R212K"],"nsp3":["S126L"]},"labels":{"aa":"nsp14: R212K; nsp3: S126L"}}},{"name":"BA.2.70","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.70"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.472323894500732}},"branch_attrs":{"mutations":{"nuc":["A866G","G5230T","G8828A","C9286T"],"nsp2":["I21V"],"nsp3":["K837N"],"nsp4":["A92T"]},"labels":{"aa":"nsp2: I21V; nsp3: K837N; nsp4: A92T"}}},{"name":"BA.2.77","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.2.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9213199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3221048136122174"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.77"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.605336666107178}},"branch_attrs":{"mutations":{"nuc":["C44T","C10332T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22580A","A22629C","T22917G","G23040A","G24368C","G25691T","C26305T","C26533T"],"E":["L21F"],"M":["S4F"],"ORF3a":["G100V"],"S":["H69-","V70-","E340K","K356T","L452R","R493Q","D936H"],"nsp5":["T93I"]},"labels":{"aa":"E: L21F; M: S4F; ORF3a: G100V; S: H69-, V70-, E340K, K356T, L452R, R493Q, D936H; nsp5: T93I","spike_mutations":"H69-, V70-, E340K, K356T, L452R, R493Q, D936H"}}},{"name":"BA.2.82","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.82"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.82"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.216998100280762}},"branch_attrs":{"mutations":{"nuc":["A7201G","G12278A","C13197T","T21765C","G22599C"],"S":["I68T","R346T"],"nsp10":["T58I"],"nsp8":["A63T"]},"labels":{"aa":"S: I68T, R346T; nsp10: T58I; nsp8: A63T","spike_mutations":"I68T, R346T"}}},{"name":"BA.2.8","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.326139211654663}},"branch_attrs":{"mutations":{"nuc":["T21048C","G25483A"],"ORF3a":["A31T"]},"labels":{"aa":"ORF3a: A31T"}}},{"name":"BA.2.83","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.83"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.12534"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.22071783986880583"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.83"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C6701T","A6785G","C10340T","C13197T","C19983T","T21180C","C21587A","T21752C","G22203T","G22317A","G22898A","T22942G","A22995C","G23040A","G24834A","G25352T","G26416C","A28467G"],"E":["V58L"],"N":["K65R"],"ORF9b":["N62D"],"S":["P9T","W64R","R214L","G252D","G446S","N460K","K478T","R493Q","R1091H","V1264L"],"nsp10":["T58I"],"nsp3":["L1328F","T1356A"],"nsp5":["P96S"]},"labels":{"aa":"E: V58L; N: K65R; ORF9b: N62D; S: P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L; nsp10: T58I; nsp3: L1328F, T1356A; nsp5: P96S","spike_mutations":"P9T, W64R, R214L, G252D, G446S, N460K, K478T, R493Q, R1091H, V1264L"}}},{"name":"BA.2.85","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.85"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.85"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.299220561981201}},"branch_attrs":{"mutations":{"nuc":["C44T","C225T","A23513G","C28432T","A28877T","G28878C"],"ORF9b":["S50L"],"S":["I651V"]},"labels":{"aa":"ORF9b: S50L; S: I651V","spike_mutations":"I651V"}}},{"name":"NODE_0000663","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{"nuc":["T2C","C4893T","C12525T","T25224C"],"S":["I1221T"],"nsp3":["T725I"],"nsp8":["T145I"]},"labels":{"aa":"S: I1221T; nsp3: T725I; nsp8: T145I","spike_mutations":"I1221T"}},"children":[{"name":"BA.2.2","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.5651278495788574}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.2.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.237253189086914}},"branch_attrs":{"mutations":{"nuc":["G7393T","T10696C","C26789T","A28119G","T28897A"],"ORF8":["I76V"]},"labels":{"aa":"ORF8: I76V"}}}]},{"name":"NODE_0000664","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.123868942260742}},"branch_attrs":{"mutations":{"nuc":["G670T"],"nsp1":["R135S"]},"labels":{"aa":"nsp1: R135S"}},"children":[{"name":"BA.2.23","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":49},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.123868942260742}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.23.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.23.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.136962413787842}},"branch_attrs":{"mutations":{"nuc":["C7869T","A28389T"],"N":["Q39L"],"ORF9b":["N36Y"],"nsp3":["S1717L"]},"labels":{"aa":"N: Q39L; ORF9b: N36Y; nsp3: S1717L"}}}]},{"name":"internal_04a9","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{"nuc":["G12071A"],"nsp7":["D77N"]},"labels":{"aa":"nsp7: D77N"}},"children":[{"name":"BA.2.31","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8205366134643555}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.31.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.31.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.867143630981445}},"branch_attrs":{"mutations":{"nuc":["T19452C","T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}}]},{"name":"NODE_0000666","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.892359972000122}},"branch_attrs":{"mutations":{"nuc":["C6196T"]}},"children":[{"name":"BA.2.33","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.33"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.086283206939697}},"branch_attrs":{"mutations":{"nuc":["C3903T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"nsp3":["P395L"]},"labels":{"aa":"nsp3: P395L"}}},{"name":"BA.2.35","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04096000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.35"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.5697021484375}},"branch_attrs":{"mutations":{"nuc":["T22917G","C27128T","G28936T"],"N":["L221F"],"S":["L452R"]},"labels":{"aa":"N: L221F; S: L452R","spike_mutations":"L452R"}}}]},{"name":"internal_ad79","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.40"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.795884847640991}},"branch_attrs":{"mutations":{"nuc":["G19677T"],"nsp15":["Q19H"]},"labels":{"aa":"nsp15: Q19H"}},"children":[{"name":"BA.2.40","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.795884847640991}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.40.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.40.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.40.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.748093843460083}},"branch_attrs":{"mutations":{"nuc":["C21306T","A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}}}]},{"name":"NODE_0000668","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.56"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.964897632598877}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.56","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.964897632598877}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.56.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.56.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.56.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.696688652038574}},"branch_attrs":{"mutations":{"nuc":["C21767T","G24219T"],"S":["H69Y","W886L"]},"labels":{"aa":"S: H69Y, W886L","spike_mutations":"H69Y, W886L"}}}]},{"name":"NODE_0000669","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.636354446411133}},"branch_attrs":{"mutations":{"nuc":["T16342C"],"nsp13":["S36P"]},"labels":{"aa":"nsp13: S36P"}},"children":[{"name":"BA.2.10","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.636354446411133}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.10.3","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.07940673828125}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.10.2","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.684506416320801}},"branch_attrs":{"mutations":{"nuc":["G26426T","T29867-","G29868-"],"E":["R61L"]},"labels":{"aa":"E: R61L"}}},{"name":"BA.2.10.4","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.2.10.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.73328"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3166622371297313"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.095335483551025}},"branch_attrs":{"mutations":{"nuc":["G4255A","G15451A","T21752C","A21987G","G22898A","T23018C","T23019C","G23040A","T23042C","C24990T","C27707T"],"ORF7a":["A105V"],"S":["W64R","D142G","G446S","F486P","R493Q","S494P","P1143L"],"nsp12":["G671S"]},"labels":{"aa":"ORF7a: A105V; S: W64R, D142G, G446S, F486P, R493Q, S494P, P1143L; nsp12: G671S","spike_mutations":"W64R, D142G, G446S, F486P, R493Q, S494P, P1143L"}}},{"name":"internal_ffa6","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.472019672393799}},"branch_attrs":{"mutations":{"nuc":["A1C","G23955A"],"S":["G798D"]},"labels":{"aa":"S: G798D","spike_mutations":"G798D"}},"children":[{"name":"BA.2.10.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.472019672393799}},"branch_attrs":{"mutations":{}}},{"name":"BJ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.09519000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6181860283242497"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.10.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A405G","G15451A","C15738T","T15939C","T17859C","T21810C","T21992-","A21993-","T21994-","C22000A","C22109G","G22200A","G22577C","G22599C","C22664A","G22895C","T22896C","G22898A","T23010C","T23030G","G24570T","G26529T","T27722C","G28079T","C29118T"],"M":["D3Y"],"N":["T282I"],"ORF7a":["I110T"],"S":["V83A","Y144-","H146Q","Q183E","G213E","D339H","R346T","L368I","V445P","G446S","V483A","F490V","S1003I"],"nsp1":["K47R"],"nsp12":["G671S"]},"labels":{"aa":"M: D3Y; N: T282I; ORF7a: I110T; S: V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I; nsp1: K47R; nsp12: G671S","spike_mutations":"V83A, Y144-, H146Q, Q183E, G213E, D339H, R346T, L368I, V445P, G446S, V483A, F490V, S1003I"}}}]}]},{"name":"NODE_0000671","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-1.6233329772949219}},"branch_attrs":{"mutations":{"nuc":["C22792T"]}},"children":[{"name":"BA.2.14","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.14"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6388018131256104}},"branch_attrs":{"mutations":{"nuc":["G21753T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["W64L"]},"labels":{"aa":"S: W64L","spike_mutations":"W64L"}}},{"name":"BA.2.22","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.22"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2793381214141846}},"branch_attrs":{"mutations":{"nuc":["G12163T","C17676T","T22119C"],"S":["F186S"],"nsp8":["Q24H"]},"labels":{"aa":"S: F186S; nsp8: Q24H","spike_mutations":"F186S"}}},{"name":"BA.2.34","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.34"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.040848731994629}},"branch_attrs":{"mutations":{"nuc":["G29000A"],"N":["G243S"]},"labels":{"aa":"N: G243S"}}},{"name":"BA.2.36","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.36"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.0697343349456787}},"branch_attrs":{"mutations":{"nuc":["T21765C"],"S":["I68T"]},"labels":{"aa":"S: I68T","spike_mutations":"I68T"}}},{"name":"BA.2.45","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.30756000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.45"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6386520862579346}},"branch_attrs":{"mutations":{"nuc":["T2G","C9430T","T22907C"],"S":["Y449H"]},"labels":{"aa":"S: Y449H","spike_mutations":"Y449H"}}},{"name":"BA.2.47","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.47"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.130118370056152}},"branch_attrs":{"mutations":{"nuc":["G1018T","T22304C","C25344A"],"S":["Y248H","S1261Y"],"nsp2":["L71F"]},"labels":{"aa":"S: Y248H, S1261Y; nsp2: L71F","spike_mutations":"Y248H, S1261Y"}}},{"name":"BA.2.49","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.49"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7807657718658447}},"branch_attrs":{"mutations":{"nuc":["C13620T","A29403T"],"N":["D377V"]},"labels":{"aa":"N: D377V"}}},{"name":"BA.2.51","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.51"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.694986581802368}},"branch_attrs":{"mutations":{"nuc":["C23802T"],"S":["T747I"]},"labels":{"aa":"S: T747I","spike_mutations":"T747I"}}},{"name":"BA.2.52","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.52"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8800225257873535}},"branch_attrs":{"mutations":{"nuc":["T2228C"],"nsp2":["C475R"]},"labels":{"aa":"nsp2: C475R"}}},{"name":"BA.2.53","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.33552999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1085477953061414"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.53"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["C8605T","C10681T","C17766T","T22907A","T25306C","C28677T"],"N":["T135I"],"S":["Y449N"]},"labels":{"aa":"N: T135I; S: Y449N","spike_mutations":"Y449N"}}},{"name":"BA.2.6","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6629879474639893}},"branch_attrs":{"mutations":{"nuc":["G25471C"],"ORF3a":["D27H"]},"labels":{"aa":"ORF3a: D27H"}}},{"name":"BA.2.7","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.356294631958008}},"branch_attrs":{"mutations":{"nuc":["C6636T"],"nsp3":["T1306I"]},"labels":{"aa":"nsp3: T1306I"}}},{"name":"BA.2.69","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.69"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.939220905303955}},"branch_attrs":{"mutations":{"nuc":["A14827C"],"nsp12":["M463L"]},"labels":{"aa":"nsp12: M463L"}}},{"name":"BA.2.72","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.72"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.616490125656128}},"branch_attrs":{"mutations":{"nuc":["T22197C","C24865T"],"S":["L212S"]},"labels":{"aa":"S: L212S","spike_mutations":"L212S"}}},{"name":"BA.2.71","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.71"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.660243034362793}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.80","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.80"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10838000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.31190394480802347"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.80"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.6446309089660645}},"branch_attrs":{"mutations":{"nuc":["A2783C","C4475T","A9343G","G22599C","A22629C","C26873T","C27923T","-29759T"],"S":["R346T","K356T"],"nsp3":["N22H","R586C"]},"labels":{"aa":"S: R346T, K356T; nsp3: N22H, R586C","spike_mutations":"R346T, K356T"}}},{"name":"BA.2.81","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.81"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.81"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.347172260284424}},"branch_attrs":{"mutations":{"nuc":["G6337T","T14171C","C17502T","C22916A"],"S":["L452M"],"nsp12":["I244T"]},"labels":{"aa":"S: L452M; nsp12: I244T","spike_mutations":"L452M"}}},{"name":"internal_6dd8","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{"nuc":["A1652G"],"nsp2":["I283V"]},"labels":{"aa":"nsp2: I283V"}},"children":[{"name":"BA.2.25","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.489654064178467}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.25.1","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.25.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.99613094329834}},"branch_attrs":{"mutations":{"nuc":["C22624T","G25681A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}}]},{"name":"internal_8e5d","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.7391469478607178}},"branch_attrs":{"mutations":{"nuc":["A23767G"]}},"children":[{"name":"BA.2.44","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11284999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.021062466983009277"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.44"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.218840599060059}},"branch_attrs":{"mutations":{"nuc":["C19011T","T22674A"],"S":["F371Y"]},"labels":{"aa":"S: F371Y","spike_mutations":"F371Y"}}},{"name":"internal_6b14","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{"nuc":["C22916A"],"S":["L452M"]},"labels":{"aa":"S: L452M","spike_mutations":"L452M"}},"children":[{"name":"BA.2.13","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.553999662399292}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.13.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.13.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.024046421051025}},"branch_attrs":{"mutations":{"nuc":["C16954T","A24383T","C28507T"],"ORF9b":["A75V"],"S":["T941S"]},"labels":{"aa":"ORF9b: A75V; S: T941S","spike_mutations":"T941S"}}}]}]},{"name":"NODE_0000675","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.191652774810791}},"branch_attrs":{"mutations":{"nuc":["A1C","C25624T"],"ORF3a":["H78Y"]},"labels":{"aa":"ORF3a: H78Y"}},"children":[{"name":"BA.2.9","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.191652774810791}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.9.1","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.2.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.2822980880737305}},"branch_attrs":{"mutations":{"nuc":["A1230G","T3610C","T4111C","C15342T","C20178T","C22916A","A24433G","C28472T","G29508T"],"N":["P67S","S412I"],"S":["L452M"],"nsp2":["K142R"]},"labels":{"aa":"N: P67S, S412I; S: L452M; nsp2: K142R","spike_mutations":"L452M"}}},{"name":"BA.2.9.3","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.352867364883423}},"branch_attrs":{"mutations":{"nuc":["T21752C"],"S":["W64R"]},"labels":{"aa":"S: W64R","spike_mutations":"W64R"}}},{"name":"BA.2.9.2","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.620241165161133}},"branch_attrs":{"mutations":{"nuc":["C6285T"],"nsp3":["T1189I"]},"labels":{"aa":"nsp3: T1189I"}}},{"name":"BA.2.9.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.9.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.284677982330322}},"branch_attrs":{"mutations":{"nuc":["C18267T","C21911T","G22599C","C27406T"],"ORF7a":["L5F"],"S":["R346T"]},"labels":{"aa":"ORF7a: L5F; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.2.9.5","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.9.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.2389769554138184}},"branch_attrs":{"mutations":{"nuc":["T4443C"],"nsp3":["V575A"]},"labels":{"aa":"nsp3: V575A"}}},{"name":"BA.2.9.6","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.9.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.504534721374512}},"branch_attrs":{"mutations":{"nuc":["G2144T","C5183T","C22916A"],"S":["L452M"],"nsp2":["V447F"],"nsp3":["P822S"]},"labels":{"aa":"S: L452M; nsp2: V447F; nsp3: P822S","spike_mutations":"L452M"}}},{"name":"BA.2.9.7","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.2.9.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.9.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.828468084335327}},"branch_attrs":{"mutations":{"nuc":["C1426T","C2197T","C3602T","A17645G","C23751T","T27383C","C28435T"],"ORF6":["L61P"],"ORF9b":["P51L"],"S":["S730F"],"nsp13":["Q470R"],"nsp3":["H295Y"]},"labels":{"aa":"ORF6: L61P; ORF9b: P51L; S: S730F; nsp13: Q470R; nsp3: H295Y","spike_mutations":"S730F"}}}]}]},{"name":"NODE_0000676","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{"nuc":["C8991T","C25810T"],"ORF3a":["L140F"],"nsp4":["A146V"]},"labels":{"aa":"ORF3a: L140F; nsp4: A146V"}},"children":[{"name":"BA.2.3.1","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.1285183429718018}},"branch_attrs":{"mutations":{"nuc":["C23591G"],"S":["Q677E"]},"labels":{"aa":"S: Q677E","spike_mutations":"Q677E"}}},{"name":"BA.2.3","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-02-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.485121965408325}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.3.10","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0984086990356445}},"branch_attrs":{"mutations":{"nuc":["G25776T"],"ORF3a":["W128C"]},"labels":{"aa":"ORF3a: W128C"}}},{"name":"BA.2.3.11","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7979328632354736}},"branch_attrs":{"mutations":{"nuc":["C13326T"],"nsp10":["T101I"]},"labels":{"aa":"nsp10: T101I"}}},{"name":"BA.2.3.13","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.13"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.3481760025024414}},"branch_attrs":{"mutations":{"nuc":["C10277T","C19317T"],"nsp5":["L75F"]},"labels":{"aa":"nsp5: L75F"}}},{"name":"BA.2.3.12","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9230539798736572}},"branch_attrs":{"mutations":{"nuc":["T2C","C12525T","C18508T"],"nsp14":["L157F"],"nsp8":["T145I"]},"labels":{"aa":"nsp14: L157F; nsp8: T145I"}}},{"name":"BA.2.3.17","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.17"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8992514610290527}},"branch_attrs":{"mutations":{"nuc":["G2659T","C13730T"],"nsp12":["A97V"],"nsp2":["K618N"]},"labels":{"aa":"nsp12: A97V; nsp2: K618N"}}},{"name":"BA.2.3.15","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.15"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8729300498962402}},"branch_attrs":{"mutations":{"nuc":["C18060T","G18315A","T22207G"],"S":["D215E"]},"labels":{"aa":"S: D215E","spike_mutations":"D215E"}}},{"name":"BA.2.3.19","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.3.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":6},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.19"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.702374458312988}},"branch_attrs":{"mutations":{"nuc":["C44T","T6980G","C21859T","A22812C","T24115C","-28362G","-28363A","-28364G","-28365A","-28366A","-28367C","-28368G","-28369C","-28370A"],"N":["-31E","-32R","-33S"],"ORF9b":["-27E","-28N","-29A"],"S":["N417T"],"nsp3":["C1421G"]},"labels":{"aa":"N: -31E, -32R, -33S; ORF9b: -27E, -28N, -29A; S: N417T; nsp3: C1421G","spike_mutations":"N417T"}}},{"name":"BA.2.3.14","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.14"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.958418846130371}},"branch_attrs":{"mutations":{"nuc":["T2845C","A9930C"],"nsp4":["D459A"]},"labels":{"aa":"nsp4: D459A"}}},{"name":"BA.2.3.18","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.18"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.462870121002197}},"branch_attrs":{"mutations":{"nuc":["C16699T","T17771G","T29867A"],"nsp13":["R155C","I512S"]},"labels":{"aa":"nsp13: R155C, I512S"}}},{"name":"BA.2.3.5","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3020405769348145}},"branch_attrs":{"mutations":{"nuc":["C936T"],"nsp2":["T44I"]},"labels":{"aa":"nsp2: T44I"}}},{"name":"BA.2.3.7","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8020246028900146}},"branch_attrs":{"mutations":{"nuc":["C2156T","A21851G","G29239A"],"N":["M322I"],"S":["K97E"],"nsp2":["L451F"]},"labels":{"aa":"N: M322I; S: K97E; nsp2: L451F","spike_mutations":"K97E"}}},{"name":"BA.2.3.4","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.009455680847168}},"branch_attrs":{"mutations":{"nuc":["C7600T","C13423T","A23484G"],"S":["N641S"]},"labels":{"aa":"S: N641S","spike_mutations":"N641S"}}},{"name":"BA.2.3.8","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T2C","C44T","C4980T","A5368C","C10165T","C17649T"],"nsp3":["T754I","R883S"]},"labels":{"aa":"nsp3: T754I, R883S"}}},{"name":"BA.2.3.9","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8521339893341064}},"branch_attrs":{"mutations":{"nuc":["G28986T"],"N":["G238V"]},"labels":{"aa":"N: G238V"}}},{"name":"internal_305a","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9121458530426025}},"branch_attrs":{"mutations":{"nuc":["C28087T"],"ORF8":["A65V"]},"labels":{"aa":"ORF8: A65V"}},"children":[{"name":"BA.2.3.16","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9121458530426025}},"branch_attrs":{"mutations":{}}},{"name":"BP.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9456899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43687237373984505"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.16.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6532T","G10193C","C13197T","T15382C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22599C","G22770A","C22916A","C23271T","C23846G","C24117T","C26533T","C26681T"],"M":["S4F"],"S":["H69-","V70-","R346T","R403K","L452M","A570V","Q762E","A852V"],"nsp10":["T58I"],"nsp3":["E1271D"],"nsp5":["E47Q"]},"labels":{"aa":"M: S4F; S: H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V; nsp10: T58I; nsp3: E1271D; nsp5: E47Q","spike_mutations":"H69-, V70-, R346T, R403K, L452M, A570V, Q762E, A852V"}}}]},{"name":"internal_6a11","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.601434707641602}},"branch_attrs":{"mutations":{"nuc":["C21588T"],"S":["P9L"]},"labels":{"aa":"S: P9L","spike_mutations":"P9L"}},"children":[{"name":"BA.2.3.21","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06758"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.828201770782471}},"branch_attrs":{"mutations":{"nuc":["G23040A"],"S":["R493Q"]},"labels":{"aa":"S: R493Q","spike_mutations":"R493Q"}}},{"name":"DD.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"DD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9683399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4733677107846063"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.21.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C9693T","T17901C","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T21992-","A21993-","T21994-","G22200A","G22577A","G22599C","T22907A","T22942G","T23005A","G23040T","G25177T","A28877T","G28878C"],"S":["H69-","V70-","Y144-","G213E","D339N","R346T","Y449N","N460K","N481K","R493L","K1205N"],"nsp4":["A380V"]},"labels":{"aa":"S: H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N; nsp4: A380V","spike_mutations":"H69-, V70-, Y144-, G213E, D339N, R346T, Y449N, N460K, N481K, R493L, K1205N"}}}]},{"name":"NODE_0000679","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.17149543762207}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}},"children":[{"name":"BA.2.3.22","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.2.3.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.37526000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.42289430257523936"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.22"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2842T","C4582T","C17822T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G22017T","A22194-","T22195-","T22196-","G22599C","A22812C","T23030G","T23031C","G24386T","A27243G","C27707T"],"ORF6":["I14M"],"ORF7a":["A105V"],"S":["H69-","V70-","W152L","N211-","L212I","R346T","N417T","F490A","A942S"],"nsp13":["P529L"]},"labels":{"aa":"ORF6: I14M; ORF7a: A105V; S: H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S; nsp13: P529L","spike_mutations":"H69-, V70-, W152L, N211-, L212I, R346T, N417T, F490A, A942S"}}},{"name":"BA.2.3.6","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0095014572143555}},"branch_attrs":{"mutations":{"nuc":["C4990T"]}}}]},{"name":"internal_019b","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{"nuc":["C26408T"],"E":["S55F"]},"labels":{"aa":"E: S55F"}},"children":[{"name":"BA.2.3.2","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9326364994049072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000681","node_attrs":{"div":99,"Nextclade_pango":{"value":"BS.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C44T","C151T","G293A","C629T","A2442C","C4763T","A5405G","A5648C","C6573T","C9979T","A10393C","C11750T","C15654T","C16418T","C20946T","T21992-","A21993-","T21994-","G22332T","G22599C","T22917G","T22942G","G22988A","G23040A","C23481T","T26733C","T27266-","T27267-","A27268-","A27269-","A27270-","G27271-","T27272-","T27273-","T27274-","C27275-","C27276-","A27277-","T27278-","T27279-","T27280-","G27281-","G27282-","A27283-","A27284-","T27285-","C27286-","T27287-","T27288-","G27289-","A27290-","T27291-","T27292-","A27293-","C27294-","A27295-","T27296-","C27297-","A27298-","T27299-","A27300-","C27707T","C28677T"],"M":["Y71H"],"N":["T135I"],"ORF6":["F22-","K23-","V24-","S25-","I26-","W27-","N28-","L29-","D30-","Y31-","I32-","I33-"],"ORF7a":["A105V"],"S":["Y144-","G257V","R346T","L452R","N460K","G476S","R493Q","S640F"],"nsp1":["E10K","L122F"],"nsp13":["T61I"],"nsp2":["E546A"],"nsp3":["H682Y","I896V","K977Q","S1285F"],"nsp6":["L260F"]},"labels":{"aa":"M: Y71H; N: T135I; ORF6: F22-, K23-, V24-, S25-, I26-, W27-, N28-, L29-, D30-, Y31-, I32-, I33-; ORF7a: A105V; S: Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F; nsp1: E10K, L122F; nsp13: T61I; nsp2: E546A; nsp3: H682Y, I896V, K977Q, S1285F; nsp6: L260F","spike_mutations":"Y144-, G257V, R346T, L452R, N460K, G476S, R493Q, S640F"}},"children":[{"name":"BS.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"BS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66194"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-09-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.49181526572268314"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"BS.1.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"BS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6589000000000002"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6029918987948071"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["A22629C","C27752T"],"ORF7a":["T120I"],"S":["K356T"]},"labels":{"aa":"ORF7a: T120I; S: K356T","spike_mutations":"K356T"}}},{"name":"BS.1.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"BS.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66821"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF6:34-62"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4975483601650658"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.2.1.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T9580C","A13488G","C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}}}]}]},{"name":"NODE_0000682","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{"nuc":["A1C","C1471T","C2445T","T5406C","A6770G","C6786T","C8208T","C10189T","A12030G","C17678T","C18252T","T22020C","T22054G","C22295A","G22332A","A22893G","A22910G","C22916A","T22942G","G23012A","C23013G","G23040A","C28550A"],"ORF9b":["D89E"],"S":["M153T","N164K","H245N","G257D","K444R","N450D","L452M","N460K","A484R","R493Q"],"nsp13":["T481M"],"nsp2":["T547I"],"nsp3":["I896T","M1351V","T1356I","T1830I"],"nsp7":["Q63R"]},"labels":{"aa":"ORF9b: D89E; S: M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q; nsp13: T481M; nsp2: T547I; nsp3: I896T, M1351V, T1356I, T1830I; nsp7: Q63R","spike_mutations":"M153T, N164K, H245N, G257D, K444R, N450D, L452M, N460K, A484R, R493Q"}},"children":[{"name":"BA.2.3.20","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.3.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.172666549682617}},"branch_attrs":{"mutations":{}}},{"name":"CM.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.749448776245117}},"branch_attrs":{"mutations":{"nuc":["A21612G","T22312C"],"S":["N17S"]},"labels":{"aa":"S: N17S","spike_mutations":"N17S"}}},{"name":"CM.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.8190299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7593324873420084"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.10"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.709164619445801}},"branch_attrs":{"mutations":{"nuc":["T22896C","A22995C"],"S":["V445A","K478T"]},"labels":{"aa":"S: V445A, K478T","spike_mutations":"V445A, K478T"}}},{"name":"NODE_0000683","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["A13904G","C26822T"],"nsp12":["D155G"]},"labels":{"aa":"nsp12: D155G"}},"children":[{"name":"CM.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"CM.4.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.91683"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7016283989012374"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.4.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22522T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_d8d0","node_attrs":{"div":97,"Nextclade_pango":{"value":"CM.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G354C"],"nsp1":["G30A"]},"labels":{"aa":"nsp1: G30A"}},"children":[{"name":"CM.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"CM.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{}}},{"name":"CM.6.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"CM.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9440299999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8143059671640498"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.6.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C44T","A2514G","C6471T","C12733T","C21306T","G22604T","T22672C"],"S":["A348S"],"nsp2":["E570G"],"nsp3":["T1251I"]},"labels":{"aa":"S: A348S; nsp2: E570G; nsp3: T1251I","spike_mutations":"A348S"}}}]},{"name":"internal_7ac4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C10802T"]}},"children":[{"name":"CM.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{}}},{"name":"CM.5.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["A23586G"],"S":["Q675R"]},"labels":{"aa":"S: Q675R","spike_mutations":"Q675R"}}},{"name":"CM.5.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.5.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.721927642822266}},"branch_attrs":{"mutations":{"nuc":["G23016A"],"S":["G485D"]},"labels":{"aa":"S: G485D","spike_mutations":"G485D"}}}]},{"name":"internal_fc49","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{"nuc":["T5182C","G22898A"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}},"children":[{"name":"CM.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.99403"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7255583352017505"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.538283348083496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000687","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G14622A","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.8.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"CM.8.1.2","node_attrs":{"div":103,"Nextclade_pango":{"value":"CM.8.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C19185T","A22002T","C25207T"],"S":["K147I"]},"labels":{"aa":"S: K147I","spike_mutations":"K147I"}}},{"name":"CM.8.1.4","node_attrs":{"div":102,"Nextclade_pango":{"value":"CM.8.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A18835G","C29640T"],"ORF10":["A28V"],"nsp14":["N266D"]},"labels":{"aa":"ORF10: A28V; nsp14: N266D"}}},{"name":"NODE_0000688","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2068C"]}},"children":[{"name":"CM.8.1.3","node_attrs":{"div":104,"Nextclade_pango":{"value":"CM.8.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4057C","T25376C","C27688T"],"ORF7a":["P99S"],"S":["Y1272H"]},"labels":{"aa":"ORF7a: P99S; S: Y1272H","spike_mutations":"Y1272H"}}},{"name":"CM.8.1.5","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.5"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G7393T","A22010G","T22304C","C28737T"],"N":["A155V"],"S":["K150E","Y248H"]},"labels":{"aa":"N: A155V; S: K150E, Y248H","spike_mutations":"K150E, Y248H"}}},{"name":"NODE_0000689","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C16391T","C18348A","T21435C","A22003T"],"S":["K147N"],"nsp13":["A52V"]},"labels":{"aa":"S: K147N; nsp13: A52V","spike_mutations":"K147N"}},"children":[{"name":"CM.8.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.17483999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9242014092872922"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"FV.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.28625999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0761544902802131"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.8.1.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["G22599C","G26553C"],"M":["E11Q"],"S":["R346T"]},"labels":{"aa":"M: E11Q; S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"NODE_0000690","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.2.3.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.990098714828491}},"branch_attrs":{"mutations":{"nuc":["T25171C"]}},"children":[{"name":"CM.11","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35566999999999993"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0179803928276123"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.11"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","T23019C","C25171T"],"S":["R346T","F486S"]},"labels":{"aa":"S: R346T, F486S","spike_mutations":"R346T, F486S"}}},{"name":"CM.12","node_attrs":{"div":102,"Nextclade_pango":{"value":"CM.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C2197T","C17163T","T20748C","C27928T","T28282C"],"ORF8":["T12I"]},"labels":{"aa":"ORF8: T12I"}}},{"name":"CM.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.29833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7566134796876517"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["T11522G","G23016A"],"S":["G485D"],"nsp6":["F184V"]},"labels":{"aa":"S: G485D; nsp6: F184V","spike_mutations":"G485D"}}},{"name":"CM.9","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.9"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"internal_2a9a","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{"nuc":["C6573T"],"nsp3":["S1285F"]},"labels":{"aa":"nsp3: S1285F"}},"children":[{"name":"CM.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"CM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.06344"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6802814026849654"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.42013692855835}},"branch_attrs":{"mutations":{}}},{"name":"CM.2.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"CM.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.2.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G16089A","T23019C","G29779T"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}}]},{"name":"NODE_0000692","node_attrs":{"div":99,"Nextclade_pango":{"value":"CM.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.268287658691406}},"branch_attrs":{"mutations":{"nuc":["T23019C","T23020C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"CM.7","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A19865G"],"nsp15":["N82S"]},"labels":{"aa":"nsp15: N82S"}}},{"name":"NODE_0000693","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}},"children":[{"name":"CM.7.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CM.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24425000000000008"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8703968752086992"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.854553699493408}},"branch_attrs":{"mutations":{}}},{"name":"CM.7.1.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CM.7.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9729599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9785485534494837"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.3.20.7.1.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C311T","G656A","G14500T","G22770A","C26801T"],"S":["R403K"],"nsp1":["L16F","A131T"],"nsp12":["V354L"]},"labels":{"aa":"S: R403K; nsp1: L16F, A131T; nsp12: V354L","spike_mutations":"R403K"}}}]}]}]}]}]},{"name":"NODE_0000694","node_attrs":{"div":72,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-2.128854513168335}},"branch_attrs":{"mutations":{"nuc":["C25416T"]}},"children":[{"name":"BA.2.17","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.17"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.112544536590576}},"branch_attrs":{"mutations":{"nuc":["G25909T","T29867A"],"ORF3a":["D173Y"]},"labels":{"aa":"ORF3a: D173Y"}}},{"name":"BA.2.21","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.21"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9177680015563965}},"branch_attrs":{"mutations":{"nuc":["G3482A","A8763G","G12160A"],"nsp3":["G255R"],"nsp4":["D70G"]},"labels":{"aa":"nsp3: G255R; nsp4: D70G"}}},{"name":"BA.2.37","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.37"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.100731372833252}},"branch_attrs":{"mutations":{"nuc":["G4527A"],"nsp3":["R603K"]},"labels":{"aa":"nsp3: R603K"}}},{"name":"BA.2.57","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.57"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.165760517120361}},"branch_attrs":{"mutations":{"nuc":["A6024G"],"nsp3":["Y1102C"]},"labels":{"aa":"nsp3: Y1102C"}}},{"name":"BA.2.66","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.66"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.677023887634277}},"branch_attrs":{"mutations":{"nuc":["C1204A","G3720A","C29625T"],"ORF10":["S23F"],"nsp2":["N133K"],"nsp3":["G334D"]},"labels":{"aa":"ORF10: S23F; nsp2: N133K; nsp3: G334D"}}},{"name":"BA.2.68","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.68"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.937255382537842}},"branch_attrs":{"mutations":{"nuc":["G13124A"],"nsp10":["G34R"]},"labels":{"aa":"nsp10: G34R"}}},{"name":"BA.2.74","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21698000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.33134042675697756"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.74"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.8886806964874268}},"branch_attrs":{"mutations":{"nuc":["A1T","C583T","C14925T","G22599C","C22916A","C26110T"],"ORF3a":["P240S"],"S":["R346T","L452M"]},"labels":{"aa":"ORF3a: P240S; S: R346T, L452M","spike_mutations":"R346T, L452M"}}},{"name":"BA.2.73","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.73"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0411696434021}},"branch_attrs":{"mutations":{"nuc":["C7124T","G22331A"],"S":["G257S"],"nsp3":["P1469S"]},"labels":{"aa":"S: G257S; nsp3: P1469S","spike_mutations":"G257S"}}},{"name":"BA.2.78","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.10556"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.78"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.664361953735352}},"branch_attrs":{"mutations":{"nuc":["A10323G","C22916A","G29628T","A29700G"],"ORF10":["R24L"],"S":["L452M"],"nsp5":["K90R"]},"labels":{"aa":"ORF10: R24L; S: L452M; nsp5: K90R","spike_mutations":"L452M"}}},{"name":"NODE_0000695","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.096076011657715}},"branch_attrs":{"mutations":{"nuc":["C16887T"]}},"children":[{"name":"BA.2.67","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.67"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T8023C","T13216G"],"nsp10":["D64E"]},"labels":{"aa":"nsp10: D64E"}}},{"name":"NODE_0000696","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.79"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{"nuc":["C16393T","A22305C","A22910G"],"S":["Y248S","N450D"],"nsp13":["P53S"]},"labels":{"aa":"S: Y248S, N450D; nsp13: P53S","spike_mutations":"Y248S, N450D"}},"children":[{"name":"BA.2.79","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.058580000000000014"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.719577789306641}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.79.1","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.79.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.058580000000000014"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.13308596942418072"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.79.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6312T","A17713G"],"nsp13":["I493V"],"nsp3":["T1198I"]},"labels":{"aa":"nsp13: I493V; nsp3: T1198I"}}}]}]},{"name":"NODE_0000697","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{"nuc":["T22304A","G22599C"],"S":["Y248N","R346T"]},"labels":{"aa":"S: Y248N, R346T","spike_mutations":"Y248N, R346T"}},"children":[{"name":"BA.2.76","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.6633100509643555}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000698","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.2.76"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C7528T","G19684T"],"nsp15":["V22L"]},"labels":{"aa":"nsp15: V22L"}},"children":[{"name":"BA.2.76.2","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.76.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.11142000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.20519369277613297"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G11453A","A22115C","C28603T"],"S":["N185H"],"nsp6":["A161T"]},"labels":{"aa":"S: N185H; nsp6: A161T","spike_mutations":"N185H"}}},{"name":"BA.2.76.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.76.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.18492"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.2640232066165751"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.76.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G5048A","C18555T","G22632A","T29233A"],"S":["R357K"],"nsp3":["G777S"]},"labels":{"aa":"S: R357K; nsp3: G777S","spike_mutations":"R357K"}}}]}]},{"name":"internal_ab43","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.4447851181030273}},"branch_attrs":{"mutations":{"nuc":["A22812C"],"S":["N417T"]},"labels":{"aa":"S: N417T","spike_mutations":"N417T"}},"children":[{"name":"BA.2.38","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.23107"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.05832824607945421"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.4447851181030273}},"branch_attrs":{"mutations":{}}},{"name":"internal_1a32","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.38.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{"nuc":["C21622T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","C21774T","C22786T","A22995G","G25352T"],"S":["H69-","V70-","S71F","K478R","V1264L"]},"labels":{"aa":"S: H69-, V70-, S71F, K478R, V1264L","spike_mutations":"H69-, V70-, S71F, K478R, V1264L"}},"children":[{"name":"BA.2.38.3","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.2.38.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.08445999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.07383293656037815"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.740930080413818}},"branch_attrs":{"mutations":{}}},{"name":"BH.1","node_attrs":{"div":82,"Nextclade_pango":{"value":"BH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.11188000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.370455061085298"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.3.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.580877304077148}},"branch_attrs":{"mutations":{"nuc":["T3905A","C10335G","T21992-","A21993-","T21994-","G22898A","T22917A"],"S":["Y144-","G446S","L452Q"],"nsp3":["F396I"],"nsp5":["A94G"]},"labels":{"aa":"S: Y144-, G446S, L452Q; nsp3: F396I; nsp5: A94G","spike_mutations":"Y144-, G446S, L452Q"}}}]},{"name":"NODE_0000701","node_attrs":{"div":73,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.987913131713867}},"branch_attrs":{"mutations":{"nuc":["G22894C"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.2.38.1","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.2.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.1"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.0862932205200195}},"branch_attrs":{"mutations":{"nuc":["T2C","G22225A","G22302A","A22305C","C22894T","G29779T"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}},{"name":"NODE_0000702","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.91279411315918}},"branch_attrs":{"mutations":{"nuc":["T7153C"]}},"children":[{"name":"BA.2.38.4","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.38.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.4"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.449609756469727}},"branch_attrs":{"mutations":{"nuc":["A22001G","A23636C"],"S":["K147E","I692L"]},"labels":{"aa":"S: K147E, I692L","spike_mutations":"K147E, I692L"}}},{"name":"BA.2.38.2","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.2.38.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07569000000000004"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3062371810866485"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.38.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-4.3194403648376465}},"branch_attrs":{"mutations":{"nuc":["C4893T","A11439G","C13329T","C17373T","T22032C"],"S":["F157S"],"nsp10":["T102I"],"nsp3":["T725I"],"nsp6":["N156S"]},"labels":{"aa":"S: F157S; nsp10: T102I; nsp3: T725I; nsp6: N156S","spike_mutations":"F157S"}}}]}]}]},{"name":"internal_096a","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.12"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{"nuc":["C11674T","C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}},"children":[{"name":"BA.2.12","node_attrs":{"div":74,"Nextclade_pango":{"value":"BA.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.000030000450009085718"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7861239910125732}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.12.2","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.12.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.07350000000000005"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.062348652344665065"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"BA.2.12.2"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.9585001468658447}},"branch_attrs":{"mutations":{"nuc":["C17586T","G22632A","A27578G"],"ORF7a":["Q62R"],"S":["R357K"]},"labels":{"aa":"ORF7a: Q62R; S: R357K","spike_mutations":"R357K"}}},{"name":"22C","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0579047203063965}},"branch_attrs":{"mutations":{"nuc":["T22917A"],"S":["L452Q"]},"labels":{"aa":"S: L452Q","clade":"22C","spike_mutations":"L452Q"}},"children":[{"name":"BA.2.12.1","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.2.12.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0579047203063965}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000705","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.2.12.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-1.8292839527130127}},"branch_attrs":{"mutations":{"nuc":["T15009C","C21721T"]}},"children":[{"name":"BG.1","node_attrs":{"div":80,"Nextclade_pango":{"value":"BG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.1"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C6070T","A6458G","G16207A"],"nsp12":["A923T"],"nsp3":["N1247D"]},"labels":{"aa":"nsp12: A923T; nsp3: N1247D"}}},{"name":"BG.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.2"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.0345396995544434}},"branch_attrs":{"mutations":{"nuc":["T11522G","C11575T","C16092T","G25352T","C25521T","G27798T","C27945T","C29118T"],"N":["T282I"],"ORF7b":["A15S"],"ORF8":["Q18*"],"S":["V1264L"],"nsp6":["F184V"]},"labels":{"aa":"N: T282I; ORF7b: A15S; ORF8: Q18*; S: V1264L; nsp6: F184V","spike_mutations":"V1264L"}}},{"name":"BG.3","node_attrs":{"div":79,"Nextclade_pango":{"value":"BG.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.3"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.567026138305664}},"branch_attrs":{"mutations":{"nuc":["A9164G","T13417C"],"nsp4":["T204A"]},"labels":{"aa":"nsp4: T204A"}}},{"name":"BG.5","node_attrs":{"div":79,"Nextclade_pango":{"value":"BG.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.5"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-3.8423192501068115}},"branch_attrs":{"mutations":{"nuc":["C44T","A12180G"],"nsp8":["D30G"]},"labels":{"aa":"nsp8: D30G"}}},{"name":"BG.6","node_attrs":{"div":80,"Nextclade_pango":{"value":"BG.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.6"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5284T","G13061A","G25166C"],"S":["E1202Q"],"nsp10":["V13I"]},"labels":{"aa":"S: E1202Q; nsp10: V13I","spike_mutations":"E1202Q"}}},{"name":"BG.4","node_attrs":{"div":82,"Nextclade_pango":{"value":"BG.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.4"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-4.367212772369385}},"branch_attrs":{"mutations":{"nuc":["G4510T","T7098C","C17977T","C28708T","C28758T"],"N":["P162L"],"nsp13":["L581F"],"nsp3":["I1460T"]},"labels":{"aa":"N: P162L; nsp13: L581F; nsp3: I1460T"}}},{"name":"BG.7","node_attrs":{"div":84,"Nextclade_pango":{"value":"BG.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.1269299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.1617041364563271"},"clade_display":{"value":"22C (BA.2.12.1)"},"partiallyAliased":{"value":"BA.2.12.1.7"},"clade_nextstrain":{"value":"22C"},"clade_membership":{"value":"22C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C904T","G2441A","T3324C","T5161A","T7226C","C18747T","C27630T"],"nsp2":["E546K"],"nsp3":["V202A","F814L","F1503L"]},"labels":{"aa":"nsp2: E546K; nsp3: V202A, F814L, F1503L"}}}]}]}]},{"name":"NODE_0000706","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.2.75"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{"nuc":["C3796T","C3927T","C4586T","C5183T","A12444G","G15451A","A22001G","T22016C","C22033A","A22190G","G22331A","G22577C","G22898A","T22942G","G23040A","A26275G"],"E":["T11A"],"S":["K147E","W152R","F157L","I210V","G257S","D339H","G446S","N460K","R493Q"],"nsp12":["G671S"],"nsp3":["S403L","P822S"],"nsp8":["N118S"]},"labels":{"aa":"E: T11A; S: K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q; nsp12: G671S; nsp3: S403L, P822S; nsp8: N118S","clade":"22D","spike_mutations":"K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q"}},"children":[{"name":"BA.2.75","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.2.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8620357513427734}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.75.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.499693393707275}},"branch_attrs":{"mutations":{"nuc":["A12140G"],"nsp8":["T17A"]},"labels":{"aa":"nsp8: T17A"}}},{"name":"BA.2.75.8","node_attrs":{"div":96,"Nextclade_pango":{"value":"BA.2.75.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04854"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","T1536C","G3774A","C3961T","A14963G","T18471C","T22917A","C23635T"],"S":["L452Q"],"nsp12":["K508R"],"nsp2":["V244A"],"nsp3":["R352H"]},"labels":{"aa":"S: L452Q; nsp12: K508R; nsp2: V244A; nsp3: R352H","spike_mutations":"L452Q"}}},{"name":"BA.2.75.7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.544774532318115}},"branch_attrs":{"mutations":{"nuc":["C44T","T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}}},{"name":"internal_2dc7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{"nuc":["G17679T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.9","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.736408233642578}},"branch_attrs":{"mutations":{}}},{"name":"CB.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81858"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.9.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.514627933502197}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}}}]},{"name":"BA2754","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.472270488739014}},"branch_attrs":{"mutations":{"nuc":["C44T","C9532T","G19962T","T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BA.2.75.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.2.75.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.13451"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.39024840374521963"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.472270488739014}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000709","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{"nuc":["T44C","C21054T","G22599C","T23018A"],"S":["R346T","F486I"]},"labels":{"aa":"S: R346T, F486I","spike_mutations":"R346T, F486I"}},"children":[{"name":"BR.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7472099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.502371311187744}},"branch_attrs":{"mutations":{}}},{"name":"BR.2.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7472099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.378986358642578}},"branch_attrs":{"mutations":{"nuc":["C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}}}]},{"name":"internal_b66e","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.870347499847412}},"branch_attrs":{"mutations":{"nuc":["G8602A"]}},"children":[{"name":"BR.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.24593"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5588825437629772"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["A13498G","G22599C"],"S":["R346T"],"nsp12":["T20A"]},"labels":{"aa":"S: R346T; nsp12: T20A","spike_mutations":"R346T"}}},{"name":"NODE_0000711","node_attrs":{"div":94,"Nextclade_pango":{"value":"BR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{"nuc":["A22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}},"children":[{"name":"BR.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9449499999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497799396514893}},"branch_attrs":{"mutations":{}}},{"name":"BR.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.12575999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7451886007636047"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.81504487991333}},"branch_attrs":{"mutations":{"nuc":["T20605C","T23019C","T27071G"],"S":["F486S"],"nsp15":["F329L"]},"labels":{"aa":"S: F486S; nsp15: F329L","spike_mutations":"F486S"}}},{"name":"BR.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9449499999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21724A","A22481T","T23431C","C23683T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["T307S"]},"labels":{"aa":"S: T307S","spike_mutations":"T307S"}}}]},{"name":"NODE_0000712","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.456613540649414}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BR.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"BR.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.10514"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5013910005227346"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22898G","C25487T"],"ORF3a":["T32I"],"S":["S446G"]},"labels":{"aa":"ORF3a: T32I; S: S446G","spike_mutations":"S446G"}}},{"name":"NODE_0000713","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A12306G","A23283T","A26612T"],"S":["D574V"],"nsp8":["K72R"]},"labels":{"aa":"S: D574V; nsp8: K72R","spike_mutations":"D574V"}},"children":[{"name":"BR.5","node_attrs":{"div":97,"Nextclade_pango":{"value":"BR.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03573"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"BR.5.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"BR.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03573"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5509033720256986"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.4.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["G6352T","C18032T","A20289G","G25494C"],"nsp13":["T599I"],"nsp3":["K1211N"]},"labels":{"aa":"nsp13: T599I; nsp3: K1211N"}}}]}]}]}]},{"name":"NODE_0000714","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{"nuc":["A23283T"],"S":["D574V"]},"labels":{"aa":"S: D574V","spike_mutations":"D574V"}},"children":[{"name":"BA.2.75.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.100642204284668}},"branch_attrs":{"mutations":{}}},{"name":"BL.4","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C11224T","A22720G","C27527T"],"ORF7a":["P45L"]},"labels":{"aa":"ORF7a: P45L"}}},{"name":"NODE_0000715","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.2.75.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.210728645324707}},"branch_attrs":{"mutations":{"nuc":["G204A","A26612T"]}},"children":[{"name":"BL.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.785837650299072}},"branch_attrs":{"mutations":{"nuc":["C8318T"],"nsp3":["P1867S"]},"labels":{"aa":"nsp3: P1867S"}}},{"name":"BL.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BL.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16854"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G18443T","A22600T","C27903T","C28744T","G29179C","C29375T","G29540T"],"N":["P368S"],"ORF8":["L4F"],"S":["R346S"],"nsp14":["R135I"]},"labels":{"aa":"N: P368S; ORF8: L4F; S: R346S; nsp14: R135I","spike_mutations":"R346S"}}},{"name":"NODE_0000716","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.043233871459961}},"branch_attrs":{"mutations":{"nuc":["C15277T","A22106G"],"S":["K182E"],"nsp12":["H613Y"]},"labels":{"aa":"S: K182E; nsp12: H613Y","spike_mutations":"K182E"}}},{"name":"BL.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BL.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.590982913970947}},"branch_attrs":{"mutations":{}}}]}]},{"name":"NODE_0000717","node_attrs":{"div":90,"Nextclade_pango":{"value":"BL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BL.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.178386211395264}},"branch_attrs":{"mutations":{}}},{"name":"BL.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10336T","G23402A","A29700G"],"S":["G614S"]},"labels":{"aa":"S: G614S","spike_mutations":"G614S"}}},{"name":"BL.1.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G22344A","G22484T","T25476C","A25506G"],"S":["G261D","V308L"]},"labels":{"aa":"S: G261D, V308L","spike_mutations":"G261D, V308L"}}},{"name":"BL.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.19193"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267463684082031}},"branch_attrs":{"mutations":{"nuc":["C21302T","C21304A","G21305A","T23030C","T29867A"],"S":["F490L"],"nsp16":["P215L","R216N"]},"labels":{"aa":"S: F490L; nsp16: P215L, R216N","spike_mutations":"F490L"}}},{"name":"BL.1.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BL.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.3464399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5934256167649397"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C4456T","T6086C","G17756A","T23030G","T27846C"],"ORF7b":["S31P"],"S":["F490V"],"nsp13":["R507K"]},"labels":{"aa":"ORF7b: S31P; S: F490V; nsp13: R507K","spike_mutations":"F490V"}}},{"name":"BL.1.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BL.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.56756"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6011952983295785"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.973635673522949}},"branch_attrs":{"mutations":{"nuc":["C44T","C9592T","C22986T","C22993T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BL.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"BL.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.11979"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5544855553668998"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.1.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C44T","C3653T","C7564T","T13527C","T22896C","C25276A","C25339T","C29640T"],"ORF10":["A28V"],"S":["V445A"],"nsp3":["L312F"]},"labels":{"aa":"ORF10: A28V; S: V445A; nsp3: L312F","spike_mutations":"V445A"}}}]}]},{"name":"internal_94e7","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.681194305419922}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.2.75.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.2.75.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.681194305419922}},"branch_attrs":{"mutations":{}}},{"name":"internal_c7e6","node_attrs":{"div":91,"Nextclade_pango":{"value":"BY.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BY.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.275525093078613}},"branch_attrs":{"mutations":{}}},{"name":"internal_1967","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","spike_mutations":"L452R"}},"children":[{"name":"BY.1.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BY.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1034G","A8577G","G8999T","A22115G","A22182G"],"S":["N185D","H207R"],"nsp2":["I77V"],"nsp4":["K8R","A149S"]},"labels":{"aa":"S: N185D, H207R; nsp2: I77V; nsp4: K8R, A149S","spike_mutations":"N185D, H207R"}}},{"name":"BY.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.096330165863037}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_147e","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{"nuc":["G26828T"]}},"children":[{"name":"BY.1.2.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BY.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41646999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G370T","G567T","G12797A","T23042C","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["S494P"],"nsp1":["G101V"],"nsp9":["G38S"]},"labels":{"aa":"S: S494P; nsp1: G101V; nsp9: G38S","spike_mutations":"S494P"}}},{"name":"BY.1.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BY.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.6.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.546011447906494}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_a555","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{"nuc":["T44C","C5192T","G25157A"],"S":["D1199N"]},"labels":{"aa":"S: D1199N","spike_mutations":"D1199N"}},"children":[{"name":"BA.2.75.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.2.75.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7263596057891846}},"branch_attrs":{"mutations":{}}},{"name":"CA.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C2925T","C6336T","T22917G","C23373T","G25522A"],"ORF3a":["G44R"],"S":["L452R","T604I"],"nsp3":["S69F","S1206L"]},"labels":{"aa":"ORF3a: G44R; S: L452R, T604I; nsp3: S69F, S1206L","spike_mutations":"L452R, T604I"}}},{"name":"CA.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.41646999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.716528415679932}},"branch_attrs":{"mutations":{"nuc":["C44T","T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CA.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"CA.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["G943A","C11591A","T17505C","T22917G"],"S":["L452R"],"nsp6":["L207I"]},"labels":{"aa":"S: L452R; nsp6: L207I","spike_mutations":"L452R"}}},{"name":"CA.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T851C"],"nsp2":["Y16H"]},"labels":{"aa":"nsp2: Y16H"}}},{"name":"CA.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"CA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2245T","C22341A","G23401T","T27104C"],"S":["A260D","Q613H"]},"labels":{"aa":"S: A260D, Q613H","spike_mutations":"A260D, Q613H"}}},{"name":"CA.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G1820A","G3250T","C7431T","T23018C","C25378T"],"S":["S486P"],"nsp2":["G339S"],"nsp3":["E177D","S1571L"]},"labels":{"aa":"S: S486P; nsp2: G339S; nsp3: E177D, S1571L","spike_mutations":"S486P"}}},{"name":"internal_80b8","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{"nuc":["G28576C"],"N":["M101I"],"ORF9b":["*98S"]},"labels":{"aa":"N: M101I; ORF9b: *98S"}},"children":[{"name":"CA.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CA.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.022957801818848}},"branch_attrs":{"mutations":{}}},{"name":"CA.3.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CA.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2371799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.580175876617432}},"branch_attrs":{"mutations":{"nuc":["T22384C","A22893T","T22917G","T28672A"],"S":["K444M","L452R"]},"labels":{"aa":"S: K444M, L452R","spike_mutations":"K444M, L452R"}}}]}]}]}]},{"name":"internal_75e5","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.0969929695129395}},"branch_attrs":{"mutations":{"nuc":["A22629C"],"S":["K356T"]},"labels":{"aa":"S: K356T","spike_mutations":"K356T"}},"children":[{"name":"BA.2.75.5","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.0969929695129395}},"branch_attrs":{"mutations":{}}},{"name":"BN.4","node_attrs":{"div":91,"Nextclade_pango":{"value":"BN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14197"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78438138961792}},"branch_attrs":{"mutations":{"nuc":["G1440A","T23031C"],"S":["F490S"],"nsp2":["G212D"]},"labels":{"aa":"S: F490S; nsp2: G212D","spike_mutations":"F490S"}}},{"name":"BN.5","node_attrs":{"div":90,"Nextclade_pango":{"value":"BN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.53290319442749}},"branch_attrs":{"mutations":{"nuc":["G9128A"],"nsp4":["V192M"]},"labels":{"aa":"nsp4: V192M"}}},{"name":"BN.6","node_attrs":{"div":91,"Nextclade_pango":{"value":"BN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.629093170166016}},"branch_attrs":{"mutations":{"nuc":["A1G","A12140G"],"nsp8":["T17A"]},"labels":{"aa":"nsp8: T17A"}}},{"name":"internal_ece3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{"nuc":["C1093T","G1440A","A1964G","C21077T","A22910G"],"S":["N450D"],"nsp16":["T140I"],"nsp2":["G212D","I387V"]},"labels":{"aa":"S: N450D; nsp16: T140I; nsp2: G212D, I387V","spike_mutations":"N450D"}},"children":[{"name":"BN.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.11385"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5060716304521155"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.488798141479492}},"branch_attrs":{"mutations":{}}},{"name":"BN.3.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.653690335850791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.9134328365325928}},"branch_attrs":{"mutations":{"nuc":["A5844G","C8597T","T23031C"],"S":["F490S"],"nsp3":["K1042R"],"nsp4":["L15F"]},"labels":{"aa":"S: F490S; nsp3: K1042R; nsp4: L15F","spike_mutations":"F490S"}}}]},{"name":"internal_40f9","node_attrs":{"div":92,"Nextclade_pango":{"value":"BN.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{"nuc":["C44T","A28761T","G29868C"],"N":["Q163L"]},"labels":{"aa":"N: Q163L"}},"children":[{"name":"BN.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1724299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.38697362521288264"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.227936267852783}},"branch_attrs":{"mutations":{}}},{"name":"BN.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14197"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5511388309290768"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21707T","T23031C"],"S":["H49Y","F490S"]},"labels":{"aa":"S: H49Y, F490S","spike_mutations":"H49Y, F490S"}}}]},{"name":"NODE_0000727","node_attrs":{"div":93,"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{"nuc":["A1T","C20235T","G22599C","T23031C"],"S":["R346T","F490S"]},"labels":{"aa":"S: R346T, F490S","spike_mutations":"R346T, F490S"}},"children":[{"name":"BN.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.7420108318328857}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.216355323791504}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BN.1.11","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.11"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2462T","A3829G","C6701T","C7471T","C22088T","G24368C","C27649T"],"S":["L176F","D936H"],"nsp3":["L1328F"]},"labels":{"aa":"S: L176F, D936H; nsp3: L1328F","spike_mutations":"L176F, D936H"}}},{"name":"BN.1.7","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.24932336807251}},"branch_attrs":{"mutations":{"nuc":["T22092C","A22194-","T22195-","T22196-","C22858T","C24863T"],"S":["M177T","V210-","N211V","L212I","H1101Y"]},"labels":{"aa":"S: M177T, V210-, N211V, L212I, H1101Y","spike_mutations":"M177T, V210-, N211V, L212I, H1101Y"}}},{"name":"BN.1.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5340599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9193315170816834"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C13665T","T17166G","T21628C","C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"BN.1.6","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.977735996246338}},"branch_attrs":{"mutations":{"nuc":["G24977C","G29072T"],"N":["A267S"],"S":["D1139H"]},"labels":{"aa":"N: A267S; S: D1139H","spike_mutations":"D1139H"}}},{"name":"NODE_0000728","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["T23042C","C28585T"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}},"children":[{"name":"BN.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.2021600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.2021600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7420698342212109"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["A22115G","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"NODE_0000729","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{"nuc":["C6573T","G20774A"],"nsp16":["G39D"],"nsp3":["S1285F"]},"labels":{"aa":"nsp16: G39D; nsp3: S1285F"}},"children":[{"name":"BN.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.009160041809082}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000730","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.842319011688232}},"branch_attrs":{"mutations":{"nuc":["C4901T","C5986T"]}},"children":[{"name":"BN.1.5.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"BN.1.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.31233"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7815531080803261"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","T23102A"],"S":["S514T"]},"labels":{"aa":"S: S514T","spike_mutations":"S514T"}}},{"name":"BN.1.5.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.1331"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7470314258752732"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.5.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T23005A"],"S":["N481K"]},"labels":{"aa":"S: N481K","spike_mutations":"N481K"}}}]}]},{"name":"NODE_0000731","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{"nuc":["T27501C"]}},"children":[{"name":"BN.1.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.890091896057129}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.4.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":13},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.086867332458496}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C8782T","G16912T","G18634A"],"nsp1":["M85-"],"nsp13":["V226L"],"nsp14":["V199M"]},"labels":{"aa":"nsp1: M85-; nsp13: V226L; nsp14: V199M"}}},{"name":"BN.1.4.5","node_attrs":{"div":101,"Nextclade_pango":{"value":"BN.1.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C1348T","T10057C","C10125T","G15921T","C18252T","T20583C","T23875C"],"nsp5":["T24I"]},"labels":{"aa":"nsp5: T24I"}}},{"name":"NODE_0000732","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["G10364A","C14318T"],"nsp12":["T293I"],"nsp5":["V104I"]},"labels":{"aa":"nsp12: T293I; nsp5: V104I"}},"children":[{"name":"BN.1.4.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"BN.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A10132T","T11773C","C12789T","G22344T","C23595T","T24850C","T25502C","C26110T","A28117G","G29764A"],"ORF3a":["I37T","P240S"],"ORF8":["D75G"],"S":["G261V","T678I"],"nsp9":["T35I"]},"labels":{"aa":"ORF3a: I37T, P240S; ORF8: D75G; S: G261V, T678I; nsp9: T35I","spike_mutations":"G261V, T678I"}}},{"name":"BN.1.4.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T3106C","C3551A"],"nsp3":["P278T"]},"labels":{"aa":"nsp3: P278T"}}},{"name":"BN.1.4.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C19763T","A21137G","C24899A","C26611T"],"M":["T30I"],"S":["Q1113K"],"nsp15":["T48I"],"nsp16":["K160R"]},"labels":{"aa":"M: T30I; S: Q1113K; nsp15: T48I; nsp16: K160R","spike_mutations":"Q1113K"}}}]}]},{"name":"NODE_0000733","node_attrs":{"div":94,"Nextclade_pango":{"value":"BN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.13617467880249}},"branch_attrs":{"mutations":{"nuc":["T11515C"]}},"children":[{"name":"BN.1.9","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.220160961151123}},"branch_attrs":{"mutations":{"nuc":["G26416T"],"E":["V58F"]},"labels":{"aa":"E: V58F"}}},{"name":"NODE_0000734","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{"nuc":["A26459G"],"E":["D72G"]},"labels":{"aa":"E: D72G"}},"children":[{"name":"BN.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.5018537044525146}},"branch_attrs":{"mutations":{}}},{"name":"BN.1.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.21326"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7326886306518271"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.036893367767334}},"branch_attrs":{"mutations":{"nuc":["C1915T","A18479T","C22971A"],"S":["T470N"],"nsp14":["K147I"]},"labels":{"aa":"S: T470N; nsp14: K147I","spike_mutations":"T470N"}}},{"name":"BN.1.2.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.775951862335205}},"branch_attrs":{"mutations":{"nuc":["C29546T"]}}},{"name":"BN.1.2.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C3241T","C16833T","G22225A"]}}},{"name":"BN.1.2.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.376992702484131}},"branch_attrs":{"mutations":{"nuc":["G18703C"],"nsp14":["D222H"]},"labels":{"aa":"nsp14: D222H"}}},{"name":"BN.1.2.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","A28296G","G28375T"],"N":["N8S"],"ORF9b":["I5V","G31V"]},"labels":{"aa":"N: N8S; ORF9b: I5V, G31V"}}},{"name":"BN.1.2.6","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["C15924T","G17443T"],"nsp13":["A403S"]},"labels":{"aa":"nsp13: A403S"}}},{"name":"BN.1.2.8","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T4744C","T23671G","C28651T"],"S":["N703K"]},"labels":{"aa":"S: N703K","spike_mutations":"N703K"}}},{"name":"NODE_0000735","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{"nuc":["C1471T"]}},"children":[{"name":"BN.1.2.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.163093090057373}},"branch_attrs":{"mutations":{}}},{"name":"FR.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"FR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.3705925941467285}},"branch_attrs":{"mutations":{"nuc":["T6023C","T18863G","A20364G","C29272T"],"nsp14":["I275S"],"nsp3":["Y1102H"]},"labels":{"aa":"nsp14: I275S; nsp3: Y1102H"}}},{"name":"NODE_0000736","node_attrs":{"div":101,"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{"nuc":["C337T","C1513T","A22121G","C25572T","C29370T"],"N":["T366I"],"S":["K187E"]},"labels":{"aa":"N: T366I; S: K187E","spike_mutations":"K187E"}},"children":[{"name":"FR.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.757643222808838}},"branch_attrs":{"mutations":{}}},{"name":"FR.1.2","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","T14727C","A16984G","C20703T","G22131T","C22858T"],"S":["R190M"],"nsp13":["T250A"]},"labels":{"aa":"S: R190M; nsp13: T250A","spike_mutations":"R190M"}}},{"name":"FR.1.5","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G611A","C6990T","T8719A","C11344T","T12477C"],"nsp1":["V116M"],"nsp3":["S1424F"],"nsp8":["M129T"]},"labels":{"aa":"nsp1: V116M; nsp3: S1424F; nsp8: M129T"}}},{"name":"FR.1.3","node_attrs":{"div":109,"Nextclade_pango":{"value":"FR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C203T","C882T","C14097T","C14599T","C15017T","C25603T","T28019C","G28374A"],"N":["-31E","G34-"],"ORF9b":["G31R"],"nsp12":["A526V"],"nsp2":["A26V"]},"labels":{"aa":"N: -31E, G34-; ORF9b: G31R; nsp12: A526V; nsp2: A26V"}}},{"name":"NODE_0000737","node_attrs":{"div":105,"Nextclade_pango":{"value":"FR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","T2372C","C7318T","T14961C"],"nsp2":["L113F"]},"labels":{"aa":"nsp2: L113F"}},"children":[{"name":"FR.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["A4T","C21807A"],"S":["P82H"]},"labels":{"aa":"S: P82H","spike_mutations":"P82H"}}},{"name":"FR.1.4","node_attrs":{"div":107,"Nextclade_pango":{"value":"FR.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.2.3.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A3715G","C15960T"]}}}]}]}]}]}]},{"name":"internal_57ac","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{"nuc":["G11146T","C26078T"],"ORF3a":["T229I"],"nsp6":["M58I"]},"labels":{"aa":"ORF3a: T229I; nsp6: M58I"}},"children":[{"name":"BN.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.563671112060547}},"branch_attrs":{"mutations":{}}},{"name":"internal_T4435C","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.497981071472168}},"branch_attrs":{"mutations":{"nuc":["T4435C"]}},"children":[{"name":"BN.1.3.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.629613876342773}},"branch_attrs":{"mutations":{"nuc":["T12871C","G22001C","G28090-","T28091-","T28092-","C28093-","T28094-","A28095-"],"ORF8":["G66-","S67-","K68E"],"S":["E147Q"]},"labels":{"aa":"ORF8: G66-, S67-, K68E; S: E147Q","spike_mutations":"E147Q"}}},{"name":"BN.1.3.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.060054302215576}},"branch_attrs":{"mutations":{"nuc":["C44T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_1ee3","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{"nuc":["C3787T","T10721C"],"nsp5":["F223L"]},"labels":{"aa":"nsp5: F223L"}},"children":[{"name":"BN.1.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.821800470352173}},"branch_attrs":{"mutations":{}}},{"name":"DS.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"DS.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["C25521T","G26153T"],"ORF3a":["G254V"]},"labels":{"aa":"ORF3a: G254V"}}},{"name":"DS.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"DS.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["C18115T","C23277T","C26151T","C29627T"],"ORF10":["R24C"],"S":["T572I"],"nsp14":["H26Y"]},"labels":{"aa":"ORF10: R24C; S: T572I; nsp14: H26Y","spike_mutations":"T572I"}}},{"name":"DS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"DS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.16291"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0513083167390975"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["T7174C","G22770A","T23019C"],"S":["R403K","F486S"]},"labels":{"aa":"S: R403K, F486S","spike_mutations":"R403K, F486S"}}}]}]},{"name":"internal_C593T","node_attrs":{"div":96,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.6493959426879883}},"branch_attrs":{"mutations":{"nuc":["C593T"],"nsp1":["H110Y"]},"labels":{"aa":"nsp1: H110Y"}},"children":[{"name":"BN.1.3.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.10"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.8560333251953125}},"branch_attrs":{"mutations":{"nuc":["A6018G","C13608T"],"nsp3":["Q1100R"]},"labels":{"aa":"nsp3: Q1100R"}}},{"name":"BN.1.3.12","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.12"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.11445951461792}},"branch_attrs":{"mutations":{"nuc":["C14358T","T22672C"]}}},{"name":"BN.1.3.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["T18815G","T22896C"],"S":["V445A"],"nsp14":["L259R"]},"labels":{"aa":"S: V445A; nsp14: L259R","spike_mutations":"V445A"}}},{"name":"BN.1.3.9","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.9"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.5760722160339355}},"branch_attrs":{"mutations":{"nuc":["G21809T"],"S":["V83F"]},"labels":{"aa":"S: V83F","spike_mutations":"V83F"}}},{"name":"internal_ab5b","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["G24977C"],"S":["D1139H"]},"labels":{"aa":"S: D1139H","spike_mutations":"D1139H"}},"children":[{"name":"BN.1.3.8","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"EJ.3","node_attrs":{"div":100,"Nextclade_pango":{"value":"EJ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2509T","C3241T","C17004T"]}}},{"name":"EJ.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.0823516845703125}},"branch_attrs":{"mutations":{"nuc":["A25235G"],"S":["I1225V"]},"labels":{"aa":"S: I1225V","spike_mutations":"I1225V"}}},{"name":"EJ.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"EJ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.8.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"nsp10":["T102I"]},"labels":{"aa":"nsp10: T102I"}}}]},{"name":"internal_f14e","node_attrs":{"div":97,"Nextclade_pango":{"value":"BN.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.269749402999878}},"branch_attrs":{"mutations":{"nuc":["C7390A"]}},"children":[{"name":"BN.1.3.11","node_attrs":{"div":102,"Nextclade_pango":{"value":"BN.1.3.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.11"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1968T","G3896T","T13339C","T22861C","C29167T"],"nsp2":["T388I"],"nsp3":["V393F"]},"labels":{"aa":"nsp2: T388I; nsp3: V393F"}}},{"name":"BN.1.3.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"BN.1.3.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08629"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8610252871641654"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.13"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C3817T","C17818T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BN.1.3.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.880107879638672}},"branch_attrs":{"mutations":{"nuc":["T27878G"],"ORF7b":["C41W"]},"labels":{"aa":"ORF7b: C41W"}}},{"name":"BN.1.3.6","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-3.791741371154785}},"branch_attrs":{"mutations":{"nuc":["G27043A"],"M":["R174Q"]},"labels":{"aa":"M: R174Q"}}},{"name":"BN.1.3.7","node_attrs":{"div":98,"Nextclade_pango":{"value":"BN.1.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.25339"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7137312413663139"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.5.1.3.7"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.041549205780029}},"branch_attrs":{"mutations":{"nuc":["C4551T"],"nsp3":["T611I"]},"labels":{"aa":"nsp3: T611I"}}}]}]}]}]}]},{"name":"internal_4ad3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{"nuc":["G18583A"],"nsp14":["V182I"]},"labels":{"aa":"nsp14: V182I"}},"children":[{"name":"BA.2.75.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.2.75.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.307504177093506}},"branch_attrs":{"mutations":{}}},{"name":"BM.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.3020243644714355}},"branch_attrs":{"mutations":{"nuc":["C176T","C18421T"],"nsp14":["P128S"]},"labels":{"aa":"nsp14: P128S"}}},{"name":"BM.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15852"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.03087854385376}},"branch_attrs":{"mutations":{"nuc":["C44T","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"BM.6","node_attrs":{"div":96,"Nextclade_pango":{"value":"BM.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15852"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3112478426618121"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.6"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4G","T5218C","A8667G","G21786T","T22926C","C27804T","C28610A"],"N":["L113I"],"S":["G75V","L455S"],"nsp4":["D38G"]},"labels":{"aa":"N: L113I; S: G75V, L455S; nsp4: D38G","spike_mutations":"G75V, L455S"}}},{"name":"NODE_0000745","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.28689"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.43632774842967204"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.05271577835083}},"branch_attrs":{"mutations":{}}},{"name":"BM.2.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BM.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.26994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5272935807019111"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2A","T3A","A4T","C2536T","C5822T","T6148G","C15951T","T22926C"],"S":["L455S"],"nsp3":["L1035F"]},"labels":{"aa":"S: L455S; nsp3: L1035F","spike_mutations":"L455S"}}},{"name":"NODE_0000746","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.549932956695557}},"branch_attrs":{"mutations":{"nuc":["T23018G"],"S":["F486V"]},"labels":{"aa":"S: F486V","spike_mutations":"F486V"}},"children":[{"name":"BM.2.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.78817"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.180056571960449}},"branch_attrs":{"mutations":{"nuc":["C44T","A21851C","G23018A"],"S":["K97Q","V486I"]},"labels":{"aa":"S: K97Q, V486I","spike_mutations":"K97Q, V486I"}}},{"name":"BM.2.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.81858"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.2.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21T","T9628C","C21928T","A29683-"]}}}]}]},{"name":"internal_8fe9","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.426807403564453}},"branch_attrs":{"mutations":{}}},{"name":"internal_1320","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.1.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.78330659866333}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000749","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.458259105682373}},"branch_attrs":{"mutations":{"nuc":["C16887T","G27798T"],"ORF7b":["A15S"]},"labels":{"aa":"ORF7b: A15S"}},"children":[{"name":"BM.1.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BM.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T145C","C635T","C1392T","T8855C","C24210T","C24378T","C24797A"],"S":["T883I","S939F","P1079T"],"nsp1":["R124C"],"nsp2":["S196L"],"nsp4":["F101L"]},"labels":{"aa":"S: T883I, S939F, P1079T; nsp1: R124C; nsp2: S196L; nsp4: F101L","spike_mutations":"T883I, S939F, P1079T"}}},{"name":"BM.1.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"BM.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.5"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.992039680480957}},"branch_attrs":{"mutations":{"nuc":["A22116G","T22917G"],"S":["N185S","L452R"]},"labels":{"aa":"S: N185S, L452R","spike_mutations":"N185S, L452R"}}}]},{"name":"internal_f6c6","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{"nuc":["G261A","T23031C"],"S":["F490S"]},"labels":{"aa":"S: F490S","spike_mutations":"F490S"}},"children":[{"name":"BM.1.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.43724"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.267230987548828}},"branch_attrs":{"mutations":{}}},{"name":"internal_a785","node_attrs":{"div":95,"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{"nuc":["C44T","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CJ.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.273774147033691}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000752","node_attrs":{"div":96,"Nextclade_pango":{"value":"CJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["A5006G"],"nsp3":["T763A"]},"labels":{"aa":"nsp3: T763A"}},"children":[{"name":"CJ.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.87567"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9457248359372292"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.215351581573486}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CJ.1.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.262165069580078}},"branch_attrs":{"mutations":{"nuc":["C8090T"],"nsp3":["L1791F"]},"labels":{"aa":"nsp3: L1791F"}}}]},{"name":"NODE_0000753","node_attrs":{"div":98,"Nextclade_pango":{"value":"CJ.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A261G","G4960A","C14790T"]}},"children":[{"name":"CJ.1.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"CJ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{}}},{"name":"CJ.1.3.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CJ.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T11618C","G24368C"],"S":["D936H"],"nsp6":["F216L"]},"labels":{"aa":"S: D936H; nsp6: F216L","spike_mutations":"D936H"}}},{"name":"CJ.1.3.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"CJ.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04277"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7836579797060339"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C2197T","C4582T","G10997A","T11737C","C11962T","C14649T","C22202A"],"S":["R214S"],"nsp6":["G9S"]},"labels":{"aa":"S: R214S; nsp6: G9S","spike_mutations":"R214S"}}}]}]}]},{"name":"NODE_0000754","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.456503391265869}},"branch_attrs":{"mutations":{"nuc":["C3130T"]}},"children":[{"name":"NODE_0000755","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{"nuc":["C15183T","C29580T"],"ORF10":["A8V"]},"labels":{"aa":"ORF10: A8V"}},"children":[{"name":"BM.1.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BM.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.035793304443359}},"branch_attrs":{"mutations":{}}},{"name":"CV.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1806A","A16907G","T23018C"],"S":["S486P"],"nsp13":["Y224C"],"nsp2":["G334E"]},"labels":{"aa":"S: S486P; nsp13: Y224C; nsp2: G334E","spike_mutations":"S486P"}}},{"name":"CV.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42674000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.752146957006636"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A2473T","T4914C","T6148A","T10249C","T22917G"],"S":["L452R"],"nsp3":["V732A"]},"labels":{"aa":"S: L452R; nsp3: V732A","spike_mutations":"L452R"}}}]},{"name":"NODE_0000756","node_attrs":{"div":97,"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C912A","A2151C","A22629C","C23277T","G29527A"],"S":["K356T","T572I"],"nsp2":["S36Y","D449A"]},"labels":{"aa":"S: K356T, T572I; nsp2: S36Y, D449A","spike_mutations":"K356T, T572I"}},"children":[{"name":"BM.1.1.4","node_attrs":{"div":97,"Nextclade_pango":{"value":"BM.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.46466000000000013"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000757","node_attrs":{"div":99,"Nextclade_pango":{"value":"BM.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T3037C","C14805T"]}},"children":[{"name":"EP.2","node_attrs":{"div":104,"Nextclade_pango":{"value":"EP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.46466000000000013"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.760602270328532"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7735T","T19896C","C25002T","C27513T","G28907A"],"N":["G212S"],"S":["S1147L"]},"labels":{"aa":"N: G212S; S: S1147L","spike_mutations":"S1147L"}}},{"name":"NODE_0000758","node_attrs":{"div":105,"Nextclade_pango":{"value":"EP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1102T","C7945T","A9343G","G20683A","T22917G","C29200T"],"S":["L452R"],"nsp16":["V9I"]},"labels":{"aa":"S: L452R; nsp16: V9I","spike_mutations":"L452R"}},"children":[{"name":"EP.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"EP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000759","node_attrs":{"div":109,"Nextclade_pango":{"value":"EP.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C12623T","C17010T","C27855T","A27947T"],"ORF8":["Q18H"],"nsp8":["P178S"]},"labels":{"aa":"ORF8: Q18H; nsp8: P178S"}},"children":[{"name":"EP.1.1","node_attrs":{"div":109,"Nextclade_pango":{"value":"EP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"EP.1.1.1","node_attrs":{"div":118,"Nextclade_pango":{"value":"EP.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.42369999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8912656658423938"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.1.1.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G6802A","C16887T","T18231C","C21627A","C21789T","A24578G","C25006T","C28603T","G29628A"],"ORF10":["R24H"],"S":["T22N","T76I","T1006A"]},"labels":{"aa":"ORF10: R24H; S: T22N, T76I, T1006A","spike_mutations":"T22N, T76I, T1006A"}}}]}]}]}]}]}]}]},{"name":"internal_9cd1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{"nuc":["C3857A"],"nsp3":["Q380K"]},"labels":{"aa":"nsp3: Q380K"}},"children":[{"name":"BM.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BM.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.17547"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.23333202257863933"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.5365495681762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_9ced","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{"nuc":["T23019C"],"S":["F486S"]},"labels":{"aa":"S: F486S","spike_mutations":"F486S"}},"children":[{"name":"BM.4.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BM.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35628"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3762887593808791"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.628498077392578}},"branch_attrs":{"mutations":{}}},{"name":"internal_635f","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BM.4.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BM.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-4.506659984588623}},"branch_attrs":{"mutations":{}}},{"name":"CH.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4677"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.2"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.80463981628418}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"NODE_0000763","node_attrs":{"div":93,"Nextclade_pango":{"value":"BM.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.852805137634277}},"branch_attrs":{"mutations":{"nuc":["A20741G"],"nsp16":["Q28R"]},"labels":{"aa":"nsp16: Q28R"}},"children":[{"name":"internal_e4db","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T13090C","T14565A","T23018C"],"S":["S486P"]},"labels":{"aa":"S: S486P","spike_mutations":"S486P"}},"children":[{"name":"CH.3.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.0219999999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6604462442172514"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"CH.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.07323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6094925309137131"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.3"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_b60a","node_attrs":{"div":94,"Nextclade_pango":{"value":"CH.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"CH.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"CH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36891999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7685109779549473"},"clade_display":{"value":"22D (BA.2.75)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1"},"clade_nextstrain":{"value":"22D"},"clade_membership":{"value":"22D"},"placement_prior":{"value":-5.9683122634887695}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000766","node_attrs":{"div":95,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{"nuc":["T22917G"],"S":["L452R"]},"labels":{"aa":"S: L452R","clade":"23C","spike_mutations":"L452R"}},"children":[{"name":"CH.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CH.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.056298732757568}},"branch_attrs":{"mutations":{}}},{"name":"CH.1.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.27"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C1878T"],"nsp2":["S358L"]},"labels":{"aa":"nsp2: S358L"}}},{"name":"CH.1.1.7","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.08756160736084}},"branch_attrs":{"mutations":{"nuc":["T693G"],"nsp1":["F143C"]},"labels":{"aa":"nsp1: F143C"}}},{"name":"NODE_0000767","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C11674T"]}},"children":[{"name":"CH.1.1.18","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.18"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2015G","C3486T","A9154G","A22122C","C23086T","C25710T","C28737T"],"N":["A155V"],"S":["K187T"],"nsp2":["M404V"],"nsp3":["A256V"]},"labels":{"aa":"N: A155V; S: K187T; nsp2: M404V; nsp3: A256V","spike_mutations":"K187T"}}},{"name":"CH.1.1.21","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.08511000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":56.25},"frameShifts":{"value":"ORF7a:59-122"},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.frameShifts":{"value":"ORF7a:59-122"},"qc.frameShifts.totalFrameShifts":{"value":1},"immune_escape":{"value":"0.9441222497200389"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.21"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C17118T","A17940T","A23003T","T27565-","A27748-"],"ORF7a":["C58-"],"S":["N481Y"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: C58-; S: N481Y; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"N481Y"}}}]},{"name":"NODE_0000768","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{"nuc":["T22325C"],"S":["S255P"]},"labels":{"aa":"S: S255P","spike_mutations":"S255P"}},"children":[{"name":"CH.1.1.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.674296855926514}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000769","node_attrs":{"div":101,"Nextclade_pango":{"value":"GQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C4900A","G18025T","A21979G","T23018C","C24358T"],"S":["S486P"],"nsp13":["V597L"],"nsp3":["H727Q"]},"labels":{"aa":"S: S486P; nsp13: V597L; nsp3: H727Q","spike_mutations":"S486P"}},"children":[{"name":"GQ.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"GQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9334899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"GQ.1.1","node_attrs":{"div":107,"Nextclade_pango":{"value":"GQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9334899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.3.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T6634C","T10029C","C14183T","G22200A","C27532A","C28831A"],"ORF7a":["H47N"],"S":["G213E"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp12":["T248I"],"nsp4":["I492T"]},"labels":{"aa":"ORF7a: H47N; S: G213E; nsp1: G82-, H83-, V84-, M85V; nsp12: T248I; nsp4: I492T","spike_mutations":"G213E"}}}]}]},{"name":"NODE_0000770","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.513967990875244}},"branch_attrs":{"mutations":{"nuc":["T27576C"]}},"children":[{"name":"CH.1.1.10","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.10"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.265082836151123}},"branch_attrs":{"mutations":{"nuc":["G1589A","C9430T"],"nsp2":["G262S"]},"labels":{"aa":"nsp2: G262S"}}},{"name":"CH.1.1.15","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.15"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C9940T","A22108C"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}},{"name":"CH.1.1.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8057048320770264}},"branch_attrs":{"mutations":{"nuc":["C44T","A5802G","G7145A","C24210T"],"S":["T883I"],"nsp3":["Y1028C","G1476S"]},"labels":{"aa":"S: T883I; nsp3: Y1028C, G1476S","spike_mutations":"T883I"}}},{"name":"CH.1.1.24","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.24"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.005046367645264}},"branch_attrs":{"mutations":{"nuc":["T931C","T6676C"]}}},{"name":"CH.1.1.26","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.26"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1T","T2A","T3A","C29296T","T29793C"]}}},{"name":"CH.1.1.25","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.25"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["C1254T","C12854T"],"nsp2":["S150L"],"nsp9":["P57S"]},"labels":{"aa":"nsp2: S150L; nsp9: P57S"}}},{"name":"CH.1.1.29","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.29"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1376T","G23401T"],"S":["Q613H"],"nsp2":["P191S"]},"labels":{"aa":"S: Q613H; nsp2: P191S","spike_mutations":"Q613H"}}},{"name":"CH.1.1.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.68892765045166}},"branch_attrs":{"mutations":{"nuc":["A23604G","T23773C"],"S":["H681R"]},"labels":{"aa":"S: H681R","spike_mutations":"H681R"}}}]},{"name":"NODE_0000771","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{"nuc":["C1545T","A19886G","A22115G","T24991A"],"S":["N185D"],"nsp15":["K89R"],"nsp2":["A247V"]},"labels":{"aa":"S: N185D; nsp15: K89R; nsp2: A247V","spike_mutations":"N185D"}},"children":[{"name":"CH.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.010194778442383}},"branch_attrs":{"mutations":{}}},{"name":"DV.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"DV.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C44T","A23702G"],"S":["I714V"]},"labels":{"aa":"S: I714V","spike_mutations":"I714V"}}},{"name":"internal_ddb1","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.626544237136841}},"branch_attrs":{"mutations":{"nuc":["T4402A","C25721T"],"ORF3a":["A110V"]},"labels":{"aa":"ORF3a: A110V"}},"children":[{"name":"DV.2","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23267G"],"S":["I569V"]},"labels":{"aa":"S: I569V","spike_mutations":"I569V"}}},{"name":"DV.5","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C335T","G23401T"],"S":["Q613H"],"nsp1":["R24C"]},"labels":{"aa":"S: Q613H; nsp1: R24C","spike_mutations":"Q613H"}}},{"name":"DV.8","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8299T","C19602T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}},{"name":"internal_e719","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"DV.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"DV.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.046439170837402}},"branch_attrs":{"mutations":{"nuc":["G23401T","C29067T"],"N":["T265I"],"S":["Q613H"]},"labels":{"aa":"N: T265I; S: Q613H","spike_mutations":"Q613H"}}}]},{"name":"internal_fbb9","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G1394A","T13560C"],"nsp2":["E197K"]},"labels":{"aa":"nsp2: E197K"}},"children":[{"name":"DV.3","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{}}},{"name":"DV.3.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G15982A"],"nsp12":["V848I"]},"labels":{"aa":"nsp12: V848I"}}}]},{"name":"internal_56d62e69","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{"nuc":["T15591C"]}},"children":[{"name":"DV.6","node_attrs":{"div":102,"Nextclade_pango":{"value":"DV.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.8363285064697266}},"branch_attrs":{"mutations":{}}},{"name":"internal_656b8ca4","node_attrs":{"div":103,"Nextclade_pango":{"value":"DV.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.933734893798828}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"DV.6.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":73},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.187768459320068}},"branch_attrs":{"mutations":{"nuc":["C12073T"]}}},{"name":"DV.6.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"DV.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.6.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C6628T","C18032T"],"nsp13":["T599I"]},"labels":{"aa":"nsp13: T599I"}}}]}]},{"name":"internal_662f88a7","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C10908T","C24134A","T25959C"],"S":["L858I"],"nsp5":["A285V"]},"labels":{"aa":"S: L858I; nsp5: A285V","spike_mutations":"L858I"}},"children":[{"name":"DV.7","node_attrs":{"div":104,"Nextclade_pango":{"value":"DV.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"internal_19c380a1","node_attrs":{"div":108,"Nextclade_pango":{"value":"DV.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2227T","T4036A","C15026T","G25606A"],"ORF3a":["A72T"],"nsp12":["A529V"]},"labels":{"aa":"ORF3a: A72T; nsp12: A529V"}},"children":[{"name":"DV.7.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"DV.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C703T"]}}},{"name":"NODE_0000779","node_attrs":{"div":110,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.456613540649414}},"branch_attrs":{"mutations":{"nuc":["G22927T","T22928C"],"S":["L455F","F456L"]},"labels":{"aa":"S: L455F, F456L","spike_mutations":"L455F, F456L"}},"children":[{"name":"DV.7.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C25959T"]}}},{"name":"DV.7.1.8","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A8010G","C12119T","C24444T"],"S":["T961M"],"nsp3":["D1764G"],"nsp8":["P10S"]},"labels":{"aa":"S: T961M; nsp3: D1764G; nsp8: P10S","spike_mutations":"T961M"}}},{"name":"NODE_0000780","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27382T"],"ORF6":["L61F"]},"labels":{"aa":"ORF6: L61F"}},"children":[{"name":"DV.7.1.6","node_attrs":{"div":116,"Nextclade_pango":{"value":"DV.7.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G21724A","C22109A","T28007C","G28922T","G29830A"],"N":["A217S"],"S":["Q183K"]},"labels":{"aa":"N: A217S; S: Q183K","spike_mutations":"Q183K"}}},{"name":"DV.7.1.7","node_attrs":{"div":117,"Nextclade_pango":{"value":"DV.7.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.7"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C2262A","C3587T","T5122C","G21830A","C29095T"],"S":["V90I"],"nsp2":["T486N"],"nsp3":["H290Y"]},"labels":{"aa":"S: V90I; nsp2: T486N; nsp3: H290Y","spike_mutations":"V90I"}}}]},{"name":"internal_38689e19","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["C12750T","A24373G","A29558G"],"ORF10":["M1V"],"nsp9":["A22V"]},"labels":{"aa":"ORF10: M1V; nsp9: A22V"}},"children":[{"name":"DV.7.1.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{}}},{"name":"internal_47b5e065","node_attrs":{"div":114,"Nextclade_pango":{"value":"DV.7.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C7002T"],"nsp3":["S1428L"]},"labels":{"aa":"nsp3: S1428L"}},"children":[{"name":"JV.2","node_attrs":{"div":118,"Nextclade_pango":{"value":"JV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1063T","C2334T","G23876A","G29032A"],"S":["V772I"],"nsp2":["A510V"]},"labels":{"aa":"S: V772I; nsp2: A510V","spike_mutations":"V772I"}}},{"name":"JV.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"JV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.9432199999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":81},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G23015C"],"S":["G485R"]},"labels":{"aa":"S: G485R","spike_mutations":"G485R"}}}]}]},{"name":"NODE_0000783","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{"nuc":["A28676G"],"N":["T135A"]},"labels":{"aa":"N: T135A"}},"children":[{"name":"DV.7.1.5","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.464965343475342}},"branch_attrs":{"mutations":{}}},{"name":"KG.1","node_attrs":{"div":113,"Nextclade_pango":{"value":"KG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.331675052642822}},"branch_attrs":{"mutations":{"nuc":["C15240T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"KG.2","node_attrs":{"div":119,"Nextclade_pango":{"value":"KG.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.9432199999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.236487472982447"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.5.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","G564A","T5356A","C10336T","C21707T","C22353A","G23015C","C26907T"],"S":["H49Y","A264D","G485R"],"nsp1":["S100N"],"nsp3":["D879E"]},"labels":{"aa":"S: H49Y, A264D, G485R; nsp1: S100N; nsp3: D879E","spike_mutations":"H49Y, A264D, G485R"}}}]},{"name":"NODE_0000784","node_attrs":{"div":111,"Nextclade_pango":{"value":"DV.7.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}},"children":[{"name":"DV.7.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"DV.7.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}},{"name":"DV.7.1.3","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.6204705238342285}},"branch_attrs":{"mutations":{"nuc":["C9967T","G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}},{"name":"DV.7.1.4","node_attrs":{"div":112,"Nextclade_pango":{"value":"DV.7.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.103054523468018}},"branch_attrs":{"mutations":{"nuc":["G28001T"]}}},{"name":"DV.7.1.9","node_attrs":{"div":113,"Nextclade_pango":{"value":"DV.7.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.05117"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":80},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.1630613054040446"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.1.7.1.9"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","G25116A"],"S":["R1185H"]},"labels":{"aa":"S: R1185H","spike_mutations":"R1185H"}}}]}]}]}]}]}]},{"name":"NODE_0000785","node_attrs":{"div":96,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.0461344718933105}},"branch_attrs":{"mutations":{"nuc":["C21811T"]}},"children":[{"name":"CH.1.1.28","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.28"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C5812T","G16741T","T27832G"],"ORF7b":["I26S"],"nsp13":["V169F"]},"labels":{"aa":"ORF7b: I26S; nsp13: V169F"}}},{"name":"CH.1.1.32","node_attrs":{"div":101,"Nextclade_pango":{"value":"CH.1.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.32"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C2455T","A3186C","C14491T","C24134A","C28512A"],"N":["P80Q"],"ORF9b":["Q77K"],"S":["L858I"],"nsp3":["E156A"]},"labels":{"aa":"N: P80Q; ORF9b: Q77K; S: L858I; nsp3: E156A","spike_mutations":"L858I"}}},{"name":"NODE_0000786","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["G13441A","C28093T"],"ORF8":["S67F"]},"labels":{"aa":"ORF8: S67F"}},"children":[{"name":"CH.1.1.13","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.13"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C2485T","C25904T"],"ORF3a":["S171L"]},"labels":{"aa":"ORF3a: S171L"}}},{"name":"CH.1.1.14","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.14"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"CH.1.1.9","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.9"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A25256G","T28861C"],"S":["I1232V"]},"labels":{"aa":"S: I1232V","spike_mutations":"I1232V"}}}]},{"name":"NODE_0000787","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{"nuc":["G3791A"],"nsp3":["A358T"]},"labels":{"aa":"nsp3: A358T"}},"children":[{"name":"CH.1.1.11","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.256062984466553}},"branch_attrs":{"mutations":{}}},{"name":"GP.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"GP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["G21718T","C27476T"],"ORF7a":["T28I"],"S":["Q52H"]},"labels":{"aa":"ORF7a: T28I; S: Q52H","spike_mutations":"Q52H"}}},{"name":"GP.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"GP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["T13450C","C27323T"],"ORF6":["S41F"]},"labels":{"aa":"ORF6: S41F"}}},{"name":"GP.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"GP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.11.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T5218C","A16878G","A26519G","C29236T"]}}}]},{"name":"NODE_0000788","node_attrs":{"div":97,"Nextclade_pango":{"value":"CH.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-3.320462703704834}},"branch_attrs":{"mutations":{"nuc":["C193T"]}},"children":[{"name":"CH.1.1.16","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.16"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C11620T","G23401T","C25469T"],"ORF3a":["S26L"],"S":["Q613H"]},"labels":{"aa":"ORF3a: S26L; S: Q613H","spike_mutations":"Q613H"}}},{"name":"CH.1.1.20","node_attrs":{"div":104,"Nextclade_pango":{"value":"CH.1.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.20"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21T","G2357A","C22458T","G22770A","A25056G","C27389T","A29567G"],"ORF10":["I4V"],"S":["T299I","R403K","D1165G"],"nsp2":["A518T"]},"labels":{"aa":"ORF10: I4V; S: T299I, R403K, D1165G; nsp2: A518T","spike_mutations":"T299I, R403K, D1165G"}}},{"name":"CH.1.1.23","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.23"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.915510177612305}},"branch_attrs":{"mutations":{"nuc":["C22530A","A24772G"],"S":["T323K"]},"labels":{"aa":"S: T323K","spike_mutations":"T323K"}}},{"name":"CH.1.1.22","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.22"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8814T","T17349C","A23598G","C24466T","C26885T","A27269T"],"ORF6":["K23I"],"S":["K679R"],"nsp4":["A87V"]},"labels":{"aa":"ORF6: K23I; S: K679R; nsp4: A87V","spike_mutations":"K679R"}}},{"name":"CH.1.1.30","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.30"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T9167C","C24337T"],"nsp4":["Y205H"]},"labels":{"aa":"nsp4: Y205H"}}},{"name":"CH.1.1.6","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.6"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.377432346343994}},"branch_attrs":{"mutations":{"nuc":["A1278G","C5622T","C23757T"],"S":["T732I"],"nsp2":["K158R"],"nsp3":["P968L"]},"labels":{"aa":"S: T732I; nsp2: K158R; nsp3: P968L","spike_mutations":"T732I"}}},{"name":"CH.1.1.5","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["C12781T","T17112C","C25702T"],"ORF3a":["P104S"]},"labels":{"aa":"ORF3a: P104S"}}},{"name":"CH.1.1.8","node_attrs":{"div":99,"Nextclade_pango":{"value":"CH.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.8"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.40684175491333}},"branch_attrs":{"mutations":{"nuc":["C12412T","C24099T"],"S":["A846V"]},"labels":{"aa":"S: A846V","spike_mutations":"A846V"}}},{"name":"NODE_0000789","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.12"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1722T","C6016T","C24134A"],"S":["L858I"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp2":["A306V"]},"labels":{"aa":"S: L858I; nsp1: G82-, H83-, V84-, M85V; nsp2: A306V","spike_mutations":"L858I"}},"children":[{"name":"CH.1.1.12","node_attrs":{"div":100,"Nextclade_pango":{"value":"CH.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":71},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.729614734649658}},"branch_attrs":{"mutations":{}}},{"name":"FS.1","node_attrs":{"div":101,"Nextclade_pango":{"value":"FS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.12.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["A12162G"],"nsp8":["Q24R"]},"labels":{"aa":"nsp8: Q24R"}}}]},{"name":"NODE_0000790","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.19"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{"nuc":["C2773T"]}},"children":[{"name":"CH.1.1.19","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":68},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.5471086502075195}},"branch_attrs":{"mutations":{}}},{"name":"FJ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"FJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":70},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.19.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C3876T","A27277G"],"ORF6":["I26V"],"nsp3":["A386V"]},"labels":{"aa":"ORF6: I26V; nsp3: A386V"}}}]},{"name":"NODE_0000791","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A2043G","C4754T","C8637T","G16537A","T16599C","A24727G"],"nsp13":["D101N"],"nsp2":["N413S"],"nsp3":["P679S"],"nsp4":["T28I"]},"labels":{"aa":"nsp13: D101N; nsp2: N413S; nsp3: P679S; nsp4: T28I"}},"children":[{"name":"CH.1.1.31","node_attrs":{"div":103,"Nextclade_pango":{"value":"CH.1.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000792","node_attrs":{"div":108,"Nextclade_pango":{"value":"JP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G7059A","G21668A","G22104A","G22770A","C25587A","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-"],"ORF7a":["P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-"],"S":["V36I","G181E","R403K"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp3":["G1447D"]},"labels":{"aa":"ORF7a: P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-; S: V36I, G181E, R403K; nsp1: G82-, H83-, V84-, M85-, V86-; nsp3: G1447D","spike_mutations":"V36I, G181E, R403K"}},"children":[{"name":"JP.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"JP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:62-122"},"designation_date":{"value":"2023-09-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JP.1.1","node_attrs":{"div":115,"Nextclade_pango":{"value":"JP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.05667"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":79},"totalAminoacidDeletions":{"value":34},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:62-122"},"designation_date":{"value":"2023-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0267165804076408"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.31.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4890T","C14340T","G15780A","C19983T","G25218T","C26212T","T27383A"],"ORF3a":["P274S"],"ORF6":["L61H"],"S":["G1219V"],"nsp3":["T724I"]},"labels":{"aa":"ORF3a: P274S; ORF6: L61H; S: G1219V; nsp3: T724I","spike_mutations":"G1219V"}}}]}]}]},{"name":"internal_6111d1af","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.17"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{"nuc":["A27156G","C29555T"],"M":["S212G"]},"labels":{"aa":"M: S212G"}},"children":[{"name":"CH.1.1.17","node_attrs":{"div":98,"Nextclade_pango":{"value":"CH.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":69},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.918494701385498}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000794","node_attrs":{"div":102,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C11750T","C18657T","A22206G","G23401T"],"S":["D215G","Q613H"],"nsp6":["L260F"]},"labels":{"aa":"S: D215G, Q613H; nsp6: L260F","spike_mutations":"D215G, Q613H"}},"children":[{"name":"FK.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":72},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{}}},{"name":"internal_6bb31b02","node_attrs":{"div":105,"Nextclade_pango":{"value":"FK.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1415T","G1914A","C27389T"],"nsp2":["L204F","R370H"]},"labels":{"aa":"nsp2: L204F, R370H"}},"children":[{"name":"FK.1.2","node_attrs":{"div":105,"Nextclade_pango":{"value":"FK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.2.1","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C2937T"],"nsp3":["T73I"]},"labels":{"aa":"nsp3: T73I"}}},{"name":"FK.1.2.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":78},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.2.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G680A","G942A","C1931A","T11737C","C25583A"],"ORF3a":["T64N"],"nsp1":["D139N"],"nsp2":["R46K","Q376K"]},"labels":{"aa":"ORF3a: T64N; nsp1: D139N; nsp2: R46K, Q376K"}}}]},{"name":"NODE_0000796","node_attrs":{"div":103,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C27804T"]}},"children":[{"name":"internal_637a2219","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21T","C23673T","T27511C"],"ORF7a":["Y40H"],"S":["S704L"]},"labels":{"aa":"ORF7a: Y40H; S: S704L","spike_mutations":"S704L"}},"children":[{"name":"FK.1.4","node_attrs":{"div":106,"Nextclade_pango":{"value":"FK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.4.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.4.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G11521A","G22104C"],"S":["G181A"],"nsp6":["M183I"]},"labels":{"aa":"S: G181A; nsp6: M183I","spike_mutations":"G181A"}}}]},{"name":"NODE_0000798","node_attrs":{"div":107,"Nextclade_pango":{"value":"FK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.93373441696167}},"branch_attrs":{"mutations":{"nuc":["T1465C","C21205A","A23416T","G28374A"],"N":["-31E","G34-"],"ORF9b":["G31R"],"nsp16":["L183I"]},"labels":{"aa":"N: -31E, G34-; ORF9b: G31R; nsp16: L183I"}},"children":[{"name":"FK.1.5","node_attrs":{"div":109,"Nextclade_pango":{"value":"FK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":74},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.5"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["G5155A","C12439T"]}}},{"name":"NODE_0000799","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{"nuc":["G3443A"],"nsp3":["A242T"]},"labels":{"aa":"nsp3: A242T"}},"children":[{"name":"FK.1.1.1","node_attrs":{"div":112,"Nextclade_pango":{"value":"FK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.16085999999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":77},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9815994835819151"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","C4320T","C7765T","T22896C"],"S":["V445A"],"nsp3":["A534V"]},"labels":{"aa":"S: V445A; nsp3: A534V","spike_mutations":"V445A"}}},{"name":"FK.1.1","node_attrs":{"div":108,"Nextclade_pango":{"value":"FK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.322466850280762}},"branch_attrs":{"mutations":{}}},{"name":"FK.1.1.2","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.1.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.168172836303711}},"branch_attrs":{"mutations":{"nuc":["C9223T","T23071G"]}}}]},{"name":"internal_5be7761b","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["T241-","C3874T","G18984A","G26888A"],"nsp14":["M315I"]},"labels":{"aa":"nsp14: M315I"}},"children":[{"name":"FK.1.3","node_attrs":{"div":110,"Nextclade_pango":{"value":"FK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.260319232940674}},"branch_attrs":{"mutations":{"nuc":["-241C"]}}},{"name":"FK.1.3.1","node_attrs":{"div":111,"Nextclade_pango":{"value":"FK.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G23311C"],"S":["E583D"]},"labels":{"aa":"S: E583D","spike_mutations":"E583D"}}},{"name":"NODE_0000801","node_attrs":{"div":113,"Nextclade_pango":{"value":"FK.1.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C44T","C9391T","T13596C"]}},"children":[{"name":"FK.1.3.2","node_attrs":{"div":113,"Nextclade_pango":{"value":"FK.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":75},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"JL.1","node_attrs":{"div":116,"Nextclade_pango":{"value":"JL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32796"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":76},"totalAminoacidDeletions":{"value":12},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9092912257894785"},"clade_display":{"value":"23C (CH.1.1)"},"partiallyAliased":{"value":"BA.2.75.3.4.1.1.1.1.17.1.3.2.1"},"clade_nextstrain":{"value":"23C"},"clade_membership":{"value":"23C"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C17352T","G24893C","T25812C"],"S":["E1111Q"]},"labels":{"aa":"S: E1111Q","spike_mutations":"E1111Q"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"NODE_0000802","node_attrs":{"div":120,"Nextclade_pango":{"value":"BA.2.86"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.651820659637451}},"branch_attrs":{"mutations":{"nuc":["C21T","C897A","G3431T","A7842G","C8293T","G8393A","G11042T","C12789T","T13339C","T15756A","A18492G","C21622T","G21624C","C21711T","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","G21941T","T21992-","A21993-","T21994-","T22032C","C22033A","A22034G","A22194-","T22195-","T22196-","C22208T","C22295A","C22353A","A22556G","G22577C","A22629C","G22770A","G22895C","T22896A","G22898A","A22910G","C22916T","T22917G","T22942A","T23005A","G23009-","T23010-","T23011-","G23012A","C23013A","T23018C","T23019C","G23040A","G23222A","C23271T","C23423T","A23604G","C24378T","C24990T","C25207T","G26529C","A26610G","C26681T","C26833T","C28958A"],"M":["D3H","T30A","A104V"],"N":["Q229K"],"S":["R21T","S50L","H69-","V70-","V127F","Y144-","F157S","R158G","N211-","L212I","L216F","H245N","A264D","I332V","D339H","K356T","R403K","V445H","G446S","N450D","L452W","N460K","N481K","V483-","A484K","F486P","R493Q","E554K","A570V","P621S","H681R","S939F","P1143L"],"nsp2":["A31D"],"nsp3":["V238L","N1708S","A1892T"],"nsp6":["V24F"],"nsp9":["T35I"]},"labels":{"aa":"M: D3H, T30A, A104V; N: Q229K; S: R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L; nsp2: A31D; nsp3: V238L, N1708S, A1892T; nsp6: V24F; nsp9: T35I","clade":"23I","spike_mutations":"R21T, S50L, H69-, V70-, V127F, Y144-, F157S, R158G, N211-, L212I, L216F, H245N, A264D, I332V, D339H, K356T, R403K, V445H, G446S, N450D, L452W, N460K, N481K, V483-, A484K, F486P, R493Q, E554K, A570V, P621S, H681R, S939F, P1143L"}},"children":[{"name":"BA.2.86","node_attrs":{"div":120,"Nextclade_pango":{"value":"BA.2.86"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.651820659637451}},"branch_attrs":{"mutations":{}}},{"name":"BA.2.86.2","node_attrs":{"div":121,"Nextclade_pango":{"value":"BA.2.86.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["G27459T"],"ORF7a":["E22D"]},"labels":{"aa":"ORF7a: E22D"}}},{"name":"BA.2.86.6","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T"]}}},{"name":"BA.2.86.5","node_attrs":{"div":125,"Nextclade_pango":{"value":"BA.2.86.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C44T","C5575T","T6085C","A22151G","T23278C"],"S":["I197V"]},"labels":{"aa":"S: I197V","spike_mutations":"I197V"}}},{"name":"BA.2.86.4","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T11940C","C22227T"],"S":["A222V"],"nsp7":["V33A"]},"labels":{"aa":"S: A222V; nsp7: V33A","spike_mutations":"A222V"}}},{"name":"LV.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"LV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21C","C9226T","G14347A"],"nsp12":["D303N"]},"labels":{"aa":"nsp12: D303N"}}},{"name":"LV.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.6.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T21C","C44T","A708G","G1738T","G2155T","G3470A","C9226T","G10902A","C13339T","C15026T","C16887T","G22599C","T22926C","T22928C","C24034T","C27059T"],"S":["R346T","L455S","F456L"],"nsp1":["E148G"],"nsp12":["A529V"],"nsp2":["W450C"],"nsp3":["G251R"],"nsp5":["G283D"]},"labels":{"aa":"S: R346T, L455S, F456L; nsp1: E148G; nsp12: A529V; nsp2: W450C; nsp3: G251R; nsp5: G283D","spike_mutations":"R346T, L455S, F456L"}}},{"name":"NODE_0000803","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T10819C","T17497C","C28720T"],"nsp13":["Y421H"]},"labels":{"aa":"nsp13: Y421H"}},"children":[{"name":"BA.2.86.7","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000804","node_attrs":{"div":128,"Nextclade_pango":{"value":"MP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21646T","A23021G","A23089G","C28115T"],"S":["N487D"]},"labels":{"aa":"S: N487D","spike_mutations":"N487D"}},"children":[{"name":"MP.1","node_attrs":{"div":128,"Nextclade_pango":{"value":"MP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"MP.1.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"MP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.12555999999999995"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.6738025507980547"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.7.1.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G22599C","G22604C"],"S":["R346T","A348P"]},"labels":{"aa":"S: R346T, A348P","spike_mutations":"R346T, A348P"}}}]}]},{"name":"NODE_0000805","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C44T","C222T","C1960T","T12775C"]}},"children":[{"name":"BA.2.86.3","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":82},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{}}},{"name":"JQ.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.7617998123168945}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"NODE_0000806","node_attrs":{"div":126,"Nextclade_pango":{"value":"JQ.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2944A","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JQ.2","node_attrs":{"div":126,"Nextclade_pango":{"value":"JQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.15919"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.450453001635465"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000807","node_attrs":{"div":130,"Nextclade_pango":{"value":"JQ.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C11396T","T22926C"],"S":["L455S"],"nsp6":["L142F"]},"labels":{"aa":"S: L455S; nsp6: L142F","spike_mutations":"L455S"}},"children":[{"name":"JQ.2.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JQ.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JQ.2.1.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"JQ.2.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C44T","T1270C","A12064G","G15906T","C17977T","A20334G","C23277T"],"S":["T572I"],"nsp12":["Q822H"],"nsp13":["L581F"]},"labels":{"aa":"S: T572I; nsp12: Q822H; nsp13: L581F","spike_mutations":"T572I"}}},{"name":"JQ.2.1.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JQ.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.3.2.1.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C1059T","C7639T","T22928C","T25760C"],"ORF3a":["I123T"],"S":["F456L"],"nsp2":["T85I"]},"labels":{"aa":"ORF3a: I123T; S: F456L; nsp2: T85I","spike_mutations":"F456L"}}}]}]}]},{"name":"NODE_0000808","node_attrs":{"div":122,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.782770156860352}},"branch_attrs":{"mutations":{"nuc":["C44T","A6183G"],"nsp3":["K1155R"]},"labels":{"aa":"nsp3: K1155R"}},"children":[{"name":"JN.4","node_attrs":{"div":123,"Nextclade_pango":{"value":"JN.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.51897668838501}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000809","node_attrs":{"div":123,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.825653314590454}},"branch_attrs":{"mutations":{"nuc":["C12815T"]}},"children":[{"name":"BA.2.86.1","node_attrs":{"div":123,"Nextclade_pango":{"value":"BA.2.86.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.825653314590454}},"branch_attrs":{"mutations":{}}},{"name":"JN.12","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.12"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1758G","T22928G"],"S":["F456V"],"nsp2":["A318G"]},"labels":{"aa":"S: F456V; nsp2: A318G","spike_mutations":"F456V"}}},{"name":"JN.14","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.14"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6750288009643555}},"branch_attrs":{"mutations":{"nuc":["A1T","C23601T","C29614T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.16","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.16"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6085710525512695}},"branch_attrs":{"mutations":{"nuc":["C26078T"],"ORF3a":["T229I"]},"labels":{"aa":"ORF3a: T229I"}}},{"name":"JN.18","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.18"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.011676788330078}},"branch_attrs":{"mutations":{"nuc":["T11614C"]}}},{"name":"JN.15","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.15"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.6716227531433105}},"branch_attrs":{"mutations":{"nuc":["C24319T","G29781T"]}}},{"name":"JN.19","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.19"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.808485984802246}},"branch_attrs":{"mutations":{"nuc":["A14601G"]}}},{"name":"JN.17","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.17"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.986441135406494}},"branch_attrs":{"mutations":{"nuc":["T2A","C12781T"]}}},{"name":"JN.6","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.6"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.403351783752441}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.7","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.7"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","G23342A"],"S":["G594S"]},"labels":{"aa":"S: G594S","spike_mutations":"G594S"}}},{"name":"JN.9","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.9"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.700376033782959}},"branch_attrs":{"mutations":{"nuc":["G25249A"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}}},{"name":"JN.8","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.8"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22458T","G28904T"],"N":["A211S"],"S":["T299I"]},"labels":{"aa":"N: A211S; S: T299I","spike_mutations":"T299I"}}},{"name":"NODE_0000810","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{"nuc":["G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.11.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A12889G","T22926C","C29762T"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.11","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.11"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.075150489807129}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0000811","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A14397G"]}},"children":[{"name":"JN.13","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":83},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"JN.13.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.13.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-6.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}}]},{"name":"NODE_0000812","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{"nuc":["C28677T"],"N":["T135I"]},"labels":{"aa":"N: T135I"}},"children":[{"name":"JN.5","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.247353553771973}},"branch_attrs":{"mutations":{}}},{"name":"JN.5.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6465599999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.5.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2950A","G4720A","C5806T","G16416T","G22985T","C26058T","A28052G","C29541T"],"S":["A475S"]},"labels":{"aa":"S: A475S","spike_mutations":"A475S"}}}]},{"name":"NODE_0000813","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{"nuc":["T44C","C6525T"],"nsp3":["T1269I"]},"labels":{"aa":"nsp3: T1269I"}},"children":[{"name":"JN.3.1","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["G24328C","C27476T"],"ORF7a":["T28I"],"S":["L922F"]},"labels":{"aa":"ORF7a: T28I; S: L922F","spike_mutations":"L922F"}}},{"name":"JN.3","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.346826076507568}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.3","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A5641G","C14478T","C21676T"]}}},{"name":"NODE_0000814","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C2939T","C29171T"],"N":["H300Y"],"nsp3":["P74S"]},"labels":{"aa":"N: H300Y; nsp3: P74S"}},"children":[{"name":"JN.3.2","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"JN.3.2.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2850199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.4889947175626428"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.3.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A17637G","T22928G","C29095T","C29253T"],"N":["S327L"],"S":["F456V"]},"labels":{"aa":"N: S327L; S: F456V","spike_mutations":"F456V"}}}]}]},{"name":"internal_59b29264","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{"nuc":["A2127G"],"nsp2":["Y441C"]},"labels":{"aa":"nsp2: Y441C"}},"children":[{"name":"JN.2","node_attrs":{"div":124,"Nextclade_pango":{"value":"JN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-3.9368481636047363}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.1","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.2.3","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.3"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["G22139T"],"S":["V193L"]},"labels":{"aa":"S: V193L","spike_mutations":"V193L"}}},{"name":"JN.2.5","node_attrs":{"div":126,"Nextclade_pango":{"value":"JN.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.5"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["T44C","T22926C"],"S":["L455S"]},"labels":{"aa":"S: L455S","spike_mutations":"L455S"}}},{"name":"JN.2.4","node_attrs":{"div":127,"Nextclade_pango":{"value":"JN.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":85},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.4"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.234764575958252}},"branch_attrs":{"mutations":{"nuc":["T44C","G12310A","C22286T"],"S":["L242F"]},"labels":{"aa":"S: L242F","spike_mutations":"L242F"}}},{"name":"NODE_0000816","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T1030C","C11195T","C23277T","G28346T"],"N":["G25C"],"S":["T572I"],"nsp6":["L75F"]},"labels":{"aa":"N: G25C; S: T572I; nsp6: L75F","spike_mutations":"T572I"}},"children":[{"name":"JN.2.2","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04777"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.282711495408898"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"JN.2.2.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.2.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.3844699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3875211680198292"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.2.2.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T17358C","A23021G"],"S":["N487D"],"nsp1":["G82-","H83-","V84-","M85V"]},"labels":{"aa":"S: N487D; nsp1: G82-, H83-, V84-, M85V","spike_mutations":"N487D"}}}]}]},{"name":"NODE_0000817","node_attrs":{"div":124,"Nextclade_pango":{"value":"BA.2.86.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.369624137878418}},"branch_attrs":{"mutations":{"nuc":["T3565C"]}},"children":[{"name":"JN.10","node_attrs":{"div":125,"Nextclade_pango":{"value":"JN.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.32843999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":84},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.45439241518997"},"clade_display":{"value":"23I (BA.2.86)"},"partiallyAliased":{"value":"BA.2.86.1.10"},"clade_nextstrain":{"value":"23I"},"clade_membership":{"value":"23I"},"placement_prior":{"value":-4.502436637878418}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"NODE_0000818","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.787649631500244}},"branch_attrs":{"mutations":{"nuc":["G11727A","C18894T","T22926C","T27810C"],"ORF7b":["F19L"],"S":["L455S"],"nsp6":["R252K"]},"labels":{"aa":"ORF7b: F19L; S: L455S; nsp6: R252K","clade":"24A","spike_mutations":"L455S"}},"children":[{"name":"JN.1","node_attrs":{"div":128,"Nextclade_pango":{"value":"JN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.787649631500244}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.10","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.10"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.408924102783203}},"branch_attrs":{"mutations":{"nuc":["C21846T"],"S":["T95I"]},"labels":{"aa":"S: T95I","spike_mutations":"T95I"}}},{"name":"JN.1.12","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.26806999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.12"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.2179484367370605}},"branch_attrs":{"mutations":{"nuc":["C106T","T22928G","G27415A"],"ORF7a":["A8T"],"S":["F456V"]},"labels":{"aa":"ORF7a: A8T; S: F456V","spike_mutations":"F456V"}}},{"name":"JN.1.17","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.17"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.394025802612305}},"branch_attrs":{"mutations":{"nuc":["C19593T","C22227T","T22669C"],"S":["A222V"]},"labels":{"aa":"S: A222V","spike_mutations":"A222V"}}},{"name":"JN.1.19","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.19"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9045872688293457}},"branch_attrs":{"mutations":{"nuc":["C1060T","A28104G"],"ORF8":["I71V"]},"labels":{"aa":"ORF8: I71V"}}},{"name":"JN.1.21","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.21"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.875349044799805}},"branch_attrs":{"mutations":{"nuc":["C24734T"],"S":["H1058Y"]},"labels":{"aa":"S: H1058Y","spike_mutations":"H1058Y"}}},{"name":"JN.1.20","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.20"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062768936157227}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"JN.1.22","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.22"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.6741955280303955}},"branch_attrs":{"mutations":{"nuc":["C1779T","C13019T","C16887T"],"nsp2":["S325F"]},"labels":{"aa":"nsp2: S325F"}}},{"name":"JN.1.28","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.404186248779297}},"branch_attrs":{"mutations":{"nuc":["C24034T","A29700G"]}}},{"name":"JN.1.3","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.493562698364258}},"branch_attrs":{"mutations":{"nuc":["C27945T"],"ORF8":["Q18*"]},"labels":{"aa":"ORF8: Q18*"}}},{"name":"JN.1.31","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.31"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9726529121398926}},"branch_attrs":{"mutations":{"nuc":["C18687T","C19186T","G25429T"],"ORF3a":["V13L"]},"labels":{"aa":"ORF3a: V13L"}}},{"name":"JN.1.34","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.34"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.485931396484375}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"JN.1.37","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.37"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.403597354888916}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}},{"name":"JN.1.40","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.40"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.030079364776611}},"branch_attrs":{"mutations":{"nuc":["T21653C"],"S":["S31P"]},"labels":{"aa":"S: S31P","spike_mutations":"S31P"}}},{"name":"JN.1.46","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.46"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.232482433319092}},"branch_attrs":{"mutations":{"nuc":["T4885C","C9611T"],"nsp4":["L353F"]},"labels":{"aa":"nsp4: L353F"}}},{"name":"JN.1.45","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.45"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.296973705291748}},"branch_attrs":{"mutations":{"nuc":["G18756T"]}}},{"name":"JN.1.5","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.8042540550231934}},"branch_attrs":{"mutations":{"nuc":["C5986T","G17278A","T17279C"],"nsp13":["V348T"]},"labels":{"aa":"nsp13: V348T"}}},{"name":"JN.1.52","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.52"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.117435932159424}},"branch_attrs":{"mutations":{"nuc":["A10323G"],"nsp5":["K90R"]},"labels":{"aa":"nsp5: K90R"}}},{"name":"JN.1.61","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.93036"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.496607246855186"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.61"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.40602445602417}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"JN.1.62","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.62"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C2710A","C4586T","G21746T","T22928C","G23604A"],"S":["V62F","F456L","R681H"]},"labels":{"aa":"S: V62F, F456L, R681H","spike_mutations":"V62F, F456L, R681H"}}},{"name":"JN.1.60","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.60"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.340050220489502}},"branch_attrs":{"mutations":{"nuc":["C4543T"]}}},{"name":"JN.1.66","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.66"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6701T","C7113T","G22468A","A22896C","T22930A","C24912T","C25708T","T25899C","T27484C","T28618C"],"ORF3a":["L106F"],"S":["H445P","F456L","T1117I"],"nsp3":["L1328F","T1465I"]},"labels":{"aa":"ORF3a: L106F; S: H445P, F456L, T1117I; nsp3: L1328F, T1465I","spike_mutations":"H445P, F456L, T1117I"}}},{"name":"internal_67e01226","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.1086554527282715}},"branch_attrs":{"mutations":{"nuc":["C20930T","G25249T"],"S":["M1229I"],"nsp16":["T91M"]},"labels":{"aa":"S: M1229I; nsp16: T91M","spike_mutations":"M1229I"}},"children":[{"name":"JN.1.2.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.971951484680176}},"branch_attrs":{"mutations":{"nuc":["C24863T","A27540G"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"JN.1.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.1086554527282715}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d66d4adf","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.240773677825928}},"branch_attrs":{"mutations":{"nuc":["C1185T","C6696T","A22893G","A22920T","A24457G"],"S":["K444R","Y453F"],"nsp2":["A127V"],"nsp3":["P1326L"]},"labels":{"aa":"S: K444R, Y453F; nsp2: A127V; nsp3: P1326L","spike_mutations":"K444R, Y453F"}},"children":[{"name":"JN.1.23","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.21099"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.240773677825928}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.23.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.23.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.21099"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.535410297587269"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.23.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T44C","C3653T","C6896T","T21973G","G25352T"],"S":["N137K","V1264L"],"nsp3":["L312F"]},"labels":{"aa":"S: N137K, V1264L; nsp3: L312F","spike_mutations":"N137K, V1264L"}}}]},{"name":"internal_f571b810","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.24"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.012888431549072}},"branch_attrs":{"mutations":{"nuc":["G25290T"],"S":["C1243F"]},"labels":{"aa":"S: C1243F","spike_mutations":"C1243F"}},"children":[{"name":"JN.1.24","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.012888431549072}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.24.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.24.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.24.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3227362632751465}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_782b2c7a","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.32"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.161813735961914}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.32.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.32.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.261450290679932}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}}},{"name":"JN.1.32","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.32"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.161813735961914}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_613b5275","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.844100475311279}},"branch_attrs":{"mutations":{"nuc":["G18674A"],"nsp14":["R212K"]},"labels":{"aa":"nsp14: R212K"}},"children":[{"name":"JN.1.38.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C11572T","G21665A","G25690A"],"ORF3a":["G100S"],"S":["G35S"]},"labels":{"aa":"ORF3a: G100S; S: G35S","spike_mutations":"G35S"}}},{"name":"JN.1.38","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.38"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.844100475311279}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_01602336","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.43"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.39068078994751}},"branch_attrs":{"mutations":{"nuc":["A1T","A25327G"]}},"children":[{"name":"JN.1.43","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.39068078994751}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.43.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.43.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.43.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.052921295166016}},"branch_attrs":{"mutations":{"nuc":["C19488T","C29218T"]}}}]},{"name":"internal_09bf20a8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.44"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.741299152374268}},"branch_attrs":{"mutations":{"nuc":["C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"JN.1.44","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.741299152374268}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.44.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.44.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.44.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.847970962524414}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_b87d64b9","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.54"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.473522663116455}},"branch_attrs":{"mutations":{"nuc":["A1G","A9085G"]}},"children":[{"name":"JN.1.54.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"JN.1.54.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.05681999999999991"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.532734695870142"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G6443A","T6552C","C9886T","C12400T","T17556C","G22201A","G22781A","T22928C"],"S":["V407I","F456L"],"nsp3":["D1242N","M1278T"]},"labels":{"aa":"S: V407I, F456L; nsp3: D1242N, M1278T","spike_mutations":"V407I, F456L"}}},{"name":"JN.1.54","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.54"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.473522663116455}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_e23f2bfa","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.56"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.906276226043701}},"branch_attrs":{"mutations":{"nuc":["C26029A"],"ORF3a":["Q213K"]},"labels":{"aa":"ORF3a: Q213K"}},"children":[{"name":"JN.1.56.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.56.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7602899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5395016697354735"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2G","C5178T","T8278C","G22103A","G22599C","T22928G","A23012G"],"S":["G181R","R346T","F456V","K484E"],"nsp3":["T820I"]},"labels":{"aa":"S: G181R, R346T, F456V, K484E; nsp3: T820I","spike_mutations":"G181R, R346T, F456V, K484E"}}},{"name":"JN.1.56","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.56"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.906276226043701}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_c73d4b7b","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.59"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.803280353546143}},"branch_attrs":{"mutations":{"nuc":["G3875T"],"nsp3":["A386S"]},"labels":{"aa":"nsp3: A386S"}},"children":[{"name":"JN.1.59","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.803280353546143}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.59.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.59.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":8.507},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.59.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2786G","C5192T","A5455G","C7639T","C10834T","T21653-","C21654-","T21655-","G22132T","G22599C","T29512C"],"S":["S31-","R190S","R346T"],"nsp3":["I23V"]},"labels":{"aa":"S: S31-, R190S, R346T; nsp3: I23V","spike_mutations":"S31-, R190S, R346T"}}}]},{"name":"internal_be5f0a35","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.234124660491943}},"branch_attrs":{"mutations":{"nuc":["G22627A"]}},"children":[{"name":"JN.1.6","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.234124660491943}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.6.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.492287635803223}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0000830","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.63"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.16524600982666}},"branch_attrs":{"mutations":{"nuc":["A13712G"],"nsp12":["K91R"]},"labels":{"aa":"nsp12: K91R"}},"children":[{"name":"JN.1.63","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.16524600982666}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.63.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.63.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.63.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.744444847106934}},"branch_attrs":{"mutations":{"nuc":["T4804G","G7850T"],"nsp3":["D695E","A1711S"]},"labels":{"aa":"nsp3: D695E, A1711S"}}}]},{"name":"internal_4e516d94","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.0482683181762695}},"branch_attrs":{"mutations":{"nuc":["C706T","A7708T"]}},"children":[{"name":"JN.1.25","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.0482683181762695}},"branch_attrs":{"mutations":{}}},{"name":"internal_1dca60b9","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.25.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.25026273727417}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.25.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.25026273727417}},"branch_attrs":{"mutations":{}}},{"name":"LM.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.25.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7318T","C14183T","T22928C","G26648A","C28948T"],"S":["F456L"],"nsp12":["T248I"]},"labels":{"aa":"S: F456L; nsp12: T248I","spike_mutations":"F456L"}}}]}]},{"name":"internal_ddb62e17","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.29"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.394768238067627}},"branch_attrs":{"mutations":{"nuc":["C2644T","A9935G"],"nsp4":["T461A"]},"labels":{"aa":"nsp4: T461A"}},"children":[{"name":"JN.1.29","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.394768238067627}},"branch_attrs":{"mutations":{}}},{"name":"internal_dc48128a","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.29.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.341370582580566}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.29.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.29.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.341370582580566}},"branch_attrs":{"mutations":{"nuc":["T44C"]}}},{"name":"MJ.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.29.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G6473A","T17364C","T21653C","G22599C","A28254-"],"ORF8":["I121-"],"S":["S31P","R346T"],"nsp3":["E1252K"]},"labels":{"aa":"ORF8: I121-; S: S31P, R346T; nsp3: E1252K","spike_mutations":"S31P, R346T"}}}]}]},{"name":"internal_e4ec80d6","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4552714824676514}},"branch_attrs":{"mutations":{"nuc":["A29086T"]}},"children":[{"name":"JN.1.41","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.41"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C12616T","C15480T","C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"internal_9f737028","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.36"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.332234859466553}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}},"children":[{"name":"JN.1.36","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.332234859466553}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.36.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.36.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.36.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.063130855560303}},"branch_attrs":{"mutations":{"nuc":["C23601T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_5075b334","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.47"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005667686462402}},"branch_attrs":{"mutations":{"nuc":["C7594T","C8074T"]}},"children":[{"name":"JN.1.47","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005667686462402}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.47.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.47.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C1385T","C23277T","G23610A"],"S":["T572I","R683Q"],"nsp2":["H194Y"]},"labels":{"aa":"S: T572I, R683Q; nsp2: H194Y","spike_mutations":"T572I, R683Q"}}},{"name":"JN.1.47.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.47.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.47.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.993497371673584}},"branch_attrs":{"mutations":{"nuc":["C22224T"],"S":["S221L"]},"labels":{"aa":"S: S221L","spike_mutations":"S221L"}}}]},{"name":"internal_6ccabb36","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.51"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.403688907623291}},"branch_attrs":{"mutations":{"nuc":["C4795T"]}},"children":[{"name":"JN.1.51","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.403688907623291}},"branch_attrs":{"mutations":{}}},{"name":"internal_9162daad","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.51.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.081462383270264}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.51.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.51.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.081462383270264}},"branch_attrs":{"mutations":{}}},{"name":"LJ.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.51.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C20016T","C21627A","A24727T","T28251G","C28253T","A28254C"],"ORF8":["F120V","I121L"],"S":["T22N"]},"labels":{"aa":"ORF8: F120V, I121L; S: T22N","spike_mutations":"T22N"}}}]}]},{"name":"internal_fd42b206","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.513101100921631}},"branch_attrs":{"mutations":{"nuc":["A1461G"],"nsp2":["K219R"]},"labels":{"aa":"nsp2: K219R"}},"children":[{"name":"JN.1.55","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.513101100921631}},"branch_attrs":{"mutations":{}}},{"name":"internal_9c8a05f6","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.55"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.7709059715271}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.55.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.55.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.627852916717529}},"branch_attrs":{"mutations":{"nuc":["C20429A"],"nsp15":["P270H"]},"labels":{"aa":"nsp15: P270H"}}},{"name":"JN.1.55.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.55.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.55.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3315T","G10255A"],"nsp3":["T199I"]},"labels":{"aa":"nsp3: T199I"}}}]}]},{"name":"NODE_0000842","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.67"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.695337772369385}},"branch_attrs":{"mutations":{"nuc":["G26660T"],"M":["L46F"]},"labels":{"aa":"M: L46F"}},"children":[{"name":"JN.1.67","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.695337772369385}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000843","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.67.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{"nuc":["G4162A","T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.67.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.67.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.189658164978027}},"branch_attrs":{"mutations":{}}},{"name":"MZ.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"2-3 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.67.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1126A","C21654T","C21859T","C28606T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"internal_3a6e1a6e","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.898660898208618}},"branch_attrs":{"mutations":{"nuc":["G2782T"]}},"children":[{"name":"JN.1.39","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.898660898208618}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.39.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.853456020355225}},"branch_attrs":{"mutations":{"nuc":["T6913C","C21034T","G22599C","T22928C","T25631C"],"ORF3a":["V80A"],"S":["R346T","F456L"],"nsp16":["L126F"]},"labels":{"aa":"ORF3a: V80A; S: R346T, F456L; nsp16: L126F","spike_mutations":"R346T, F456L"}}},{"name":"internal_9d5b2aea","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.175326347351074}},"branch_attrs":{"mutations":{"nuc":["T111C"]}},"children":[{"name":"JN.1.39.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.39.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.5633111000061035}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.39.3","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.39.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.39.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C5512T","C21762T"],"S":["A67V"]},"labels":{"aa":"S: A67V","spike_mutations":"A67V"}}}]}]},{"name":"internal_f2ce279c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.42"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.965564727783203}},"branch_attrs":{"mutations":{"nuc":["T44C","C5581A","A28254-"],"ORF8":["I121-"]},"labels":{"aa":"ORF8: I121-"}},"children":[{"name":"JN.1.42","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.965564727783203}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.42.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.302712917327881}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"internal_ab2e7319","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.439761161804199}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.42.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.42.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.439761161804199}},"branch_attrs":{"mutations":{}}},{"name":"MS.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"MS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.42.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.217731475830078}},"branch_attrs":{"mutations":{"nuc":["C44T","A3084G","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp3":["E122G"]},"labels":{"aa":"S: S31-; nsp3: E122G","spike_mutations":"S31-"}}}]}]},{"name":"internal_3b6388a0","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.50"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["C4456T","C9298T","C21762T","G22309C","A22896C","T22930G"],"S":["A67V","L249F","H445P","F456L"]},"labels":{"aa":"S: A67V, L249F, H445P, F456L","spike_mutations":"A67V, L249F, H445P, F456L"}},"children":[{"name":"JN.1.50","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.50.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.50.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T8749G","C11704T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_33a1525b","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.50.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{"nuc":["A4884G","T4885C"],"nsp3":["N722S"]},"labels":{"aa":"nsp3: N722S"}},"children":[{"name":"JN.1.50.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.50.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.046439170837402}},"branch_attrs":{"mutations":{}}},{"name":"ME.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"ME.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.27215999999999985"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.50.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599A","T27152C"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}}]}]},{"name":"internal_3ed64198","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.53"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.891237735748291}},"branch_attrs":{"mutations":{"nuc":["C15720T"]}},"children":[{"name":"JN.1.53","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.891237735748291}},"branch_attrs":{"mutations":{}}},{"name":"internal_e83f198e","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.53.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.83420991897583}},"branch_attrs":{"mutations":{"nuc":["C583T"]}},"children":[{"name":"JN.1.53.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.53.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.83420991897583}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000852","node_attrs":{"div":132,"Nextclade_pango":{"value":"LN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C11455T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LN.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LN.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2595099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.53.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G17211A","T22928C","A22995T"],"S":["F456L","K478I"]},"labels":{"aa":"S: F456L, K478I","spike_mutations":"F456L, K478I"}}}]}]}]},{"name":"internal_a859def4","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.65"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["A5053G","C6720T","C23277T","T23629C","G25647T"],"ORF3a":["L85F"],"S":["T572I"],"nsp3":["T1334I"]},"labels":{"aa":"ORF3a: L85F; S: T572I; nsp3: T1334I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.65","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{}}},{"name":"internal_06e865f9","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.65.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{"nuc":["C5884T","A10420G","T22928C","C29149T"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.65.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.65.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.765995502471924}},"branch_attrs":{"mutations":{}}},{"name":"MF.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.733509540557861}},"branch_attrs":{"mutations":{"nuc":["T21673C","G22599C","T22981C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"MF.2","node_attrs":{"div":140,"Nextclade_pango":{"value":"MF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.65.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.500079154968262}},"branch_attrs":{"mutations":{"nuc":["C20483T","T21740C","G21753T"],"S":["S60P","W64L"],"nsp15":["S288F"]},"labels":{"aa":"S: S60P, W64L; nsp15: S288F","spike_mutations":"S60P, W64L"}}}]}]},{"name":"NODE_0000855","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.28.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{"nuc":["C5184T","C19545T","C24034T","C24370T","A29700G"],"nsp3":["P822L"]},"labels":{"aa":"nsp3: P822L"}},"children":[{"name":"JN.1.28.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.28.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.125619888305664}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000856","node_attrs":{"div":135,"Nextclade_pango":{"value":"KW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["T10084A","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"KW.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{}}},{"name":"KW.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.9318500000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3745641202332524"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A23148C"],"S":["K529T"]},"labels":{"aa":"S: K529T","spike_mutations":"K529T"}}},{"name":"NODE_0000857","node_attrs":{"div":137,"Nextclade_pango":{"value":"KW.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["G19493A","T22928C"],"S":["F456L"],"nsp14":["R485K"]},"labels":{"aa":"S: F456L; nsp14: R485K","spike_mutations":"F456L"}},"children":[{"name":"KW.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000858","node_attrs":{"div":138,"Nextclade_pango":{"value":"KW.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21846G"],"S":["T95S"]},"labels":{"aa":"S: T95S","spike_mutations":"T95S"}},"children":[{"name":"KW.1.1.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"KW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C10456T"]}}},{"name":"LG.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"LG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.28.1.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G22599C","C27600T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]}]}]}]},{"name":"internal_21507594","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.30"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.34359073638916}},"branch_attrs":{"mutations":{"nuc":["G21255T"]}},"children":[{"name":"JN.1.30","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.34359073638916}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000860","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.30.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.548327922821045}},"branch_attrs":{"mutations":{"nuc":["C228T","T7789C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.30.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.30.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.548327922821045}},"branch_attrs":{"mutations":{}}},{"name":"KU.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.693402290344238}},"branch_attrs":{"mutations":{"nuc":["A22106C","C24130T"],"S":["K182Q"]},"labels":{"aa":"S: K182Q","spike_mutations":"K182Q"}}},{"name":"internal_ef0cdfe8","node_attrs":{"div":133,"Nextclade_pango":{"value":"KU.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.124417304992676}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KU.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A3647T","C7113T","C27813A"],"ORF7b":["L20I"],"nsp3":["I310F","T1465I"]},"labels":{"aa":"ORF7b: L20I; nsp3: I310F, T1465I"}}},{"name":"KU.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G19800A","T21740C","T25264C","C27155A","C28657T"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"KU.2.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KU.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.30.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{"nuc":["C8481T","G22200A","C22432T"],"S":["G213E"],"nsp3":["P1921L"]},"labels":{"aa":"S: G213E; nsp3: P1921L","spike_mutations":"G213E"}}}]}]}]},{"name":"internal_2d4b9963","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9566845893859863}},"branch_attrs":{"mutations":{"nuc":["T18471C"]}},"children":[{"name":"JN.1.35","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.35"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.104548931121826}},"branch_attrs":{"mutations":{"nuc":["C23601A"],"S":["S680Y"]},"labels":{"aa":"S: S680Y","spike_mutations":"S680Y"}}},{"name":"internal_fdbfb6a7","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{"nuc":["G29134T"]}},"children":[{"name":"JN.1.48","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":86},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.530190944671631}},"branch_attrs":{"mutations":{}}},{"name":"internal_137393d6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.48.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.48.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T44C","C1545T","A3829G"],"nsp2":["A247V"]},"labels":{"aa":"nsp2: A247V"}}},{"name":"NODE_0000865","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T3913A","C8092T","T21740C","T22928C"],"S":["S60P","F456L"]},"labels":{"aa":"S: S60P, F456L","spike_mutations":"S60P, F456L"}},"children":[{"name":"JN.1.48.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C5547T","C25571T"],"ORF3a":["S60F"],"nsp3":["T943I"]},"labels":{"aa":"ORF3a: S60F; nsp3: T943I"}}},{"name":"internal_76eb3a6a","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C25378T","C25688T"],"ORF3a":["A99V"]},"labels":{"aa":"ORF3a: A99V"}},"children":[{"name":"JN.1.48.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"JN.1.48.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"LD.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"LD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.48.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C2295T","C23277T"],"S":["T572I"],"nsp2":["T497I"]},"labels":{"aa":"S: T572I; nsp2: T497I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"NODE_0000867","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.500879764556885}},"branch_attrs":{"mutations":{"nuc":["C27476T"],"ORF7a":["T28I"]},"labels":{"aa":"ORF7a: T28I"}},"children":[{"name":"JN.1.8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.500879764556885}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.8.3","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.8.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C203T","C13821T","C14925T"]}}},{"name":"NODE_0000868","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.438821315765381}},"branch_attrs":{"mutations":{"nuc":["A12928G"]}},"children":[{"name":"JN.1.8.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.6234030723571777}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.8.4","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G24398A"],"S":["G946R"]},"labels":{"aa":"S: G946R","spike_mutations":"G946R"}}},{"name":"NODE_0000869","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.61719274520874}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.8.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.61719274520874}},"branch_attrs":{"mutations":{}}},{"name":"KY.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.8.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T44C","A11585G"],"nsp6":["N205D"]},"labels":{"aa":"nsp6: N205D"}}}]}]}]},{"name":"internal_8d890f24","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77033805847168}},"branch_attrs":{"mutations":{"nuc":["C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"JN.1.15","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77033805847168}},"branch_attrs":{"mutations":{}}},{"name":"internal_cc2522d8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.424421787261963}},"branch_attrs":{"mutations":{"nuc":["T44C","T22928C","A25758T","A29895T","A29896G"],"ORF3a":["R122S"],"S":["F456L"]},"labels":{"aa":"ORF3a: R122S; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.15.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.424421787261963}},"branch_attrs":{"mutations":{}}},{"name":"internal_9f719b1f","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.15.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.75288200378418}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LU.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.045562267303467}},"branch_attrs":{"mutations":{"nuc":["C13381T","C19269T"]}}},{"name":"internal_29350230","node_attrs":{"div":136,"Nextclade_pango":{"value":"LU.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{"nuc":["T20865C"]}},"children":[{"name":"LU.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{}}},{"name":"LU.2.2","node_attrs":{"div":141,"Nextclade_pango":{"value":"LU.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3264T","C16375A","C22879T","A23592C","T27794A"],"ORF7b":["F13L"],"S":["Q677P"],"nsp13":["P47T"],"nsp3":["T182I"]},"labels":{"aa":"ORF7b: F13L; S: Q677P; nsp13: P47T; nsp3: T182I","spike_mutations":"Q677P"}}},{"name":"internal_00d52d40","node_attrs":{"div":137,"Nextclade_pango":{"value":"LU.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}},"children":[{"name":"LU.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LU.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.396651744842529}},"branch_attrs":{"mutations":{"nuc":["T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"LU.2.1.1","node_attrs":{"div":143,"Nextclade_pango":{"value":"LU.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.15.1.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C875T","C5826T","G7675T","T21740C","A22108C","T28474C"],"ORF9b":["L64P"],"S":["S60P","K182N"],"nsp2":["L24F"],"nsp3":["T1036I"]},"labels":{"aa":"ORF9b: L64P; S: S60P, K182N; nsp2: L24F; nsp3: T1036I","spike_mutations":"S60P, K182N"}}}]}]}]}]}]},{"name":"internal_aad99ee3","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.49"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.772427558898926}},"branch_attrs":{"mutations":{"nuc":["C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"JN.1.49","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.772427558898926}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.49.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.49.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.320776462554932}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_d6241d6f","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.49.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.515070915222168}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.49.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.49.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A1977C","A12421G"],"nsp2":["D391A"]},"labels":{"aa":"nsp2: D391A"}}},{"name":"internal_0257fb60","node_attrs":{"div":134,"Nextclade_pango":{"value":"MB.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C8917T","C21654T","T22928G","T29637A"],"ORF10":["I27K"],"S":["S31F","F456V"]},"labels":{"aa":"ORF10: I27K; S: S31F, F456V","spike_mutations":"S31F, F456V"}},"children":[{"name":"MB.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2273A","G12769A","C24418A"],"nsp2":["E490K"]},"labels":{"aa":"nsp2: E490K"}}},{"name":"NODE_0000878","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G7393T","C21627A","A22108C"],"S":["T22N","K182N"]},"labels":{"aa":"S: T22N, K182N","spike_mutations":"T22N, K182N"}},"children":[{"name":"MB.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000879","node_attrs":{"div":138,"Nextclade_pango":{"value":"MB.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C936T"],"nsp2":["T44I"]},"labels":{"aa":"nsp2: T44I"}},"children":[{"name":"MB.1.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MB.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MV.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.30217999999999995"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.49.1.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["A22995C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}}]}]}]}]}]},{"name":"NODE_0000880","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.58"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.30778169631958}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}},"children":[{"name":"JN.1.58","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.30778169631958}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.58.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.58.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.408945560455322}},"branch_attrs":{"mutations":{"nuc":["G17562T","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"JN.1.58.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.224411964416504}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"internal_971b7023","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.872320652008057}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.58.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.58.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.872320652008057}},"branch_attrs":{"mutations":{}}},{"name":"LR.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.468550205230713}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"LR.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C11259A","A19659G","T22930A","C27196T","T27484C"],"S":["F456L"],"nsp6":["T96K"]},"labels":{"aa":"S: F456L; nsp6: T96K","spike_mutations":"F456L"}}},{"name":"LR.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.58.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7851T","C16883G","G21746T","T22928G","A29700G","C29774A"],"S":["V62F","F456V"],"nsp13":["T216S"],"nsp3":["A1711V"]},"labels":{"aa":"S: V62F, F456V; nsp13: T216S; nsp3: A1711V","spike_mutations":"V62F, F456V"}}}]}]},{"name":"internal_1d876fbd","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.64"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.532392978668213}},"branch_attrs":{"mutations":{"nuc":["A6705G"],"nsp3":["N1329S"]},"labels":{"aa":"nsp3: N1329S"}},"children":[{"name":"JN.1.64","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.532392978668213}},"branch_attrs":{"mutations":{}}},{"name":"internal_444f5af1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.64.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.342892169952393}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.64.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.64.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.342892169952393}},"branch_attrs":{"mutations":{}}},{"name":"MD.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"MD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C8664T","T22928G","T23773C"],"S":["F456V"],"nsp4":["T37I"]},"labels":{"aa":"S: F456V; nsp4: T37I","spike_mutations":"F456V"}}},{"name":"internal_4c0e0196","node_attrs":{"div":131,"Nextclade_pango":{"value":"MD.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.914387226104736}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"MD.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"MD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.914387226104736}},"branch_attrs":{"mutations":{}}},{"name":"MD.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"MD.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["A23598G"],"S":["K679R"]},"labels":{"aa":"S: K679R","spike_mutations":"K679R"}}}]},{"name":"internal_c313b448","node_attrs":{"div":134,"Nextclade_pango":{"value":"MD.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T44C","C1060T","C9319T","C28657T"]}},"children":[{"name":"MD.3","node_attrs":{"div":134,"Nextclade_pango":{"value":"MD.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"MD.3.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MD.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.64.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10138T","T22928C","C25708T"],"ORF3a":["L106F"],"S":["F456L"]},"labels":{"aa":"ORF3a: L106F; S: F456L","spike_mutations":"F456L"}}}]}]}]},{"name":"internal_b5311fc8","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.229282379150391}},"branch_attrs":{"mutations":{"nuc":["C26894T"]}},"children":[{"name":"JN.1.26","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.26"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.005563735961914}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"internal_b1d7a4e8","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9326608180999756}},"branch_attrs":{"mutations":{"nuc":["C25680T"]}},"children":[{"name":"JN.1.14","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.02389"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.14"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.469202518463135}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"JN.1.27","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.27"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.131450176239014}},"branch_attrs":{"mutations":{"nuc":["T44C","C4202T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}},{"name":"internal_7519c261","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{"nuc":["G24821T"],"S":["A1087S"]},"labels":{"aa":"S: A1087S","spike_mutations":"A1087S"}},"children":[{"name":"JN.1.13","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.721928119659424}},"branch_attrs":{"mutations":{}}},{"name":"internal_ecc212c8","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.13.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T21738C","G22599C"],"S":["F59S","R346T"]},"labels":{"aa":"S: F59S, R346T","spike_mutations":"F59S, R346T"}},"children":[{"name":"JN.1.13.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{}}},{"name":"internal_d408fed4","node_attrs":{"div":134,"Nextclade_pango":{"value":"KS.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KS.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KS.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["T21622C","C23595T"],"S":["T678I"]},"labels":{"aa":"S: T678I","spike_mutations":"T678I"}}},{"name":"KS.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KS.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.105812072753906}},"branch_attrs":{"mutations":{"nuc":["C6701T","C19716T","C21627A"],"S":["T22N"],"nsp3":["L1328F"]},"labels":{"aa":"S: T22N; nsp3: L1328F","spike_mutations":"T22N"}}},{"name":"KS.1.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KS.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11125C","T23487C"],"S":["V642A"]},"labels":{"aa":"S: V642A","spike_mutations":"V642A"}}},{"name":"KS.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.13.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.062829494476318}},"branch_attrs":{"mutations":{}}}]}]}]}]}]},{"name":"internal_fbd16f64","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.097977638244629}},"branch_attrs":{"mutations":{"nuc":["C25566T"]}},"children":[{"name":"internal_7823bc83","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.57"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11947G","G17122T"],"nsp13":["A296S"]},"labels":{"aa":"nsp13: A296S"}},"children":[{"name":"JN.1.57.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.57.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{"nuc":["A11342G","T21740C"],"S":["S60P"],"nsp6":["I124V"]},"labels":{"aa":"S: S60P; nsp6: I124V","spike_mutations":"S60P"}}},{"name":"JN.1.57","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.57"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.3090105056762695}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_dd754174","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{"nuc":["C23277T","G25012T"],"S":["T572I","E1150D"]},"labels":{"aa":"S: T572I, E1150D","spike_mutations":"T572I, E1150D"}},"children":[{"name":"JN.1.7","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7309727668762207}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.7.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["G18155T"],"nsp14":["C39F"]},"labels":{"aa":"nsp14: C39F"}}},{"name":"JN.1.7.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.2874226570129395}},"branch_attrs":{"mutations":{"nuc":["G24A","T25G","A30G","C32-","C33-","A34-","A35-","C36-","C37-","A38-","A39-","C40-","T41-","T42-","T43-","T44-","G45-","A46-","T47-","C48-","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.7.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.08313"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.566636085510254}},"branch_attrs":{"mutations":{"nuc":["G22599A"],"S":["R346K"]},"labels":{"aa":"S: R346K","spike_mutations":"R346K"}}},{"name":"JN.1.7.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6906843185424805}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"JN.1.7.7","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.1756510734558105}},"branch_attrs":{"mutations":{"nuc":["A21137G"],"nsp16":["K160R"]},"labels":{"aa":"nsp16: K160R"}}},{"name":"JN.1.7.6","node_attrs":{"div":136,"Nextclade_pango":{"value":"JN.1.7.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5090T","T21740C","C24370T","C28163T","C28957T"],"S":["S60P"],"nsp3":["P791S"]},"labels":{"aa":"S: S60P; nsp3: P791S","spike_mutations":"S60P"}}},{"name":"JN.1.7.9","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G347A","C1057T","C7834T","T22930A"],"S":["F456L"],"nsp1":["V28I"]},"labels":{"aa":"S: F456L; nsp1: V28I","spike_mutations":"F456L"}}},{"name":"NODE_0000894","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2695T","C7840T","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-","T22930A"],"S":["N185-","F186-","K187-","N188-","L189-","F456L"]},"labels":{"aa":"S: N185-, F186-, K187-, N188-, L189-, F456L","spike_mutations":"N185-, F186-, K187-, N188-, L189-, F456L"}},"children":[{"name":"JN.1.7.8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.7.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000895","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.7.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C29367T"],"N":["P365L"]},"labels":{"aa":"N: P365L"}},"children":[{"name":"MQ.2","node_attrs":{"div":140,"Nextclade_pango":{"value":"MQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2939T","A13288G","C14599T","C23595T","T28570C"],"ORF9b":["V96A"],"S":["T678I"],"nsp3":["P74S"]},"labels":{"aa":"ORF9b: V96A; S: T678I; nsp3: P74S","spike_mutations":"T678I"}}},{"name":"MQ.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C16954T","C21846T","G22599C","T24499C"],"S":["T95I","R346T"]},"labels":{"aa":"S: T95I, R346T","spike_mutations":"T95I, R346T"}}}]}]},{"name":"internal_f4c039b9","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{"nuc":["C10448T"],"nsp5":["H132Y"]},"labels":{"aa":"nsp5: H132Y"}},"children":[{"name":"JN.1.7.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.7.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.3473029136657715}},"branch_attrs":{"mutations":{}}},{"name":"LK.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.04395"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3773T","C8140T","G11083T","A22896C"],"S":["H445P"],"nsp3":["R352C"],"nsp6":["L37F"]},"labels":{"aa":"S: H445P; nsp3: R352C; nsp6: L37F","spike_mutations":"H445P"}}},{"name":"internal_4ab0eaf4","node_attrs":{"div":133,"Nextclade_pango":{"value":"LK.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LK.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"LK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.993257522583008}},"branch_attrs":{"mutations":{}}},{"name":"LK.2.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.95433"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.7.5.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21255C","T22925G","C23202A","T23569C"],"S":["S455A","T547K"]},"labels":{"aa":"S: S455A, T547K","spike_mutations":"S455A, T547K"}}}]}]}]}]},{"name":"internal_1e3e","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7119815349578857}},"branch_attrs":{"mutations":{"nuc":["C774T"],"nsp1":["T170I"]},"labels":{"aa":"nsp1: T170I"}},"children":[{"name":"JN.1.4","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.7119815349578857}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.4.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.776749610900879}},"branch_attrs":{"mutations":{"nuc":["A23523T"],"S":["E654V"]},"labels":{"aa":"S: E654V","spike_mutations":"E654V"}}},{"name":"JN.1.4.4","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.743699073791504}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"JN.1.4.8","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["T13578C","T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}}},{"name":"internal_974a67a9","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}},"children":[{"name":"JN.1.4.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.924506187438965}},"branch_attrs":{"mutations":{}}},{"name":"KQ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"KQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.165515899658203}},"branch_attrs":{"mutations":{"nuc":["T44C","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_3e1a35d0","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-2.8164443969726562}},"branch_attrs":{"mutations":{"nuc":["T18453C"]}},"children":[{"name":"JN.1.4.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.092732906341553}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.4.9","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.036890983581543}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"internal_c7cd4193","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"JN.1.4.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.373999118804932}},"branch_attrs":{"mutations":{}}},{"name":"LL.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T44C","T22930A","C23601T","C29311T"],"S":["F456L","S680F"]},"labels":{"aa":"S: F456L, S680F","spike_mutations":"F456L, S680F"}}}]},{"name":"internal_ccc286fe","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{"nuc":["C28201T"],"ORF8":["S103L"]},"labels":{"aa":"ORF8: S103L"}},"children":[{"name":"JN.1.4.5","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.4685325622558594}},"branch_attrs":{"mutations":{}}},{"name":"KV.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"KV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.280522346496582}},"branch_attrs":{"mutations":{"nuc":["C3177T","C11956T","C23277T"],"S":["T572I"],"nsp3":["P153L"]},"labels":{"aa":"S: T572I; nsp3: P153L","spike_mutations":"T572I"}}},{"name":"KV.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["A2356T","C23601T","C28948T"],"S":["S680F"]},"labels":{"aa":"S: S680F","spike_mutations":"S680F"}}}]}]},{"name":"internal_e935921c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.782619953155518}},"branch_attrs":{"mutations":{"nuc":["G25445A"],"ORF3a":["G18D"]},"labels":{"aa":"ORF3a: G18D"}},"children":[{"name":"JN.1.4.7","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.782619953155518}},"branch_attrs":{"mutations":{}}},{"name":"LE.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.02389"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C7423T","G22104T","A22600C","C27635T"],"ORF7a":["S81L"],"S":["G181V","R346S"]},"labels":{"aa":"ORF7a: S81L; S: G181V, R346S","spike_mutations":"G181V, R346S"}}},{"name":"NODE_0000904","node_attrs":{"div":131,"Nextclade_pango":{"value":"LE.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.769268035888672}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LE.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.769268035888672}},"branch_attrs":{"mutations":{}}},{"name":"LE.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.145790100097656}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}}},{"name":"LE.1.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"LE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C15656T","A22474C"],"S":["K304N"],"nsp12":["T739I"]},"labels":{"aa":"S: K304N; nsp12: T739I","spike_mutations":"K304N"}}},{"name":"NODE_0000905","node_attrs":{"div":137,"Nextclade_pango":{"value":"LE.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10615T","C21812G","C23638T","C27752T","G29254T"],"ORF7a":["T120I"],"S":["L84V"]},"labels":{"aa":"ORF7a: T120I; S: L84V","spike_mutations":"L84V"}},"children":[{"name":"LE.1.3.1","node_attrs":{"div":143,"Nextclade_pango":{"value":"LE.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T7396C","C11653T","C22079A","T22928C","C27590T","T29194C"],"ORF7a":["A66V"],"S":["Q173K","F456L"]},"labels":{"aa":"ORF7a: A66V; S: Q173K, F456L","spike_mutations":"Q173K, F456L"}}},{"name":"LE.1.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.4.7.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}}]}]}]}]},{"name":"internal_31dddbfd","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.5280258655548096}},"branch_attrs":{"mutations":{"nuc":["C1762A","C11747T"],"nsp2":["F319L"]},"labels":{"aa":"nsp2: F319L"}},"children":[{"name":"JN.1.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-11-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.5280258655548096}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.1.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.900146961212158}},"branch_attrs":{"mutations":{"nuc":["T3488C","G22104A"],"S":["G181E"]},"labels":{"aa":"S: G181E","spike_mutations":"G181E"}}},{"name":"JN.1.1.8","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21984999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C850T","G6513T","A22896C","T22930A"],"S":["H445P","F456L"],"nsp3":["S1265I"]},"labels":{"aa":"S: H445P, F456L; nsp3: S1265I","spike_mutations":"H445P, F456L"}}},{"name":"NODE_0000907","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.3","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.735454559326172}},"branch_attrs":{"mutations":{}}},{"name":"LT.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T44C","T6095C","C6541T","C21911T","C22088T","T22928G"],"S":["L176F","F456V"]},"labels":{"aa":"S: L176F, F456V","spike_mutations":"L176F, F456V"}}}]},{"name":"internal_e3b87428","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.64257287979126}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"JN.1.1.7","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.64257287979126}},"branch_attrs":{"mutations":{}}},{"name":"LC.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.335469722747803}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"internal_d4b79143","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972496032714844}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.1.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972496032714844}},"branch_attrs":{"mutations":{}}},{"name":"internal_3e2357c4","node_attrs":{"div":132,"Nextclade_pango":{"value":"KZ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.621585369110107}},"branch_attrs":{"mutations":{"nuc":["G16741T"],"nsp13":["V169F"]},"labels":{"aa":"nsp13: V169F"}},"children":[{"name":"KZ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"KZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.621585369110107}},"branch_attrs":{"mutations":{}}},{"name":"internal_564aef39","node_attrs":{"div":133,"Nextclade_pango":{"value":"KZ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KZ.1.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695219993591309}},"branch_attrs":{"mutations":{}}},{"name":"KZ.1.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KZ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.6.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4901A","C23277T"],"S":["T572I"],"nsp3":["L728I"]},"labels":{"aa":"S: T572I; nsp3: L728I","spike_mutations":"T572I"}}}]}]}]},{"name":"NODE_0000912","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.3227221965789795}},"branch_attrs":{"mutations":{"nuc":["C9142T"]}},"children":[{"name":"JN.1.1.10","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.10"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.885519981384277}},"branch_attrs":{"mutations":{"nuc":["C23557T"]}}},{"name":"JN.1.1.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.391621112823486}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"JN.1.1.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.850338935852051}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"JN.1.1.9","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G2035A"]}}},{"name":"NODE_0000913","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.1.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.768957138061523}},"branch_attrs":{"mutations":{}}},{"name":"KR.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"KR.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}}},{"name":"KR.5","node_attrs":{"div":137,"Nextclade_pango":{"value":"KR.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["T21C","T44C","C2189T","C6525T","A23746G"],"nsp2":["L462F"],"nsp3":["T1269I"]},"labels":{"aa":"nsp2: L462F; nsp3: T1269I"}}},{"name":"NODE_0000914","node_attrs":{"div":136,"Nextclade_pango":{"value":"KR.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18083C","A18600G","C22214G","T24022C"],"S":["Q218E"],"nsp14":["I15T"]},"labels":{"aa":"S: Q218E; nsp14: I15T","spike_mutations":"Q218E"}},"children":[{"name":"KR.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KR.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"KR.4.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"KR.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2408299999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":11.111},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C6472T","C12890T","T22928C","A22995C","G25244T","C25710T"],"S":["F456L","K478T","V1228L"]},"labels":{"aa":"S: F456L, K478T, V1228L","spike_mutations":"F456L, K478T, V1228L"}}}]},{"name":"NODE_0000915","node_attrs":{"div":134,"Nextclade_pango":{"value":"KR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{"nuc":["T22928C","C28498T"],"ORF9b":["T72I"],"S":["F456L"]},"labels":{"aa":"ORF9b: T72I; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"KR.1.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G23610A"],"S":["R683Q"]},"labels":{"aa":"S: R683Q","spike_mutations":"R683Q"}}},{"name":"KR.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.750261306762695}},"branch_attrs":{"mutations":{}}},{"name":"KR.1.3","node_attrs":{"div":143,"Nextclade_pango":{"value":"KR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T616A","C875T","C1628A","C6395T","A7301G","T14619C","T21740C","A22472C","C23533T"],"S":["S60P","K304Q"],"nsp2":["L24F","Q275K"],"nsp3":["I1528V"]},"labels":{"aa":"S: S60P, K304Q; nsp2: L24F, Q275K; nsp3: I1528V","spike_mutations":"S60P, K304Q"}}},{"name":"KR.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.1.5.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.076402187347412}},"branch_attrs":{"mutations":{"nuc":["T21737C"],"S":["F59L"]},"labels":{"aa":"S: F59L","spike_mutations":"F59L"}}}]}]}]}]},{"name":"NODE_0000916","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.056101322174072}},"branch_attrs":{"mutations":{"nuc":["G22111T"],"S":["Q183H"]},"labels":{"aa":"S: Q183H","spike_mutations":"Q183H"}},"children":[{"name":"JN.1.9","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.056101322174072}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.9.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6075029373168945}},"branch_attrs":{"mutations":{"nuc":["C9693T","C23277T"],"S":["T572I"],"nsp4":["A380V"]},"labels":{"aa":"S: T572I; nsp4: A380V","spike_mutations":"T572I"}}},{"name":"internal_81193a6c","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.9.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.143343448638916}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.9.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.9.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.143343448638916}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000918","node_attrs":{"div":131,"Nextclade_pango":{"value":"LB.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9964091777801514}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","T22928C"],"S":["S31-","F456L"]},"labels":{"aa":"S: S31-, F456L","spike_mutations":"S31-, F456L"}},"children":[{"name":"LB.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C7788A","T11269C","A22252G","G24872T"],"S":["V1104L"],"nsp3":["A1690D"]},"labels":{"aa":"S: V1104L; nsp3: A1690D","spike_mutations":"V1104L"}}},{"name":"LB.1","node_attrs":{"div":131,"Nextclade_pango":{"value":"LB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.9964091777801514}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.6","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.695721626281738}},"branch_attrs":{"mutations":{"nuc":["C7564T","T7814C","A23572G"],"S":["I670M"],"nsp3":["S1699P"]},"labels":{"aa":"S: I670M; nsp3: S1699P","spike_mutations":"I670M"}}},{"name":"LB.1.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A1096G","C18329T","T18909C","C24989T"],"S":["L1143F"],"nsp14":["T97I"]},"labels":{"aa":"S: L1143F; nsp14: T97I","spike_mutations":"L1143F"}}},{"name":"LB.1.8","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.729191780090332}},"branch_attrs":{"mutations":{"nuc":["A2618G","A13015G","-21653T","-21654C","-21655T"],"S":["-31S"],"nsp2":["I605V"]},"labels":{"aa":"S: -31S; nsp2: I605V","spike_mutations":"-31S"}}},{"name":"LB.1.9","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.2408299999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C15960T","G20931T","A22995C","T29194C"],"S":["K478T"]},"labels":{"aa":"S: K478T","spike_mutations":"K478T"}}},{"name":"NODE_0000919","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.558164596557617}},"branch_attrs":{"mutations":{"nuc":["C4683T"],"nsp3":["A655V"]},"labels":{"aa":"nsp3: A655V"}},"children":[{"name":"LB.1.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.558164596557617}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.4.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["G22132T","A27809G"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}},{"name":"LB.1.4.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LB.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.4.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C14925T","G24095T","C25603T","C27012T","C28312T"],"ORF9b":["S10F"],"S":["A845S"]},"labels":{"aa":"ORF9b: S10F; S: A845S","spike_mutations":"A845S"}}}]},{"name":"NODE_0000920","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{"nuc":["G19669A"],"nsp15":["G17R"]},"labels":{"aa":"nsp15: G17R"}},"children":[{"name":"LB.1.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"LB.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.624283790588379}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.2.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.662420749664307}},"branch_attrs":{"mutations":{"nuc":["G22131C"],"S":["R190T"]},"labels":{"aa":"S: R190T","spike_mutations":"R190T"}}},{"name":"LB.1.2.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.9794921875}},"branch_attrs":{"mutations":{"nuc":["C22075T","C23029T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"LB.1.2.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.2.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C4021T","A4967T","T22085C"],"S":["F175L"],"nsp3":["I750F"]},"labels":{"aa":"S: F175L; nsp3: I750F","spike_mutations":"F175L"}}}]},{"name":"internal_1a132a5b","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{"nuc":["T44C","C4784T","G21123T"],"nsp3":["L689F"]},"labels":{"aa":"nsp3: L689F"}},"children":[{"name":"LB.1.7","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.142344951629639}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.7.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C16887T","T23600C"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"LB.1.7.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LB.1.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T11968C","T16692C","A22005C","G29781T"],"S":["N148T"]},"labels":{"aa":"S: N148T","spike_mutations":"N148T"}}},{"name":"LB.1.7.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.7.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21662T","C28201T"],"ORF8":["S103L"],"S":["R34C"]},"labels":{"aa":"ORF8: S103L; S: R34C","spike_mutations":"R34C"}}}]},{"name":"NODE_0000922","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{"nuc":["T2G","C18131T"],"nsp14":["T31I"]},"labels":{"aa":"nsp14: T31I"}},"children":[{"name":"LB.1.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"LB.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.111878395080566}},"branch_attrs":{"mutations":{}}},{"name":"LB.1.3.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LB.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.438388824462891}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","A22896C","C27476T","C29409T"],"N":["T379I"],"ORF7a":["T28I"],"S":["H445P"],"nsp1":["V84-","M85-"]},"labels":{"aa":"N: T379I; ORF7a: T28I; S: H445P; nsp1: V84-, M85-","spike_mutations":"H445P"}}},{"name":"LB.1.3.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"LB.1.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.472050666809082}},"branch_attrs":{"mutations":{"nuc":["C9163T","A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"internal_45263acb","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["C24844T"]}},"children":[{"name":"LB.1.3.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LB.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{}}},{"name":"MH.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"MH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.9.2.1.3.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]},{"name":"internal_eceb5d54","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.925825357437134}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.16","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-3.925825357437134}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.16.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.347440719604492}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000925","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.68872594833374}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","spike_mutations":"Q493E"}},"children":[{"name":"JN.1.16.5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.16.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.004867076873779}},"branch_attrs":{"mutations":{"nuc":["T44C","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_c66af82a","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.16.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A532G","G1463A","T27568A","T27569A","T27570A"],"ORF7a":["F59K"],"nsp2":["G220S"]},"labels":{"aa":"ORF7a: F59K; nsp2: G220S"}},"children":[{"name":"JN.1.16.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.16.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{}}},{"name":"MT.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"MT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T21653C","C29108T"],"N":["P279S"],"S":["S31P"]},"labels":{"aa":"N: P279S; S: S31P","spike_mutations":"S31P"}}}]}]},{"name":"internal_dc847259","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.413978576660156}},"branch_attrs":{"mutations":{"nuc":["C4777T"]}},"children":[{"name":"JN.1.16.2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.413978576660156}},"branch_attrs":{"mutations":{}}},{"name":"internal_2ee2c28f","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.16.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"LA.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.685048580169678}},"branch_attrs":{"mutations":{"nuc":["T22599C"]}}},{"name":"LA.2","node_attrs":{"div":131,"Nextclade_pango":{"value":"LA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.04741999999999978"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.458614826202393}},"branch_attrs":{"mutations":{"S":["T346I"]},"labels":{"aa":"S: T346I","spike_mutations":"T346I"}}}]}]},{"name":"internal_acb00454","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.084030628204346}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.16.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.084030628204346}},"branch_attrs":{"mutations":{}}},{"name":"LF.2","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.0966057777404785}},"branch_attrs":{"mutations":{"nuc":["A1005G","T21653-","C21654-","T21655-","T25942C"],"ORF3a":["Y184H"],"S":["S31-"],"nsp2":["K67R"]},"labels":{"aa":"ORF3a: Y184H; S: S31-; nsp2: K67R","spike_mutations":"S31-"}}},{"name":"LF.5","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G17562T","A21659G","A22115G","C28660T"],"S":["T33A","N185D"]},"labels":{"aa":"S: T33A, N185D","spike_mutations":"T33A, N185D"}}},{"name":"LF.6","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1T","T3172G","T17859C"]}}},{"name":"LF.7","node_attrs":{"div":143,"Nextclade_pango":{"value":"LF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21767999999999987"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":50.174},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.817229820305529"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C5239T","C7869T","C8818T","G12892A","T16600C","C21627A","T21653C","A22107G","G22132T","C22792T","A22893G","C22993T","T28297C"],"ORF9b":["I5T"],"S":["T22N","S31P","K182R","R190S","K444R"],"nsp3":["S1717L"]},"labels":{"aa":"ORF9b: I5T; S: T22N, S31P, K182R, R190S, K444R; nsp3: S1717L","spike_mutations":"T22N, S31P, K182R, R190S, K444R"}}},{"name":"internal_38868e71","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C13368T","G29427A"],"N":["R385K"],"nsp10":["T115I"]},"labels":{"aa":"N: R385K; nsp10: T115I"}},"children":[{"name":"LF.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.301711559295654}},"branch_attrs":{"mutations":{}}},{"name":"LF.4.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G1820A","G8824A","T21653-","C21654-","T21655-","C27978T"],"ORF8":["Q29*"],"S":["S31-"],"nsp2":["G339S"]},"labels":{"aa":"ORF8: Q29*; S: S31-; nsp2: G339S","spike_mutations":"S31-"}}}]},{"name":"NODE_0000931","node_attrs":{"div":131,"Nextclade_pango":{"value":"LF.9"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6508469581604}},"branch_attrs":{"mutations":{"nuc":["T21740C"],"S":["S60P"]},"labels":{"aa":"S: S60P","spike_mutations":"S60P"}},"children":[{"name":"LF.9","node_attrs":{"div":131,"Nextclade_pango":{"value":"LF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6508469581604}},"branch_attrs":{"mutations":{}}},{"name":"LF.9.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.9.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"3-4 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.9.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.385717391967773}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}}]},{"name":"internal_9a6996c4","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{"nuc":["G4067A","C6573T"],"nsp3":["A450T","S1285F"]},"labels":{"aa":"nsp3: A450T, S1285F"}},"children":[{"name":"LF.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.6880269050598145}},"branch_attrs":{"mutations":{}}},{"name":"internal_8bf5c852","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{"nuc":["C16551T","C18912T","C25350T"],"S":["P1263L"]},"labels":{"aa":"S: P1263L","spike_mutations":"P1263L"}},"children":[{"name":"LF.1.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.824590682983398}},"branch_attrs":{"mutations":{}}},{"name":"LF.1.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.469202518463135}},"branch_attrs":{"mutations":{"nuc":["T19209C","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}}]}]},{"name":"internal_82b8c9cf","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5581A","C7594T","C13119T","A28254-"],"ORF8":["I121-"],"nsp10":["A32V"]},"labels":{"aa":"ORF8: I121-; nsp10: A32V"}},"children":[{"name":"LF.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"LF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"internal_658c61c4","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A22896C"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}},"children":[{"name":"LF.3.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LF.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"LF.3.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LF.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13860T","C18888T","C24989T"],"S":["L1143F"]},"labels":{"aa":"S: L1143F","spike_mutations":"L1143F"}}}]}]},{"name":"NODE_0000936","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C3244T","C9169T","A18432T","G22021C","C27110T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}},"children":[{"name":"LF.8","node_attrs":{"div":135,"Nextclade_pango":{"value":"LF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000937","node_attrs":{"div":136,"Nextclade_pango":{"value":"LF.8.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}},"children":[{"name":"LF.8.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"LF.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T18229C"],"nsp14":["Y64H"]},"labels":{"aa":"nsp14: Y64H"}}},{"name":"LF.8.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LF.8.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.16.1.8.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C13436T","C21627A"],"S":["T22N"],"nsp10":["L138F"]},"labels":{"aa":"S: T22N; nsp10: L138F","spike_mutations":"T22N"}}}]}]}]}]},{"name":"internal_76e5b03a","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.106708526611328}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"JN.1.18","node_attrs":{"div":129,"Nextclade_pango":{"value":"JN.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.106708526611328}},"branch_attrs":{"mutations":{}}},{"name":"JN.1.18.8","node_attrs":{"div":135,"Nextclade_pango":{"value":"JN.1.18.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.8"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C2334T","C12823T","T15357C","C19983T","C20483T","T21613C","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp15":["S288F"],"nsp2":["A510V"]},"labels":{"aa":"S: S31-; nsp15: S288F; nsp2: A510V","spike_mutations":"S31-"}}},{"name":"internal_f4c6ea83","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.95346736907959}},"branch_attrs":{"mutations":{"nuc":["T22930A"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.5","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.95346736907959}},"branch_attrs":{"mutations":{}}},{"name":"LS.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.5.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G3085T","G8015A","G9049A","T21644C","G22113C","A22115-","A22116-","T22117-","T22118-","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-","A22125-","T22126-","C22127-","T22128-","T22129-"],"S":["Y28H","G184-","N185-","F186-","K187-","N188-","L189A"],"nsp3":["E122D","A1766T"]},"labels":{"aa":"S: Y28H, G184-, N185-, F186-, K187-, N188-, L189A; nsp3: E122D, A1766T","spike_mutations":"Y28H, G184-, N185-, F186-, K187-, N188-, L189A"}}}]},{"name":"internal_727447c5","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.18.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{"nuc":["T22930G","T23036C","T27380C"],"ORF6":["I60T"],"S":["F456L"]},"labels":{"aa":"ORF6: I60T; S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.4","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.18.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.6886067390441895}},"branch_attrs":{"mutations":{}}},{"name":"LH.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"LH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A5562C","C9565T","A22151G","C22314A","C27247T"],"S":["I197V","P251H"],"nsp3":["E948A"]},"labels":{"aa":"S: I197V, P251H; nsp3: E948A","spike_mutations":"I197V, P251H"}}},{"name":"LH.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.4.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.221216201782227}},"branch_attrs":{"mutations":{"nuc":["G2075A","A22107T"],"S":["K182I"],"nsp2":["G424S"]},"labels":{"aa":"S: K182I; nsp2: G424S","spike_mutations":"K182I"}}}]},{"name":"internal_bd4d8b79","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.8283514976501465}},"branch_attrs":{"mutations":{"nuc":["T22928G"],"S":["F456V"]},"labels":{"aa":"S: F456V","spike_mutations":"F456V"}},"children":[{"name":"JN.1.18.3","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.8283514976501465}},"branch_attrs":{"mutations":{}}},{"name":"internal_99dab91a","node_attrs":{"div":133,"Nextclade_pango":{"value":"MA.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.243719577789307}},"branch_attrs":{"mutations":{"nuc":["C13620T","T21653-","C21654-","T21655-","G22132T","A29664G"],"ORF10":["N36S"],"S":["S31-","R190S"]},"labels":{"aa":"ORF10: N36S; S: S31-, R190S","spike_mutations":"S31-, R190S"}},"children":[{"name":"MA.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"MA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.795657634735107}},"branch_attrs":{"mutations":{"nuc":["C27259A"]}}},{"name":"internal_e051ff9e","node_attrs":{"div":136,"Nextclade_pango":{"value":"MA.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["A11749G","A23901C","C27649T"],"S":["E780A"]},"labels":{"aa":"S: E780A","spike_mutations":"E780A"}},"children":[{"name":"MA.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"MA.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3794899999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"MA.1.1.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MA.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3926199999999998"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":11.111},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.3.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C21998T","A22896C","G28048T"],"ORF8":["R52I"],"S":["-144Y","H146-","H445P"]},"labels":{"aa":"ORF8: R52I; S: -144Y, H146-, H445P","spike_mutations":"-144Y, H146-, H445P"}}}]}]}]},{"name":"internal_41b1acec","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.4456329345703125}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}},"children":[{"name":"JN.1.18.1","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.4456329345703125}},"branch_attrs":{"mutations":{}}},{"name":"LQ.3","node_attrs":{"div":131,"Nextclade_pango":{"value":"LQ.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.3"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C5547T"],"nsp3":["T943I"]},"labels":{"aa":"nsp3: T943I"}}},{"name":"internal_7901df09","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.520936012268066}},"branch_attrs":{"mutations":{"nuc":["C14220T"]}},"children":[{"name":"LQ.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"LQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A812G","T21877C","C23230A"],"S":["N556K"],"nsp2":["T3A"]},"labels":{"aa":"S: N556K; nsp2: T3A","spike_mutations":"N556K"}}},{"name":"internal_a0a78f62","node_attrs":{"div":132,"Nextclade_pango":{"value":"LQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"LQ.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"LQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.992856502532959}},"branch_attrs":{"mutations":{}}},{"name":"LQ.1.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"LQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.1.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.721512794494629}},"branch_attrs":{"mutations":{"nuc":["C22377A"],"S":["P272H"]},"labels":{"aa":"S: P272H","spike_mutations":"P272H"}}}]}]}]},{"name":"internal_01daa250","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.106212139129639}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"internal_9ed4ff46","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{"nuc":["A1900G","C21627A","G25340T"],"S":["T22N","D1260Y"]},"labels":{"aa":"S: T22N, D1260Y","spike_mutations":"T22N, D1260Y"}},"children":[{"name":"JN.1.18.7","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-7.741044044494629}},"branch_attrs":{"mutations":{}}},{"name":"MN.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.7.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C20T","T3055C","C17518T","G21800T","C22082T","G23628A"],"S":["D80Y","P174S","S689N"],"nsp13":["L428F"]},"labels":{"aa":"S: D80Y, P174S, S689N; nsp13: L428F","spike_mutations":"D80Y, P174S, S689N"}}}]},{"name":"NODE_0000949","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.172158718109131}},"branch_attrs":{"mutations":{"nuc":["T22928C"],"S":["F456L"]},"labels":{"aa":"S: F456L","spike_mutations":"F456L"}},"children":[{"name":"JN.1.18.6","node_attrs":{"div":131,"Nextclade_pango":{"value":"JN.1.18.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.172158718109131}},"branch_attrs":{"mutations":{}}},{"name":"LY.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G8C","C2143T","C6270T","G9968A","G22111T"],"S":["Q183H"],"nsp3":["T1184M"],"nsp4":["A472T"]},"labels":{"aa":"S: Q183H; nsp3: T1184M; nsp4: A472T","spike_mutations":"Q183H"}}},{"name":"LY.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"LY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.6.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.744548320770264}},"branch_attrs":{"mutations":{"nuc":["T21756A","A22110C","T28693C"],"S":["F65Y","Q183P"]},"labels":{"aa":"S: F65Y, Q183P","spike_mutations":"F65Y, Q183P"}}},{"name":"NODE_0000950","node_attrs":{"div":133,"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4331T","T22321C"]}},"children":[{"name":"NODE_0000951","node_attrs":{"div":134,"Nextclade_pango":{"value":"LZ.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["A3941G"],"nsp3":["K408E"]},"labels":{"aa":"nsp3: K408E"}},"children":[{"name":"LZ.2.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"LZ.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"2-3 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C29642T"],"ORF10":["Q29*"]},"labels":{"aa":"ORF10: Q29*"}}},{"name":"LZ.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"LZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T2032C","C19041T"]}}}]},{"name":"internal_24bd909c","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.18.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"nuc":["C22928T"]}},"children":[{"name":"JN.1.18.2","node_attrs":{"div":134,"Nextclade_pango":{"value":"JN.1.18.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.14224"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":88},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5525967162870884"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.75352668762207}},"branch_attrs":{"mutations":{"S":["L456F"]},"labels":{"aa":"S: L456F","spike_mutations":"L456F"}}},{"name":"internal_41eb7227","node_attrs":{"div":138,"Nextclade_pango":{"value":"LZ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["A2483G","T22930A","T23377C","G28727A"],"N":["A152T"],"nsp2":["I560V"]},"labels":{"aa":"N: A152T; nsp2: I560V"}},"children":[{"name":"LZ.1.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"LZ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C22211T","A24936G","C27011T"],"S":["P217S","N1125S"]},"labels":{"aa":"S: P217S, N1125S","spike_mutations":"P217S, N1125S"}}},{"name":"LZ.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.18.2.1"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]},{"name":"internal_d11ee9b2","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.858034133911133}},"branch_attrs":{"mutations":{"nuc":["G17334T","G24872T"],"S":["V1104L"]},"labels":{"aa":"S: V1104L","spike_mutations":"V1104L"}},"children":[{"name":"JN.1.11","node_attrs":{"div":130,"Nextclade_pango":{"value":"JN.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"1.03082"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":87},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.3729573686780503"},"clade_display":{"value":"24A (JN.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11"},"clade_nextstrain":{"value":"24A"},"clade_membership":{"value":"24A"},"placement_prior":{"value":-4.858034133911133}},"branch_attrs":{"mutations":{}}},{"name":"internal_d7a2940b","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.11.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{"nuc":["C7113T","T22928C"],"S":["F456L"],"nsp3":["T1465I"]},"labels":{"aa":"S: F456L; nsp3: T1465I","clade":"24B","spike_mutations":"F456L"}},"children":[{"name":"JN.1.11.1","node_attrs":{"div":132,"Nextclade_pango":{"value":"JN.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-01-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299666881561279}},"branch_attrs":{"mutations":{}}},{"name":"KP.6","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.04741999999999978"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-6.00890588760376}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}},{"name":"KP.5","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.512089252471924}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"NODE_0000956","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{"nuc":["C6070T"]}},"children":[{"name":"KP.4","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":89},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.327715873718262}},"branch_attrs":{"mutations":{}}},{"name":"internal_181bd2e5","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"internal_8b5f88a3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{"nuc":["C19884T"]}},"children":[{"name":"KP.4.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.726853847503662}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22334A"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.4.1.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.27333999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7741516492587035"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T4408C","C22883G"],"S":["L441V"]},"labels":{"aa":"S: L441V","spike_mutations":"L441V"}}},{"name":"KP.4.1.3","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A2057G","A5245G","T21653-","C21654-","T21655-","C25413T"],"S":["S31-"],"nsp2":["M418V"]},"labels":{"aa":"S: S31-; nsp2: M418V","spike_mutations":"S31-"}}}]},{"name":"internal_5bd79732","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{"nuc":["A22122G"],"S":["K187R"]},"labels":{"aa":"S: K187R","spike_mutations":"K187R"}},"children":[{"name":"KP.4.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.886738300323486}},"branch_attrs":{"mutations":{}}},{"name":"KP.4.2.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.4.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T21737A","T29164C"],"S":["F59I"]},"labels":{"aa":"S: F59I","spike_mutations":"F59I"}}},{"name":"internal_7da46150","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.4.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C13862T"],"nsp12":["T141I"]},"labels":{"aa":"nsp12: T141I"}},"children":[{"name":"KP.4.2.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.4.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C3874T","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.4.2.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.4.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.4.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1820A","A6944G","G21665C"],"S":["G35R"],"nsp2":["G339S"],"nsp3":["I1409V"]},"labels":{"aa":"S: G35R; nsp2: G339S; nsp3: I1409V","spike_mutations":"G35R"}}}]}]}]}]},{"name":"NODE_0000961","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{"nuc":["A24819G"],"S":["K1086R"]},"labels":{"aa":"S: K1086R","spike_mutations":"K1086R"}},"children":[{"name":"KP.1","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-02-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.679376602172852}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.20671999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5128878466365139"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["C5884T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_8577b386","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.1.1","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.064725399017334}},"branch_attrs":{"mutations":{}}},{"name":"KP.1.1.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2152C","C25046T"],"S":["P1162S"]},"labels":{"aa":"S: P1162S","spike_mutations":"P1162S"}}},{"name":"KP.1.1.4","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C4540T","C11866T","G22203A"],"S":["R214H"]},"labels":{"aa":"S: R214H","spike_mutations":"R214H"}}},{"name":"internal_ca64dc99","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{"nuc":["C20104T","A22108C"],"S":["K182N"],"nsp15":["L162F"]},"labels":{"aa":"S: K182N; nsp15: L162F","spike_mutations":"K182N"}},"children":[{"name":"KP.1.1.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.018688201904297}},"branch_attrs":{"mutations":{}}},{"name":"MG.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G9536A","C23277T","G23599C"],"S":["T572I","K679N"],"nsp4":["V328I"]},"labels":{"aa":"S: T572I, K679N; nsp4: V328I","spike_mutations":"T572I, K679N"}}}]},{"name":"internal_9b47c581","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.1.1.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.784817218780518}},"branch_attrs":{"mutations":{}}},{"name":"MU.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.5.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C2488T","C13280A","C19172T","C23277T"],"S":["T572I"],"nsp10":["P86T"],"nsp14":["T378I"]},"labels":{"aa":"S: T572I; nsp10: P86T; nsp14: T378I","spike_mutations":"T572I"}}}]},{"name":"internal_0609de9a","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{"nuc":["C4999T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.1.1.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.923412322998047}},"branch_attrs":{"mutations":{}}},{"name":"LP.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C20594T","C21774A"],"S":["S71Y"],"nsp15":["T325I"]},"labels":{"aa":"S: S71Y; nsp15: T325I","spike_mutations":"S71Y"}}},{"name":"LP.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C14293A","A22106G"],"S":["K182E"],"nsp12":["R285S"]},"labels":{"aa":"S: K182E; nsp12: R285S","spike_mutations":"K182E"}}},{"name":"LP.4","node_attrs":{"div":139,"Nextclade_pango":{"value":"LP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G12160A","C23277T","C28087T","C29762T"],"ORF8":["A65V"],"S":["T572I"]},"labels":{"aa":"ORF8: A65V; S: T572I","spike_mutations":"T572I"}}},{"name":"internal_bfd296bd","node_attrs":{"div":136,"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{"nuc":["G25249T"],"S":["M1229I"]},"labels":{"aa":"S: M1229I","spike_mutations":"M1229I"}},"children":[{"name":"LP.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"LP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.200918197631836}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000967","node_attrs":{"div":137,"Nextclade_pango":{"value":"LP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.299785614013672}},"branch_attrs":{"mutations":{"nuc":["T14508C"]}},"children":[{"name":"LP.1.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"LP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.901845455169678}},"branch_attrs":{"mutations":{"nuc":["C22326T"],"S":["S255F"]},"labels":{"aa":"S: S255F","spike_mutations":"S255F"}}},{"name":"LP.1.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"LP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.1.1.3.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["T18300A","G22132T"],"S":["R190S"]},"labels":{"aa":"S: R190S","spike_mutations":"R190S"}}}]}]}]}]}]},{"name":"internal_55cfa969","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"KP.2","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.8013370037078857}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.616637706756592}},"branch_attrs":{"mutations":{"nuc":["C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"KP.2.11","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.11"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6543T","T19377C","T21728G"],"S":["L56V"],"nsp3":["T1275I"]},"labels":{"aa":"S: L56V; nsp3: T1275I","spike_mutations":"L56V"}}},{"name":"KP.2.10","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.10"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.455721855163574}},"branch_attrs":{"mutations":{"nuc":["T21738C"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}}},{"name":"KP.2.14","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.14"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C21627A","C21654T","G22113T"],"S":["T22N","S31F","G184V"]},"labels":{"aa":"S: T22N, S31F, G184V","spike_mutations":"T22N, S31F, G184V"}}},{"name":"KP.2.12","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.12"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["G860A","C4234T","C6040T","A11782G","G25088T","C29230T"],"S":["V1176F"],"nsp2":["E19K"]},"labels":{"aa":"S: V1176F; nsp2: E19K","spike_mutations":"V1176F"}}},{"name":"KP.2.19","node_attrs":{"div":140,"Nextclade_pango":{"value":"KP.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":1.562},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.19"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G347A","C832T","C5833T","C13432T","T14700C","T21653-","C21654-","T21655-","C22792T","T22835C"],"S":["S31-"],"nsp1":["V28I"]},"labels":{"aa":"S: S31-; nsp1: V28I","spike_mutations":"S31-"}}},{"name":"KP.2.23","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.23"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3505T","T9499G","C11020T","T21653-","C21654-","T21655-","C24358A","G25720T","G28122A"],"ORF3a":["A110S"],"ORF8":["G77S"],"S":["S31-"]},"labels":{"aa":"ORF3a: A110S; ORF8: G77S; S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.24","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.24"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.083320617675781}},"branch_attrs":{"mutations":{"nuc":["C9286T","C14919T","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}}},{"name":"KP.2.8","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.8"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A18479T","T21740C","T25039C"],"S":["S60P"],"nsp14":["K147I"]},"labels":{"aa":"S: S60P; nsp14: K147I","spike_mutations":"S60P"}}},{"name":"KP.2.9","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.9"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C15579T","C19512T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"internal_18ef2ccb","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{"nuc":["A10861G","T21653-","C21654-","T21655-"],"S":["S31-"]},"labels":{"aa":"S: S31-","spike_mutations":"S31-"}},"children":[{"name":"KP.2.15","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.675713539123535}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.15.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.15.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A3580G","T9418C","T12304C","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}}]},{"name":"internal_9a8e3486","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{"nuc":["A2512G","G14773A"],"nsp12":["D445N"]},"labels":{"aa":"nsp12: D445N"}},"children":[{"name":"KP.2.20","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-7.7641096115112305}},"branch_attrs":{"mutations":{}}},{"name":"KP.2.20.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.20.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.20.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.096656799316406}},"branch_attrs":{"mutations":{"nuc":["C23277T","A25359G"],"S":["T572I","K1266R"]},"labels":{"aa":"S: T572I, K1266R","spike_mutations":"T572I, K1266R"}}}]},{"name":"internal_53692388","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{"nuc":["T21653-","C21654-","T21655-","C22000A","G25593T"],"ORF3a":["K67N"],"S":["S31-","H146Q"]},"labels":{"aa":"ORF3a: K67N; S: S31-, H146Q","spike_mutations":"S31-, H146Q"}},"children":[{"name":"KP.2.3","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-04-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.022196292877197}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000972","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.286193370819092}},"branch_attrs":{"mutations":{"nuc":["C28714T"]}},"children":[{"name":"KP.2.3.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.40119000000000016"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7908990401504723"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C22986T"],"S":["A475V"]},"labels":{"aa":"S: A475V","spike_mutations":"A475V"}}},{"name":"KP.2.3.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.93998384475708}},"branch_attrs":{"mutations":{"nuc":["G22113T"],"S":["G184V"]},"labels":{"aa":"S: G184V","spike_mutations":"G184V"}}},{"name":"KP.2.3.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A1087G","A23166C"],"S":["K535T"]},"labels":{"aa":"S: K535T","spike_mutations":"K535T"}}},{"name":"KP.2.3.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.3"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["G8A","A22116C","G28166A"],"S":["N185T"]},"labels":{"aa":"S: N185T","spike_mutations":"N185T"}}},{"name":"KP.2.3.6","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.632704734802246}},"branch_attrs":{"mutations":{"nuc":["C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"KP.2.3.4","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3312699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A15759G","A22896C","C27804T"],"S":["H445P"]},"labels":{"aa":"S: H445P","spike_mutations":"H445P"}}},{"name":"NODE_0000973","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{"nuc":["A6626G"],"nsp3":["T1303A"]},"labels":{"aa":"nsp3: T1303A"}},"children":[{"name":"KP.2.3.7","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.2.3.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.114818096160889}},"branch_attrs":{"mutations":{}}},{"name":"MW.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":96},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.3.7.1"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A2618G","A22278G","C27247A"],"ORF6":["L16I"],"S":["Q239R"],"nsp2":["I605V"]},"labels":{"aa":"ORF6: L16I; S: Q239R; nsp2: I605V","spike_mutations":"Q239R"}}}]}]}]},{"name":"NODE_0000974","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.916172504425049}},"branch_attrs":{"mutations":{"nuc":["T22795G"]}},"children":[{"name":"KP.2.13","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.21942999999999988"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7334333297137097"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.13"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5869T","C9565T","A22994G","C24553T","C28289A"],"N":["P6T"],"ORF9b":["D2E"],"S":["K478E"]},"labels":{"aa":"N: P6T; ORF9b: D2E; S: K478E","spike_mutations":"K478E"}}},{"name":"KP.2.17","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.2.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.17"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C7765T","T14418C","G21665C","C23758T"],"S":["G35R"]},"labels":{"aa":"S: G35R","spike_mutations":"G35R"}}},{"name":"KP.2.16","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.16"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.532754898071289}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}}},{"name":"KP.2.18","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.18"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.196435928344727}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"KP.2.2","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.2"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-3.532334089279175}},"branch_attrs":{"mutations":{"nuc":["T21737C","A25359G"],"S":["F59L","K1266R"]},"labels":{"aa":"S: F59L, K1266R","spike_mutations":"F59L, K1266R"}}},{"name":"KP.2.22","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.22"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C4780T","G11417T","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp6":["V149F"]},"labels":{"aa":"S: S31-; nsp6: V149F","spike_mutations":"S31-"}}},{"name":"KP.2.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.4"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-6.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C22311A"],"S":["T250N"]},"labels":{"aa":"S: T250N","spike_mutations":"T250N"}}},{"name":"KP.2.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.5"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.321987628936768}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}}},{"name":"KP.2.6","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.6"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-4.883235931396484}},"branch_attrs":{"mutations":{"nuc":["T21655-","T21656-","T21657-","T21752A"],"S":["F32-","W64R"]},"labels":{"aa":"S: F32-, W64R","spike_mutations":"F32-, W64R"}}},{"name":"KP.2.7","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3181399999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7057624932604036"},"clade_display":{"value":"24B (JN.1.11.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.2.7"},"clade_nextstrain":{"value":"24B"},"clade_membership":{"value":"24B"},"placement_prior":{"value":-5.206736087799072}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}}]}]},{"name":"NODE_0000975","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{"nuc":["C23039G"],"S":["Q493E"]},"labels":{"aa":"S: Q493E","clade":"24C","spike_mutations":"Q493E"}},"children":[{"name":"KP.3","node_attrs":{"div":133,"Nextclade_pango":{"value":"KP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-03-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.987194538116455}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.5","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.331674575805664}},"branch_attrs":{"mutations":{"nuc":["C1420T","G22200A"],"S":["G213E"]},"labels":{"aa":"S: G213E","spike_mutations":"G213E"}}},{"name":"KP.3.6","node_attrs":{"div":134,"Nextclade_pango":{"value":"KP.3.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.7699689865112305}},"branch_attrs":{"mutations":{"nuc":["C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}},{"name":"internal_123a0013","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{"nuc":["C25521T","C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}},"children":[{"name":"KP.3.4.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"KP.3.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["A5G","G3839A","A12199G","C21654T","C28674T","G29449T"],"N":["A134V"],"S":["S31F"],"nsp3":["E374K"]},"labels":{"aa":"N: A134V; S: S31F; nsp3: E374K","spike_mutations":"S31F"}}},{"name":"KP.3.4","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.094726085662842}},"branch_attrs":{"mutations":{}}}]},{"name":"internal_d64a18d7","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{"nuc":["C25006T","C28291A","G28884C"],"N":["R204P"],"ORF9b":["P3H"]},"labels":{"aa":"N: R204P; ORF9b: P3H"}},"children":[{"name":"KP.3.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.5519752502441406}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.3.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"KP.3.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G15543T","C23202A","T25652C","C25803T"],"ORF3a":["F87S"],"S":["T547K"]},"labels":{"aa":"ORF3a: F87S; S: T547K","spike_mutations":"T547K"}}},{"name":"KP.3.3.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5554650921238282"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.030644416809082}},"branch_attrs":{"mutations":{"nuc":["A12666C","G22865T"],"S":["A435S"],"nsp8":["N192T"]},"labels":{"aa":"S: A435S; nsp8: N192T","spike_mutations":"A435S"}}},{"name":"NODE_0000978","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A4364C","T8263C"],"nsp3":["I549L"]},"labels":{"aa":"nsp3: I549L"}},"children":[{"name":"KP.3.3.4","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{}}},{"name":"MR.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G3971A","T21653-","C21654-","T21655-","C25416T"],"S":["S31-"],"nsp3":["V418I"]},"labels":{"aa":"S: S31-; nsp3: V418I","spike_mutations":"S31-"}}}]},{"name":"internal_8cc615e1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.3.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{"nuc":["G9424T"]}},"children":[{"name":"KP.3.3.3","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.125620365142822}},"branch_attrs":{"mutations":{}}},{"name":"ML.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"ML.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["G23604A"],"S":["R681H"]},"labels":{"aa":"S: R681H","spike_mutations":"R681H"}}},{"name":"ML.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"ML.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.3.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G23593T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}}]}]},{"name":"internal_9eb4c558","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{"nuc":["A2611C","C22858T"]}},"children":[{"name":"KP.3.2","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.991495370864868}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.2.1","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.4867472648620605}},"branch_attrs":{"mutations":{"nuc":["C22350T"],"S":["A263V"]},"labels":{"aa":"S: A263V","spike_mutations":"A263V"}}},{"name":"KP.3.2.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C1549T","T22334C"],"S":["W258R"]},"labels":{"aa":"S: W258R","spike_mutations":"W258R"}}},{"name":"KP.3.2.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.0938944816589355}},"branch_attrs":{"mutations":{"nuc":["C25609T"],"ORF3a":["L73F"]},"labels":{"aa":"ORF3a: L73F"}}},{"name":"KP.3.2.5","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.350050449371338}},"branch_attrs":{"mutations":{"nuc":["C1093T","G21746T"],"S":["V62F"]},"labels":{"aa":"S: V62F","spike_mutations":"V62F"}}},{"name":"internal_f3994b77","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{"nuc":["A1T","T2G","C11518T","T25510C"],"ORF3a":["S40P"]},"labels":{"aa":"ORF3a: S40P"}},"children":[{"name":"KP.3.2.3","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.11986780166626}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000982","node_attrs":{"div":140,"Nextclade_pango":{"value":"LW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"LW.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"LW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{}}},{"name":"LW.1.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"LW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":94},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C8639T","C21660T"],"S":["T33I"],"nsp4":["P29S"]},"labels":{"aa":"S: T33I; nsp4: P29S","spike_mutations":"T33I"}}},{"name":"LW.1.2","node_attrs":{"div":142,"Nextclade_pango":{"value":"LW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.2.3.1.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C17373A","C21627A"],"S":["T22N"]},"labels":{"aa":"S: T22N","spike_mutations":"T22N"}}}]}]}]},{"name":"NODE_0000983","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{"nuc":["G15372T","A19722G"]}},"children":[{"name":"KP.3.1","node_attrs":{"div":135,"Nextclade_pango":{"value":"KP.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-3.607269287109375}},"branch_attrs":{"mutations":{}}},{"name":"KP.3.1.3","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.77883243560791}},"branch_attrs":{"mutations":{"nuc":["C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"KP.3.1.7","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.7"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C21216T","C21812A","C29416A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}}},{"name":"KP.3.1.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.5"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G3259T","C23230A","A25948G"],"ORF3a":["I186V"],"S":["N556K"],"nsp3":["Q180H"]},"labels":{"aa":"ORF3a: I186V; S: N556K; nsp3: Q180H","spike_mutations":"N556K"}}},{"name":"NODE_0000984","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{"nuc":["A9235G","T21738C","G29781T"],"S":["F59S"]},"labels":{"aa":"S: F59S","spike_mutations":"F59S"}},"children":[{"name":"KP.3.1.8","node_attrs":{"div":138,"Nextclade_pango":{"value":"KP.3.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.379316329956055}},"branch_attrs":{"mutations":{}}},{"name":"MY.1","node_attrs":{"div":141,"Nextclade_pango":{"value":"MY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.174},"designation_date":{"value":"2024-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.8.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1498T","C22082T","C25583T"],"ORF3a":["T64I"],"S":["P174S"]},"labels":{"aa":"ORF3a: T64I; S: P174S","spike_mutations":"P174S"}}}]},{"name":"internal_8a863937","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{"nuc":["C18490T"],"nsp14":["P151S"]},"labels":{"aa":"nsp14: P151S"}},"children":[{"name":"KP.3.1.4","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.074682235717773}},"branch_attrs":{"mutations":{}}},{"name":"MM.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["T23600C","C29870A"],"S":["S680P"]},"labels":{"aa":"S: S680P","spike_mutations":"S680P"}}},{"name":"MM.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"MM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.4.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G21665C","A22115G","C29572T"],"S":["G35R","N185D"]},"labels":{"aa":"S: G35R, N185D","spike_mutations":"G35R, N185D"}}}]},{"name":"NODE_0000986","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{"nuc":["T19305C"]}},"children":[{"name":"KP.3.1.6","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":90},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.65825891494751}},"branch_attrs":{"mutations":{}}},{"name":"MK.1","node_attrs":{"div":138,"Nextclade_pango":{"value":"MK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T2G","C21654T"],"S":["S31F"]},"labels":{"aa":"S: S31F","spike_mutations":"S31F"}}},{"name":"MK.2","node_attrs":{"div":137,"Nextclade_pango":{"value":"MK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-07-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["A23796G"],"S":["D745G"]},"labels":{"aa":"S: D745G","spike_mutations":"D745G"}}},{"name":"MK.3","node_attrs":{"div":143,"Nextclade_pango":{"value":"MK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.11924"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":95},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.694},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.7206397516519647"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.6.3"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1142T","A4079G","C6471A","A7432G","G8039T","G22599C","A22896G"],"S":["R346T","H445R"],"nsp2":["L113F"],"nsp3":["S454G","T1251N","D1774Y"]},"labels":{"aa":"S: R346T, H445R; nsp2: L113F; nsp3: S454G, T1251N, D1774Y","spike_mutations":"R346T, H445R"}}}]},{"name":"internal_2af12c5b","node_attrs":{"div":136,"Nextclade_pango":{"value":"KP.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-4.946323871612549}},"branch_attrs":{"mutations":{"nuc":["C12616T"]}},"children":[{"name":"KP.3.1.2","node_attrs":{"div":139,"Nextclade_pango":{"value":"KP.3.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24C (KP.3)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.2"},"clade_nextstrain":{"value":"24C"},"clade_membership":{"value":"24C"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C6651T","G22014T","C27143T"],"S":["S151I"],"nsp3":["A1311V"]},"labels":{"aa":"S: S151I; nsp3: A1311V","spike_mutations":"S151I"}}},{"name":"NODE_0000988","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{"nuc":["A13121T","T21653-","C21654-","T21655-"],"S":["S31-"],"nsp10":["S33C"]},"labels":{"aa":"S: S31-; nsp10: S33C","clade":"24E","spike_mutations":"S31-"}},"children":[{"name":"KP.3.1.1","node_attrs":{"div":137,"Nextclade_pango":{"value":"KP.3.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-05-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.2025513648986816}},"branch_attrs":{"mutations":{}}},{"name":"MC.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-06-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.3270463943481445}},"branch_attrs":{"mutations":{"nuc":["C13297T","C23277T"],"S":["T572I"]},"labels":{"aa":"S: T572I","spike_mutations":"T572I"}}},{"name":"MC.10","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.10"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.481916904449463}},"branch_attrs":{"mutations":{"nuc":["C16332T"]}}},{"name":"MC.12","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.12"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.85702657699585}},"branch_attrs":{"mutations":{"nuc":["G21777A"],"S":["G72E"]},"labels":{"aa":"S: G72E","spike_mutations":"G72E"}}},{"name":"MC.15","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.15"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.057847023010254}},"branch_attrs":{"mutations":{"nuc":["A22107G"],"S":["K182R"]},"labels":{"aa":"S: K182R","spike_mutations":"K182R"}}},{"name":"MC.16","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.16"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-3.910944700241089}},"branch_attrs":{"mutations":{"nuc":["G2890A"]}}},{"name":"MC.14","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.14"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.02898645401001}},"branch_attrs":{"mutations":{"nuc":["C22338G"],"S":["T259R"]},"labels":{"aa":"S: T259R","spike_mutations":"T259R"}}},{"name":"MC.3","node_attrs":{"div":142,"Nextclade_pango":{"value":"MC.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.3"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A4T","C9778T","G17679T","G21776A","T28516C"],"ORF9b":["M78T"],"S":["G72R"]},"labels":{"aa":"ORF9b: M78T; S: G72R","spike_mutations":"G72R"}}},{"name":"MC.5","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.5"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.776975631713867}},"branch_attrs":{"mutations":{"nuc":["G25217T"],"S":["G1219C"]},"labels":{"aa":"S: G1219C","spike_mutations":"G1219C"}}},{"name":"MC.6","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.6"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.3801984786987305}},"branch_attrs":{"mutations":{"nuc":["C2570T","G6536A"],"nsp2":["P589S"],"nsp3":["G1273S"]},"labels":{"aa":"nsp2: P589S; nsp3: G1273S"}}},{"name":"MC.7","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.3172000000000001"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5369762101413171"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.7"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-6.544749736785889}},"branch_attrs":{"mutations":{"nuc":["A7330T","C22752T"],"S":["A397V"]},"labels":{"aa":"S: A397V","spike_mutations":"A397V"}}},{"name":"MC.4","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.4"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.832197189331055}},"branch_attrs":{"mutations":{"nuc":["C21855T"],"S":["S98F"]},"labels":{"aa":"S: S98F","spike_mutations":"S98F"}}},{"name":"MC.9","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.9"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.347929000854492}},"branch_attrs":{"mutations":{"nuc":["G17122T","G25617T"],"ORF3a":["K75N"],"nsp13":["A296S"]},"labels":{"aa":"ORF3a: K75N; nsp13: A296S"}}},{"name":"NODE_0000989","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{"nuc":["C17430T"]}},"children":[{"name":"MC.11","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.556859970092773}},"branch_attrs":{"mutations":{}}},{"name":"MC.11.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MC.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.11.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C22329T","C22858T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}}]},{"name":"NODE_0000990","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{"nuc":["C10681T"]}},"children":[{"name":"MC.13","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.422042369842529}},"branch_attrs":{"mutations":{}}},{"name":"MC.13.1","node_attrs":{"div":140,"Nextclade_pango":{"value":"MC.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.13.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C18388T","C22323T"],"S":["S254F"]},"labels":{"aa":"S: S254F","spike_mutations":"S254F"}}}]},{"name":"internal_2e96d2f0","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{"nuc":["G24095T"],"S":["A845S"]},"labels":{"aa":"S: A845S","spike_mutations":"A845S"}},"children":[{"name":"MC.2","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":92},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-4.557940483093262}},"branch_attrs":{"mutations":{}}},{"name":"MC.2.1","node_attrs":{"div":139,"Nextclade_pango":{"value":"MC.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.2.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.050478935241699}},"branch_attrs":{"mutations":{"nuc":["G22272A"],"S":["R237K"]},"labels":{"aa":"S: R237K","spike_mutations":"R237K"}}}]},{"name":"internal_836f2465","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{"nuc":["C9803T"]}},"children":[{"name":"MC.8","node_attrs":{"div":138,"Nextclade_pango":{"value":"MC.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":91},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.253787994384766}},"branch_attrs":{"mutations":{}}},{"name":"MC.8.1","node_attrs":{"div":142,"Nextclade_pango":{"value":"MC.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-1.15353"},"designation_recency":{"value":"4-8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":93},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2024-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.5260901910056954"},"clade_display":{"value":"24E (KP.3.1.1)"},"partiallyAliased":{"value":"BA.2.86.1.1.11.1.3.1.1.8.1"},"clade_nextstrain":{"value":"24E"},"clade_membership":{"value":"24E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T17982C","C18486T","C23277T","G28396A"],"ORF9b":["G38D"],"S":["T572I"]},"labels":{"aa":"ORF9b: G38D; S: T572I","spike_mutations":"T572I"}}}]}]}]}]}]}]}]}]}]}]}]}]},{"name":"BA.45_internal","node_attrs":{"div":74,"Nextclade_pango":{"value":"B.1.1.529"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"21L (BA.2)"},"partiallyAliased":{"value":"B.1.1.529"},"clade_nextstrain":{"value":"21L"},"clade_membership":{"value":"21L"},"placement_prior":{"value":-3.7695722579956055}},"branch_attrs":{"mutations":{"nuc":["G12160A","T21765-","A21766-","C21767-","A21768-","T21769-","G21770-","T22917G","T23018G","G23040A"],"S":["H69-","V70-","L452R","F486V","R493Q"]},"labels":{"aa":"S: H69-, V70-, L452R, F486V, R493Q","spike_mutations":"H69-, V70-, L452R, F486V, R493Q"}},"children":[{"name":"NODE_0000994","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.526405334472656}},"branch_attrs":{"mutations":{"nuc":["C28724T"],"N":["P151S"]},"labels":{"aa":"N: P151S","clade":"22A"}},"children":[{"name":"BA.4.8","node_attrs":{"div":75,"Nextclade_pango":{"value":"BA.4.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.8"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.526405334472656}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0000995","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{"nuc":["A686-","A687-","G688-","T689-","C690-","A691-","T692-","T693-","T694-","G27788T"],"ORF7b":["L11F"],"nsp1":["K141-","S142-","F143-"]},"labels":{"aa":"ORF7b: L11F; nsp1: K141-, S142-, F143-"}},"children":[{"name":"BA.4","node_attrs":{"div":76,"Nextclade_pango":{"value":"BA.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.3252029418945312}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.2","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.538707971572876}},"branch_attrs":{"mutations":{"nuc":["C5173A","T13078C"],"nsp3":["H818Q"]},"labels":{"aa":"nsp3: H818Q"}}},{"name":"NODE_0000996","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.9144246578216553}},"branch_attrs":{"mutations":{"nuc":["A23535G"],"S":["N658S"]},"labels":{"aa":"S: N658S","spike_mutations":"N658S"}},"children":[{"name":"BA.4.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.222130537033081}},"branch_attrs":{"mutations":{"nuc":["C25708T"],"ORF3a":["L106F"]},"labels":{"aa":"ORF3a: L106F"}}},{"name":"BA.4.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.6225922107696533}},"branch_attrs":{"mutations":{"nuc":["C203T","T1453C","C21365T"],"nsp16":["P236L"]},"labels":{"aa":"nsp16: P236L"}}},{"name":"BA.4.5","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.328583717346191}},"branch_attrs":{"mutations":{"nuc":["C1684T","G22104A","A25164T","C29708T"],"S":["G181E","Q1201L"]},"labels":{"aa":"S: G181E, Q1201L","spike_mutations":"G181E, Q1201L"}}},{"name":"BA.4.7","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.7"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.027554035186768}},"branch_attrs":{"mutations":{"nuc":["A10114G","A22600T","A25531G","G26690T"],"ORF3a":["I47V"],"S":["R346S"]},"labels":{"aa":"ORF3a: I47V; S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0000997","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.7857275009155273}},"branch_attrs":{"mutations":{"nuc":["C8140T","C14599T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.6","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.7857275009155273}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.6.1","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.9799063205718994}},"branch_attrs":{"mutations":{"nuc":["G22017T"],"S":["W152L"]},"labels":{"aa":"S: W152L","spike_mutations":"W152L"}}},{"name":"BA.4.6.2","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.516381740570068}},"branch_attrs":{"mutations":{"nuc":["A4233G","G7042T","T22896C"],"S":["V445A"],"nsp3":["D505G","M1441I"]},"labels":{"aa":"S: V445A; nsp3: D505G, M1441I","spike_mutations":"V445A"}}},{"name":"BA.4.6.3","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.71883"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":18},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.482167720794678}},"branch_attrs":{"mutations":{"nuc":["G3152T","T21992-","A21993-","T21994-","G22894C","T22942G"],"S":["Y144-","K444N","N460K"],"nsp3":["G145C"]},"labels":{"aa":"S: Y144-, K444N, N460K; nsp3: G145C","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.4.6.4","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.9110708236694336}},"branch_attrs":{"mutations":{"nuc":["A27579T"],"ORF7a":["Q62H"]},"labels":{"aa":"ORF7a: Q62H"}}},{"name":"NODE_0000998","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{"nuc":["A28390G"],"ORF9b":["N36S"]},"labels":{"aa":"ORF9b: N36S"}},"children":[{"name":"BA.4.6.5","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.6.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8603830337524414}},"branch_attrs":{"mutations":{}}},{"name":"DC.1","node_attrs":{"div":82,"Nextclade_pango":{"value":"DC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66094"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.6.5.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.73586368560791}},"branch_attrs":{"mutations":{"nuc":["A22941G"],"S":["N460S"]},"labels":{"aa":"S: N460S","spike_mutations":"N460S"}}}]}]}]},{"name":"internal_813c","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{"nuc":["T21570G"],"S":["V3G"]},"labels":{"aa":"S: V3G","spike_mutations":"V3G"}},"children":[{"name":"BA.4.1","node_attrs":{"div":77,"Nextclade_pango":{"value":"BA.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-2.6947994232177734}},"branch_attrs":{"mutations":{}}},{"name":"BA.4.1.1","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.7295260429382324}},"branch_attrs":{"mutations":{"nuc":["A23570G"],"S":["I670V"]},"labels":{"aa":"S: I670V","spike_mutations":"I670V"}}},{"name":"BA.4.1.4","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.4"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.100764751434326}},"branch_attrs":{"mutations":{"nuc":["G25266T"],"S":["C1235F"]},"labels":{"aa":"S: C1235F","spike_mutations":"C1235F"}}},{"name":"BA.4.1.3","node_attrs":{"div":80,"Nextclade_pango":{"value":"BA.4.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.3"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.545836448669434}},"branch_attrs":{"mutations":{"nuc":["A2435G","C11758T","C28435T"],"ORF9b":["P51L"],"nsp2":["R544G"]},"labels":{"aa":"ORF9b: P51L; nsp2: R544G"}}},{"name":"BA.4.1.5","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.4.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.5"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.291129112243652}},"branch_attrs":{"mutations":{"nuc":["A3046G","C20762T"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"BA.4.1.6","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.6"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.024025917053223}},"branch_attrs":{"mutations":{"nuc":["C13329T"],"nsp10":["T102I"]},"labels":{"aa":"nsp10: T102I"}}},{"name":"BA.4.1.9","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.9"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.872390031814575}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.4.1.8","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2022-07-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.8"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-3.8587093353271484}},"branch_attrs":{"mutations":{"nuc":["C14322T","T18603C","G22599C","T27786-","T27787-","T27788-","T27789-","G27790-","C27791-","T27792-","T27793-","C28720T"],"ORF7b":["F11-","C12-","F13-"],"S":["R346T"]},"labels":{"aa":"ORF7b: F11-, C12-, F13-; S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001000","node_attrs":{"div":78,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-5.172451496124268}},"branch_attrs":{"mutations":{"nuc":["C14407T"],"nsp12":["L323F"]},"labels":{"aa":"nsp12: L323F"}},"children":[{"name":"BA.4.1.2","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.2"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C3176T","C27644T","C29686T","-29734G","-29735A","-29736G","-29737G","-29738C","-29739C","-29740A","-29741C","-29742G","-29743C","-29744G","-29745G","-29746A","-29747G","-29748T","-29749A","-29750C","-29751G","-29752A","-29753T","-29754C","-29755G","-29756A","-29757G","-29758T","-29759G"],"ORF7a":["P84L"],"nsp3":["P153S"]},"labels":{"aa":"ORF7a: P84L; nsp3: P153S"}}},{"name":"BA.4.1.7","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.4.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.7"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.477802753448486}},"branch_attrs":{"mutations":{"nuc":["A6084G","C17439T","A18941G","A21717G","C26885T"],"S":["Q52R"],"nsp14":["D301G"],"nsp3":["D1122G"]},"labels":{"aa":"S: Q52R; nsp14: D301G; nsp3: D1122G","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001001","node_attrs":{"div":79,"Nextclade_pango":{"value":"BA.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.269092082977295}},"branch_attrs":{"mutations":{"nuc":["G22599C","G29179A"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.4.1.11","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.4.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.11"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C10615T","T15978C","A22001G","T22896C","C27389T","C27476T","A27946T"],"ORF7a":["T28I"],"ORF8":["Q18L"],"S":["K147E","V445A"]},"labels":{"aa":"ORF7a: T28I; ORF8: Q18L; S: K147E, V445A","spike_mutations":"K147E, V445A"}}},{"name":"NODE_0001002","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{"nuc":["A22622G","G25538T"],"ORF3a":["G49V"],"S":["N354D"]},"labels":{"aa":"ORF3a: G49V; S: N354D","spike_mutations":"N354D"}},"children":[{"name":"BA.4.1.10","node_attrs":{"div":81,"Nextclade_pango":{"value":"BA.4.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.67074"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5308081831240151"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-4.778832912445068}},"branch_attrs":{"mutations":{}}},{"name":"CS.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"CS.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5702799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7561969850799493"},"clade_display":{"value":"22A (BA.4)"},"partiallyAliased":{"value":"BA.4.1.10.1"},"clade_nextstrain":{"value":"22A"},"clade_membership":{"value":"22A"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C6070T","G17259C","A22893G","C29784T","C29837T"],"S":["K444R"],"nsp13":["E341D"]},"labels":{"aa":"S: K444R; nsp13: E341D","spike_mutations":"K444R"}}}]}]}]}]}]},{"name":"NODE_0001003","node_attrs":{"div":82,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.162142753601074}},"branch_attrs":{"mutations":{"nuc":["G26529A","T26858C","C27259A","C27382G","T27383A","C27384T","C27889T","G29868A"],"M":["D3N"],"ORF6":["L61D"]},"labels":{"aa":"M: D3N; ORF6: L61D","clade":"22B"}},"children":[{"name":"BA.5","node_attrs":{"div":82,"Nextclade_pango":{"value":"BA.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-04-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.162142753601074}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.9","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39901000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2395057678222656}},"branch_attrs":{"mutations":{"nuc":["T1570C","C11514T","C11674T","C17676T","C18804T","G22599T"],"S":["R346I"],"nsp6":["T181I"]},"labels":{"aa":"S: R346I; nsp6: T181I","spike_mutations":"R346I"}}},{"name":"NODE_0001004","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9982612133026123}},"branch_attrs":{"mutations":{"nuc":["A6551C","G29032A"],"nsp3":["M1278L"]},"labels":{"aa":"nsp3: M1278L"}},"children":[{"name":"BA.5.7","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["G536A","C1314T","C11653T","G14400T","C27532G"],"ORF7a":["H47D"],"nsp1":["E91K"],"nsp2":["T170I"]},"labels":{"aa":"ORF7a: H47D; nsp1: E91K; nsp2: T170I"}}},{"name":"BA.5.8","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.390021324157715}},"branch_attrs":{"mutations":{"nuc":["G17278T","C20594T","C25047T"],"S":["P1162L"],"nsp13":["V348L"],"nsp15":["T325I"]},"labels":{"aa":"S: P1162L; nsp13: V348L; nsp15: T325I","spike_mutations":"P1162L"}}}]},{"name":"NODE_0001005","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9458131790161133}},"branch_attrs":{"mutations":{"nuc":["C21789T"],"S":["T76I"]},"labels":{"aa":"S: T76I","spike_mutations":"T76I"}},"children":[{"name":"BA.5.5.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.243049144744873}},"branch_attrs":{"mutations":{"nuc":["C4540T","G15452T","C24766T"],"nsp12":["G671V"]},"labels":{"aa":"nsp12: G671V"}}},{"name":"BA.5.5","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9458131790161133}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001006","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.89169979095459}},"branch_attrs":{"mutations":{"nuc":["C5512T"]}},"children":[{"name":"BA.5.5.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5131309032440186}},"branch_attrs":{"mutations":{"nuc":["A22910G","G28077T"],"ORF8":["V62L"],"S":["N450D"]},"labels":{"aa":"ORF8: V62L; S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.5.3","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.18776798248291}},"branch_attrs":{"mutations":{"nuc":["T4388C","G9761T","T14408G"],"nsp12":["L323R"],"nsp4":["V403F"]},"labels":{"aa":"nsp12: L323R; nsp4: V403F"}}}]}]},{"name":"NODE_0001007","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0763678550720215}},"branch_attrs":{"mutations":{"nuc":["T4906C","C17402T","T18957C","C21077T"],"nsp13":["A389V"],"nsp16":["T140I"]},"labels":{"aa":"nsp13: A389V; nsp16: T140I"}},"children":[{"name":"BA.5.6","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0763678550720215}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001008","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1130268573760986}},"branch_attrs":{"mutations":{"nuc":["G18984T"],"nsp14":["M315I"]},"labels":{"aa":"nsp14: M315I"}},"children":[{"name":"BA.5.6.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9632551670074463}},"branch_attrs":{"mutations":{"nuc":["T29597C"],"ORF10":["Y14H"]},"labels":{"aa":"ORF10: Y14H"}}},{"name":"BA.5.6.4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.6.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5883099999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T979A","A22598G","G22599A"],"S":["R346E"]},"labels":{"aa":"S: R346E","spike_mutations":"R346E"}}},{"name":"BA.5.6.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.6.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C21697T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001009","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{"nuc":["C8605T","A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.6.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.6.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.320345878601074}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001010","node_attrs":{"div":91,"Nextclade_pango":{"value":"BW.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["G2144A","C14599T","T22942G"],"S":["N460K"],"nsp2":["V447I"]},"labels":{"aa":"S: N460K; nsp2: V447I","spike_mutations":"N460K"}},"children":[{"name":"BW.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6570799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A4916G","T21992-","A21993-","T21994-","A22600T"],"S":["Y144-","R346S"],"nsp3":["I733V"]},"labels":{"aa":"S: Y144-, R346S; nsp3: I733V","spike_mutations":"Y144-, R346S"}}},{"name":"NODE_0001011","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23019C","G29044A"],"S":["Y144-","V486A"]},"labels":{"aa":"S: Y144-, V486A","spike_mutations":"Y144-, V486A"}},"children":[{"name":"BW.1.1.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BW.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C16468T"],"nsp13":["P78S"]},"labels":{"aa":"nsp13: P78S"}}},{"name":"BW.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BW.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.300266265869141}},"branch_attrs":{"mutations":{}}},{"name":"BW.1.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BW.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77355"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.6.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.391443252563477}},"branch_attrs":{"mutations":{"nuc":["C2855T","C23557T"],"nsp3":["L46F"]},"labels":{"aa":"nsp3: L46F"}}}]}]}]}]},{"name":"NODE_0001012","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.2667036056518555}},"branch_attrs":{"mutations":{"nuc":["A1T","T27438C","C29666T"],"ORF10":["L37F"]},"labels":{"aa":"ORF10: L37F"}},"children":[{"name":"BA.5.1","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":50},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.2667036056518555}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.1.12","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4272186756134033}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BA.5.1.14","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.96599817276001}},"branch_attrs":{"mutations":{"nuc":["G7452T"],"nsp3":["S1578I"]},"labels":{"aa":"nsp3: S1578I"}}},{"name":"BA.5.1.16","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.954094409942627}},"branch_attrs":{"mutations":{"nuc":["A2969G","G27470A"],"ORF7a":["G26D"],"nsp3":["M84V"]},"labels":{"aa":"ORF7a: G26D; nsp3: M84V"}}},{"name":"BA.5.1.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["T6376C","T7368C","A12030G","G28904T","T29867A"],"N":["A211S"],"nsp3":["I1550T"],"nsp7":["Q63R"]},"labels":{"aa":"N: A211S; nsp3: I1550T; nsp7: Q63R"}}},{"name":"BA.5.1.2","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2638373374938965}},"branch_attrs":{"mutations":{"nuc":["G27214A"],"ORF6":["V5I"]},"labels":{"aa":"ORF6: V5I"}}},{"name":"BA.5.1.17","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7746376991271973}},"branch_attrs":{"mutations":{"nuc":["C25517T"],"ORF3a":["P42L"]},"labels":{"aa":"ORF3a: P42L"}}},{"name":"BA.5.1.24","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3640358448028564}},"branch_attrs":{"mutations":{"nuc":["G17278T"],"nsp13":["V348L"]},"labels":{"aa":"nsp13: V348L"}}},{"name":"BA.5.1.28","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257040023803711}},"branch_attrs":{"mutations":{"nuc":["A18480G","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.1.3","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1503190994262695}},"branch_attrs":{"mutations":{"nuc":["G22427A"],"S":["V289I"]},"labels":{"aa":"S: V289I","spike_mutations":"V289I"}}},{"name":"BA.5.1.30","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.9021759033203125}},"branch_attrs":{"mutations":{"nuc":["C16323T","A27218G"],"ORF6":["D6G"]},"labels":{"aa":"ORF6: D6G"}}},{"name":"BA.5.1.34","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":20},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.065857410430908}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","C2142T","C11530T","C15720T","A22001-","A22002-","A22003-","A22004-","A22005-","C22006-","C25046T"],"S":["K147-","N148-","P1162S"],"nsp1":["G82-","H83-","V84-","M85-"],"nsp2":["P446L"]},"labels":{"aa":"S: K147-, N148-, P1162S; nsp1: G82-, H83-, V84-, M85-; nsp2: P446L","spike_mutations":"K147-, N148-, P1162S"}}},{"name":"BA.5.1.4","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G3614A","C4794G","G16700T","C18303A"],"nsp13":["R155L"],"nsp3":["V299I","S692C"]},"labels":{"aa":"nsp13: R155L; nsp3: V299I, S692C"}}},{"name":"BA.5.1.7","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.88628888130188}},"branch_attrs":{"mutations":{"nuc":["C44T","C15026T","C16293T","C20462T"],"nsp12":["A529V"],"nsp15":["T281I"]},"labels":{"aa":"nsp12: A529V; nsp15: T281I"}}},{"name":"BA.5.1.8","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6331071853637695}},"branch_attrs":{"mutations":{"nuc":["C10798T","C12747T","C21110T"],"nsp16":["T151I"],"nsp9":["T21I"]},"labels":{"aa":"nsp16: T151I; nsp9: T21I"}}},{"name":"BA.5.1.5","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1470396518707275}},"branch_attrs":{"mutations":{"nuc":["C16428T","C25350A"],"S":["P1263Q"]},"labels":{"aa":"S: P1263Q","spike_mutations":"P1263Q"}}},{"name":"BA.5.1.6","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.541717767715454}},"branch_attrs":{"mutations":{"nuc":["G4622A","T5653C"],"nsp3":["V635I"]},"labels":{"aa":"nsp3: V635I"}}},{"name":"NODE_0001013","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{"nuc":["A11781G","C28462T"],"ORF9b":["T60I"],"nsp6":["K270R"]},"labels":{"aa":"ORF9b: T60I; nsp6: K270R"}},"children":[{"name":"BA.5.1.10","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3361661434173584}},"branch_attrs":{"mutations":{}}},{"name":"BK.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"BK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9346795082092285}},"branch_attrs":{"mutations":{"nuc":["G1820A"],"nsp2":["G339S"]},"labels":{"aa":"nsp2: G339S"}}}]},{"name":"internal_6f22","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{"nuc":["C10790T"],"nsp5":["H246Y"]},"labels":{"aa":"nsp5: H246Y"}},"children":[{"name":"BA.5.1.15","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.097557067871094}},"branch_attrs":{"mutations":{}}},{"name":"DL.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"DL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.15.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.854553461074829}},"branch_attrs":{"mutations":{"nuc":["C8140T","C19029T","G22894T","T22942G","G23593T"],"S":["K444N","N460K","Q677H"]},"labels":{"aa":"S: K444N, N460K, Q677H","spike_mutations":"K444N, N460K, Q677H"}}}]},{"name":"NODE_0001015","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.22"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{"nuc":["C17285T"],"nsp13":["S350L"]},"labels":{"aa":"nsp13: S350L"}},"children":[{"name":"BA.5.1.22","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2130861282348633}},"branch_attrs":{"mutations":{}}},{"name":"DH.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"DH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.22.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C6543T","G6860A","A8456G","A21993-","T21994-","T21995-","A21996-","C21997-","C21998-"],"S":["Y145-","H146-"],"nsp3":["T1275I","A1381T","S1913G"]},"labels":{"aa":"S: Y145-, H146-; nsp3: T1275I, A1381T, S1913G","spike_mutations":"Y145-, H146-"}}}]},{"name":"NODE_0001016","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{"nuc":["G22599C","A25594G","C26681T"],"ORF3a":["R68G"],"S":["R346T"]},"labels":{"aa":"ORF3a: R68G; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.26","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460143566131592}},"branch_attrs":{"mutations":{}}},{"name":"CU.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"CU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.26.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C21846T","C23202A"],"S":["T95I","T547K"]},"labels":{"aa":"S: T95I, T547K","spike_mutations":"T95I, T547K"}}}]},{"name":"internal_35cd","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3032753467559814}},"branch_attrs":{"mutations":{"nuc":["G25855T"],"ORF3a":["D155Y"]},"labels":{"aa":"ORF3a: D155Y"}},"children":[{"name":"BA.5.1.31","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.787606716156006}},"branch_attrs":{"mutations":{"nuc":["A5317G","C5339T","C6310T","C12853T","G16975A","C26636T","C28435T"],"ORF9b":["P51L"],"nsp13":["V247I"],"nsp3":["P874S"]},"labels":{"aa":"ORF9b: P51L; nsp13: V247I; nsp3: P874S"}}},{"name":"BA.5.1.38","node_attrs":{"div":95,"Nextclade_pango":{"value":"BA.5.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["A13611G","G21232A","G21255T","G22599C","C24700T","C28201T","C28531T","C29518T","T29867A"],"ORF8":["S103L"],"ORF9b":["T83I"],"S":["R346T"],"nsp16":["A192T"]},"labels":{"aa":"ORF8: S103L; ORF9b: T83I; S: R346T; nsp16: A192T","spike_mutations":"R346T"}}}]},{"name":"internal_8226","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.35"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{"nuc":["A4840G"],"nsp3":["I707M"]},"labels":{"aa":"nsp3: I707M"}},"children":[{"name":"BA.5.1.35","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.198977947235107}},"branch_attrs":{"mutations":{}}},{"name":"EB.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"EB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.35.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.850436687469482}},"branch_attrs":{"mutations":{"nuc":["A9409G","A13623G","G22599C","C28531T"],"ORF9b":["T83I"],"S":["R346T"]},"labels":{"aa":"ORF9b: T83I; S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001019","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.33"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{"nuc":["A4595G","G15451A","G25352T","C28567T"],"ORF9b":["T95M"],"S":["V1264L"],"nsp12":["G671S"],"nsp3":["T626A"]},"labels":{"aa":"ORF9b: T95M; S: V1264L; nsp12: G671S; nsp3: T626A","spike_mutations":"V1264L"}},"children":[{"name":"BA.5.1.33","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416933536529541}},"branch_attrs":{"mutations":{}}},{"name":"EQ.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"EQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.33.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}}]},{"name":"internal_bae4","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8467981815338135}},"branch_attrs":{"mutations":{"nuc":["C1170T"],"nsp2":["S122F"]},"labels":{"aa":"nsp2: S122F"}},"children":[{"name":"BA.5.1.23","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8467981815338135}},"branch_attrs":{"mutations":{}}},{"name":"internal_4e3e","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.23"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.115823268890381}},"branch_attrs":{"mutations":{"nuc":["T27696C"]}},"children":[{"name":"DE.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G2267A","G2494A","T4579A","G12211A","T15326C","C22000T","G22104T","G22599C","C25792T"],"ORF3a":["R134C"],"S":["G181V","R346T"],"nsp12":["M629T"],"nsp2":["A488T"]},"labels":{"aa":"ORF3a: R134C; S: G181V, R346T; nsp12: M629T; nsp2: A488T","spike_mutations":"G181V, R346T"}}},{"name":"DE.1","node_attrs":{"div":88,"Nextclade_pango":{"value":"DE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.23.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.336248397827148}},"branch_attrs":{"mutations":{"nuc":["C23643T"],"S":["A694V"]},"labels":{"aa":"S: A694V","spike_mutations":"A694V"}}}]}]},{"name":"NODE_0001022","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4300601482391357}},"branch_attrs":{"mutations":{"nuc":["C10507T","G19174A"],"nsp14":["D379N"]},"labels":{"aa":"nsp14: D379N"}},"children":[{"name":"BA.5.1.18","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7965614795684814}},"branch_attrs":{"mutations":{"nuc":["C1514T","C10279T","C14396T","G17893T","G22599C","T27482A"],"ORF7a":["L30H"],"S":["R346T"],"nsp12":["T319I"],"nsp13":["A553S"],"nsp2":["H237Y"]},"labels":{"aa":"ORF7a: L30H; S: R346T; nsp12: T319I; nsp13: A553S; nsp2: H237Y","spike_mutations":"R346T"}}},{"name":"NODE_0001023","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.069719314575195}},"branch_attrs":{"mutations":{"nuc":["G15451A","C29284T"],"nsp12":["G671S"]},"labels":{"aa":"nsp12: G671S"}},"children":[{"name":"BA.5.1.21","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.069719314575195}},"branch_attrs":{"mutations":{}}},{"name":"BT.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["C27494A"],"ORF7a":["P34H"]},"labels":{"aa":"ORF7a: P34H"}}},{"name":"BT.2","node_attrs":{"div":90,"Nextclade_pango":{"value":"BT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.21.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["A28288G"],"ORF9b":["D2G"]},"labels":{"aa":"ORF9b: D2G"}}}]}]},{"name":"internal_b005","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5216658115386963}},"branch_attrs":{"mutations":{"nuc":["A16541G"],"nsp13":["N102S"]},"labels":{"aa":"nsp13: N102S"}},"children":[{"name":"BA.5.1.27","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7831978797912598}},"branch_attrs":{"mutations":{"nuc":["A12949G","G22599C","A28254-"],"ORF8":["I121-"],"S":["R346T"]},"labels":{"aa":"ORF8: I121-; S: R346T","spike_mutations":"R346T"}}},{"name":"internal_1b4f","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.29"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{"nuc":["G22894T","G28925T"],"N":["A218S"],"S":["K444N"]},"labels":{"aa":"N: A218S; S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.1.29","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-6.641659736633301}},"branch_attrs":{"mutations":{}}},{"name":"internal_f0e8","node_attrs":{"div":92,"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{"nuc":["C9226T","A22010G","T22942A","T28015G"],"ORF8":["F41C"],"S":["K150E","N460K"]},"labels":{"aa":"ORF8: F41C; S: K150E, N460K","spike_mutations":"K150E, N460K"}},"children":[{"name":"CL.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C10894T","C13968T","C25047T"],"S":["P1162L"]},"labels":{"aa":"S: P1162L","spike_mutations":"P1162L"}}},{"name":"CL.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CL.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160994052886963}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001027","node_attrs":{"div":94,"Nextclade_pango":{"value":"CL.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.229829788208008}},"branch_attrs":{"mutations":{"nuc":["T17319C","C22120T"]}},"children":[{"name":"CL.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"CL.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CL.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.29.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.569317817687988}},"branch_attrs":{"mutations":{"nuc":["C21774T"],"S":["S71F"]},"labels":{"aa":"S: S71F","spike_mutations":"S71F"}}}]}]}]}]},{"name":"internal_2d50","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8071255683898926}},"branch_attrs":{"mutations":{"nuc":["C11494T","C27879T"],"ORF7b":["H42Y"]},"labels":{"aa":"ORF7b: H42Y"}},"children":[{"name":"BA.5.1.25","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8071255683898926}},"branch_attrs":{"mutations":{}}},{"name":"internal_eec6","node_attrs":{"div":89,"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.107795715332031}},"branch_attrs":{"mutations":{"nuc":["T2C","G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"DJ.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"DJ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.107795715332031}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001030","node_attrs":{"div":90,"Nextclade_pango":{"value":"DJ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.246993541717529}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"DJ.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"DJ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T9070C","C10125T","A18556G","A22924G"],"nsp14":["T173A"],"nsp5":["T24I"]},"labels":{"aa":"nsp14: T173A; nsp5: T24I"}}},{"name":"DJ.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DJ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C4234T","G8872T","A12644G","C14599T","C22088T","G28287A"],"N":["G5E"],"ORF9b":["D2N"],"S":["L176F"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp4":["L106F"],"nsp8":["I185V"]},"labels":{"aa":"N: G5E; ORF9b: D2N; S: L176F; nsp1: G82-, H83-, V84-, M85-, V86-; nsp4: L106F; nsp8: I185V","spike_mutations":"L176F"}}},{"name":"NODE_0001031","node_attrs":{"div":92,"Nextclade_pango":{"value":"DJ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{"nuc":["C21757T","A29066T"],"N":["T265S"]},"labels":{"aa":"N: T265S"}},"children":[{"name":"DJ.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"DJ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.424724102020264}},"branch_attrs":{"mutations":{}}},{"name":"DJ.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"DJ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.25.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C2T","C920T","G12661A","T15516C","C18747T","A22003T","G28027C"],"ORF8":["W45S"],"S":["K147N"]},"labels":{"aa":"ORF8: W45S; S: K147N","spike_mutations":"K147N"}}}]}]}]}]},{"name":"NODE_0001032","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7332913875579834}},"branch_attrs":{"mutations":{"nuc":["C29614T"]}},"children":[{"name":"BA.5.1.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0832855701446533}},"branch_attrs":{"mutations":{"nuc":["C25672A"],"ORF3a":["L94I"]},"labels":{"aa":"ORF3a: L94I"}}},{"name":"BA.5.1.19","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0474534034729}},"branch_attrs":{"mutations":{"nuc":["G15451T"],"nsp12":["G671C"]},"labels":{"aa":"nsp12: G671C"}}},{"name":"BA.5.1.32","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C10615T","C14265T","C17130T","C17746T","G18160A","C23191T","G28509T","G29090T"],"N":["S79I","A273S"],"ORF9b":["V76F"],"nsp13":["P504S"],"nsp14":["D41N"]},"labels":{"aa":"N: S79I, A273S; ORF9b: V76F; nsp13: P504S; nsp14: D41N"}}},{"name":"BA.5.1.9","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.180713653564453}},"branch_attrs":{"mutations":{"nuc":["C5221T","A14827G","A27218G","G29864-","A29865-","A29866-","T29867-","A29868-"],"ORF6":["D6G"],"nsp12":["M463V"]},"labels":{"aa":"ORF6: D6G; nsp12: M463V"}}},{"name":"NODE_0001033","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.130020618438721}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.1.20","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.533609390258789}},"branch_attrs":{"mutations":{"nuc":["A4485T"],"nsp3":["K589M"]},"labels":{"aa":"nsp3: K589M"}}},{"name":"BA.5.1.36","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T2884C","T11940C","T13983C","G22344T","G28325T"],"N":["G18C"],"ORF9b":["L14F"],"S":["G261V"],"nsp7":["V33A"]},"labels":{"aa":"N: G18C; ORF9b: L14F; S: G261V; nsp7: V33A","spike_mutations":"G261V"}}},{"name":"BA.5.1.37","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.1.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.071262359619141}},"branch_attrs":{"mutations":{"nuc":["G17721T","T22304A"],"S":["Y248N"]},"labels":{"aa":"S: Y248N","spike_mutations":"Y248N"}}}]}]}]},{"name":"NODE_0001034","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.150343418121338}},"branch_attrs":{"mutations":{"nuc":["C1627T"]}},"children":[{"name":"BA.5.11","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":22},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7931668758392334}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","G22599C","C27389T","T27523C","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","A27677G"],"ORF7a":["S44P","E92-","V93-","Q94-","E95G"],"S":["R346T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: S44P, E92-, V93-, Q94-, E95G; S: R346T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"R346T"}}},{"name":"internal_6f02","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{"nuc":["C884T","A12030G","G22346T","A26392G","G29422T"],"E":["S50G"],"S":["A262S"],"nsp2":["R27C"],"nsp7":["Q63R"]},"labels":{"aa":"E: S50G; S: A262S; nsp2: R27C; nsp7: Q63R","spike_mutations":"A262S"}},"children":[{"name":"BA.5.10","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.301711082458496}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001036","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{"nuc":["C44T","C9803T","C20762T","G22599C"],"S":["R346T"],"nsp16":["T35I"]},"labels":{"aa":"S: R346T; nsp16: T35I","spike_mutations":"R346T"}},"children":[{"name":"BA.5.10.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.27914571762085}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001037","node_attrs":{"div":94,"Nextclade_pango":{"value":"DF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{"nuc":["A3858G","T13794C","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp3":["Q380R"]},"labels":{"aa":"S: Y144-; nsp3: Q380R","spike_mutations":"Y144-"}},"children":[{"name":"DF.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"DF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.50931978225708}},"branch_attrs":{"mutations":{}}},{"name":"DF.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.10.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["C15738T","T22896C","C28045T"],"ORF8":["A51V"],"S":["V445A"]},"labels":{"aa":"ORF8: A51V; S: V445A","spike_mutations":"V445A"}}}]}]}]},{"name":"BA52_BA510_internal","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7062840461730957}},"branch_attrs":{"mutations":{"nuc":["A1G","A28330G"],"ORF9b":["D16G"]},"labels":{"aa":"ORF9b: D16G"}},"children":[{"name":"BA.5.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7062840461730957}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001039","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6787030696868896}},"branch_attrs":{"mutations":{"nuc":["A27038G"]}},"children":[{"name":"BA.5.2.1","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6787030696868896}},"branch_attrs":{"mutations":{}}},{"name":"BF.12","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5279"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.953214645385742}},"branch_attrs":{"mutations":{"nuc":["G23018A"],"S":["V486I"]},"labels":{"aa":"S: V486I","spike_mutations":"V486I"}}},{"name":"BF.14","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.078192710876465}},"branch_attrs":{"mutations":{"nuc":["C16726T","A22910G"],"S":["N450D"],"nsp13":["H164Y"]},"labels":{"aa":"S: N450D; nsp13: H164Y","spike_mutations":"N450D"}}},{"name":"BF.19","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C9223T","C19017T","G22200A","C28695T"],"N":["T141I"],"S":["G213E"]},"labels":{"aa":"N: T141I; S: G213E","spike_mutations":"G213E"}}},{"name":"BF.18","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.091021537780762}},"branch_attrs":{"mutations":{"nuc":["G25489T"],"ORF3a":["A33S"]},"labels":{"aa":"ORF3a: A33S"}}},{"name":"BF.17","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.485513687133789}},"branch_attrs":{"mutations":{"nuc":["T1570C","G8903A"],"nsp4":["D117N"]},"labels":{"aa":"nsp4: D117N"}}},{"name":"BF.33","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6034899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C10834T","A15812G","C20762T","G22599T","T22942G"],"S":["R346I","N460K"],"nsp12":["N791S"],"nsp16":["T35I"]},"labels":{"aa":"S: R346I, N460K; nsp12: N791S; nsp16: T35I","spike_mutations":"R346I, N460K"}}},{"name":"BF.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.552757501602173}},"branch_attrs":{"mutations":{"nuc":["A22337G"],"S":["T259A"]},"labels":{"aa":"S: T259A","spike_mutations":"T259A"}}},{"name":"BF.6","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.914626359939575}},"branch_attrs":{"mutations":{"nuc":["C18084T","G22104C"],"S":["G181A"]},"labels":{"aa":"S: G181A","spike_mutations":"G181A"}}},{"name":"BF.8","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4885289669036865}},"branch_attrs":{"mutations":{"nuc":["C29358A"],"N":["T362K"]},"labels":{"aa":"N: T362K"}}},{"name":"NODE_0001040","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.624391078948975}},"branch_attrs":{"mutations":{"nuc":["C12789T"],"nsp9":["T35I"]},"labels":{"aa":"nsp9: T35I"}},"children":[{"name":"BF.30","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["C3330T","C7945T","C9559T","C14599T","G22599C","C25916T"],"ORF3a":["T175I"],"S":["R346T"],"nsp3":["T204I"]},"labels":{"aa":"ORF3a: T175I; S: R346T; nsp3: T204I","spike_mutations":"R346T"}}},{"name":"BF.35","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T2454G","C4921T","T6979G","T9727C","G15138T","A22910G","C25452T","C27434T","C29509T"],"ORF7a":["T14I"],"S":["N450D"],"nsp12":["M566I"],"nsp2":["L550R"]},"labels":{"aa":"ORF7a: T14I; S: N450D; nsp12: M566I; nsp2: L550R","spike_mutations":"N450D"}}}]},{"name":"NODE_0001041","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.26798677444458}},"branch_attrs":{"mutations":{"nuc":["C23758T"]}},"children":[{"name":"BF.31","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.26798677444458}},"branch_attrs":{"mutations":{}}},{"name":"BF.31.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.31.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.31.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C14724T","G18651A","G22302-","T22303-","T22304-","C23664T","C28013T","C28744T"],"S":["S247-","Y248N","A701V"]},"labels":{"aa":"S: S247-, Y248N, A701V","spike_mutations":"S247-, Y248N, A701V"}}}]},{"name":"internal_f84b","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.001974582672119}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"BF.39","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.001974582672119}},"branch_attrs":{"mutations":{}}},{"name":"BF.39.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.39.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.33263"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5959379308450252"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.39.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.379688739776611}},"branch_attrs":{"mutations":{"nuc":["T2290C","C11833T","G16700T","T22896C","A22910G","C29675T"],"S":["V445A","N450D"],"nsp13":["R155L"]},"labels":{"aa":"S: V445A, N450D; nsp13: R155L","spike_mutations":"V445A, N450D"}}}]},{"name":"internal_a7a7","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.41"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.132727146148682}},"branch_attrs":{"mutations":{"nuc":["C27883T"],"ORF7b":["A43V"]},"labels":{"aa":"ORF7b: A43V"}},"children":[{"name":"BF.41","node_attrs":{"div":87,"Nextclade_pango":{"value":"BF.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.132727146148682}},"branch_attrs":{"mutations":{}}},{"name":"BF.41.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.41.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.41.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.439579963684082}},"branch_attrs":{"mutations":{"nuc":["C678T","G10943A","G22599C","C23893T"],"S":["R346T"],"nsp1":["A138V"],"nsp5":["V297I"]},"labels":{"aa":"S: R346T; nsp1: A138V; nsp5: V297I","spike_mutations":"R346T"}}}]},{"name":"NODE_0001044","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.576507329940796}},"branch_attrs":{"mutations":{"nuc":["C140T","G22599C","C26151T","T28271C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.11.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C25317T"],"S":["S1252F"]},"labels":{"aa":"S: S1252F","spike_mutations":"S1252F"}}},{"name":"BF.11","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.576507329940796}},"branch_attrs":{"mutations":{}}},{"name":"BF.11.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.11.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A1856G","C6190T","G22225T","T28255A"],"ORF8":["I121N"],"nsp2":["S351G"]},"labels":{"aa":"ORF8: I121N; nsp2: S351G"}}},{"name":"BF.11.4","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.462855339050293}},"branch_attrs":{"mutations":{"nuc":["C23673T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"NODE_0001045","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.166012287139893}},"branch_attrs":{"mutations":{"nuc":["C27389T"]}},"children":[{"name":"BF.11.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.11.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.181137561798096}},"branch_attrs":{"mutations":{"nuc":["T3541C","A6467C","C14877T","G21255C","A22003C","C27998T"],"S":["K147N"],"nsp3":["T1250P"]},"labels":{"aa":"S: K147N; nsp3: T1250P","spike_mutations":"K147N"}}},{"name":"BF.11.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.11.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.11.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.292903900146484}},"branch_attrs":{"mutations":{"nuc":["C629T"],"nsp1":["L122F"]},"labels":{"aa":"nsp1: L122F"}}}]}]},{"name":"NODE_0001046","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7686774730682373}},"branch_attrs":{"mutations":{"nuc":["T6979G"]}},"children":[{"name":"BF.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7894070148468018}},"branch_attrs":{"mutations":{"nuc":["G14398T"],"nsp12":["V320L"]},"labels":{"aa":"nsp12: V320L"}}},{"name":"BF.28","node_attrs":{"div":88,"Nextclade_pango":{"value":"BF.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2664027214050293}},"branch_attrs":{"mutations":{"nuc":["A396T"],"nsp1":["Q44L"]},"labels":{"aa":"nsp1: Q44L"}}},{"name":"BF.36","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8735766410827637}},"branch_attrs":{"mutations":{"nuc":["A761G","C17285T","C17750T"],"nsp1":["S166G"],"nsp13":["S350L","A505V"]},"labels":{"aa":"nsp1: S166G; nsp13: S350L, A505V"}}},{"name":"BF.9","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.462024211883545}},"branch_attrs":{"mutations":{"nuc":["G5555A","G9220A","G11053C","C16859T","C21727T","C28651T"],"nsp13":["A208V"],"nsp3":["G946S"],"nsp6":["Q27H"]},"labels":{"aa":"nsp13: A208V; nsp3: G946S; nsp6: Q27H"}}},{"name":"NODE_0001047","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1384172439575195}},"branch_attrs":{"mutations":{"nuc":["C17339T","C28310T"],"N":["L13F"],"nsp13":["A368V"]},"labels":{"aa":"N: L13F; nsp13: A368V"}},"children":[{"name":"BF.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1384172439575195}},"branch_attrs":{"mutations":{}}},{"name":"BF.10.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.3218"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.563032084337257"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.10.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.989957809448242}},"branch_attrs":{"mutations":{"nuc":["C22591T","T22896C","G22898A","A29824T"],"S":["V445A","G446S"]},"labels":{"aa":"S: V445A, G446S","spike_mutations":"V445A, G446S"}}}]},{"name":"NODE_0001048","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.431779384613037}},"branch_attrs":{"mutations":{"nuc":["T4690C","G21520T","C22879T"],"nsp16":["V288F"]},"labels":{"aa":"nsp16: V288F"}},"children":[{"name":"BF.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.431779384613037}},"branch_attrs":{"mutations":{}}},{"name":"BF.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["G526T","T3038C","A3213G","G10835A","G11837T","C13297T"],"nsp1":["E87D"],"nsp3":["Y107H","D165G"],"nsp5":["V261I"],"nsp6":["V289L"]},"labels":{"aa":"nsp1: E87D; nsp3: Y107H, D165G; nsp5: V261I; nsp6: V289L"}}}]},{"name":"NODE_0001049","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1216320991516113}},"branch_attrs":{"mutations":{"nuc":["C26625T","C27371T"],"ORF6":["P57L"]},"labels":{"aa":"ORF6: P57L"}},"children":[{"name":"BF.15","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.382207870483398}},"branch_attrs":{"mutations":{"nuc":["T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}},{"name":"BF.20","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.540201187133789}},"branch_attrs":{"mutations":{"nuc":["C7086A"],"nsp3":["T1456N"]},"labels":{"aa":"nsp3: T1456N"}}}]},{"name":"NODE_0001050","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.864048957824707}},"branch_attrs":{"mutations":{"nuc":["C28087A"],"ORF8":["A65D"]},"labels":{"aa":"ORF8: A65D"}},"children":[{"name":"BF.21","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1568260192871094}},"branch_attrs":{"mutations":{"nuc":["C936T","C2189T","A3069G","C25916T"],"ORF3a":["T175I"],"nsp2":["T44I","L462F"],"nsp3":["D117G"]},"labels":{"aa":"ORF3a: T175I; nsp2: T44I, L462F; nsp3: D117G"}}},{"name":"BF.27","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3812055587768555}},"branch_attrs":{"mutations":{"nuc":["C8616T","C21114T"],"nsp4":["A21V"]},"labels":{"aa":"nsp4: A21V"}}}]},{"name":"NODE_0001051","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.45866060256958}},"branch_attrs":{"mutations":{"nuc":["A3859G"]}},"children":[{"name":"BF.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.780573606491089}},"branch_attrs":{"mutations":{"nuc":["A8031G","A19337G","A22600T","T24079C","G26196A"],"S":["R346S"],"nsp14":["K433R"],"nsp3":["K1771R"]},"labels":{"aa":"S: R346S; nsp14: K433R; nsp3: K1771R","spike_mutations":"R346S"}}},{"name":"BF.16","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.369936466217041}},"branch_attrs":{"mutations":{"nuc":["T11177C","A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BF.22","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["A9343G","T23269C","C28419T","C29409T"],"N":["T49I","T379I"]},"labels":{"aa":"N: T49I, T379I"}}},{"name":"BF.25","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.527681350708008}},"branch_attrs":{"mutations":{"nuc":["C18657T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.29","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.740543842315674}},"branch_attrs":{"mutations":{"nuc":["T26171A","G26172A"],"ORF3a":["M260K"]},"labels":{"aa":"ORF3a: M260K"}}},{"name":"BF.34","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.168172359466553}},"branch_attrs":{"mutations":{"nuc":["C21516T","G22599C","G23499A","G25737T"],"ORF3a":["L115F"],"S":["R346T","R646H"]},"labels":{"aa":"ORF3a: L115F; S: R346T, R646H","spike_mutations":"R346T, R646H"}}}]},{"name":"NODE_0001052","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.68562650680542}},"branch_attrs":{"mutations":{"nuc":["G24620T"],"S":["A1020S"]},"labels":{"aa":"S: A1020S","spike_mutations":"A1020S"}},"children":[{"name":"BF.23","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.741713047027588}},"branch_attrs":{"mutations":{"nuc":["C4784T","C17076A"],"nsp3":["L689F"]},"labels":{"aa":"nsp3: L689F"}}},{"name":"internal_faef","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}},"children":[{"name":"BF.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.32490348815918}},"branch_attrs":{"mutations":{}}},{"name":"BF.3.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.48889999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2785964012146}},"branch_attrs":{"mutations":{"nuc":["G22898A","C27549T"],"S":["G446S"]},"labels":{"aa":"S: G446S","spike_mutations":"G446S"}}}]},{"name":"internal_3b8c","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.661747455596924}},"branch_attrs":{"mutations":{"nuc":["C9967T"]}},"children":[{"name":"BF.24","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.670074462890625}},"branch_attrs":{"mutations":{"nuc":["G2177T"],"nsp2":["G458C"]},"labels":{"aa":"nsp2: G458C"}}},{"name":"NODE_0001055","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160424709320068}},"branch_attrs":{"mutations":{"nuc":["C19524T","C27532T"],"ORF7a":["H47Y"]},"labels":{"aa":"ORF7a: H47Y"}},"children":[{"name":"BF.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.160424709320068}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001056","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.755507469177246}},"branch_attrs":{"mutations":{"nuc":["A28402G"],"ORF9b":["K40R"]},"labels":{"aa":"ORF9b: K40R"}},"children":[{"name":"BF.5.5","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.5.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.592724323272705}},"branch_attrs":{"mutations":{"nuc":["A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"NODE_0001057","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.0702502727508545}},"branch_attrs":{"mutations":{"nuc":["A8882G"],"nsp4":["I110V"]},"labels":{"aa":"nsp4: I110V"}},"children":[{"name":"BF.5.1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.266281604766846}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"NODE_0001058","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.605588436126709}},"branch_attrs":{"mutations":{"nuc":["C16954T"]}},"children":[{"name":"BF.5.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.5.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.848393201828003}},"branch_attrs":{"mutations":{"nuc":["A11781G"],"nsp6":["K270R"]},"labels":{"aa":"nsp6: K270R"}}},{"name":"NODE_0001059","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.972652435302734}},"branch_attrs":{"mutations":{"nuc":["C29077T"]}},"children":[{"name":"BF.5.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"BF.5.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C44T","C11668T","T22896C","T23443C","C27393T"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BF.5.3","node_attrs":{"div":114,"Nextclade_pango":{"value":"BF.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-08"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T1965C","T2158C","G3719A","A7863G","C9442T","T11045C","C12915T","G16360A","A20463G","A20472G","C21178T","G21372A","T22090C","T22711C","C23170T","C24964T","C25702T","A28877T","G28878C"],"ORF3a":["P104S"],"nsp13":["V42I"],"nsp16":["H174Y"],"nsp2":["I387T"],"nsp3":["G334S","K1715R"],"nsp9":["T77I"]},"labels":{"aa":"ORF3a: P104S; nsp13: V42I; nsp16: H174Y; nsp2: I387T; nsp3: G334S, K1715R; nsp9: T77I"}}}]}]}]}]}]}]}]}]},{"name":"internal_cd9e","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.604036331176758}},"branch_attrs":{"mutations":{"nuc":["G28361T","G28371T"],"N":["G30-","-33F"],"ORF9b":["M26-","-29I","V30L"]},"labels":{"aa":"N: G30-, -33F; ORF9b: M26-, -29I, V30L"}},"children":[{"name":"BF.42","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7b:14-44"},"designation_date":{"value":"2023-04-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.42"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C1059T","C1968T","C8025T","C12068T","A12820G","C16608T","C17747T","C21054T","A21137G","T27792-","A28008G"],"ORF7b":["F13-"],"ORF8":["I39V"],"nsp13":["P504L"],"nsp16":["K160R"],"nsp2":["T85I","T388I"],"nsp3":["A1769V"]},"labels":{"aa":"ORF7b: F13-; ORF8: I39V; nsp13: P504L; nsp16: K160R; nsp2: T85I, T388I; nsp3: A1769V"}}},{"name":"internal_928a","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.397202253341675}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BF.26","node_attrs":{"div":90,"Nextclade_pango":{"value":"BF.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.212219476699829}},"branch_attrs":{"mutations":{"nuc":["G14593A"],"nsp12":["G385S"]},"labels":{"aa":"nsp12: G385S"}}},{"name":"BF.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257172107696533}},"branch_attrs":{"mutations":{"nuc":["C4920A","G15451A","A22910G"],"S":["N450D"],"nsp12":["G671S"],"nsp3":["T734N"]},"labels":{"aa":"S: N450D; nsp12: G671S; nsp3: T734N","spike_mutations":"N450D"}}},{"name":"BF.37","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.416947364807129}},"branch_attrs":{"mutations":{"nuc":["C3096T","T7855C","G22899A"],"S":["G446D"],"nsp3":["S126L"]},"labels":{"aa":"S: G446D; nsp3: S126L","spike_mutations":"G446D"}}},{"name":"BF.40","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.40"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.287536382675171}},"branch_attrs":{"mutations":{"nuc":["G3838A","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}}]},{"name":"internal_1cd3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.238622665405273}},"branch_attrs":{"mutations":{"nuc":["C17304T"]}},"children":[{"name":"BF.38","node_attrs":{"div":89,"Nextclade_pango":{"value":"BF.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.238622665405273}},"branch_attrs":{"mutations":{}}},{"name":"BF.38.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.38.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["C15277T","T22896C"],"S":["V445A"],"nsp12":["H613Y"]},"labels":{"aa":"S: V445A; nsp12: H613Y","spike_mutations":"V445A"}}},{"name":"BF.38.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.38.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["T1582C","C6395T","T11122C","C25046T","C25416T","C28087T","A28254-"],"ORF8":["A65V","I121-"],"S":["P1162S"]},"labels":{"aa":"ORF8: A65V, I121-; S: P1162S","spike_mutations":"P1162S"}}},{"name":"BF.38.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.38.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.38.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.086867809295654}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}}]},{"name":"NODE_0001063","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{"nuc":["G1T","C7528T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BF.7","node_attrs":{"div":91,"Nextclade_pango":{"value":"BF.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.840324878692627}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.541253089904785}},"branch_attrs":{"mutations":{"nuc":["C44T","C25162A","C25163A"],"S":["Q1201K"]},"labels":{"aa":"S: Q1201K","spike_mutations":"Q1201K"}}},{"name":"BF.7.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1160783767700195}},"branch_attrs":{"mutations":{"nuc":["G22344T"],"S":["G261V"]},"labels":{"aa":"S: G261V","spike_mutations":"G261V"}}},{"name":"BF.7.12","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.685693264007568}},"branch_attrs":{"mutations":{"nuc":["G24386T"],"S":["A942S"]},"labels":{"aa":"S: A942S","spike_mutations":"A942S"}}},{"name":"BF.7.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C2842T","A14475G","G25340T"],"S":["D1260Y"]},"labels":{"aa":"S: D1260Y","spike_mutations":"D1260Y"}}},{"name":"BF.7.18","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.512073040008545}},"branch_attrs":{"mutations":{"nuc":["C44T","G21853T"],"S":["K97N"]},"labels":{"aa":"S: K97N","spike_mutations":"K97N"}}},{"name":"BF.7.17","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.17"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C4719T","A16687G","C23625T","G25061A"],"S":["A688V","G1167S"],"nsp13":["I151V"],"nsp3":["A667V"]},"labels":{"aa":"S: A688V, G1167S; nsp13: I151V; nsp3: A667V","spike_mutations":"A688V, G1167S"}}},{"name":"BF.7.15","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.15"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.538332223892212}},"branch_attrs":{"mutations":{"nuc":["C5700T","G22332A"],"S":["G257D"],"nsp3":["A994V"]},"labels":{"aa":"S: G257D; nsp3: A994V","spike_mutations":"G257D"}}},{"name":"BF.7.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6393200000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.51876163482666}},"branch_attrs":{"mutations":{"nuc":["G23018A","C24863T","C25919T"],"ORF3a":["T176I"],"S":["V486I","H1101Y"]},"labels":{"aa":"ORF3a: T176I; S: V486I, H1101Y","spike_mutations":"V486I, H1101Y"}}},{"name":"BF.7.20","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7448062896728516}},"branch_attrs":{"mutations":{"nuc":["G15543T"]}}},{"name":"BF.7.22","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9261090755462646}},"branch_attrs":{"mutations":{"nuc":["T9107C","T27794C","G28134A"],"ORF8":["V81I"]},"labels":{"aa":"ORF8: V81I"}}},{"name":"BF.7.21","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.868741989135742}},"branch_attrs":{"mutations":{"nuc":["A6058G","C28603T"]}}},{"name":"BF.7.23","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.092196941375732}},"branch_attrs":{"mutations":{"nuc":["C14183T"],"nsp12":["T248I"]},"labels":{"aa":"nsp12: T248I"}}},{"name":"BF.7.26","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.052380561828613}},"branch_attrs":{"mutations":{"nuc":["G20679A"]}}},{"name":"BF.7.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.385432720184326}},"branch_attrs":{"mutations":{"nuc":["C44T","C15951T","A22106G","C29870A"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}},{"name":"BF.7.24","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.015725612640381}},"branch_attrs":{"mutations":{"nuc":["T10939C"]}}},{"name":"BF.7.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7265236377716064}},"branch_attrs":{"mutations":{"nuc":["A2692T","C15540T","G26109T"],"ORF3a":["E239D"]},"labels":{"aa":"ORF3a: E239D"}}},{"name":"BF.7.7","node_attrs":{"div":95,"Nextclade_pango":{"value":"BF.7.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.219905853271484}},"branch_attrs":{"mutations":{"nuc":["A11506G","C20436T","A21801G","A29868G"],"S":["D80G"]},"labels":{"aa":"S: D80G","spike_mutations":"D80G"}}},{"name":"BF.7.8","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.259110450744629}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BF.7.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["T22615C","G23593T","C26681T"],"S":["Q677H"]},"labels":{"aa":"S: Q677H","spike_mutations":"Q677H"}}},{"name":"NODE_0001064","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{"nuc":["C1758T","T2080C"],"nsp2":["A318V"]},"labels":{"aa":"nsp2: A318V"}},"children":[{"name":"BF.7.16","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.778438091278076}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.16.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.16.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.16.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.062829494476318}},"branch_attrs":{"mutations":{"nuc":["C6633T","C22792T","C23625T"],"S":["A688V"],"nsp3":["A1305V"]},"labels":{"aa":"S: A688V; nsp3: A1305V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001065","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.19"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{"nuc":["A27747C"],"ORF7a":["R118S"]},"labels":{"aa":"ORF7a: R118S"}},"children":[{"name":"BF.7.19","node_attrs":{"div":92,"Nextclade_pango":{"value":"BF.7.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.246763706207275}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.19.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.19.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.19.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1314496994018555}},"branch_attrs":{"mutations":{"nuc":["C1915T","T7111C","C16470T","A26219G","C28153T"],"ORF8":["T87I"]},"labels":{"aa":"ORF8: T87I"}}}]},{"name":"NODE_0001066","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{"nuc":["A17622G","C17747T","A28777G"],"nsp13":["P504L"]},"labels":{"aa":"nsp13: P504L"}},"children":[{"name":"BF.7.5.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.5.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.257694721221924}},"branch_attrs":{"mutations":{"nuc":["C1288T","C2399A","T21992-","A21993-","T21994-","G22104T","C26985T"],"M":["H155Y"],"S":["Y144-","G181V"],"nsp2":["H532N"]},"labels":{"aa":"M: H155Y; S: Y144-, G181V; nsp2: H532N","spike_mutations":"Y144-, G181V"}}},{"name":"BF.7.5","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7494490146636963}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001067","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{"nuc":["C1427T","C3743T"],"nsp2":["H208Y"],"nsp3":["H342Y"]},"labels":{"aa":"nsp2: H208Y; nsp3: H342Y"}},"children":[{"name":"BF.7.13.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6759999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["T21462C","C22851T","C23603T"],"S":["T430I","H681Y"]},"labels":{"aa":"S: T430I, H681Y","spike_mutations":"T430I, H681Y"}}},{"name":"BF.7.13.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.13.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["A3601G","C23520T","T29760C","T29867A"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BF.7.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.419810771942139}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001068","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{"nuc":["T21483C","C27942T"],"ORF8":["H17Y"]},"labels":{"aa":"ORF8: H17Y"}},"children":[{"name":"BF.7.4.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T1683C","C20703T","C22033A","A26927G","C27532A","G28541T"],"N":["A90S"],"ORF7a":["H47N"],"ORF9b":["E86D"],"S":["F157L"],"nsp2":["I293T"]},"labels":{"aa":"N: A90S; ORF7a: H47N; ORF9b: E86D; S: F157L; nsp2: I293T","spike_mutations":"F157L"}}},{"name":"BF.7.4","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.005715370178223}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001069","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6762619018554688}},"branch_attrs":{"mutations":{"nuc":["T13096C"]}},"children":[{"name":"BF.7.4.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3122618198394775}},"branch_attrs":{"mutations":{"nuc":["C9365T","C17746T","T21180C"],"nsp13":["P504S"]},"labels":{"aa":"nsp13: P504S"}}},{"name":"BF.7.4.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6336T","T18700A","T21763C","C23191T"],"nsp14":["S221T"],"nsp3":["S1206L"]},"labels":{"aa":"nsp14: S221T; nsp3: S1206L"}}}]}]},{"name":"NODE_0001070","node_attrs":{"div":93,"Nextclade_pango":{"value":"BF.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.051523685455322}},"branch_attrs":{"mutations":{"nuc":["G14181C","C27532T"],"ORF7a":["H47Y"],"nsp12":["L247F"]},"labels":{"aa":"ORF7a: H47Y; nsp12: L247F"}},"children":[{"name":"BF.7.27","node_attrs":{"div":94,"Nextclade_pango":{"value":"BF.7.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C8752T"]}}},{"name":"NODE_0001071","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{"nuc":["G1085T","G25290T","C29632T"],"S":["C1243F"],"nsp2":["V94L"]},"labels":{"aa":"S: C1243F; nsp2: V94L","spike_mutations":"C1243F"}},"children":[{"name":"BF.7.14","node_attrs":{"div":96,"Nextclade_pango":{"value":"BF.7.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.0043158531188965}},"branch_attrs":{"mutations":{}}},{"name":"BF.7.14.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4443793296813965}},"branch_attrs":{"mutations":{"nuc":["A3872G","A8967C"],"nsp3":["I385V"],"nsp4":["K138T"]},"labels":{"aa":"nsp3: I385V; nsp4: K138T"}}},{"name":"BF.7.14.4","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.413344860076904}},"branch_attrs":{"mutations":{"nuc":["C5796T","C25701T","A29868G"],"nsp3":["T1026I"]},"labels":{"aa":"nsp3: T1026I"}}},{"name":"BF.7.14.5","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.325514793395996}},"branch_attrs":{"mutations":{"nuc":["C20703T","A29868G"]}}},{"name":"BF.7.14.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C44T","T11587C","C24624T"],"S":["S1021F"]},"labels":{"aa":"S: S1021F","spike_mutations":"S1021F"}}},{"name":"NODE_0001072","node_attrs":{"div":97,"Nextclade_pango":{"value":"BF.7.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.729614734649658}},"branch_attrs":{"mutations":{"nuc":["G210T"]}},"children":[{"name":"BF.7.14.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"BF.7.14.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.155583381652832}},"branch_attrs":{"mutations":{"nuc":["G21604T"],"S":["Q14H"]},"labels":{"aa":"S: Q14H","spike_mutations":"Q14H"}}},{"name":"BF.7.14.3","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","C23439T"],"S":["A626V"]},"labels":{"aa":"S: A626V","spike_mutations":"A626V"}}},{"name":"BF.7.14.6","node_attrs":{"div":99,"Nextclade_pango":{"value":"BF.7.14.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.1.7.14.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C1973T","A29868G"]}}}]}]}]}]}]}]},{"name":"NODE_0001073","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.6321189403533936}},"branch_attrs":{"mutations":{"nuc":["G12310A"]}},"children":[{"name":"BA.5.2.23","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.23"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.815160036087036}},"branch_attrs":{"mutations":{"nuc":["A4576T","T4579A","C22326T","T22896C"],"S":["S255F","V445A"]},"labels":{"aa":"S: S255F, V445A","spike_mutations":"S255F, V445A"}}},{"name":"BA.5.2.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.182589054107666}},"branch_attrs":{"mutations":{"nuc":["C23202T"],"S":["T547I"]},"labels":{"aa":"S: T547I","spike_mutations":"T547I"}}},{"name":"BA.5.2.40","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.40"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G1148T","A17406G","C18252T","G19666T","C21575T","A22910G"],"S":["L5F","N450D"],"nsp15":["D16Y"],"nsp2":["G115C"]},"labels":{"aa":"S: L5F, N450D; nsp15: D16Y; nsp2: G115C","spike_mutations":"L5F, N450D"}}},{"name":"BA.5.2.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.82459020614624}},"branch_attrs":{"mutations":{"nuc":["G3606T","C3903T","C10138T","C11454T","T18429C","T27053C"],"nsp3":["C296F","P395L"],"nsp6":["A161V"]},"labels":{"aa":"nsp3: C296F, P395L; nsp6: A161V"}}},{"name":"BA.5.2.9","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.992318630218506}},"branch_attrs":{"mutations":{"nuc":["C10369T","A15002G"],"nsp12":["Y521C"]},"labels":{"aa":"nsp12: Y521C"}}},{"name":"NODE_0001074","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2580161094665527}},"branch_attrs":{"mutations":{"nuc":["C16616A"],"nsp13":["T127N"]},"labels":{"aa":"nsp13: T127N"}},"children":[{"name":"BA.5.2.10","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.743117332458496}},"branch_attrs":{"mutations":{"nuc":["G3514T","G28646A"],"N":["A125T"],"nsp3":["M265I"]},"labels":{"aa":"N: A125T; nsp3: M265I"}}},{"name":"BA.5.2.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.626256227493286}},"branch_attrs":{"mutations":{"nuc":["G20356A","C29510A"],"N":["R413S"],"nsp15":["G246S"]},"labels":{"aa":"N: R413S; nsp15: G246S"}}},{"name":"NODE_0001075","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.856178045272827}},"branch_attrs":{"mutations":{"nuc":["C25714G"],"ORF3a":["L108V"]},"labels":{"aa":"ORF3a: L108V"}},"children":[{"name":"BA.5.2.26","node_attrs":{"div":88,"Nextclade_pango":{"value":"BA.5.2.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.856178045272827}},"branch_attrs":{"mutations":{}}},{"name":"CG.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.26.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.208289623260498}},"branch_attrs":{"mutations":{"nuc":["C4824T","A22893T","C24133T","C27143T"],"S":["K444M"],"nsp3":["S702F"]},"labels":{"aa":"S: K444M; nsp3: S702F","spike_mutations":"K444M"}}}]},{"name":"NODE_0001076","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.190217971801758}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.22","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.22"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.498509168624878}},"branch_attrs":{"mutations":{"nuc":["C3330T"],"nsp3":["T204I"]},"labels":{"aa":"nsp3: T204I"}}},{"name":"BA.5.2.28","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.28"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2399187088012695}},"branch_attrs":{"mutations":{"nuc":["C4575T"],"nsp3":["T619I"]},"labels":{"aa":"nsp3: T619I"}}},{"name":"BA.5.2.29","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.29"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.531074523925781}},"branch_attrs":{"mutations":{"nuc":["T6218C","C13517T"],"nsp12":["T26I"]},"labels":{"aa":"nsp12: T26I"}}},{"name":"BA.5.2.45","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5131699999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.45"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.998836994171143}},"branch_attrs":{"mutations":{"nuc":["T239C","C21595T","A22892C","C25710T","C27557T"],"ORF7a":["A55V"],"S":["K444Q"]},"labels":{"aa":"ORF7a: A55V; S: K444Q","spike_mutations":"K444Q"}}},{"name":"BA.5.2.52","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.52"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161757469177246}},"branch_attrs":{"mutations":{"nuc":["G6443A","A22910G"],"S":["N450D"],"nsp3":["D1242N"]},"labels":{"aa":"S: N450D; nsp3: D1242N","spike_mutations":"N450D"}}},{"name":"BA.5.2.55","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.55"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.999176263809204}},"branch_attrs":{"mutations":{"nuc":["C5548A"]}}},{"name":"BA.5.2.59","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.59"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.273857593536377}},"branch_attrs":{"mutations":{"nuc":["C10138T","G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"NODE_0001077","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.33"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9824564456939697}},"branch_attrs":{"mutations":{"nuc":["C28170T"],"ORF8":["P93S"]},"labels":{"aa":"ORF8: P93S"}},"children":[{"name":"BA.5.2.33","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9824564456939697}},"branch_attrs":{"mutations":{}}},{"name":"CE.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39901000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.33.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.402862548828125}},"branch_attrs":{"mutations":{"nuc":["G22599T"],"S":["R346I"]},"labels":{"aa":"S: R346I","spike_mutations":"R346I"}}}]},{"name":"NODE_0001078","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.49"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.6803436279296875}},"branch_attrs":{"mutations":{"nuc":["A14673G","T16456C","C24210T","G29810T"],"S":["T883I"],"nsp13":["S74P"]},"labels":{"aa":"S: T883I; nsp13: S74P","spike_mutations":"T883I"}},"children":[{"name":"BA.5.2.49","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.6803436279296875}},"branch_attrs":{"mutations":{}}},{"name":"DZ.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["C44T","C8950T","G21786T"],"S":["G75V"]},"labels":{"aa":"S: G75V","spike_mutations":"G75V"}}},{"name":"DZ.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.49.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.574712753295898}},"branch_attrs":{"mutations":{"nuc":["C8626T","G11266T","T13698C","G24998T"],"S":["D1146Y"],"nsp6":["L98F"]},"labels":{"aa":"S: D1146Y; nsp6: L98F","spike_mutations":"D1146Y"}}}]}]},{"name":"NODE_0001079","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.190217971801758}},"branch_attrs":{"mutations":{"nuc":["C27012T","C27513T"]}},"children":[{"name":"BA.5.2.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.14"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.301711559295654}},"branch_attrs":{"mutations":{"nuc":["C6720T","T16617C","G21753T","A22893T","G29422T"],"S":["W64L","K444M"],"nsp3":["T1334I"]},"labels":{"aa":"S: W64L, K444M; nsp3: T1334I","spike_mutations":"W64L, K444M"}}},{"name":"BA.5.2.12","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.3988966941833496}},"branch_attrs":{"mutations":{"nuc":["C29358T"],"N":["T362I"]},"labels":{"aa":"N: T362I"}}},{"name":"BA.5.2.13","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6936419010162354}},"branch_attrs":{"mutations":{"nuc":["A13136G","C13264T","G22599C"],"S":["R346T"],"nsp10":["I38V"]},"labels":{"aa":"S: R346T; nsp10: I38V","spike_mutations":"R346T"}}},{"name":"BA.5.2.19","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.19"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7941067218780518}},"branch_attrs":{"mutations":{"nuc":["C25433T"],"ORF3a":["T14I"]},"labels":{"aa":"ORF3a: T14I"}}},{"name":"BA.5.2.30","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.30"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.567555904388428}},"branch_attrs":{"mutations":{"nuc":["C8605T","G22899A"],"S":["G446D"]},"labels":{"aa":"S: G446D","spike_mutations":"G446D"}}},{"name":"BA.5.2.34","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.34"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5116841793060303}},"branch_attrs":{"mutations":{"nuc":["G18079T","G22599C","G23587A"],"S":["R346T"],"nsp14":["V14L"]},"labels":{"aa":"S: R346T; nsp14: V14L","spike_mutations":"R346T"}}},{"name":"BA.5.2.35","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.35"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6543288230895996}},"branch_attrs":{"mutations":{"nuc":["C7006T","T16617C","G22599C","G28423C"],"ORF9b":["R47P"],"S":["R346T"]},"labels":{"aa":"ORF9b: R47P; S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.37","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.37"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.460197925567627}},"branch_attrs":{"mutations":{"nuc":["G6943T","T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"BA.5.2.39","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.39"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C44T","C1471T","T2698C","C4543T","T8662C","A12976T","G22599C","A29700G"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BA.5.2.42","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.42"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C1426T","C7011T","C11750T","C17012T","A22893C","T24352C","C24503A","C26873T"],"S":["K444T","L981I"],"nsp13":["S259L"],"nsp3":["A1431V"],"nsp6":["L260F"]},"labels":{"aa":"S: K444T, L981I; nsp13: S259L; nsp3: A1431V; nsp6: L260F","spike_mutations":"K444T, L981I"}}},{"name":"BA.5.2.43","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5642800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5413273873731987"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.43"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9836483001708984}},"branch_attrs":{"mutations":{"nuc":["C5301T","C15933T","G22899A","T22942G"],"S":["G446D","N460K"],"nsp3":["A861V"]},"labels":{"aa":"S: G446D, N460K; nsp3: A861V","spike_mutations":"G446D, N460K"}}},{"name":"BA.5.2.44","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.44"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.282502174377441}},"branch_attrs":{"mutations":{"nuc":["C7955T"],"nsp3":["L1746F"]},"labels":{"aa":"nsp3: L1746F"}}},{"name":"BA.5.2.46","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.46"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.21357536315918}},"branch_attrs":{"mutations":{"nuc":["A1793G","A22893C","T22942G","C26681T","T29867A"],"S":["K444T","N460K"],"nsp2":["K330E"]},"labels":{"aa":"S: K444T, N460K; nsp2: K330E","spike_mutations":"K444T, N460K"}}},{"name":"BA.5.2.53","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.53"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.239440441131592}},"branch_attrs":{"mutations":{"nuc":["T17928C","C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.54","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.54"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.244083881378174}},"branch_attrs":{"mutations":{"nuc":["C11020T","A22910G"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"BA.5.2.57","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.57"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7188966274261475}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.58","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.58"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.236837387084961}},"branch_attrs":{"mutations":{"nuc":["C9565T","C11479T","C12085T","A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"BA.5.2.62","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.62"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.200337886810303}},"branch_attrs":{"mutations":{"nuc":["C23520T"],"S":["A653V"]},"labels":{"aa":"S: A653V","spike_mutations":"A653V"}}},{"name":"BA.5.2.63","node_attrs":{"div":97,"Nextclade_pango":{"value":"BA.5.2.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.63"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G2407A","C2485T","C2592T","C5646T","C8752T","T21992-","A21993-","T21994-","G22894T","T22942A","A27293G","C29733-","-29759T"],"ORF6":["Y31C"],"S":["Y144-","K444N","N460K"],"nsp2":["A596V"],"nsp3":["T976I"]},"labels":{"aa":"ORF6: Y31C; S: Y144-, K444N, N460K; nsp2: A596V; nsp3: T976I","spike_mutations":"Y144-, K444N, N460K"}}},{"name":"BA.5.2.61","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.61"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.71628475189209}},"branch_attrs":{"mutations":{"nuc":["A19676T","A22910G","G29706C"],"S":["N450D"],"nsp15":["Q19L"]},"labels":{"aa":"S: N450D; nsp15: Q19L","spike_mutations":"N450D"}}},{"name":"BA.5.2.8","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.947103977203369}},"branch_attrs":{"mutations":{"nuc":["G8872T","T19305C"],"nsp4":["L106F"]},"labels":{"aa":"nsp4: L106F"}}},{"name":"internal_236a","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3597493171691895}},"branch_attrs":{"mutations":{"nuc":["C27294T"]}},"children":[{"name":"BA.5.2.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.216500759124756}},"branch_attrs":{"mutations":{"nuc":["C15951T","C25693G"],"ORF3a":["L101V"]},"labels":{"aa":"ORF3a: L101V"}}},{"name":"BA.5.2.32","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.32"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.365072250366211}},"branch_attrs":{"mutations":{"nuc":["A22910G","C28153T"],"ORF8":["T87I"],"S":["N450D"]},"labels":{"aa":"ORF8: T87I; S: N450D","spike_mutations":"N450D"}}}]},{"name":"internal_f0ba","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.27"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.812326431274414}},"branch_attrs":{"mutations":{"nuc":["A7259G"],"nsp3":["I1514V"]},"labels":{"aa":"nsp3: I1514V"}},"children":[{"name":"BA.5.2.27","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.812326431274414}},"branch_attrs":{"mutations":{}}},{"name":"CF.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.27.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.800739765167236}},"branch_attrs":{"mutations":{"nuc":["A21852C"],"S":["K97T"]},"labels":{"aa":"S: K97T","spike_mutations":"K97T"}}}]},{"name":"internal_1651","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.36"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.183862686157227}},"branch_attrs":{"mutations":{"nuc":["A22893C"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.36","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.183862686157227}},"branch_attrs":{"mutations":{}}},{"name":"CT.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4564899999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7208595659836455"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.36.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.672360420227051}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A22629C","G29212T"],"S":["Y144-","K356T"]},"labels":{"aa":"S: Y144-, K356T","spike_mutations":"Y144-, K356T"}}}]},{"name":"internal_a10d","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.363097667694092}},"branch_attrs":{"mutations":{"nuc":["C22851T"],"S":["T430I"]},"labels":{"aa":"S: T430I","spike_mutations":"T430I"}},"children":[{"name":"BA.5.2.38","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.56458"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.30660604695253"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.363097667694092}},"branch_attrs":{"mutations":{}}},{"name":"DA.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"DA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6759999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4998596931256571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.38.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.474554061889648}},"branch_attrs":{"mutations":{"nuc":["C478T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}}]},{"name":"NODE_0001084","node_attrs":{"div":89,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{"nuc":["A22893G"]}},"children":[{"name":"BA.5.2.41","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.41"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.726138114929199}},"branch_attrs":{"mutations":{"nuc":["C8655T"],"S":["K444R"],"nsp4":["S34F"]},"labels":{"aa":"S: K444R; nsp4: S34F","spike_mutations":"K444R"}}},{"name":"BA.5.2.56","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.56"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.041224479675293}},"branch_attrs":{"mutations":{"nuc":["G22893T"],"S":["K444M"]},"labels":{"aa":"S: K444M","spike_mutations":"K444M"}}}]},{"name":"internal_ea0e","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.47"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.329527378082275}},"branch_attrs":{"mutations":{"nuc":["C12616T","G22599C","C24745T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.47","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.329527378082275}},"branch_attrs":{"mutations":{}}},{"name":"DQ.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.47.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4955315589904785}},"branch_attrs":{"mutations":{"nuc":["C6781T","T12673G","C19011T","A22003T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}}]},{"name":"NODE_0001086","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.20"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{"nuc":["C23707T"]}},"children":[{"name":"BA.5.2.20","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.1044797897338867}},"branch_attrs":{"mutations":{}}},{"name":"BV.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.852180480957031}},"branch_attrs":{"mutations":{"nuc":["C22314A","G24603A","C27059T"],"S":["P251H","R1014K"]},"labels":{"aa":"S: P251H, R1014K","spike_mutations":"P251H, R1014K"}}},{"name":"BV.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BV.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.20.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.280701637268066}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}}}]},{"name":"NODE_0001087","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.21"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4698431491851807}},"branch_attrs":{"mutations":{"nuc":["C5284T"]}},"children":[{"name":"BA.5.2.21","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-18"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.4698431491851807}},"branch_attrs":{"mutations":{}}},{"name":"CN.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.227382659912109}},"branch_attrs":{"mutations":{"nuc":["A22910G","C25626T"],"S":["N450D"]},"labels":{"aa":"S: N450D","spike_mutations":"N450D"}}},{"name":"CN.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"CN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.21.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.357228755950928}},"branch_attrs":{"mutations":{"nuc":["A17943G","T18345C","T21644C","G22599C"],"S":["Y28H","R346T"]},"labels":{"aa":"S: Y28H, R346T","spike_mutations":"Y28H, R346T"}}}]},{"name":"internal_6217","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{"nuc":["G625T","G2305A"],"nsp1":["K120N"]},"labels":{"aa":"nsp1: K120N"}},"children":[{"name":"BA.5.2.3","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5976035594940186}},"branch_attrs":{"mutations":{}}},{"name":"BZ.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.85455322265625}},"branch_attrs":{"mutations":{"nuc":["G315A","G17331T","G23593C","C28657T"],"S":["Q677H"],"nsp1":["S17N"],"nsp13":["E365D"]},"labels":{"aa":"S: Q677H; nsp1: S17N; nsp13: E365D","spike_mutations":"Q677H"}}},{"name":"BZ.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.3.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.214097023010254}},"branch_attrs":{"mutations":{"nuc":["C8645T","C16887T","A22910G"],"S":["N450D"],"nsp4":["H31Y"]},"labels":{"aa":"S: N450D; nsp4: H31Y","spike_mutations":"N450D"}}}]},{"name":"internal_74ef","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.31"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.185973167419434}},"branch_attrs":{"mutations":{"nuc":["C21812A"],"S":["L84I"]},"labels":{"aa":"S: L84I","spike_mutations":"L84I"}},"children":[{"name":"BA.5.2.31","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.185973167419434}},"branch_attrs":{"mutations":{}}},{"name":"CD.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CD.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5594199999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3253063676642168"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C6558T","G22865T","G28703A"],"N":["D144N"],"S":["A435S"],"nsp3":["A1280V"]},"labels":{"aa":"N: D144N; S: A435S; nsp3: A1280V","spike_mutations":"A435S"}}},{"name":"CD.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"CD.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.35979999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4365416773857803"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.31.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.5595383644104}},"branch_attrs":{"mutations":{"nuc":["C44T","G22899A","G23624A"],"S":["G446D","A688T"]},"labels":{"aa":"S: G446D, A688T","spike_mutations":"G446D, A688T"}}}]},{"name":"NODE_0001090","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.06477689743042}},"branch_attrs":{"mutations":{"nuc":["C18647T"],"nsp14":["P203L"]},"labels":{"aa":"nsp14: P203L"}},"children":[{"name":"BA.5.2.50","node_attrs":{"div":91,"Nextclade_pango":{"value":"BA.5.2.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.50"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.740553379058838}},"branch_attrs":{"mutations":{"nuc":["C7728T"],"nsp3":["S1670F"]},"labels":{"aa":"nsp3: S1670F"}}},{"name":"BA.5.2.51","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.51"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.90377140045166}},"branch_attrs":{"mutations":{"nuc":["A22893G","C29095T"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}}},{"name":"BA.5.2.60","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.60"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585160732269287}},"branch_attrs":{"mutations":{"nuc":["A11760G","A22910G"],"S":["N450D"],"nsp6":["K263R"]},"labels":{"aa":"S: N450D; nsp6: K263R","spike_mutations":"N450D"}}}]},{"name":"NODE_0001091","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.064579010009766}},"branch_attrs":{"mutations":{"nuc":["T2058C","C17958T","A22893T"],"S":["K444M"],"nsp2":["M418T"]},"labels":{"aa":"S: K444M; nsp2: M418T","spike_mutations":"K444M"}},"children":[{"name":"BA.5.2.7","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.064579010009766}},"branch_attrs":{"mutations":{}}},{"name":"CY.2","node_attrs":{"div":100,"Nextclade_pango":{"value":"CY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.36874999999999986"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["C106T","C3619T","C3695T","T7734G","C16954T","C18312T","C24759A","C28331T"],"N":["P20S"],"S":["T1066N"],"nsp3":["I1672S"]},"labels":{"aa":"N: P20S; S: T1066N; nsp3: I1672S","spike_mutations":"T1066N"}}},{"name":"CY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.7.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.679448127746582}},"branch_attrs":{"mutations":{"nuc":["C44T","T22942G","G27933A"],"ORF8":["A14T"],"S":["N460K"]},"labels":{"aa":"ORF8: A14T; S: N460K","spike_mutations":"N460K"}}}]},{"name":"NODE_0001092","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{"nuc":["C11355T"],"nsp6":["A128V"]},"labels":{"aa":"nsp6: A128V"}},"children":[{"name":"BA.5.2.16","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281840801239014}},"branch_attrs":{"mutations":{}}},{"name":"BU.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.205173492431641}},"branch_attrs":{"mutations":{"nuc":["C10335T","T21992-","A21993-","T21994-","A22893T","T22942G"],"S":["Y144-","K444M","N460K"],"nsp5":["A94V"]},"labels":{"aa":"S: Y144-, K444M, N460K; nsp5: A94V","spike_mutations":"Y144-, K444M, N460K"}}},{"name":"internal_2ba3","node_attrs":{"div":92,"Nextclade_pango":{"value":"BA.5.2.16"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C16332T","C25658T"],"ORF3a":["T89I"]},"labels":{"aa":"ORF3a: T89I"}},"children":[{"name":"BU.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BU.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BU.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"BU.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.16.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["T3960C","C18747T","A22003T","A22910G"],"S":["K147N","N450D"],"nsp3":["I414T"]},"labels":{"aa":"S: K147N, N450D; nsp3: I414T","spike_mutations":"K147N, N450D"}}}]}]},{"name":"internal_28cf","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.415645122528076}},"branch_attrs":{"mutations":{"nuc":["C1471T","T2698C","A22893C","A29700G"],"S":["K444T"]},"labels":{"aa":"S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BA.5.2.25","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.415645122528076}},"branch_attrs":{"mutations":{}}},{"name":"DB.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.35650110244751}},"branch_attrs":{"mutations":{"nuc":["C22450T","G22599C","T22942G","C27741T"],"S":["R346T","N460K"]},"labels":{"aa":"S: R346T, N460K","spike_mutations":"R346T, N460K"}}},{"name":"DB.3","node_attrs":{"div":105,"Nextclade_pango":{"value":"DB.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1348T","A2182G","C2334T","T14565G","T16950A","C18744T","G19542T","T21992-","A21993-","T21994-","G22599C","T22942A","C26151T","G28109A"],"S":["Y144-","R346T","N460K"],"nsp14":["M501I"],"nsp2":["A510V"]},"labels":{"aa":"S: Y144-, R346T, N460K; nsp14: M501I; nsp2: A510V","spike_mutations":"Y144-, R346T, N460K"}}},{"name":"DB.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"DB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.25.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.673305034637451}},"branch_attrs":{"mutations":{"nuc":["G22346T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]},{"name":"internal_93c4","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BA.5.2.18","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.033194065093994}},"branch_attrs":{"mutations":{}}},{"name":"CR.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45785000000000003"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.993546485900879}},"branch_attrs":{"mutations":{"nuc":["T21995C"],"S":["Y145H"]},"labels":{"aa":"S: Y145H","spike_mutations":"Y145H"}}},{"name":"NODE_0001096","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.665866374969482}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C"],"S":["Y144-","R346T"]},"labels":{"aa":"S: Y144-, R346T","spike_mutations":"Y144-, R346T"}},"children":[{"name":"CR.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.665866374969482}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001097","node_attrs":{"div":92,"Nextclade_pango":{"value":"CR.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3630194664001465}},"branch_attrs":{"mutations":{"nuc":["G15957T","C29730-","A29731-","C29732-","C29733-","T29760-","A29761-","C29762-","A29763-","G29764-","T29765-","G29766-","A29767-","A29768-","C29769-","A29770-","A29771-"]}},"children":[{"name":"CR.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CR.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.24480676651001}},"branch_attrs":{"mutations":{"nuc":["C3267T","C16954T","G21746A"],"S":["V62I"],"nsp3":["T183I"]},"labels":{"aa":"S: V62I; nsp3: T183I","spike_mutations":"V62I"}}},{"name":"CR.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CR.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40216999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1593T","T22896C","C26873T","G29402T","T29728-","T29729-"],"N":["D377Y"],"S":["V445A"],"nsp2":["S263F"]},"labels":{"aa":"N: D377Y; S: V445A; nsp2: S263F","spike_mutations":"V445A"}}},{"name":"CR.1.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"CR.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.18.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.921500205993652}},"branch_attrs":{"mutations":{"nuc":["A8040G","C22000A","T29665C","-29771A"],"S":["H146Q"],"nsp3":["D1774G"]},"labels":{"aa":"S: H146Q; nsp3: D1774G","spike_mutations":"H146Q"}}}]}]}]},{"name":"NODE_0001098","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{"nuc":["C2710T","C8626T","C16887T","T17208C"]}},"children":[{"name":"BA.5.2.48","node_attrs":{"div":93,"Nextclade_pango":{"value":"BA.5.2.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-06"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.131979465484619}},"branch_attrs":{"mutations":{}}},{"name":"DY.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7056260108947754}},"branch_attrs":{"mutations":{"nuc":["C20762T","A29868G"],"nsp16":["T35I"]},"labels":{"aa":"nsp16: T35I"}}},{"name":"NODE_0001099","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{"nuc":["C44T","G23270T"],"S":["A570S"]},"labels":{"aa":"S: A570S","spike_mutations":"A570S"}},"children":[{"name":"DY.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.1067352294921875}},"branch_attrs":{"mutations":{}}},{"name":"DY.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DY.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.796561241149902}},"branch_attrs":{"mutations":{"nuc":["A1208G","C18377T","A22001G"],"S":["K147E"],"nsp14":["T113I"],"nsp2":["M135V"]},"labels":{"aa":"S: K147E; nsp14: T113I; nsp2: M135V","spike_mutations":"K147E"}}}]},{"name":"NODE_0001100","node_attrs":{"div":94,"Nextclade_pango":{"value":"BA.5.2.48"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8918910026550293}},"branch_attrs":{"mutations":{"nuc":["C11824T"]}},"children":[{"name":"DY.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"DY.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.5254948139190674}},"branch_attrs":{"mutations":{"nuc":["C28994A","A29868G"],"N":["Q241K"]},"labels":{"aa":"N: Q241K"}}},{"name":"DY.3","node_attrs":{"div":96,"Nextclade_pango":{"value":"DY.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.48.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7626357078552246}},"branch_attrs":{"mutations":{"nuc":["C4573T","C5628T"],"nsp3":["T970M"]},"labels":{"aa":"nsp3: T970M"}}}]}]},{"name":"internal_7385","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.6"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2117156982421875}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BA.5.2.6","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2117156982421875}},"branch_attrs":{"mutations":{}}},{"name":"CP.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"CP.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6942999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5295255377787571"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.206465721130371}},"branch_attrs":{"mutations":{"nuc":["G15025A","T21992-","A21993-","T21994-","C22564A","C23707T"],"S":["Y144-","N334K"],"nsp12":["A529T"]},"labels":{"aa":"S: Y144-, N334K; nsp12: A529T","spike_mutations":"Y144-, N334K"}}},{"name":"CP.4","node_attrs":{"div":93,"Nextclade_pango":{"value":"CP.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.632293224334717}},"branch_attrs":{"mutations":{"nuc":["C1387T","A13327G","A23870G"],"S":["I770V"]},"labels":{"aa":"S: I770V","spike_mutations":"I770V"}}},{"name":"CP.5","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.982746124267578}},"branch_attrs":{"mutations":{"nuc":["G25302T"],"S":["C1247F"]},"labels":{"aa":"S: C1247F","spike_mutations":"C1247F"}}},{"name":"CP.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"CP.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.38661"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5998825593744821"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.8310227394104}},"branch_attrs":{"mutations":{"nuc":["A10323G","A22940T"],"S":["N460Y"],"nsp5":["K90R"]},"labels":{"aa":"S: N460Y; nsp5: K90R","spike_mutations":"N460Y"}}},{"name":"CP.6","node_attrs":{"div":92,"Nextclade_pango":{"value":"CP.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.885945796966553}},"branch_attrs":{"mutations":{"nuc":["T10330C","G25352T","T26485-","T26486-"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CP.7","node_attrs":{"div":99,"Nextclade_pango":{"value":"CP.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C44T","T809C","T7831C","A23669T","A25531G","T26270C","T27384C","G27516T","G28048T"],"E":["I9T"],"ORF3a":["I47V"],"ORF7a":["E41D"],"ORF8":["R52I"],"S":["N703Y"],"nsp2":["Y2H"]},"labels":{"aa":"E: I9T; ORF3a: I47V; ORF7a: E41D; ORF8: R52I; S: N703Y; nsp2: Y2H","spike_mutations":"N703Y"}}},{"name":"internal_7ebe","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{"nuc":["C15240T","A15486G","A19283G","C28651T"],"nsp14":["D415G"]},"labels":{"aa":"nsp14: D415G"}},"children":[{"name":"CP.8","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.959288597106934}},"branch_attrs":{"mutations":{}}},{"name":"CP.8.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"CP.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.8.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C3140T","C3619T","C6255T","G6662A","C18568A","C23997G"],"S":["P812R"],"nsp14":["L177I"],"nsp3":["P141S","A1179V","V1315I"]},"labels":{"aa":"S: P812R; nsp14: L177I; nsp3: P141S, A1179V, V1315I","spike_mutations":"P812R"}}}]},{"name":"NODE_0001103","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.436225414276123}},"branch_attrs":{"mutations":{"nuc":["T26485-","T26486-","T27360C","T28240-","T28241-"],"ORF8":["V116-"]},"labels":{"aa":"ORF8: V116-"}},"children":[{"name":"CP.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.436225414276123}},"branch_attrs":{"mutations":{}}},{"name":"CP.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CP.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.319653511047363}},"branch_attrs":{"mutations":{"nuc":["C829T","C6606T","T6703C","A22012C"],"S":["K150N"],"nsp3":["S1296F"]},"labels":{"aa":"S: K150N; nsp3: S1296F","spike_mutations":"K150N"}}},{"name":"CP.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CP.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.3846282958984375}},"branch_attrs":{"mutations":{"nuc":["T8704C","T22896C","C27389T","T29524C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"CP.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"CP.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6003199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:117-122"},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6214095378573192"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.6.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C11355T","A12064G","T21992-","A21993-","T21994-","G22898A"],"S":["Y144-","G446S"],"nsp6":["A128V"]},"labels":{"aa":"S: Y144-, G446S; nsp6: A128V","spike_mutations":"Y144-, G446S"}}}]}]},{"name":"NODE_0001104","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.24"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.071214199066162}},"branch_attrs":{"mutations":{"nuc":["G22894T"],"S":["K444N"]},"labels":{"aa":"S: K444N","spike_mutations":"K444N"}},"children":[{"name":"BA.5.2.24","node_attrs":{"div":90,"Nextclade_pango":{"value":"BA.5.2.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.071214199066162}},"branch_attrs":{"mutations":{}}},{"name":"CK.3","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.241343975067139}},"branch_attrs":{"mutations":{"nuc":["T22942A","C27509T"],"ORF7a":["T39I"],"S":["N460K"]},"labels":{"aa":"ORF7a: T39I; S: N460K","spike_mutations":"N460K"}}},{"name":"internal_36cf","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.667091369628906}},"branch_attrs":{"mutations":{"nuc":["G26428T"],"E":["V62F"]},"labels":{"aa":"E: V62F"}},"children":[{"name":"CK.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40293000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.667091369628906}},"branch_attrs":{"mutations":{}}},{"name":"internal_3525","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.376060962677002}},"branch_attrs":{"mutations":{"nuc":["T22942G"],"S":["N460K"]},"labels":{"aa":"S: N460K","spike_mutations":"N460K"}},"children":[{"name":"CK.2.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.376060962677002}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001107","node_attrs":{"div":97,"Nextclade_pango":{"value":"CK.2.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{"nuc":["G2393A","C8389T","G10998A","C13423T","C22326T"],"S":["S255F"],"nsp2":["V530I"],"nsp6":["G9D"]},"labels":{"aa":"S: S255F; nsp2: V530I; nsp6: G9D","spike_mutations":"S255F"}},"children":[{"name":"CK.2.1.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"CK.2.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.201341152191162}},"branch_attrs":{"mutations":{}}},{"name":"DG.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DG.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.2.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["G22316A"],"S":["G252S"]},"labels":{"aa":"S: G252S","spike_mutations":"G252S"}}}]}]}]},{"name":"NODE_0001108","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.083750247955322}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22942G"],"S":["Y144-","N460K"]},"labels":{"aa":"S: Y144-, N460K","spike_mutations":"Y144-, N460K"}},"children":[{"name":"CK.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"CK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.083750247955322}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"NODE_0001109","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.607499599456787}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"CK.1.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"CK.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C9118T","A11462G","C15951T"],"nsp6":["M164V"]},"labels":{"aa":"nsp6: M164V"}}},{"name":"CK.1.4","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C10228T","T25519C","C25824T","C27741T"],"ORF3a":["F43L"]},"labels":{"aa":"ORF3a: F43L"}}}]},{"name":"NODE_0001110","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.002077102661133}},"branch_attrs":{"mutations":{"nuc":["G22104T"],"S":["G181V"]},"labels":{"aa":"S: G181V","spike_mutations":"G181V"}},"children":[{"name":"CK.1.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"CK.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.712399482727051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}},{"name":"CK.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"CK.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.71883"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.998206615447998}},"branch_attrs":{"mutations":{"nuc":["C8655T","-21992T","-21993A","-21994T","G22599C","G23383A"],"S":["-144Y","R346T"],"nsp4":["S34F"]},"labels":{"aa":"S: -144Y, R346T; nsp4: S34F","spike_mutations":"-144Y, R346T"}}}]},{"name":"NODE_0001111","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.022307395935059}},"branch_attrs":{"mutations":{"nuc":["A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"CK.1.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-07-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C5628T","G6742T","C8782T","G23522A"],"S":["E654K"],"nsp3":["T970M"]},"labels":{"aa":"S: E654K; nsp3: T970M","spike_mutations":"E654K"}}},{"name":"CK.1.1.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"CK.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.657642364501953}},"branch_attrs":{"mutations":{"nuc":["C44T","G25352T","C26907T","A27753C"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}}},{"name":"CK.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CK.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.2.24.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.022307395935059}},"branch_attrs":{"mutations":{}}}]}]}]}]}]}]}]}]},{"name":"NODE_0001112","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161224365234375}},"branch_attrs":{"mutations":{"nuc":["C1931A"],"nsp2":["Q376K"]},"labels":{"aa":"nsp2: Q376K"}},"children":[{"name":"BA.5.3","node_attrs":{"div":83,"Nextclade_pango":{"value":"BA.5.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":51},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-29"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.161224365234375}},"branch_attrs":{"mutations":{}}},{"name":"BA.5.3.3","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:72-122"},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.7826626300811768}},"branch_attrs":{"mutations":{"nuc":["T2C","G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C6843T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"nsp1":["G82-","H83-","V84-","M85-","V86-"],"nsp3":["S1375F"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; nsp1: G82-, H83-, V84-, M85-, V86-; nsp3: S1375F"}}},{"name":"BA.5.3.5","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":36},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.3075408935546875}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","T519-","G520-","G521-","T522-","T523-","C13252T","G22599C","C27389T","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-"],"ORF7a":["A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-"],"S":["R346T"],"nsp1":["G82-","H83-","V84-","M85-","V86-"]},"labels":{"aa":"ORF7a: A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-; S: R346T; nsp1: G82-, H83-, V84-, M85-, V86-","spike_mutations":"R346T"}}},{"name":"NODE_0001113","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8096206188201904}},"branch_attrs":{"mutations":{"nuc":["C11074T"]}},"children":[{"name":"BA.5.3.2","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9212589263916016}},"branch_attrs":{"mutations":{"nuc":["G621A"],"nsp1":["R119H"]},"labels":{"aa":"nsp1: R119H"}}},{"name":"BA.5.3.4","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.250945091247559}},"branch_attrs":{"mutations":{"nuc":["G20718T"],"nsp16":["M20I"]},"labels":{"aa":"nsp16: M20I"}}}]},{"name":"NODE_0001114","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{"nuc":["G28681T"],"N":["E136D"]},"labels":{"aa":"N: E136D"}},"children":[{"name":"BA.5.3.1","node_attrs":{"div":84,"Nextclade_pango":{"value":"BA.5.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{}}},{"name":"BE.3","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-07-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.2200913429260254}},"branch_attrs":{"mutations":{"nuc":["A17207G","C17304T","C28724T"],"N":["P151S"],"nsp13":["Y324C"]},"labels":{"aa":"N: P151S; nsp13: Y324C"}}},{"name":"BE.5","node_attrs":{"div":84,"Nextclade_pango":{"value":"BE.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.5"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.261646270751953}},"branch_attrs":{"mutations":{}}},{"name":"BE.8","node_attrs":{"div":90,"Nextclade_pango":{"value":"BE.8"},"qc.stopCodons.totalStopCodons":{"value":1},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":94},"qc.overallScore":{"value":56.25},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.8"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.678462028503418}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C1853T","C14178T","C22498T","G22599C","C26110T","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-","A27748-","T28693C"],"ORF3a":["P240S"],"ORF7a":["Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-","K119*"],"S":["R346T"],"nsp1":["M85-"]},"labels":{"aa":"ORF3a: P240S; ORF7a: Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-, K119*; S: R346T; nsp1: M85-","spike_mutations":"R346T"}}},{"name":"NODE_0001115","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.4670610427856445}},"branch_attrs":{"mutations":{"nuc":["A22893C","T22942A"],"S":["K444T","N460K"]},"labels":{"aa":"S: K444T, N460K","spike_mutations":"K444T, N460K"}},"children":[{"name":"BE.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BE.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.10"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9143216609954834}},"branch_attrs":{"mutations":{"nuc":["C486T","C8730T","T11997C","C12919T","T14367C","A22942G","C26681T","C27393T"],"nsp1":["S74L"],"nsp4":["S59F"],"nsp7":["M52T"]},"labels":{"aa":"nsp1: S74L; nsp4: S59F; nsp7: M52T"}}},{"name":"BE.9","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.9"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.663193702697754}},"branch_attrs":{"mutations":{"nuc":["G515-","T516-","T517-","A518-","T519-","G520-","T21992-","A21993-","T21994-","T28693C"],"S":["Y144-"],"nsp1":["V84-","M85-"]},"labels":{"aa":"S: Y144-; nsp1: V84-, M85-","spike_mutations":"Y144-"}}}]},{"name":"NODE_0001116","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6816246509552}},"branch_attrs":{"mutations":{"nuc":["T28693C"]}},"children":[{"name":"BE.12","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.12"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.337923526763916}},"branch_attrs":{"mutations":{"nuc":["T224C","C10834T","T18975C","A29359G"]}}},{"name":"BE.11","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":52},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.11"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.008347988128662}},"branch_attrs":{"mutations":{"nuc":["T3049C","A29868G"]}}},{"name":"NODE_0001117","node_attrs":{"div":86,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.286231994628906}},"branch_attrs":{"mutations":{"nuc":["A518-","T519-","G520-","C22624T"],"nsp1":["M85-"]},"labels":{"aa":"nsp1: M85-"}},"children":[{"name":"BE.6","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5513799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.6"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.737891674041748}},"branch_attrs":{"mutations":{"nuc":["A22600T"],"S":["R346S"]},"labels":{"aa":"S: R346S","spike_mutations":"R346S"}}},{"name":"NODE_0001118","node_attrs":{"div":87,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.440604209899902}},"branch_attrs":{"mutations":{"nuc":["G22599C","A27508-","C27509-","A27510-","T27511-","A27512-","C27513-","G27514-","A27515-","G27516-","G27517-","G27518-","C27519-","A27520-","A27521-","T27522-","T27523-","C27524-","A27525-","C27526-","C27527-","A27528-","T27529-","T27530-","T27531-","C27532-","A27533-","T27534-","C27535-","C27536-","T27537-","C27538-","T27539-","A27540-","G27541-","C27542-","T27543-","G27544-","A27545-","T27546-","A27547-","A27548-","C27549-","A27550-","A27551-","A27552-","T27553-","T27554-","T27555-","G27556-","C27557-","A27558-","C27559-","T27560-","G27561-","A27562-","C27563-","T27564-","T27565-","G27566-","C27567-","T27568-","T27569-","T27570-","A27571-","G27572-","C27573-","A27574-","C27575-","T27576-","C27577-","A27578-","A27579-","T27580-","T27581-","T27582-","G27583-","C27584-","T27585-","T27586-","T27587-","T27588-","G27589-","C27590-","T27591-","T27592-","G27593-","T27594-","C27595-","C27596-","T27597-","G27598-","A27599-","C27600-","G27601-","G27602-","C27603-","G27604-","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","T27640-","C27641-","A27642-","C27643-","C27644-","T27645-","A27646-","A27647-","A27648-","C27649-","T27650-","G27651-","T27652-","T27653-","C27654-","A27655-","T27656-","C27657-","A27658-","G27659-","A27660-","C27661-","A27662-","A27663-","G27664-","A27665-","G27666-","G27667-","A27668-","A27669-","G27670-","T27671-","T27672-","C27673-","A27674-","A27675-","G27676-","A27677-","A27678-","C27679-","T27680-","T27681-","T27682-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-","C27739-","T27740-","C27741-","A27742-","A27743-","A27744-","A27745-","G27746-","A27747-"],"ORF7a":["T39-","Y40-","E41-","G42-","N43-","S44-","P45-","F46-","H47-","P48-","L49-","A50-","D51-","N52-","K53-","F54-","A55-","L56-","T57-","C58-","F59-","S60-","T61-","Q62-","F63-","A64-","F65-","A66-","C67-","P68-","D69-","G70-","V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-","S83-","P84-","K85-","L86-","F87-","I88-","R89-","Q90-","E91-","E92-","V93-","Q94-","E95-","L96-","Y97-","S98-","P99-","I100-","F101-","L102-","I103-","V104-","A105-","A106-","I107-","V108-","F109-","I110-","T111-","L112-","C113-","F114-","T115-","L116-","K117-","R118-"],"S":["R346T"]},"labels":{"aa":"ORF7a: T39-, Y40-, E41-, G42-, N43-, S44-, P45-, F46-, H47-, P48-, L49-, A50-, D51-, N52-, K53-, F54-, A55-, L56-, T57-, C58-, F59-, S60-, T61-, Q62-, F63-, A64-, F65-, A66-, C67-, P68-, D69-, G70-, V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-, S83-, P84-, K85-, L86-, F87-, I88-, R89-, Q90-, E91-, E92-, V93-, Q94-, E95-, L96-, Y97-, S98-, P99-, I100-, F101-, L102-, I103-, V104-, A105-, A106-, I107-, V108-, F109-, I110-, T111-, L112-, C113-, F114-, T115-, L116-, K117-, R118-; S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.13","node_attrs":{"div":94,"Nextclade_pango":{"value":"BE.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5231200000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5088823627149919"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.13"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.770232677459717}},"branch_attrs":{"mutations":{"nuc":["T516-","T517-","-519T","-520G","T2665C","C3176T","T22624C","A22995G","C23802T","A26170G","C27393T"],"ORF3a":["M260V"],"S":["K478R","T747I"],"nsp3":["P153S"]},"labels":{"aa":"ORF3a: M260V; S: K478R, T747I; nsp3: P153S","spike_mutations":"K478R, T747I"}}},{"name":"BE.7","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":95},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.7"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.440604209899902}},"branch_attrs":{"mutations":{}}}]}]}]},{"name":"NODE_0001119","node_attrs":{"div":85,"Nextclade_pango":{"value":"BA.5.3.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.679184913635254}},"branch_attrs":{"mutations":{"nuc":["C13342T"]}},"children":[{"name":"BE.2","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.8559343814849854}},"branch_attrs":{"mutations":{"nuc":["C2910T","A10399G"],"nsp3":["T64I"]},"labels":{"aa":"nsp3: T64I"}}},{"name":"NODE_0001120","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{"nuc":["C10188A","C27800T"],"nsp5":["T45N"]},"labels":{"aa":"nsp5: T45N"}},"children":[{"name":"BE.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.2494025230407715}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001121","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.281903266906738}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BE.4.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60741"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.614480018615723}},"branch_attrs":{"mutations":{"nuc":["G22894T","T22942G","C28453T"],"ORF9b":["A57V"],"S":["K444N","N460K"]},"labels":{"aa":"ORF9b: A57V; S: K444N, N460K","spike_mutations":"K444N, N460K"}}},{"name":"NODE_0001122","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{"nuc":["C3768T","C22188T","G22599C"],"S":["P209L","R346T"],"nsp3":["T350I"]},"labels":{"aa":"S: P209L, R346T; nsp3: T350I","spike_mutations":"P209L, R346T"}},"children":[{"name":"BE.4.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.530859470367432}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001123","node_attrs":{"div":92,"Nextclade_pango":{"value":"BE.4.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{"nuc":["A22893G"],"S":["K444R"]},"labels":{"aa":"S: K444R","spike_mutations":"K444R"}},"children":[{"name":"BE.4.1.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"BE.4.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.161832332611084}},"branch_attrs":{"mutations":{}}},{"name":"CQ.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"CQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.40216999999999997"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7986669946614685"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9200549125671387}},"branch_attrs":{"mutations":{"nuc":["C3686T","T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"],"nsp3":["H323Y"]},"labels":{"aa":"S: Y144-, V445A; nsp3: H323Y","spike_mutations":"Y144-, V445A"}}},{"name":"NODE_0001124","node_attrs":{"div":93,"Nextclade_pango":{"value":"CQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C11866T","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"CQ.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"CQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"CQ.1.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"CQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5692699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7114855353996671"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.4.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.685410976409912}},"branch_attrs":{"mutations":{"nuc":["C44T","G22346T","C28849T"],"S":["A262S"]},"labels":{"aa":"S: A262S","spike_mutations":"A262S"}}}]}]}]}]}]}]},{"name":"NODE_0001125","node_attrs":{"div":85,"Nextclade_pango":{"value":"BE.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.024914026260376}},"branch_attrs":{"mutations":{"nuc":["G16935A"],"nsp13":["M233I"]},"labels":{"aa":"nsp13: M233I"}},"children":[{"name":"BE.1","node_attrs":{"div":85,"Nextclade_pango":{"value":"BE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":53},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-05-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.024914026260376}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.3","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":17},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.9577126502990723}},"branch_attrs":{"mutations":{"nuc":["G510-","T511-","C512-","A513-","T514-","G515-","T516-","T517-","A518-","C1625T","G22021T","G25334C","C28725T"],"N":["P151L"],"S":["M153I","E1258Q"],"nsp1":["G82-","H83-","V84-","M85V"],"nsp2":["L274F"]},"labels":{"aa":"N: P151L; S: M153I, E1258Q; nsp1: G82-, H83-, V84-, M85V; nsp2: L274F","spike_mutations":"M153I, E1258Q"}}},{"name":"NODE_0001126","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.295690059661865}},"branch_attrs":{"mutations":{"nuc":["T2C","C1471T","G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BE.1.2","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.295690059661865}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001127","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.1.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{"nuc":["C2299A","T22896C","A29700G"],"S":["V445A"],"nsp2":["F498L"]},"labels":{"aa":"S: V445A; nsp2: F498L","spike_mutations":"V445A"}},"children":[{"name":"BE.1.2.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BE.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5026299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6938954632982287"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.283288478851318}},"branch_attrs":{"mutations":{}}},{"name":"DW.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49383999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8224959014481948"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.2.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["C1102T","C8772T","A22941G","T24511C"],"S":["N460S"],"nsp4":["T73I"]},"labels":{"aa":"S: N460S; nsp4: T73I","spike_mutations":"N460S"}}}]}]},{"name":"NODE_0001128","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{"nuc":["G376A","G18826A"],"nsp14":["V263I"]},"labels":{"aa":"nsp14: V263I"}},"children":[{"name":"BE.1.4","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.163514137268066}},"branch_attrs":{"mutations":{}}},{"name":"BE.1.4.4","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.4.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"BE.1.4.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BE.1.4.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.39120999999999995"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.48835193087700773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.3"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["A10108G","C12115T","T14133C","T22896C","C26111T","C28435T"],"ORF3a":["P240L"],"ORF9b":["P51L"],"S":["V445A"]},"labels":{"aa":"ORF3a: P240L; ORF9b: P51L; S: V445A","spike_mutations":"V445A"}}},{"name":"NODE_0001129","node_attrs":{"div":88,"Nextclade_pango":{"value":"BE.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.36769437789917}},"branch_attrs":{"mutations":{"nuc":["C25614T"]}},"children":[{"name":"BE.1.4.1","node_attrs":{"div":90,"Nextclade_pango":{"value":"BE.1.4.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.538283348083496}},"branch_attrs":{"mutations":{"nuc":["A1C","C23664T"],"S":["A701V"]},"labels":{"aa":"S: A701V","spike_mutations":"A701V"}}},{"name":"BE.1.4.2","node_attrs":{"div":93,"Nextclade_pango":{"value":"BE.1.4.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6697299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.4933085602270773"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.4.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.585708141326904}},"branch_attrs":{"mutations":{"nuc":["T10287C","A21137G","G22599C","C28170A","C28312T"],"ORF8":["P93T"],"ORF9b":["S10F"],"S":["R346T"],"nsp16":["K160R"],"nsp5":["I78T"]},"labels":{"aa":"ORF8: P93T; ORF9b: S10F; S: R346T; nsp16: K160R; nsp5: I78T","spike_mutations":"R346T"}}}]}]},{"name":"NODE_0001130","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7709906101226807}},"branch_attrs":{"mutations":{"nuc":["T2954C","C11750T"],"nsp6":["L260F"]},"labels":{"aa":"nsp6: L260F"}},"children":[{"name":"BE.1.1","node_attrs":{"div":87,"Nextclade_pango":{"value":"BE.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":54},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-06-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-2.7709906101226807}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001131","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{"nuc":["T6700C","C28432T"],"ORF9b":["S50L"]},"labels":{"aa":"ORF9b: S50L"}},"children":[{"name":"BE.1.1.2","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5583100000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.3000370340658239"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-3.6190600395202637}},"branch_attrs":{"mutations":{}}},{"name":"CC.1","node_attrs":{"div":92,"Nextclade_pango":{"value":"CC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.4997300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.40917808092175934"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.2.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-5.202326774597168}},"branch_attrs":{"mutations":{"nuc":["G3871T","T20631C","A22910G"],"S":["N450D"],"nsp3":["K384N"]},"labels":{"aa":"S: N450D; nsp3: K384N","spike_mutations":"N450D"}}}]},{"name":"BE.1.1_internal","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.037106990814209}},"branch_attrs":{"mutations":{"nuc":["A22893C","C28312T"],"ORF9b":["S10F"],"S":["K444T"]},"labels":{"aa":"ORF9b: S10F; S: K444T","spike_mutations":"K444T"}},"children":[{"name":"BE.1.1.1","node_attrs":{"div":89,"Nextclade_pango":{"value":"BE.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45952999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":55},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-08-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5608456933344607"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.037106990814209}},"branch_attrs":{"mutations":{}}},{"name":"BQ.2","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.45205000000000006"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":56},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.5680790723509552"},"clade_display":{"value":"22B (BA.5)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.2"},"clade_nextstrain":{"value":"22B"},"clade_membership":{"value":"22B"},"placement_prior":{"value":-4.677981853485107}},"branch_attrs":{"mutations":{"nuc":["G23126C","C29769T"],"S":["A522P"]},"labels":{"aa":"S: A522P","spike_mutations":"A522P"}}},{"name":"NODE_0001133","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3801355361938477}},"branch_attrs":{"mutations":{"nuc":["T14257C","T22942A"],"S":["N460K"],"nsp12":["Y273H"]},"labels":{"aa":"S: N460K; nsp12: Y273H","clade":"22E","spike_mutations":"N460K"}},"children":[{"name":"BQ.1","node_attrs":{"div":91,"Nextclade_pango":{"value":"BQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3801355361938477}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.14","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4368529319763184}},"branch_attrs":{"mutations":{"nuc":["C18570A"]}}},{"name":"BQ.1.12","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.12"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.3855841159820557}},"branch_attrs":{"mutations":{"nuc":["C28849T"]}}},{"name":"BQ.1.19","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6127800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7257362514460642"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.19"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.9549241065979}},"branch_attrs":{"mutations":{"nuc":["T23042C","A23370G"],"S":["S494P","N603S"]},"labels":{"aa":"S: S494P, N603S","spike_mutations":"S494P, N603S"}}},{"name":"BQ.1.17","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.57323"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.17"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.728287220001221}},"branch_attrs":{"mutations":{"nuc":["T5507C","C22893T"],"S":["T444M"]},"labels":{"aa":"S: T444M","spike_mutations":"T444M"}}},{"name":"BQ.1.20","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5446"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8308113969466171"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.20"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.457104682922363}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}},{"name":"BQ.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6570799999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.21"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.300747394561768}},"branch_attrs":{"mutations":{"nuc":["C6525T","T21992-","A21993-","T21994-","A22600C","C24844T","C25603T","T29726-"],"S":["Y144-","R346S"],"nsp3":["T1269I"]},"labels":{"aa":"S: Y144-, R346S; nsp3: T1269I","spike_mutations":"Y144-, R346S"}}},{"name":"BQ.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.24"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.424004077911377}},"branch_attrs":{"mutations":{"nuc":["C22281T","G22599C","G27987T"],"ORF8":["V32L"],"S":["T240I","R346T"]},"labels":{"aa":"ORF8: V32L; S: T240I, R346T","spike_mutations":"T240I, R346T"}}},{"name":"BQ.1.32","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9362235069274902}},"branch_attrs":{"mutations":{"nuc":["C4084T","T12667C","A22305C","C26833T","A28389T"],"M":["A104V"],"N":["Q39L"],"ORF9b":["N36Y"],"S":["Y248S"]},"labels":{"aa":"M: A104V; N: Q39L; ORF9b: N36Y; S: Y248S","spike_mutations":"Y248S"}}},{"name":"BQ.1.33","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.33"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.33"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.946379661560059}},"branch_attrs":{"mutations":{"nuc":["A22002T","C22033A","T22423C"],"S":["K147I","F157L"]},"labels":{"aa":"S: K147I, F157L","spike_mutations":"K147I, F157L"}}},{"name":"BQ.1.31","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.31"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.428726673126221}},"branch_attrs":{"mutations":{"nuc":["A22001G"],"S":["K147E"]},"labels":{"aa":"S: K147E","spike_mutations":"K147E"}}},{"name":"BQ.1.5","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.459336757659912}},"branch_attrs":{"mutations":{"nuc":["C16694T"],"nsp13":["T153I"]},"labels":{"aa":"nsp13: T153I"}}},{"name":"BQ.1.4","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C4276T","G8258A","T9100C","G22131C","G24415T","T29173G","C29870A"],"N":["H300Q"],"S":["R190T"],"nsp3":["V1847I"]},"labels":{"aa":"N: H300Q; S: R190T; nsp3: V1847I","spike_mutations":"R190T"}}},{"name":"BQ.1.7","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.914120197296143}},"branch_attrs":{"mutations":{"nuc":["G21724T"],"S":["L54F"]},"labels":{"aa":"S: L54F","spike_mutations":"L54F"}}},{"name":"BQ.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.6"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9833500385284424}},"branch_attrs":{"mutations":{"nuc":["G545T","C21622G","C26313T"],"nsp1":["G94C"]},"labels":{"aa":"nsp1: G94C"}}},{"name":"BQ.1.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.9"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.657703399658203}},"branch_attrs":{"mutations":{"nuc":["G8075A","G20469A","G22599C"],"S":["R346T"],"nsp3":["V1786I"]},"labels":{"aa":"S: R346T; nsp3: V1786I","spike_mutations":"R346T"}}},{"name":"NODE_0001134","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.11"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{"nuc":["C29541T"]}},"children":[{"name":"BQ.1.11.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.11.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["C593T","G1738T","G5164T","C21575T","T21992-","A21993-","T21994-","T24194C"],"S":["L5F","Y144-"],"nsp1":["H110Y"],"nsp3":["E815D"]},"labels":{"aa":"S: L5F, Y144-; nsp1: H110Y; nsp3: E815D","spike_mutations":"L5F, Y144-"}}},{"name":"BQ.1.11","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.761813163757324}},"branch_attrs":{"mutations":{}}}]},{"name":"NODE_0001135","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{"nuc":["T961C","G2144A"],"nsp2":["V447I"]},"labels":{"aa":"nsp2: V447I"}},"children":[{"name":"BQ.1.13","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.006511211395264}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.13.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.13.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7374401092529297}},"branch_attrs":{"mutations":{"nuc":["C7318T","T19266C","T21992-","A21993-","T21994-","C22033A","T26106C"],"S":["Y144-","F157L"]},"labels":{"aa":"S: Y144-, F157L","spike_mutations":"Y144-, F157L"}}}]},{"name":"NODE_0001136","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4062888622283936}},"branch_attrs":{"mutations":{"nuc":["A1777G","G6734A","C20429T","G25595T","T29492C"],"ORF3a":["R68I"],"nsp15":["P270L"],"nsp3":["V1339I"]},"labels":{"aa":"ORF3a: R68I; nsp15: P270L; nsp3: V1339I"}},"children":[{"name":"BQ.1.28","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2764058113098145}},"branch_attrs":{"mutations":{"nuc":["C44T","C25096T"]}}},{"name":"BQ.1.29","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.29"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["G23222C"],"S":["E554Q"]},"labels":{"aa":"S: E554Q","spike_mutations":"E554Q"}}}]},{"name":"NODE_0001137","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{"nuc":["C9611T"],"nsp4":["L353F"]},"labels":{"aa":"nsp4: L353F"}},"children":[{"name":"BQ.1.15","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.86649227142334}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001138","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.009603977203369}},"branch_attrs":{"mutations":{"nuc":["T2820C"],"nsp3":["V34A"]},"labels":{"aa":"nsp3: V34A"}},"children":[{"name":"BQ.1.15.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.15.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.0685200691223145}},"branch_attrs":{"mutations":{"nuc":["C44T","C17745T"]}}},{"name":"BQ.1.15.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.15.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.15.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.111164569854736}},"branch_attrs":{"mutations":{"nuc":["C6286T"]}}}]}]},{"name":"NODE_0001139","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.710926055908203}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A25897G","G26426T"],"E":["R61L"],"ORF3a":["I169V"],"S":["Y144-"]},"labels":{"aa":"E: R61L; ORF3a: I169V; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.26","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.710926055908203}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001140","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.26"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.898018836975098}},"branch_attrs":{"mutations":{"nuc":["G17721T"]}},"children":[{"name":"BQ.1.26.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.26.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G1008A","T27035C","G27798T"],"ORF7b":["A15S"],"nsp2":["S68N"]},"labels":{"aa":"ORF7b: A15S; nsp2: S68N"}}},{"name":"BQ.1.26.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.26.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.26.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}}}]}]},{"name":"internal_56b3","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["T8038C","C22855T","T25569C","G26031A"]}},"children":[{"name":"BQ.1.30","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.30"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["C44T","A10621G","T16635C","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_a61e","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.25"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.176206588745117}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.25","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.176206588745117}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.25.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.25.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.25.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8304200172424316}},"branch_attrs":{"mutations":{"nuc":["C24134A","C25553T"],"ORF3a":["A54V"],"S":["L858I"]},"labels":{"aa":"ORF3a: A54V; S: L858I","spike_mutations":"L858I"}}}]}]},{"name":"NODE_0001143","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{"nuc":["C10142A","G23417C"],"S":["E619Q"],"nsp5":["L30I"]},"labels":{"aa":"S: E619Q; nsp5: L30I","spike_mutations":"E619Q"}},"children":[{"name":"BQ.1.3.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7126309871673584}},"branch_attrs":{"mutations":{"nuc":["A1T","C2509T"]}}},{"name":"BQ.1.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.89422607421875}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.3.2","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.3.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4316980838775635}},"branch_attrs":{"mutations":{"nuc":["C5822T"],"nsp3":["L1035F"]},"labels":{"aa":"nsp3: L1035F"}}}]},{"name":"internal_BQ_1_10","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{"nuc":["C27600T"]}},"children":[{"name":"BQ.1.10","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":57},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9126851558685303}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.10.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.10.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.420897960662842}},"branch_attrs":{"mutations":{"nuc":["C6040T","C10798T","T10819C","A22001G","A25438G"],"ORF3a":["K16E"],"S":["K147E"]},"labels":{"aa":"ORF3a: K16E; S: K147E","spike_mutations":"K147E"}}},{"name":"NODE_0001145","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9055120944976807}},"branch_attrs":{"mutations":{"nuc":["A1320C","C3040T"],"nsp2":["E172A"]},"labels":{"aa":"nsp2: E172A"}},"children":[{"name":"BQ.1.10.2","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.10.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6353800000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6853534127590314"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.400434970855713}},"branch_attrs":{"mutations":{"nuc":["C9286T","C23130A"],"S":["T523N"]},"labels":{"aa":"S: T523N","spike_mutations":"T523N"}}},{"name":"internal_7569","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.10.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{"nuc":["A21999T"],"S":["H146L"]},"labels":{"aa":"S: H146L","spike_mutations":"H146L"}},"children":[{"name":"BQ.1.10.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.10.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.217254638671875}},"branch_attrs":{"mutations":{}}},{"name":"internal_9530","node_attrs":{"div":97,"Nextclade_pango":{"value":"EC.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{"nuc":["A3481T","G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"EC.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"EC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.1945013999938965}},"branch_attrs":{"mutations":{}}},{"name":"EC.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EC.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.10.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.57907772064209}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T22896C"],"S":["Y144-","V445A"]},"labels":{"aa":"S: Y144-, V445A","spike_mutations":"Y144-, V445A"}}}]}]}]}]},{"name":"internal_1083","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4688456058502197}},"branch_attrs":{"mutations":{"nuc":["A23558G"],"S":["I666V"]},"labels":{"aa":"S: I666V","spike_mutations":"I666V"}},"children":[{"name":"BQ.1.2","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4688456058502197}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.2.3","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.2.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875691413879395}},"branch_attrs":{"mutations":{"nuc":["G26314C"],"E":["V24L"]},"labels":{"aa":"E: V24L"}}},{"name":"NODE_0001149","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","T516-","T517-","A22001G","G22599C","T22896C","G26951C","C28163A"],"ORF8":["C90*"],"S":["K147E","R346T","V445A"]},"labels":{"aa":"ORF8: C90*; S: K147E, R346T, V445A","spike_mutations":"K147E, R346T, V445A"}},"children":[{"name":"JH.1","node_attrs":{"div":105,"Nextclade_pango":{"value":"JH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66664"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9874397743924017"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A518-","G19129A","A22106G","C22314T","T23019C","T23042C","G23222A","G26158-","T26159-","T26160-","A26161-","A26162-","T26163-","C26164-","C26165-","A26166-","G26167-","T26168-","A26169-","G29779T"],"ORF3a":["V255-","V256-","N257-","P258-"],"S":["K182E","P251L","V486A","S494P","E554K"],"nsp1":["M85-"],"nsp14":["E364K"]},"labels":{"aa":"ORF3a: V255-, V256-, N257-, P258-; S: K182E, P251L, V486A, S494P, E554K; nsp1: M85-; nsp14: E364K","spike_mutations":"K182E, P251L, V486A, S494P, E554K"}}},{"name":"NODE_0001150","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.2.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{"nuc":["G509-","G510-","T511-","C512-","A513-","T514-","G515-","G4255A","T22119-","C22120-","A22121-","A22122-","A22123-","A22124-"],"S":["F186-","K187-","N188Y"],"nsp1":["G82-","H83-","V84-"]},"labels":{"aa":"S: F186-, K187-, N188Y; nsp1: G82-, H83-, V84-","spike_mutations":"F186-, K187-, N188Y"}},"children":[{"name":"BQ.1.2.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.2.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":19},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.000681400299072}},"branch_attrs":{"mutations":{}}},{"name":"JH.2","node_attrs":{"div":109,"Nextclade_pango":{"value":"JH.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6059300000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":67},"totalAminoacidDeletions":{"value":31},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF7a:83-122"},"designation_date":{"value":"2023-08-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.0821590912755812"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.2.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C2003T","C2453T","G8368A","G14857T","A17824G","T23011A","G23012A","C23013A","T23019C","A25983G","T27605-","A27606-","A27607-","A27608-","A27609-","C27610-","A27611-","C27612-","G27613-","T27614-","C27615-","T27616-","A27617-","T27618-","C27619-","A27620-","G27621-","T27622-","T27623-","A27624-","C27625-","G27626-","T27627-","G27628-","C27629-","C27630-","A27631-","G27632-","A27633-","T27634-","C27635-","A27636-","G27637-","T27638-","T27639-","A27683-","C27684-","T27685-","C27686-","T27687-","C27688-","C27689-","A27690-","A27691-","T27692-","T27693-","T27694-","T27695-","T27696-","C27697-","T27698-","T27699-","A27700-","T27701-","T27702-","G27703-","T27704-","T27705-","G27706-","C27707-","G27708-","G27709-","C27710-","A27711-","A27712-","T27713-","A27714-","G27715-","T27716-","G27717-","T27718-","T27719-","T27720-","A27721-","T27722-","A27723-","A27724-","C27725-","A27726-","C27727-","T27728-","T27729-","T27730-","G27731-","C27732-","T27733-","T27734-","C27735-","A27736-","C27737-","A27738-"],"ORF7a":["V71-","K72-","H73-","V74-","Y75-","Q76-","L77-","R78-","A79-","R80-","S81-","V82-"],"S":["A484K","V486A"],"nsp12":["V473F"],"nsp13":["T530A"],"nsp2":["L400F","L550F"]},"labels":{"aa":"ORF7a: V71-, K72-, H73-, V74-, Y75-, Q76-, L77-, R78-, A79-, R80-, S81-, V82-; S: A484K, V486A; nsp12: V473F; nsp13: T530A; nsp2: L400F, L550F","spike_mutations":"A484K, V486A"}}}]}]},{"name":"internal_dbfb","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{"nuc":["A4414G","C15960A","C17746T","T21992-","A21993-","T21994-","C27513T","C29171A","A29868G"],"N":["H300N"],"S":["Y144-"],"nsp13":["P504S"]},"labels":{"aa":"N: H300N; S: Y144-; nsp13: P504S","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.2.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.2.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.234764575958252}},"branch_attrs":{"mutations":{}}},{"name":"FB.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"FB.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5174000000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6925976779449897"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3243A","T10771C","A22995G"],"S":["K478R"],"nsp3":["G175D"]},"labels":{"aa":"S: K478R; nsp3: G175D","spike_mutations":"K478R"}}},{"name":"FB.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"FB.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.2.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["A14-","T18-","C19-","C20-","C21-","A22-","G23-","G24-","A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}}]}]},{"name":"internal_efa8","node_attrs":{"div":92,"Nextclade_pango":{"value":"BQ.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.758645534515381}},"branch_attrs":{"mutations":{"nuc":["A17039G"],"nsp13":["N268S"]},"labels":{"aa":"nsp13: N268S"}},"children":[{"name":"BQ.1.18","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.5464024543762207}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22599C","C26455T"],"E":["P71S"],"S":["Y144-","R346T"]},"labels":{"aa":"E: P71S; S: Y144-, R346T","spike_mutations":"Y144-, R346T"}}},{"name":"BQ.1.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-13"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.16"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.505335330963135}},"branch_attrs":{"mutations":{"nuc":["C1884T","C19875T"],"nsp2":["A360V"]},"labels":{"aa":"nsp2: A360V"}}},{"name":"BQ.1.23","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":58},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.23"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4521589279174805}},"branch_attrs":{"mutations":{"nuc":["A2653G","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.22","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.057005882263184}},"branch_attrs":{"mutations":{"nuc":["C44T","G22599C","C26681T"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}}},{"name":"BQ.1.27","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.49690999999999996"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.7651005091732451"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.27"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.637411117553711}},"branch_attrs":{"mutations":{"nuc":["T22896C","T29599C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"internal_10e8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{"nuc":["C1779T","C7735T","C8251T","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp2":["S325F"]},"labels":{"aa":"S: Y144-; nsp2: S325F","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6875174045562744}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.8.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.8.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C21575T","C22329T","C29708T"],"S":["L5F","S256L"]},"labels":{"aa":"S: L5F, S256L","spike_mutations":"L5F, S256L"}}},{"name":"internal_9a91","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.8.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{"nuc":["C12115T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}},"children":[{"name":"BQ.1.8.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.8.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.638953685760498}},"branch_attrs":{"mutations":{}}},{"name":"FF.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66401"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.6765077176301588"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.8.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A1451G","C17999T","C22329T","G23401T","G25052A"],"S":["S256L","Q613H","V1164I"],"nsp13":["T588I"],"nsp2":["I216V"]},"labels":{"aa":"S: S256L, Q613H, V1164I; nsp13: T588I; nsp2: I216V","spike_mutations":"S256L, Q613H, V1164I"}}}]}]},{"name":"NODE_0001155","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.39292049407959}},"branch_attrs":{"mutations":{"nuc":["G22599C"],"S":["R346T"]},"labels":{"aa":"S: R346T","spike_mutations":"R346T"}},"children":[{"name":"BQ.1.1","node_attrs":{"div":93,"Nextclade_pango":{"value":"BQ.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-09-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-2.39292049407959}},"branch_attrs":{"mutations":{}}},{"name":"BQ.1.1.11","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.11"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.11"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8915650844573975}},"branch_attrs":{"mutations":{"nuc":["T23042C"],"S":["S494P"]},"labels":{"aa":"S: S494P","spike_mutations":"S494P"}}},{"name":"BQ.1.1.12","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.12"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.12"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.535731792449951}},"branch_attrs":{"mutations":{"nuc":["C13368T","T23042C"],"S":["S494P"],"nsp10":["T115I"]},"labels":{"aa":"S: S494P; nsp10: T115I","spike_mutations":"S494P"}}},{"name":"BQ.1.1.17","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.17"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.17"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.149693012237549}},"branch_attrs":{"mutations":{"nuc":["C7083T"],"nsp3":["S1455F"]},"labels":{"aa":"nsp3: S1455F"}}},{"name":"BQ.1.1.16","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.16"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.16"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.612196922302246}},"branch_attrs":{"mutations":{"nuc":["G23383T"],"S":["Q607H"]},"labels":{"aa":"S: Q607H","spike_mutations":"Q607H"}}},{"name":"BQ.1.1.20","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.20"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.20"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.5311388969421387}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C26002T","G27047T"],"ORF3a":["H204Y"],"S":["Y144-"]},"labels":{"aa":"ORF3a: H204Y; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.19","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.19"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.19"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.22513484954834}},"branch_attrs":{"mutations":{"nuc":["A29413T"],"N":["Q380H"]},"labels":{"aa":"N: Q380H"}}},{"name":"BQ.1.1.21","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.21"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"frameShifts":{"value":"ORF8:122"},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.21"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.871743679046631}},"branch_attrs":{"mutations":{"nuc":["A17946G","T21992-","A21993-","T21994-","A28254-","A28761G"],"N":["Q163R"],"ORF8":["I121-"],"S":["Y144-"]},"labels":{"aa":"N: Q163R; ORF8: I121-; S: Y144-","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.24","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.24"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.24"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.991058826446533}},"branch_attrs":{"mutations":{"nuc":["C11941T"]}}},{"name":"BQ.1.1.25","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.25"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7449699999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.25"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.073467254638672}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","T23031C"],"S":["Y144-","F490S"]},"labels":{"aa":"S: Y144-, F490S","spike_mutations":"Y144-, F490S"}}},{"name":"BQ.1.1.26","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.26"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5921799999999998"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-01"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8728938682420008"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.26"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.841221332550049}},"branch_attrs":{"mutations":{"nuc":["T19224C","G22973C","A25712G"],"ORF3a":["Y107C"],"S":["E471Q"]},"labels":{"aa":"ORF3a: Y107C; S: E471Q","spike_mutations":"E471Q"}}},{"name":"BQ.1.1.31","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.31"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.31"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8330674171447754}},"branch_attrs":{"mutations":{"nuc":["C22329T"],"S":["S256L"]},"labels":{"aa":"S: S256L","spike_mutations":"S256L"}}},{"name":"BQ.1.1.30","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.30"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.60833"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9373817650831857"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.30"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.600118160247803}},"branch_attrs":{"mutations":{"nuc":["C12763T","T22896C"],"S":["V445A"]},"labels":{"aa":"S: V445A","spike_mutations":"V445A"}}},{"name":"BQ.1.1.34","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.34"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.34"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.100788593292236}},"branch_attrs":{"mutations":{"nuc":["C7528T","T21992-","A21993-","T21994-","T23042C"],"S":["Y144-","S494P"]},"labels":{"aa":"S: Y144-, S494P","spike_mutations":"Y144-, S494P"}}},{"name":"BQ.1.1.36","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.36"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.36"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.201074600219727}},"branch_attrs":{"mutations":{"nuc":["C24210T"],"S":["T883I"]},"labels":{"aa":"S: T883I","spike_mutations":"T883I"}}},{"name":"BQ.1.1.37","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.37"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.37"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.314393997192383}},"branch_attrs":{"mutations":{"nuc":["T1453C"]}}},{"name":"BQ.1.1.40","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.40"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.40"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9316465854644775}},"branch_attrs":{"mutations":{"nuc":["C28344T"],"N":["T24I"]},"labels":{"aa":"N: T24I"}}},{"name":"BQ.1.1.42","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.42"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.42"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2274322509765625}},"branch_attrs":{"mutations":{"nuc":["G872A","T21992-","A21993-","T21994-","C23673T"],"S":["Y144-","S704L"],"nsp2":["D23N"]},"labels":{"aa":"S: Y144-, S704L; nsp2: D23N","spike_mutations":"Y144-, S704L"}}},{"name":"BQ.1.1.41","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.41"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.41"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9046711921691895}},"branch_attrs":{"mutations":{"nuc":["C7851T","C18162T","A22107T","T24142C"],"S":["K182I"],"nsp3":["A1711V"]},"labels":{"aa":"S: K182I; nsp3: A1711V","spike_mutations":"K182I"}}},{"name":"BQ.1.1.44","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.44"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.44"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.068450927734375}},"branch_attrs":{"mutations":{"nuc":["A22320G"],"S":["D253G"]},"labels":{"aa":"S: D253G","spike_mutations":"D253G"}}},{"name":"BQ.1.1.47","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.47"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.47"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.249934673309326}},"branch_attrs":{"mutations":{"nuc":["G9854A","A22002T"],"S":["K147I"],"nsp4":["V434M"]},"labels":{"aa":"S: K147I; nsp4: V434M","spike_mutations":"K147I"}}},{"name":"BQ.1.1.45","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.45"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.45"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.7044405937194824}},"branch_attrs":{"mutations":{"nuc":["T22304G"],"S":["Y248D"]},"labels":{"aa":"S: Y248D","spike_mutations":"Y248D"}}},{"name":"BQ.1.1.50","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.50"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":16},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.50"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.386298179626465}},"branch_attrs":{"mutations":{"nuc":["A2271G","C15842T","T18159C","T21992-","A21993-","T21994-","A22190-","T22191-","T22192-"],"S":["Y144-","I210-"],"nsp12":["T801I"],"nsp2":["K489R"]},"labels":{"aa":"S: Y144-, I210-; nsp12: T801I; nsp2: K489R","spike_mutations":"Y144-, I210-"}}},{"name":"BQ.1.1.51","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.51"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.51"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9954097270965576}},"branch_attrs":{"mutations":{"nuc":["A1G","C25693T"],"ORF3a":["L101F"]},"labels":{"aa":"ORF3a: L101F"}}},{"name":"BQ.1.1.56","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.56"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.56"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.530673980712891}},"branch_attrs":{"mutations":{"nuc":["C24863T"],"S":["H1101Y"]},"labels":{"aa":"S: H1101Y","spike_mutations":"H1101Y"}}},{"name":"BQ.1.1.57","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.57"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.57"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.360785007476807}},"branch_attrs":{"mutations":{"nuc":["T22328G","C29541T"],"S":["S256A"]},"labels":{"aa":"S: S256A","spike_mutations":"S256A"}}},{"name":"BQ.1.1.55","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.55"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.55"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.861405849456787}},"branch_attrs":{"mutations":{"nuc":["T21889G","T21992-","A21993-","T21994-","A25008G"],"S":["Y144-","K1149R"]},"labels":{"aa":"S: Y144-, K1149R","spike_mutations":"Y144-, K1149R"}}},{"name":"BQ.1.1.58","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.58"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.58"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.378433704376221}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","A24362G"],"S":["Y144-","I934V"]},"labels":{"aa":"S: Y144-, I934V","spike_mutations":"Y144-, I934V"}}},{"name":"BQ.1.1.60","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.60"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.60"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.21677827835083}},"branch_attrs":{"mutations":{"nuc":["C23634T","G28077T"],"ORF8":["V62L"],"S":["S691F"]},"labels":{"aa":"ORF8: V62L; S: S691F","spike_mutations":"S691F"}}},{"name":"BQ.1.1.6","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.6"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.6"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9752705097198486}},"branch_attrs":{"mutations":{"nuc":["C2306T"],"nsp2":["L501F"]},"labels":{"aa":"nsp2: L501F"}}},{"name":"BQ.1.1.63","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.63"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.63"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.371273994445801}},"branch_attrs":{"mutations":{"nuc":["C18981T","G19021A","T22304C"],"S":["Y248H"],"nsp14":["V328I"]},"labels":{"aa":"S: Y248H; nsp14: V328I","spike_mutations":"Y248H"}}},{"name":"BQ.1.1.64","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.64"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.64"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.916878700256348}},"branch_attrs":{"mutations":{"nuc":["C106T","G1999T","T22119C"],"S":["F186S"]},"labels":{"aa":"S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.66","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.66"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.66"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.276081562042236}},"branch_attrs":{"mutations":{"nuc":["A22003T","T29855C"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}}},{"name":"BQ.1.1.67","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.67"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.67"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.056059837341309}},"branch_attrs":{"mutations":{"nuc":["C5907T","C6726T","C22088T"],"S":["L176F"],"nsp3":["T1063I","T1336I"]},"labels":{"aa":"S: L176F; nsp3: T1063I, T1336I","spike_mutations":"L176F"}}},{"name":"BQ.1.1.68","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.68"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.68"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.0179033279418945}},"branch_attrs":{"mutations":{"nuc":["G3896A","C26822T"],"nsp3":["V393I"]},"labels":{"aa":"nsp3: V393I"}}},{"name":"BQ.1.1.69","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.69"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.69"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.636171579360962}},"branch_attrs":{"mutations":{"nuc":["C19547T"],"nsp14":["S503L"]},"labels":{"aa":"nsp14: S503L"}}},{"name":"BQ.1.1.70","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.70"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.70"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8411405086517334}},"branch_attrs":{"mutations":{"nuc":["C2973T","A27156G"],"M":["S212G"],"nsp3":["A85V"]},"labels":{"aa":"M: S212G; nsp3: A85V"}}},{"name":"BQ.1.1.73","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.73"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.73"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T10441C","T16533C","A22001G","A22182G"],"S":["K147E","H207R"]},"labels":{"aa":"S: K147E, H207R","spike_mutations":"K147E, H207R"}}},{"name":"BQ.1.1.75","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.75"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"-0.04867000000000007"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"1.051732686328446"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.75"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.3638596534729}},"branch_attrs":{"mutations":{"nuc":["C15540T","C15738T","T19026C","A22108C","T22928C","A25168G","G25855T"],"ORF3a":["D155Y"],"S":["K182N","F456L"]},"labels":{"aa":"ORF3a: D155Y; S: K182N, F456L","spike_mutations":"K182N, F456L"}}},{"name":"BQ.1.1.76","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.76"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.76"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.2394514083862305}},"branch_attrs":{"mutations":{"nuc":["C15180T"]}}},{"name":"BQ.1.1.77","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.77"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.77"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.662407398223877}},"branch_attrs":{"mutations":{"nuc":["C12853T","C17750T","T21992-","A21993-","T21994-"],"S":["Y144-"],"nsp13":["A505V"]},"labels":{"aa":"S: Y144-; nsp13: A505V","spike_mutations":"Y144-"}}},{"name":"BQ.1.1.9","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.9"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.9"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.7311859130859375}},"branch_attrs":{"mutations":{"nuc":["G22014T"],"S":["S151I"]},"labels":{"aa":"S: S151I","spike_mutations":"S151I"}}},{"name":"internal_7361","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.14"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.20283317565918}},"branch_attrs":{"mutations":{"nuc":["G23608T"]}},"children":[{"name":"BQ.1.1.14","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.14"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.20283317565918}},"branch_attrs":{"mutations":{}}},{"name":"CW.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"CW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.70602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":25},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.14.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.6625657081604}},"branch_attrs":{"mutations":{"nuc":["G425-","T426-","A427-","G428-","A429-","A430-","G431-","T432-","T433-","G434-","A435-","A436-","A437-","A438-","A439-","G440-","G441-","C442-","G443-","T444-","T445-","T446-","T447-","G448-","C449-","C450-","T451-","C452-","A453-","A454-","C455-","T456-","T457-","G22898A"],"S":["G446S"],"nsp1":["L53-","V54-","E55-","V56-","E57-","K58-","G59-","V60-","L61-","P62-","Q63-"]},"labels":{"aa":"S: G446S; nsp1: L53-, V54-, E55-, V56-, E57-, K58-, G59-, V60-, L61-, P62-, Q63-","spike_mutations":"G446S"}}}]},{"name":"NODE_0001157","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.15"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{"nuc":["T18897C"]}},"children":[{"name":"BQ.1.1.15","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.15"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.995543956756592}},"branch_attrs":{"mutations":{}}},{"name":"DM.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"DM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.65602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.15.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.9605560302734375}},"branch_attrs":{"mutations":{"nuc":["G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001158","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.2"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{"nuc":["A22320G","G27430A"],"ORF7a":["A13T"],"S":["D253G"]},"labels":{"aa":"ORF7a: A13T; S: D253G","spike_mutations":"D253G"}},"children":[{"name":"BQ.1.1.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.09950065612793}},"branch_attrs":{"mutations":{}}},{"name":"DU.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DU.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.2.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.10858678817749}},"branch_attrs":{"mutations":{"nuc":["T10003C","G24992C"],"S":["E1144Q"]},"labels":{"aa":"S: E1144Q","spike_mutations":"E1144Q"}}}]},{"name":"NODE_0001159","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.942479372024536}},"branch_attrs":{"mutations":{"nuc":["G6421T"]}},"children":[{"name":"BQ.1.1.23","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.23"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.23"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.781022071838379}},"branch_attrs":{"mutations":{"nuc":["G25681A","T29867A"],"ORF3a":["V97I"]},"labels":{"aa":"ORF3a: V97I"}}},{"name":"BQ.1.1.27","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.27"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-02"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.27"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.530292510986328}},"branch_attrs":{"mutations":{"nuc":["T8855C","G22103A"],"S":["G181R"],"nsp4":["F101L"]},"labels":{"aa":"S: G181R; nsp4: F101L","spike_mutations":"G181R"}}}]},{"name":"NODE_0001160","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.500977516174316}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.29","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.29"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.29"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.409616947174072}},"branch_attrs":{"mutations":{"nuc":["G7850A","T11374C"],"nsp3":["A1711T"]},"labels":{"aa":"nsp3: A1711T"}}},{"name":"BQ.1.1.79","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.79"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.79"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.523560047149658}},"branch_attrs":{"mutations":{"nuc":["C1594T","C16362T","T24079C","A29868G"]}}}]},{"name":"internal_5abd","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.35"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{"nuc":["C601T","G5699A","T8719C","A22001G"],"S":["K147E"],"nsp3":["A994T"]},"labels":{"aa":"S: K147E; nsp3: A994T","spike_mutations":"K147E"}},"children":[{"name":"BQ.1.1.35","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1.35"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-14"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504674911499023}},"branch_attrs":{"mutations":{}}},{"name":"ET.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"ET.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-16"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.35.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.596989154815674}},"branch_attrs":{"mutations":{"nuc":["T9619C","A22108T"],"S":["K182N"]},"labels":{"aa":"S: K182N","spike_mutations":"K182N"}}}]},{"name":"NODE_0001162","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.65"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{"nuc":["A22002T","C28677T"],"N":["T135I"],"S":["K147I"]},"labels":{"aa":"N: T135I; S: K147I","spike_mutations":"K147I"}},"children":[{"name":"BQ.1.1.65","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.65"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478107452392578}},"branch_attrs":{"mutations":{}}},{"name":"ES.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"ES.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.65.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.675690650939941}},"branch_attrs":{"mutations":{"nuc":["C44T","A21717G"],"S":["Q52R"]},"labels":{"aa":"S: Q52R","spike_mutations":"Q52R"}}}]},{"name":"NODE_0001163","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.7"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{"nuc":["C912A"],"nsp2":["S36Y"]},"labels":{"aa":"nsp2: S36Y"}},"children":[{"name":"BQ.1.1.7","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.7"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.848642110824585}},"branch_attrs":{"mutations":{}}},{"name":"DK.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DK.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.74371"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8470101435700336"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.7.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.994874477386475}},"branch_attrs":{"mutations":{"nuc":["G5690A","G22577A"],"S":["D339N"],"nsp3":["A991T"]},"labels":{"aa":"S: D339N; nsp3: A991T","spike_mutations":"D339N"}}}]},{"name":"internal_d988","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.72"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.452545642852783}},"branch_attrs":{"mutations":{"nuc":["A13766C"],"nsp12":["D109A"]},"labels":{"aa":"nsp12: D109A"}},"children":[{"name":"BQ.1.1.72","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.72"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.452545642852783}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}}},{"name":"FC.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FC.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.72.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.918569087982178}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"internal_bf35","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.74"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.695055961608887}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"BQ.1.1.74","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.74"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.695055961608887}},"branch_attrs":{"mutations":{}}},{"name":"FN.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"FN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.74.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["G3955A","C16767T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001166","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.8"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.212834358215332}},"branch_attrs":{"mutations":{"nuc":["C1385T","C3170T"],"nsp2":["H194Y"],"nsp3":["L151F"]},"labels":{"aa":"nsp2: H194Y; nsp3: L151F"}},"children":[{"name":"BQ.1.1.8","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.8"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.212834358215332}},"branch_attrs":{"mutations":{}}},{"name":"DP.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DP.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.66913"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9105813557217661"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.8.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.242037296295166}},"branch_attrs":{"mutations":{"nuc":["G22616T","C29353T"],"S":["A352S"]},"labels":{"aa":"S: A352S","spike_mutations":"A352S"}}}]},{"name":"NODE_0001167","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.10"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9088196754455566}},"branch_attrs":{"mutations":{"nuc":["T16413C","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.10","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.10"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.9088196754455566}},"branch_attrs":{"mutations":{}}},{"name":"FA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"FA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.81001615524292}},"branch_attrs":{"mutations":{"nuc":["A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"FA.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"FA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.10.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.999459743499756}},"branch_attrs":{"mutations":{"nuc":["C14583T","C22530T","C26058T"],"S":["T323I"]},"labels":{"aa":"S: T323I","spike_mutations":"T323I"}}}]},{"name":"internal_edc4","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8035850524902344}},"branch_attrs":{"mutations":{"nuc":["T18383C","T29867A"],"nsp14":["V115A"]},"labels":{"aa":"nsp14: V115A"}},"children":[{"name":"BQ.1.1.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-15"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8035850524902344}},"branch_attrs":{"mutations":{}}},{"name":"CZ.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"CZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6774299999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9883317000263399"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["C44T","C1549T","T13298C","T23030A"],"S":["F490I"]},"labels":{"aa":"S: F490I","spike_mutations":"F490I"}}},{"name":"CZ.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"CZ.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.435019016265869}},"branch_attrs":{"mutations":{"nuc":["C2462T","C23625T"],"S":["A688V"]},"labels":{"aa":"S: A688V","spike_mutations":"A688V"}}}]},{"name":"NODE_0001169","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.22"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{"nuc":["C913A","T21992-","A21993-","T21994-"],"S":["Y144-"]},"labels":{"aa":"S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.22","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.22"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-11-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.109969615936279}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001170","node_attrs":{"div":95,"Nextclade_pango":{"value":"ER.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{"nuc":["T22328C"],"S":["S256P"]},"labels":{"aa":"S: S256P","spike_mutations":"S256P"}},"children":[{"name":"ER.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"ER.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-05"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.952063083648682}},"branch_attrs":{"mutations":{}}},{"name":"ER.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"ER.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.22.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["C1346T","G5008T","G22331A","C28005T"],"ORF8":["P38S"],"S":["G257S"],"nsp2":["P181S"]},"labels":{"aa":"ORF8: P38S; S: G257S; nsp2: P181S","spike_mutations":"G257S"}}}]}]},{"name":"NODE_0001171","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{"nuc":["A15111G"]}},"children":[{"name":"BQ.1.1.3","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6778953075408936}},"branch_attrs":{"mutations":{}}},{"name":"DR.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"DR.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.548947811126709}},"branch_attrs":{"mutations":{"nuc":["C44T","T21992-","A21993-","T21994-","G22021T"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}}},{"name":"DR.2","node_attrs":{"div":97,"Nextclade_pango":{"value":"DR.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.3.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.494004726409912}},"branch_attrs":{"mutations":{"nuc":["C5407T","C11461T","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}}]},{"name":"NODE_0001172","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6486213207244873}},"branch_attrs":{"mutations":{"nuc":["C14097T"]}},"children":[{"name":"BQ.1.1.48","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.48"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.48"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.388934135437012}},"branch_attrs":{"mutations":{"nuc":["C22295A"],"S":["H245N"]},"labels":{"aa":"S: H245N","spike_mutations":"H245N"}}},{"name":"BQ.1.1.49","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.49"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.49"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.766948699951172}},"branch_attrs":{"mutations":{"nuc":["A2219G","C24809G"],"S":["H1083D"],"nsp2":["I472V"]},"labels":{"aa":"S: H1083D; nsp2: I472V","spike_mutations":"H1083D"}}},{"name":"BQ.1.1.78","node_attrs":{"div":99,"Nextclade_pango":{"value":"BQ.1.1.78"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.78"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.268287658691406}},"branch_attrs":{"mutations":{"nuc":["G1210T","T2551C","G14400A","C16887T","C19325T"],"nsp14":["P429L"],"nsp2":["M135I"]},"labels":{"aa":"nsp14: P429L; nsp2: M135I"}}}]},{"name":"NODE_0001173","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.46"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C22033A","T25406C"],"ORF3a":["M5T"],"S":["Y144-","F157L"]},"labels":{"aa":"ORF3a: M5T; S: Y144-, F157L","spike_mutations":"Y144-, F157L"}},"children":[{"name":"BQ.1.1.46","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1.46"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.694455146789551}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001174","node_attrs":{"div":96,"Nextclade_pango":{"value":"EN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{"nuc":["G25352T"],"S":["V1264L"]},"labels":{"aa":"S: V1264L","spike_mutations":"V1264L"}},"children":[{"name":"EN.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-26"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.844334602355957}},"branch_attrs":{"mutations":{}}},{"name":"EN.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-06-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.46.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["C2299T","G22021T"],"S":["M153I"]},"labels":{"aa":"S: M153I","spike_mutations":"M153I"}}}]}]},{"name":"internal_1117","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.53"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504777908325195}},"branch_attrs":{"mutations":{"nuc":["A22115G"],"S":["N185D"]},"labels":{"aa":"S: N185D","spike_mutations":"N185D"}},"children":[{"name":"BQ.1.1.53","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.53"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.504777908325195}},"branch_attrs":{"mutations":{}}},{"name":"FM.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"FM.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.918827533721924}},"branch_attrs":{"mutations":{"nuc":["C10576T","T21992-","A21993-","T21994-","G23401T"],"S":["Y144-","Q613H"]},"labels":{"aa":"S: Y144-, Q613H","spike_mutations":"Y144-, Q613H"}}},{"name":"FM.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"FM.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.53.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.83009147644043}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G24398A"],"S":["Y144-","G946R"]},"labels":{"aa":"S: Y144-, G946R","spike_mutations":"Y144-, G946R"}}}]},{"name":"internal_f9e1","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.52"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{"nuc":["C7006T"]}},"children":[{"name":"BQ.1.1.52","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.52"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.13459587097168}},"branch_attrs":{"mutations":{}}},{"name":"EA.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"EA.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.478137493133545}},"branch_attrs":{"mutations":{"nuc":["G28198T"],"ORF8":["C102F"]},"labels":{"aa":"ORF8: C102F"}}},{"name":"EA.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EA.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.34834999999999994"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.880706782961692"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.52.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.922173023223877}},"branch_attrs":{"mutations":{"nuc":["C22971T"],"S":["T470I"]},"labels":{"aa":"S: T470I","spike_mutations":"T470I"}}}]},{"name":"internal_159a","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.18"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{"nuc":["C6541T"]}},"children":[{"name":"BQ.1.1.18","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.18"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4994068145751953}},"branch_attrs":{"mutations":{}}},{"name":"ED.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"ED.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.188085079193115}},"branch_attrs":{"mutations":{"nuc":["G3047T"],"nsp3":["D110Y"]},"labels":{"aa":"nsp3: D110Y"}}},{"name":"ED.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"ED.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.897581100463867}},"branch_attrs":{"mutations":{"nuc":["G24089A"],"S":["D843N"]},"labels":{"aa":"S: D843N","spike_mutations":"D843N"}}},{"name":"ED.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"ED.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.18.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6314659118652344}},"branch_attrs":{"mutations":{"nuc":["T1562A","C25714T","G28079T"],"ORF3a":["L108F"],"nsp2":["C253S"]},"labels":{"aa":"ORF3a: L108F; nsp2: C253S"}}}]},{"name":"NODE_0001178","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.167686462402344}},"branch_attrs":{"mutations":{"nuc":["C18828T"]}},"children":[{"name":"BQ.1.1.54","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.54"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.54"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.553523540496826}},"branch_attrs":{"mutations":{"nuc":["C1627T","G4255A","T22119C","G28904A"],"N":["A211T"],"S":["F186S"]},"labels":{"aa":"N: A211T; S: F186S","spike_mutations":"F186S"}}},{"name":"BQ.1.1.59","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.59"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.59"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.000681400299072}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","C23757T","C29362T"],"S":["Y144-","T732I"]},"labels":{"aa":"S: Y144-, T732I","spike_mutations":"Y144-, T732I"}}},{"name":"NODE_0001179","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.28"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{"nuc":["C16393T","C22314T"],"S":["P251L"],"nsp13":["P53S"]},"labels":{"aa":"S: P251L; nsp13: P53S","spike_mutations":"P251L"}},"children":[{"name":"BQ.1.1.28","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.28"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-04"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.4359612464904785}},"branch_attrs":{"mutations":{}}},{"name":"EH.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EH.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-19"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.28.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.69965124130249}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C","A27388G","A29868G"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]},{"name":"internal_748f","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.32"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.00280237197876}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G22021A"],"S":["Y144-","M153I"]},"labels":{"aa":"S: Y144-, M153I","spike_mutations":"Y144-, M153I"}},"children":[{"name":"BQ.1.1.32","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.32"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-31"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.00280237197876}},"branch_attrs":{"mutations":{}}},{"name":"DT.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"DT.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.66092586517334}},"branch_attrs":{"mutations":{"nuc":["C22088T"],"S":["L176F"]},"labels":{"aa":"S: L176F","spike_mutations":"L176F"}}},{"name":"DT.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"DT.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.224767684936523}},"branch_attrs":{"mutations":{"nuc":["C23202A"],"S":["T547K"]},"labels":{"aa":"S: T547K","spike_mutations":"T547K"}}},{"name":"DT.1","node_attrs":{"div":97,"Nextclade_pango":{"value":"DT.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.7242"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-09"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8884096497350694"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.32.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.3926310539245605}},"branch_attrs":{"mutations":{"nuc":["C7764T","C11986T","T23042C"],"S":["S494P"],"nsp3":["S1682F"]},"labels":{"aa":"S: S494P; nsp3: S1682F","spike_mutations":"S494P"}}}]},{"name":"internal_ORF8F6S","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.117684841156006}},"branch_attrs":{"mutations":{"nuc":["T27910C"],"ORF8":["F6S"]},"labels":{"aa":"ORF8: F6S"}},"children":[{"name":"BQ.1.1.62","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.62"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.62"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.222530364990234}},"branch_attrs":{"mutations":{"nuc":["T17400C","C23423T"],"S":["P621S"]},"labels":{"aa":"S: P621S","spike_mutations":"P621S"}}},{"name":"internal_14424C","node_attrs":{"div":95,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4302690029144287}},"branch_attrs":{"mutations":{"nuc":["A14424C"]}},"children":[{"name":"BQ.1.1.61","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.61"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-11"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.61"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.273682594299316}},"branch_attrs":{"mutations":{"nuc":["C23424A"],"S":["P621H"]},"labels":{"aa":"S: P621H","spike_mutations":"P621H"}}},{"name":"NODE_0001183","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.43"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{"nuc":["C4570T","G23401C","C26292T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}},"children":[{"name":"BQ.1.1.43","node_attrs":{"div":98,"Nextclade_pango":{"value":"BQ.1.1.43"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-28"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.834350109100342}},"branch_attrs":{"mutations":{}}},{"name":"EZ.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EZ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.43.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.460769176483154}},"branch_attrs":{"mutations":{"nuc":["G22302A","A22305C"],"S":["S247N","Y248S"]},"labels":{"aa":"S: S247N, Y248S","spike_mutations":"S247N, Y248S"}}}]}]}]},{"name":"internal_f19c","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.4"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4922916889190674}},"branch_attrs":{"mutations":{"nuc":["T29173C"]}},"children":[{"name":"BQ.1.1.4","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.4922916889190674}},"branch_attrs":{"mutations":{}}},{"name":"EE.1","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.18422269821167}},"branch_attrs":{"mutations":{"nuc":["C29370T"],"N":["T366I"]},"labels":{"aa":"N: T366I"}}},{"name":"EE.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.131554126739502}},"branch_attrs":{"mutations":{"nuc":["G18079A"],"nsp14":["V14I"]},"labels":{"aa":"nsp14: V14I"}}},{"name":"EE.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":59},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.185359477996826}},"branch_attrs":{"mutations":{"nuc":["C22498T"]}}},{"name":"EE.5","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.522237777709961}},"branch_attrs":{"mutations":{"nuc":["A22115T"],"S":["N185Y"]},"labels":{"aa":"S: N185Y","spike_mutations":"N185Y"}}},{"name":"EE.4","node_attrs":{"div":95,"Nextclade_pango":{"value":"EE.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.4.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.840278148651123}},"branch_attrs":{"mutations":{"nuc":["G21718T"],"S":["Q52H"]},"labels":{"aa":"S: Q52H","spike_mutations":"Q52H"}}}]},{"name":"NODE_0001185","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.25513219833374}},"branch_attrs":{"mutations":{"nuc":["C22314T"],"S":["P251L"]},"labels":{"aa":"S: P251L","spike_mutations":"P251L"}},"children":[{"name":"NODE_0001186","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.38"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{"nuc":["T7633C","A24129G"],"S":["N856S"]},"labels":{"aa":"S: N856S","spike_mutations":"N856S"}},"children":[{"name":"BQ.1.1.38","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.38"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.983901023864746}},"branch_attrs":{"mutations":{}}},{"name":"EW.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EW.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6288199999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8585277476746368"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.135380268096924}},"branch_attrs":{"mutations":{"nuc":["T4579A","A22995G"],"S":["K478R"]},"labels":{"aa":"S: K478R","spike_mutations":"K478R"}}},{"name":"EW.2","node_attrs":{"div":99,"Nextclade_pango":{"value":"EW.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.74540901184082}},"branch_attrs":{"mutations":{"nuc":["C19269T","A19703G","C23664T"],"S":["A701V"],"nsp15":["N28S"]},"labels":{"aa":"S: A701V; nsp15: N28S","spike_mutations":"A701V"}}},{"name":"EW.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EW.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.65602"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9455376728168823"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.38.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.699651718139648}},"branch_attrs":{"mutations":{"nuc":["C421T","G22604T"],"S":["A348S"]},"labels":{"aa":"S: A348S","spike_mutations":"A348S"}}}]},{"name":"NODE_0001187","node_attrs":{"div":97,"Nextclade_pango":{"value":"BQ.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.2819671630859375}},"branch_attrs":{"mutations":{"nuc":["A22106G","T23716C","A28834G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}},"children":[{"name":"NODE_0001188","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.39"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{"nuc":["T19293C","G22216T","C25047T"],"S":["Q218H","P1162L"]},"labels":{"aa":"S: Q218H, P1162L","spike_mutations":"Q218H, P1162L"}},"children":[{"name":"BQ.1.1.39","node_attrs":{"div":100,"Nextclade_pango":{"value":"BQ.1.1.39"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-27"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.865018844604492}},"branch_attrs":{"mutations":{}}},{"name":"FQ.1","node_attrs":{"div":102,"Nextclade_pango":{"value":"FQ.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":65},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-04-17"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.39.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.574712753295898}},"branch_attrs":{"mutations":{"nuc":["G1577A","G23401T"],"S":["Q613H"],"nsp2":["V258I"]},"labels":{"aa":"S: Q613H; nsp2: V258I","spike_mutations":"Q613H"}}}]},{"name":"NODE_0001189","node_attrs":{"div":101,"Nextclade_pango":{"value":"BQ.1.1.71"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{"nuc":["G2281A","C8950T","T21992-","A21993-","T21994-","G22898C","T25959C"],"S":["Y144-","G446R"]},"labels":{"aa":"S: Y144-, G446R","spike_mutations":"Y144-, G446R"}},"children":[{"name":"BQ.1.1.71","node_attrs":{"div":101,"Nextclade_pango":{"value":"BQ.1.1.71"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24659999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-03"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.347468852996826}},"branch_attrs":{"mutations":{}}},{"name":"EV.1","node_attrs":{"div":103,"Nextclade_pango":{"value":"EV.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.24659999999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.9021914619017382"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.71.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["A13132G","T22304C"],"S":["Y248H"]},"labels":{"aa":"S: Y248H","spike_mutations":"Y248H"}}}]}]}]},{"name":"NODE_0001190","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.13"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.141762733459473}},"branch_attrs":{"mutations":{"nuc":["T21992-","A21993-","T21994-","G26428T"],"E":["V62F"],"S":["Y144-"]},"labels":{"aa":"E: V62F; S: Y144-","spike_mutations":"Y144-"}},"children":[{"name":"BQ.1.1.13","node_attrs":{"div":94,"Nextclade_pango":{"value":"BQ.1.1.13"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-23"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.141762733459473}},"branch_attrs":{"mutations":{"nuc":["-21992T","-21993A","-21994T"],"S":["-144Y"]},"labels":{"aa":"S: -144Y","spike_mutations":"-144Y"}}},{"name":"EF.2","node_attrs":{"div":95,"Nextclade_pango":{"value":"EF.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.241170883178711}},"branch_attrs":{"mutations":{"nuc":["G13822A"],"nsp12":["V128I"]},"labels":{"aa":"nsp12: V128I"}}},{"name":"EF.3","node_attrs":{"div":95,"Nextclade_pango":{"value":"EF.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-09-10"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.072010517120361}},"branch_attrs":{"mutations":{"nuc":["T23672A"],"S":["S704T"]},"labels":{"aa":"S: S704T","spike_mutations":"S704T"}}},{"name":"NODE_0001191","node_attrs":{"div":96,"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{"nuc":["A1T","C6040T"]}},"children":[{"name":"EF.1","node_attrs":{"div":96,"Nextclade_pango":{"value":"EF.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.180285453796387}},"branch_attrs":{"mutations":{}}},{"name":"internal_bc60","node_attrs":{"div":97,"Nextclade_pango":{"value":"EF.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.138625144958496}},"branch_attrs":{"mutations":{"nuc":["C23086T"]}},"children":[{"name":"EF.1.3","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.220849990844727}},"branch_attrs":{"mutations":{"nuc":["C28770T"],"N":["T166I"]},"labels":{"aa":"N: T166I"}}},{"name":"EF.1.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.328181743621826}},"branch_attrs":{"mutations":{"nuc":["T15492C"]}}},{"name":"internal_e491","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.127105712890625}},"branch_attrs":{"mutations":{"nuc":["T7783C"]}},"children":[{"name":"EF.1.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"EF.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":60},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.127105712890625}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001194","node_attrs":{"div":99,"Nextclade_pango":{"value":"EF.1.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{"nuc":["C22033A"],"S":["F157L"]},"labels":{"aa":"S: F157L","spike_mutations":"F157L"}},"children":[{"name":"EF.1.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"EF.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-02-12"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.656735420227051}},"branch_attrs":{"mutations":{}}},{"name":"EY.1","node_attrs":{"div":100,"Nextclade_pango":{"value":"EY.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":15},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-21"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.13.1.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.543304443359375}},"branch_attrs":{"mutations":{"nuc":["G23401T"],"S":["Q613H"]},"labels":{"aa":"S: Q613H","spike_mutations":"Q613H"}}}]}]}]}]}]},{"name":"NODE_0001195","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.5"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{"nuc":["G11828A","C17676T","C20405T"],"nsp15":["P262L"],"nsp6":["V286I"]},"labels":{"aa":"nsp15: P262L; nsp6: V286I"}},"children":[{"name":"BQ.1.1.5","node_attrs":{"div":96,"Nextclade_pango":{"value":"BQ.1.1.5"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":61},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-10-20"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.8024630546569824}},"branch_attrs":{"mutations":{}}},{"name":"DN.2","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-3.6995503902435303}},"branch_attrs":{"mutations":{"nuc":["A6790G","G20518A"],"nsp15":["D300N"]},"labels":{"aa":"nsp15: D300N"}}},{"name":"NODE_0001196","node_attrs":{"div":97,"Nextclade_pango":{"value":"DN.3"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.508324146270752}},"branch_attrs":{"mutations":{"nuc":["G3338T"],"nsp3":["V207L"]},"labels":{"aa":"nsp3: V207L"}},"children":[{"name":"DN.3","node_attrs":{"div":97,"Nextclade_pango":{"value":"DN.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.508324146270752}},"branch_attrs":{"mutations":{}}},{"name":"DN.3.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.3.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-05-07"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.3.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-7.333120346069336}},"branch_attrs":{"mutations":{"nuc":["A22106G"],"S":["K182E"]},"labels":{"aa":"S: K182E","spike_mutations":"K182E"}}}]},{"name":"NODE_0001197","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{"nuc":["A22003T","C26010T"],"S":["K147N"]},"labels":{"aa":"S: K147N","spike_mutations":"K147N"}},"children":[{"name":"DN.1","node_attrs":{"div":98,"Nextclade_pango":{"value":"DN.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":62},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-22"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.858296871185303}},"branch_attrs":{"mutations":{}}},{"name":"NODE_0001198","node_attrs":{"div":99,"Nextclade_pango":{"value":"DN.1.1"},"clade_who":{"value":"Omicron"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{"nuc":["C6740T"],"nsp3":["R1341W"]},"labels":{"aa":"nsp3: R1341W"}},"children":[{"name":"DN.1.1.1","node_attrs":{"div":104,"Nextclade_pango":{"value":"DN.1.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"2.05606"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":66},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8990816968865659"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-10}},"branch_attrs":{"mutations":{"nuc":["G2426A","A8520G","C8905T","A22920T","T29446C"],"S":["Y453F"],"nsp2":["V541I"],"nsp3":["N1934S"]},"labels":{"aa":"S: Y453F; nsp2: V541I; nsp3: N1934S","spike_mutations":"Y453F"}}},{"name":"DN.1.1","node_attrs":{"div":99,"Nextclade_pango":{"value":"DN.1.1"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":63},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2022-12-25"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-4.668242931365967}},"branch_attrs":{"mutations":{}}},{"name":"DN.1.1.3","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.3"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.77543"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8399353043011233"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.3"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.097591400146484}},"branch_attrs":{"mutations":{"nuc":["C23673T","C25515T"],"S":["S704L"]},"labels":{"aa":"S: S704L","spike_mutations":"S704L"}}},{"name":"DN.1.1.2","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.2"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.5626099999999999"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-01-30"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8771384492554943"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.2"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-6.176772594451904}},"branch_attrs":{"mutations":{"nuc":["C703T","C22998T"],"S":["P479L"]},"labels":{"aa":"S: P479L","spike_mutations":"P479L"}}},{"name":"DN.1.1.4","node_attrs":{"div":101,"Nextclade_pango":{"value":"DN.1.1.4"},"qc.stopCodons.totalStopCodons":{"value":0},"ace2_binding":{"value":"0.6722600000000001"},"designation_recency":{"value":">8 weeks"},"clade_who":{"value":"Omicron"},"totalAminoacidSubstitutions":{"value":64},"totalAminoacidDeletions":{"value":14},"qc.overallScore":{"value":0.0},"designation_date":{"value":"2023-03-24"},"qc.frameShifts.totalFrameShifts":{"value":0},"immune_escape":{"value":"0.8744814686582322"},"clade_display":{"value":"22E (BQ.1)"},"partiallyAliased":{"value":"BA.5.3.1.1.1.1.1.1.5.1.1.4"},"clade_nextstrain":{"value":"22E"},"clade_membership":{"value":"22E"},"placement_prior":{"value":-5.398621559143066}},"branch_attrs":{"mutations":{"nuc":["T14046C","A23004G"],"S":["N481S"]},"labels":{"aa":"S: N481S","spike_mutations":"N481S"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]},"root_sequence":{"E":"MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV*","M":"MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ*","N":"MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA*","ORF10":"MGYINVFAFPFTIYSLLLCRMNSRNYIAQVDVVNFNLT*","ORF3a":"MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL*","ORF6":"MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID*","ORF7a":"MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE*","ORF7b":"MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETCHA*","ORF8":"MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI*","ORF9b":"MDPKISEMHPALRLVDPQIQLAVTRMENAVGRDQNNVGPKVYPIILRLGSPLSLNMARKTLNSLEDKAFQLTPIAVQMTKLATTEELPDEFVVVTVK*","S":"MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*","nsp1":"MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRKVLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG","nsp10":"AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQ","nsp11":"SADAQSFLNGFAV","nsp12":"SADAQSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ","nsp13":"AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQ","nsp14":"AENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTFTRLQ","nsp15":"SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ","nsp16":"SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN","nsp2":"AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGG","nsp3":"APTKVTFGDDTVIEVQGYKSVNITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPSVEQRKQDDKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKGG","nsp4":"KIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIVAIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLTFYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHLAKALNDFSNSGSDVLYQPPQTSITSAVLQ","nsp5":"SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ","nsp6":"SAVKRTIKGTHHWLLLTILTSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQ","nsp7":"SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQ","nsp8":"AIASEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRANSAVKLQ","nsp9":"NNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ","nuc":"ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACCACTGGGCATTGATTTAGATGAGTGGAGTATGGCTACATACTACTTATTTGATGAGTCTGGTGAGTTTAAATTGGCTTCACATATGTATTGTTCTTTCTACCCTCCAGATGAGGATGAAGAAGAAGGTGATTGTGAAGAAGAAGAGTTTGAGCCATCAACTCAATATGAGTATGGTACTGAAGATGATTACCAAGGTAAACCTTTGGAATTTGGTGCCACTTCTGCTGCTCTTCAACCTGAAGAAGAGCAAGAAGAAGATTGGTTAGATGATGATAGTCAACAAACTGTTGGTCAACAAGACGGCAGTGAGGACAATCAGACAACTACTATTCAAACAATTGTTGAGGTTCAACCTCAATTAGAGATGGAACTTACACCAGTTGTTCAGACTATTGAAGTGAATAGTTTTAGTGGTTATTTAAAACTTACTGACAATGTATACATTAAAAATGCAGACATTGTGGAAGAAGCTAAAAAGGTAAAACCAACAGTGGTTGTTAATGCAGCCAATGTTTACCTTAAACATGGAGGAGGTGTTGCAGGAGCCTTAAATAAGGCTACTAACAATGCCATGCAAGTTGAATCTGATGATTACATAGCTACTAATGGACCACTTAAAGTGGGTGGTAGTTGTGTTTTAAGCGGACACAATCTTGCTAAACACTGTCTTCATGTTGTCGGCCCAAATGTTAACAAAGGTGAAGACATTCAACTTCTTAAGAGTGCTTATGAAAATTTTAATCAGCACGAAGTTCTACTTGCACCATTATTATCAGCTGGTATTTTTGGTGCTGACCCTATACATTCTTTAAGAGTTTGTGTAGATACTGTTCGCACAAATGTCTACTTAGCTGTCTTTGATAAAAATCTCTATGACAAACTTGTTTCAAGCTTTTTGGAAATGAAGAGTGAAAAGCAAGTTGAACAAAAGATCGCTGAGATTCCTAAAGAGGAAGTTAAGCCATTTATAACTGAAAGTAAACCTTCAGTTGAACAGAGAAAACAAGATGATAAGAAAATCAAAGCTTGTGTTGAAGAAGTTACAACAACTCTGGAAGAAACTAAGTTCCTCACAGAAAACTTGTTACTTTATATTGACATTAATGGCAATCTTCATCCAGATTCTGCCACTCTTGTTAGTGACATTGACATCACTTTCTTAAAGAAAGATGCTCCATATATAGTGGGTGATGTTGTTCAAGAGGGTGTTTTAACTGCTGTGGTTATACCTACTAAAAAGGCTGGTGGCACTACTGAAATGCTAGCGAAAGCTTTGAGAAAAGTGCCAACAGACAATTATATAACCACTTACCCGGGTCAGGGTTTAAATGGTTACACTGTAGAGGAGGCAAAGACAGTGCTTAAAAAGTGTAAAAGTGCCTTTTACATTCTACCATCTATTATCTCTAATGAGAAGCAAGAAATTCTTGGAACTGTTTCTTGGAATTTGCGAGAAATGCTTGCACATGCAGAAGAAACACGCAAATTAATGCCTGTCTGTGTGGAAACTAAAGCCATAGTTTCAACTATACAGCGTAAATATAAGGGTATTAAAATACAAGAGGGTGTGGTTGATTATGGTGCTAGATTTTACTTTTACACCAGTAAAACAACTGTAGCGTCACTTATCAACACACTTAACGATCTAAATGAAACTCTTGTTACAATGCCACTTGGCTATGTAACACATGGCTTAAATTTGGAAGAAGCTGCTCGGTATATGAGATCTCTCAAAGTGCCAGCTACAGTTTCTGTTTCTTCACCTGATGCTGTTACAGCGTATAATGGTTATCTTACTTCTTCTTCTAAAACACCTGAAGAACATTTTATTGAAACCATCTCACTTGCTGGTTCCTATAAAGATTGGTCCTATTCTGGACAATCTACACAACTAGGTATAGAATTTCTTAAGAGAGGTGATAAAAGTGTATATTACACTAGTAATCCTACCACATTCCACCTAGATGGTGAAGTTATCACCTTTGACAATCTTAAGACACTTCTTTCTTTGAGAGAAGTGAGGACTATTAAGGTGTTTACAACAGTAGACAACATTAACCTCCACACGCAAGTTGTGGACATGTCAATGACATATGGACAACAGTTTGGTCCAACTTATTTGGATGGAGCTGATGTTACTAAAATAAAACCTCATAATTCACATGAAGGTAAAACATTTTATGTTTTACCTAATGATGACACTCTACGTGTTGAGGCTTTTGAGTACTACCACACAACTGATCCTAGTTTTCTGGGTAGGTACATGTCAGCATTAAATCACACTAAAAAGTGGAAATACCCACAAGTTAATGGTTTAACTTCTATTAAATGGGCAGATAACAACTGTTATCTTGCCACTGCATTGTTAACACTCCAACAAATAGAGTTGAAGTTTAATCCACCTGCTCTACAAGATGCTTATTACAGAGCAAGGGCTGGTGAAGCTGCTAACTTTTGTGCACTTATCTTAGCCTACTGTAATAAGACAGTAGGTGAGTTAGGTGATGTTAGAGAAACAATGAGTTACTTGTTTCAACATGCCAATTTAGATTCTTGCAAAAGAGTCTTGAACGTGGTGTGTAAAACTTGTGGACAACAGCAGACAACCCTTAAGGGTGTAGAAGCTGTTATGTACATGGGCACACTTTCTTATGAACAATTTAAGAAAGGTGTTCAGATACCTTGTACGTGTGGTAAACAAGCTACAAAATATCTAGTACAACAGGAGTCACCTTTTGTTATGATGTCAGCACCACCTGCTCAGTATGAACTTAAGCATGGTACATTTACTTGTGCTAGTGAGTACACTGGTAATTACCAGTGTGGTCACTATAAACATATAACTTCTAAAGAAACTTTGTATTGCATAGACGGTGCTTTACTTACAAAGTCCTCAGAATACAAAGGTCCTATTACGGATGTTTTCTACAAAGAAAACAGTTACACAACAACCATAAAACCAGTTACTTATAAATTGGATGGTGTTGTTTGTACAGAAATTGACCCTAAGTTGGACAATTATTATAAGAAAGACAATTCTTATTTCACAGAGCAACCAATTGATCTTGTACCAAACCAACCATATCCAAACGCAAGCTTCGATAATTTTAAGTTTGTATGTGATAATATCAAATTTGCTGATGATTTAAACCAGTTAACTGGTTATAAGAAACCTGCTTCAAGAGAGCTTAAAGTTACATTTTTCCCTGACTTAAATGGTGATGTGGTGGCTATTGATTATAAACACTACACACCCTCTTTTAAGAAAGGAGCTAAATTGTTACATAAACCTATTGTTTGGCATGTTAACAATGCAACTAATAAAGCCACGTATAAACCAAATACCTGGTGTATACGTTGTCTTTGGAGCACAAAACCAGTTGAAACATCAAATTCGTTTGATGTACTGAAGTCAGAGGACGCGCAGGGAATGGATAATCTTGCCTGCGAAGATCTAAAACCAGTCTCTGAAGAAGTAGTGGAAAATCCTACCATACAGAAAGACGTTCTTGAGTGTAATGTGAAAACTACCGAAGTTGTAGGAGACATTATACTTAAACCAGCAAATAATAGTTTAAAAATTACAGAAGAGGTTGGCCACACAGATCTAATGGCTGCTTATGTAGACAATTCTAGTCTTACTATTAAGAAACCTAATGAATTATCTAGAGTATTAGGTTTGAAAACCCTTGCTACTCATGGTTTAGCTGCTGTTAATAGTGTCCCTTGGGATACTATAGCTAATTATGCTAAGCCTTTTCTTAACAAAGTTGTTAGTACAACTACTAACATAGTTACACGGTGTTTAAACCGTGTTTGTACTAATTATATGCCTTATTTCTTTACTTTATTGCTACAATTGTGTACTTTTACTAGAAGTACAAATTCTAGAATTAAAGCATCTATGCCGACTACTATAGCAAAGAATACTGTTAAGAGTGTCGGTAAATTTTGTCTAGAGGCTTCATTTAATTATTTGAAGTCACCTAATTTTTCTAAACTGATAAATATTATAATTTGGTTTTTACTATTAAGTGTTTGCCTAGGTTCTTTAATCTACTCAACCGCTGCTTTAGGTGTTTTAATGTCTAATTTAGGCATGCCTTCTTACTGTACTGGTTACAGAGAAGGCTATTTGAACTCTACTAATGTCACTATTGCAACCTACTGTACTGGTTCTATACCTTGTAGTGTTTGTCTTAGTGGTTTAGATTCTTTAGACACCTATCCTTCTTTAGAAACTATACAAATTACCATTTCATCTTTTAAATGGGATTTAACTGCTTTTGGCTTAGTTGCAGAGTGGTTTTTGGCATATATTCTTTTCACTAGGTTTTTCTATGTACTTGGATTGGCTGCAATCATGCAATTGTTTTTCAGCTATTTTGCAGTACATTTTATTAGTAATTCTTGGCTTATGTGGTTAATAATTAATCTTGTACAAATGGCCCCGATTTCAGCTATGGTTAGAATGTACATCTTCTTTGCATCATTTTATTATGTATGGAAAAGTTATGTGCATGTTGTAGACGGTTGTAATTCATCAACTTGTATGATGTGTTACAAACGTAATAGAGCAACAAGAGTCGAATGTACAACTATTGTTAATGGTGTTAGAAGGTCCTTTTATGTCTATGCTAATGGAGGTAAAGGCTTTTGCAAACTACACAATTGGAATTGTGTTAATTGTGATACATTCTGTGCTGGTAGTACATTTATTAGTGATGAAGTTGCGAGAGACTTGTCACTACAGTTTAAAAGACCAATAAATCCTACTGACCAGTCTTCTTACATCGTTGATAGTGTTACAGTGAAGAATGGTTCCATCCATCTTTACTTTGATAAAGCTGGTCAAAAGACTTATGAAAGACATTCTCTCTCTCATTTTGTTAACTTAGACAACCTGAGAGCTAATAACACTAAAGGTTCATTGCCTATTAATGTTATAGTTTTTGATGGTAAATCAAAATGTGAAGAATCATCTGCAAAATCAGCGTCTGTTTACTACAGTCAGCTTATGTGTCAACCTATACTGTTACTAGATCAGGCATTAGTGTCTGATGTTGGTGATAGTGCGGAAGTTGCAGTTAAAATGTTTGATGCTTACGTTAATACGTTTTCATCAACTTTTAACGTACCAATGGAAAAACTCAAAACACTAGTTGCAACTGCAGAAGCTGAACTTGCAAAGAATGTGTCCTTAGACAATGTCTTATCTACTTTTATTTCAGCAGCTCGGCAAGGGTTTGTTGATTCAGATGTAGAAACTAAAGATGTTGTTGAATGTCTTAAATTGTCACATCAATCTGACATAGAAGTTACTGGCGATAGTTGTAATAACTATATGCTCACCTATAACAAAGTTGAAAACATGACACCCCGTGACCTTGGTGCTTGTATTGACTGTAGTGCGCGTCATATTAATGCGCAGGTAGCAAAAAGTCACAACATTGCTTTGATATGGAACGTTAAAGATTTCATGTCATTGTCTGAACAACTACGAAAACAAATACGTAGTGCTGCTAAAAAGAATAACTTACCTTTTAAGTTGACATGTGCAACTACTAGACAAGTTGTTAATGTTGTAACAACAAAGATAGCACTTAAGGGTGGTAAAATTGTTAATAATTGGTTGAAGCAGTTAATTAAAGTTACACTTGTGTTCCTTTTTGTTGCTGCTATTTTCTATTTAATAACACCTGTTCATGTCATGTCTAAACATACTGACTTTTCAAGTGAAATCATAGGATACAAGGCTATTGATGGTGGTGTCACTCGTGACATAGCATCTACAGATACTTGTTTTGCTAACAAACATGCTGATTTTGACACATGGTTTAGCCAGCGTGGTGGTAGTTATACTAATGACAAAGCTTGCCCATTGATTGCTGCAGTCATAACAAGAGAAGTGGGTTTTGTCGTGCCTGGTTTGCCTGGCACGATATTACGCACAACTAATGGTGACTTTTTGCATTTCTTACCTAGAGTTTTTAGTGCAGTTGGTAACATCTGTTACACACCATCAAAACTTATAGAGTACACTGACTTTGCAACATCAGCTTGTGTTTTGGCTGCTGAATGTACAATTTTTAAAGATGCTTCTGGTAAGCCAGTACCATATTGTTATGATACCAATGTACTAGAAGGTTCTGTTGCTTATGAAAGTTTACGCCCTGACACACGTTATGTGCTCATGGATGGCTCTATTATTCAATTTCCTAACACCTACCTTGAAGGTTCTGTTAGAGTGGTAACAACTTTTGATTCTGAGTACTGTAGGCACGGCACTTGTGAAAGATCAGAAGCTGGTGTTTGTGTATCTACTAGTGGTAGATGGGTACTTAACAATGATTATTACAGATCTTTACCAGGAGTTTTCTGTGGTGTAGATGCTGTAAATTTACTTACTAATATGTTTACACCACTAATTCAACCTATTGGTGCTTTGGACATATCAGCATCTATAGTAGCTGGTGGTATTGTAGCTATCGTAGTAACATGCCTTGCCTACTATTTTATGAGGTTTAGAAGAGCTTTTGGTGAATACAGTCATGTAGTTGCCTTTAATACTTTACTATTCCTTATGTCATTCACTGTACTCTGTTTAACACCAGTTTACTCATTCTTACCTGGTGTTTATTCTGTTATTTACTTGTACTTGACATTTTATCTTACTAATGATGTTTCTTTTTTAGCACATATTCAGTGGATGGTTATGTTCACACCTTTAGTACCTTTCTGGATAACAATTGCTTATATCATTTGTATTTCCACAAAGCATTTCTATTGGTTCTTTAGTAATTACCTAAAGAGACGTGTAGTCTTTAATGGTGTTTCCTTTAGTACTTTTGAAGAAGCTGCGCTGTGCACCTTTTTGTTAAATAAAGAAATGTATCTAAAGTTGCGTAGTGATGTGCTATTACCTCTTACGCAATATAATAGATACTTAGCTCTTTATAATAAGTACAAGTATTTTAGTGGAGCAATGGATACAACTAGCTACAGAGAAGCTGCTTGTTGTCATCTCGCAAAGGCTCTCAATGACTTCAGTAACTCAGGTTCTGATGTTCTTTACCAACCACCACAAACCTCTATCACCTCAGCTGTTTTGCAGAGTGGTTTTAGAAAAATGGCATTCCCATCTGGTAAAGTTGAGGGTTGTATGGTACAAGTAACTTGTGGTACAACTACACTTAACGGTCTTTGGCTTGATGACGTAGTTTACTGTCCAAGACATGTGATCTGCACCTCTGAAGACATGCTTAACCCTAATTATGAAGATTTACTCATTCGTAAGTCTAATCATAATTTCTTGGTACAGGCTGGTAATGTTCAACTCAGGGTTATTGGACATTCTATGCAAAATTGTGTACTTAAGCTTAAGGTTGATACAGCCAATCCTAAGACACCTAAGTATAAGTTTGTTCGCATTCAACCAGGACAGACTTTTTCAGTGTTAGCTTGTTACAATGGTTCACCATCTGGTGTTTACCAATGTGCTATGAGGCCCAATTTCACTATTAAGGGTTCATTCCTTAATGGTTCATGTGGTAGTGTTGGTTTTAACATAGATTATGACTGTGTCTCTTTTTGTTACATGCACCATATGGAATTACCAACTGGAGTTCATGCTGGCACAGACTTAGAAGGTAACTTTTATGGACCTTTTGTTGACAGGCAAACAGCACAAGCAGCTGGTACGGACACAACTATTACAGTTAATGTTTTAGCTTGGTTGTACGCTGCTGTTATAAATGGAGACAGGTGGTTTCTCAATCGATTTACCACAACTCTTAATGACTTTAACCTTGTGGCTATGAAGTACAATTATGAACCTCTAACACAAGACCATGTTGACATACTAGGACCTCTTTCTGCTCAAACTGGAATTGCCGTTTTAGATATGTGTGCTTCATTAAAAGAATTACTGCAAAATGGTATGAATGGACGTACCATATTGGGTAGTGCTTTATTAGAAGATGAATTTACACCTTTTGATGTTGTTAGACAATGCTCAGGTGTTACTTTCCAAAGTGCAGTGAAAAGAACAATCAAGGGTACACACCACTGGTTGTTACTCACAATTTTGACTTCACTTTTAGTTTTAGTCCAGAGTACTCAATGGTCTTTGTTCTTTTTTTTGTATGAAAATGCCTTTTTACCTTTTGCTATGGGTATTATTGCTATGTCTGCTTTTGCAATGATGTTTGTCAAACATAAGCATGCATTTCTCTGTTTGTTTTTGTTACCTTCTCTTGCCACTGTAGCTTATTTTAATATGGTCTATATGCCTGCTAGTTGGGTGATGCGTATTATGACATGGTTGGATATGGTTGATACTAGTTTGTCTGGTTTTAAGCTAAAAGACTGTGTTATGTATGCATCAGCTGTAGTGTTACTAATCCTTATGACAGCAAGAACTGTGTATGATGATGGTGCTAGGAGAGTGTGGACACTTATGAATGTCTTGACACTCGTTTATAAAGTTTATTATGGTAATGCTTTAGATCAAGCCATTTCCATGTGGGCTCTTATAATCTCTGTTACTTCTAACTACTCAGGTGTAGTTACAACTGTCATGTTTTTGGCCAGAGGTATTGTTTTTATGTGTGTTGAGTATTGCCCTATTTTCTTCATAACTGGTAATACACTTCAGTGTATAATGCTAGTTTATTGTTTCTTAGGCTATTTTTGTACTTGTTACTTTGGCCTCTTTTGTTTACTCAACCGCTACTTTAGACTGACTCTTGGTGTTTATGATTACTTAGTTTCTACACAGGAGTTTAGATATATGAATTCACAGGGACTACTCCCACCCAAGAATAGCATAGATGCCTTCAAACTCAACATTAAATTGTTGGGTGTTGGTGGCAAACCTTGTATCAAAGTAGCCACTGTACAGTCTAAAATGTCAGATGTAAAGTGCACATCAGTAGTCTTACTCTCAGTTTTGCAACAACTCAGAGTAGAATCATCATCTAAATTGTGGGCTCAATGTGTCCAGTTACACAATGACATTCTCTTAGCTAAAGATACTACTGAAGCCTTTGAAAAAATGGTTTCACTACTTTCTGTTTTGCTTTCCATGCAGGGTGCTGTAGACATAAACAAGCTTTGTGAAGAAATGCTGGACAACAGGGCAACCTTACAAGCTATAGCCTCAGAGTTTAGTTCCCTTCCATCATATGCAGCTTTTGCTACTGCTCAAGAAGCTTATGAGCAGGCTGTTGCTAATGGTGATTCTGAAGTTGTTCTTAAAAAGTTGAAGAAGTCTTTGAATGTGGCTAAATCTGAATTTGACCGTGATGCAGCCATGCAACGTAAGTTGGAAAAGATGGCTGATCAAGCTATGACCCAAATGTATAAACAGGCTAGATCTGAGGACAAGAGGGCAAAAGTTACTAGTGCTATGCAGACAATGCTTTTCACTATGCTTAGAAAGTTGGATAATGATGCACTCAACAACATTATCAACAATGCAAGAGATGGTTGTGTTCCCTTGAACATAATACCTCTTACAACAGCAGCCAAACTAATGGTTGTCATACCAGACTATAACACATATAAAAATACGTGTGATGGTACAACATTTACTTATGCATCAGCATTGTGGGAAATCCAACAGGTTGTAGATGCAGATAGTAAAATTGTTCAACTTAGTGAAATTAGTATGGACAATTCACCTAATTTAGCATGGCCTCTTATTGTAACAGCTTTAAGGGCCAATTCTGCTGTCAAATTACAGAATAATGAGCTTAGTCCTGTTGCACTACGACAGATGTCTTGTGCTGCCGGTACTACACAAACTGCTTGCACTGATGACAATGCGTTAGCTTACTACAACACAACAAAGGGAGGTAGGTTTGTACTTGCACTGTTATCCGATTTACAGGATTTGAAATGGGCTAGATTCCCTAAGAGTGATGGAACTGGTACTATCTATACAGAACTGGAACCACCTTGTAGGTTTGTTACAGACACACCTAAAGGTCCTAAAGTGAAGTATTTATACTTTATTAAAGGATTAAACAACCTAAATAGAGGTATGGTACTTGGTAGTTTAGCTGCCACAGTACGTCTACAAGCTGGTAATGCAACAGAAGTGCCTGCCAATTCAACTGTATTATCTTTCTGTGCTTTTGCTGTAGATGCTGCTAAAGCTTACAAAGATTATCTAGCTAGTGGGGGACAACCAATCACTAATTGTGTTAAGATGTTGTGTACACACACTGGTACTGGTCAGGCAATAACAGTTACACCGGAAGCCAATATGGATCAAGAATCCTTTGGTGGTGCATCGTGTTGTCTGTACTGCCGTTGCCACATAGATCATCCAAATCCTAAAGGATTTTGTGACTTAAAAGGTAAGTATGTACAAATACCTACAACTTGTGCTAATGACCCTGTGGGTTTTACACTTAAAAACACAGTCTGTACCGTCTGCGGTATGTGGAAAGGTTATGGCTGTAGTTGTGATCAACTCCGCGAACCCATGCTTCAGTCAGCTGATGCACAATCGTTTTTAAACGGGTTTGCGGTGTAAGTGCAGCCCGTCTTACACCGTGCGGCACAGGCACTAGTACTGATGTCGTATACAGGGCTTTTGACATCTACAATGATAAAGTAGCTGGTTTTGCTAAATTCCTAAAAACTAATTGTTGTCGCTTCCAAGAAAAGGACGAAGATGACAATTTAATTGATTCTTACTTTGTAGTTAAGAGACACACTTTCTCTAACTACCAACATGAAGAAACAATTTATAATTTACTTAAGGATTGTCCAGCTGTTGCTAAACATGACTTCTTTAAGTTTAGAATAGACGGTGACATGGTACCACATATATCACGTCAACGTCTTACTAAATACACAATGGCAGACCTCGTCTATGCTTTAAGGCATTTTGATGAAGGTAATTGTGACACATTAAAAGAAATACTTGTCACATACAATTGTTGTGATGATGATTATTTCAATAAAAAGGACTGGTATGATTTTGTAGAAAACCCAGATATATTACGCGTATACGCCAACTTAGGTGAACGTGTACGCCAAGCTTTGTTAAAAACAGTACAATTCTGTGATGCCATGCGAAATGCTGGTATTGTTGGTGTACTGACATTAGATAATCAAGATCTCAATGGTAACTGGTATGATTTCGGTGATTTCATACAAACCACGCCAGGTAGTGGAGTTCCTGTTGTAGATTCTTATTATTCATTGTTAATGCCTATATTAACCTTGACCAGGGCTTTAACTGCAGAGTCACATGTTGACACTGACTTAACAAAGCCTTACATTAAGTGGGATTTGTTAAAATATGACTTCACGGAAGAGAGGTTAAAACTCTTTGACCGTTATTTTAAATATTGGGATCAGACATACCACCCAAATTGTGTTAACTGTTTGGATGACAGATGCATTCTGCATTGTGCAAACTTTAATGTTTTATTCTCTACAGTGTTCCCACCTACAAGTTTTGGACCACTAGTGAGAAAAATATTTGTTGATGGTGTTCCATTTGTAGTTTCAACTGGATACCACTTCAGAGAGCTAGGTGTTGTACATAATCAGGATGTAAACTTACATAGCTCTAGACTTAGTTTTAAGGAATTACTTGTGTATGCTGCTGACCCTGCTATGCACGCTGCTTCTGGTAATCTATTACTAGATAAACGCACTACGTGCTTTTCAGTAGCTGCACTTACTAACAATGTTGCTTTTCAAACTGTCAAACCCGGTAATTTTAACAAAGACTTCTATGACTTTGCTGTGTCTAAGGGTTTCTTTAAGGAAGGAAGTTCTGTTGAATTAAAACACTTCTTCTTTGCTCAGGATGGTAATGCTGCTATCAGCGATTATGACTACTATCGTTATAATCTACCAACAATGTGTGATATCAGACAACTACTATTTGTAGTTGAAGTTGTTGATAAGTACTTTGATTGTTACGATGGTGGCTGTATTAATGCTAACCAAGTCATCGTCAACAACCTAGACAAATCAGCTGGTTTTCCATTTAATAAATGGGGTAAGGCTAGACTTTATTATGATTCAATGAGTTATGAGGATCAAGATGCACTTTTCGCATATACAAAACGTAATGTCATCCCTACTATAACTCAAATGAATCTTAAGTATGCCATTAGTGCAAAGAATAGAGCTCGCACCGTAGCTGGTGTCTCTATCTGTAGTACTATGACCAATAGACAGTTTCATCAAAAATTATTGAAATCAATAGCCGCCACTAGAGGAGCTACTGTAGTAATTGGAACAAGCAAATTCTATGGTGGTTGGCACAACATGTTAAAAACTGTTTATAGTGATGTAGAAAACCCTCACCTTATGGGTTGGGATTATCCTAAATGTGATAGAGCCATGCCTAACATGCTTAGAATTATGGCCTCACTTGTTCTTGCTCGCAAACATACAACGTGTTGTAGCTTGTCACACCGTTTCTATAGATTAGCTAATGAGTGTGCTCAAGTATTGAGTGAAATGGTCATGTGTGGCGGTTCACTATATGTTAAACCAGGTGGAACCTCATCAGGAGATGCCACAACTGCTTATGCTAATAGTGTTTTTAACATTTGTCAAGCTGTCACGGCCAATGTTAATGCACTTTTATCTACTGATGGTAACAAAATTGCCGATAAGTATGTCCGCAATTTACAACACAGACTTTATGAGTGTCTCTATAGAAATAGAGATGTTGACACAGACTTTGTGAATGAGTTTTACGCATATTTGCGTAAACATTTCTCAATGATGATACTCTCTGACGATGCTGTTGTGTGTTTCAATAGCACTTATGCATCTCAAGGTCTAGTGGCTAGCATAAAGAACTTTAAGTCAGTTCTTTATTATCAAAACAATGTTTTTATGTCTGAAGCAAAATGTTGGACTGAGACTGACCTTACTAAAGGACCTCATGAATTTTGCTCTCAACATACAATGCTAGTTAAACAGGGTGATGATTATGTGTACCTTCCTTACCCAGATCCATCAAGAATCCTAGGGGCCGGCTGTTTTGTAGATGATATCGTAAAAACAGATGGTACACTTATGATTGAACGGTTCGTGTCTTTAGCTATAGATGCTTACCCACTTACTAAACATCCTAATCAGGAGTATGCTGATGTCTTTCATTTGTACTTACAATACATAAGAAAGCTACATGATGAGTTAACAGGACACATGTTAGACATGTATTCTGTTATGCTTACTAATGATAACACTTCAAGGTATTGGGAACCTGAGTTTTATGAGGCTATGTACACACCGCATACAGTCTTACAGGCTGTTGGGGCTTGTGTTCTTTGCAATTCACAGACTTCATTAAGATGTGGTGCTTGCATACGTAGACCATTCTTATGTTGTAAATGCTGTTACGACCATGTCATATCAACATCACATAAATTAGTCTTGTCTGTTAATCCGTATGTTTGCAATGCTCCAGGTTGTGATGTCACAGATGTGACTCAACTTTACTTAGGAGGTATGAGCTATTATTGTAAATCACATAAACCACCCATTAGTTTTCCATTGTGTGCTAATGGACAAGTTTTTGGTTTATATAAAAATACATGTGTTGGTAGCGATAATGTTACTGACTTTAATGCAATTGCAACATGTGACTGGACAAATGCTGGTGATTACATTTTAGCTAACACCTGTACTGAAAGACTCAAGCTTTTTGCAGCAGAAACGCTCAAAGCTACTGAGGAGACATTTAAACTGTCTTATGGTATTGCTACTGTACGTGAAGTGCTGTCTGACAGAGAATTACATCTTTCATGGGAAGTTGGTAAACCTAGACCACCACTTAACCGAAATTATGTCTTTACTGGTTATCGTGTAACTAAAAACAGTAAAGTACAAATAGGAGAGTACACCTTTGAAAAAGGTGACTATGGTGATGCTGTTGTTTACCGAGGTACAACAACTTACAAATTAAATGTTGGTGATTATTTTGTGCTGACATCACATACAGTAATGCCATTAAGTGCACCTACACTAGTGCCACAAGAGCACTATGTTAGAATTACTGGCTTATACCCAACACTCAATATCTCAGATGAGTTTTCTAGCAATGTTGCAAATTATCAAAAGGTTGGTATGCAAAAGTATTCTACACTCCAGGGACCACCTGGTACTGGTAAGAGTCATTTTGCTATTGGCCTAGCTCTCTACTACCCTTCTGCTCGCATAGTGTATACAGCTTGCTCTCATGCCGCTGTTGATGCACTATGTGAGAAGGCATTAAAATATTTGCCTATAGATAAATGTAGTAGAATTATACCTGCACGTGCTCGTGTAGAGTGTTTTGATAAATTCAAAGTGAATTCAACATTAGAACAGTATGTCTTTTGTACTGTAAATGCATTGCCTGAGACGACAGCAGATATAGTTGTCTTTGATGAAATTTCAATGGCCACAAATTATGATTTGAGTGTTGTCAATGCCAGATTACGTGCTAAGCACTATGTGTACATTGGCGACCCTGCTCAATTACCTGCACCACGCACATTGCTAACTAAGGGCACACTAGAACCAGAATATTTCAATTCAGTGTGTAGACTTATGAAAACTATAGGTCCAGACATGTTCCTCGGAACTTGTCGGCGTTGTCCTGCTGAAATTGTTGACACTGTGAGTGCTTTGGTTTATGATAATAAGCTTAAAGCACATAAAGACAAATCAGCTCAATGCTTTAAAATGTTTTATAAGGGTGTTATCACGCATGATGTTTCATCTGCAATTAACAGGCCACAAATAGGCGTGGTAAGAGAATTCCTTACACGTAACCCTGCTTGGAGAAAAGCTGTCTTTATTTCACCTTATAATTCACAGAATGCTGTAGCCTCAAAGATTTTGGGACTACCAACTCAAACTGTTGATTCATCACAGGGCTCAGAATATGACTATGTCATATTCACTCAAACCACTGAAACAGCTCACTCTTGTAATGTAAACAGATTTAATGTTGCTATTACCAGAGCAAAAGTAGGCATACTTTGCATAATGTCTGATAGAGACCTTTATGACAAGTTGCAATTTACAAGTCTTGAAATTCCACGTAGGAATGTGGCAACTTTACAAGCTGAAAATGTAACAGGACTCTTTAAAGATTGTAGTAAGGTAATCACTGGGTTACATCCTACACAGGCACCTACACACCTCAGTGTTGACACTAAATTCAAAACTGAAGGTTTATGTGTTGACATACCTGGCATACCTAAGGACATGACCTATAGAAGACTCATCTCTATGATGGGTTTTAAAATGAATTATCAAGTTAATGGTTACCCTAACATGTTTATCACCCGCGAAGAAGCTATAAGACATGTACGTGCATGGATTGGCTTCGATGTCGAGGGGTGTCATGCTACTAGAGAAGCTGTTGGTACCAATTTACCTTTACAGCTAGGTTTTTCTACAGGTGTTAACCTAGTTGCTGTACCTACAGGTTATGTTGATACACCTAATAATACAGATTTTTCCAGAGTTAGTGCTAAACCACCGCCTGGAGATCAATTTAAACACCTCATACCACTTATGTACAAAGGACTTCCTTGGAATGTAGTGCGTATAAAGATTGTACAAATGTTAAGTGACACACTTAAAAATCTCTCTGACAGAGTCGTATTTGTCTTATGGGCACATGGCTTTGAGTTGACATCTATGAAGTATTTTGTGAAAATAGGACCTGAGCGCACCTGTTGTCTATGTGATAGACGTGCCACATGCTTTTCCACTGCTTCAGACACTTATGCCTGTTGGCATCATTCTATTGGATTTGATTACGTCTATAATCCGTTTATGATTGATGTTCAACAATGGGGTTTTACAGGTAACCTACAAAGCAACCATGATCTGTATTGTCAAGTCCATGGTAATGCACATGTAGCTAGTTGTGATGCAATCATGACTAGGTGTCTAGCTGTCCACGAGTGCTTTGTTAAGCGTGTTGACTGGACTATTGAATATCCTATAATTGGTGATGAACTGAAGATTAATGCGGCTTGTAGAAAGGTTCAACACATGGTTGTTAAAGCTGCATTATTAGCAGACAAATTCCCAGTTCTTCACGACATTGGTAACCCTAAAGCTATTAAGTGTGTACCTCAAGCTGATGTAGAATGGAAGTTCTATGATGCACAGCCTTGTAGTGACAAAGCTTATAAAATAGAAGAATTATTCTATTCTTATGCCACACATTCTGACAAATTCACAGATGGTGTATGCCTATTTTGGAATTGCAATGTCGATAGATATCCTGCTAATTCCATTGTTTGTAGATTTGACACTAGAGTGCTATCTAACCTTAACTTGCCTGGTTGTGATGGTGGCAGTTTGTATGTAAATAAACATGCATTCCACACACCAGCTTTTGATAAAAGTGCTTTTGTTAATTTAAAACAATTACCATTTTTCTATTACTCTGACAGTCCATGTGAGTCTCATGGAAAACAAGTAGTGTCAGATATAGATTATGTACCACTAAAGTCTGCTACGTGTATAACACGTTGCAATTTAGGTGGTGCTGTCTGTAGACATCATGCTAATGAGTACAGATTGTATCTCGATGCTTATAACATGATGATCTCAGCTGGCTTTAGCTTGTGGGTTTACAAACAATTTGATACTTATAACCTCTGGAACACTTTTACAAGACTTCAGAGTTTAGAAAATGTGGCTTTTAATGTTGTAAATAAGGGACACTTTGATGGACAACAGGGTGAAGTACCAGTTTCTATCATTAATAACACTGTTTACACAAAAGTTGATGGTGTTGATGTAGAATTGTTTGAAAATAAAACAACATTACCTGTTAATGTAGCATTTGAGCTTTGGGCTAAGCGCAACATTAAACCAGTACCAGAGGTGAAAATACTCAATAATTTGGGTGTGGACATTGCTGCTAATACTGTGATCTGGGACTACAAAAGAGATGCTCCAGCACATATATCTACTATTGGTGTTTGTTCTATGACTGACATAGCCAAGAAACCAACTGAAACGATTTGTGCACCACTCACTGTCTTTTTTGATGGTAGAGTTGATGGTCAAGTAGACTTATTTAGAAATGCCCGTAATGGTGTTCTTATTACAGAAGGTAGTGTTAAAGGTTTACAACCATCTGTAGGTCCCAAACAAGCTAGTCTTAATGGAGTCACATTAATTGGAGAAGCCGTAAAAACACAGTTCAATTATTATAAGAAAGTTGATGGTGTTGTCCAACAATTACCTGAAACTTACTTTACTCAGAGTAGAAATTTACAAGAATTTAAACCCAGGAGTCAAATGGAAATTGATTTCTTAGAATTAGCTATGGATGAATTCATTGAACGGTATAAATTAGAAGGCTATGCCTTCGAACATATCGTTTATGGAGATTTTAGTCATAGTCAGTTAGGTGGTTTACATCTACTGATTGGACTAGCTAAACGTTTTAAGGAATCACCTTTTGAATTAGAAGATTTTATTCCTATGGACAGTACAGTTAAAAACTATTTCATAACAGATGCGCAAACAGGTTCATCTAAGTGTGTGTGTTCTGTTATTGATTTATTACTTGATGATTTTGTTGAAATAATAAAATCCCAAGATTTATCTGTAGTTTCTAAGGTTGTCAAAGTGACTATTGACTATACAGAAATTTCATTTATGCTTTGGTGTAAAGATGGCCATGTAGAAACATTTTACCCAAAATTACAATCTAGTCAAGCGTGGCAACCGGGTGTTGCTATGCCTAATCTTTACAAAATGCAAAGAATGCTATTAGAAAAGTGTGACCTTCAAAATTATGGTGATAGTGCAACATTACCTAAAGGCATAATGATGAATGTCGCAAAATATACTCAACTGTGTCAATATTTAAACACATTAACATTAGCTGTACCCTATAATATGAGAGTTATACATTTTGGTGCTGGTTCTGATAAAGGAGTTGCACCAGGTACAGCTGTTTTAAGACAGTGGTTGCCTACGGGTACGCTGCTTGTCGATTCAGATCTTAATGACTTTGTCTCTGATGCAGATTCAACTTTGATTGGTGATTGTGCAACTGTACATACAGCTAATAAATGGGATCTCATTATTAGTGATATGTACGACCCTAAGACTAAAAATGTTACAAAAGAAAATGACTCTAAAGAGGGTTTTTTCACTTACATTTGTGGGTTTATACAACAAAAGCTAGCTCTTGGAGGTTCCGTGGCTATAAAGATAACAGAACATTCTTGGAATGCTGATCTTTATAAGCTCATGGGACACTTCGCATGGTGGACAGCCTTTGTTACTAATGTGAATGCGTCATCATCTGAAGCATTTTTAATTGGATGTAATTATCTTGGCAAACCACGCGAACAAATAGATGGTTATGTCATGCATGCAAATTACATATTTTGGAGGAATACAAATCCAATTCAGTTGTCTTCCTATTCTTTATTTGACATGAGTAAATTTCCCCTTAAATTAAGGGGTACTGCTGTTATGTCTTTAAAAGAAGGTCAAATCAATGATATGATTTTATCTCTTCTTAGTAAAGGTAGACTTATAATTAGAGAAAACAACAGAGTTGTTATTTCTAGTGATGTTCTTGTTAACAACTAAACGAACAATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAAACGAACTTATGGATTTGTTTATGAGAATCTTCACAATTGGAACTGTAACTTTGAAGCAAGGTGAAATCAAGGATGCTACTCCTTCAGATTTTGTTCGCGCTACTGCAACGATACCGATACAAGCCTCACTCCCTTTCGGATGGCTTATTGTTGGCGTTGCACTTCTTGCTGTTTTTCAGAGCGCTTCCAAAATCATAACCCTCAAAAAGAGATGGCAACTAGCACTCTCCAAGGGTGTTCACTTTGTTTGCAACTTGCTGTTGTTGTTTGTAACAGTTTACTCACACCTTTTGCTCGTTGCTGCTGGCCTTGAAGCCCCTTTTCTCTATCTTTATGCTTTAGTCTACTTCTTGCAGAGTATAAACTTTGTAAGAATAATAATGAGGCTTTGGCTTTGCTGGAAATGCCGTTCCAAAAACCCATTACTTTATGATGCCAACTATTTTCTTTGCTGGCATACTAATTGTTACGACTATTGTATACCTTACAATAGTGTAACTTCTTCAATTGTCATTACTTCAGGTGATGGCACAACAAGTCCTATTTCTGAACATGACTACCAGATTGGTGGTTATACTGAAAAATGGGAATCTGGAGTAAAAGACTGTGTTGTATTACACAGTTACTTCACTTCAGACTATTACCAGCTGTACTCAACTCAATTGAGTACAGACACTGGTGTTGAACATGTTACCTTCTTCATCTACAATAAAATTGTTGATGAGCCTGAAGAACATGTCCAAATTCACACAATCGACGGTTCATCCGGAGTTGTTAATCCAGTAATGGAACCAATTTATGATGAACCGACGACGACTACTAGCGTGCCTTTGTAAGCACAAGCTGATGAGTACGAACTTATGTACTCATTCGTTTCGGAAGAGACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTTACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTCTTGTAAAACCTTCTTTTTACGTTTACTCTCGTGTTAAAAATCTGAATTCTTCTAGAGTTCCTGATCTTCTGGTCTAAACGAACTAAATATTATATTAGTTTTTCTGTTTGGAACTTTAATTTTAGCCATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAAGTGACAACAGATGTTTCATCTCGTTGACTTTCAGGTTACTATAGCAGAGATATTACTAATTATTATGAGGACTTTTAAAGTTTCCATTTGGAATCTTGATTACATCATAAACCTCATAATTAAAAATTTATCTAAGTCACTAACTGAGAATAAATATTCTCAATTAGATGAAGAGCAACCAATGGAGATTGATTAAACGAACATGAAAATTATTCTTTTCTTGGCACTGATAACACTCGCTACTTGTGAGCTTTATCACTACCAAGAGTGTGTTAGAGGTACAACAGTACTTTTAAAAGAACCTTGCTCTTCTGGAACATACGAGGGCAATTCACCATTTCATCCTCTAGCTGATAACAAATTTGCACTGACTTGCTTTAGCACTCAATTTGCTTTTGCTTGTCCTGACGGCGTAAAACACGTCTATCAGTTACGTGCCAGATCAGTTTCACCTAAACTGTTCATCAGACAAGAGGAAGTTCAAGAACTTTACTCTCCAATTTTTCTTATTGTTGCGGCAATAGTGTTTATAACACTTTGCTTCACACTCAAAAGAAAGACAGAATGATTGAACTTTCATTAATTGACTTCTATTTGTGCTTTTTAGCCTTTCTGCTATTCCTTGTTTTAATTATGCTTATTATCTTTTGGTTCTCACTTGAACTGCAAGATCATAATGAAACTTGTCACGCCTAAACGAACATGAAATTTCTTGTTTTCTTAGGAATCATCACAACTGTAGCTGCATTTCACCAAGAATGTAGTTTACAGTCATGTACTCAACATCAACCATATGTAGTTGATGACCCGTGTCCTATTCACTTCTATTCTAAATGGTATATTAGAGTAGGAGCTAGAAAATCAGCACCTTTAATTGAATTGTGCGTGGATGAGGCTGGTTCTAAATCACCCATTCAGTACATCGATATCGGTAATTATACAGTTTCCTGTTTACCTTTTACAATTAATTGCCAGGAACCTAAATTGGGTAGTCTTGTAGTGCGTTGTTCGTTCTATGAAGACTTTTTAGAGTATCATGACGTTCGTGTTGTTTTAGATTTCATCTAAACGAACAAACTAAAATGTCTGATAATGGACCCCAAAATCAGCGAAATGCACCCCGCATTACGTTTGGTGGACCCTCAGATTCAACTGGCAGTAACCAGAATGGAGAACGCAGTGGGGCGCGATCAAAACAACGTCGGCCCCAAGGTTTACCCAATAATACTGCGTCTTGGTTCACCGCTCTCACTCAACATGGCAAGGAAGACCTTAAATTCCCTCGAGGACAAGGCGTTCCAATTAACACCAATAGCAGTCCAGATGACCAAATTGGCTACTACCGAAGAGCTACCAGACGAATTCGTGGTGGTGACGGTAAAATGAAAGATCTCAGTCCAAGATGGTATTTCTACTACCTAGGAACTGGGCCAGAAGCTGGACTTCCCTATGGTGCTAACAAAGACGGCATCATATGGGTTGCAACTGAGGGAGCCTTGAATACACCAAAAGATCACATTGGCACCCGCAATCCTGCTAACAATGCTGCAATCGTGCTACAACTTCCTCAAGGAACAACATTGCCAAAAGGCTTCTACGCAGAAGGGAGCAGAGGCGGCAGTCAAGCCTCTTCTCGTTCCTCATCACGTAGTCGCAACAGTTCAAGAAATTCAACTCCAGGCAGCAGTAGGGGAACTTCTCCTGCTAGAATGGCTGGCAATGGCGGTGATGCTGCTCTTGCTTTGCTGCTGCTTGACAGATTGAACCAGCTTGAGAGCAAAATGTCTGGTAAAGGCCAACAACAACAAGGCCAAACTGTCACTAAGAAATCTGCTGCTGAGGCTTCTAAGAAGCCTCGGCAAAAACGTACTGCCACTAAAGCATACAATGTAACACAAGCTTTCGGCAGACGTGGTCCAGAACAAACCCAAGGAAATTTTGGGGACCAGGAACTAATCAGACAAGGAACTGATTACAAACATTGGCCGCAAATTGCACAATTTGCCCCCAGCGCTTCAGCGTTCTTCGGAATGTCGCGCATTGGCATGGAAGTCACACCTTCGGGAACGTGGTTGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCATTTTGCTGAATAAGCATATTGACGCATACAAAACATTCCCACCAACAGAGCCTAAAAAGGACAAAAAGAAGAAGGCTGATGAAACTCAAGCCTTACCGCAGAGACAGAAGAAACAGCAAACTGTGACTCTTCTTCCTGCTGCAGATTTGGATGATTTCTCCAAACAATTGCAACAATCCATGAGCAGTGCTGACTCAACTCAGGCCTAAACTCATGCAGACCACACAAGGCAGATGGGCTATATAAACGTTTTCGCTTTTCCGTTTACGATATATAGTCTACTCTTGTGCAGAATGAATTCTCGTAACTACATAGCACAAGTAGATGTAGTTAACTTTAATCTCACATAGCAATCTTTAATCAGTGTGTAACATTAGGGAGGACTTGAAAGAGCCACCACATTTTCACCGAGGCCACGCGGAGTACGATCGAGTGTACAGTGAACAATGCTAGGGAGAGCTGCCTATATGGAAGAGCCCTAATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTAGGAGAATGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA"}}